Materiały źródłowe

• #1 Breast cancer chemoprevention: Drugs that reduce risk

  https://www.mayoclinic.org/diseases-conditions/breast-cancer/in-depth/breast-cancer/art-20045353

  Preventive medications can reduce breast cancer risk. […] If you’re at high risk of breast cancer, you may be able to improve your odds of staying cancer-free by taking certain medicines an approach known as chemoprevention or preventive therapy. […] Medications for breast cancer chemoprevention are the subject of much ongoing research. […] Tamoxifen is used to reduce the risk of invasive breast cancer if you’re at high risk and you’re 35 and older, whether or not you’ve gone through menopause. […] Raloxifene is used to reduce the risk of invasive breast cancer if you’re at high risk and you’ve undergone menopause (postmenopausal). […] Aromatase inhibitors have been studied and shown to be effective to treat breast cancer and to prevent breast cancer recurrence after menopause. […] Aromatase inhibitors, specifically exemestane and anastrozole, have also been studied to see if they may reduce the risk of breast cancer in people at high risk, such as those with a family history of breast cancer or a history of precancerous breast lesions.

• #2 Prevention of Late Recurrence: An Increasingly Important Target for Breast Cancer Research and Control

  https://pmc.ncbi.nlm.nih.gov/articles/PMC8902437/

  Breast cancer recurrence has become an increasingly important aspect of cancer control as the number of breast cancer survivors continues to increase. […] It was previously thought that the risk of recurrence decreases 5 years after diagnosis; however, an increasing body of literature has sustained a considerable risk of late recurrence beyond the canonical time frame. […] The authors investigated the risk of late breast cancer recurrence for up to 32 years after the primary diagnosis. […] This is the first report, to our knowledge, providing evidence that recurrence risk remains elevated more than 3 decades from the primary diagnosis. […] These findings further support the need for extended surveillance, more aggressive treatment, or new therapy approaches. […] Considering the effect of extended vs shorter surveillance periods may thus be warranted when evaluating the association therapeutic approaches and late recurrence outcomes. […] To expand our understanding of late breast cancer recurrence, it will be critical to continue to prospectively collect data that support recurrence research.

• #2 What Helps to Prevent Breast Cancer Recurrence

  https://www.webmd.com/breast-cancer/breast-cancer-recurrence-prevention

  Keep Up With Exercise […] Research shows that lifestyle changes and medications can help you stay as healthy as possible and may help reduce your risk of having cancer again. […] If you do choose to drink, make sure to limit it to only one drink a day to lower your chances of your cancer coming back. […] If you’ve had some of your breast removed as part of cancer treatment, you may need to get a mammogram, a scan that checks for breast cancer, every six to 12 months after treatment. […] After you complete your cancer treatment, if you have a high chance of your cancer returning, your doctor may prescribe certain drugs to reduce your risk. […] Tamoxifen is one such drug. Doctors often prescribe this drug to lower the chances of cancer coming back in women who have been treated for early-stage, hormone receptor-positive breast cancer.

• #2 What Helps to Prevent Breast Cancer Recurrence

  https://www.webmd.com/breast-cancer/breast-cancer-recurrence-prevention

  While rare, tamoxifen can also cause blood clots in your leg veins or lungs. This can be a serious side effect that may need medical attention right away. […] If you have a high risk of breast cancer coming back, aromatase inhibitor (AI) drugs may be another option. […] It’s important to take the time to heal and prioritize your overall emotional and mental health, along with your physical health. […] Keep in mind that if breast cancer does come back, it is not your fault and it can often be treated.

• #3 Breast Cancer Recurrence: Rates, Signs & Treatment

  https://my.clevelandclinic.org/health/diseases/8328-breast-cancer-recurrence

  Research shows certain treatments may reduce the risk that certain breast cancer subtypes will come back. For example, hormone therapy, like tamoxifen or aromatase inhibitors, may reduce the risk of recurrence for people with early-stage estrogen-receptive breast cancer (ER-positive or ER+). Likewise, having chemotherapy after surgery (adjuvant therapy) may reduce your risk. […] While you may not be able to prevent recurrent breast cancer, doing breast self-examinations and having regular follow-up screenings may help your provider identify recurrent breast cancer before it spreads or while metastatic breast cancer tumors are relatively small and easier to treat.

• #4 FDA approval of new drug regimen helps reduce risk of breast cancer recurrence for patients with early-stage disease | UCLA Health

  https://www.uclahealth.org/news/story/fda-approval-new-drug-regimen-helps-reduce-risk-breast

  Approval is based on findings from the NATALEE clinical trial, which was led by UCLAs Dr. Dennis Slamon. […] Current treatment includes endocrine therapy which blocks or lowers the levels of estrogen production so cancer cells can’t use it to grow and spread but there is still a risk of the cancer coming back years later after the initial diagnosis. […] While ribociclib was already known to extend survival in advanced cases, its potential to prevent recurrence in early-stage breast cancer offers hope for curing many more patients. […] We found that adding ribociclib to the standard hormone therapy resulted in a relative reduction in the recurrence rate by as much as 25%, said Dr. Slamon, who was the first author of the study and principal investigator on the trial. […] This is a new option that we can now offer patients that can help further minimize their risk of cancer returning.

• #5 Breast cancer chemoprevention: Drugs that reduce risk

  https://www.mayoclinic.org/diseases-conditions/breast-cancer/in-depth/breast-cancer/art-20045353

  Based on these results, you and your health care provider may choose to use aromatase inhibitors to reduce the risk of breast cancer, though these drugs aren’t approved by the U.S. Food and Drug Administration for this use. […] As more results from research studies become available, health care providers will have a better idea of the long-term health implications for these drugs and their effectiveness in breast cancer chemoprevention.

• #6 :: JBC :: Journal of Breast Cancer

  https://ejbc.kr/DOIx.php?id=10.4048/jbc.2022.25.e39

  Bisphosphonates (BPs) have a powerful effect on reducing bone resorption and improving the survival of patients with breast cancer. We aimed to investigate the impact of BP treatment on the prevention of recurrence, metastasis, and death of breast cancer survivors in the perimenopausal period. […] The overall The HRs for disease-free survival (DFS) and overall survival (OS) in women who received BPs were 0.89 (95% CI, 0.830.97; p= 0.005), and 0.75 (95% CI, 0.630.89;p= 0.001), respectively. […] The results showed that BPs had a significant effect on the prevention of locoregional (HR, 0.64; 95% CI, 0.420.97;p= 0.04), bone (95% CI, 0.740.95;p0.001), and distant metastases (HR, 0.77; 95% CI, 0.620.94;p = 0.01). […] Although BPs have a promising effect on DFS, OS, and bone metastasis of perimenopausal women survivors of breast cancer, more RCTs are needed to evaluate their effect on other survivors outcomes.

• #7 :: JBC :: Journal of Breast Cancer

  https://ejbc.kr/DOIx.php?id=10.4048/jbc.2022.25.e39

  We conducted a systematic review to identify the effect of BPs on recurrence, death, and overall metastasis in perimenopausal women with a history of breast cancer. […] According to the results of the SWOG S0307 trial, clodronate, ibandronate, and zoledronic acid may provide similar DFS and OS benefits. […] According to the results of this meta-analysis suggest a promising effect of BPs on DFS, OS, locoregional, distant, and bone metastasis among perimenopausal women survivors of breast cancer.

• #8 Reducing the Risk of Breast Cancer Recurrence: an Evaluation of the Effects and Mechanisms of Diet and Exercise

  https://pmc.ncbi.nlm.nih.gov/articles/PMC5112289/

  In summary, epidemiological evidence supports the participation in PA before and after breast cancer diagnosis as a contributing factor in decreasing risk of breast cancer recurrence and mortality. […] Current recommendations set forth by ACSM, ACS, and the US Department of Health and Human Services encourage cancer survivors to follow exercise prescription for healthy age-matched adults which includes 150 min per week of moderate or 75 min per week of vigorous aerobic exercise. […] In evaluating evidence from RCTs involving diet, exercise, or combined diet and exercise interventions, the most consistent finding was that reductions in adiposity accompanied the most beneficial changes in breast cancer outcomes, including survival, risk of recurrence, or biomarkers associated with prognosis.

• #9 Adherence to cancer prevention guidance linked with reduced breast cancer recurrence, death risk | MDedge

  https://www.mdedge.com/familypracticenews/article/262761/breast-cancer/adherence-cancer-prevention-guidance-linked-reduced

  Among women with early-stage, high-risk breast cancer, strong adherence to prevention recommendations was linked with a significantly reduced risk of breast cancer recurrence and mortality in a new study. […] The authors note that, while medications are the foundation for breast cancer treatment, lifestyle interventions could be a safe and inexpensive additional strategy for delaying and preventing recurrence and death. […] “Such developments could be especially impactful for patients diagnosed with more aggressive tumors that do not respond well to current therapies,” they write.

• #10

  https://www.prevention.com/health/a20473170/prevent-breast-cancer-recurrence/

  Regular exerciseat least 2 hours a weekis „the most importance lifestyle factor” when it comes to decreasing your risk for recurrence, Dr. Warner says. […] But because exercise lowers inflammation and levels of hormones linked with recurrence, it appears to be your best defense against having to fight a second round. […] „Women who are overweight and or obese have a higher risk of recurrence than those who maintain a healthy body weight,” says Elisa Port, MD, chief of breast surgery at Mount Sinai Hospital’s Dubin Breast Center and an investigator with the Breast Cancer Research Foundation. […] „Drinking in moderation”that is, up to three or four drinks per week”is probably reasonable and safe,” Dr. Port says. […] „Being compliant with medications that have been prescribed is critically important to giving a woman the lowest possible risk of recurrence,” Dr. Port says.

• #11 Prevent Breast Cancer Recurrence: Expert Tips

  https://www.healthline.com/health/breast-cancer/prevent-breast-cancer-recurrence

  While theres no way to guarantee that breast cancer will never come back, medical oncologist Amy Tiersten, MD, shares how taking steps to stay healthy may also help prevent breast cancer recurrence. […] Exercise has definitely been proven to reduce the risk of breast cancer recurrence. Exercising as little as 30 minutes of walking 5 days a week (150 minutes per week total) substantially lowers the risk of recurrence. […] Studies have shown that maintaining a moderate weight after diagnosis may decrease the risk of recurrence. […] Managing stress is important for overall quality of life, but it has not specifically been proven to reduce the risk of recurrence. […] Try stress-management techniques like exercise, which can help with managing stress while also reducing your risk of breast cancer recurrence. […] Ask your oncologist about your individual risk of recurrence. You may be surprised to hear that its not as high as you think it is. […] Sometimes, seeking counseling to help manage a fear of recurrence can be helpful.

• #12 Reducing the Risk of Breast Cancer Recurrence

  https://www.verywellhealth.com/reducing-breast-cancer-recurrence-4688612

  Exercise or increasing physical activity as a way to reduce breast cancer recurrence has been mentioned so often that it’s easy to become immune to the news. […] Yet, of all measures to reduce recurrence risk, physical activity has the greatest amount of evidence to date. […] Moderate exercise (such as walking at two to three miles per hour) for three to five hours per week may reduce the risk of recurrence by up to 50%. […] Maintaining a healthy weight (or losing weight if needed) appears to lower the risk of breast cancer recurrence. […] While there has been some controversy over vitamin D levels and breast cancer, some studies have found that people assigned female at birth who have low 25-hydroxyvitamin D levels have a higher recurrence risk. […] A 2016 study published in JAMA looked at the risk of recurrence in people with early stage breast cancer over a seven-year period.

• #13 Preventing Recurrence – Europa Donna

  https://www.europadonna.org/prevention-and-breast-health/preventing-recurrence/

  Numerous studies have shown that healthy lifestyle factors can reduce breast cancer recurrence and improve outcomes. Having a healthy lifestyle may also help alleviate some of the effects of breast cancer and its treatment. […] Europa Donna is involved in research projects to gather more data on this topic and calls for more high-quality studies in this area. […] Women who have had breast cancer should engage in regular, moderate exercise of at least 30-60 minutes per day. […] There is consistent evidence from observational studies that physical activity is associated with reduced breast cancer specific mortality. Studies indicate that getting at least 2.5 hours of exercise per week reduces the likelihood of breast cancer recurrence and mortality. […] Lifestyle factors to reduce the risk of recurrence: the St. Gallen Panel supported use of an exercise regimen and weight loss (or at least avoidance of weight gain). High levels of physical activity may improve survival in postmenopausal women with breast cancer, even among those reporting low physical activity prior to diagnosis.

• #14 Reducing the Risk of Breast Cancer Recurrence: an Evaluation of the Effects and Mechanisms of Diet and Exercise

  https://pmc.ncbi.nlm.nih.gov/articles/PMC5112289/

  Thus, the reduced risk of recurrence observed in HF-negative women in the diet intervention group compared to HF-negative women in the comparison group was attributed to lower estrogen levels from the low-fat, high fruit, and vegetable diet. […] The authors concluded that a low-fat, high vegetable, and fruit intake diet did not reduce recurrence events or provide survival benefit to women with early-stage breast cancer. […] Despite the limited evidence supporting diet interventions in preventing breast cancer recurrence, recent recommendations for cancer survivors from the American Cancer Society (ACS) underscore the growing importance of a healthy diet across the continuum of cancer survivorship. […] As weight gain is a common occurrence following breast cancer diagnosis, and survivors are at increased risk for comorbid conditions such as cardiovascular disease and diabetes, achieving a healthy weight through reductions in caloric intake and increases in energy expenditure through a combination of diet, exercise, and behavioral strategies is encouraged.

• #15 Create a Breast Cancer Recurrence Prevention Plan: Here’s How – UHealth Collective

  https://news.umiamihealth.org/en/create-a-breast-cancer-recurrence-prevention-plan-heres-how/

  There are many things breast cancer survivors can do to reduce their risk of recurrence. […] According to scientific research, breast cancer survivors can do things in their daily lives that help prevent cancer from recurring. […] Studies have shown that anti-estrogen therapies are among the medications that decrease the risk of metastatic recurrence in someone who has already had breast cancer. […] In addition to medical options, lifestyle factors play a big role in preventing breast cancer recurrence, says Dr. Krill-Jackson. […] We know that a low-fat diet in somebody who has had breast cancer decreases the risk of breast cancer recurrence, she says. […] There are other factors that diminish recurrence risk, like exercise and minimizing alcohol. […] The No.1 factor in a breast cancer recurrence prevention plan should be to achieve and maintain a healthy body weight, says Tracy Crane, Ph.D., RDN, director of Lifestyle Medicine, Digital Health and Cancer Prevention at Sylvester.

• #16 Create a Breast Cancer Recurrence Prevention Plan: Here’s How – UHealth Collective

  https://news.umiamihealth.org/en/create-a-breast-cancer-recurrence-prevention-plan-heres-how/

  We know that breast cancer is one of the obesity-related cancers, and higher levels of obesity are related to higher levels of recurrence, says Dr. Crane. […] Quality sleep and meal timing, which promote circadian alignment, may also be important. […] Scientists have found an association between getting quality sleep and meal timing that may help prevent breast cancer recurrence, according to Dr. Crane. […] A nutrition plan that aims to reduce breast cancer recurrence risk should also be heart healthy, according to Federika Garcia, M.S., RDN, LDN, CNSC, a clinical nutrition manager (oncology nutrition) at Sylvester. […] Garcia says these are 5 foundations of a nutrition plan for breast cancer survivors: Lean into plant-based foods. […] Fiber has a role in estrogen reduction and may help with hormone regulation, Garcia says.

• #17 Reducing the Risk of Breast Cancer Recurrence: an Evaluation of the Effects and Mechanisms of Diet and Exercise

  https://pmc.ncbi.nlm.nih.gov/articles/PMC5112289/

  After a median of 60 months, only 9.8 % of women in the diet group had reported a recurrence event compared to 12.4 % of women in the control group, with a hazard ratio for relapse-free survival, defined as recurrence at any site, of 0.76 (95 % CI, 0.60 to 0.98; p=.034). […] The physiological basis for the relationship between a high-fat diet and breast cancer recurrence has been attributed to higher body adiposity and the modulatory effects of dietary fats on eicosanoid synthesis. […] The accumulation of adipose tissue, specifically visceral fat, increases circulating levels of pro-inflammatory cytokines, including interleukin-6 (IL-6) and transforming growth factor beta (TGF-), and the pro-inflammatory adipokine, leptin, which are secreted from the adipose tissue itself. […] In addition to adiposity, dietary fat is postulated to contribute to carcinogenesis through the synthesis of certain eicosanoids or lipid compounds metabolized from fatty acids that support tumor growth.

• #18 Preventing Recurrence – Europa Donna

  https://www.europadonna.org/prevention-and-breast-health/preventing-recurrence/

  The evidence for following a specific diet in order to reduce breast cancer recurrence is not conclusive, although many studies find that a Mediterranean diet that includes fish, olive oil, vegetables is desirable and that processed meat and red meat should be avoided. […] Obesity and BMI studies have shown that women who are obese are more likely to have a breast cancer recurrence and have poorer survival compared to those who maintain a normal body weight BMI less than 25. The effect of breast cancer treatments is lower in women who are obese than it those who are of normal weight.

• #19 Diet, lifestyle and breast cancer recurrence | Breast Cancer Now

  https://breastcancernow.org/about-breast-cancer/life-after-treatment/diet-lifestyle-and-breast-cancer-recurrence

  You may have heard that diet and lifestyle can affect the risk of breast cancer coming back, also known as recurrence. […] The World Cancer Research Fund (WCRF) recommends that people who have had breast cancer follow advice to reduce their risk of cancer coming back. This includes: Eating a healthy diet that is high in fibre and low in saturated fats, Being physically active, Maintaining a healthy weight, Limiting alcohol. […] There is some evidence that fibre may reduce the risk of breast cancer recurrence, but further research is needed to find out more. […] There is some evidence that saturated fat may increase the risk of recurrence, but further research is needed to find out more. […] Current evidence suggests a diet containing naturally occurring phytoestrogens is safe if you’ve had breast cancer and may be beneficial.

• #20 Women’s health

  https://www.mayoclinic.org/healthy-lifestyle/womens-health/in-depth/breast-cancer-prevention/art-20044676

  Breast cancer prevention starts with healthy habits such as limiting alcohol and staying physically active. Learn what you can do to lower your breast cancer risk. […] Research shows that lifestyle changes can lower the chances of getting breast cancer, even in people at high risk. To lower your risk: […] Limit or stay away from alcohol. It’s safest not to drink alcohol. But if you do drink it, enjoy it in moderation. The more alcohol you have, the greater your risk of getting breast cancer. […] Stay at a healthy weight. Ask a member of your health care team whether your weight is healthy. If it is, work to maintain that weight. If you need to lose weight, ask your health care professional how to do so. […] Get active. Physical activity can help you stay at a healthy weight, which helps prevent breast cancer.

• #21 Can I do anything to prevent breast cancer recurrence? | The Royal Marsden

  https://www.royalmarsden.nhs.uk/private-care/news-and-blogs/can-i-do-anything-prevent-breast-cancer-recurrence

  If you have had breast cancer, it is normal to worry about it returning. While there is no way to guarantee you won’t experience recurrence, there are things you can do to reduce your risk. […] Making healthy lifestyle choices is important after breast cancer treatment. Controlling your weight, being physically active, and eating well may lower your risk of breast cancer returning, as well as help protect you from other health problems. […] There is some evidence a diet high in fibre and low in saturated fat can reduce the risk of breast cancer recurrence, though we need more research to prove this. […] The Nurses Health Study found people with low levels of vitamin D have an associated higher risk of breast cancer recurrence. […] There is a link between alcohol consumption and the risk of breast cancer. NICE (National Institute for Health and Care Excellence) recommends limiting your alcohol intake to below five units a week if you’ve had breast cancer.

• #22 Drinking alcohol not likely to increase risk of a breast cancer recurrence – Kaiser Permanente Division of Research

  https://divisionofresearch.kaiserpermanente.org/alcohol-breast-cancer-recurrence/

  A Kaiser Permanente study provides new information that may help oncologists answer one of the most common questions they get from breast cancer survivors: Is it safe for me to drink alcohol? […] The findings suggest drinking alcohol is not associated with an increased risk of having breast cancer come back or dying from the disease. […] For this reason, we thought that drinking alcohol after a breast cancer diagnosis could increase the risk of a cancer recurrence. But our study found that, overall, drinking alcohol after a breast cancer diagnosis does not impact a patients prognosis. […] The researchers determined that, in general, there was no association between alcohol use at the time of a breast cancer diagnosis or 6 months later and the risk of recurrence or death. […] Our study found that, overall, drinking alcohol after a breast cancer diagnosis does not impact a patients prognosis. […] The researchers hope that their findings will help doctors provide accurate information to breast cancer survivors who want to know what lifestyle changes they can make to improve their outcomes.

• #23 Surgery to Reduce the Risk of Breast Cancer Fact Sheet – NCI

  https://www.cancer.gov/types/breast/risk-reducing-surgery-fact-sheet

  Yes. Risk-reducing (also called preventive or prophylactic) surgery can lower the risk of breast cancer in people who are at very high risk, such as women who carry a harmful mutation in a breast cancer susceptibility gene such as BRCA1, BRCA2, TP53, or PTEN. […] The main type of surgery to reduce breast cancer risk is the removal of both breasts, called bilateral risk-reducing mastectomy (or bilateral prophylactic mastectomy). […] Bilateral mastectomy has been shown to reduce the risk of breast cancer by at least 95% in women who have a harmful (disease-causing) variant in the BRCA1 gene or the BRCA2 gene and up to 90% in women who have a strong family history of breast cancer. […] People who are known to have inherited a harmful mutation that greatly increases their risk of developing breast cancer may consider having bilateral risk-reducing mastectomy to reduce this risk.

• #24 Surgery to Reduce the Risk of Breast Cancer Fact Sheet – NCI

  https://www.cancer.gov/types/breast/risk-reducing-surgery-fact-sheet

  Yes. Some people who have been diagnosed with cancer in one breast, particularly those who are known to be at very high risk, may consider having the other breast (called the contralateral breast) removed as well, even if there is no sign of cancer in that breast. Removal of the contralateral breast during breast cancer surgery (known as contralateral prophylactic mastectomy) reduces the risk of breast cancer in that breast. […] People with a harmful BRCA variant who have surgery to treat breast cancer may also consider having risk-reducing salpingo-oophorectomy to improve their long-term outcomes. […] Options for some people who are at very high risk of breast cancer (or of contralateral breast cancer, if they have previously been treated for breast cancer) and wish to avoid risk-reducing surgery include: Risk-reducing medications (sometimes called chemoprevention). Tamoxifen and raloxifene are approved by the U.S. Food and Drug Administration (FDA) to reduce breast cancer risk in women who, based on their personal and family medical history, have an increased risk of breast cancer. […] However, tamoxifen may lower the risk of contralateral breast cancer among BRCA1 and BRCA2 variant carriers previously diagnosed with breast cancer.

• #25 Can I do anything to prevent breast cancer recurrence? | The Royal Marsden

  https://www.royalmarsden.nhs.uk/private-care/news-and-blogs/can-i-do-anything-prevent-breast-cancer-recurrence

  Regular exercise may reduce the risk of breast cancer returning. Maintaining a healthy weight is also key, as people who are overweight have a higher risk of breast cancer recurrence. […] Attend your annual imaging and surveillance appointments to keep an eye on the health of your breasts after breast cancer. These follow-up appointments and screenings will improve the chances of finding cancer should it return. Taking your medications as prescribed will also reduce the risk of your cancer returning. […] If you’ve had a lateral (one-sided) mastectomy, you greatly reduce your chances of recurrent breast cancer in that breast. A bilateral mastectomy removes almost all of your breast tissue, which significantly reduces the risk of breast cancer recurrence. […] A mastectomy also can’t prevent cancer recurrence in other parts of your body.

• #26 Fear of breast cancer recurrence prompting women to choose prophylactic mastectomy – Harvard Health

  https://www.health.harvard.edu/blog/fear-of-breast-cancer-recurrence-prompting-women-to-choose-prophylactic-mastectomy-201212055619

  Living through the physical and emotional toll of breast cancer is so traumatic that some women cant bear the thought of doing it again. […] A University of Michigan study presented last week at the American Society of Clinical Oncologys Quality Care Symposium showed that nearly three-quarters of women who had this procedure were actually at very low risk of developing cancer in the healthy breast. […] The new study suggests that more and better information about breast cancer recurrence and the risks and benefits of prophylactic mastectomy are needed as women consider this procedure. […] Fear seems to be one of the main drivers of this increase. […] The average woman diagnosed with cancer in one breast has a less than 1% risk of developing cancer in the second breast. […] Its also important to keep in mind that prophylactic mastectomy wont guarantee a cancer-free future.

• #27 How to Prevent Cancer Recurrence | American Cancer Society

  https://www.cancer.org/cancer/survivorship/long-term-health-concerns/recurrence/can-i-do-anything-to-prevent-cancer-recurrence.html

  Eating right, exercising, and seeing your cancer care team for follow-up visits are helpful ways to try to reduce your risk, but these efforts cannot completely keep cancer from recurring. […] Keeping a healthy weight may help to lower the risks of cancer recurrence. […] Research has not yet shown if physical activity can help prevent cancer recurrence or slow the growth of disease. […] There’s no way to guarantee that once you have completed cancer treatment the cancer will never come back. […] Whenever you have a symptom, your first thought might be that your cancer has come back. Remember that there are illnesses and medical problems that have nothing to do with your previous cancer. […] Some people find it very hard to not worry about cancer coming back and these thoughts interfere with daily life.

• #28

  http://www.bccancer.bc.ca/books/breast/follow-up/detecting-recurrences

  The follow-up of patients who have been treated with curative intent for breast cancer has four main goals: […] All patients who have undergone curative treatment for breast cancer should be seen by a physician every 6 months until 5 years from diagnosis, then annually for a careful history and physical examination including examination of the nodal regions of the head, neck and axilla, breast/chest wall, heart, lung, spine, and abdomen. […] Regular history and physical examination plus annual mammography should aid in early detection of local, regional, or distant metastases. […] A new primary malignancy in the contralateral breast occurs at a rate of approximately 0.5% to 1% per year. […] Adjuvant hormone therapy will reduce this risk. […] Patients taking hormone therapy are typically advised to take hormone therapy for 5-10 years after initial treatment. […] Long-term side effects may occur as a result of any part of management of breast cancer.

• #29 Patient education – Breast Cancer – UF Health

  https://ufhealth.org/conditions-and-treatments/breast-cancer/patient-education

  Monthly breast self examinations and annual clinical exams and mammograms in women 50 years and older could prevent as many as 30 percent of those deaths. […] Women with LCIS should pay close attention to having regular mammograms. […] Women at increased risk (for example, family history, genetic tendency, past breast cancer) should talk with their doctors about the benefits and limitations of starting mammography screening earlier, having additional tests (for example, breast ultrasound or MRI) or having more frequent exams. […] The High Risk Program at the UF Breast Center not only identifies women at a higher risk level but also provides individualized preventive care to reduce that risk. […] Individualized risk assessment and creation of a unique plan, which may include: Digital mammography, Breast MRI, Genetic counseling and testing, Chemoprevention, Lifestyle modification, Risk-reducing surgery and reconstruction. […] Prophylactic mastectomy with immediate reconstruction for high risk women.

• #30 Risk Factors and Prevention of Recurrence, Living with Breast Cancer, CBCN

  https://www.cbcn.ca/en/recurrence-prevention

  Anyone who has been diagnosed with breast cancer and is in remission can have a recurrence. A persons risk of a breast cancer recurrence depends on a variety of factors: […] Being diagnosed with breast cancer before age 35 increase a persons chance to have a breast cancer recurrence. […] The stage of the original cancer that an individual is diagnosed with impacts the likelihood of a recurrence. Breast cancer stage is determined by a variety of factors, including tumor size and cancer that involves the lymph nodes. People with larger tumors have a higher risk of a recurrence. Cancers found near the lymph nodes have a greater risk of returning. If the original cancer didnt involve the axillary lymph nodes, there is a 6% chance of a cancer recurrence. If the original cancer did involve the axillary lymph nodes, the chance of a breast cancer recurrence increases to 25% but drops to 6% with radiation therapy after a mastectomy.

• #31 Risk Factors and Prevention of Recurrence, Living with Breast Cancer, CBCN

  https://www.cbcn.ca/en/recurrence-prevention

  Inflammatory breast cancers and triple-negative breast cancers are harder to treat and are more likely to come recur and spread. […] If there are positive margins or the margin between the tumor and normal tissue are close, there is an increased risk of a breast cancer recurrence. […] A local breast cancer recurrence can occur within 5 years of treatment. Individuals who have radiation therapy following a lumpectomy have a reduced risk of a recurrence, similar to the risk of recurrence following a mastectomy. Those who have a lumpectomy and radiation therapy have a 3% to 15% chance of having a recurrence within 10 years. Having chemotherapy for people with an increased risk of recurrence can reduce that risk. If the original cancer is HR-positive, receiving hormone therapy (also known as endocrine therapy) following treatment may reduce the risk of a recurrence. If the original cancer is HER2-positive, targeted therapy can decrease the risk of a recurrence.

• #32 Adherence to Cancer Prevention Lifestyle Recommendations Before, During, and After Treatment for High-Risk Breast Cancer Association With Recurrence and Mortality – The ASCO Post

  https://ascopost.com/news/june-2023/adherence-to-cancer-prevention-lifestyle-recommendations-before-during-and-after-treatment-for-high-risk-breast-cancer-association-with-recurrence-and-mortality/

  In a study reported in JAMA Network Open, Cannioto et al found that greater adherence to cancer prevention lifestyle recommendations before, during, and after treatment for high-risk breast cancer was associated with a reduced risk of disease recurrence and all-cause mortality. […] The investigators concluded, In this observational study of patients with high-risk breast cancer, strongest collective adherence to cancer prevention lifestyle recommendations was associated with significant reductions in disease recurrence and mortality. Education and implementation strategies to help patients adhere to cancer prevention recommendations throughout the cancer care continuum may be warranted in breast cancer.

• #33 Treatments for recurrent breast cancer | Canadian Cancer Society

  https://cancer.ca/en/cancer-information/cancer-types/breast/treatment/recurrent

  Breast cancer can come back (recur) after treatment. Sometimes it recurs years after it was first treated. There are different types of recurrence. […] When deciding which treatments to offer for recurrent breast cancer, your healthcare team will consider: if it is a local, regional or distant recurrence, the type and number of treatments you have had for breast cancer, the hormone receptor status of the cancer, the HER2 status of the cancer, any other genetic changes to the cancer cells, your overall health, any medical problems you have, your lifestyle and what you prefer or want. […] Hormone therapy is often offered for a local recurrence of hormone receptor-positive breast cancer. […] Chemotherapy may be offered for locally recurrent breast cancer to reduce the risk of the cancer coming back again.

• #34 Breast Cancer Recurrence: Symptoms, Causes, and Prognosis

  https://www.verywellhealth.com/breast-cancer-recurrence-3576787

  Tamoxifen, a drug approved for breast cancer risk reduction, can lower the incidence of invasive, ER-positive breast cancer in high-risk women. Aromatase inhibitors have also been proven to help prevent breast cancer recurrence. […] Even if you do everything „right,” breast cancer can still return. Arguably the best strategy is to identify a recurrence early, when treatment is expected to be most effective. This involves keeping your appointments, having routine mammograms, and staying linked to care with a medical team that knows your history. […] Maintain a healthy lifestyle by eating right, exercising regularly, cutting back on alcohol, and losing weight (if needed) to help lower your overall risk. […] Clinical trials are currently in place looking at therapies such as daily low dose aspirin and melatonin to reduce recurrence risk, but it’s not known if these treatments will be effective.

• #35 Could blocking a protein stop breast cancer from recurring?

  https://www.medicalnewstoday.com/articles/metastatic-breast-cancer-scientists-find-new-mechanism-to-prevent-recurrence

  Patients with estrogen receptor (ER)-positive breast cancer are at risk of cancer recurrence even decades after treatment. […] A new study found that disseminated cancer cells remain dormant in the lungs of young, healthy mice, but in older mice or mice with lung damage, they grow rapidly to form tumors. […] These findings suggest that blocking PDGF-C using a drug could potentially prevent cancer recurrence in patients with ER-positive breast cancer. […] In mice with aging or damaged lungs, disseminated cancer cells rapidly grew into large tumors. […] Based on their findings, Professor Isacke and her coworkers concluded that, in aging or damaged lungs, high levels of PDGF-C create an environment that promotes the growth of lung tumors. […] Since imatinib is already used to treat chronic myeloid leukemia in both old and young patients and is well-tolerated, it presents a promising route to prevent cancer recurrence in ER-positive breast cancer patients.

• #36 Does Daily Aspirin Help Prevent Breast Cancer Recurrence? – The ASCO Post

  https://ascopost.com/news/february-2022/does-daily-aspirin-help-prevent-breast-cancer-recurrence/

  Taking aspirin daily does not prevent breast cancer recurrence, according to research presented by Wendy Y. Chen, MD, MPH, a medical oncologist at Dana-Farber Cancer Institute, during the February 2022 ASCO Plenary Series session (Abstract 360922). […] Although inflammation may still play a role in cancer progression, aspirin is not recommended for prevention of breast cancer recurrence, said lead author Dr. Chen. […] These data showed no benefit of [300 mg of] aspirin daily in terms of breast cancer invasive diseasefree survival, said Dr. Chen.

• #37

  https://www.healio.com/news/hematology-oncology/20240429/disappointing-data-confirm-aspirin-does-not-reduce-risk-for-breast-cancer-relapse

  Daily aspirin use did not reduce breast cancer recurrence. […] Patients with history of early breast cancer should not be encouraged to take aspirin routinely to improve their breast cancer outcomes, Wendy Y. Chen, MD, senior physician and assistant professor at Dana-Farber Cancer Institute, told Healio. […] The study showed no benefit to aspirin among breast cancer survivors, Chen said. These were disappointing results and not what we were expecting. […] Aspirin’s impact on other cancers should still be researched.

• #38 Could blocking a protein stop breast cancer from recurring?

  https://www.medicalnewstoday.com/articles/metastatic-breast-cancer-scientists-find-new-mechanism-to-prevent-recurrence

  We now plan to better unpick how patients might benefit from the existing drug imatinib, and in the long term aim to create more specific treatments targeted at the reawakening mechanism. […] Next we need to pinpoint when these age-related changes happen and how they vary between people so that we can create treatment strategies that prevent cancer cells reawakening.

• #39 Researchers discover promising approach to prevent recurrence of breast cancer – ecancer

  https://ecancer.org/en/news/24890-researchers-discover-promising-approach-to-prevent-recurrence-of-breast-cancer

  Researchers discover promising approach to prevent recurrence of breast cancer. […] A particular challenge in breast cancer treatment is the recurrence of the disease. […] The reasons why dormant breast cancer cells awake even after several years are not well understood. However, identifying these reasons could provide an opportunity to develop new therapies to prevent cancer recurrence. […] Based on our findings, blocking the DUSP6 protein could therefore provide a basis for effective combination therapy also in HER2 breast cancer cases that have already lost response to treatment. […] Importantly, the drug was shown to significantly enhance the therapeutic effect of several existing HER2 inhibitors. […] These newly-published basic research results provide important evidence that DUSP6 is a very promising target protein for future cancer drug development and worth investigating.

• #40 Long-Term Follow-Up Supports Anastrozole Treatment to Prevent Breast Cancer Recurrence

  https://www.cancernetwork.com/view/long-term-follow-supports-anastrozole-treatment-prevent-breast-cancer-recurrence

  Five years of treatment with anastrozole safely and effectively prevented breast cancer recurrence in high-risk postmenopausal women at 10.9 years of follow-up. […] These data provide further support for the use of anastrozole in breast cancer prevention in high-risk women. […] After the 10.9-year follow-up, women’s chance of having their breast cancer recur was reduced by 50%, compared with those who received placebo. […] Moreover, invasive estrogen receptor (ER)-positive breast cancer was reduced by 54%, with a continued significant effect in the period after treatment. […] This highlights the need, particularly in prevention studies, for long-term follow-up.

• #41 Breast Cancer Recurrence Prevention | All Seniors Foundation

  https://allseniors.org/cancer-care/breast-cancer/support-for-breast-cancer/breast-cancer-recurrence-prevention/

  For many breast cancer survivors, finishing active treatment is an important milestone—yet concerns about the cancer’s return can linger. Preventing recurrence becomes a primary goal, shaped by each patient’s unique medical history, tumor characteristics, and personal choices. […] By recognizing these aspects and taking proactive action, survivors enhance the likelihood of long-term remission and stability. […] Medical teams customize post-treatment care to eradicate lingering cancer cells and avert relapse. Key measures include: […] Though adjuvant therapy can be physically demanding, it offers a powerful hedge against recurrence, with balanced protocols for older patients or multi-illness survivors safeguarding comfort and function. […] For hormone receptor-positive cancers, blocking estrogen or progesterone signals over several years significantly decreases relapse: […] Given that hormone treatment can last 5–10 years, older adults—especially those with osteoporosis or heart problems—should coordinate with specialists to keep side effects manageable, protecting both bones and cardiovascular health.

• #42 Breast Cancer Recurrence Prevention | All Seniors Foundation

  https://allseniors.org/cancer-care/breast-cancer/support-for-breast-cancer/breast-cancer-recurrence-prevention/

  Healthy BMI Range: Postmenopausal obesity correlates with higher recurrence, especially in hormone receptor-positive breast cancer. […] Weight management also reduces stress on the heart, joints, and other systems—critical for older survivors balancing multiple conditions. […] Prolonged stress can weaken immune surveillance, potentially giving dormant cancer cells a chance to proliferate. Methods to manage stress include: […] Combining emotional care with physical health efforts yields synergy: calmer individuals often maintain better adherence to medical advice and healthy habits, reinforcing a cycle of positive outcomes. […] Adjuvant therapies, such as hormone blockers, can persist for years beyond active treatment. Consistent medication intake is vital to sustain protective benefits: […] Older adults might also schedule medication reviews with geriatricians, guaranteeing that no unnecessary or conflicting drugs hamper cancer prevention or daily comfort.

• #43 Reducing the Risk of Breast Cancer Recurrence

  https://www.verywellhealth.com/reducing-breast-cancer-recurrence-4688612

  According to a 2017 study, cisgender women who experience regular sleep difficulties, as well as those who have a prolonged sleep duration (defined as nine or more hours vs. eight hours of sleep) have a greater all-cause as well as breast cancer mortality rate. […] It’s now known that alcohol can increase the risk of breast cancer, and even moderate amounts of alcohol may raise the risk of recurrence. […] It’s long been suspected that environmental exposures, including the chemicals we are exposed to in everything from household cleaners to cosmetics, may play a role both in breast cancer risk and recurrence. […] The potential for breast cancer to recur is frightening, and knowing that there are at least a few things you can do yourself (in addition to using medications prescribed by your oncologist) can sometimes help you feel empowered in your journey.

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