Materiały źródłowe

• #1 Prevention of Recurrent Pericarditis With Colchicine in 2012

  https://pmc.ncbi.nlm.nih.gov/articles/PMC6649517/

  The optimal method for prevention has not been fully established; accepted modalities include nonsteroidal antiinflammatory drugs, corticosteroids, immunosuppressive agents, and pericardiectomy. […] Over the last years, objective clinical evidence has matured and clearly indicates the important role and beneficial clinical effect of colchicine therapy in preventing recurrent pericarditis caused by various etiologies. […] Colchicine is a safe and effective modality for the treatment and prevention of recurrent pericarditis, especially as an adjunct to other modalities, because it provides a sustained benefit, superior to all current modalities. […] The use of colchicine in addition to an NSAID or as monotherapy for RP was given a class I recommendation by the 2004 European Society of Cardiology guidelines.

• #1 The Use of Colchicine in Pericardial Diseases

  https://www.acc.org/Latest-in-Cardiology/Articles/2019/12/04/08/22/The-Use-of-Colchicine-in-Pericardial-Diseases

  Colchicine is currently recommended for all patients who have a first episode for pericarditis for a duration of 3 months. […] The 2015 ESC guidelines recommend colchicine for 6 months in recurrent pericarditis with level IA recommendation and is based on three important randomized trials including: COlchicine for REcurrent pericarditis (CORE), COlchicine for Recurrent Pericarditis (CORP) and efficacy and safety of colchicine for treatment of multiple recurrences of pericarditis (CORP-2), once again orchestrated by Dr. Imazio and his team. […] The addition of colchicine therapy on post-operative day 3 was associated with a significant reduction in the incidence of PPS when compared to the placebo group (16% and 38% respectively with a relative risk reduction of 57.9% (95% CI 27.375.6; P=0.002).

• #1 Prevention of Recurrent Pericarditis With Colchicine in 2012

  https://pmc.ncbi.nlm.nih.gov/articles/PMC6649517/

  Colchicine regimen: recommendations of the European Society of Cardiology: […] Recurrent pericarditis patients should be treated with aspirin or another nonsteroidal antiinflammatory drug plus colchicine (12 mg on the first day, followed by 0.5 once or twice daily for 6 months). […] Maintenance/prophylactic dose should be reduced by 50% in individuals age 70 years and in patients with glomerular filtration rates 50 mL/minute. […] All patients should undergo a careful monitoring of possible side effects, including blood analyses (transaminases, serum creatinine, creatine kinase, and blood cell count) before initiation of therapy, and after at least 1 month of treatment.

• #1 Meta-analysis for the value of colchicine for the therapy of pericarditis and of postpericardiotomy syndrome | BMC Cardiovascular Disorders | Full Text

  https://bmccardiovascdisord.biomedcentral.com/articles/10.1186/s12872-019-1190-4

  Colchicine has been used as anti-inflammatory agent in pericardial effusion (PE). […] Colchicine reduced the recurrence rate of pericarditis in patients with acute and recurrent pericarditis and reduced the incidence of PPS (RR: 0.57, 95% CI: 0.440.74). […] The reported number needed to treat (NNT) for the prevention of recurrent pericarditis ranged between 3 and 5. The reported NNT for PPS prevention was 10, and the number needed to harm (NNH) was 12, respectively. […] Our meta-analysis confirms that colchicine is efficacious and safe for prevention of recurrent pericarditis and PPS, while it reduces rehospitalizations and symptom duration in pericarditis. […] In view of the high incidence of pericarditis recurrence and PPS there is a need for effective treatment in order to prevent recurrence and improve quality of life.

• #1 Prevention of pericardial complications after cardiac surgery: myth or reality? | Heart

  https://heart.bmj.com/cgi/content/short/heartjnl-2024-325565v1?rss=1

  Pericardial complications are very common following cardiac surgery. It is estimated that up to 3040% of patients may develop a postpericardiotomy syndrome (PPS) and 5060% of patients show pericardial effusions after cardiac surgery. […] On this basis, prevention of pericardial postoperative complications is of paramount importance in clinical practice. […] The aim of the present systematic review by Malektojari et al is to evaluate the efficacy and safety of proposed preventive strategies for the prevention of such complications with a main focus on PPS, pericardial effusion, pericarditis and POAF.

• #1 The Use of Colchicine in Pericardial Diseases

  https://www.acc.org/Latest-in-Cardiology/Articles/2019/12/04/08/22/The-Use-of-Colchicine-in-Pericardial-Diseases

  Pre-operative colchicine therapy was associated with a significant reduction in the incidence of PPS compared to placebo (19.4% and 29.4% respectively (95% CI 1.1-18.7, P=0.46). […] Despite this reassuring evidence supporting the use of colchicine for PPS, it is currently rarely used as prophylaxis following cardiac surgery.

• #1 Take Control of Recurrent Pericarditis

  https://www.arcalyst.com/take-control

  ARCALYST is the first and only FDA-approved treatment for recurrent pericarditis in people 12 years and older. Its also proven to prevent future flares. […] 98% Reduction in risk of flares in those who continued treatment vs those who suspended treatment. […] ARCALYST may be used until the cycle of autoinflammation has resolved. […] If you experience another flare after you have a first one, ask your doctor about ARCALYST.

• #1 Pericarditis – Symptoms and causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/pericarditis/symptoms-causes/syc-20352510

  There’s no specific way to prevent pericarditis. But you can take these steps to prevent infections, which might help lower the risk of heart inflammation: […] Stay away from people who have a viral or flu-like illness until they’ve recovered. If you’re sick with symptoms of a viral infection, try not to expose others. For instance, cover your mouth when you sneeze or cough. […] Follow good hygiene. Regular hand-washing can help prevent spreading illness. Scrub your hands with soap and water for at least 20 seconds. […] Get recommended vaccines. Stay up to date on the recommended vaccines, including those that protect against COVID-19, rubella and influenza. These are examples of viral diseases that can cause inflammation of the heart muscle, called myocarditis. Myocarditis and pericarditis can happen together due to a viral infection. Rarely, the COVID-19 vaccine can cause pericarditis and myocarditis, especially in males ages 12 through 17. Talk to your healthcare professional about the benefits and risks of vaccines.

• #1 Pericarditis – Harvard Health

  https://www.health.harvard.edu/a_to_z/pericarditis-a-to-z

  Because pericarditis can be the result of so many very different illnesses, there are no routine guidelines to prevent the condition. You can help prevent pericarditis caused by infections by practicing good hygiene, especially washing your hands often, and by keeping up with recommended immunizations. […] To prevent pericarditis caused by heart attack, you can reduce your risk of coronary artery disease by not smoking, eating a healthy diet, exercising regularly, lowering LDL cholesterol and controlling blood pressure. […] To reduce your risk of trauma-related pericarditis, you should wear a seat belt whenever you drive and wear appropriate chest-protecting equipment when you play contact sports.

• #1 Pericarditis + 6 Natural Ways to Help Manage Recovery – Dr. Axe

  https://draxe.com/health/pericarditis/

  Prevention and Recovery […] 1. Rest and Reduce Stress […] Any type of bodily stress, including intense exercise and physical activity beyond walking and stretching, can be harmful during pericarditis. Its recommended that you take it easy while you heal, so be sure to get plenty of sleep every night (at least seven to nine hours) and to rest when needed. […] Exercise can be beneficial once you’ve healed enough since it benefits immune function, circulation and cardiovascular health. […] 2. Eat An Anti-Inflammatory Diet […] Support your immune system by cutting out processed foods from your diet and eating whole, nutrient-dense foods that provide antioxidants, vitamins and minerals. […] Here are steps you can take to reduce inflammation by eating a nutrient-dense diet: Eat plenty of raw fruits and vegetables. Include foods high in vitamin C and A like oranges, kale and other leafy greens, kiwi, strawberries, grapefruit, red peppers, green peppers, guava and broccoli. […] Avoid inflammatory foods that can worsen existing health conditions, including processed grains (especially those gaining gluten), conventional dairy products, foods with added sugar and synthetic ingredients, processed meats, fast food and fried foods.

• #1 Pericarditis: Causes, Symptoms and Treatment

  https://my.clevelandclinic.org/health/diseases/17353-pericarditis

  Although you cant prevent acute pericarditis, getting quick treatment and sticking with it can help you reduce your risk of getting it again. […] Continuing with your treatment can help you prevent pericarditis from happening again. That’s why it’s important to keep taking prescribed medicines and go to all of your follow-up appointments.

• #1 Management of acute pericarditis: treatment and follow-up

  https://www.escardio.org/Journals/E-Journal-of-Cardiology-Practice/Volume-15/Management-of-acute-pericarditis-treatment-and-follow-up

  Colchicine is recommended as first-line therapy for acute pericarditis as an adjunct to aspirin/NSAIDs therapy for three months. […] Corticosteroids are not recommended as first-line therapy for acute pericarditis as they appear to encourage recurrences. […] Exercise restriction should be considered for non-athletes with acute pericarditis until resolution of symptoms and normalisation of CRP, ECG and echocardiogram. […] For athletes, the duration of exercise restriction should be considered until resolution of symptoms and normalisation of CRP, ECG and echocardiogram – at least 3 months is recommended. […] Therapy duration is symptoms-and-CRP guided, but generally one to two weeks for uncomplicated cases. […] Colchicine is added on top of aspirin or NSAIDs. […] Corticosteroids should be considered as a second option in patients with contraindications and failure of aspirin or NSAIDs because of the risk of favouring the chronic evolution of the disease and promoting drug dependence.

• #1 Management of acute pericarditis: treatment and follow-up

  https://www.escardio.org/Journals/E-Journal-of-Cardiology-Practice/Volume-15/Management-of-acute-pericarditis-treatment-and-follow-up

  If corticosteroids are used, their tapering should be particularly slow. […] After obtaining a complete response, tapering should be done with a single class of drug at a time before colchicine is gradually discontinued (over several months in the most difficult cases). […] Each tapering should be attempted only if symptoms are absent and CRP is normal.

• #1 Efficacy and safety of colchicine for pericarditis prevention. Systematic review and meta-analysis | Heart

  https://heart.bmj.com/content/98/14/1078

  The purpose of this study was to investigate the efficacy and safety of colchicine for pericarditis prevention. […] Although empiric anti-inflammatory therapy is considered the mainstay of treatment, no specific drug has been proven to be efficacious for prevention but colchicine. […] Available evidence suggests that colchicine is safe and efficacious for the primary and secondary prevention of pericarditis. […] Colchicine use was associated with a reduced risk of pericarditis during follow-up either for primary or secondary prevention without a significant higher risk of adverse events compared with placebo. […] Colchicine was efficacious either for the primary or secondary prevention of pericarditis. […] At present colchicine is the only drug that has been proven efficacious and safe for pericarditis prevention in clinical trials, with a similar effect for primary and secondary prevention. […] On this basis, the drug should be considered as a first line agent for pericarditis prevention.

• #2 Prevention and Treatment of Pericarditis | American Heart Association

  http://ma77.net/prevention-and-treatment-of-pericarditis.html

  Acute pericarditis can’t be prevented. You and your doctor can take steps to reduce your chance of having another acute episode, complications or chronic pericarditis. These steps include getting prompt treatment, following your treatment plan and getting ongoing medical care as needed. […] Full recovery is most likely with rest and ongoing care, which can help reduce your risk of getting it again.

• #2 Meta-analysis for the value of colchicine for the therapy of pericarditis and of postpericardiotomy syndrome | BMC Cardiovascular Disorders | Full Text

  https://bmccardiovascdisord.biomedcentral.com/articles/10.1186/s12872-019-1190-4

  In the latest 2015 ESC Guidelines for the diagnosis and management of pericardial diseases, colchicine is recommended as first-line therapy for acute and recurrent pericarditis, as well as for the acute treatment of PPS. […] Colchicine was shown to reduce the overall risk of PE in PC and recurrent pericarditis, and in PPS (all 10 studies) compared with placebo (RR: 0.57; 95% CI: 0.440.74). […] The reported number needed to treat (NNT) for the prevention of recurrent pericarditis was 3 and 5, respectively. […] Although colchicine is effective in reducing the risk of PPS, as well as the rehospitalization rate after PPS, it was not associated with a significant reduction of postoperative PE in comparison to placebo. […] The clinical use of colchicine for the setting of PPS and of postoperative PE should be investigated in further multicenter RCT.

• #2 Colchicine proves 'safe and effective’ in the prevention of recurrent pericarditis

  https://medicalxpress.com/news/2011-08-colchicine-safe-effective-recurrent-pericarditis.html

  Colchicine, when given in addition to conventional therapy, was more effective than placebo in reducing the incidence of recurrence and the persistence of symptoms of pericarditis in a randomised controlled trial. […] There has been some preliminary data from non-randomised observational studies and two single-centre open-label randomised studies suggesting that colchicine may be a safe and useful drug for preventing these recurrences. […] The CORP trial, an independent non-sponsored study and the first multicentre double-blind randomised trial of colchicine in the secondary prevention of pericarditis, was performed in four centres in Italy and recruited 120 consecutive patients with a first episode of recurrent pericarditis. […] Colchicine was given as adjunctive therapy at an initial dose of 1.0-2.0 mg for the first day and a maintenance dose of 0.5-1.0 mg daily for the following six months.

• #2 Pericarditis prophylactic therapy after sinus node–sparing hybrid ablation for inappropriate sinus tachycardia/postural orthostatic sinus tachycardia

  https://pmc.ncbi.nlm.nih.gov/articles/PMC10964471/

  Pericarditis is the most common complication following hybrid sinus nodesparing ablation for inappropriate sinus tachycardia (IST)/postural orthostatic tachycardia syndrome (POTS). […] The study sought to evaluate the association of prophylaxis therapy on the risk of symptomatic pericarditis following hybrid IST/POTS ablation. […] Pharmacological prophylaxis therapy was based on acetylsalicylic acid and colchicine started on the day of the ablation and continued for at least 3 months. […] At survival analysis, prophylaxis was associated with higher rate of freedom from pericarditis (81.9% vs 47.2%, log-rank P .001). […] In a large cohort of patients undergoing hybrid ablation for IST/POTS, a prophylaxis therapy with acetylsalicylic acid and colchicine was associated with a lower rate of symptomatic pericarditis.

• #2 Pericarditis prophylactic therapy after sinus node–sparing hybrid ablation for inappropriate sinus tachycardia/postural orthostatic sinus tachycardia

  https://pmc.ncbi.nlm.nih.gov/articles/PMC10964471/

  After hybrid sinus nodesparing inappropriate sinus node tachycardia ablation, a symptomatic pericarditis can be diagnosed in 18.1% of patients receiving prophylaxis treatment vs 52.8% of patients not receiving prophylaxis treatment (73% risk reduction); […] Prophylaxis therapy was well tolerated, and none of the patients discontinued it prematurely. […] The administration of prophylaxis therapy was associated with a lower rate of symptomatic pericarditis from 52.8% to 18.1% and prophylaxis therapy was independently associated with a 73% risk reduction.

• #2 Pericarditis – Harvard Health

  https://www.health.harvard.edu/a_to_z/pericarditis-a-to-z

  Because pericarditis can be the result of so many very different illnesses, there are no routine guidelines to prevent the condition. You can help prevent pericarditis caused by infections by practicing good hygiene, especially washing your hands often, and by keeping up with recommended immunizations. […] To prevent pericarditis caused by heart attack, you can reduce your risk of coronary artery disease by not smoking, eating a healthy diet, exercising regularly, lowering LDL cholesterol and controlling blood pressure. […] To reduce your risk of trauma-related pericarditis, you should wear a seat belt whenever you drive and wear appropriate chest-protecting equipment when you play contact sports.

• #2 Pericarditis | Symptoms, Causes, Treatment & Preventionarrow-icon-size3

  https://www.modernheartandvascular.com/pericarditis/

  While there’s no foolproof way to prevent pericarditis completely, there are smart moves you can make to lower your odds of facing this heart hiccup. Think of it like putting up a strong defense against an unwelcome intruder: […] Fight Off Infections […] Vaccinations: Stay up-to-date on your shots. Vaccines against the flu, COVID-19, and other common bugs can help keep your immune system strong and ward off potential triggers for pericarditis. […] Hygiene habits: Wash your hands often, especially during cold and flu season. Avoid close contact with sick people. These simple steps can go a long way in preventing infections. […] Take Charge of Your Health with Pericarditis […] Manage underlying conditions: If you have an autoimmune disease or other chronic health issues, keep them in check. Follow your treatment plan and work closely with your doctor to stay on top of things.

• #2 Pericarditis: What Is It, Symptoms, Causes and Treatment | MedPark Hospital

  https://www.medparkhospital.com/en-US/disease-and-treatment/pericarditis

  How can you prevent pericarditis? […] Practice good hygiene by maintaining regular hand-washing habits, which can prevent the spread of infectious agents. […] Avoid people with viral or flu-like illnesses. […] Get the recommended vaccines, such as COVID-19, rubella, and influenza, which can prevent diseases causing myocarditis. While rare, the COVID-19 vaccine may lead to myocarditis, particularly among males aged 12 through 17. You can discuss the advantages and potential risks before vaccination with your doctor.

• #2 Pericarditis | Symptoms, Causes, Treatment & Preventionarrow-icon-size3

  https://www.modernheartandvascular.com/pericarditis/

  Healthy lifestyle: Eat a balanced diet, exercise regularly, and get enough sleep. A healthy body is better equipped to fight off infections and inflammation. […] Early Intervention is Key […] Don’t ignore symptoms: If you experience any unusual chest pain or discomfort, don’t brush it off. Seek medical attention promptly. Early diagnosis and treatment can make all the difference. […] Follow your treatment plan: If you’ve been diagnosed with pericarditis, it’s essential to stick to your treatment plan. This may include medications, rest, and lifestyle changes. Make sure to attend follow-up appointments with your doctor.

• #2 Acute Pericarditis: Causes, Symptoms and Treatment

  https://my.clevelandclinic.org/health/diseases/22918-acute-pericarditis

  Because acute pericarditis happens unpredictably, it isnt a preventable condition. The only thing you can do is reduce your risk of developing it by avoiding situations or circumstances that can cause it. […] The only way to avoid developing pericarditis is to avoid circumstances that can cause it. The ways you can do this include: […] Get bacterial infections treated. Untreated bacterial infections can deal severe damage to your body, especially your heart and nearby organs. If you suspect you have a bacterial infection, getting it diagnosed and treated quickly is extremely important. […] Avoid injuries. Using proper safety equipment, especially wearing your seatbelt while traveling in a car is a key way to avoid injuries to your chest that can lead to acute pericarditis. This also includes being cautious when working with tools or machinery that can cause serious injuries to your chest.

• #2 Pericarditis: Symptoms, Treatment, Causes

  https://www.healthline.com/health/pericarditis

  Theres no conclusive way to prevent pericarditis, especially viral pericarditis. […] But if you experience pericarditis, following your treatment plan, using colchicine, and avoiding corticosteroids may reduce the chance of it recurring. […] Until you fully recover, rest and avoid strenuous physical activity. Discuss with your doctor how long you should limit your activity. […] If you see any signs of recurrence, check with your doctor as soon as possible.

• #2 Pericarditis + 6 Natural Ways to Help Manage Recovery – Dr. Axe

  https://draxe.com/health/pericarditis/

  Prevention and Recovery […] 1. Rest and Reduce Stress […] Any type of bodily stress, including intense exercise and physical activity beyond walking and stretching, can be harmful during pericarditis. Its recommended that you take it easy while you heal, so be sure to get plenty of sleep every night (at least seven to nine hours) and to rest when needed. […] Exercise can be beneficial once you’ve healed enough since it benefits immune function, circulation and cardiovascular health. […] 2. Eat An Anti-Inflammatory Diet […] Support your immune system by cutting out processed foods from your diet and eating whole, nutrient-dense foods that provide antioxidants, vitamins and minerals. […] Here are steps you can take to reduce inflammation by eating a nutrient-dense diet: Eat plenty of raw fruits and vegetables. Include foods high in vitamin C and A like oranges, kale and other leafy greens, kiwi, strawberries, grapefruit, red peppers, green peppers, guava and broccoli. […] Avoid inflammatory foods that can worsen existing health conditions, including processed grains (especially those gaining gluten), conventional dairy products, foods with added sugar and synthetic ingredients, processed meats, fast food and fried foods.

• #2 Acute Pericarditis Treatment: Update on Colchicine

  https://www.uspharmacist.com/article/acute-pericarditis-treatment-update-on-colchicine

  Strong evidence has emerged for the use of colchicine to treat and prevent recurrent pericarditis. […] To prevent recurrence, NSAIDs and/or colchicine should be added toward the end of the taper. […] Colchicine may be useful in recurrent pericarditis, which is immune-mediated, owing to its ability to disrupt the inflammatory cycle involved in pathogenesis. […] Recent studies have provided strong evidence suggesting that colchicine is an effective treatment option for both acute and recurrent pericarditis. […] Pharmacists can play a vital role in ensuring the safe and effective treatment of acute and recurrent pericarditis.

• #2

  http://www.crd.york.ac.uk/CRDWeb/ShowRecord.asp?AccessionNumber=12012033317

  The authors concluded that the available evidence suggested that colchicine was safe and effective for the primary or secondary prevention of pericarditis. […] The authors stated that colchicine was safe and effective for the primary or secondary prevention of pericarditis, and should be the first-line therapy for prevention, but the dosage and potential contraindications should be carefully considered.

• #3 Pericarditis + 6 Natural Ways to Help Manage Recovery – Dr. Axe

  https://draxe.com/health/pericarditis/

  Prevention and Recovery […] 1. Rest and Reduce Stress […] Any type of bodily stress, including intense exercise and physical activity beyond walking and stretching, can be harmful during pericarditis. Its recommended that you take it easy while you heal, so be sure to get plenty of sleep every night (at least seven to nine hours) and to rest when needed. […] Exercise can be beneficial once you’ve healed enough since it benefits immune function, circulation and cardiovascular health. […] 2. Eat An Anti-Inflammatory Diet […] Support your immune system by cutting out processed foods from your diet and eating whole, nutrient-dense foods that provide antioxidants, vitamins and minerals. […] Here are steps you can take to reduce inflammation by eating a nutrient-dense diet: Eat plenty of raw fruits and vegetables. Include foods high in vitamin C and A like oranges, kale and other leafy greens, kiwi, strawberries, grapefruit, red peppers, green peppers, guava and broccoli. […] Avoid inflammatory foods that can worsen existing health conditions, including processed grains (especially those gaining gluten), conventional dairy products, foods with added sugar and synthetic ingredients, processed meats, fast food and fried foods.

• #3 Acute Pericarditis: Causes, Symptoms and Treatment

  https://my.clevelandclinic.org/health/diseases/22918-acute-pericarditis

  Follow your healthcare providers guidance. Seeing your healthcare provider as recommended and taking medications/treatments as prescribed can help you avoid having another occurrence of pericarditis or developing a chronic version of the condition. This is also true if you have a health condition that increases your risk of developing acute pericarditis.

Zobacz więcej