Materiały źródłowe

• #1 Seborrheic Keratosis – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/sites/books/NBK545285/

  Seborrheic keratosis is the most common benign skin tumor, affecting over 80 million Americans. Individuals older than 50 years of age typically develop seborrheic keratosis, which becomes more pronounced as they age. Although seborrheic keratoses are more common in middle-aged and older patients, they can also be present in young adults. There is no difference in prevalence between males and females. However, seborrheic keratosis appears more frequently in populations with lighter skin tones. […] Given the prevalence of these tumors, it is important to understand the workup and various treatment modalities for seborrheic keratosis management. […] Patients with large numbers of seborrheic keratoses need screening, as there can be an increased chance of missing coexisting malignant skin lesions.

• #2 Current Understanding of Seborrheic Keratosis: Prevalence, Etiology, Clinical Presentation, Diagnosis, and Management – JDDonline – Journal of Drugs in Dermatology

  https://jddonline.com/articles/current-understanding-of-seborrheic-keratosis-prevalence-etiology-clinical-presentation-diagnosis-an-S1545961615P1119X

  Seborrheic keratosis (SK) is among the most common cutaneous lesions, affecting some 83 million Americans. […] Data regarding SK prevalence and management from a survey of 594 practicing, board-certified dermatologists are summarized herein: Dermatologists report they diagnose an average of 155 patients per month with SK. […] On average, dermatologists treat 43% of their SK patients to remove lesions. […] While there is great interest from both patients and providers in a topical non-invasive treatment for SK, no effective topical therapeutic agent has been developed, and this remains an area of unmet need.

• #3 Seborrheic Keratosis – EyeWiki

  https://eyewiki.org/Seborrheic_Keratosis

  Seborrheic keratosis is one of the most common benign epidermal skin tumors and affects over 80 million Americans. […] The increased prevalence of SK with increasing age is well known, particularly in those over 50 years of age, in which 80-100% of SK is detected. […] A recent study found an average of 69 SK lesions per person in individuals over the age of 75. […] SK appears to occur more frequently in individuals with lighter skin tones, especially in patients with a Fitzpatrick skin type 3 or less.

• #4 Current Understanding of Seborrheic Keratosis: Prevalence, Etiology, Clinical Presentation, Diagnosis, and Management.

  https://vivo.weill.cornell.edu/display/pubid26461823

  Seborrheic keratosis (SK) is among the most common cutaneous lesions, affecting some 83 million Americans. […] Data regarding SK prevalence and management from a survey of 594 practicing, board-certified dermatologists are summarized herein: Dermatologists report they diagnose an average of 155 patients per month with SK. Among SK patients presenting to dermatologists, 33% have more than 15 SK lesions and 67% have 15 or fewer SK lesions. […] On average, dermatologists treat 43% of their SK patients to remove lesions.

• #5 Seborrheic keratosis – UpToDate

  https://www.uptodate.com/contents/seborrheic-keratosis

  Seborrheic keratosis (SK) is one of the most common, if not the most common, benign skin tumors occurring in adults and older individuals of all ethnicities without sex predilection. Its prevalence increases with age, reaching nearly 100 percent in individuals older than 60 years.

• #6 Seborrheic Keratosis: Background, Pathophysiology, Etiology

  https://emedicine.medscape.com/article/1059477-overview

  Seborrheic keratoses are the most common benign tumor in older individuals. The frequency appears to increase with age. In 1963, Tindall and Smith examined a population of individuals older than 64 years in North Carolina and found that 88% of the people had at least one seborrheic keratosis. In this study, 38% of the white women, 54% of the white men, and 61% of the black men and women were found to have 10 or more seborrheic keratoses. In 1965, Young examined 222 residents of the Orthodox Jewish Home for the Aged in New York and found that 29.3% of the men and 37.9% of the women had seborrheic keratosis. […] Seborrheic keratoses are less common in populations with dark skin compared to those having white skin; however, black individuals develop a variant of seborrheic keratoses termed dermatosis papulosa nigra. These lesions affect the face, especially the upper cheeks and lateral orbital areas. They are small, pedunculated, and heavily pigmented with a minimal keratotic element. The onset of these lesions generally is earlier than that of ordinary seborrheic keratoses. […] No sex difference is apparent in the frequency of occurrence of seborrheic keratoses. […] Seborrheic keratoses are the most common benign tumor in older individuals. They appear to increase with age. Seborrheic keratoses have also been found to occur in younger individuals.

• #7 Spectrum of seborrheic keratoses in south Indians: A clinical and dermoscopic study – Indian Journal of Dermatology, Venereology and Leprology

  https://ijdvl.com/spectrum-of-seborrheic-keratoses-in-south-indians-a-clinical-and-dermoscopic-study/

  The most common age group affected by SK was 60 years and above (40%). […] The frequency of SK appears to increase with age. […] In our study, 250 patients are with SK. The most common age group affected by SK was 60 years and above (100 cases, 40%), followed by 51-60 years (64 cases, 25.5%), 41-50 years (45 cases, 17.9%), 31-40 years (29 cases, 11.6%) and less than 30 years (12 cases, 4.8%) showing a clear correlation of SK with age as mentioned in the literature. […] The most common clinical variant was common seborrheic keratoses (CSK) (150 cases, 60%) […] The existing literature mentions that CSK are usually seen after the third decade, whereas the youngest patient with CSK in our study was a 12-year-old female, although only 8.6% of total cases (n= 13) with CSK were in the age group less than 40 years.

• #8 Seborrheic Keratosis

  http://www.thedoctorsdoctor.com/diseases/seborrheic_keratosis.htm

  The prevalence of seborrhoeic keratoses in an Australian population: does exposure to sunlight play a part in their frequency? […] Although seborrhoeic keratoses (SKs) appear to be very common, there are very few studies reporting details of age-specific prevalence, distribution or possible cause. […] We report details on the frequency, nature and distribution of SKs in 100 Australian adults in the age groups 15-25, 26-50, 51-75 and those aged more than 75 years. […] There was an increase in prevalence of SKs from 12% of 15-25 year olds to 100% of those aged more than 50 years. […] The data in this study demonstrate an increased frequency of SKs compared with those reported from the United Kingdom recently and from Australasia in the past, a phenomenon paralleling the changing frequency of skin cancer in these populations.

• #9 Seborrheic keratosis – Wikipedia

  https://en.wikipedia.org/wiki/Seborrheic_keratosis

  Seborrheic keratosis is the most common benign skin tumor. Incidence increases with age. There is less prevalence in people with darker skin. In large-cohort studies, all patients aged 50 and older had at least one seborrheic keratosis. Onset is usually in middle age, although they are common in younger patients too, as they are found in 12% of 15-year-olds to 25-year-olds, which makes the term „senile keratosis” a misnomer.

• #10 Seborrheic Keratosis

  http://www.thedoctorsdoctor.com/diseases/seborrheic_keratosis.htm

  The prevalence of seborrheic keratoses in people aged 15 to 30 years: is the term senile keratosis redundant? […] To determine the prevalence, nature, and distribution of SKs in young people. […] Forty (23.5%) of 170 respondents had at least one SK, with no significant difference between the sexes. […] There was an increase in prevalence with age from 15.7% in 15- to 19-year-olds to 32.3% in those aged 25 to 30 years. […] These findings confirm that SKs are common lesions in young Australians, appearing in a substantial proportion of people younger than 30 years.

• #11 Giant Seborrheic Keratoses: An Historical Case

  https://clinmedjournals.org/articles/cmil/cmil-7-174.php?jid=cmil

  Seborrhoeic keratoses are benign tumors that mainly occur in the head and in the trunk. […] Despite the frequency of seborrheic keratosis, little is known about the epidemiology of the disorder. It is believed to be more prevalent among Caucasians and to affect roughly equal numbers of men and women. It is also generally acknowledged that its prevalence increases with advancing age. One Australian study reported a 100% prevalence of seborrheic keratoses among people over age 50. On average, 69 seborrheic keratoses were found per patient in those over age 75. […] The etiology of Seborrhoeic keratoses is unknown, although there may be some familial predisposition, which was not demonstrated in our patient. They could also occur after inflammatory dermatosis or at a site of repeated rubbing. […] Seborrhoeic keratoses which are located on sites of chronic friction, such as shaving areas, or the folds of obese patients, can reach large dimensions, up to ten centimeters in diameter.

• #12 Management of seborrheic keratosis in elderly patients | CCID

  https://www.dovepress.com/differential-diagnosis-and-management-on-seborrheic-keratosis-in-elder-peer-reviewed-fulltext-article-CCID

  Seborrheic keratoses are exceedingly common in the elderly and usually are easy to diagnose and do not require treatment. […] Accurate and updated information about SK epidemiology are missing; however, it is well known that the prevalence of SK increases with increasing age. A higher prevalence among people with skin of color has also been reported. In a study in US in 1963, Tindall and Smith examined a population of individuals older than 64 years and found that 88% of the people had at least one seborrheic keratosis. […] No sex difference has ever been reported for SKs.

• #13 Pathology Outlines – Seborrheic keratosis

  https://www.pathologyoutlines.com/topic/skintumornonmelanocyticsk.html

  Most common benign skin tumor […] Age > 50; incidence increases with age […] M = F […] Lighter skinned individuals.

• #14 Keratosis, Seborrheic | 5-Minute Clinical Consult

  https://www.unboundmedicine.com/5minute/view/5-Minute-Clinical-Consult/1688483/1.1/Keratosis__Seborrheic

  Predominant age: appear most commonly in those aged 31 to 50 years, and incidence increases with age, peaking at age 60 years […] Predominant sex: slightly more common and more extensive involvement in males […] Most common among Caucasians, except for the dermatosis papulosa nigra variant, which usually presents in darker skinned individuals […] The prevalence rate increases with advancing age.

• #15 Key Features of Dermatosis Papulosa Nigra vs Seborrheic Keratosis | MDedge

  https://blogs.the-hospitalist.org/content/key-features-dermatosis-papulosa-nigra-vs-seborrheic-keratosis

  The incidence of SKs increases with age. Although it can occur in patients of all skin tones, SK is more common in lighter skin tones, while DPN predominantly is diagnosed in darker skin types. The prevalence of DPN in Black patients ranges from 10% to 30%, and Black women are twice as likely to be diagnosed with DPN as men. One study reported a first-degree relative with DPN in 84% (42/50) of patients. The number and size of DPN papules increase with age. […] It is important to exercise caution when using abrasive methods (eg, laser therapy, electrodesiccation, curettage) in patients with darker skin tones because of the increased risk for postinflammatory pigment alteration. Adverse effects of treatment are a top concern in the management of DPN. While cryotherapy is a preferred treatment of SK in lighter skin tones, it generally is avoided for DPN in darker skin types because melanocyte destruction can lead to cosmetically unsatisfactory and easily visible depigmentation. […] Despite the high prevalence of DPN in patients with darker skin tones, data on treatment frequency and insurance coverage are not widely available, thus limiting our understanding of treatment accessibility and economic burden.

• #16 Berkala Ilmu Kesehatan Kulit dan Kelamin

  https://e-journal.unair.ac.id/BIKK/article/view/42576

  Seborrheic keratosis (SK) and acrochordon are common benign neoplasms of the skin that can be diagnosed clinically. […] Epidemiologic data for these entities is rare in Indonesia. […] To determine the epidemiology of SK and acrochordon patients at the Dermatology Venereology (DV) Clinic, dr. Cipto Mangunkusumo National Central General Hospital (RSCM). […] In the four-year period, there were 1.202 SK patient visits with 447 new cases and 374 acrochordon patient visits with 169 new cases. The proportion of SK patients in this study was 2.2%; acrochordon was 1.8% of all patients at the DV Clinic of RSCM. […] The highest prevalence of SK was found in patients older than the 6th decade, while for acrochordon, it was within the 4th decade. […] Both SK and acrochordon were seen higher in women, with a male-to-female ratio of 1:2. […] Seborrheic keratosis and acrochordon proportion, respectively, are 2.2% and 1.8% at the DV Clinic, RSCM. […] Seborrheic keratosis and acrochordon are more frequent in women, with the peak occurring in 6th decade and 4th decade, respectively.

• #17

  https://journals.lww.com/jdnaonline/fulltext/2022/03000/seborrheic_keratoses_are_not_indicative_of.3.aspx

  SKs appear mainly on the face and the seborrheic areas (the inaccurate source of their namethey are unrelated to seborrhea or sebaceous glands) of the trunk. […] Furthermore, Neither painful sunburns nor lifetime sun exposure were associated with an increased risk of seborrheic warts (Kennedy et al., 2003). […] In a related study, Seborrheic keratoses are common in the Korean males. Both aging and cumulative sunlight exposure were found to be independent contributory factors (Kwon et al., 2003). […] Further adding to the ambiguity, studies have shown more frequent occurrence and earlier age of onset in those residing in tropical climates as well as a higher prevalence of SKs on sun-exposed areas in those subjects (Bolognia et al., 2012). […] Nevertheless, for most of the patients whom we see, SKs are completely benign (if unsightly); I am not sure if it is fair to say they are indicative of sun damage.

• #18 Seborrhoeic keratoses (brown warts, basal cell papillomas, seborrheic keratosis)

  https://dermnetnz.org/topics/seborrhoeic-keratosis

  Seborrhoeic keratoses are extremely common. It has been estimated that over 90% of adults over the age of 60 years have one or more of them. They occur in males and females of all races, typically beginning to erupt in the 30s or 40s. They are uncommon under the age of 20 years. […] The precise cause of seborrhoeic keratoses is not known. […] Seborrhoeic keratoses are considered degenerative in nature. As time goes by, seborrhoeic keratoses become more numerous. Some people inherit a tendency to develop a very large number of them. […] Eruptive seborrhoeic keratoses can follow sunburn or dermatitis. […] Stable and clonal mutations or activation of FRFR3, PIK3CA, RAS, AKT1 and EGFR genes are found in seborrhoeic keratoses. […] FRFR3 mutations also arise in solar lentigines. These mutations are associated with increased age and location on the head and neck, suggesting a role of ultraviolet radiation in these lesions.

• #19 Giant Seborrheic Keratoses: An Historical Case

  https://www.clinmedjournals.org/articles/cmil/cmil-7-174.php?jid=cmil

  The etiology of Seborrhoeic keratoses is unknown, although there may be some familial predisposition, which was not demonstrated in our patient. […] The treatment of giant Seborrhoeic keratoses can combine several means at the same time, in particular cryotherapy and electrocoagulation-curettage; in some cases, it may require surgery.

• #20 Seborrheic Keratosis: What Is It, Causes, Risks & Treatment

  https://my.clevelandclinic.org/health/diseases/21721-seborrheic-keratosis

  Seborrheic keratoses are not pre-cancerous, but they can resemble other skin growths that are. […] They tend to appear in mid-adulthood and their frequency increases with age. […] About 30% of people have at least one by the age of 40, and about 75% by the age of 70. […] Some studies suggest that sun exposure may increase their occurrence. […] They also appear more frequently in families, which suggests that genetics may play a role. […] Seborrheic keratoses usually grow slowly and may develop their texture gradually over time. […] If many seborrheic keratoses erupt suddenly together, it might raise some concern. […] This unusual occurrence has sometimes been considered a sign of internal cancer. […] Seborrheic keratosis and actinic keratosis can resemble each other. […] It’s important to know the difference because actinic keratosis is more serious than seborrheic keratosis.

• #21 Advancing the Understanding of Seborrheic Keratosis – JDDonline – Journal of Drugs in Dermatology

  https://jddonline.com/articles/advancing-the-understanding-of-seborrheic-keratosis-S1545961617P0419X

  The seborrheic keratosis, which is ubiquitous throughout all populations, is a benign tumor of the skin. Seborrheic keratosis are among the top 20 dermatologic conditions treated by dermatologists. They have been reported to occur in individuals of all ages including children as young as age 15 years. Familial cases of seborrheic keratosis (SK) have been described with an autosomal dominant inheritance pattern. Mutations of the fibroblast growth factor receptor 3 gene (FGFR3) and the gene encoding for phosphoinositide 3-kinase (PIK3CA) have been demonstrated in SKs. In addition to a genetic predisposition, independent risk factors include advancing age and ultraviolet light exposure. […] The top 20 dermatologic conditions reported by dermatologists accounted for 85.4% of all diagnoses made by dermatologists and SKs were included in these conditions. Bickers estimated the prevalence of skin diseases in the United States (US) and determined that 83.3 million people in the US had SKs with direct health care cost due to SKs of $1092 million, indirect cost of $113 million (from lost productivity), and intangible cost of $6700 million (because of QOL impact).

• #22 Advancing the Understanding of Seborrheic Keratosis – JDDonline – Journal of Drugs in Dermatology

  https://jddonline.com/articles/advancing-the-understanding-of-seborrheic-keratosis-S1545961617P0419X

  Familial cases of SKs have been described in the literature with a report of a German family with at least seven affected members in two generations and the onset of a large number of SKs at a young age. An autosomal dominant inheritance pattern has been identified in some families with familial SKs. […] In addition to a genetic predisposition, independent risk factors for the development of SKs that have been proposed including advancing age and ultraviolet light exposure. […] These two risk factors may also contribute to the development of SKs caused by the genetic mutation in the FGFR3 gene, which is involved in regulating cell growth differentiation, migration, and wound healing. […] Although diagnosis is primarily clinical, mimickers of SKs are well known with melanoma being the most concerning. Treatment of the SK is primarily procedural with new treatments in development.

• #23 Seborrheic Keratosis

  https://fpnotebook.com/Derm/Hyperplasia/SbrhcKrts.htm

  Most common benign epithelial tumor. […] More common in patients over age 30 years old. […] Number of lesions increase with age. […] Men and women affected equally. […] Autosomal Dominant inheritance.

• #24 Seborrheic Keratosis: Symptoms and Treatment | Lupton Dermatology

  https://www.luptondermatology.com/conditions/seborrheic-keratosis

  Seborrheic keratosis is more common with age and tends to run in families. […] Prolonged exposure to the sun’s ultraviolet (UV) rays may contribute to the development of seborrheic keratosis. […] While genetics and aging are primary factors, excessive sun exposure may contribute to the development of seborrheic keratoses. Protecting your skin from the sun can help minimize their occurrence. […] Regular skin checks with a dermatologist are advisable to monitor any changes and address new developments.

• #25 Can My Seborrheic Keratosis Be Removed? – Franks Dermatology

  https://franksdermatology.com/can-my-seborrheic-keratosis-be-removed/

  Seborrheic keratosis is a common skin condition most prevalent in older adults. […] Seborrheic keratosis is commonly associated with aging, making it a frequent occurrence in middle-aged and older adults. […] Individuals over the age of 50 are more likely to develop these growths. […] There’s a hereditary component to seborrheic keratosis. […] A family history of seborrheic keratosis increases the likelihood of developing it. […] Prolonged exposure to the sun is believed to be a contributing factor, particularly in people with lighter skin. […] Seborrheic keratosis is generally benign. […] Regular self-examination and dermatological checkups are key practices in maintaining skin health and catching potential issues early. […] Because it’s typically benign, seborrheic keratosis doesn’t usually require removal unless it’s for cosmetic reasons, discomfort, or diagnostic purposes.

• #26 Seborrheic Keratosis and Aging | Tru-Skin Dermatology

  https://www.tru-skin.com/blog/seborrheic-keratosis-and-aging

  Seborrheic keratosis typically appears more frequently as people age. […] Several key factors contribute to the increased prevalence of these growths as you get older: […] One of the most significant risk factors for developing seborrheic keratosis is prolonged exposure to ultraviolet (UV) light. […] Genetics also play a role in the development of seborrheic keratosis. […] Hormonal shifts, particularly during menopause, can affect the skin’s structure and function. […] Repeated friction or irritation can promote the formation of seborrheic keratosis. […] Seborrheic keratosis is a common, benign condition that becomes more prevalent with age. […] Regular skin exams, especially for those with a history of sun exposure or genetic risk factors, are essential for monitoring your skin health.

• #27 Seborrheic Keratosis > Fact Sheets > Yale Medicine

  https://www.yalemedicine.org/conditions/seborrheic-keratosis

  Seborrheic keratosis is the most common type of benign skin lesion. About 80 million Americans have one or more of these non-cancerous growths on their skin. […] Although they can affect teenagers or young adults, the growths are most common among adults aged 50 and older. They occur more frequently with age; more than 90% of adults aged 65 and older are believed to have at least one seborrheic keratosis. Men and women are affected equally. […] People are more likely to develop seborrheic keratosis if they: Are age 50 or older, Have spent a significant amount of time sunbathing or with the skin exposed to the sun, Have a family history of seborrheic keratosis, Have an FGFR3 genetic mutation, Have a PIK3CA genetic mutation, Are pregnant, Have taken hormone therapy. […] A dermatologist typically diagnoses seborrheic keratosis. The growths are usually discovered during a physical examination, then confirmed with a biopsy when needed.

• #27 Seborrheic Keratosis > Fact Sheets > Yale Medicine

  https://www.yalemedicine.org/conditions/seborrheic-keratosis

  In most cases, no treatment is necessary for seborrheic keratosis. Sometimes, the growths are removed because their location leads to chronic irritation or bleeding. Other times, people choose to have them removed for cosmetic reasons. […] Seborrheic keratosis should not affect a persons overall health, unless it is identified as seborrheic keratosis due to the Leser-Trlat sign. In that case, the person may need treatment for non-skin cancer, such as lymphoma or cancer of the gastrointestinal tract. However, the skin growths themselves should not affect an individuals prognosis.

• #28 Benign But Bothersome: A Closer Look at Seborrheic Keratosis

  https://www.medscape.org/sites/advances/seborrheic-keratosis

  Seborrheic keratosis is a common noncancerous skin growth affecting over 80 million Americans. […] Clinicians must carefully assess and diagnose seborrheic keratoses as they can mimic malignant tumors. […] Current Understanding of Seborrheic Keratosis: Prevalence, Etiology, Clinical Presentation, Diagnosis, and Management. […] A Closer Look at Seborrheic Keratoses: Patient Perspectives, Clinical Relevance, Medical Necessity, and Implications for Management.

• #29 Seborrheic keratosis – Symptoms, diagnosis and treatment | BMJ Best Practice US

  https://bestpractice.bmj.com/topics/en-us/617

  Seborrheic keratoses are common, multiple, benign tumors of the skin. […] They usually appear in the fourth and fifth decades of life and their prevalence increases with age and sun exposure. […] Most important differential diagnosis, and of patient concern, is malignant melanoma. […] Risk factors include age over 50 years, Fitzpatrick skin type I or II, Fitzpatrick skin type IV, V, or VI (dermatosis papulosa nigra), female sex (dermatosis papulosa nigra), family history, sun/UV exposure, and pregnancy.

• #30 Seborrheic Keratosis: What Is It, Causes, Risks & Treatment

  https://my.clevelandclinic.org/health/diseases/21721-seborrheic-keratosis

  Seborrheic keratosis doesn’t turn into melanoma, but the two can be mistaken for each other. […] Seborrheic keratoses often appear in numbers, while melanoma is usually single. […] Seborrheic keratoses are well-defined, while melanoma can have a ragged or blurry border. […] You should always have new skin growths clinically diagnosed to make sure they aren’t cancerous. […] If your healthcare provider is in any doubt about your growth, they might want to remove it for biopsy. […] If it is clearly a seborrheic keratosis, it won’t require any treatment. […] You might want to have it removed if it becomes itchy or irritated or you don’t like the look of it. […] Seborrheic keratosis is nothing to worry about, but you should have it diagnosed just to make sure it isn’t something else that could be more harmful.

• #31 Seborrheic Keratosis – Pennsylvania Dermatology Specialists

  https://www.penndermspecialists.com/seborrheic-keratosis/

  Seborrheic keratoses are very common across all races. It has been estimated that over 9 in 10 adults that are above the ages of sixty years have one or more of them. They occur equally in both sexes and usually begin to erupt between the ages of thirty to forty years. They are not common under the age of twenty years. […] Dermoscopy is an effective method to diagnose seborrheic keratosis, particularly if there is a need to distinguish it from skin cancer. It is important to let the experts at Pennsylvania Dermatology Specialists diagnose and manage any skin lesions you have; we are experts in dermoscopy and non-invasive diagnosis.

• #32 Spectrum of seborrheic keratoses in south Indians: A clinical and dermoscopic study – Indian Journal of Dermatology, Venereology and Leprology

  https://ijdvl.com/spectrum-of-seborrheic-keratoses-in-south-indians-a-clinical-and-dermoscopic-study/

  In our study, 46.4% (116) of cases (48 males and 68 females, M:F ratio 1:1.42) had DPN with females outnumbering males. […] We observed that both DPN and PSK were common in females, manifesting at earlier ages than other variants of SK. […] The commonest dermoscopic findings seen in CSK (n = 150) were CL (n = 121, 80%), SD (n = 124, 82.6%), and FR (FR) (n = 78.58%) and less common findings were ME (n = 47, 31.3%), ML (n = 36, 24%), and NL (n = 6, 4%). […] DPN (n = 116) showed only three findings, i.e. CL (n = 95, 85.3%), and FR (n = 91, 78.4%) being the commonest and SD in 20 cases (17.2%).

• #33 Seborrheic keratosis: Treatment, images, and symptoms

  https://www.medicalnewstoday.com/articles/266748

  Seborrheic keratoses are very common. More than 80 million people in the United States have seborrheic keratoses. They can occur at any age but are most common after 50 years. […] People with multiple seborrheic keratoses may wish to make a yearly appointment with a dermatologist to check for changes that could be cancerous. […] Anyone with a large number of seborrheic keratoses requires careful screening, as there is an increased chance of missing any cancerous lesions.

• #34 Seborrhoeic keratoses (brown warts, basal cell papillomas, seborrheic keratosis)

  https://dermnetnz.org/topics/seborrhoeic-keratosis

  Seborrhoeic keratoses do not harbour tumour suppressor gene mutations. […] Seborrhoeic keratoses are not premalignant tumours. However: Skin cancers are sometimes difficult to tell apart from seborrhoeic keratoses. […] Very rarely, eruptive seborrhoeic keratoses may denote an underlying internal malignancy, most often gastric adenocarcinoma. […] Eruptive and irritated seborrhoeic keratoses may also arise as an adverse reaction to a medication, such as adalimumab, vemurafenib, dabrafenib, 5-fluorouracil and many chemotherapy drugs. […] How to prevent seborrhoeic keratoses is unknown. […] Seborrhoeic keratoses tend to persist. From time to time, individual or multiple lesions may remit spontaneously or via the lichenoid keratosis mechanism.

• #35 Seborrheic keratosis – Therapeutics in Dermatology

  https://www.therapeutique-dermatologique.org/spip.php?article1554

  Seborrheic keratoses or seborrheic warts are harmless and common skin lesions which are particularly prevalent in the elderly. They are the most frequently observed form of benign epithelial tumour. […] In most cases, they emerge in the fifth decade of life in both men and women but may also affect teenagers. […] The aetiology of these tumours is unknown. Solar exposure and heredity have been put forward as possible predisposing factors. There is often an identical family history; these lesions frequently arise in sun-exposed areas. […] Seborrheic keratoses may co-exist with other benign and malignant tumours (collision tumours). Leser-Trlat sign is the explosive onset of multiple, itchy seborrheic keratosis. This can be an ominous indication of an underlying solid tumour, most often stomach cancer or a colon adenocarcinoma, more rarely breast cancer or melanoma. […] In most cases, this condition is easy to diagnose, simply on the basis of the clinical findings. […] Dermoscopy can be a useful means of confirming the clinical diagnosis.

• #36 Comparative study on the age-related incidence of seborrheic keratosis and verruca plana in patients with verruca plana-like lesions | Scientific Reports

  https://www.nature.com/articles/s41598-024-55617-1

  Seborrheic keratosis (SK) is a common skin disease in the elderly. […] This retrospective study investigated the prevalence of SK and VP in the lesions that appear clinically similar to VP according to age. […] SK had a higher prevalence among individuals older than 30 years, and relative frequency of SK should not be ignored in patients with a grouped distribution in their 20 s and 30 s. […] Therefore, our study suggests that multiple verrucous skin-colored to brownish plaques are also commonly diagnosed as SK in young people as well as VP, and the prevalence of SK and VP may not always depend solely on chronological aging, and the prevalence of SK among young people may be higher than commonly believed stereotypes suggest. […] In our study, among 503 patients with VP-like lesions, 34.6% were diagnosed with SK, whereas 26.2% were diagnosed with VP, based on histopathological results.

• #37 Comparative study on the age-related incidence of seborrheic keratosis and verruca plana in patients with verruca plana-like lesions | Scientific Reports

  https://www.nature.com/articles/s41598-024-55617-1

  Among patients with SK and VP, the average ages at the time of diagnosis were 39.3 and 35.4 years, respectively. […] These findings suggested that clinically presented VP-like lesions were mostly SK, and the prevalence proportion of SK should not be ignored in patients in their 1920s and 1930s. […] According to some studies that have revealed the prevalence of SK, the mean age of patients with SKs has increased over time. […] They suggested that SK is also common in young people, and that the term senile keratosis, another term for SK, was no longer appropriate. […] In the present study, we observed that lesions clinically diagnosed as VP in young adults were also commonly diagnosed as SK. Despite the common conception that SK is diagnosed mostly in the elderly, we suggest that SK can occur in individuals of all age groups.

• #38 What Are Seborrheic Keratoses and How Are They Treated? – Allura Skin & Laser Center

  https://www.alluraskin.com/what-are-seborrheic-keratoses-and-how-are-they-treated/

  Seborrheic keratoses are a very common skin finding, and most people will develop at least a few throughout their lifetime. They are not a cause for concern, but if they are bothersome or you have any questions, its always best to consult a cosmetic surgeon. […] Seborrheic keratoses are more common in older adults, with their prevalence increasing with age. […] Seborrheic keratoses do not develop into skin cancer. They remain benign growths throughout their presence. […] Regular skin checks with your doctor can ensure that any new or changing growths are identified and evaluated promptly.

• #39 Seborrheic Keratosis: Symptoms and Treatment | Dermatology Affiliates

  https://www.dermatologyaffiliates.com/conditions/seborrheic-keratosis

  Most people will develop at least one seborrheic keratosis during a lifetime. […] Seborrheic keratoses are generally harmless and do not turn into cancer. They are considered benign growths, and while they may look similar to certain skin cancers, they pose no cancer risk. […] While genetics and aging are primary factors, excessive sun exposure may contribute to the development of seborrheic keratoses. Protecting your skin from the sun can help minimize their occurrence. […] Regular skin checks with a dermatologist are advisable to monitor any changes and address new developments.

• #40 Seborrheic Keratosis Specialist – Chevy Chase, MD: Ali Hendi, MD: Skin Cancer Specialist

  https://www.mohssurgerymd.com/services/seborrheic-keratosis

  A seborrheic keratosis is the most common noncancerous tumor in older adults. […] Seborrheic keratosis aren’t contagious and are generally harmless. […] Although the cause of seborrheic keratosis is unclear, the growths tend to run in families, suggesting genetics play a role. […] What is clear is seborrheic keratosis is more common with increased age. […] It’s best to contact the office of Ali Hendi, MD, if you’ve developed many of these growths over a short period. […] Your provider will want to rule out cancer. […] The team at the office of Ali Hendi, MD, examines the growth to determine whether it’s a seborrheic keratosis or skin cancer. […] You neednt worry about suspicious growths when the team of skin cancer specialists at the office of Ali Hendi, MD, offers prompt, effective diagnosis and care.

• #41 Seborrheic keratosis – patholines.org

  https://patholines.org/Seborrheic_keratosis

  Clinically, seborrheic keratosis generally occurs in elderly patients. […] The most important component is generally whether there is any evidence of malignancy.

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