Materiały źródłowe

• #1 Recognizing and Managing Recurrent Breast Cancer: Signs and Treatment Options

  https://aocancer.com/blog/recognizing-and-managing-recurrent-breast-cancer-signs-and-treatment-options

  Breast cancer is often successfully treated, especially when it is detected early. That fact remains, however, breast cancer returns for some patients after the initial treatment plan is complete. This is what is known as recurrent breast cancer. […] Your cancer care team will develop a new treatment plan based on the type of recurrence and extent of cancer when its found. […] Your treatment plan is influenced by many factors, especially cancers location and the treatments youve had previously. For example, if you had radiation therapy previously, it is unlikely your oncologist will suggest that type of treatment again. Here is what to expect for local, regional, or distant breast cancer recurrence. […] Mastectomy (breast removal) might be the suggested treatment if your initial surgery was a lumpectomy to preserve the breast. Additionally, nearby lymph nodes will be removed if they werent already done so in the first surgery.

• #2 Recurrent breast cancer – Symptoms and causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/recurrent-breast-cancer/symptoms-causes/syc-20377135

  Recurrent breast cancer is breast cancer that comes back after initial treatment. Although the initial treatment is aimed at eliminating all cancer cells, a few may have evaded treatment and survived. These undetected cancer cells multiply, becoming recurrent breast cancer. […] Learning you have recurrent breast cancer may be harder than dealing with the initial diagnosis. But having recurrent breast cancer is far from hopeless. Treatment may eliminate local, regional or distant recurrent breast cancer. Even if a cure isn’t possible, treatment may control the disease for long periods of time. […] The chemotherapy, radiation, hormone therapy or other treatment you may have received after your first breast cancer diagnosis was intended to kill any cancer cells that may have remained after surgery. But sometimes these treatments aren’t able to kill all of the cancer cells.

• #3 Breast cancer recurrence rates: Types and outlook

  https://www.medicalnewstoday.com/articles/breast-cancer-types-recurrence-rates

  The risk of breast cancer recurrence varies depending on the type of breast cancer, the stage of the cancer at diagnosis, and the persons age and health. Inflammatory breast cancer and triple-negative breast cancer have the highest recurrence rates. […] After treatment, some people may experience breast cancer recurrence, which is the return of cancer cells in the breast or nearby areas. […] Breast cancer recurrence is when breast cancer returns or recurs after treatment. It can occur in the same breast, lymph nodes under the arm, or other parts of the body. […] All types of breast cancer can recur, but aggressive subtypes, such as inflammatory breast cancer (IBC) and triple-negative breast cancer (TNBC), are more likely to return. […] IBC has a 50% chance of recurring in the same area of the breast it was initially.

• #4 How are Treatments Different for Recurrent Breast Cancer?

  https://www.cancercarebrevard.com/blog/how-are-treatments-different-for-recurrent-breast-cancer

  Breast cancer that returns after treatment has been completed is called recurrent breast cancer. If it comes back, its most likely to happen one to three years after cancer treatment. Recurring breast cancers can be aggressive and difficult to treat. […] Treatment for recurrent breast cancer is typically different from your initial breast cancer treatment. […] Cancer recurrence is usually caused by cancer cells that werent destroyed or killed by your initial treatments and start growing rapidly. […] Recurrence can also be caused by cells from your original cancer that separated from the tumor but stayed dormant. […] There are several factors that can increase the risk of recurrent breast cancer. […] The risk of recurrence also increases if you smoke, are overweight, dont get regular physical activity, and have poor overall health.

• #5 Breast cancer recurrence | Breast Cancer Now

  https://breastcancernow.org/about-breast-cancer/diagnosis/breast-cancer-recurrence/

  After treatment, most breast cancers dont come back. But sometimes breast cancer can return. […] Recurrence is the term used when breast cancer has come back. […] There are 3 different types of breast cancer recurrence depending on where in the body the cancer has returned. […] Treatment for local recurrence will depend on a number of factors, including what treatments youve had previously. […] If you had breast-conserving surgery then youll usually be offered a mastectomy. For some people it may be possible to repeat the wide local excision. […] If the cancer is oestrogen receptor positive you may be offered hormone therapy. […] Its not clear how much benefit chemotherapy will be if you have a local recurrence, but it might be offered in some cases. […] This is likely to include a treatment that affects the whole body (systemic treatment).

• #6 Breast cancer recurrence | Macmillan Cancer Support

  https://www.macmillan.org.uk/cancer-information-and-support/breast-cancer/breast-cancer-recurrence

  Breast cancer that comes back is called a recurrence. There are different types of recurrence. Breast cancer may come back in the area where it started or in an area nearby such as the lymph nodes in the collarbone or another part of the body. […] If it comes back in a different part of the body, for example the bones, it is known as secondary breast cancer. […] Sometimes breast cancer comes back in the treated breast or the scar. This is called a local recurrence. […] Sometimes breast cancer comes back in the lymph nodes in the armpit, close to the breastbone or in the lower neck. This is called a regional recurrence. […] A local or regional breast cancer recurrence can occur on its own or at the same time as secondary breast cancer. […] Your treatment will depend on the treatment you have already had for breast cancer. Your doctor and nurse will talk to you about the most effective treatment for you.

• #7 Breast Cancer Recurrence: Types, Symptoms and Risk

  https://www.cancercenter.com/cancer-types/breast-cancer/types/rare-breast-cancer-types/recurrent-breast-cancer

  Even after initial treatment is complete and tests show no sign of disease, there is a chance breast cancer may return. When that happens, its called recurrent breast cancer. […] Treatment of breast cancer depends on where the cancer has recurred and what breast cancer treatment the patient has had before: […] Local recurrence is likely to be treated surgically first with a mastectomy if the patient didnt have one already or a surgical removal of the tumor if she did. After surgery, breast cancer chemotherapy and radiation are commonly used, as well as hormone therapy or targeted therapy if the specific type of cancer will respond to one or both of them. […] Regional recurrence is also typically treated first with surgery to remove affected lymph nodes. After the surgery, the patient will likely have radiation and possibly chemotherapy, hormone therapy and/or targeted therapy, too. […] Distant recurrence is mainly treated with drug therapychemotherapy, hormone therapy, targeted therapy for breast cancer or a combination of these. Breast cancer surgery and/or radiation might be used, too, but only in cases where the aim is relieving symptoms.

• #8 Treatments for recurrent breast cancer | Canadian Cancer Society

  https://cancer.ca/en/cancer-information/cancer-types/breast/treatment/recurrent

  Breast cancer can come back (recur) after treatment. Sometimes it recurs years after it was first treated. There are different types of recurrence. […] When deciding which treatments to offer for recurrent breast cancer, your healthcare team will consider: if it is a local, regional or distant recurrence, the type and number of treatments you have had for breast cancer, the hormone receptor status of the cancer, the HER2 status of the cancer, any other genetic changes to the cancer cells, your overall health, any medical problems you have, your lifestyle and what you prefer or want. […] The following treatments may be offered for locally recurrent breast cancer. […] Surgery is offered for a local recurrence of breast cancer. The type of surgery done will depend on the kind of surgery that you had to treat the original breast cancer.

• #9 Multidisciplinary Management of Locoregional Recurrent Breast Cancer

  https://pmc.ncbi.nlm.nih.gov/articles/PMC8462537/

  Locoregional recurrence (LRR) from breast cancer represents a heterogeneous class of disease that has significant variation in its prognosis and preferred treatments. Therefore, the optimal management of LRR disease requires multidisciplinary assessment and integration of input from all disciplines involved in breast cancer management. […] Unfortunately, there are few prospective clinical trials to provide high-level evidence regarding the optimal therapeutic strategy for patients with LRR disease. Such trials are difficult to design and execute because of the heterogeneity of prognostic factors and previous treatments of patients. […] All patients with LRR should undergo biopsy to establish the diagnosis and evaluate the biomarkers of the recurrent disease. In addition, all patients should undergo staging studies to rule out the presence of distant metastases. Patients who are found to have synchronous distant metastases with the LRR should be treated in an analogous fashion to patients with stage IV breast cancer, with the exception that they may require palliative radiation should the LRR become symptomatic. For patients with isolated LRR, we favor a more aggressive strategy of multimodality therapy that attempts to eradicate all sites of disease for potential cure.

• #10 Recurrent breast cancer – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/recurrent-breast-cancer/diagnosis-treatment/drc-20377141

  If your doctor suspects you may have recurrent breast cancer based on results of a mammogram or physical exam, or because of signs and symptoms, he or she may recommend additional tests to confirm the diagnosis. […] Your treatment options will depend on several factors, including the extent of the disease, its hormone receptor status, the type of treatment you received for your first breast cancer and your overall health. Your doctor also considers your goals and your preferences for treatment. […] Treatment for a local recurrence typically starts with an operation and may include radiation if you haven’t had it before. Chemotherapy and hormone therapy also may be recommended. […] For recurrent breast cancer that’s confined to the breast, treatment usually involves removing any remaining breast tissue.

• #11 :: Journal of Breast Disease

  https://www.jbd.or.kr/m/journal/view.php?number=158

  Locoregional recurrence (LRR) in breast cancer poses significant challenges due to its association with biologically resistant disease and a high likelihood of concurrent occult systemic disease. […] Therefore, a comprehensive review of systemic treatment strategies following LRR is warranted to address the gaps in our understanding and improve patient outcomes. […] To improve the prognosis of patients with breast cancer LRR, a combination of systemic and local treatment options has been proposed. […] Established standards or clinical study results to guide systemic treatment in these patients are very limited. […] This review aimed to summarize the factors influencing prognosis in breast cancer LRR, review randomized controlled trials (RCTs) assessing the benefits of systemic treatment following LRR resection, and explore systemic treatment strategies for the management of breast cancer LRR.

• #11 :: Journal of Breast Disease

  https://www.jbd.or.kr/m/journal/view.php?number=158

  The prognosis of LRR is poor. Approximately 50% of patients develop additional recurrent disease, and 30%60% of patients die from metastatic disease within 5 years of recurrence. […] The CALOR trial has highlighted the benefits of adjuvant chemotherapy in improving prognosis for patients with ER-negative LRR. […] However, the benefit of chemotherapy for ER-positive LRR remains unclear and should be individualized based on patient-specific factors. […] For patients with ER-negative breast cancer LRR, aggressive chemotherapy may be of benefit. […] In contrast, patients with ER-positive LRR lesions may require modifications to their endocrine therapy or the addition of CDK 4/6 inhibitors to enhance outcomes. […] For unresectable LRR, initial systemic therapy to reduce tumor size and enhance resectability, followed by potential surgical intervention, is recommended. […] Future studies should focus on developing more precise predictive models to identify patients at high risk of distant metastases and tailor systemic treatment accordingly.

• #12 Treatment of Recurrent Breast Cancer | American Cancer Society

  https://www.cancer.org/cancer/types/breast-cancer/treatment/treatment-of-breast-cancer-by-stage/treatment-of-recurrent-breast-cancer.html

  For some women, breast cancer may come back after treatment sometimes years later. This is called a recurrence. Recurrence can be local (in the same breast or in the surgery scar), regional (in nearby lymph nodes), or in a distant area. […] For women whose breast cancer has recurred locally, treatment depends on their initial treatment. If you had breast-conserving surgery (lumpectomy), a local recurrence in the breast is usually treated with mastectomy. If the initial treatment was mastectomy, recurrence near the mastectomy site is treated by removing the tumor whenever possible. This is often followed by radiation therapy if not given before. In either case, hormone therapy, targeted therapy (like trastuzumab), immunotherapy, chemotherapy, or some combination of these may be used after surgery and/or radiation therapy. These drugs might also be used if surgery or radiation are not options.

• #13 Understanding Breast Cancer Recurrence

  https://www.oregoncancer.com/breast-cancer/recurrence

  Surgery is typically the first step in treating local recurrence. This would involve a mastectomy for women who initially had a lumpectomy. If a mastectomy was performed previously, the new tumor along with some nearby lymph nodes and a margin of healthy tissue will be surgically removed. Following surgery, radiation therapy might be administered if it wasn’t part of the initial treatment plan. Other possible treatments for local breast cancer recurrence include: Hormone Therapy: Medications that block estrogen and progesterone may be effective in preventing cancer cell growth for hormone-receptor-positive cancer. […] Regional recurrence indicates a tumor has developed and spread to nearby lymph nodes. In this case, surgery will involve removing the affected lymph nodes along with the cancer. After surgery, some patients may receive radiation therapy to eliminate any residual cancer cells. Systemic therapies, such as hormone therapy, chemotherapy, or targeted therapy, may also be administered to destroy any remaining cancer cells after surgery.

• #14 Treatments for recurrent breast cancer | Canadian Cancer Society

  https://cancer.ca/en/cancer-information/cancer-types/breast/treatment/recurrent

  External radiation therapy may be given after surgery to remove a local recurrence if you weren’t given radiation when the cancer was first treated or if the radiation was given many years ago. […] Hormone therapy is often offered for a local recurrence of hormone receptor-positive breast cancer. […] Chemotherapy may be offered for locally recurrent breast cancer to reduce the risk of the cancer coming back again. […] Targeted therapy is often offered for a local recurrence of HER2-positive breast cancer. […] The following treatments may be offered for regionally recurrent breast cancer. […] Surgery is offered for a regional recurrence of breast cancer to remove the lymph nodes where the cancer has recurred. […] External radiation therapy may be given after surgery to remove a regional recurrence if you weren’t given radiation when the cancer was first treated or if the radiation was given many years ago.

• #15 Will Radiation Therapy Protect Me from Breast Cancer Recurrence after Surgery? What to Know | Memorial Sloan Kettering Cancer Center

  https://www.mskcc.org/news/will-radiation-therapy-protect-me-breast-cancer-recurrence-after-surgery-what-know

  Radiation therapy given after breast-conserving surgery (lumpectomy) has proven effective at preventing the cancer from coming back. […] Breast-conserving surgery is usually followed by radiation treatments to destroy any remaining cancer cells in the breast and surrounding lymph nodes. […] Studies over the past 30 years have shown that a lumpectomy followed by radiation therapy in women with stage I or II breast cancer is likely to be as effective as a mastectomy at preventing the disease from coming back (recurrence). […] Women who opt for breast-conserving surgery also have a choice about the type of radiation therapy they receive. […] In December 2019, two large studies published in The Lancet suggested that APBI after a lumpectomy is appropriate for many women with early-stage breast cancer.

• #16 Breast Cancer Treatment | AAFP

  https://www.aafp.org/pubs/afp/issues/2021/0800/p171.html

  For locally recurrent breast cancer initially treated with breast conserving therapy (i.e., lumpectomy plus radiation), further radiation is not recommended; total mastectomy is the standard of care. […] The treatment of recurrent breast cancer requires a multi-disciplinary approach that considers all potential options for optimal outcomes. […] Local recurrence following a mastectomy usually involves the chest wall and requires wide local excision. If the patient did not previously receive radiation, surgical resection followed by radiation therapy is recommended. […] For regional recurrence involving the axillary lymph nodes, surgical resection and radiation therapy are recommended. Radiation therapy without surgery is the standard of care for supraclavicular or internal mammary node recurrence.

• #17 Recurrent breast cancer – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/recurrent-breast-cancer/diagnosis-treatment/drc-20377141

  Radiation therapy uses high-energy beams, such as X-rays or protons, to kill cancer cells. […] Chemotherapy uses drugs to kill cancer cells. Your doctor may recommend chemotherapy after surgery to reduce your risk of another cancer recurrence. […] Medications that block the growth-promoting effects of the hormones estrogen and progesterone may be recommended if your cancer is hormone receptor positive. […] If it’s possible, surgery to remove the cancer is the recommended treatment for a regional recurrence. […] Many treatments exist for metastatic breast cancer. Your options will depend on where your cancer has spread. […] In general, the goal of treatment for metastatic breast cancer isn’t to cure the disease. Treatment may allow you to live longer and can help relieve symptoms the cancer is causing.

• #18 Recognizing and Managing Recurrent Breast Cancer: Signs and Treatment Options

  https://aocancer.com/blog/recognizing-and-managing-recurrent-breast-cancer-signs-and-treatment-options

  Hormone therapy, targeted therapy, immunotherapy, chemotherapy, or a combination of these treatments may be recommended after surgery and/or radiation. Typically, hormone therapy is suggested first if surgery or radiation is not an option. […] Surgery, such as a lumpectomy or mastectomy, is typically the most common course of treatment and is used to remove the cancer and nearby lymph nodes if not already done so with the first surgery. […] Drug treatments, such as chemotherapy, targeted therapy, or hormone therapy, may be suggested as the treatment for regional recurrent cancer. Sometimes it is recommended following surgery or radiation therapy. […] Hormone therapy is usually the first treatment if your cancer is hormone receptor-positive. This treatment has fewer side effects than chemotherapy.

• #19 Current Strategies for the Management of Locoregional Breast Cancer Recurrence – PubMed

  https://pubmed.ncbi.nlm.nih.gov/30731014/

  Advances in the treatment of breast cancer have decreased the rate of isolated locoregional recurrences (ILRRs) over time. Surgery, radiation therapy, and systemic therapies are used to manage these failure events and their associated poor prognosis. Operable ipsilateral breast tumor recurrences (IBTRs) are treated by either salvage mastectomy or, in select cases, repeat lumpectomy. Axillary nodal recurrences and postmastectomy chest wall relapses are commonly amenable to surgical resection, too. […] Adjuvant radiation is recommended for most ILRR cases; the dose and volume must be adjusted for prior to receipt of therapy. Implementation of adjuvant systemic therapies after ILRR should be based on the expression of molecular markers in the recurrent tumor. Administration of chemotherapy for estrogen receptor-negative ILRR is indicated, since it significantly decreases the rate of distant metastases.

• #20 Treatment of Recurrent Breast Cancer | American Cancer Society

  https://www.cancer.org/cancer/types/breast-cancer/treatment/treatment-of-breast-cancer-by-stage/treatment-of-recurrent-breast-cancer.html

  When breast cancer comes back in nearby lymph nodes (such as those under the arm or around the collar bone), it is treated by removing those lymph nodes, if possible. This may be followed by radiation aimed at the area if it was not given before. Systemic treatment (such as chemo, targeted therapy, or hormone therapy) may be considered after surgery as well. […] In general, women whose breast cancer comes back in other parts of the body, such as the bones, lungs, or brain, are treated the same way as those found to have stage IV breast cancer in these organs when they were first diagnosed. Recurrent breast cancer can sometimes be hard to treat. If you are in otherwise good health, you might want to think about taking part in a clinical trial testing a newer treatment.

• #21 Treatments for recurrent breast cancer | Canadian Cancer Society

  https://cancer.ca/en/cancer-information/cancer-types/breast/treatment/recurrent

  Hormone therapy is often offered for a regional recurrence of hormone receptor-positive breast cancer. […] Chemotherapy may be offered for regionally recurrent breast cancer to reduce the risk of the cancer coming back again. […] Distant recurrence of breast cancer is treated like metastatic breast cancer.

• #22 Recurrent Breast Cancer

  https://www.texasoncology.com/types-of-cancer/breast-cancer/recurrent-breast-cancer

  The potential benefits of multi-modality care, participation in a clinical trial, or standard treatment must be carefully balanced with the potential risks. […] Local recurrence of breast cancer following initial treatment with mastectomy may be effectively controlled with additional radiation treatment. […] Despite effective local control with surgery and radiation, the majority of patients experiencing a local recurrence ultimately develop systemic recurrence of their cancer. […] For this reason, many doctors believe additional treatment with chemotherapy or hormonal therapy may be useful. […] A recurrence following breast-conserving therapy that is limited to the local-regional area around the original cancer is typically treated with a mastectomy. […] Patients with regionally recurrent breast cancer are at a higher risk of a future systemic relapse and may benefit most from the addition of radiation therapy or another treatment.

• #23 Breast cancer recurrence | Breast Cancer Now

  https://breastcancernow.org/about-breast-cancer/diagnosis/breast-cancer-recurrence/

  If breast cancer has spread to another part of the body, it can be treated but it cannot be cured. […] The aim of treatment for secondary breast cancer is to control and slow down the spread of the cancer, relieve symptoms, maintain health and wellbeing, and give you the best quality of life for as long as possible. […] Local recurrence can often be successfully treated, particularly if it has been a long time since you first had treatment. […] If youre diagnosed with locally advanced breast cancer, there may be an increased risk of cancer cells spreading to other areas of the body. […] If cancer has spread from the breast to another part of the body, it can be treated but it cannot be cured.

• #24 Recurrent breast cancer – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/recurrent-breast-cancer/diagnosis-treatment/drc-20377141

  If your cancer is hormone receptor positive, you may benefit from hormone therapy. […] Your doctor may recommend chemotherapy if your cancer is hormone receptor negative or if hormone therapy is no longer working. […] Immunotherapy uses your immune system to fight cancer. […] If cancer has spread to your bones, your doctor may recommend a bone-building drug to reduce your risk of broken bones or reduce bone pain you may experience. […] Radiation therapy and surgery may be used in certain situations to control signs and symptoms of advanced breast cancer.

• #25 How are Treatments Different for Recurrent Breast Cancer?

  https://www.cancercarebrevard.com/blog/how-are-treatments-different-for-recurrent-breast-cancer

  A distant recurrence of breast cancer is the most difficult type to treat. […] Treatment methods depend on the recurring cancers location. […] Treatment balances sufficient medication to control symptoms with minimizing the medications toxic effects. […] Hormone therapy is often the first treatment if your cancer is hormone receptor-positive. […] Chemotherapy is used if your cancer is hormone receptor-negative or if hormone therapy has stopped working. […] Thanks to extensive breast cancer research, including clinical trials available through Cancer Care Centers of Brevard (CCCB), there are new treatments being approved by the FDA to assist with metastatic and recurrent breast cancer.

• #26 Treatment Options for Newly Diagnosed or Recurrent Breast Cancer Subset

  https://www.curetoday.com/view/treatment-options-for-newly-diagnosed-or-recurrent-breast-cancer-subset

  An expert explained the different treatment options for patients with estrogen receptor-positive, HER2-negative breast cancer that has recently been diagnosed or has recurred. […] Vidal emphasized the need to determine the first-line treatment for patients with breast cancer, whether they are newly diagnosed or experiencing a recurrence. […] The treatment of ESR1 mutated receptors may include options like Soltamox, Faslodex, aromatase inhibitors and CDK4/6 inhibitors. The standard of care for first-line therapy involves a combination of CDK4/6 inhibitors and anti-estrogen therapy, as this approach tends to offer improved disease control and longer survival compared to anti-estrogen therapy alone. […] The overarching goal of hormonal therapy is to reduce the risk of breast cancer recurrence and keep the patient free from cancer for as long as possible. However, even with hormonal therapy, there is always a chance of cancer recurrence. Decisions to change therapy are based on factors such as patient tolerance, therapeutic benefits and the tumors response. A benefit is not just limited to tumor shrinkage; stable disease, where the tumor does not grow, is also considered a positive outcome. If there is evidence of tumor growth, it indicates the current therapy is ineffective, and a new approach must be explored.

• #27 Recurrent breast cancer – Hancock Health

  https://www.hancockhealth.org/mayo-health-library/recurrent-breast-cancer/

  Treatment for a local recurrence typically starts with an operation and may include radiation if you haven’t had it before. Chemotherapy and hormone therapy also may be recommended. […] Many treatments exist for metastatic breast cancer. Your options will depend on where your cancer has spread. If one treatment doesn’t work or stops working, you may be able to try other treatments. […] In general, the goal of treatment for metastatic breast cancer isn’t to cure the disease. Treatment may allow you to live longer and can help relieve symptoms the cancer is causing. Your doctor works to achieve a balance between controlling your symptoms while minimizing toxic effects from treatment. The aim is to help you live as well as possible for as long as possible.

• #28 Understanding Breast Cancer Recurrence

  https://www.oregoncancer.com/breast-cancer/recurrence

  Distant recurrence occurs when breast cancer spreads beyond the original site to areas such as the bones, lungs, or brain, making treatment more challenging. Surgery is rarely an option for treating distant recurrent breast cancer. However, several systemic therapies can be used, including: Hormone Therapy: This treatment blocks hormone receptors fueling cancer growth and can be used before or alongside chemotherapy. […] Palliative Care: Focuses on managing breast cancer symptoms and improving quality of life, which may include bone-building medications and radiation therapy.

• #29 Recurrent Breast Cancer

  https://www.texasoncology.com/types-of-cancer/breast-cancer/recurrent-breast-cancer

  Treatment options for these patients typically include a taxane alone or in combination with another chemotherapy drug. […] The growth of some breast cancer cells can be prevented or slowed by reducing the exposure to estrogen. […] Currently, many women with estrogen receptor-positive breast cancer are initially treated with tamoxifen, a hormonal therapy drug that acts by blocking estrogen receptors. […] Therapy for recurrent, hormone-resistant breast cancer may differ based on which treatment was previously administered. […] Bisphosphonates are a class of drugs that decrease the rate of bone destruction in patients with cancer. […] Clinical studies have shown that bisphosphonate therapy can prevent or delay bone destruction, including fractures and related pain, in women with breast cancer that has spread to the bone. […] The development of more effective cancer treatments requires that new and innovative therapies are evaluated with cancer patients. […] Future progress in the treatment of recurrent breast cancer will result from the continued evaluation of new treatments in clinical trials.

• #30 Recurrent Breast Cancer

  https://www.texasoncology.com/types-of-cancer/breast-cancer/recurrent-breast-cancer

  Targeted therapies are treatments that can selectively target cancer cells and minimize damage to normal, healthy cells. […] The development of treatments that specifically target HER2-positive cells has improved outcomes among women with HER2-positive breast cancer. […] Research indicates that the addition of Avastin to chemotherapy in the treatment of patients with advanced breast cancer produces more anti-cancer responses and longer cancer-free survival than chemotherapy alone. […] The first chemotherapy treatment is called first-line and additional chemotherapy for cancer that has recurred is referred to as second-line. […] The type of second-line therapy that is selected and its effectiveness depends on which first-line chemotherapy the patient received. […] Patients who have stopped responding to anthracyclines, a class of drugs that includes doxorubicin, are said to be anthracycline-resistant.

• #31 Adding ribociclib to hormone therapy reduces the risk of breast cancer recurrence | UCLA Health

  https://www.uclahealth.org/news/release/adding-ribociclib-hormone-therapy-reduces-risk-breast-cancer

  A new treatment approach that combines a targeted therapy drug with hormone therapy significantly increased the amount of time a person with stage 2 or 3 HR-positive, HER2-negative early breast cancer lives without the cancer returning, according to a new study co-led by UCLA Health Jonsson Comprehensive Cancer Center investigators. […] The team found adding ribociclib, a drug that belongs to a class of CDK4/6 inhibitors, to standard hormone therapy not only improved invasive-free survival in women with this type of early-stage breast cancer, but also improves distant disease-free survival and recurrence-free survival. […] We found that adding ribociclib to the standard hormone therapy resulted in a relative reduction in the recurrence rate by as much as 25%, said first author of the study Dr. Dennis Slamon, chair of hematology-oncology at the David Geffen School of Medicine at UCLA and director of clinical and translational research at the UCLA Health Jonsson Comprehensive Cancer Center.

• #32 Treatment Approaches for Recurrent Triple-Negative Breast Cancer

  https://www.cancernetwork.com/view/treatment-approaches-for-recurrent-triple-negative-breast-cancer

  A lot of people use gemcitabine and carboplatin, but I have to say that in a patient like this, I tend to give first-line chemotherapy with either a taxane, where I think we have some inferential data suggesting it might be a little bit better, and I give nab-paclitaxel [Abraxane]. […] I would think of infusive chemotherapy for something like taxanes or carboplatin. […] Weve seen in the TNT trial that they both can achieve around a 30% response rate. […] But were looking at trials that try to combine immunotherapy, even in this subset of patients, to see if we can somehow turn cold tumors into hot tumors. […] We are running the Saci-IO trials that is combining sacituzumab [govitecan (Trodelvy)] with or without the addition of pembrolizumab in this setting. […] But for the time being, chemotherapy remains the mainstay here. […] In this case, probably the fact that the patient received it in the post-neoadjuvant setting makes it less appealing. […] But still, we hope that we can get some response despite being only chemotherapy.

• #33 Azthena logo with the word Azthena

  https://www.news-medical.net/news/20240320/New-treatment-approach-improves-recurrence-free-survival-in-early-breast-cancer-patients.aspx

  A new treatment approach that combines a targeted therapy drug with hormone therapy significantly increased the amount of time a person with stage 2 or 3 HR-positive, HER2-negative early breast cancer lives without the cancer returning, according to a new study co-led by UCLA Health Jonsson Comprehensive Cancer Center investigators. […] The team found adding ribociclib, a drug that belongs to a class of CDK4/6 inhibitors, to standard hormone therapy not only improved invasive-free survival in women with this type of early-stage breast cancer, but also improves distant disease-free survival and recurrence-free survival. […] We found that adding ribociclib to the standard hormone therapy resulted in a relative reduction in the recurrence rate by as much as 25%. […] The study’s secondary endpoint, distant disease-free survival and recurrence-free survival, also favored treatment with ribociclib and endocrine therapy. The distant-free survival rates were 90.8% for the combination arm, compared to 88.6% for endocrine therapy alone. Patients on the combination had a 91.7% recurrence-free survival compared to 88.6% for endocrine therapy alone. […] „Overall, the NATALEE trial supports ribociclib plus endocrine therapy as a new treatment option for a much larger population of patients with HR-positive, HER2-negative early breast cancer,” said Slamon. „These findings should change how we evaluate and treat patients.”

• #34 Immunotherapy for Breast Cancer – Cancer Research Institute

  https://www.cancerresearch.org/cancer-types/breast-cancer

  Immunotherapy for breast cancer is developing rapidly as new studies demonstrate improved outcomes in subsets of breast cancer. […] Current methods for breast cancer treatment typically involve surgery if the disease is diagnosed early. Depending on the stage and molecular characteristics of the cancer when diagnosed, breast cancer treatment may involve chemotherapy, hormonal therapy, surgery and/or radiation. […] Although breast cancer was once regarded as difficult to treat with immunotherapy because it is immunologically “cold,” clinical studies and new drugs have shown that immunotherapy treatment has the potential to improve outcomes for breast cancer patients. […] Traditional treatments for breast cancer include chemotherapy, radiation, and surgery. Hormonal therapy, which can reduce levels of estrogen and progesterone, may also be used to prevent disease recurrence in women with hormone receptor-positive tumors.

• #35 Treatment Approaches for Recurrent Triple-Negative Breast Cancer

  https://www.cancernetwork.com/view/treatment-approaches-for-recurrent-triple-negative-breast-cancer

  This patient has a longer time to recurrent disease. She finished all her treatment in September 2020 and she didnt have recurrent disease again until June 2022, when she comes in with symptoms that are really consistent with having liver metastases, fatigue, and right upper quadrant discomfort. […] But the first thing that we do when were looking at a patient like this, other than feel really sorry that they have recurrent disease, is to first look to see whether or not theyre eligible for pembrolizumab [Keytruda] from the KEYNOTE-355 trial, which showed improved survival with the addition of pembrolizumab in that setting. […] Shes quite far out, more than a year, which usually is our differentiation in terms of trying to decide what to do and our standard in the first-line setting is chemotherapy.

• #36 Understanding Breast Cancer Recurrence

  https://www.oregoncancer.com/breast-cancer/recurrence

  When breast cancer returns after successful treatment, it is called recurrent breast cancer. It occurs when lingering cancer cells start to grow again, following a remission period. Thankfully many new treatments are available through Willamette Valley Cancer Institute, including access to clinical trials with the most advanced treatment options available to our patients. […] Even if recurrent breast cancer cannot be put into remission, it can often be managed using long-term therapies such as hormone or targeted therapies. […] When breast cancer has recurred, our oncologists will work with our team to develop a personalized treatment plan based on the location and size of the recurrence. Biomarker test results will also indicate whether a targeted therapy will be effective. Clinical trials may also be available to patients whose breast cancer recurs.

• #37 Multidisciplinary Management of Locoregional Recurrent Breast Cancer

  https://pmc.ncbi.nlm.nih.gov/articles/PMC8462537/

  Combined modality treatment, if feasible, achieves the best outcome. […] For patients who develop recurrence in a previously radiated chest wall, the treatment options are more difficult. […] Patients presenting with isolated nodal recurrence are generally considered for surgical extirpation if the disease is resectable. […] Data regarding optimal systemic therapy recommendations and sequencing of systemic treatments and local therapies in the setting of an isolated LRR are limited. […] Treatment plans for patients who present with LRR after treatment of primary breast cancer can represent some of the most challenging decisions confronting oncology teams, in part because of the diversity of previous treatments and heterogeneity of prognostic factors. Some patients have potentially curable disease, and as such, should receive integrated plans that coordinate surgical, radiologic, and systemic treatments.

• #38 Multidisciplinary Approaches to Chest Wall Recurrences of Breast Cancer

  https://www.cancernetwork.com/view/multidisciplinary-approaches-chest-wall-recurrences-breast-cancer

  Systemic therapy, therefore, is part of the standard of care for many patients with local recurrences. […] A well-coordinated multidisciplinary approach in well-selected patients with an isolated chest wall recurrence of breast cancer is not only feasible but also desirable for long-term local control and improved survival.

• #39 Recurrent breast cancer – Symptoms and causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/recurrent-breast-cancer/symptoms-causes/syc-20377135

  Strategies that have been linked to a reduced risk of breast cancer recurrence include: Hormone therapy. Taking hormone therapy after your initial treatment may reduce the risk of recurrence if you have hormone receptor positive breast cancer. Hormone therapy may continue for at least five years. […] Chemotherapy. For people with breast cancer who have an increased risk of cancer recurrence, chemotherapy has been shown to decrease the chance that cancer will recur, and those who receive chemotherapy live longer. […] Radiation therapy. People who’ve had a breast-sparing operation to treat their breast cancer and those who had a large tumor or inflammatory breast cancer have a lower chance of the cancer recurring if they’re treated with radiation therapy. […] Targeted therapy. If your cancer makes extra HER2 protein, drugs that target that protein can help decrease the chance of the cancer recurring.

• #40 Recurrent breast cancer – Symptoms and causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/recurrent-breast-cancer/symptoms-causes/syc-20377135

  Bone-building drugs. Taking bone-building drugs reduces the risk of cancer recurring in the bones (bone metastasis) in people with an increased risk for breast cancer recurrence. […] Maintaining a healthy weight. Maintaining a healthy weight may help decrease the risk of recurrent breast cancer. […] Exercising. Regular exercise may reduce your risk of breast cancer recurrence. […] Choosing a healthy diet. Focus on including lots of vegetables, fruits and whole grains in your diet. If you choose to drink alcohol, limit yourself to one drink a day.

• #41 What Helps to Prevent Breast Cancer Recurrence

  https://www.webmd.com/breast-cancer/breast-cancer-recurrence-prevention

  If you’ve had breast cancer and you’ve been through the hurdles of treatment, your biggest fear might be that it may come back. […] In most cases, it doesn’t come back, but that can’t be ruled out. […] If there’s a recurrence, breast cancer is most likely to come back within the first two years after you’ve finished treatment. […] Research shows that lifestyle changes and medications can help you stay as healthy as possible and may help reduce your risk of having cancer again. […] A recent study shows that if you regularly exercise even for at least 2.5 hours per week, you can improve your overall health. It may also lower the risk of your cancer coming back. […] Studies show that there is a link between moderate and heavy alcohol use and breast cancer. Alcohol is known to raise estrogen levels in your blood. This makes it more likely for you to get cancer again.

• #42 What Helps to Prevent Breast Cancer Recurrence

  https://www.webmd.com/breast-cancer/breast-cancer-recurrence-prevention

  If you’ve not already quit, this is a top priority for your overall health and will make it less likely for your breast cancer to return. […] After you complete your cancer treatment, if you have a high chance of your cancer returning, your doctor may prescribe certain drugs to reduce your risk. […] Tamoxifen is one such drug. Doctors often prescribe this drug to lower the chances of cancer coming back in women who have been treated for early-stage, hormone receptor-positive breast cancer. […] While rare, tamoxifen can also cause blood clots in your leg veins or lungs. This can be a serious side effect that may need medical attention right away. […] If you have a high risk of breast cancer coming back, aromatase inhibitor (AI) drugs may be another option. […] It’s important to take the time to heal and prioritize your overall emotional and mental health, along with your physical health. […] Keep in mind that if breast cancer does come back, it is not your fault and it can often be treated.

• #43 Multidisciplinary Management of Locoregional Recurrent Breast Cancer

  https://pmc.ncbi.nlm.nih.gov/articles/PMC8462537/

  The prognosis of patients who develop LRR after an initial mastectomy is unfortunately poor. Even in the setting of isolated LRR disease, numerous published datasets suggest that patients have a high risk of developing subsequent metastatic disease. […] Several publications have provided insights into the prognostic factors associated with outcome for patients with LRR after mastectomy. […] Although these data are useful for individualizing a patients prognosis, it is also important to recognize the limitations of these datasets. […] If the patient is a candidate for surgery, chemotherapy, and radiation, our preference is to mark the sites of resectable disease and proceed initially with systemic therapy. This gives the clinicians an opportunity to assess response and to switch therapies if minimal response or progression of disease occurs.

• #44 Breast Cancer Recurrence: Causes, Symptoms, and Treatment | Breast Care Center Miami

  https://www.toplinemd.com/breast-care-center-of-miami/blog/breast-cancer-recurrence-causes-symptoms-and-treatment/

  Metastatic breast cancer is treatable in a variety of ways. Depending on how far spread the cancer is, treatment options may change. It’s possible to try alternative treatments if the initial one doesn’t pan out or stops working. […] As a rule, curing metastatic breast cancer isn’t the goal of treatment. Cancer treatment has the potential to lengthen one’s life and lessen the severity of the patient’s symptoms. The doctor strikes a delicate balance between alleviating the symptoms and protecting the patient from any potentially harmful side effects. The goal is to ensure that patients have the highest possible quality of life for the longest time.

• #45 Multidisciplinary Approaches to Chest Wall Recurrences of Breast Cancer

  https://www.cancernetwork.com/view/multidisciplinary-approaches-chest-wall-recurrences-breast-cancer

  A multidisciplinary approach to these patients, including surgical resection with reconstruction, systemic therapy, and radiation therapy, can often lead to long-term survival. […] Surgical resection is recommended in cases of local recurrence, if possible. […] Once considered heroic or radical, the full-thickness resection of the chest wall for complete extirpation of a breast cancer recurrence has been notably successful in extending survival in well-selected patients. […] In patients undergoing surgical resection with curative intent, 5-year survival was 41.3%. […] The addition of concurrent chemotherapy for these patients may or may not improve local control depending on the study, agent used, and tumor subtype. […] Radiation therapy is an important part of multidisciplinary treatment for operable and inoperable chest wall recurrences of breast cancer and appears to benefit even patients who have been previously irradiated, without significant toxicity.

• #46 Immunotherapy for Breast Cancer – Cancer Research Institute

  https://www.cancerresearch.org/cancer-types/breast-cancer

  Immunotherapy is class of treatments that take advantage of a person’s own immune system to help kill cancer cells. There are several immunotherapy options for patients depending on their tumor type. […] New therapeutic strategies for breast cancer are needed to improve clinical outcomes for breast cancer patients, particularly those with advanced disease. Other immunotherapies are currently being tested in breast cancer clinical trials and several have shown impressive results. […] Because current treatments are unlikely to cure advanced breast cancer, patients in otherwise good health are encouraged to think about taking part in clinical trials.

• #47 Stage 4 Breast Cancer Recurrence and Remission

  https://www.healthline.com/health/stage-4-breast-cancer-recurrence-and-remission

  Although theres no cure for stage 4 breast cancer, treatments are available, and survival rates continue to improve. […] The 5-year relative survival rate for people who have been diagnosed with stage 4 breast cancer is 31%. This means that, on average, people who have stage 4 breast cancer are about 31% as likely as people who dont have that cancer to live for at least 5 years after receiving a diagnosis. […] Living with stage 4 breast cancer is challenging. But cancer treatments are improving every year and can help people manage the cancer better. […] People with stage 4 cancer can experience remission when the cancer is no longer detectable. They can also have a recurrence of the cancer, which means it returns.

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