Materiały źródłowe

• #1 Lipoma – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK507906/

  Lipomas represent the most common mesenchymal tumors of the human body. About 1 in every thousand persons will have lipoma at some point in their lifetime. The precise cause of lipomas is unknown. A potential link between trauma and lipoma formation has been postulated, hypothesizing trauma induces cytokine release that then triggers preadipocyte differentiation and maturation. […] Genetics may play a role in a minority of patients, as 2% to 3% of affected patients have multiple lesions inherited in a familial pattern. An gene association has been described on chromosome 12 in some solitary lipomas; a mutation in the HMGA2-LPP fusion gene is present in some of these tumors. There also are several genetic syndromes that feature lipomas as a clinical manifestation. The incidence of lipomas is also increased in patients with obesity, hyperlipidemia, and diabetes mellitus.

• #2 Lipoma | Radiology Reference Article | Radiopaedia.org

  https://radiopaedia.org/articles/lipoma?lang=us

  Lipomas are benign tumors composed of mature adipocytes. They are the most common soft tissue tumor, seen in ~2% of the population. […] The etiology of lipomas is unknown. In 5-15% of patients, lipomas are multiple, and ~33% of these will be familial.

• #3 Lipoma | Beacon Health System

  https://www.beaconhealthsystem.org/library/diseases-and-conditions/lipoma/

  The cause of lipomas isn’t fully understood. They tend to run in families, so genetic factors likely play a role in their development. […] Lipomas tend to run in families.

• #4 Lipoma Pathology – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK482343/

  While the etiology of lipomas is unclear, some studies have shown a genetic link, whereby about two-thirds of lipomas demonstrate genetic abnormalities. […] In addition to the possibility of a genetic link, another theory presents the idea that there is a direct positive correlation between trauma to an area and lipoma production. Research shows a link between adipose tumor growth as a post-traumatic event following a direct impact on that area of soft tissue. […] In addition to the risk factors listed above, other possible connections that may lead to lipomas are obesity, alcohol abuse, liver disease, as well as glucose intolerance.

• #5 What Causes Lipomas?: Surgical Associates of North Texas: Advanced Laparoscopic Surgeons

  https://www.surgicalassociatesofnorthtexas.com/blog/what-causes-lipomas

  A lipoma is a type of tumor but dont let that scare you. […] The exact cause of these masses isnt known. However, the most significant risk of having lipomas involves a family history of the growths. […] Because genetics is the leading cause of lipomas, theres little you can do to keep from developing the condition.

• #6 Lipoma | Beacon Health System

  https://www.beaconhealthsystem.org/library/diseases-and-conditions/lipoma/

  The cause of lipomas isn’t fully understood. They tend to run in families, so genetic factors likely play a role in their development. […] Lipomas tend to run in families.

• #7 Lipoma Pathology – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK482343/

  While the etiology of lipomas is unclear, some studies have shown a genetic link, whereby about two-thirds of lipomas demonstrate genetic abnormalities. […] In addition to the possibility of a genetic link, another theory presents the idea that there is a direct positive correlation between trauma to an area and lipoma production. Research shows a link between adipose tumor growth as a post-traumatic event following a direct impact on that area of soft tissue. […] In addition to the risk factors listed above, other possible connections that may lead to lipomas are obesity, alcohol abuse, liver disease, as well as glucose intolerance.

• #8 Lipomas: Practice Essentials, Pathophysiology, Etiology

  https://emedicine.medscape.com/article/191233-overview

  Speculation exists regarding a potential link between trauma and subsequent lipoma formation. One theory suggests that trauma-related fat herniation through tissue planes creates so-called pseudolipomas. It has also been suggested that trauma-induced cytokine release triggers pre-adipocyte differentiation and maturation. To date, no definitive link between trauma and lipoma formation has been prospectively demonstrated. […] While the exact etiology of lipomas remains uncertain, an association with gene rearrangements of chromosome 12 has been established in cases of solitary lipomas, as has an abnormality in the HMGA2-LPP fusion gene.

• #9 Lipoma – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK507906/

  Lipomas represent the most common mesenchymal tumors of the human body. About 1 in every thousand persons will have lipoma at some point in their lifetime. The precise cause of lipomas is unknown. A potential link between trauma and lipoma formation has been postulated, hypothesizing trauma induces cytokine release that then triggers preadipocyte differentiation and maturation. […] Genetics may play a role in a minority of patients, as 2% to 3% of affected patients have multiple lesions inherited in a familial pattern. An gene association has been described on chromosome 12 in some solitary lipomas; a mutation in the HMGA2-LPP fusion gene is present in some of these tumors. There also are several genetic syndromes that feature lipomas as a clinical manifestation. The incidence of lipomas is also increased in patients with obesity, hyperlipidemia, and diabetes mellitus.

• #10 Lipoma – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK507906/

  Lipomas represent the most common mesenchymal tumors of the human body. About 1 in every thousand persons will have lipoma at some point in their lifetime. The precise cause of lipomas is unknown. A potential link between trauma and lipoma formation has been postulated, hypothesizing trauma induces cytokine release that then triggers preadipocyte differentiation and maturation. […] Genetics may play a role in a minority of patients, as 2% to 3% of affected patients have multiple lesions inherited in a familial pattern. An gene association has been described on chromosome 12 in some solitary lipomas; a mutation in the HMGA2-LPP fusion gene is present in some of these tumors. There also are several genetic syndromes that feature lipomas as a clinical manifestation. The incidence of lipomas is also increased in patients with obesity, hyperlipidemia, and diabetes mellitus.

• #11 Lipomas: Practice Essentials, Pathophysiology, Etiology

  https://emedicine.medscape.com/article/191233-overview

  Speculation exists regarding a potential link between trauma and subsequent lipoma formation. One theory suggests that trauma-related fat herniation through tissue planes creates so-called pseudolipomas. It has also been suggested that trauma-induced cytokine release triggers pre-adipocyte differentiation and maturation. To date, no definitive link between trauma and lipoma formation has been prospectively demonstrated. […] While the exact etiology of lipomas remains uncertain, an association with gene rearrangements of chromosome 12 has been established in cases of solitary lipomas, as has an abnormality in the HMGA2-LPP fusion gene.

• #12 Lipoma – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK507906/

  Lipomas represent the most common mesenchymal tumors of the human body. About 1 in every thousand persons will have lipoma at some point in their lifetime. The precise cause of lipomas is unknown. A potential link between trauma and lipoma formation has been postulated, hypothesizing trauma induces cytokine release that then triggers preadipocyte differentiation and maturation. […] Genetics may play a role in a minority of patients, as 2% to 3% of affected patients have multiple lesions inherited in a familial pattern. An gene association has been described on chromosome 12 in some solitary lipomas; a mutation in the HMGA2-LPP fusion gene is present in some of these tumors. There also are several genetic syndromes that feature lipomas as a clinical manifestation. The incidence of lipomas is also increased in patients with obesity, hyperlipidemia, and diabetes mellitus.

• #13 Lipoma | Healthgrades

  https://resources.healthgrades.com/right-care/symptoms-and-conditions/lipoma

  A lipoma is a benign lump or mass that is made up of fat cells (adipocytes). […] Lipomas may begin to grow after a tissue injury or trauma, and they tend to run in families. […] The reason why some people develop lipomas is not known, although family history appears to play a role. […] People who develop more than one lipoma may have an extremely rare inherited disorder called familial multiple lipomatosis. […] Lipomas can also grow in subcutaneous tissue that has been injured or traumatized. […] Certain factors and diseases are thought to increase your chances of developing a lipoma. […] Common risk factors for lipomas include: Family history of lipomas, Familial multiple lipomatosis (rare inherited condition involving the development of multiple benign lipomas), Previous soft tissue trauma.

• #14 Lipoma – Wikipedia

  https://en.wikipedia.org/wiki/Lipoma

  The cause is generally unclear. […] Risk factors include family history, obesity, and lack of exercise. […] The tendency to develop a lipoma is not necessarily hereditary, although hereditary conditions such as familial multiple lipomatosis might include lipoma development. […] Genetic studies in mice have shown a correlation between the HMG I-C gene (previously identified as a gene related to obesity) and lipoma development. […] Cases have been reported where minor injuries are alleged to have triggered the growth of a lipoma, called a „post-traumatic lipoma”. […] However, the link between trauma and the development of lipomas is controversial.

• #15 Lipoma: What Is It, Causes, Symptoms, Types, Treatment

  https://my.clevelandclinic.org/health/diseases/15008-lipomas

  Lipomas are benign soft tissue tumors. They grow slowly and are not cancerous. […] Healthcare providers arent sure what causes lipomas to grow. They are inherited (passed down through families). Youre more likely to develop a lipoma if someone in your family has one. […] Some conditions cause multiple lipomas to form on the body. Lipoma-causing conditions include: Dercums disease, Gardner syndrome, Hereditary multiple lipomatosis, Madelungs disease.

• #16 What Is Lipoma? Symptoms, Causes, Diagnosis, Treatment, and Prevention

  https://www.everydayhealth.com/lipoma/guide/

  Medical experts don’t know what causes a lipoma, but some think it’s a response to a physical trauma. […] Others think that the lipoma already exists and is brought to light because of the injury. […] Lipomas often run in families, so genes may play a role. […] Though lipomas can develop in anyone, they are most likely to appear in middle-aged adults between age 40 and 60. […] A person may develop one or more lipomas if they have Gardner syndrome (an inherited condition that causes benign and malignant tumors to form), adiposis dolorosa, familial multiple lipomatosis, or Madelung disease (seen mostly in men who are heavy drinkers). […] While lipomas are hardly ever cancerous, it’s important to get them checked out so that your doctor can make sure you don’t have liposarcoma. […] And while it’s extremely rare, lipomas can sometimes be associated with certain disorders such as multiple hereditary lipomatosis, Gardner syndrome, adiposis dolorosa, and Madelung disease.

• #17 Lipoma: What Is It, Causes, Symptoms, Types, Treatment

  https://my.clevelandclinic.org/health/diseases/15008-lipomas

  Lipomas are benign soft tissue tumors. They grow slowly and are not cancerous. […] Healthcare providers arent sure what causes lipomas to grow. They are inherited (passed down through families). Youre more likely to develop a lipoma if someone in your family has one. […] Some conditions cause multiple lipomas to form on the body. Lipoma-causing conditions include: Dercums disease, Gardner syndrome, Hereditary multiple lipomatosis, Madelungs disease.

• #18 Lipoma (Fatty Tumor)

  https://www.webmd.com/skin-problems-and-treatments/what-is-a-lipoma

  It isnt clear what causes them. However, researchers have noticed that […] They run in families. […] They often show up after an injury, though doctors dont know whether thats what makes them form. […] Lipoma may also occur as a symptom of some rare health conditions. These conditions include: […] Hereditary multiple lipomatosis: This condition causes painless lipomas to grow on the trunk, arms, and legs. It runs in families and is also called familial multiple lipomatosis.

• #19 What Is Lipoma? Symptoms, Causes, Diagnosis, Treatment, and Prevention

  https://www.everydayhealth.com/lipoma/guide/

  Medical experts don’t know what causes a lipoma, but some think it’s a response to a physical trauma. […] Others think that the lipoma already exists and is brought to light because of the injury. […] Lipomas often run in families, so genes may play a role. […] Though lipomas can develop in anyone, they are most likely to appear in middle-aged adults between age 40 and 60. […] A person may develop one or more lipomas if they have Gardner syndrome (an inherited condition that causes benign and malignant tumors to form), adiposis dolorosa, familial multiple lipomatosis, or Madelung disease (seen mostly in men who are heavy drinkers). […] While lipomas are hardly ever cancerous, it’s important to get them checked out so that your doctor can make sure you don’t have liposarcoma. […] And while it’s extremely rare, lipomas can sometimes be associated with certain disorders such as multiple hereditary lipomatosis, Gardner syndrome, adiposis dolorosa, and Madelung disease.

• #20 Lipoma: Symptoms, Causes, Diagnosis, and Treatment

  https://www.verywellhealth.com/lipoma-overview-4774640

  Gardner syndrome: A type of a rare condition known as familial adenomatous polyposis (FAP), where those affected develop polyps, tumors, and lipomas, among other signs and symptoms. Those with Gardner syndrome have a greater chance than others of developing FAP-related cancers, particularly in and around the colon. […] Madelungs disease: Also known as multiple symmetric lipomatosis, this rare condition is characterized by growths in the upper part of the body, such as the neck, arms, shoulders, and chest. It primarily affects middle-aged men of Mediterranean ancestry with a history of prolonged or substantial alcohol use. […] Adiposis dolorosa: A condition where the lipomas or folds of fatty tissue apply pressure to nerves and can be painful. Its especially common in women with obesity or overweight between the ages of 35 and 50. […] In addition to medical conditions and genetics, other risk factors can also increase a persons chances of lipomas, including age and sex. Lipomas are most likely to appear between the ages of 40 and 60, and theyre slightly more common in men than women.

• #21 Lipoma: What Is It, Causes, Symptoms, Types, Treatment

  https://my.clevelandclinic.org/health/diseases/15008-lipomas

  Lipomas are benign soft tissue tumors. They grow slowly and are not cancerous. […] Healthcare providers arent sure what causes lipomas to grow. They are inherited (passed down through families). Youre more likely to develop a lipoma if someone in your family has one. […] Some conditions cause multiple lipomas to form on the body. Lipoma-causing conditions include: Dercums disease, Gardner syndrome, Hereditary multiple lipomatosis, Madelungs disease.

• #22 Adiposis dolorosa: MedlinePlus GeneticsLock

  https://medlineplus.gov/genetics/condition/adiposis-dolorosa/

  Adiposis dolorosa is a condition characterized by painful folds of fatty (adipose) tissue or the growth of multiple noncancerous (benign) fatty tumors called lipomas. […] The cause of adiposis dolorosa is unknown. The condition is thought to have a genetic component because a few families with multiple affected family members have been reported. However, no associated genes have been identified. […] Several other possible causes of adiposis dolorosa have been suggested, although none have been confirmed. They include the use of medications called corticosteroids, dysfunction of the endocrine system (which produces hormones), or changes in the deposition and breakdown of fat (adipose tissue metabolism). […] Researchers have also suggested that adiposis dolorosa could be an autoimmune disorder, which occurs when the immune system malfunctions and attacks the body’s own tissues and organs. However, there is no firm evidence that the condition is related to abnormal inflammation or other immune system malfunction. […] It is unknown why adiposis dolorosa usually occurs in people who are overweight or have obesity, or why the signs and symptoms do not appear until mid-adulthood.

• #23 Lipoma: Causes, symptoms, and treatment

  https://www.medicalnewstoday.com/articles/322551

  A lipoma is a lump under the skin that occurs due to an overgrowth of fat cells. […] Experts do not fully understand what causes a lipoma. […] Some people inherit a faulty gene from their parents that can cause one or more lipomas. This is rare and is known as familial multiple lipomatosis. […] Researchers associate lipomas with some medical conditions, including: Gardners syndrome, Cowden syndrome, Madelungs disease, adiposis dolorosa. […] Some lipomas may also result from an injury that involves a substantial impact on the area.

• #24 Causes of Lipomas | Alan Woodward Surgical Group

  https://awsg.co.uk/news/causes-of-lipomas/

  Lipomas can occur anywhere on the body, but are mostly found on the neck, shoulders, arms, and back. While the exact cause of lipomas isn’t fully understood, certain factors are known to contribute to their development. […] Lipomas tend to occur more frequently in people with specific medical conditions. […] Gardner’s Syndrome – This is a genetic disorder that causes growths in different areas of the body, including lipomas. […] Cowden Syndrome – Another genetic disorder, Cowden syndrome, is characterised by multiple noncancerous, tumour-like growths. Lipomas are a common occurrence in those who have this condition. […] Madelung’s Disease – This rare disorder involves the growth of multiple lipomas around the neck and shoulders. It primarily affects middle-aged men, especially those with a history of alcohol abuse.

• #25 Lipoma: What Is It, Causes, Symptoms, Types, Treatment

  https://my.clevelandclinic.org/health/diseases/15008-lipomas

  Lipomas are benign soft tissue tumors. They grow slowly and are not cancerous. […] Healthcare providers arent sure what causes lipomas to grow. They are inherited (passed down through families). Youre more likely to develop a lipoma if someone in your family has one. […] Some conditions cause multiple lipomas to form on the body. Lipoma-causing conditions include: Dercums disease, Gardner syndrome, Hereditary multiple lipomatosis, Madelungs disease.

• #26 Lipoma: Symptoms, Causes, Diagnosis, and Treatment

  https://www.verywellhealth.com/lipoma-overview-4774640

  Gardner syndrome: A type of a rare condition known as familial adenomatous polyposis (FAP), where those affected develop polyps, tumors, and lipomas, among other signs and symptoms. Those with Gardner syndrome have a greater chance than others of developing FAP-related cancers, particularly in and around the colon. […] Madelungs disease: Also known as multiple symmetric lipomatosis, this rare condition is characterized by growths in the upper part of the body, such as the neck, arms, shoulders, and chest. It primarily affects middle-aged men of Mediterranean ancestry with a history of prolonged or substantial alcohol use. […] Adiposis dolorosa: A condition where the lipomas or folds of fatty tissue apply pressure to nerves and can be painful. Its especially common in women with obesity or overweight between the ages of 35 and 50. […] In addition to medical conditions and genetics, other risk factors can also increase a persons chances of lipomas, including age and sex. Lipomas are most likely to appear between the ages of 40 and 60, and theyre slightly more common in men than women.

• #27 Lipomas: Practice Essentials, Pathophysiology, Etiology

  https://emedicine.medscape.com/article/191233-overview

  Speculation exists regarding a potential link between trauma and subsequent lipoma formation. One theory suggests that trauma-related fat herniation through tissue planes creates so-called pseudolipomas. It has also been suggested that trauma-induced cytokine release triggers pre-adipocyte differentiation and maturation. To date, no definitive link between trauma and lipoma formation has been prospectively demonstrated. […] While the exact etiology of lipomas remains uncertain, an association with gene rearrangements of chromosome 12 has been established in cases of solitary lipomas, as has an abnormality in the HMGA2-LPP fusion gene.

• #28 Lipoma | 5-Minute Clinical Consult

  https://www.unboundmedicine.com/5minute/view/5-Minute-Clinical-Consult/116841/all/Lipoma

  The etiology and pathogenesis of lipomas is unclear. […] A pathogenetic link between soft tissue trauma and the formation of lipomas has been suggested. […] Two potential explanations to correlate soft tissue trauma and adipose tissue tumor growth have been proposed: Formation of so-called posttraumatic pseudolipomas by prolapsing adipose tissue through fascia resulting from direct impact […] Lipoma formation as a result of preadipocyte differentiation and proliferation mediated by cytokine release following soft tissue trauma and hematoma formation. […] Because the pathogenesis of lipomas is unclear, risk factors are difficult to qualify. […] Possible risk factors include obesity, alcohol abuse, liver disease, glucose intolerance, and soft tissue trauma.

• #29 Lipomas: Practice Essentials, Pathophysiology, Etiology

  https://emedicine.medscape.com/article/191233-overview

  Speculation exists regarding a potential link between trauma and subsequent lipoma formation. One theory suggests that trauma-related fat herniation through tissue planes creates so-called pseudolipomas. It has also been suggested that trauma-induced cytokine release triggers pre-adipocyte differentiation and maturation. To date, no definitive link between trauma and lipoma formation has been prospectively demonstrated. […] While the exact etiology of lipomas remains uncertain, an association with gene rearrangements of chromosome 12 has been established in cases of solitary lipomas, as has an abnormality in the HMGA2-LPP fusion gene.

• #30 Lipoma | 5-Minute Clinical Consult

  https://www.unboundmedicine.com/5minute/view/5-Minute-Clinical-Consult/116841/all/Lipoma

  The etiology and pathogenesis of lipomas is unclear. […] A pathogenetic link between soft tissue trauma and the formation of lipomas has been suggested. […] Two potential explanations to correlate soft tissue trauma and adipose tissue tumor growth have been proposed: Formation of so-called posttraumatic pseudolipomas by prolapsing adipose tissue through fascia resulting from direct impact […] Lipoma formation as a result of preadipocyte differentiation and proliferation mediated by cytokine release following soft tissue trauma and hematoma formation. […] Because the pathogenesis of lipomas is unclear, risk factors are difficult to qualify. […] Possible risk factors include obesity, alcohol abuse, liver disease, glucose intolerance, and soft tissue trauma.

• #31 Lipomas: Practice Essentials, Pathophysiology, Etiology

  https://emedicine.medscape.com/article/191233-overview

  Speculation exists regarding a potential link between trauma and subsequent lipoma formation. One theory suggests that trauma-related fat herniation through tissue planes creates so-called pseudolipomas. It has also been suggested that trauma-induced cytokine release triggers pre-adipocyte differentiation and maturation. To date, no definitive link between trauma and lipoma formation has been prospectively demonstrated. […] While the exact etiology of lipomas remains uncertain, an association with gene rearrangements of chromosome 12 has been established in cases of solitary lipomas, as has an abnormality in the HMGA2-LPP fusion gene.

• #32 Lipoma – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK507906/

  Lipomas represent the most common mesenchymal tumors of the human body. About 1 in every thousand persons will have lipoma at some point in their lifetime. The precise cause of lipomas is unknown. A potential link between trauma and lipoma formation has been postulated, hypothesizing trauma induces cytokine release that then triggers preadipocyte differentiation and maturation. […] Genetics may play a role in a minority of patients, as 2% to 3% of affected patients have multiple lesions inherited in a familial pattern. An gene association has been described on chromosome 12 in some solitary lipomas; a mutation in the HMGA2-LPP fusion gene is present in some of these tumors. There also are several genetic syndromes that feature lipomas as a clinical manifestation. The incidence of lipomas is also increased in patients with obesity, hyperlipidemia, and diabetes mellitus.

• #33 Lipoma (fatty lumps)

  https://dermnetnz.org/topics/lipoma

  While lipomas typically affect patients between 40 and 60 years of age, they can occur at any age and are more common in patients with hyperlipidaemia, type 2 diabetes mellitus, and obesity. […] The cause of lipomas is unknown. One hypothesis posits that they occur at sites of trauma as a result of the release of cytokines which cause preadipocyte differentiation and maturation.

• #34 Lipoma – Wikipedia

  https://en.wikipedia.org/wiki/Lipoma

  The cause is generally unclear. […] Risk factors include family history, obesity, and lack of exercise. […] The tendency to develop a lipoma is not necessarily hereditary, although hereditary conditions such as familial multiple lipomatosis might include lipoma development. […] Genetic studies in mice have shown a correlation between the HMG I-C gene (previously identified as a gene related to obesity) and lipoma development. […] Cases have been reported where minor injuries are alleged to have triggered the growth of a lipoma, called a „post-traumatic lipoma”. […] However, the link between trauma and the development of lipomas is controversial.

• #35 Lipoma: Causes, symptoms, and treatment

  https://www.medicalnewstoday.com/articles/322551

  A lipoma is a lump under the skin that occurs due to an overgrowth of fat cells. […] Experts do not fully understand what causes a lipoma. […] Some people inherit a faulty gene from their parents that can cause one or more lipomas. This is rare and is known as familial multiple lipomatosis. […] Researchers associate lipomas with some medical conditions, including: Gardners syndrome, Cowden syndrome, Madelungs disease, adiposis dolorosa. […] Some lipomas may also result from an injury that involves a substantial impact on the area.

• #36 Lipoma – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK507906/

  Lipomas represent the most common mesenchymal tumors of the human body. About 1 in every thousand persons will have lipoma at some point in their lifetime. The precise cause of lipomas is unknown. A potential link between trauma and lipoma formation has been postulated, hypothesizing trauma induces cytokine release that then triggers preadipocyte differentiation and maturation. […] Genetics may play a role in a minority of patients, as 2% to 3% of affected patients have multiple lesions inherited in a familial pattern. An gene association has been described on chromosome 12 in some solitary lipomas; a mutation in the HMGA2-LPP fusion gene is present in some of these tumors. There also are several genetic syndromes that feature lipomas as a clinical manifestation. The incidence of lipomas is also increased in patients with obesity, hyperlipidemia, and diabetes mellitus.

• #37 Lipoma | 5-Minute Clinical Consult

  https://www.unboundmedicine.com/5minute/view/5-Minute-Clinical-Consult/116841/all/Lipoma

  The etiology and pathogenesis of lipomas is unclear. […] A pathogenetic link between soft tissue trauma and the formation of lipomas has been suggested. […] Two potential explanations to correlate soft tissue trauma and adipose tissue tumor growth have been proposed: Formation of so-called posttraumatic pseudolipomas by prolapsing adipose tissue through fascia resulting from direct impact […] Lipoma formation as a result of preadipocyte differentiation and proliferation mediated by cytokine release following soft tissue trauma and hematoma formation. […] Because the pathogenesis of lipomas is unclear, risk factors are difficult to qualify. […] Possible risk factors include obesity, alcohol abuse, liver disease, glucose intolerance, and soft tissue trauma.

• #38 Lipoma Pathology – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK482343/

  While the etiology of lipomas is unclear, some studies have shown a genetic link, whereby about two-thirds of lipomas demonstrate genetic abnormalities. […] In addition to the possibility of a genetic link, another theory presents the idea that there is a direct positive correlation between trauma to an area and lipoma production. Research shows a link between adipose tumor growth as a post-traumatic event following a direct impact on that area of soft tissue. […] In addition to the risk factors listed above, other possible connections that may lead to lipomas are obesity, alcohol abuse, liver disease, as well as glucose intolerance.

• #39 Lipoma – Wikipedia

  https://en.wikipedia.org/wiki/Lipoma

  The cause is generally unclear. […] Risk factors include family history, obesity, and lack of exercise. […] The tendency to develop a lipoma is not necessarily hereditary, although hereditary conditions such as familial multiple lipomatosis might include lipoma development. […] Genetic studies in mice have shown a correlation between the HMG I-C gene (previously identified as a gene related to obesity) and lipoma development. […] Cases have been reported where minor injuries are alleged to have triggered the growth of a lipoma, called a „post-traumatic lipoma”. […] However, the link between trauma and the development of lipomas is controversial.

• #40 Lipoma – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK507906/

  Lipomas represent the most common mesenchymal tumors of the human body. About 1 in every thousand persons will have lipoma at some point in their lifetime. The precise cause of lipomas is unknown. A potential link between trauma and lipoma formation has been postulated, hypothesizing trauma induces cytokine release that then triggers preadipocyte differentiation and maturation. […] Genetics may play a role in a minority of patients, as 2% to 3% of affected patients have multiple lesions inherited in a familial pattern. An gene association has been described on chromosome 12 in some solitary lipomas; a mutation in the HMGA2-LPP fusion gene is present in some of these tumors. There also are several genetic syndromes that feature lipomas as a clinical manifestation. The incidence of lipomas is also increased in patients with obesity, hyperlipidemia, and diabetes mellitus.

• #41 Lipoma (fatty lumps)

  https://dermnetnz.org/topics/lipoma

  While lipomas typically affect patients between 40 and 60 years of age, they can occur at any age and are more common in patients with hyperlipidaemia, type 2 diabetes mellitus, and obesity. […] The cause of lipomas is unknown. One hypothesis posits that they occur at sites of trauma as a result of the release of cytokines which cause preadipocyte differentiation and maturation.

• #42 Lipoma – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK507906/

  Lipomas represent the most common mesenchymal tumors of the human body. About 1 in every thousand persons will have lipoma at some point in their lifetime. The precise cause of lipomas is unknown. A potential link between trauma and lipoma formation has been postulated, hypothesizing trauma induces cytokine release that then triggers preadipocyte differentiation and maturation. […] Genetics may play a role in a minority of patients, as 2% to 3% of affected patients have multiple lesions inherited in a familial pattern. An gene association has been described on chromosome 12 in some solitary lipomas; a mutation in the HMGA2-LPP fusion gene is present in some of these tumors. There also are several genetic syndromes that feature lipomas as a clinical manifestation. The incidence of lipomas is also increased in patients with obesity, hyperlipidemia, and diabetes mellitus.

• #43 Lipoma (fatty lumps)

  https://dermnetnz.org/topics/lipoma

  While lipomas typically affect patients between 40 and 60 years of age, they can occur at any age and are more common in patients with hyperlipidaemia, type 2 diabetes mellitus, and obesity. […] The cause of lipomas is unknown. One hypothesis posits that they occur at sites of trauma as a result of the release of cytokines which cause preadipocyte differentiation and maturation.

• #44 Lipoma Pathology – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK482343/

  While the etiology of lipomas is unclear, some studies have shown a genetic link, whereby about two-thirds of lipomas demonstrate genetic abnormalities. […] In addition to the possibility of a genetic link, another theory presents the idea that there is a direct positive correlation between trauma to an area and lipoma production. Research shows a link between adipose tumor growth as a post-traumatic event following a direct impact on that area of soft tissue. […] In addition to the risk factors listed above, other possible connections that may lead to lipomas are obesity, alcohol abuse, liver disease, as well as glucose intolerance.

• #45 Lipoma | 5-Minute Clinical Consult

  https://www.unboundmedicine.com/5minute/view/5-Minute-Clinical-Consult/116841/all/Lipoma

  The etiology and pathogenesis of lipomas is unclear. […] A pathogenetic link between soft tissue trauma and the formation of lipomas has been suggested. […] Two potential explanations to correlate soft tissue trauma and adipose tissue tumor growth have been proposed: Formation of so-called posttraumatic pseudolipomas by prolapsing adipose tissue through fascia resulting from direct impact […] Lipoma formation as a result of preadipocyte differentiation and proliferation mediated by cytokine release following soft tissue trauma and hematoma formation. […] Because the pathogenesis of lipomas is unclear, risk factors are difficult to qualify. […] Possible risk factors include obesity, alcohol abuse, liver disease, glucose intolerance, and soft tissue trauma.

• #46 Lipoma Pathology – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK482343/

  While the etiology of lipomas is unclear, some studies have shown a genetic link, whereby about two-thirds of lipomas demonstrate genetic abnormalities. […] In addition to the possibility of a genetic link, another theory presents the idea that there is a direct positive correlation between trauma to an area and lipoma production. Research shows a link between adipose tumor growth as a post-traumatic event following a direct impact on that area of soft tissue. […] In addition to the risk factors listed above, other possible connections that may lead to lipomas are obesity, alcohol abuse, liver disease, as well as glucose intolerance.

• #47 Lipoma | 5-Minute Clinical Consult

  https://www.unboundmedicine.com/5minute/view/5-Minute-Clinical-Consult/116841/all/Lipoma

  The etiology and pathogenesis of lipomas is unclear. […] A pathogenetic link between soft tissue trauma and the formation of lipomas has been suggested. […] Two potential explanations to correlate soft tissue trauma and adipose tissue tumor growth have been proposed: Formation of so-called posttraumatic pseudolipomas by prolapsing adipose tissue through fascia resulting from direct impact […] Lipoma formation as a result of preadipocyte differentiation and proliferation mediated by cytokine release following soft tissue trauma and hematoma formation. […] Because the pathogenesis of lipomas is unclear, risk factors are difficult to qualify. […] Possible risk factors include obesity, alcohol abuse, liver disease, glucose intolerance, and soft tissue trauma.

• #48 Lipoma: Symptoms, Causes, Diagnosis, and Treatment

  https://www.verywellhealth.com/lipoma-overview-4774640

  Gardner syndrome: A type of a rare condition known as familial adenomatous polyposis (FAP), where those affected develop polyps, tumors, and lipomas, among other signs and symptoms. Those with Gardner syndrome have a greater chance than others of developing FAP-related cancers, particularly in and around the colon. […] Madelungs disease: Also known as multiple symmetric lipomatosis, this rare condition is characterized by growths in the upper part of the body, such as the neck, arms, shoulders, and chest. It primarily affects middle-aged men of Mediterranean ancestry with a history of prolonged or substantial alcohol use. […] Adiposis dolorosa: A condition where the lipomas or folds of fatty tissue apply pressure to nerves and can be painful. Its especially common in women with obesity or overweight between the ages of 35 and 50. […] In addition to medical conditions and genetics, other risk factors can also increase a persons chances of lipomas, including age and sex. Lipomas are most likely to appear between the ages of 40 and 60, and theyre slightly more common in men than women.

• #49 Abdominal lipoma, what it is, causes and treatments

  https://www.operarme.com/blog/abdominal-lipoma-what-it-is-causes-and-treatments/

  Blows or injuries: Sometimes, a blow or injury can lead to the growth of a lipoma. The most common cases are on the thighs and legs, although they do not occur very often. […] Alcohol consumption: drinking alcohol may also increase a person’s risk of developing lipomatosis. […] Medical conditions: liver disease or difficulty controlling blood sugar can increase the risk of abdominal lipoma.

• #50 Lipoma: Symptoms, Causes, Stages, Diagnosis and Treatment – OncoDaily

  https://oncodaily.com/oncolibrary/cancer-types/lipoma

  Certain lifestyle factors have also been associated with an increased risk. Obesity may contribute due to excess fat tissue, while hyperlipidemia elevated blood lipid levels suggests a potential link between lipid metabolism and lipoma growth. Additionally, individuals with diabetes mellitus appear to have a higher prevalence of lipomas, hinting at a possible connection with glucose metabolism.

• #51 Lipoma (fatty lumps)

  https://dermnetnz.org/topics/lipoma

  While lipomas typically affect patients between 40 and 60 years of age, they can occur at any age and are more common in patients with hyperlipidaemia, type 2 diabetes mellitus, and obesity. […] The cause of lipomas is unknown. One hypothesis posits that they occur at sites of trauma as a result of the release of cytokines which cause preadipocyte differentiation and maturation.

• #52 What is a Lipoma? Symptoms, Causes and Risk Factors Los Angeles CA

  http://www.lipomacenterlosangeles.com/about-lipomas/

  Lipomas are benign growths, but there are still many reasons a patient may seek lipoma treatment or removal. […] The cause of lipomas is unknown. Roughly 1 in every 1,000 people will develop a lipoma, though some people are more likely to develop them than others. […] Risk factors for developing a lipoma include: Gender: women are slightly more likely to develop lipomas than men. […] If a family member has one or more lipomas, it increases the risk. […] While lipomas can appear at any age, they are more common in middle-aged people between the ages of 40 and 60. […] Rarely, lipomas are associated with multiple hereditary lipomatosis, adiposis dolorosa, Cowden syndrome, Madelung disease and Gardner’s syndrome. […] Recurring or multiple lipomas are not dangerous. They have the same characteristics of any other lipoma—they are completely benign growths consisting mainly of fat.

• #53 What Is Lipoma? Symptoms, Causes, Diagnosis, Treatment, and Prevention

  https://www.everydayhealth.com/lipoma/guide/

  Medical experts don’t know what causes a lipoma, but some think it’s a response to a physical trauma. […] Others think that the lipoma already exists and is brought to light because of the injury. […] Lipomas often run in families, so genes may play a role. […] Though lipomas can develop in anyone, they are most likely to appear in middle-aged adults between age 40 and 60. […] A person may develop one or more lipomas if they have Gardner syndrome (an inherited condition that causes benign and malignant tumors to form), adiposis dolorosa, familial multiple lipomatosis, or Madelung disease (seen mostly in men who are heavy drinkers). […] While lipomas are hardly ever cancerous, it’s important to get them checked out so that your doctor can make sure you don’t have liposarcoma. […] And while it’s extremely rare, lipomas can sometimes be associated with certain disorders such as multiple hereditary lipomatosis, Gardner syndrome, adiposis dolorosa, and Madelung disease.

• #54 Lipoma – treatment, symptoms and diagnosis | healthdirect

  https://www.healthdirect.gov.au/lipoma

  Lipomas are benign (not cancerous), fatty lumps that are quite common. […] The cause of lipomas is often unknown, but some families have a genetic tendency to develop them. […] The cause of lipomas is often unknown, but some families have a genetic tendency to develop them. They are more common in people aged 40 to 60 years. […] Other possible causes of lipoma include: diabetes, obesity, physical trauma, radiation, treatment with insulin injections and corticosteroids.

• #55 What is a Lipoma? Symptoms, Causes and Risk Factors Los Angeles CA

  http://www.lipomacenterlosangeles.com/about-lipomas/

  Lipomas are benign growths, but there are still many reasons a patient may seek lipoma treatment or removal. […] The cause of lipomas is unknown. Roughly 1 in every 1,000 people will develop a lipoma, though some people are more likely to develop them than others. […] Risk factors for developing a lipoma include: Gender: women are slightly more likely to develop lipomas than men. […] If a family member has one or more lipomas, it increases the risk. […] While lipomas can appear at any age, they are more common in middle-aged people between the ages of 40 and 60. […] Rarely, lipomas are associated with multiple hereditary lipomatosis, adiposis dolorosa, Cowden syndrome, Madelung disease and Gardner’s syndrome. […] Recurring or multiple lipomas are not dangerous. They have the same characteristics of any other lipoma—they are completely benign growths consisting mainly of fat.

• #56 Abdominal lipoma, what it is, causes and treatments

  https://www.operarme.com/blog/abdominal-lipoma-what-it-is-causes-and-treatments/

  Abdominal lipomas are a frequent reason for medical consultation, so if you are reading this article, it is likely that you have developed one of these nodules known as a lipoma. […] Some of the factors that may be influencing the development of lipomas include obesity, alcohol consumption, injuries, etc. […] Although the exact causes of abdominal lipomas are unknown, there are some risk factors that may influence their development. […] Hereditary factors: although a lipoma is not hereditary in origin, it is true that lipomatosis does have a high hereditary component. […] Obesity: these fatty lumps may be related to the patient’s weight gain, although there are no conclusive studies to confirm this. […] Gender: women are more likely to suffer from abdominal lipoma because they tend to accumulate fat in different parts of the body such as the thighs, breasts or abdomen. Lipomatosis, on the other hand, tends to be more common in men.

• #57 Lipomas: Symptoms, Causes and an FNA Diagnosis – Dr. Nadelman

  https://drnadelman.com/blog/lipomas-symptoms-causes-and-an-fna-diagnosis/

  A lipoma is one of those superficial lumps, like in the breast, that can cause a scare but actually turns out to be harmless. […] Scientists dont know what causes lipomas. […] Although lipomas can occur at any age, they are most likely to occur in older adults between the ages of 40 and 60. […] When lipomas occur in a womans breasts, it is usually after menopause. […] However, if the lipoma is large or rapidly growing, especially in the thigh, the possibility of it being a cancer is higher.

• #58 Lipoma: Symptoms, Causes, Stages, Diagnosis and Treatment – OncoDaily

  https://oncodaily.com/oncolibrary/cancer-types/lipoma

  While the exact cause of lipomas remains uncertain, several risk factors have been identified that may contribute to their development. […] One major factor is genetics. Familial Multiple Lipomatosis (FML) is a hereditary condition characterized by multiple lipomas, often appearing in early adulthood. It follows an autosomal dominant inheritance pattern, meaning there is a 50% chance of passing it to offspring if one parent is affected. Gene mutations regulating fat cell production are believed to play a role. Additionally, certain genetic syndromes like Dercums disease and Madelungs disease increase the likelihood of developing lipomas, suggesting a genetic predisposition. […] Another possible factor is trauma, though this remains controversial. Some researchers propose that injuries could trigger lipoma formation, a concept known as post-traumatic lipoma, but more studies are needed to confirm this link. Hormonal imbalances may also contribute. Since lipomas are more common in women, researchers suspect estrogen and progesterone fluctuations might influence their development. However, there is limited evidence to confirm a direct connection between hormones and lipoma formation.

• #59 Adiposis dolorosa: MedlinePlus GeneticsLock

  https://medlineplus.gov/genetics/condition/adiposis-dolorosa/

  Adiposis dolorosa is a condition characterized by painful folds of fatty (adipose) tissue or the growth of multiple noncancerous (benign) fatty tumors called lipomas. […] The cause of adiposis dolorosa is unknown. The condition is thought to have a genetic component because a few families with multiple affected family members have been reported. However, no associated genes have been identified. […] Several other possible causes of adiposis dolorosa have been suggested, although none have been confirmed. They include the use of medications called corticosteroids, dysfunction of the endocrine system (which produces hormones), or changes in the deposition and breakdown of fat (adipose tissue metabolism). […] Researchers have also suggested that adiposis dolorosa could be an autoimmune disorder, which occurs when the immune system malfunctions and attacks the body’s own tissues and organs. However, there is no firm evidence that the condition is related to abnormal inflammation or other immune system malfunction. […] It is unknown why adiposis dolorosa usually occurs in people who are overweight or have obesity, or why the signs and symptoms do not appear until mid-adulthood.

• #60 Adiposis dolorosa: MedlinePlus GeneticsLock

  https://medlineplus.gov/genetics/condition/adiposis-dolorosa/

  Adiposis dolorosa is a condition characterized by painful folds of fatty (adipose) tissue or the growth of multiple noncancerous (benign) fatty tumors called lipomas. […] The cause of adiposis dolorosa is unknown. The condition is thought to have a genetic component because a few families with multiple affected family members have been reported. However, no associated genes have been identified. […] Several other possible causes of adiposis dolorosa have been suggested, although none have been confirmed. They include the use of medications called corticosteroids, dysfunction of the endocrine system (which produces hormones), or changes in the deposition and breakdown of fat (adipose tissue metabolism). […] Researchers have also suggested that adiposis dolorosa could be an autoimmune disorder, which occurs when the immune system malfunctions and attacks the body’s own tissues and organs. However, there is no firm evidence that the condition is related to abnormal inflammation or other immune system malfunction. […] It is unknown why adiposis dolorosa usually occurs in people who are overweight or have obesity, or why the signs and symptoms do not appear until mid-adulthood.

• #61 Forehead Lipoma Removal: Causes & Expert Treatment

  https://citydermatologyclinic.com/lipomas/lipoma-on-forehead-causes-symptoms-and-treatment/

  While direct causation remains debated among medical researchers, some evidence suggests that blunt trauma to the forehead region may occasionally trigger lipoma development. […] However, it’s important to note that most forehead lipomas develop without any identifiable preceding injury. […] Other factors that have been investigated but show less conclusive connections include: metabolic disorders affecting fat storage, hormonal imbalances (particularly thyroid dysfunction), and obesity (which may make existing lipomas more noticeable but doesn’t directly cause them).

• #62 Adiposis dolorosa: MedlinePlus GeneticsLock

  https://medlineplus.gov/genetics/condition/adiposis-dolorosa/

  Adiposis dolorosa is a condition characterized by painful folds of fatty (adipose) tissue or the growth of multiple noncancerous (benign) fatty tumors called lipomas. […] The cause of adiposis dolorosa is unknown. The condition is thought to have a genetic component because a few families with multiple affected family members have been reported. However, no associated genes have been identified. […] Several other possible causes of adiposis dolorosa have been suggested, although none have been confirmed. They include the use of medications called corticosteroids, dysfunction of the endocrine system (which produces hormones), or changes in the deposition and breakdown of fat (adipose tissue metabolism). […] Researchers have also suggested that adiposis dolorosa could be an autoimmune disorder, which occurs when the immune system malfunctions and attacks the body’s own tissues and organs. However, there is no firm evidence that the condition is related to abnormal inflammation or other immune system malfunction. […] It is unknown why adiposis dolorosa usually occurs in people who are overweight or have obesity, or why the signs and symptoms do not appear until mid-adulthood.

• #63 Why is the Incidence of Lipoma Increasing? Analyzing the Trends

  https://mykarehealth.com/kareline/increasing-lipoma-cases

  There has been a notable increase in lipoma cases in recent years. […] Is it because of the improved detection methods? Or is there any other underlying reason behind this? […] Dietary modifications, such as consuming more processed foods, high-fat meals, and sugary drinks, may result in weight gain and increase the possibility of lipomas developing. […] An individual may be more likely to acquire the condition if they have a family history of lipomas. […] Environmental pollutants and toxins that are found in the environment, such as some substances in the food, water, and air, can cause certain abnormal metabolic processes. […] Prolonged exposure to radiation is another cause of increased lipoma. […] Middle aged adults, aged 40 to 60 years, are more likely to have lipomas, which indicates that aging plays a role.

• #64 Lipoma and Atypical Lipomatous Tumors – OrthoInfo – AAOS

  https://orthoinfo.aaos.org/en/diseases–conditions/lipoma

  A lipoma is a benign (noncancerous) tumor made up of fat tissue. It is the most common soft tissue tumor found in adults. […] The cause of lipomas is not completely understood. Some subtypes (conventional lipomas, spindle cell lipomas, pleomorphic lipomas) appear to have a genetic cause and may be inherited from family members. […] There has been no proven connection between the development of lipomas and any particular occupation or exposure to chemicals or radiation. Some doctors think that lipomas occur more often in inactive people. […] There is ongoing research to learn more about the various subtypes of lipomas and why they form in the first place.

• #65 Lipoma Causes and Treatment: A Comprehensive Guide – Cosmo aid

  https://cosmoaid.com/lipoma-causes-and-treatment/

  Lipoma, a relatively uncommon condition, refers to the development of benign fatty tumors called adipose tumors. […] Research suggests that genetic predisposition may play a significant role in the development of lipoma. Individuals with a family history of adipose tumor are more likely to develop them themselves. Specific genetic mutations may also contribute to the formation of these benign tumors. […] Certain environmental factors, such as obesity and high cholesterol levels, have been linked to an increased risk of developing lipoma. Additionally, trauma or injury to the affected area may trigger the growth of adipose tumor in some cases. […] Ongoing research into the causes and mechanisms of adipose tumor formation aims to identify new treatment targets and improve existing therapeutic approaches. […] Genetic and environmental factors can contribute to the development of adipose tumors, and various treatment modalities are available depending on the severity and symptoms of the condition.

• #66 Lipoma and Atypical Lipomatous Tumors – OrthoInfo – AAOS

  https://orthoinfo.aaos.org/en/diseases–conditions/lipoma

  A lipoma is a benign (noncancerous) tumor made up of fat tissue. It is the most common soft tissue tumor found in adults. […] The cause of lipomas is not completely understood. Some subtypes (conventional lipomas, spindle cell lipomas, pleomorphic lipomas) appear to have a genetic cause and may be inherited from family members. […] There has been no proven connection between the development of lipomas and any particular occupation or exposure to chemicals or radiation. Some doctors think that lipomas occur more often in inactive people. […] There is ongoing research to learn more about the various subtypes of lipomas and why they form in the first place.

• #67 Intramuscular Lipoma: Symptoms, Causes & Treatment

  https://my.clevelandclinic.org/health/diseases/23907-intramuscular-lipoma

  An intramuscular lipoma is a rare, noncancerous (benign) tumor. […] Experts arent sure why some people develop intramuscular lipomas. Potential causes include: Chronic irritation. Developmental disorders. Endocrine system disorders. Genetic disorders (gene mutations). Metabolic syndrome. Obesity. Traumatic accidents or injuries. […] Intramuscular lipomas are rare and occur for unknown reasons. There isnt any way to prevent them.

• #68 Brain Lipoma: Causes, Symptoms, and Treatments

  https://kamranaghayev.com/brain-lipoma/

  A lipoma in the brain is a slow-growing, benign tumor made up of adipose tissue. These tumors are congenital, meaning theyre present at birth, although they often remain undetected until later in life. […] The origin of these tumors is found in the adipose tissue, which is composed of fat cells. This tissue plays many essential roles in the body, including energy storage and insulation. […] The development, or pathogenesis, of a brain lipoma is thought to occur early in embryonic development, specifically during the formation of the meninx primitiva, an early form of the brains protective membranes. It is during this time that a section of meninx primitiva may mistakenly develop into adipose tissue, resulting in a lipoma. […] Brain lipomas have distinct features on imaging that usually make them distinguishable from other brain tumors.

• #69 Lipoma: Causes, Symptoms, Diagnosis, And Treatment

  https://medrechospital.com/blog/lipoma-causes-symptoms-diagnosis-and-treatment

  The exact causes of lipomas remain enigmatic, and while there isn’t a definitive explanation for their development, several factors have been linked to their occurrence. […] One of the most significant contributors to the development of lipomas is a genetic predisposition. Individuals with a family history of lipomas are more likely to develop these benign growths themselves. […] Another potential cause of lipomas is a medical condition known as adiposis dolorosa, also referred to as Dercum’s disease. […] Beyond genetics and medical conditions, the exact triggers for lipoma formation are less understood. Some hypotheses suggest that physical trauma or injury to fatty tissue areas may lead to the growth of lipomas in some individuals. […] In some cases, lipomas may occur without an apparent cause, leading to a classification as „idiopathic lipomas.” […] Lipomas can affect individuals of all ages and genders, but they are more commonly observed in adults between the ages of 40 and 60.

• #70 Lipoma Pathology – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK482343/

  While the etiology of lipomas is unclear, some studies have shown a genetic link, whereby about two-thirds of lipomas demonstrate genetic abnormalities. […] In addition to the possibility of a genetic link, another theory presents the idea that there is a direct positive correlation between trauma to an area and lipoma production. Research shows a link between adipose tumor growth as a post-traumatic event following a direct impact on that area of soft tissue. […] In addition to the risk factors listed above, other possible connections that may lead to lipomas are obesity, alcohol abuse, liver disease, as well as glucose intolerance.

• #71 Lipoma Reasons: Causes, Symptoms, Types, Treatments – Southlake General Surgery

  https://www.southlakegeneralsurgery.com/lipoma-reasons-causes-symptoms-types-treatments/

  Lipomas are common benign tumors that develop in the fatty tissue just below the skin. […] While the exact cause of lipoma formation is unknown, genetic factors and lifestyle factors such as obesity may play a role. […] Genetic factors play a role in certain cases, as lipomas can run in families. Lifestyle factors, such as obesity, have also been associated with an increased risk of developing lipomas. […] The exact cause of lipoma formation is not well understood. However, research suggests that there may be both genetic and lifestyle factors that contribute to the development of lipomas. […] Understanding the genetic factors involved in lipoma formation can provide valuable insights into the development, diagnosis, and management of this condition. […] Obesity has been linked to a higher likelihood of developing lipomas. Excess body fat and adipose tissue may create an environment that promotes the growth of lipomas.

• #72 Lipomas: Causes, Symptoms, Diagnosis, and Treatment

  https://www.valleyskininstitute.com/lipomas-harmless-lumps-or-a-cause-for-concern/?srsltid=AfmBOooFCv3M0Fcy1P8BJ6YJgKa7ChqmlcKzc4_AIH4ZER9cKVvvIeIr

  However, a rare type of cancer called liposarcoma, can develop in the fat cells. Liposarcoma is not a benign lipoma turned malignant but a separate, rare, and aggressive form of cancer. It behaves very differently from a lipoma, multiplying, often invading surrounding tissues, and potentially spreading to other parts of the body.

• #73 Lipoma Risks and Causes: Everything You Need to Know

  https://luxhospitals.com/blog/general-surgery/lipomas-risks-and-causes/

  The main risks of lipomas are related to their size and location. Large lipomas may cause pain, pressure on nearby structures, or restricted movement. They may also lead to cosmetic concerns, depending on their visibility. […] Lipomas are generally non-cancerous, but in rare cases, they can develop into a form of cancer known as liposarcoma. However, this is extremely uncommon.

• #74 Lipoma and Atypical Lipomatous Tumors – OrthoInfo – AAOS

  https://orthoinfo.aaos.org/en/diseases–conditions/lipoma

  A lipoma is a benign (noncancerous) tumor made up of fat tissue. It is the most common soft tissue tumor found in adults. […] The cause of lipomas is not completely understood. Some subtypes (conventional lipomas, spindle cell lipomas, pleomorphic lipomas) appear to have a genetic cause and may be inherited from family members. […] There has been no proven connection between the development of lipomas and any particular occupation or exposure to chemicals or radiation. Some doctors think that lipomas occur more often in inactive people. […] There is ongoing research to learn more about the various subtypes of lipomas and why they form in the first place.

• #75 Lipoma Causes and Treatment: A Comprehensive Guide – Cosmo aid

  https://cosmoaid.com/lipoma-causes-and-treatment/

  Lipoma, a relatively uncommon condition, refers to the development of benign fatty tumors called adipose tumors. […] Research suggests that genetic predisposition may play a significant role in the development of lipoma. Individuals with a family history of adipose tumor are more likely to develop them themselves. Specific genetic mutations may also contribute to the formation of these benign tumors. […] Certain environmental factors, such as obesity and high cholesterol levels, have been linked to an increased risk of developing lipoma. Additionally, trauma or injury to the affected area may trigger the growth of adipose tumor in some cases. […] Ongoing research into the causes and mechanisms of adipose tumor formation aims to identify new treatment targets and improve existing therapeutic approaches. […] Genetic and environmental factors can contribute to the development of adipose tumors, and various treatment modalities are available depending on the severity and symptoms of the condition.

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