Leiomyosarcoma
Zapobieganie i profilaktyka
Leiomyosarcoma to agresywny mięsak tkanek miękkich wywodzący się z mięśni gładkich, charakteryzujący się szybkim wzrostem i wysokim ryzykiem przerzutów. Profilaktyka pierwotna jest ograniczona ze względu na brak jednoznacznych metod zapobiegania, a większość przypadków rozwija się bez wyraźnych czynników ryzyka. Zidentyfikowano jednak czynniki zwiększające ryzyko, takie jak ekspozycja na promieniowanie jonizujące (w tym diagnostyczne RTG i TK), kontakt z dioksynami, herbicydami, PCB, stosowanie tamoksyfenu (zwiększające ryzyko leiomyosarcoma macicy), predyspozycje genetyczne (neurofibromatoza, zespół Li-Fraumeni, siatkówczak) oraz palenie tytoniu. Wczesne rozpoznanie i leczenie pozostają kluczowe dla poprawy przeżywalności, a działania profilaktyczne obejmują ograniczenie ekspozycji na czynniki ryzyka, zdrowy styl życia, regularną aktywność fizyczną, zbilansowaną dietę oraz utrzymanie prawidłowej masy ciała. Osoby z obciążeniem genetycznym powinny rozważyć konsultacje genetyczne i regularną kontrolę lekarską.
Wprowadzenie do tematyki Leiomyosarcoma
Leiomyosarcoma to rzadki, agresywny nowotwór wywodzący się z tkanek mięśni gładkich. Jest to jeden z typów mięsaków tkanek miękkich, charakteryzujący się szybkim wzrostem i skłonnością do przerzutów. Niestety, w przypadku tego schorzenia medycyna nie dysponuje obecnie pewnymi i skutecznymi metodami profilaktyki pierwotnej, co potwierdzają liczne źródła naukowe.12
Podobnie jak większość mięsaków, leiomyosarcoma rozwija się najczęściej u osób bez zidentyfikowanych czynników ryzyka, co dodatkowo utrudnia opracowanie skutecznych strategii zapobiegawczych. Warto jednak zaznaczyć, że wczesne rozpoznanie i leczenie mają kluczowe znaczenie dla poprawy wskaźników przeżywalności pacjentów.34
Czynniki ryzyka Leiomyosarcoma
Chociaż nie ma pewnych metod zapobiegania leiomyosarcoma, zidentyfikowano czynniki ryzyka, których ograniczenie może zmniejszyć prawdopodobieństwo wystąpienia tej choroby:56
- Ekspozycja na promieniowanie jonizujące – w tym promieniowanie stosowane podczas leczenia onkologicznego, diagnostyka z użyciem promieniowania rentgenowskiego lub tomografii komputerowej7
- Kontakt z określonymi substancjami chemicznymi – szczególnie związkami takimi jak dioksyny, herbicydy i polichlorowane bifenyle (PCB)89
- Przyjmowanie tamoksyfenu – lek stosowany w leczeniu raka piersi może zwiększać ryzyko rozwoju leiomyosarcoma macicy1011
- Predyspozycje genetyczne – zespoły genetyczne takie jak neurofibromatoza, zespół Li-Fraumeni i siatkówczak mogą zwiększać ryzyko zachorowania12
- Palenie tytoniu – identyfikowane jako istotny czynnik ryzyka dla mięsaków13
Strategie profilaktyczne Leiomyosarcoma
Mimo że obecnie nie istnieją metody całkowicie zapobiegające rozwojowi leiomyosarcoma, można wdrożyć pewne strategie minimalizujące ryzyko zachorowania lub poprawiające rokowanie poprzez wczesne wykrycie:1415
Modyfikacja czynników ryzyka
- Ograniczenie ekspozycji na promieniowanie – minimalizacja niezbędnych badań diagnostycznych wykorzystujących promieniowanie jonizujące i stosowanie odpowiednich środków ochronnych podczas koniecznej ekspozycji1617
- Unikanie ekspozycji na szkodliwe substancje chemiczne – stosowanie środków ochrony osobistej w miejscu pracy, przestrzeganie wytycznych bezpieczeństwa i ograniczanie kontaktu z potencjalnie szkodliwymi substancjami1819
- Zaprzestanie palenia tytoniu – rezygnacja z palenia może znacząco zmniejszyć ryzyko wystąpienia mięsaka20
- Ochrona przed promieniowaniem słonecznym – ograniczenie nadmiernej ekspozycji na promieniowanie UV poprzez stosowanie kremów z filtrem i unikanie przebywania na słońcu w godzinach największego nasłonecznienia21
Zdrowy styl życia
Prowadzenie zdrowego stylu życia może wzmocnić układ odpornościowy i poprawić ogólną kondycję organizmu, co potencjalnie może zmniejszyć ryzyko rozwoju wielu nowotworów, w tym leiomyosarcoma:22
- Regularna aktywność fizyczna – może zapobiegać rozwojowi nowotworów poprzez wzmacnianie układu odpornościowego i regulację procesów metabolicznych23
- Zbilansowana dieta – bogata w warzywa, owoce i pełnoziarniste produkty wspiera prawidłowe funkcjonowanie układu odpornościowego24
- Utrzymywanie prawidłowej masy ciała – otyłość jest czynnikiem ryzyka wielu nowotworów, dlatego utrzymywanie prawidłowej masy ciała może zmniejszyć ryzyko zachorowania25
Poradnictwo genetyczne
Osoby z rodzinnym obciążeniem nowotworami lub zespołami genetycznymi zwiększającymi ryzyko leiomyosarcoma powinny rozważyć konsultację genetyczną:2627
- Badania genetyczne – mogą pomóc w identyfikacji osób z podwyższonym ryzykiem zachorowania, choć należy pamiętać, że nie istnieje wiele testów genetycznych, które dokładnie przewidują ryzyko mięsaków28
- Konsultacje z lekarzem – osoby z rodzinnym wywiadem neurofibromatozy, zespołu Li-Fraumeni, siatkówczaka lub mięsaka tkanek miękkich powinny regularnie konsultować się z lekarzem2930
Wczesne wykrywanie Leiomyosarcoma
Chociaż nie istnieją specyficzne badania przesiewowe dla leiomyosarcoma, wczesne wykrycie choroby ma kluczowe znaczenie dla poprawy rokowania:3132
Samobadanie i czujność onkologiczna
Istotnym elementem profilaktyki wtórnej jest samoobserwacja i zgłaszanie wszystkich niepokojących objawów lekarzowi:3334
- Regularne samobadanie – szczególna uwaga na wszelkie guzki, zgrubienia, bóle lub obrzęki35
- Natychmiastowa konsultacja medyczna – w przypadku wykrycia jakichkolwiek niepokojących zmian, zwłaszcza guzków, które powiększają się lub powodują ból3637
- Regularny kontakt z lekarzem – zwłaszcza w przypadku osób z podwyższonym ryzykiem rozwoju mięsaków38
Należy podkreślić, że choć większość wyczuwalnych guzków nie jest mięsakami, to każdy niepokojący objaw powinien zostać skonsultowany z lekarzem. Pacjenci nie powinni obawiać się prosić o dodatkowe badania, jeśli mają wątpliwości co do diagnozy.39
Monitorowanie w grupach wysokiego ryzyka
Osoby z grupy podwyższonego ryzyka powinny być poddawane regularnym kontrolom lekarskim:4041
- Pacjenci po radioterapii miednicy – powinni być regularnie badani w kierunku potencjalnych zmian nowotworowych42
- Osoby przyjmujące tamoksyfen – wymagają regularnych kontroli ginekologicznych ze względu na zwiększone ryzyko leiomyosarcoma macicy4344
- Pacjenci z zespołami genetycznymi – powinni pozostawać pod stałą opieką specjalistów i być regularnie monitorowani45
Profilaktyka nawrotów i przerzutów
W przypadku pacjentów z rozpoznanym leiomyosarcoma istotne znaczenie ma profilaktyka wtórna, mająca na celu zapobieganie nawrotom lokalnym i przerzutom:4647
Leczenie uzupełniające
Po leczeniu chirurgicznym może być zalecane leczenie uzupełniające w celu zmniejszenia ryzyka nawrotu:4849
- Radioterapia adjuwantowa – może znacząco zmniejszyć ryzyko wznowy miejscowej, nawet z 30-37% do 0%, szczególnie w przypadku guzów wysokiego stopnia złośliwości lub w przypadku nieradykalnego wycięcia guza5051
- Chemioterapia systemowa – może być stosowana w celu zmniejszenia ryzyka przerzutów odległych i poprawy przeżywalności52
Limfadenektomia profilaktyczna
W przypadku leiomyosarcoma zlokalizowanego w powrózku nasiennym, profilaktyczna limfadenektomia zaotrzewnowa nie jest konieczna, chyba że występują dowody na zajęcie węzłów chłonnych lub histologia guza wskazuje na skłonność do przerzutów do węzłów chłonnych.53
Wyzwania w profilaktyce Leiomyosarcoma podczas pandemii COVID-19
Pandemia COVID-19 stworzyła dodatkowe wyzwania w zakresie diagnostyki i leczenia pacjentów z leiomyosarcoma, co może negatywnie wpływać na wczesne wykrywanie tego nowotworu:5455
- Ograniczony dostęp do opieki podstawowej – niechęć pacjentów do wizyt lekarskich oraz ograniczona dostępność świadczeń medycznych niezwiązanych z COVID-1956
- Opóźnienia w diagnostyce – pacjenci często zgłaszają się później, gdy choroba jest już w zaawansowanym stadium57
- Modyfikacje w systemie opieki zdrowotnej – przesunięcie zasobów na walkę z pandemią COVID-19 kosztem innych obszarów medycyny58
- Skala pilności zabiegów chirurgicznych – wprowadzona przez Amerykańskie Kolegium Chirurgów w celu określenia, którzy pacjenci powinni być operowani w pierwszej kolejności59
Telemedycyna jako narzędzie profilaktyki
W czasie pandemii telemedycyna stała się cennym narzędziem umożliwiającym utrzymanie ciągłości opieki nad pacjentami:60
- Minimalizacja ryzyka ekspozycji – zarówno dla pacjentów, jak i personelu medycznego61
- Zapewnienie terminowej opieki – możliwość konsultacji mimo ograniczeń związanych z pandemią62
- Bilans ryzyka – konieczność wyważenia ryzyka związanego z opóźnieniem diagnostyki i leczenia nowotworu oraz ryzyka zakażenia COVID-1963
Podsumowanie kliniczne
Leiomyosarcoma pozostaje trudnym wyzwaniem dla współczesnej medycyny, szczególnie w zakresie profilaktyki. Mimo że nie ma ustalonych metod zapobiegania rozwojowi tego nowotworu, kluczowe znaczenie ma modyfikacja możliwych czynników ryzyka oraz wczesne wykrywanie choroby.646566
Lekarze powinni informować pacjentów o ograniczonych możliwościach profilaktyki pierwotnej leiomyosarcoma, jednocześnie podkreślając znaczenie szybkiej diagnostyki i leczenia w przypadku wystąpienia niepokojących objawów. Szczególnie istotna jest regularna kontrola w grupach podwyższonego ryzyka, takich jak osoby po radioterapii miednicy czy przyjmujące tamoksyfen.676869
Dla pacjentów po leczeniu leiomyosarcoma, radioterapia uzupełniająca może znacząco zmniejszyć ryzyko wznowy miejscowej, zwłaszcza w przypadku guzów wysokiego stopnia złośliwości lub nieradykalnej resekcji.7071
Wyzwania związane z pandemią COVID-19 podkreślają potrzebę elastycznego podejścia do diagnostyki i leczenia leiomyosarcoma, z wykorzystaniem telemedycyny jako narzędzia pozwalającego na zachowanie ciągłości opieki przy jednoczesnej minimalizacji ryzyka zakażenia.7273
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Materiały źródłowe
- #1 Leiomyosarcoma – Symptoms and causes – Mayo Clinichttps://www.mayoclinic.org/diseases-conditions/leiomyosarcoma/symptoms-causes/syc-20577215
Healthcare professionals haven’t found a way to prevent leiomyosarcoma.
- #2https://winshipcancer.emory.edu/cancer-types-and-treatments/sarcoma/prevention.php
Prevention is not yet possible for sarcomas, but Winships team of experts continues to work on sarcoma prevention to give you the best outcomes possible. […] The vast majority of sarcomas are sporadic, meaning they occur at random with no known way to prevent them. […] While sarcomas cannot be prevented, there are ways to effectively diagnose and treat them. […] Sarcoma prevention does not yet exist. According to experts, there are no lifestyle-related or environmental causes of sarcoma, which means that there is no determined way to prevent these tumors from forming.
- #3 Scalp Leiomyosarcoma: Diagnosis and Treatment During a Global Pandemic With COVID-19 | Hassan | World Journal of Oncologyhttps://www.wjon.org/index.php/wjon/article/view/1393/1069
Leiomyosarcoma is an aggressive, uncommon sarcoma effecting smooth muscle tissue. Prompt tissue diagnosis and staging workup are keys to preventing distant metastasis. […] Although diagnosis and treatment for rare cancers have already been difficult, it has become increasingly challenging due to the coronavirus disease of 2019 (COVID-19) pandemic. […] The purpose of this report is to discuss both diagnosis and management of leiomyosarcoma in the scalp to aid physicians navigating cancer care during the pandemic. […] Prompt diagnosis and treatment is crucial to improve overall survival from this challenging disease. […] Cure of leiomyosarcoma depends on early diagnosis and prompt management; if the sarcoma is diagnosed before locally advanced state or distant metastasis, complete tumor excision has potential to be curative.
- #4 Soft Tissue Sarcoma Causes, Risk Factors, and Prevention | American Cancer Societyhttps://www.cancer.org/cancer/types/soft-tissue-sarcoma/causes-risks-prevention.html
The only way to prevent some soft tissue sarcomas is to avoid exposure to risk factors whenever possible. […] Still, most sarcomas develop in people with no known risk factors. […] At this time, there’s no known way to prevent this cancer. […] And for people getting radiation therapy, there’s usually little choice.
- #5 Understanding Your Risks of Sarcomahttps://www.stjohns.health/blog/2022/june/understanding-your-risks-of-sarcoma/
Currently, most sarcomas develop in people with no known risk factors which makes prevention vital. There is no sure way to prevent sarcoma, but there are some steps you can take to reduce your risk. […] Quit smoking. Smoking is the most important risk factor for sarcoma, and quitting smoking can greatly reduce your risk. […] Avoid exposure to certain chemicals. Some chemicals, such as dioxins and polychlorinated biphenyls (PCBs), have been linked to an increased risk of sarcoma. […] Limit your exposure to radiation. Exposure to radiation, such as from X-rays, cancer treatment, or CT scans, can increase your risk of sarcoma. If you need an imaging test, talk to your doctor about the risks and benefits. […] Know your family history. If sarcoma runs in your family, you may be at an increased risk. Talk to your doctor about your family history and what you can do to reduce your risk.
- #6 Soft Tissue Sarcoma Risk Factors and Prevention Measureshttps://www.hcgoncology.com/types-of-cancers/soft-tissue-sarcoma-prevention/
Several factors enhance the risk of soft tissue sarcoma. Clinicians must identify those risk factors and provide appropriate preventive measures to lower the risk of developing soft tissue sarcoma. […] Although it is impossible to prevent soft tissue sarcoma, certain soft tissue sarcoma prevention measures lower its risk. Soft tissue sarcoma prevention strategies include minimizing modifiable risk factors and adhering to a healthy lifestyle. Some soft tissue sarcoma prevention measures are: […] Minimizing exposure to ionizing radiation from medical treatments or occupational sources may lower the risk of radiation-induced soft tissue sarcomas. […] Reducing exposure to harmful chemicals in the workplace or the environment, following safety guidelines, and using protective measures while working with harmful chemicals can reduce the risk of soft tissue sarcoma.
- #7 Understanding Your Risks of Sarcomahttps://www.stjohns.health/blog/2022/june/understanding-your-risks-of-sarcoma/
Currently, most sarcomas develop in people with no known risk factors which makes prevention vital. There is no sure way to prevent sarcoma, but there are some steps you can take to reduce your risk. […] Quit smoking. Smoking is the most important risk factor for sarcoma, and quitting smoking can greatly reduce your risk. […] Avoid exposure to certain chemicals. Some chemicals, such as dioxins and polychlorinated biphenyls (PCBs), have been linked to an increased risk of sarcoma. […] Limit your exposure to radiation. Exposure to radiation, such as from X-rays, cancer treatment, or CT scans, can increase your risk of sarcoma. If you need an imaging test, talk to your doctor about the risks and benefits. […] Know your family history. If sarcoma runs in your family, you may be at an increased risk. Talk to your doctor about your family history and what you can do to reduce your risk.
- #8 Soft Tissue Sarcoma Prevention | Stanford Health Carehttps://stanfordhealthcare.org/medical-conditions/cancer/soft-tissue-sarcoma/prevention.html
Because most people who get soft tissue sarcoma do not have any risk factors, doctors have little advice on how you can prevent this very rare form of cancer. […] Remember, you can have all the risk factors and not get soft tissue sarcoma. Or you can have none of them and get this illness. Talk to your doctor if you are concerned about your risk. […] When possible, you should avoid these risk factors. […] Avoid exposure to radiation. (This may not be possible for people who need radiation to treat cancer.) […] Avoid exposure to certain chemicals, especially herbicides and dioxin. […] If you or anyone in your family has had neurofibromatosis, Li-Fraumeni syndrome, retinoblastoma, or soft tissue sarcoma, you may have a slightly elevated risk of this type of cancer. Ask your doctor if you should be tested for inherited genes that might increase your risk of soft tissue sarcoma. It is important to know that there are not a lot of genetic tests to accurately predict your risk for sarcomas.
- #9 Understanding Your Risks of Sarcomahttps://www.stjohns.health/blog/2022/june/understanding-your-risks-of-sarcoma/
Currently, most sarcomas develop in people with no known risk factors which makes prevention vital. There is no sure way to prevent sarcoma, but there are some steps you can take to reduce your risk. […] Quit smoking. Smoking is the most important risk factor for sarcoma, and quitting smoking can greatly reduce your risk. […] Avoid exposure to certain chemicals. Some chemicals, such as dioxins and polychlorinated biphenyls (PCBs), have been linked to an increased risk of sarcoma. […] Limit your exposure to radiation. Exposure to radiation, such as from X-rays, cancer treatment, or CT scans, can increase your risk of sarcoma. If you need an imaging test, talk to your doctor about the risks and benefits. […] Know your family history. If sarcoma runs in your family, you may be at an increased risk. Talk to your doctor about your family history and what you can do to reduce your risk.
- #10 Uterine Sarcoma: Symptoms, Diagnosis, Treatment & Preventionhttps://my.clevelandclinic.org/health/diseases/16408-uterine-sarcoma
We don’t know how to prevent uterine sarcoma yet, but we know about certain risk factors, such as receiving pelvic area radiation and taking tamoxifen for breast cancer. Treatment benefits often outweigh the risks associated with developing uterine sarcoma, especially since it’s so rare. […] Speak to your provider about the risks associated with any cancer treatment, and weigh the pros and cons of the treatment options available.
- #11 Uterine sarcoma: MedlinePlus Medical EncyclopediaLockhttps://medlineplus.gov/ency/article/007655.htm
There is no known way to prevent uterine sarcoma. If you have had radiation therapy in your pelvic area or have taken tamoxifen for breast cancer, ask your provider how often you should be checked for possible problems.
- #12 Soft Tissue Sarcoma Prevention | Stanford Health Carehttps://stanfordhealthcare.org/medical-conditions/cancer/soft-tissue-sarcoma/prevention.html
Because most people who get soft tissue sarcoma do not have any risk factors, doctors have little advice on how you can prevent this very rare form of cancer. […] Remember, you can have all the risk factors and not get soft tissue sarcoma. Or you can have none of them and get this illness. Talk to your doctor if you are concerned about your risk. […] When possible, you should avoid these risk factors. […] Avoid exposure to radiation. (This may not be possible for people who need radiation to treat cancer.) […] Avoid exposure to certain chemicals, especially herbicides and dioxin. […] If you or anyone in your family has had neurofibromatosis, Li-Fraumeni syndrome, retinoblastoma, or soft tissue sarcoma, you may have a slightly elevated risk of this type of cancer. Ask your doctor if you should be tested for inherited genes that might increase your risk of soft tissue sarcoma. It is important to know that there are not a lot of genetic tests to accurately predict your risk for sarcomas.
- #13 Understanding Your Risks of Sarcomahttps://www.stjohns.health/blog/2022/june/understanding-your-risks-of-sarcoma/
Currently, most sarcomas develop in people with no known risk factors which makes prevention vital. There is no sure way to prevent sarcoma, but there are some steps you can take to reduce your risk. […] Quit smoking. Smoking is the most important risk factor for sarcoma, and quitting smoking can greatly reduce your risk. […] Avoid exposure to certain chemicals. Some chemicals, such as dioxins and polychlorinated biphenyls (PCBs), have been linked to an increased risk of sarcoma. […] Limit your exposure to radiation. Exposure to radiation, such as from X-rays, cancer treatment, or CT scans, can increase your risk of sarcoma. If you need an imaging test, talk to your doctor about the risks and benefits. […] Know your family history. If sarcoma runs in your family, you may be at an increased risk. Talk to your doctor about your family history and what you can do to reduce your risk.
- #14 Soft Tissue Sarcoma Risk Factors and Prevention Measureshttps://www.hcgoncology.com/types-of-cancers/soft-tissue-sarcoma-prevention/
Several factors enhance the risk of soft tissue sarcoma. Clinicians must identify those risk factors and provide appropriate preventive measures to lower the risk of developing soft tissue sarcoma. […] Although it is impossible to prevent soft tissue sarcoma, certain soft tissue sarcoma prevention measures lower its risk. Soft tissue sarcoma prevention strategies include minimizing modifiable risk factors and adhering to a healthy lifestyle. Some soft tissue sarcoma prevention measures are: […] Minimizing exposure to ionizing radiation from medical treatments or occupational sources may lower the risk of radiation-induced soft tissue sarcomas. […] Reducing exposure to harmful chemicals in the workplace or the environment, following safety guidelines, and using protective measures while working with harmful chemicals can reduce the risk of soft tissue sarcoma.
- #15 Understanding Your Risks of Sarcomahttps://www.stjohns.health/blog/2022/june/understanding-your-risks-of-sarcoma/
Currently, most sarcomas develop in people with no known risk factors which makes prevention vital. There is no sure way to prevent sarcoma, but there are some steps you can take to reduce your risk. […] Quit smoking. Smoking is the most important risk factor for sarcoma, and quitting smoking can greatly reduce your risk. […] Avoid exposure to certain chemicals. Some chemicals, such as dioxins and polychlorinated biphenyls (PCBs), have been linked to an increased risk of sarcoma. […] Limit your exposure to radiation. Exposure to radiation, such as from X-rays, cancer treatment, or CT scans, can increase your risk of sarcoma. If you need an imaging test, talk to your doctor about the risks and benefits. […] Know your family history. If sarcoma runs in your family, you may be at an increased risk. Talk to your doctor about your family history and what you can do to reduce your risk.
- #16 Soft Tissue Sarcoma Risk Factors and Prevention Measureshttps://www.hcgoncology.com/types-of-cancers/soft-tissue-sarcoma-prevention/
Several factors enhance the risk of soft tissue sarcoma. Clinicians must identify those risk factors and provide appropriate preventive measures to lower the risk of developing soft tissue sarcoma. […] Although it is impossible to prevent soft tissue sarcoma, certain soft tissue sarcoma prevention measures lower its risk. Soft tissue sarcoma prevention strategies include minimizing modifiable risk factors and adhering to a healthy lifestyle. Some soft tissue sarcoma prevention measures are: […] Minimizing exposure to ionizing radiation from medical treatments or occupational sources may lower the risk of radiation-induced soft tissue sarcomas. […] Reducing exposure to harmful chemicals in the workplace or the environment, following safety guidelines, and using protective measures while working with harmful chemicals can reduce the risk of soft tissue sarcoma.
- #17 Soft Tissue Sarcoma Prevention | Stanford Health Carehttps://stanfordhealthcare.org/medical-conditions/cancer/soft-tissue-sarcoma/prevention.html
Because most people who get soft tissue sarcoma do not have any risk factors, doctors have little advice on how you can prevent this very rare form of cancer. […] Remember, you can have all the risk factors and not get soft tissue sarcoma. Or you can have none of them and get this illness. Talk to your doctor if you are concerned about your risk. […] When possible, you should avoid these risk factors. […] Avoid exposure to radiation. (This may not be possible for people who need radiation to treat cancer.) […] Avoid exposure to certain chemicals, especially herbicides and dioxin. […] If you or anyone in your family has had neurofibromatosis, Li-Fraumeni syndrome, retinoblastoma, or soft tissue sarcoma, you may have a slightly elevated risk of this type of cancer. Ask your doctor if you should be tested for inherited genes that might increase your risk of soft tissue sarcoma. It is important to know that there are not a lot of genetic tests to accurately predict your risk for sarcomas.
- #18 Soft Tissue Sarcoma Risk Factors and Prevention Measureshttps://www.hcgoncology.com/types-of-cancers/soft-tissue-sarcoma-prevention/
Several factors enhance the risk of soft tissue sarcoma. Clinicians must identify those risk factors and provide appropriate preventive measures to lower the risk of developing soft tissue sarcoma. […] Although it is impossible to prevent soft tissue sarcoma, certain soft tissue sarcoma prevention measures lower its risk. Soft tissue sarcoma prevention strategies include minimizing modifiable risk factors and adhering to a healthy lifestyle. Some soft tissue sarcoma prevention measures are: […] Minimizing exposure to ionizing radiation from medical treatments or occupational sources may lower the risk of radiation-induced soft tissue sarcomas. […] Reducing exposure to harmful chemicals in the workplace or the environment, following safety guidelines, and using protective measures while working with harmful chemicals can reduce the risk of soft tissue sarcoma.
- #19 Soft Tissue Sarcoma Prevention | Stanford Health Carehttps://stanfordhealthcare.org/medical-conditions/cancer/soft-tissue-sarcoma/prevention.html
Because most people who get soft tissue sarcoma do not have any risk factors, doctors have little advice on how you can prevent this very rare form of cancer. […] Remember, you can have all the risk factors and not get soft tissue sarcoma. Or you can have none of them and get this illness. Talk to your doctor if you are concerned about your risk. […] When possible, you should avoid these risk factors. […] Avoid exposure to radiation. (This may not be possible for people who need radiation to treat cancer.) […] Avoid exposure to certain chemicals, especially herbicides and dioxin. […] If you or anyone in your family has had neurofibromatosis, Li-Fraumeni syndrome, retinoblastoma, or soft tissue sarcoma, you may have a slightly elevated risk of this type of cancer. Ask your doctor if you should be tested for inherited genes that might increase your risk of soft tissue sarcoma. It is important to know that there are not a lot of genetic tests to accurately predict your risk for sarcomas.
- #20 Understanding Your Risks of Sarcomahttps://www.stjohns.health/blog/2022/june/understanding-your-risks-of-sarcoma/
Currently, most sarcomas develop in people with no known risk factors which makes prevention vital. There is no sure way to prevent sarcoma, but there are some steps you can take to reduce your risk. […] Quit smoking. Smoking is the most important risk factor for sarcoma, and quitting smoking can greatly reduce your risk. […] Avoid exposure to certain chemicals. Some chemicals, such as dioxins and polychlorinated biphenyls (PCBs), have been linked to an increased risk of sarcoma. […] Limit your exposure to radiation. Exposure to radiation, such as from X-rays, cancer treatment, or CT scans, can increase your risk of sarcoma. If you need an imaging test, talk to your doctor about the risks and benefits. […] Know your family history. If sarcoma runs in your family, you may be at an increased risk. Talk to your doctor about your family history and what you can do to reduce your risk.
- #21 Soft Tissue Sarcoma Risk Factors and Prevention Measureshttps://www.hcgoncology.com/types-of-cancers/soft-tissue-sarcoma-prevention/
Individuals with a family history of soft tissue sarcoma or those who are suffering from genetic syndromes that enhance the risk of soft tissue sarcoma should be provided genetic counseling. Information should be obtained about their risk of developing soft tissue sarcoma. […] Like other cancers, a healthy lifestyle reduces the risk of soft tissue sarcoma. It helps improve the immune system and enhances the body’s ability to fight against abnormal cells. Engaging in regular physical activity may prevent cancer. A well-balanced diet comprising vegetables, fruits, and whole grains supports a healthy immune system. […] Excessive exposure to solar radiation should be avoided to lower the risk of soft tissue sarcoma. It includes going out in the sun only when necessary and using sunscreen lotions.
- #22 Soft Tissue Sarcoma Risk Factors and Prevention Measureshttps://www.hcgoncology.com/types-of-cancers/soft-tissue-sarcoma-prevention/
Individuals with a family history of soft tissue sarcoma or those who are suffering from genetic syndromes that enhance the risk of soft tissue sarcoma should be provided genetic counseling. Information should be obtained about their risk of developing soft tissue sarcoma. […] Like other cancers, a healthy lifestyle reduces the risk of soft tissue sarcoma. It helps improve the immune system and enhances the body’s ability to fight against abnormal cells. Engaging in regular physical activity may prevent cancer. A well-balanced diet comprising vegetables, fruits, and whole grains supports a healthy immune system. […] Excessive exposure to solar radiation should be avoided to lower the risk of soft tissue sarcoma. It includes going out in the sun only when necessary and using sunscreen lotions.
- #23 Soft Tissue Sarcoma Risk Factors and Prevention Measureshttps://www.hcgoncology.com/types-of-cancers/soft-tissue-sarcoma-prevention/
Individuals with a family history of soft tissue sarcoma or those who are suffering from genetic syndromes that enhance the risk of soft tissue sarcoma should be provided genetic counseling. Information should be obtained about their risk of developing soft tissue sarcoma. […] Like other cancers, a healthy lifestyle reduces the risk of soft tissue sarcoma. It helps improve the immune system and enhances the body’s ability to fight against abnormal cells. Engaging in regular physical activity may prevent cancer. A well-balanced diet comprising vegetables, fruits, and whole grains supports a healthy immune system. […] Excessive exposure to solar radiation should be avoided to lower the risk of soft tissue sarcoma. It includes going out in the sun only when necessary and using sunscreen lotions.
- #24 Soft Tissue Sarcoma Risk Factors and Prevention Measureshttps://www.hcgoncology.com/types-of-cancers/soft-tissue-sarcoma-prevention/
Individuals with a family history of soft tissue sarcoma or those who are suffering from genetic syndromes that enhance the risk of soft tissue sarcoma should be provided genetic counseling. Information should be obtained about their risk of developing soft tissue sarcoma. […] Like other cancers, a healthy lifestyle reduces the risk of soft tissue sarcoma. It helps improve the immune system and enhances the body’s ability to fight against abnormal cells. Engaging in regular physical activity may prevent cancer. A well-balanced diet comprising vegetables, fruits, and whole grains supports a healthy immune system. […] Excessive exposure to solar radiation should be avoided to lower the risk of soft tissue sarcoma. It includes going out in the sun only when necessary and using sunscreen lotions.
- #25 Soft Tissue Sarcoma Risk Factors and Prevention Measureshttps://www.hcgoncology.com/types-of-cancers/soft-tissue-sarcoma-prevention/
Individuals with a family history of soft tissue sarcoma or those who are suffering from genetic syndromes that enhance the risk of soft tissue sarcoma should be provided genetic counseling. Information should be obtained about their risk of developing soft tissue sarcoma. […] Like other cancers, a healthy lifestyle reduces the risk of soft tissue sarcoma. It helps improve the immune system and enhances the body’s ability to fight against abnormal cells. Engaging in regular physical activity may prevent cancer. A well-balanced diet comprising vegetables, fruits, and whole grains supports a healthy immune system. […] Excessive exposure to solar radiation should be avoided to lower the risk of soft tissue sarcoma. It includes going out in the sun only when necessary and using sunscreen lotions.
- #26 Understanding Your Risks of Sarcomahttps://www.stjohns.health/blog/2022/june/understanding-your-risks-of-sarcoma/
Currently, most sarcomas develop in people with no known risk factors which makes prevention vital. There is no sure way to prevent sarcoma, but there are some steps you can take to reduce your risk. […] Quit smoking. Smoking is the most important risk factor for sarcoma, and quitting smoking can greatly reduce your risk. […] Avoid exposure to certain chemicals. Some chemicals, such as dioxins and polychlorinated biphenyls (PCBs), have been linked to an increased risk of sarcoma. […] Limit your exposure to radiation. Exposure to radiation, such as from X-rays, cancer treatment, or CT scans, can increase your risk of sarcoma. If you need an imaging test, talk to your doctor about the risks and benefits. […] Know your family history. If sarcoma runs in your family, you may be at an increased risk. Talk to your doctor about your family history and what you can do to reduce your risk.
- #27 Soft Tissue Sarcoma Risk Factors and Prevention Measureshttps://www.hcgoncology.com/types-of-cancers/soft-tissue-sarcoma-prevention/
Individuals with a family history of soft tissue sarcoma or those who are suffering from genetic syndromes that enhance the risk of soft tissue sarcoma should be provided genetic counseling. Information should be obtained about their risk of developing soft tissue sarcoma. […] Like other cancers, a healthy lifestyle reduces the risk of soft tissue sarcoma. It helps improve the immune system and enhances the body’s ability to fight against abnormal cells. Engaging in regular physical activity may prevent cancer. A well-balanced diet comprising vegetables, fruits, and whole grains supports a healthy immune system. […] Excessive exposure to solar radiation should be avoided to lower the risk of soft tissue sarcoma. It includes going out in the sun only when necessary and using sunscreen lotions.
- #28 Soft Tissue Sarcoma Prevention | Stanford Health Carehttps://stanfordhealthcare.org/medical-conditions/cancer/soft-tissue-sarcoma/prevention.html
Because most people who get soft tissue sarcoma do not have any risk factors, doctors have little advice on how you can prevent this very rare form of cancer. […] Remember, you can have all the risk factors and not get soft tissue sarcoma. Or you can have none of them and get this illness. Talk to your doctor if you are concerned about your risk. […] When possible, you should avoid these risk factors. […] Avoid exposure to radiation. (This may not be possible for people who need radiation to treat cancer.) […] Avoid exposure to certain chemicals, especially herbicides and dioxin. […] If you or anyone in your family has had neurofibromatosis, Li-Fraumeni syndrome, retinoblastoma, or soft tissue sarcoma, you may have a slightly elevated risk of this type of cancer. Ask your doctor if you should be tested for inherited genes that might increase your risk of soft tissue sarcoma. It is important to know that there are not a lot of genetic tests to accurately predict your risk for sarcomas.
- #29 Soft Tissue Sarcoma Prevention | Stanford Health Carehttps://stanfordhealthcare.org/medical-conditions/cancer/soft-tissue-sarcoma/prevention.html
Because most people who get soft tissue sarcoma do not have any risk factors, doctors have little advice on how you can prevent this very rare form of cancer. […] Remember, you can have all the risk factors and not get soft tissue sarcoma. Or you can have none of them and get this illness. Talk to your doctor if you are concerned about your risk. […] When possible, you should avoid these risk factors. […] Avoid exposure to radiation. (This may not be possible for people who need radiation to treat cancer.) […] Avoid exposure to certain chemicals, especially herbicides and dioxin. […] If you or anyone in your family has had neurofibromatosis, Li-Fraumeni syndrome, retinoblastoma, or soft tissue sarcoma, you may have a slightly elevated risk of this type of cancer. Ask your doctor if you should be tested for inherited genes that might increase your risk of soft tissue sarcoma. It is important to know that there are not a lot of genetic tests to accurately predict your risk for sarcomas.
- #30 Understanding Your Risks of Sarcomahttps://www.stjohns.health/blog/2022/june/understanding-your-risks-of-sarcoma/
Currently, most sarcomas develop in people with no known risk factors which makes prevention vital. There is no sure way to prevent sarcoma, but there are some steps you can take to reduce your risk. […] Quit smoking. Smoking is the most important risk factor for sarcoma, and quitting smoking can greatly reduce your risk. […] Avoid exposure to certain chemicals. Some chemicals, such as dioxins and polychlorinated biphenyls (PCBs), have been linked to an increased risk of sarcoma. […] Limit your exposure to radiation. Exposure to radiation, such as from X-rays, cancer treatment, or CT scans, can increase your risk of sarcoma. If you need an imaging test, talk to your doctor about the risks and benefits. […] Know your family history. If sarcoma runs in your family, you may be at an increased risk. Talk to your doctor about your family history and what you can do to reduce your risk.
- #31 Scalp Leiomyosarcoma: Diagnosis and Treatment During a Global Pandemic With COVID-19 | Hassan | World Journal of Oncologyhttps://www.wjon.org/index.php/wjon/article/view/1393/1069
Leiomyosarcoma is an aggressive, uncommon sarcoma effecting smooth muscle tissue. Prompt tissue diagnosis and staging workup are keys to preventing distant metastasis. […] Although diagnosis and treatment for rare cancers have already been difficult, it has become increasingly challenging due to the coronavirus disease of 2019 (COVID-19) pandemic. […] The purpose of this report is to discuss both diagnosis and management of leiomyosarcoma in the scalp to aid physicians navigating cancer care during the pandemic. […] Prompt diagnosis and treatment is crucial to improve overall survival from this challenging disease. […] Cure of leiomyosarcoma depends on early diagnosis and prompt management; if the sarcoma is diagnosed before locally advanced state or distant metastasis, complete tumor excision has potential to be curative.
- #32 Soft Tissue Sarcoma Prevention | Stanford Health Carehttps://stanfordhealthcare.org/medical-conditions/cancer/soft-tissue-sarcoma/prevention.html
Unfortunately, there is no test that can find sarcoma cells when they first begin to grow. However, you have a better chance of surviving soft tissue sarcoma if it is found and treated early. For this reason, it is important to tell your doctor right away if you notice any lumps or other symptoms on your body. If you feel a lump on your body, it is important to have your doctor check it. This is especially true if the lump is causing pain or is getting larger. Even though most lumps are not sarcomas, you can’t assume so. Your doctor may continue to watch the lump or have tests done. […] Don’t be afraid to question your doctor and ask for more tests to make yourself feel better. It is your health and your body and it is important to know confidently that any concern you have has been completely evaluated to your satisfaction.
- #33 Soft Tissue Sarcoma Prevention | Stanford Health Carehttps://stanfordhealthcare.org/medical-conditions/cancer/soft-tissue-sarcoma/prevention.html
Unfortunately, there is no test that can find sarcoma cells when they first begin to grow. However, you have a better chance of surviving soft tissue sarcoma if it is found and treated early. For this reason, it is important to tell your doctor right away if you notice any lumps or other symptoms on your body. If you feel a lump on your body, it is important to have your doctor check it. This is especially true if the lump is causing pain or is getting larger. Even though most lumps are not sarcomas, you can’t assume so. Your doctor may continue to watch the lump or have tests done. […] Don’t be afraid to question your doctor and ask for more tests to make yourself feel better. It is your health and your body and it is important to know confidently that any concern you have has been completely evaluated to your satisfaction.
- #34 Soft Tissue Sarcoma Risk Factors and Prevention Measureshttps://www.hcgoncology.com/types-of-cancers/soft-tissue-sarcoma-prevention/
It is important to consult the oncologists immediately if any symptom may cause concern, especially in people with a high risk for soft tissue sarcoma or individuals with a history of soft tissue sarcoma. Early detection helps with appropriate intervention and improves overall outcomes. […] Soft tissue sarcoma prevention may be achieved through minimizing radiation exposure, safeguarding against chemical exposure, and maintaining a healthy lifestyle. […] Soft tissue sarcoma prevention measures include reduced radiation and chemical exposure, a healthy lifestyle, and routine monitoring.
- #35 Soft Tissue Sarcoma Prevention | Stanford Health Carehttps://stanfordhealthcare.org/medical-conditions/cancer/soft-tissue-sarcoma/prevention.html
Unfortunately, there is no test that can find sarcoma cells when they first begin to grow. However, you have a better chance of surviving soft tissue sarcoma if it is found and treated early. For this reason, it is important to tell your doctor right away if you notice any lumps or other symptoms on your body. If you feel a lump on your body, it is important to have your doctor check it. This is especially true if the lump is causing pain or is getting larger. Even though most lumps are not sarcomas, you can’t assume so. Your doctor may continue to watch the lump or have tests done. […] Don’t be afraid to question your doctor and ask for more tests to make yourself feel better. It is your health and your body and it is important to know confidently that any concern you have has been completely evaluated to your satisfaction.
- #36 Soft Tissue Sarcoma Prevention | Stanford Health Carehttps://stanfordhealthcare.org/medical-conditions/cancer/soft-tissue-sarcoma/prevention.html
Unfortunately, there is no test that can find sarcoma cells when they first begin to grow. However, you have a better chance of surviving soft tissue sarcoma if it is found and treated early. For this reason, it is important to tell your doctor right away if you notice any lumps or other symptoms on your body. If you feel a lump on your body, it is important to have your doctor check it. This is especially true if the lump is causing pain or is getting larger. Even though most lumps are not sarcomas, you can’t assume so. Your doctor may continue to watch the lump or have tests done. […] Don’t be afraid to question your doctor and ask for more tests to make yourself feel better. It is your health and your body and it is important to know confidently that any concern you have has been completely evaluated to your satisfaction.
- #37 Soft Tissue Sarcoma Risk Factors and Prevention Measureshttps://www.hcgoncology.com/types-of-cancers/soft-tissue-sarcoma-prevention/
It is important to consult the oncologists immediately if any symptom may cause concern, especially in people with a high risk for soft tissue sarcoma or individuals with a history of soft tissue sarcoma. Early detection helps with appropriate intervention and improves overall outcomes. […] Soft tissue sarcoma prevention may be achieved through minimizing radiation exposure, safeguarding against chemical exposure, and maintaining a healthy lifestyle. […] Soft tissue sarcoma prevention measures include reduced radiation and chemical exposure, a healthy lifestyle, and routine monitoring.
- #38 Uterine sarcoma: MedlinePlus Medical EncyclopediaLockhttps://medlineplus.gov/ency/article/007655.htm
There is no known way to prevent uterine sarcoma. If you have had radiation therapy in your pelvic area or have taken tamoxifen for breast cancer, ask your provider how often you should be checked for possible problems.
- #39 Soft Tissue Sarcoma Prevention | Stanford Health Carehttps://stanfordhealthcare.org/medical-conditions/cancer/soft-tissue-sarcoma/prevention.html
Unfortunately, there is no test that can find sarcoma cells when they first begin to grow. However, you have a better chance of surviving soft tissue sarcoma if it is found and treated early. For this reason, it is important to tell your doctor right away if you notice any lumps or other symptoms on your body. If you feel a lump on your body, it is important to have your doctor check it. This is especially true if the lump is causing pain or is getting larger. Even though most lumps are not sarcomas, you can’t assume so. Your doctor may continue to watch the lump or have tests done. […] Don’t be afraid to question your doctor and ask for more tests to make yourself feel better. It is your health and your body and it is important to know confidently that any concern you have has been completely evaluated to your satisfaction.
- #40 Uterine sarcoma: MedlinePlus Medical EncyclopediaLockhttps://medlineplus.gov/ency/article/007655.htm
There is no known way to prevent uterine sarcoma. If you have had radiation therapy in your pelvic area or have taken tamoxifen for breast cancer, ask your provider how often you should be checked for possible problems.
- #41 Uterine Sarcoma: Symptoms, Diagnosis, Treatment & Preventionhttps://my.clevelandclinic.org/health/diseases/16408-uterine-sarcoma
We don’t know how to prevent uterine sarcoma yet, but we know about certain risk factors, such as receiving pelvic area radiation and taking tamoxifen for breast cancer. Treatment benefits often outweigh the risks associated with developing uterine sarcoma, especially since it’s so rare. […] Speak to your provider about the risks associated with any cancer treatment, and weigh the pros and cons of the treatment options available.
- #42 Uterine sarcoma: MedlinePlus Medical EncyclopediaLockhttps://medlineplus.gov/ency/article/007655.htm
There is no known way to prevent uterine sarcoma. If you have had radiation therapy in your pelvic area or have taken tamoxifen for breast cancer, ask your provider how often you should be checked for possible problems.
- #43 Uterine sarcoma: MedlinePlus Medical EncyclopediaLockhttps://medlineplus.gov/ency/article/007655.htm
There is no known way to prevent uterine sarcoma. If you have had radiation therapy in your pelvic area or have taken tamoxifen for breast cancer, ask your provider how often you should be checked for possible problems.
- #44 Uterine Sarcoma: Symptoms, Diagnosis, Treatment & Preventionhttps://my.clevelandclinic.org/health/diseases/16408-uterine-sarcoma
We don’t know how to prevent uterine sarcoma yet, but we know about certain risk factors, such as receiving pelvic area radiation and taking tamoxifen for breast cancer. Treatment benefits often outweigh the risks associated with developing uterine sarcoma, especially since it’s so rare. […] Speak to your provider about the risks associated with any cancer treatment, and weigh the pros and cons of the treatment options available.
- #45 Soft Tissue Sarcoma Prevention | Stanford Health Carehttps://stanfordhealthcare.org/medical-conditions/cancer/soft-tissue-sarcoma/prevention.html
Because most people who get soft tissue sarcoma do not have any risk factors, doctors have little advice on how you can prevent this very rare form of cancer. […] Remember, you can have all the risk factors and not get soft tissue sarcoma. Or you can have none of them and get this illness. Talk to your doctor if you are concerned about your risk. […] When possible, you should avoid these risk factors. […] Avoid exposure to radiation. (This may not be possible for people who need radiation to treat cancer.) […] Avoid exposure to certain chemicals, especially herbicides and dioxin. […] If you or anyone in your family has had neurofibromatosis, Li-Fraumeni syndrome, retinoblastoma, or soft tissue sarcoma, you may have a slightly elevated risk of this type of cancer. Ask your doctor if you should be tested for inherited genes that might increase your risk of soft tissue sarcoma. It is important to know that there are not a lot of genetic tests to accurately predict your risk for sarcomas.
- #46 A case of spermatic cord leiomyosarcoma: Clinical presentation, treatment and literature review | Applied Radiation Oncologyhttps://www.appliedradiationoncology.com/articles/a-case-of-spermatic-cord-leiomyosarcoma-clinical-presentation-treatment-and-literature-review
The primary treatment is surgical resection with radical orchiectomy and high ligation of the spermatic cord. Prophylactic retroperitoneal lymphadenectomy is not necessary unless there is evidence of nodal involvement or for sarcomatous histologies with a propensity for nodal metastasis, such as rhabdomyosarcoma. […] Postoperatively, there are no well-established data on adjuvant therapy. […] In summary, this data from retrospective studies comprised of relatively few subjects demonstrated that local recurrence rates significantly decreased with adjuvant radiation therapy from 37%-30% down to 0. […] However, due to high risk of local failure, radiation therapy should be recommended for high-grade tumors, or close or positive margins. […] Adjuvant radiation should be recommended for higher grade tumors or close/positive margins to improve local control. Systemic chemotherapy may be beneficial to decrease the rate of distant metastasis and improve potential survival.
- #47 Scalp Leiomyosarcoma: Diagnosis and Treatment During a Global Pandemic With COVID-19 | Hassan | World Journal of Oncologyhttps://www.wjon.org/index.php/wjon/article/view/1393/1069
Leiomyosarcoma is an aggressive, uncommon sarcoma effecting smooth muscle tissue. Prompt tissue diagnosis and staging workup are keys to preventing distant metastasis. […] Although diagnosis and treatment for rare cancers have already been difficult, it has become increasingly challenging due to the coronavirus disease of 2019 (COVID-19) pandemic. […] The purpose of this report is to discuss both diagnosis and management of leiomyosarcoma in the scalp to aid physicians navigating cancer care during the pandemic. […] Prompt diagnosis and treatment is crucial to improve overall survival from this challenging disease. […] Cure of leiomyosarcoma depends on early diagnosis and prompt management; if the sarcoma is diagnosed before locally advanced state or distant metastasis, complete tumor excision has potential to be curative.
- #48 A case of spermatic cord leiomyosarcoma: Clinical presentation, treatment and literature review | Applied Radiation Oncologyhttps://www.appliedradiationoncology.com/articles/a-case-of-spermatic-cord-leiomyosarcoma-clinical-presentation-treatment-and-literature-review
The primary treatment is surgical resection with radical orchiectomy and high ligation of the spermatic cord. Prophylactic retroperitoneal lymphadenectomy is not necessary unless there is evidence of nodal involvement or for sarcomatous histologies with a propensity for nodal metastasis, such as rhabdomyosarcoma. […] Postoperatively, there are no well-established data on adjuvant therapy. […] In summary, this data from retrospective studies comprised of relatively few subjects demonstrated that local recurrence rates significantly decreased with adjuvant radiation therapy from 37%-30% down to 0. […] However, due to high risk of local failure, radiation therapy should be recommended for high-grade tumors, or close or positive margins. […] Adjuvant radiation should be recommended for higher grade tumors or close/positive margins to improve local control. Systemic chemotherapy may be beneficial to decrease the rate of distant metastasis and improve potential survival.
- #49 Scalp Leiomyosarcoma: Diagnosis and Treatment During a Global Pandemic With COVID-19 | Hassan | World Journal of Oncologyhttps://www.wjon.org/index.php/wjon/article/view/1393/1069
It is also proposed that adjuvant radiotherapy may reduce risk of local recurrence in surgically treated head and neck leiomyosarcoma, even in the absence of positive margins. […] Had our patient sought care earlier and if he had been able to have proper appointments with regular follow-up, the diagnosis may have been obtained much sooner. […] Due to COVID-19, the healthcare system had to be modified to accommodate increasing volume of patients with COVID-19 infection. […] An elective surgery acuity scale has been issued by the American College of Surgeons to help distinguish which patients should proceed to surgery based on urgency and patient health as precautions for patient safety from COVID-19 infection. […] Prompt cancer diagnosis has been affected because of limited primary care visits as well as cancer screening procedures due to patient reluctance towards routine office visits and less capacity for non-COVID care.
- #50 A case of spermatic cord leiomyosarcoma: Clinical presentation, treatment and literature review | Applied Radiation Oncologyhttps://www.appliedradiationoncology.com/articles/a-case-of-spermatic-cord-leiomyosarcoma-clinical-presentation-treatment-and-literature-review
The primary treatment is surgical resection with radical orchiectomy and high ligation of the spermatic cord. Prophylactic retroperitoneal lymphadenectomy is not necessary unless there is evidence of nodal involvement or for sarcomatous histologies with a propensity for nodal metastasis, such as rhabdomyosarcoma. […] Postoperatively, there are no well-established data on adjuvant therapy. […] In summary, this data from retrospective studies comprised of relatively few subjects demonstrated that local recurrence rates significantly decreased with adjuvant radiation therapy from 37%-30% down to 0. […] However, due to high risk of local failure, radiation therapy should be recommended for high-grade tumors, or close or positive margins. […] Adjuvant radiation should be recommended for higher grade tumors or close/positive margins to improve local control. Systemic chemotherapy may be beneficial to decrease the rate of distant metastasis and improve potential survival.
- #51 Scalp Leiomyosarcoma: Diagnosis and Treatment During a Global Pandemic With COVID-19 | Hassan | World Journal of Oncologyhttps://www.wjon.org/index.php/wjon/article/view/1393/1069
It is also proposed that adjuvant radiotherapy may reduce risk of local recurrence in surgically treated head and neck leiomyosarcoma, even in the absence of positive margins. […] Had our patient sought care earlier and if he had been able to have proper appointments with regular follow-up, the diagnosis may have been obtained much sooner. […] Due to COVID-19, the healthcare system had to be modified to accommodate increasing volume of patients with COVID-19 infection. […] An elective surgery acuity scale has been issued by the American College of Surgeons to help distinguish which patients should proceed to surgery based on urgency and patient health as precautions for patient safety from COVID-19 infection. […] Prompt cancer diagnosis has been affected because of limited primary care visits as well as cancer screening procedures due to patient reluctance towards routine office visits and less capacity for non-COVID care.
- #52 A case of spermatic cord leiomyosarcoma: Clinical presentation, treatment and literature review | Applied Radiation Oncologyhttps://www.appliedradiationoncology.com/articles/a-case-of-spermatic-cord-leiomyosarcoma-clinical-presentation-treatment-and-literature-review
The primary treatment is surgical resection with radical orchiectomy and high ligation of the spermatic cord. Prophylactic retroperitoneal lymphadenectomy is not necessary unless there is evidence of nodal involvement or for sarcomatous histologies with a propensity for nodal metastasis, such as rhabdomyosarcoma. […] Postoperatively, there are no well-established data on adjuvant therapy. […] In summary, this data from retrospective studies comprised of relatively few subjects demonstrated that local recurrence rates significantly decreased with adjuvant radiation therapy from 37%-30% down to 0. […] However, due to high risk of local failure, radiation therapy should be recommended for high-grade tumors, or close or positive margins. […] Adjuvant radiation should be recommended for higher grade tumors or close/positive margins to improve local control. Systemic chemotherapy may be beneficial to decrease the rate of distant metastasis and improve potential survival.
- #53 A case of spermatic cord leiomyosarcoma: Clinical presentation, treatment and literature review | Applied Radiation Oncologyhttps://www.appliedradiationoncology.com/articles/a-case-of-spermatic-cord-leiomyosarcoma-clinical-presentation-treatment-and-literature-review
The primary treatment is surgical resection with radical orchiectomy and high ligation of the spermatic cord. Prophylactic retroperitoneal lymphadenectomy is not necessary unless there is evidence of nodal involvement or for sarcomatous histologies with a propensity for nodal metastasis, such as rhabdomyosarcoma. […] Postoperatively, there are no well-established data on adjuvant therapy. […] In summary, this data from retrospective studies comprised of relatively few subjects demonstrated that local recurrence rates significantly decreased with adjuvant radiation therapy from 37%-30% down to 0. […] However, due to high risk of local failure, radiation therapy should be recommended for high-grade tumors, or close or positive margins. […] Adjuvant radiation should be recommended for higher grade tumors or close/positive margins to improve local control. Systemic chemotherapy may be beneficial to decrease the rate of distant metastasis and improve potential survival.
- #54 Scalp Leiomyosarcoma: Diagnosis and Treatment During a Global Pandemic With COVID-19 | Hassan | World Journal of Oncologyhttps://www.wjon.org/index.php/wjon/article/view/1393/1069
Leiomyosarcoma is an aggressive, uncommon sarcoma effecting smooth muscle tissue. Prompt tissue diagnosis and staging workup are keys to preventing distant metastasis. […] Although diagnosis and treatment for rare cancers have already been difficult, it has become increasingly challenging due to the coronavirus disease of 2019 (COVID-19) pandemic. […] The purpose of this report is to discuss both diagnosis and management of leiomyosarcoma in the scalp to aid physicians navigating cancer care during the pandemic. […] Prompt diagnosis and treatment is crucial to improve overall survival from this challenging disease. […] Cure of leiomyosarcoma depends on early diagnosis and prompt management; if the sarcoma is diagnosed before locally advanced state or distant metastasis, complete tumor excision has potential to be curative.
- #55 Scalp Leiomyosarcoma: Diagnosis and Treatment During a Global Pandemic With COVID-19 | Hassan | World Journal of Oncologyhttps://www.wjon.org/index.php/wjon/article/view/1393/1069
It is also proposed that adjuvant radiotherapy may reduce risk of local recurrence in surgically treated head and neck leiomyosarcoma, even in the absence of positive margins. […] Had our patient sought care earlier and if he had been able to have proper appointments with regular follow-up, the diagnosis may have been obtained much sooner. […] Due to COVID-19, the healthcare system had to be modified to accommodate increasing volume of patients with COVID-19 infection. […] An elective surgery acuity scale has been issued by the American College of Surgeons to help distinguish which patients should proceed to surgery based on urgency and patient health as precautions for patient safety from COVID-19 infection. […] Prompt cancer diagnosis has been affected because of limited primary care visits as well as cancer screening procedures due to patient reluctance towards routine office visits and less capacity for non-COVID care.
- #56 Scalp Leiomyosarcoma: Diagnosis and Treatment During a Global Pandemic With COVID-19 | Hassan | World Journal of Oncologyhttps://www.wjon.org/index.php/wjon/article/view/1393/1069
It is also proposed that adjuvant radiotherapy may reduce risk of local recurrence in surgically treated head and neck leiomyosarcoma, even in the absence of positive margins. […] Had our patient sought care earlier and if he had been able to have proper appointments with regular follow-up, the diagnosis may have been obtained much sooner. […] Due to COVID-19, the healthcare system had to be modified to accommodate increasing volume of patients with COVID-19 infection. […] An elective surgery acuity scale has been issued by the American College of Surgeons to help distinguish which patients should proceed to surgery based on urgency and patient health as precautions for patient safety from COVID-19 infection. […] Prompt cancer diagnosis has been affected because of limited primary care visits as well as cancer screening procedures due to patient reluctance towards routine office visits and less capacity for non-COVID care.
- #57 Scalp Leiomyosarcoma: Diagnosis and Treatment During a Global Pandemic With COVID-19 | Hassan | World Journal of Oncologyhttps://www.wjon.org/index.php/wjon/article/view/1393/1069
It is also proposed that adjuvant radiotherapy may reduce risk of local recurrence in surgically treated head and neck leiomyosarcoma, even in the absence of positive margins. […] Had our patient sought care earlier and if he had been able to have proper appointments with regular follow-up, the diagnosis may have been obtained much sooner. […] Due to COVID-19, the healthcare system had to be modified to accommodate increasing volume of patients with COVID-19 infection. […] An elective surgery acuity scale has been issued by the American College of Surgeons to help distinguish which patients should proceed to surgery based on urgency and patient health as precautions for patient safety from COVID-19 infection. […] Prompt cancer diagnosis has been affected because of limited primary care visits as well as cancer screening procedures due to patient reluctance towards routine office visits and less capacity for non-COVID care.
- #58 Scalp Leiomyosarcoma: Diagnosis and Treatment During a Global Pandemic With COVID-19 | Hassan | World Journal of Oncologyhttps://www.wjon.org/index.php/wjon/article/view/1393/1069
It is also proposed that adjuvant radiotherapy may reduce risk of local recurrence in surgically treated head and neck leiomyosarcoma, even in the absence of positive margins. […] Had our patient sought care earlier and if he had been able to have proper appointments with regular follow-up, the diagnosis may have been obtained much sooner. […] Due to COVID-19, the healthcare system had to be modified to accommodate increasing volume of patients with COVID-19 infection. […] An elective surgery acuity scale has been issued by the American College of Surgeons to help distinguish which patients should proceed to surgery based on urgency and patient health as precautions for patient safety from COVID-19 infection. […] Prompt cancer diagnosis has been affected because of limited primary care visits as well as cancer screening procedures due to patient reluctance towards routine office visits and less capacity for non-COVID care.
- #59 Scalp Leiomyosarcoma: Diagnosis and Treatment During a Global Pandemic With COVID-19 | Hassan | World Journal of Oncologyhttps://www.wjon.org/index.php/wjon/article/view/1393/1069
It is also proposed that adjuvant radiotherapy may reduce risk of local recurrence in surgically treated head and neck leiomyosarcoma, even in the absence of positive margins. […] Had our patient sought care earlier and if he had been able to have proper appointments with regular follow-up, the diagnosis may have been obtained much sooner. […] Due to COVID-19, the healthcare system had to be modified to accommodate increasing volume of patients with COVID-19 infection. […] An elective surgery acuity scale has been issued by the American College of Surgeons to help distinguish which patients should proceed to surgery based on urgency and patient health as precautions for patient safety from COVID-19 infection. […] Prompt cancer diagnosis has been affected because of limited primary care visits as well as cancer screening procedures due to patient reluctance towards routine office visits and less capacity for non-COVID care.
- #60 Scalp Leiomyosarcoma: Diagnosis and Treatment During a Global Pandemic With COVID-19 | Hassan | World Journal of Oncologyhttps://www.wjon.org/index.php/wjon/article/view/1393/1069
There is clear evidence supporting the claim that an increase in age is associated with higher rates of comorbidities with COVID-19, leading to this fear. […] As a result of such panic, these patients are reluctant to schedule an appointment which is essential in diagnosing a treatable cancer. […] COVID-19 constraints tend to defer face-to-face visits with physicians, due to inadequate physician protective equipment, lockdown, and risk of spread. […] With telemedicine, potential disease exposure is minimized for both the patient and the healthcare provider, allowing patients to receive timely care. […] Both cancer and COVID-19 present great risk to patients; it is important to weigh the risks and benefits associated with cancer care during the pandemic.
- #61 Scalp Leiomyosarcoma: Diagnosis and Treatment During a Global Pandemic With COVID-19 | Hassan | World Journal of Oncologyhttps://www.wjon.org/index.php/wjon/article/view/1393/1069
There is clear evidence supporting the claim that an increase in age is associated with higher rates of comorbidities with COVID-19, leading to this fear. […] As a result of such panic, these patients are reluctant to schedule an appointment which is essential in diagnosing a treatable cancer. […] COVID-19 constraints tend to defer face-to-face visits with physicians, due to inadequate physician protective equipment, lockdown, and risk of spread. […] With telemedicine, potential disease exposure is minimized for both the patient and the healthcare provider, allowing patients to receive timely care. […] Both cancer and COVID-19 present great risk to patients; it is important to weigh the risks and benefits associated with cancer care during the pandemic.
- #62 Scalp Leiomyosarcoma: Diagnosis and Treatment During a Global Pandemic With COVID-19 | Hassan | World Journal of Oncologyhttps://www.wjon.org/index.php/wjon/article/view/1393/1069
There is clear evidence supporting the claim that an increase in age is associated with higher rates of comorbidities with COVID-19, leading to this fear. […] As a result of such panic, these patients are reluctant to schedule an appointment which is essential in diagnosing a treatable cancer. […] COVID-19 constraints tend to defer face-to-face visits with physicians, due to inadequate physician protective equipment, lockdown, and risk of spread. […] With telemedicine, potential disease exposure is minimized for both the patient and the healthcare provider, allowing patients to receive timely care. […] Both cancer and COVID-19 present great risk to patients; it is important to weigh the risks and benefits associated with cancer care during the pandemic.
- #63 Scalp Leiomyosarcoma: Diagnosis and Treatment During a Global Pandemic With COVID-19 | Hassan | World Journal of Oncologyhttps://www.wjon.org/index.php/wjon/article/view/1393/1069
There is clear evidence supporting the claim that an increase in age is associated with higher rates of comorbidities with COVID-19, leading to this fear. […] As a result of such panic, these patients are reluctant to schedule an appointment which is essential in diagnosing a treatable cancer. […] COVID-19 constraints tend to defer face-to-face visits with physicians, due to inadequate physician protective equipment, lockdown, and risk of spread. […] With telemedicine, potential disease exposure is minimized for both the patient and the healthcare provider, allowing patients to receive timely care. […] Both cancer and COVID-19 present great risk to patients; it is important to weigh the risks and benefits associated with cancer care during the pandemic.
- #64 Sarcoma Risk Factors & Prevention | Banner MD Andersonhttps://www.bannerhealth.com/services/cancer/cancer-type/sarcoma/risk-factors-and-prevention
Currently, there is no known way to prevent sarcoma. Avoiding exposure to risk factors whenever possible is an option, but most sarcomas develop in people with no known risk factors. […] Not everyone with these risk factors develop sarcoma. If you have any risk factors, discuss them with your doctor at Banner MD Anderson.
- #65https://winshipcancer.emory.edu/cancer-types-and-treatments/sarcoma/prevention.php
Prevention is not yet possible for sarcomas, but Winships team of experts continues to work on sarcoma prevention to give you the best outcomes possible. […] The vast majority of sarcomas are sporadic, meaning they occur at random with no known way to prevent them. […] While sarcomas cannot be prevented, there are ways to effectively diagnose and treat them. […] Sarcoma prevention does not yet exist. According to experts, there are no lifestyle-related or environmental causes of sarcoma, which means that there is no determined way to prevent these tumors from forming.
- #66 Soft Tissue Sarcoma Risk Factors and Prevention Measureshttps://www.hcgoncology.com/types-of-cancers/soft-tissue-sarcoma-prevention/
It is important to consult the oncologists immediately if any symptom may cause concern, especially in people with a high risk for soft tissue sarcoma or individuals with a history of soft tissue sarcoma. Early detection helps with appropriate intervention and improves overall outcomes. […] Soft tissue sarcoma prevention may be achieved through minimizing radiation exposure, safeguarding against chemical exposure, and maintaining a healthy lifestyle. […] Soft tissue sarcoma prevention measures include reduced radiation and chemical exposure, a healthy lifestyle, and routine monitoring.
- #67 Uterine Sarcoma: Symptoms, Diagnosis, Treatment & Preventionhttps://my.clevelandclinic.org/health/diseases/16408-uterine-sarcoma
We don’t know how to prevent uterine sarcoma yet, but we know about certain risk factors, such as receiving pelvic area radiation and taking tamoxifen for breast cancer. Treatment benefits often outweigh the risks associated with developing uterine sarcoma, especially since it’s so rare. […] Speak to your provider about the risks associated with any cancer treatment, and weigh the pros and cons of the treatment options available.
- #68 Uterine sarcoma: MedlinePlus Medical EncyclopediaLockhttps://medlineplus.gov/ency/article/007655.htm
There is no known way to prevent uterine sarcoma. If you have had radiation therapy in your pelvic area or have taken tamoxifen for breast cancer, ask your provider how often you should be checked for possible problems.
- #69 Soft Tissue Sarcoma Prevention | Stanford Health Carehttps://stanfordhealthcare.org/medical-conditions/cancer/soft-tissue-sarcoma/prevention.html
Because most people who get soft tissue sarcoma do not have any risk factors, doctors have little advice on how you can prevent this very rare form of cancer. […] Remember, you can have all the risk factors and not get soft tissue sarcoma. Or you can have none of them and get this illness. Talk to your doctor if you are concerned about your risk. […] When possible, you should avoid these risk factors. […] Avoid exposure to radiation. (This may not be possible for people who need radiation to treat cancer.) […] Avoid exposure to certain chemicals, especially herbicides and dioxin. […] If you or anyone in your family has had neurofibromatosis, Li-Fraumeni syndrome, retinoblastoma, or soft tissue sarcoma, you may have a slightly elevated risk of this type of cancer. Ask your doctor if you should be tested for inherited genes that might increase your risk of soft tissue sarcoma. It is important to know that there are not a lot of genetic tests to accurately predict your risk for sarcomas.
- #70 A case of spermatic cord leiomyosarcoma: Clinical presentation, treatment and literature review | Applied Radiation Oncologyhttps://www.appliedradiationoncology.com/articles/a-case-of-spermatic-cord-leiomyosarcoma-clinical-presentation-treatment-and-literature-review
The primary treatment is surgical resection with radical orchiectomy and high ligation of the spermatic cord. Prophylactic retroperitoneal lymphadenectomy is not necessary unless there is evidence of nodal involvement or for sarcomatous histologies with a propensity for nodal metastasis, such as rhabdomyosarcoma. […] Postoperatively, there are no well-established data on adjuvant therapy. […] In summary, this data from retrospective studies comprised of relatively few subjects demonstrated that local recurrence rates significantly decreased with adjuvant radiation therapy from 37%-30% down to 0. […] However, due to high risk of local failure, radiation therapy should be recommended for high-grade tumors, or close or positive margins. […] Adjuvant radiation should be recommended for higher grade tumors or close/positive margins to improve local control. Systemic chemotherapy may be beneficial to decrease the rate of distant metastasis and improve potential survival.
- #71 Scalp Leiomyosarcoma: Diagnosis and Treatment During a Global Pandemic With COVID-19 | Hassan | World Journal of Oncologyhttps://www.wjon.org/index.php/wjon/article/view/1393/1069
It is also proposed that adjuvant radiotherapy may reduce risk of local recurrence in surgically treated head and neck leiomyosarcoma, even in the absence of positive margins. […] Had our patient sought care earlier and if he had been able to have proper appointments with regular follow-up, the diagnosis may have been obtained much sooner. […] Due to COVID-19, the healthcare system had to be modified to accommodate increasing volume of patients with COVID-19 infection. […] An elective surgery acuity scale has been issued by the American College of Surgeons to help distinguish which patients should proceed to surgery based on urgency and patient health as precautions for patient safety from COVID-19 infection. […] Prompt cancer diagnosis has been affected because of limited primary care visits as well as cancer screening procedures due to patient reluctance towards routine office visits and less capacity for non-COVID care.
- #72 Scalp Leiomyosarcoma: Diagnosis and Treatment During a Global Pandemic With COVID-19 | Hassan | World Journal of Oncologyhttps://www.wjon.org/index.php/wjon/article/view/1393/1069
It is also proposed that adjuvant radiotherapy may reduce risk of local recurrence in surgically treated head and neck leiomyosarcoma, even in the absence of positive margins. […] Had our patient sought care earlier and if he had been able to have proper appointments with regular follow-up, the diagnosis may have been obtained much sooner. […] Due to COVID-19, the healthcare system had to be modified to accommodate increasing volume of patients with COVID-19 infection. […] An elective surgery acuity scale has been issued by the American College of Surgeons to help distinguish which patients should proceed to surgery based on urgency and patient health as precautions for patient safety from COVID-19 infection. […] Prompt cancer diagnosis has been affected because of limited primary care visits as well as cancer screening procedures due to patient reluctance towards routine office visits and less capacity for non-COVID care.
- #73 Scalp Leiomyosarcoma: Diagnosis and Treatment During a Global Pandemic With COVID-19 | Hassan | World Journal of Oncologyhttps://www.wjon.org/index.php/wjon/article/view/1393/1069
There is clear evidence supporting the claim that an increase in age is associated with higher rates of comorbidities with COVID-19, leading to this fear. […] As a result of such panic, these patients are reluctant to schedule an appointment which is essential in diagnosing a treatable cancer. […] COVID-19 constraints tend to defer face-to-face visits with physicians, due to inadequate physician protective equipment, lockdown, and risk of spread. […] With telemedicine, potential disease exposure is minimized for both the patient and the healthcare provider, allowing patients to receive timely care. […] Both cancer and COVID-19 present great risk to patients; it is important to weigh the risks and benefits associated with cancer care during the pandemic.