Materiały źródłowe

• #1 Sclerosing mesenteritis: a comprehensive clinical review

  https://atm.amegroups.org/article/view/20473/html

  Sclerosing mesenteritis is a rare disease entity initially described in 1924 with a prevalence reported to be less than 1%. […] Treatment for this little-understood disease ranges from surgical intervention for patients presenting with obstructive symptoms to immunosuppressive medical therapy for patients presenting with pain. […] A significant variety of medical interventions have been used and reported in the literature to treat this challenging diagnosis. Medical treatments have mainly focused on the use of steroids, and less frequently colchicine, tamoxifen, 6-mercaptopurine, antibiotics, azathioprine, methotrexate, infliximab have also been used. […] In one of the largest studies published to date by Akram et al., they proposed a medical treatment algorithm of using tamoxifen twice daily and a prednisone taper completed over three months. […] It seems reasonable to treat patients with their approach of tamoxifen and prednisone if they are not a surgical candidate and continue to have symptoms not explained by another etiology.

• #2 Treatment options for spontaneous and postoperative sclerosing mesenteritis

  https://www.wjgnet.com/1948-9366/full/v8/i11/761.htm

  Sclerosing mesenteritis is a rare pathology with only a few described cases in the literature. […] So far there are no distinct treatment algorithms, so the patients were treated differently, including steroids, antibiotics and watchful waiting. […] In addition, we reviewed the current literature on treatment options for this rare disease. […] The only evidence in the treatment of these patients is that, in the case of non-resolving bowel obstruction, surgery is needed. […] Several therapeutic approaches with agents such as steroids, colchicine and azathioprine have been described with various therapeutic effects. […] However, the symptomatic sclerosing mesenteritis must be treated surgically or with a trial of immunosuppressive medication. […] The only evidence is that in the case of non-resolving bowel obstruction or an advanced inflammatory reaction, surgical resection is needed.

• #3 Sclerosing mesenteritis – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/sclerosing-mesenteritis/diagnosis-treatment/drc-20450343

  You may be diagnosed with sclerosing mesenteritis while you are receiving care for another condition. If you are not experiencing discomfort from sclerosing mesenteritis, you may not need treatment. Instead, occasional imaging tests may be recommended to monitor your condition. […] If you begin to experience symptoms of sclerosing mesenteritis, you may choose to begin treatment. […] Medicines for sclerosing mesenteritis are used to control inflammation. Medicines may include: […] Corticosteroids such as prednisone control inflammation. Corticosteroids can be used alone but are usually combined with other medicines. They are not generally used for more than 3 to 4 months because of side effects. […] Hormone treatments such as tamoxifen (Soltamox) may slow the growth of scar tissue. Tamoxifen is typically combined with corticosteroids or other medicines and may be used long term. Tamoxifen increases the risk of blood clots and is typically combined with a daily aspirin to reduce this risk. Progesterone (Prometrium) may be used as an alternative to tamoxifen, but it also has significant side effects. […] Several other medicines have been used to treat sclerosing mesenteritis, such as azathioprine (Imuran, Azasan), colchicine (Colcrys, Mitigare), cyclophosphamide and thalidomide (Thalomid). […] You may need surgery if the scar tissue blocks food from moving through your digestive tract.

• #4 Sclerosing Mesenteritis: Definition, Types & Treatment

  https://my.clevelandclinic.org/health/diseases/15284-sclerosing-mesenteritis

  Many people will never need treatment. Sclerosing mesenteritis tends to be self-limiting and often goes away by itself. It may never cause you symptoms or may cause only mild discomfort that you can manage with over-the-counter (OTC) medications. However, if you do have persistent symptoms, your healthcare provider will offer various prescription medications to treat them. These may include: […] Corticosteroids to control inflammation, such as prednisone. […] Immunosuppressants to reduce the autoimmune response, such as azathioprine. […] Hormonal therapy, such as tamoxifen.

• #5 Mesenteric Panniculitis: Symptoms, Causes, and Treatment

  https://www.webmd.com/digestive-disorders/what-is-mesenteric-panniculitis

  Doctors also refer to this condition as sclerosing mesenteritis, depending on the stage of inflammation. […] Initially, you may not need any treatment for the condition. Doctors use a „watch and wait” approach, in which they only monitor you rather than giving any kind of medications or other treatment options. Your doctor will check the CT scan results to see if inflammation is increasing or getting worse. In most cases, the condition goes away on its own. […] If extreme inflammation is causing you pain and discomfort, your doctor will prescribe medications that reduce inflammation by suppressing the response of the immune system. A commonly prescribed class of drugs is corticosteroids. […] In general, surgery is not the preferred treatment unless the inflammation is blocking the small intestine.

• #6 Mesenteric Panniculitis: Diet, Treatment, Symptoms & What It Is

  https://my.clevelandclinic.org/health/diseases/23910-mesenteric-panniculitis

  Not everyone needs treatment for mesenteric panniculitis. If you have no symptoms or mild symptoms, your healthcare provider may simply wait and watch it to see if your condition changes. Mesenteric panniculitis usually doesn’t get worse over time, and it often goes away on its own. If you do have symptoms, there are a few standard types of medications that healthcare providers use to treat them. […] Corticosteroids, drugs that reduce inflammation, are the first line of treatment for mesentery panniculitis, and they often do the trick. In some cases, your healthcare provider may prescribe additional medications to treat side effects of the condition like nausea. These medications work gradually, so it may be weeks until your symptoms are gone. […] If corticosteroids don’t work for you, your healthcare provider may prescribe immunosuppressants. These drugs suppress your overactive immune response. Or they may try low-dose naltrexone (LDN), which also works to modulate your immune system, but by a different approach. Healthcare providers use a trial-and-error process to find the best medication for your symptoms.

• #7 Sclerosing mesenteritis – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/sclerosing-mesenteritis/diagnosis-treatment/drc-20450343

  You may be diagnosed with sclerosing mesenteritis while you are receiving care for another condition. If you are not experiencing discomfort from sclerosing mesenteritis, you may not need treatment. Instead, occasional imaging tests may be recommended to monitor your condition. […] If you begin to experience symptoms of sclerosing mesenteritis, you may choose to begin treatment. […] Medicines for sclerosing mesenteritis are used to control inflammation. Medicines may include: […] Corticosteroids such as prednisone control inflammation. Corticosteroids can be used alone but are usually combined with other medicines. They are not generally used for more than 3 to 4 months because of side effects. […] Hormone treatments such as tamoxifen (Soltamox) may slow the growth of scar tissue. Tamoxifen is typically combined with corticosteroids or other medicines and may be used long term. Tamoxifen increases the risk of blood clots and is typically combined with a daily aspirin to reduce this risk. Progesterone (Prometrium) may be used as an alternative to tamoxifen, but it also has significant side effects. […] Several other medicines have been used to treat sclerosing mesenteritis, such as azathioprine (Imuran, Azasan), colchicine (Colcrys, Mitigare), cyclophosphamide and thalidomide (Thalomid). […] You may need surgery if the scar tissue blocks food from moving through your digestive tract.

• #8 Sclerosing mesenteritis // Middlesex Health

  https://middlesexhealth.org/learning-center/diseases-and-conditions/sclerosing-mesenteritis

  You may be diagnosed with sclerosing mesenteritis while you are receiving care for another condition. If you are not experiencing discomfort from sclerosing mesenteritis, you may not need treatment. Instead, occasional imaging tests may be recommended to monitor your condition. […] If you begin to experience symptoms of sclerosing mesenteritis, you may choose to begin treatment. […] Medicines for sclerosing mesenteritis are used to control inflammation. Medicines may include: […] Corticosteroids such as prednisone control inflammation. Corticosteroids can be used alone but are usually combined with other medicines. […] Hormone treatments such as tamoxifen (Soltamox) may slow the growth of scar tissue. […] Several other medicines have been used to treat sclerosing mesenteritis, such as azathioprine (Imuran, Azasan), colchicine (Colcrys, Mitigare), cyclophosphamide and thalidomide (Thalomid). […] You may need surgery if the scar tissue blocks food from moving through your digestive tract.

• #9 Mesenteric Panniculitis: Diet, Treatment, Symptoms & What It Is

  https://my.clevelandclinic.org/health/diseases/23910-mesenteric-panniculitis

  Not everyone needs treatment for mesenteric panniculitis. If you have no symptoms or mild symptoms, your healthcare provider may simply wait and watch it to see if your condition changes. Mesenteric panniculitis usually doesn’t get worse over time, and it often goes away on its own. If you do have symptoms, there are a few standard types of medications that healthcare providers use to treat them. […] Corticosteroids, drugs that reduce inflammation, are the first line of treatment for mesentery panniculitis, and they often do the trick. In some cases, your healthcare provider may prescribe additional medications to treat side effects of the condition like nausea. These medications work gradually, so it may be weeks until your symptoms are gone. […] If corticosteroids don’t work for you, your healthcare provider may prescribe immunosuppressants. These drugs suppress your overactive immune response. Or they may try low-dose naltrexone (LDN), which also works to modulate your immune system, but by a different approach. Healthcare providers use a trial-and-error process to find the best medication for your symptoms.

• #10 Sclerosing mesenteritis and mesenteric panniculitis – clinical experience and radiological features | BMC Gastroenterology | Full Text

  https://bmcgastroenterol.biomedcentral.com/articles/10.1186/s12876-017-0632-7

  Sclerosing mesenteritis (SM) is a rare but probably underdiagnosed condition of inflammation in the mesentery. […] The first line treatment of SM is corticosteroids but sometimes other immune modulating agents such as Thiopurines and TNF inhibitors have been tried as well as colchicine and thalidomide. […] Corticosteroids were initiated in three out of four patients. In these three cases, the treatment was effective on abdominal pain, biomarkers and radiological changes, usually within days. […] We recommend prednisolone 40 mg and effect evaluation within 2 weeks. If effective, tapering off with 5 mg per week is appropriate, slower below 10 mg. […] In our study, no conclusions can be drawn considering immunomodulation treatment in the SM group. Further studies are needed although the impression from our cases is that Azathioprine and anti TNF can be of value. […] We propose that the term SM should be reserved for this condition.

• #11 Mayo Clinic Health Library – Sclerosing mesenteritis | Swiss Medical Network

  https://www.swissmedical.net/en/healtcare-library/con-20213811

  Sclerosing mesenteritis is a rare condition that may lead to blockage in the small intestine. Learn about treatment at Mayo Clinic. […] You may be diagnosed with sclerosing mesenteritis while you are receiving care for another condition. If you are not experiencing discomfort from sclerosing mesenteritis, you may not need treatment. Instead, occasional imaging tests may be recommended to monitor your condition. […] If you begin to experience symptoms of sclerosing mesenteritis, you may choose to begin treatment. […] Medicines for sclerosing mesenteritis are used to control inflammation. Medicines may include: […] Corticosteroids such as prednisone control inflammation. Corticosteroids can be used alone but are usually combined with other medicines. They are not generally used for more than 3 to 4 months because of side effects.

• #12 Sclerosing mesenteritis – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/sclerosing-mesenteritis/diagnosis-treatment/drc-20450343

  You may be diagnosed with sclerosing mesenteritis while you are receiving care for another condition. If you are not experiencing discomfort from sclerosing mesenteritis, you may not need treatment. Instead, occasional imaging tests may be recommended to monitor your condition. […] If you begin to experience symptoms of sclerosing mesenteritis, you may choose to begin treatment. […] Medicines for sclerosing mesenteritis are used to control inflammation. Medicines may include: […] Corticosteroids such as prednisone control inflammation. Corticosteroids can be used alone but are usually combined with other medicines. They are not generally used for more than 3 to 4 months because of side effects. […] Hormone treatments such as tamoxifen (Soltamox) may slow the growth of scar tissue. Tamoxifen is typically combined with corticosteroids or other medicines and may be used long term. Tamoxifen increases the risk of blood clots and is typically combined with a daily aspirin to reduce this risk. Progesterone (Prometrium) may be used as an alternative to tamoxifen, but it also has significant side effects. […] Several other medicines have been used to treat sclerosing mesenteritis, such as azathioprine (Imuran, Azasan), colchicine (Colcrys, Mitigare), cyclophosphamide and thalidomide (Thalomid). […] You may need surgery if the scar tissue blocks food from moving through your digestive tract.

• #13 Sclerosing mesenteritis – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/sclerosing-mesenteritis/diagnosis-treatment/drc-20450343

  You may be diagnosed with sclerosing mesenteritis while you are receiving care for another condition. If you are not experiencing discomfort from sclerosing mesenteritis, you may not need treatment. Instead, occasional imaging tests may be recommended to monitor your condition. […] If you begin to experience symptoms of sclerosing mesenteritis, you may choose to begin treatment. […] Medicines for sclerosing mesenteritis are used to control inflammation. Medicines may include: […] Corticosteroids such as prednisone control inflammation. Corticosteroids can be used alone but are usually combined with other medicines. They are not generally used for more than 3 to 4 months because of side effects. […] Hormone treatments such as tamoxifen (Soltamox) may slow the growth of scar tissue. Tamoxifen is typically combined with corticosteroids or other medicines and may be used long term. Tamoxifen increases the risk of blood clots and is typically combined with a daily aspirin to reduce this risk. Progesterone (Prometrium) may be used as an alternative to tamoxifen, but it also has significant side effects. […] Several other medicines have been used to treat sclerosing mesenteritis, such as azathioprine (Imuran, Azasan), colchicine (Colcrys, Mitigare), cyclophosphamide and thalidomide (Thalomid). […] You may need surgery if the scar tissue blocks food from moving through your digestive tract.

• #14 Mayo Clinic Health Library – Sclerosing mesenteritis | Swiss Medical Network

  https://www.swissmedical.net/en/healtcare-library/con-20213811

  Hormone treatments such as tamoxifen (Soltamox) may slow the growth of scar tissue. Tamoxifen is typically combined with corticosteroids or other medicines and may be used long term. Tamoxifen increases the risk of blood clots and is typically combined with a daily aspirin to reduce this risk. […] You may need surgery if the scar tissue blocks food from moving through your digestive tract.

• #15 Sclerosing mesenteritis: a comprehensive clinical review

  https://atm.amegroups.org/article/view/20473/html

  Sclerosing mesenteritis is a rare disease entity initially described in 1924 with a prevalence reported to be less than 1%. […] Treatment for this little-understood disease ranges from surgical intervention for patients presenting with obstructive symptoms to immunosuppressive medical therapy for patients presenting with pain. […] A significant variety of medical interventions have been used and reported in the literature to treat this challenging diagnosis. Medical treatments have mainly focused on the use of steroids, and less frequently colchicine, tamoxifen, 6-mercaptopurine, antibiotics, azathioprine, methotrexate, infliximab have also been used. […] In one of the largest studies published to date by Akram et al., they proposed a medical treatment algorithm of using tamoxifen twice daily and a prednisone taper completed over three months. […] It seems reasonable to treat patients with their approach of tamoxifen and prednisone if they are not a surgical candidate and continue to have symptoms not explained by another etiology.

• #16 Sclerosing mesenteritis: clinical features, treatment, and outcome in ninety-two patients – PubMed

  https://pubmed.ncbi.nlm.nih.gov/17478346/

  Sclerosing mesenteritis is a rare non-neoplastic disease that affects the small bowel mesentery with chronic fibrosing inflammation. There are few data on the natural history and therapeutic options for this condition. […] Treatment included medical therapy alone in 26%, surgery alone in 13%, surgery followed by medical therapy in 9%, and 52% received no treatment. Ten percent responded to surgery alone, 20% responded to additional medical treatment after surgery, and 38% responded to medical therapy alone. Tamoxifen in combination with prednisone was used in 20 patients, and 60% improved. Non-tamoxifen-based regimens were used in 12 patients, and 8% improved. […] Our results suggest that symptomatic patients might benefit from medical therapy, particularly tamoxifen and prednisone combination treatment. Long-term follow-up is needed to substantiate these results.

• #17 A Clinical Review of Mesenteric Panniculitis – Gastroenterology & Hepatology

  https://www.gastroenterologyandhepatology.net/archives/april-2023/a-clinical-review-of-mesenteric-panniculitis/

  Considering the benign nature of MP, therapeutic decisions should be guided by the severity of symptoms and presence of complications. Asymptomatic patients who present with MP as an incidental finding do not need to be started on treatment. […] In this case series, which is the largest one published to date, medical treatment of tamoxifen twice daily and a prednisone taper over 3 months was administered in 20 patients. Of these, 12 (60%) responded to therapy within 12 to 16 weeks, with 6 patients (30%) having persistent symptoms and 2 patients (10%) showing disease progression. […] A recently published retrospective study by Cortés and colleagues that determined the long-term management outcomes of 103 patients with biopsy-proven MP concluded that prednisone plus colchicine has a similar efficacy to prednisone plus tamoxifen for the initial treatment and 14-month follow-up of MP.

• #18 Sclerosing mesenteritis – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/sclerosing-mesenteritis/diagnosis-treatment/drc-20450343

  You may be diagnosed with sclerosing mesenteritis while you are receiving care for another condition. If you are not experiencing discomfort from sclerosing mesenteritis, you may not need treatment. Instead, occasional imaging tests may be recommended to monitor your condition. […] If you begin to experience symptoms of sclerosing mesenteritis, you may choose to begin treatment. […] Medicines for sclerosing mesenteritis are used to control inflammation. Medicines may include: […] Corticosteroids such as prednisone control inflammation. Corticosteroids can be used alone but are usually combined with other medicines. They are not generally used for more than 3 to 4 months because of side effects. […] Hormone treatments such as tamoxifen (Soltamox) may slow the growth of scar tissue. Tamoxifen is typically combined with corticosteroids or other medicines and may be used long term. Tamoxifen increases the risk of blood clots and is typically combined with a daily aspirin to reduce this risk. Progesterone (Prometrium) may be used as an alternative to tamoxifen, but it also has significant side effects. […] Several other medicines have been used to treat sclerosing mesenteritis, such as azathioprine (Imuran, Azasan), colchicine (Colcrys, Mitigare), cyclophosphamide and thalidomide (Thalomid). […] You may need surgery if the scar tissue blocks food from moving through your digestive tract.

• #19 Research forges path to effective treatment for sclerosing mesenteritis – Mayo Clinic News Network

  https://newsnetwork.mayoclinic.org/discussion/research-forges-path-to-effective-treatment-for-sclerosing-mesenteritis/

  With more than three decades of experience as a nurse and nurse manager, Carol Bolton of Exeter, Calif., was acquainted with most medical conditions. […] Most importantly, the research yielded a treatment protocol that has shown to be effective in treating SM. […] „My treatment began with an initial burst of prednisone for several months, which I was tapered off of,” says Carol. „Also, I have been on raloxifene (a drug used for post-cancer care and osteoporosis) since my diagnosis in 2005.” […] The most widely prescribed medical therapy for sclerosing mesenteritis is tamoxifen (known to help prevent the recurrence of breast cancer), typically used in combination with prednisone, which has the effect of easing pain by settling inflammation or causing scars to regress. […] Surgery to remove obstructions or growths is another option.

• #20 Sclerosing mesenteritis – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/sclerosing-mesenteritis/diagnosis-treatment/drc-20450343

  You may be diagnosed with sclerosing mesenteritis while you are receiving care for another condition. If you are not experiencing discomfort from sclerosing mesenteritis, you may not need treatment. Instead, occasional imaging tests may be recommended to monitor your condition. […] If you begin to experience symptoms of sclerosing mesenteritis, you may choose to begin treatment. […] Medicines for sclerosing mesenteritis are used to control inflammation. Medicines may include: […] Corticosteroids such as prednisone control inflammation. Corticosteroids can be used alone but are usually combined with other medicines. They are not generally used for more than 3 to 4 months because of side effects. […] Hormone treatments such as tamoxifen (Soltamox) may slow the growth of scar tissue. Tamoxifen is typically combined with corticosteroids or other medicines and may be used long term. Tamoxifen increases the risk of blood clots and is typically combined with a daily aspirin to reduce this risk. Progesterone (Prometrium) may be used as an alternative to tamoxifen, but it also has significant side effects. […] Several other medicines have been used to treat sclerosing mesenteritis, such as azathioprine (Imuran, Azasan), colchicine (Colcrys, Mitigare), cyclophosphamide and thalidomide (Thalomid). […] You may need surgery if the scar tissue blocks food from moving through your digestive tract.

• #21 Sclerosing Mesenteritis : Causes, Symptoms and Treatment

  https://www.apollohospitals.com/diseases-and-conditions/what-are-the-causes-symptoms-and-treatment-for-sclerosing-mesenteritis

  Several other medicines have been used to treat sclerosing mesenteritis, such as azathioprine, colchicine, cyclophosphamide and thalidomide. […] In general, surgery for Sclerosing mesenteritis is the last resort to treat severe cases of. […] Minimally invasive surgical procedures are highly effective in treating rapidly progressive Sclerosing mesenteritis. […] The available treatment options are effective in relieving the symptoms.

• #22 Sclerosing mesenteritis: a comprehensive clinical review

  https://atm.amegroups.org/article/view/20473/html

  Sclerosing mesenteritis is a rare disease entity initially described in 1924 with a prevalence reported to be less than 1%. […] Treatment for this little-understood disease ranges from surgical intervention for patients presenting with obstructive symptoms to immunosuppressive medical therapy for patients presenting with pain. […] A significant variety of medical interventions have been used and reported in the literature to treat this challenging diagnosis. Medical treatments have mainly focused on the use of steroids, and less frequently colchicine, tamoxifen, 6-mercaptopurine, antibiotics, azathioprine, methotrexate, infliximab have also been used. […] In one of the largest studies published to date by Akram et al., they proposed a medical treatment algorithm of using tamoxifen twice daily and a prednisone taper completed over three months. […] It seems reasonable to treat patients with their approach of tamoxifen and prednisone if they are not a surgical candidate and continue to have symptoms not explained by another etiology.

• #23 Sclerosing Mesenteritis: Definition, Types & Treatment

  https://my.clevelandclinic.org/health/diseases/15284-sclerosing-mesenteritis

  Many people will never need treatment. Sclerosing mesenteritis tends to be self-limiting and often goes away by itself. It may never cause you symptoms or may cause only mild discomfort that you can manage with over-the-counter (OTC) medications. However, if you do have persistent symptoms, your healthcare provider will offer various prescription medications to treat them. These may include: […] Corticosteroids to control inflammation, such as prednisone. […] Immunosuppressants to reduce the autoimmune response, such as azathioprine. […] Hormonal therapy, such as tamoxifen.

• #24 Treatment options for spontaneous and postoperative sclerosing mesenteritis

  https://www.wjgnet.com/1948-9366/full/v8/i11/761.htm

  Sclerosing mesenteritis is a rare pathology with only a few described cases in the literature. […] So far there are no distinct treatment algorithms, so the patients were treated differently, including steroids, antibiotics and watchful waiting. […] In addition, we reviewed the current literature on treatment options for this rare disease. […] The only evidence in the treatment of these patients is that, in the case of non-resolving bowel obstruction, surgery is needed. […] Several therapeutic approaches with agents such as steroids, colchicine and azathioprine have been described with various therapeutic effects. […] However, the symptomatic sclerosing mesenteritis must be treated surgically or with a trial of immunosuppressive medication. […] The only evidence is that in the case of non-resolving bowel obstruction or an advanced inflammatory reaction, surgical resection is needed.

• #25

  https://link.springer.com/article/10.1007/s10620-021-07081-4

  Sclerosing mesenteritis is a rare condition characterized by chronic inflammation and fibrotic changes of the mesentery. […] Prednisone plus colchicine has a similar efficacy to prednisone plus tamoxifen for the initial and long-term treatment of sclerosing mesenteritis. […] The majority of patients were initiated on medical therapy over the long term with most reporting symptomatic improvement within a year.

• #26 Sclerosing mesenteritis | Radiology Reference Article | Radiopaedia.org

  https://radiopaedia.org/articles/sclerosing-mesenteritis-1?lang=us

  The mainstay of treatment is supportive, as the disease is typically self-limiting. If severe or protracted, medical therapy with corticosteroids, cyclophosphamide or azathioprine can be contemplated. Mesenteric panniculitis cannot be completely resected and surgery is of no benefit. […] While local lymphoma (in up to 15% of cases), and a more general association with malignancy of 37-56% have been suggested, but a true association has not been proved. In patients diagnosed with mesenteric panniculitis, lymphadenopathy 12 mm, and absence of a 'fat halo’ around lymph nodes and vessels increased the risk of subsequent malignancy diagnosis in one study. Limitations of studies suggesting a malignancy association have been highlighted, and contrary evidence including a systematic review and meta-analysis, and case matched cohort studies have dismissed such an association.

• #27 Idiopathic sclerosing mesenteritis in the pediatric patient: A case report | Revista de Gastroenterología de México

  https://www.revistagastroenterologiamexico.org/en-idiopathic-sclerosing-mesenteritis-in-pediatric-articulo-S2255534X14000024

  Sclerosing mesenteritis makes up part of a spectrum of rare idiopathic conditions characterized by chronic inflammation of the mesentery and fibrosis. Clinical presentation varies from an asymptomatic abdominal mass to acute systemic syndromes manifested as fever, weight loss, general malaise, bowel obstruction, or intestinal ischemia. […] Few patients require surgical treatment, which is generally directed at secondary complications such as bowel obstruction. […] Systemic steroid therapy was begun, along with isoniazid for 9 months for treating the latent tuberculosis infection. Due to the severity of the clinical symptoms, cyclophosphamide was added. Once treatment was started, the patient progressed adequately, he tolerated oral intake, there were no febrile peaks, and the ascites and distension were resolved.

• #28 Sclerosing Mesenteritis-Update on Diagnostic and Therapeutic Appr

  https://www.itmedicalteam.pl/articles/sclerosing-mesenteritisupdate-on-diagnostic-and-therapeutic-approach-108510.html

  There is no specific treatment for SM and should this be empirical and individualized. […] Although they are described cases of spontaneous remission, some authors have shown benefit with the empirical treatment using corticosteroids, colchicine, immunosuppressants, antibiotics, tamoxifen, alone or in combination. […] The clinical management depends on the histological findings and stage of the disease. In the early stages, when fat necrosis is the main feature, it tends to settle spontaneously without. […] As the disease progresses and chronic inflammation with or without fibrosis predominates, various agents have been used alone or in combination. Treatment has been attempted with a variety of drugs including steroids, azathioprine, cyclophosphamide, colchicine, tamoxifen, or radiotherapy, with different degrees of success.

• #29 Idiopathic sclerosing mesenteritis – Wikipedia

  https://en.wikipedia.org/wiki/Idiopathic_sclerosing_mesenteritis

  Corticosteroids may be used. […] In terms of possible treatment for the condition of idiopathic sclerosing mesenteritis, medications such as corticosteroids, tamoxifen and thalidomide have been used. […] In that case series, 56% of patients received only pharmacological therapy, most often receiving tamoxifen with a reducing dose of reducing prednisone, or also had colchicine, azathioprine or thalidomide. […] Symptomatic patients benefited from medical therapy, usually tamoxifen and prednisone, but further follow-up information would strengthen these results.

• #30 Sclerosing Mesenteritis-Update on Diagnostic and Therapeutic Appr

  https://www.itmedicalteam.pl/articles/sclerosing-mesenteritisupdate-on-diagnostic-and-therapeutic-approach-108510.html

  Some cases have been related reports successful role of colchicine therapy in the maintenance of remission of mesenteric panniculitis. […] Pentoxyfylline has been recently reported the promising antifibrotic agent successfully used in a case of sclerosing mesenteritis. […] The surgical approach should be limited to biopsy of the mass. […] Therefore, surgery should be attempted only in patients with severe complications, such as bowel obstruction or perforation and advanced inflammatory changes irreversible. […] Although there is uncertainty about the optimal treatment, it is a situation with a favorable prognosis in most patients with good responses to treatment.

• #31

  https://journals.lww.com/ajg/fulltext/2014/10002/treatment_outcomes_from_pentoxifylline_in.403.aspx

  Pentoxifylline appears to be a reasonable treatment option for patients with SM that did not respond to tamoxifen. […] It appears to be well-tolerated, with only 1 patient stopping due to side effects. […] However, larger studies are necessary to better estimate the benefits and side effect profile of pentoxifylline in SM.

• #32

  https://journals.lww.com/ajg/fulltext/2024/10001/s2970_treatment_of_immune_checkpoint_inhibitor.2971.aspx

  Sclerosing mesenteritis (SM) is a rare condition involving nonspecific inflammation and fibrosis of mesenteric fat. […] We report 2 cases: one achieving remission with tamoxifen after corticosteroid failure, and another improving with ustekinumab, an interleukin-12 and -23 antagonist, after failing both corticosteroids and tamoxifen. […] Initiation of tamoxifen and ustekinumab led to clinical and radiological remission within 1 month. Ustekinumab, effective in other inflammatory conditions, demonstrated efficacy in achieving remission when both corticosteroids and tamoxifen failed. […] These findings suggest that tamoxifen and ustekinumab could be valuable treatment options for ICI-induced SM, contributing to the growing evidence supporting targeted cytokine inhibition in managing this complex condition.

• #33

  https://link.springer.com/article/10.1007/s10620-021-07081-4

  Sclerosing mesenteritis is a rare condition characterized by chronic inflammation and fibrotic changes of the mesentery. […] Prednisone plus colchicine has a similar efficacy to prednisone plus tamoxifen for the initial and long-term treatment of sclerosing mesenteritis. […] The majority of patients were initiated on medical therapy over the long term with most reporting symptomatic improvement within a year.

• #34 A Clinical Review of Mesenteric Panniculitis – Gastroenterology & Hepatology

  https://www.gastroenterologyandhepatology.net/archives/april-2023/a-clinical-review-of-mesenteric-panniculitis/

  Considering the benign nature of MP, therapeutic decisions should be guided by the severity of symptoms and presence of complications. Asymptomatic patients who present with MP as an incidental finding do not need to be started on treatment. […] In this case series, which is the largest one published to date, medical treatment of tamoxifen twice daily and a prednisone taper over 3 months was administered in 20 patients. Of these, 12 (60%) responded to therapy within 12 to 16 weeks, with 6 patients (30%) having persistent symptoms and 2 patients (10%) showing disease progression. […] A recently published retrospective study by Cortés and colleagues that determined the long-term management outcomes of 103 patients with biopsy-proven MP concluded that prednisone plus colchicine has a similar efficacy to prednisone plus tamoxifen for the initial treatment and 14-month follow-up of MP.

• #35 Treatment options for spontaneous and postoperative sclerosing mesenteritis

  https://www.wjgnet.com/1948-9366/full/v8/i11/761.htm

  Sclerosing mesenteritis is a rare pathology with only a few described cases in the literature. […] So far there are no distinct treatment algorithms, so the patients were treated differently, including steroids, antibiotics and watchful waiting. […] In addition, we reviewed the current literature on treatment options for this rare disease. […] The only evidence in the treatment of these patients is that, in the case of non-resolving bowel obstruction, surgery is needed. […] Several therapeutic approaches with agents such as steroids, colchicine and azathioprine have been described with various therapeutic effects. […] However, the symptomatic sclerosing mesenteritis must be treated surgically or with a trial of immunosuppressive medication. […] The only evidence is that in the case of non-resolving bowel obstruction or an advanced inflammatory reaction, surgical resection is needed.

• #36 Frontiers | Sclerosing Mesenteritis, a Rare Cause of Mesenteric Mass in a Young Adult: A Case Report

  https://www.frontiersin.org/journals/surgery/articles/10.3389/fsurg.2021.722312/full

  Sclerosing mesenteritis (SM) is a rare fibroinflammatory disorder that involves mesenteric adipose tissue, more frequently localized in the small intestine, with an insidious clinical presentation having symptoms related to mass effect, usually resulting in bowel obstruction, mesenteric ischemia, as well as rapid weight loss. […] The diagnosis of sclerosing mesenteritis was made. […] In cases where obstructive symptoms prevail, as in our patient, surgical excision is mandatory. […] No consensus has been reached regarding the management of SM; as far as medical treatments are concerned, the use of corticosteroids, tamoxifen, thalidomide, colchicine, infliximab, azathioprine, and cyclophosphamide has been proposed with variable results. […] The prognosis of SM is generally excellent, with the painful symptoms subsiding and the mass reducing in size in most patients.

• #37 Sclerosing mesenteritis – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/sclerosing-mesenteritis/diagnosis-treatment/drc-20450343

  You may be diagnosed with sclerosing mesenteritis while you are receiving care for another condition. If you are not experiencing discomfort from sclerosing mesenteritis, you may not need treatment. Instead, occasional imaging tests may be recommended to monitor your condition. […] If you begin to experience symptoms of sclerosing mesenteritis, you may choose to begin treatment. […] Medicines for sclerosing mesenteritis are used to control inflammation. Medicines may include: […] Corticosteroids such as prednisone control inflammation. Corticosteroids can be used alone but are usually combined with other medicines. They are not generally used for more than 3 to 4 months because of side effects. […] Hormone treatments such as tamoxifen (Soltamox) may slow the growth of scar tissue. Tamoxifen is typically combined with corticosteroids or other medicines and may be used long term. Tamoxifen increases the risk of blood clots and is typically combined with a daily aspirin to reduce this risk. Progesterone (Prometrium) may be used as an alternative to tamoxifen, but it also has significant side effects. […] Several other medicines have been used to treat sclerosing mesenteritis, such as azathioprine (Imuran, Azasan), colchicine (Colcrys, Mitigare), cyclophosphamide and thalidomide (Thalomid). […] You may need surgery if the scar tissue blocks food from moving through your digestive tract.

• #38 Sclerosing mesenteritis

  https://www.mymlc.com/health-information/diseases-and-conditions/s/sclerosing-mesenteritis/

  Hormone treatments such as tamoxifen may slow the growth of scar tissue. Tamoxifen (Soltamox) is typically combined with corticosteroids or other medications and may be used long term. […] If sclerosing mesenteritis advances to block the flow of food through your digestive system, you may need surgery to remove the blockage.

• #39 Idiopathic Sclerosing Mesenteritis: An Extremely Rare Cause of Mesenteric Mass | Dhruv | Journal of Medical Cases

  https://www.journalmc.org/index.php/JMC/article/view/3825/3177

  Idiopathic sclerosing mesenteritis (ISM) is an extremely rare condition in which mesenteric adipose tissue undergoes necrotic and fibrotic changes. […] Most cases are either self-limiting or improve with medical therapy. However, aggressive cases requiring emergent surgical interventions to relieve intestinal obstruction have been reported in the literature. […] Due to the non-specific nature of biopsies and continued pain, diagnostic and therapeutic laparoscopy was performed which showed a large abscess cavity in the base of transverse colon, mesentery, and the loop of small bowel. Abscess cavity was drained with removal of inflammatory mass and necrotic tissue, and small bowel was separated. […] Literature review suggests these patients respond to the combination of corticosteroid and tamoxifen when symptomatic in most cases. Other immunosuppressive agents such as infliximab, cyclosporine and azathioprine have also been used with successful outcomes.

• #40 Sclerosing Mesenteritis-Update on Diagnostic and Therapeutic Appr

  https://www.itmedicalteam.pl/articles/sclerosing-mesenteritisupdate-on-diagnostic-and-therapeutic-approach-108510.html

  Some cases have been related reports successful role of colchicine therapy in the maintenance of remission of mesenteric panniculitis. […] Pentoxyfylline has been recently reported the promising antifibrotic agent successfully used in a case of sclerosing mesenteritis. […] The surgical approach should be limited to biopsy of the mass. […] Therefore, surgery should be attempted only in patients with severe complications, such as bowel obstruction or perforation and advanced inflammatory changes irreversible. […] Although there is uncertainty about the optimal treatment, it is a situation with a favorable prognosis in most patients with good responses to treatment.

• #41 Sclerosing mesenteritis mimicking metachronous peritoneal metastases from descending colon adenocarcinoma | World Journal of Surgical Oncology | Full Text

  https://wjso.biomedcentral.com/articles/10.1186/s12957-017-1214-4

  Sclerosing mesenteritis is sometimes indistinguishable from neoplasms because its manifestations and radiographic findings may be identical to those of malignancies. […] Despite these similarities, sclerosing mesenteritis is treated very differently than malignancies; thus, it is very important that sclerosing mesenteritis is diagnosed correctly so that the disease can be managed adequately. […] The prognosis of sclerosing mesenteritis is generally regarded as favorable with supportive treatment. […] In conclusion, it is necessary to excise and examine mesenteric nodules in patients with a history of malignancy to distinguish tumor recurrence from alternative diagnoses, such as sclerosing mesenteritis. […] Sclerosing mesenteritis can mimic peritoneal metastasis from malignancies, and it is necessary to excise and examine a mesenteric nodule developing in patients with a history of malignancy to distinguish recurrence and differential diagnosis such as sclerosing mesenteritis.

• #42 Sclerosing mesenteritis | Radiology Reference Article | Radiopaedia.org

  https://radiopaedia.org/articles/sclerosing-mesenteritis-1?lang=us

  The mainstay of treatment is supportive, as the disease is typically self-limiting. If severe or protracted, medical therapy with corticosteroids, cyclophosphamide or azathioprine can be contemplated. Mesenteric panniculitis cannot be completely resected and surgery is of no benefit. […] While local lymphoma (in up to 15% of cases), and a more general association with malignancy of 37-56% have been suggested, but a true association has not been proved. In patients diagnosed with mesenteric panniculitis, lymphadenopathy 12 mm, and absence of a 'fat halo’ around lymph nodes and vessels increased the risk of subsequent malignancy diagnosis in one study. Limitations of studies suggesting a malignancy association have been highlighted, and contrary evidence including a systematic review and meta-analysis, and case matched cohort studies have dismissed such an association.

• #43 A Clinical Review of Mesenteric Panniculitis – Gastroenterology & Hepatology

  https://www.gastroenterologyandhepatology.net/archives/april-2023/a-clinical-review-of-mesenteric-panniculitis/

  Alternatively, other agents have been described for the treatment of MP, especially in patients who do not initially respond to conventional treatment regimens. These nonconventional medications include pentoxifylline, raloxifene, immunomodulators (azathioprine, methotrexate, 6-mercaptopurine), cyclophosphamide, sulfasalazine, thalidomide, lenalidomide, and monoclonal antibodies (infliximab, rituximab). […] Given the self-limited course of this condition, it would appear reasonable to avoid surgical intervention beyond diagnostic sampling. In one recent series, only 5 of 103 (4.9%) patients were treated surgically, which included bowel resection or lysis of adhesions for the management of small bowel obstruction.

• #44 Sclerosing mesenteritis:an uncommon cause of chronic abdominal pain – MedCrave online

  https://medcraveonline.com/GHOA/sclerosing-mesenteritisan-uncommon-cause-of-chronic-abdominal-pain.html

  A treatment algorithm was prepared by Akram after review on 92 cases. Asymptomatic patients with incidental diagnosis do not need treatment. Patients with features of bowel obstruction need to undergo surgical treatment followed by tamoxifen plus tapering dose of steroids if there is persistence of symptoms. […] For patients who are contraindicated for tamoxifen especially due to thromboembolism should be treated with colchicine, azathioprine or thalidomide. […] Finally, SM is a rare cause of chronic abdominal pain. Though most of the cases are benign like ours, they can be associated with underlying malignancy which need to be ruled out. There are no specific guidelines for treatment of SM till date. Further studies are required to formulate specific guidelines for the treatment of SM for which our case could add value.

• #45 Ultrasonography-based Management of Sclerosing Mesenteritis | IMCRJ

  https://www.dovepress.com/ultrasonography-based-management-of-sclerosing-mesenteritis-from-diagn-peer-reviewed-fulltext-article-IMCRJ

  Sclerosing mesenteritis (SM) is an idiopathic disorder affecting mesentery, characterized by fat necrosis, chronic inflammation and fibrosis. […] In the absence of clinical trials, the treatment of SM is empirical and ranges, according to clinical presentation, from simple observation to corticosteroids, immunosuppressive drugs, hormonal therapy or surgery. […] Danford et al proposed a therapeutic algorithm, in which patients are divided into asymptomatic and symptomatic; while the first group are only observed, the second group (the symptomatic group) receive treatment. The first line therapy consists of the use of steroids (prednisone 40 mg/daily tapered slowly) in combination with tamoxifen 10 mg twice daily. […] In our case, the patient was effectively treated using steroids plus tamoxifen. […] In conclusion, US could be a sensitive, reliable and non-invasive procedure for the diagnosis and the follow-up of SM.

• #46 Sclerosing mesenteritis:an uncommon cause of chronic abdominal pain – MedCrave online

  https://medcraveonline.com/GHOA/sclerosing-mesenteritisan-uncommon-cause-of-chronic-abdominal-pain.html

  A treatment algorithm was prepared by Akram after review on 92 cases. Asymptomatic patients with incidental diagnosis do not need treatment. Patients with features of bowel obstruction need to undergo surgical treatment followed by tamoxifen plus tapering dose of steroids if there is persistence of symptoms. […] For patients who are contraindicated for tamoxifen especially due to thromboembolism should be treated with colchicine, azathioprine or thalidomide. […] Finally, SM is a rare cause of chronic abdominal pain. Though most of the cases are benign like ours, they can be associated with underlying malignancy which need to be ruled out. There are no specific guidelines for treatment of SM till date. Further studies are required to formulate specific guidelines for the treatment of SM for which our case could add value.

• #47 Ultrasonography-based Management of Sclerosing Mesenteritis | IMCRJ

  https://www.dovepress.com/ultrasonography-based-management-of-sclerosing-mesenteritis-from-diagn-peer-reviewed-fulltext-article-IMCRJ

  Sclerosing mesenteritis (SM) is an idiopathic disorder affecting mesentery, characterized by fat necrosis, chronic inflammation and fibrosis. […] In the absence of clinical trials, the treatment of SM is empirical and ranges, according to clinical presentation, from simple observation to corticosteroids, immunosuppressive drugs, hormonal therapy or surgery. […] Danford et al proposed a therapeutic algorithm, in which patients are divided into asymptomatic and symptomatic; while the first group are only observed, the second group (the symptomatic group) receive treatment. The first line therapy consists of the use of steroids (prednisone 40 mg/daily tapered slowly) in combination with tamoxifen 10 mg twice daily. […] In our case, the patient was effectively treated using steroids plus tamoxifen. […] In conclusion, US could be a sensitive, reliable and non-invasive procedure for the diagnosis and the follow-up of SM.

• #48 Research forges path to effective treatment for sclerosing mesenteritis – Mayo Clinic News Network

  https://newsnetwork.mayoclinic.org/discussion/research-forges-path-to-effective-treatment-for-sclerosing-mesenteritis/

  One of the more serious complications of SM is the growth of masses that encase the mesenteric artery. […] Thus far, Carol’s SM has been managed with medications. […] „Learning to manage your pain is crucial,” says Carol. […] „There’s no one answer to how to change diet,” says Dr. Pardi. […] „You make adjustments that can only be made with the help of a support system,” she insists. […] „If there’s a frontier for SM research, the frontier is here at Mayo. If there’s a new treatment that develops, I know I’ll have access to it here.”

• #49 Ultrasonography-based Management of Sclerosing Mesenteritis | IMCRJ

  https://www.dovepress.com/ultrasonography-based-management-of-sclerosing-mesenteritis-from-diagn-peer-reviewed-fulltext-article-IMCRJ

  Sclerosing mesenteritis (SM) is an idiopathic disorder affecting mesentery, characterized by fat necrosis, chronic inflammation and fibrosis. […] In the absence of clinical trials, the treatment of SM is empirical and ranges, according to clinical presentation, from simple observation to corticosteroids, immunosuppressive drugs, hormonal therapy or surgery. […] Danford et al proposed a therapeutic algorithm, in which patients are divided into asymptomatic and symptomatic; while the first group are only observed, the second group (the symptomatic group) receive treatment. The first line therapy consists of the use of steroids (prednisone 40 mg/daily tapered slowly) in combination with tamoxifen 10 mg twice daily. […] In our case, the patient was effectively treated using steroids plus tamoxifen. […] In conclusion, US could be a sensitive, reliable and non-invasive procedure for the diagnosis and the follow-up of SM.

• #50 Frontiers | Sclerosing Mesenteritis, a Rare Cause of Mesenteric Mass in a Young Adult: A Case Report

  https://www.frontiersin.org/journals/surgery/articles/10.3389/fsurg.2021.722312/full

  Sclerosing mesenteritis (SM) is a rare fibroinflammatory disorder that involves mesenteric adipose tissue, more frequently localized in the small intestine, with an insidious clinical presentation having symptoms related to mass effect, usually resulting in bowel obstruction, mesenteric ischemia, as well as rapid weight loss. […] The diagnosis of sclerosing mesenteritis was made. […] In cases where obstructive symptoms prevail, as in our patient, surgical excision is mandatory. […] No consensus has been reached regarding the management of SM; as far as medical treatments are concerned, the use of corticosteroids, tamoxifen, thalidomide, colchicine, infliximab, azathioprine, and cyclophosphamide has been proposed with variable results. […] The prognosis of SM is generally excellent, with the painful symptoms subsiding and the mass reducing in size in most patients.

• #51 Sclerosing Mesenteritis-Update on Diagnostic and Therapeutic Appr

  https://www.itmedicalteam.pl/articles/sclerosing-mesenteritisupdate-on-diagnostic-and-therapeutic-approach-108510.html

  Some cases have been related reports successful role of colchicine therapy in the maintenance of remission of mesenteric panniculitis. […] Pentoxyfylline has been recently reported the promising antifibrotic agent successfully used in a case of sclerosing mesenteritis. […] The surgical approach should be limited to biopsy of the mass. […] Therefore, surgery should be attempted only in patients with severe complications, such as bowel obstruction or perforation and advanced inflammatory changes irreversible. […] Although there is uncertainty about the optimal treatment, it is a situation with a favorable prognosis in most patients with good responses to treatment.

• #52 Sclerosing mesenteritis: clinical features, treatment, and outcome in ninety-two patients – PubMed

  https://pubmed.ncbi.nlm.nih.gov/17478346/

  Sclerosing mesenteritis is a rare non-neoplastic disease that affects the small bowel mesentery with chronic fibrosing inflammation. There are few data on the natural history and therapeutic options for this condition. […] Treatment included medical therapy alone in 26%, surgery alone in 13%, surgery followed by medical therapy in 9%, and 52% received no treatment. Ten percent responded to surgery alone, 20% responded to additional medical treatment after surgery, and 38% responded to medical therapy alone. Tamoxifen in combination with prednisone was used in 20 patients, and 60% improved. Non-tamoxifen-based regimens were used in 12 patients, and 8% improved. […] Our results suggest that symptomatic patients might benefit from medical therapy, particularly tamoxifen and prednisone combination treatment. Long-term follow-up is needed to substantiate these results.

• #53 IgG4-Related Sclerosing Mesenteritis

  https://www.jpatholtm.org/journal/view.php?doi=10.4132/jptm.2015.12.03

  Sclerosing mesenteritis (SM) is a rare disease first described by Sulla in 1924 under the name retractile mesenteritis. […] There is no generalized consensus regarding the treatment of SM, including medical therapy, surgical therapy, and surgery with additional medical therapy. […] Even, when patients with SM are not treated, they show a high rate of spontaneous resolution. Therefore, therapy is needed when a patient displays symptoms. […] In summary, we present a case of IgG4-RSM, which is compatible with previously described cases. The condition is benign and has a self-limiting course, but the pathologic diagnosis is important to exclude malignant conditions, which can be misdiagnosed on radiologic analysis. The rarity of the disease limits its clear characterization, and more cases and studies are needed.

• #54 Sclerosing mesenteritis as an unusual cause of fever of unknown origin: a case report and review | Clinics

  https://www.elsevier.es/en-revista-clinics-22-articulo-sclerosing-mesenteritis-as-an-unusual-S1807593222018683

  Sclerosing mesenteritis is a rare idiopathic condition characterized by a non-neoplastic inflammatory process in the mesenteric fat. […] The best treatment for sclerosing mesenteritis remains unclear. Asymptomatic or mild clinical forms may sometimes be left untreated with spontaneous recovery. Surgical resection is required for patients with intestinal obstruction and perforation, and immunosuppressive therapy with corticosteroids, thalidomide, and other drugs has been recommended by some authors. […] In the present case, surgical removal was able to limit the process. The prognosis is mainly dependent on a correct diagnosis and on the extension of the fibrotic process.

• #55

  https://www.ijsurgery.com/index.php/isj/article/view/14

  The diagnosis is established by histopathologic study. There is no specific treatment for SM and should this be empirical and individualized. […] Although they are described cases of spontaneous remission, some authors have shown benefit with the empirical treatment using corticosteroids, colchicine, immunosuppressants, antibiotics, tamoxifen, alone or in combination. The surgical approach has a limited role and usually aimed at symptomatic relief. In most cases, the prognosis is favorable.

• #56 Mesenteric panniculitis: Various presentations and treatment regimens

  https://www.wjgnet.com/1007-9327/full/v15/i30/3827.htm

  In conclusion, mesenteric panniculitis is a rare clinical entity that occurs independently or in association with other disorders. Diagnosis of this nonspecific, benign inflammatory disease is a challenge to gastroenterologists, radiologists, surgeons and pathologists. There is no standardized treatment, and it may consist of anti-inflammatory or immunosuppressive agents.

• #57 Sclerosing mesenteritis: clinical features, treatment, and outcome in ninety-two patients – PubMed

  https://pubmed.ncbi.nlm.nih.gov/17478346/

  Sclerosing mesenteritis is a rare non-neoplastic disease that affects the small bowel mesentery with chronic fibrosing inflammation. There are few data on the natural history and therapeutic options for this condition. […] Treatment included medical therapy alone in 26%, surgery alone in 13%, surgery followed by medical therapy in 9%, and 52% received no treatment. Ten percent responded to surgery alone, 20% responded to additional medical treatment after surgery, and 38% responded to medical therapy alone. Tamoxifen in combination with prednisone was used in 20 patients, and 60% improved. Non-tamoxifen-based regimens were used in 12 patients, and 8% improved. […] Our results suggest that symptomatic patients might benefit from medical therapy, particularly tamoxifen and prednisone combination treatment. Long-term follow-up is needed to substantiate these results.

• #58 Idiopathic sclerosing mesenteritis – Wikipedia

  https://en.wikipedia.org/wiki/Idiopathic_sclerosing_mesenteritis

  Corticosteroids may be used. […] In terms of possible treatment for the condition of idiopathic sclerosing mesenteritis, medications such as corticosteroids, tamoxifen and thalidomide have been used. […] In that case series, 56% of patients received only pharmacological therapy, most often receiving tamoxifen with a reducing dose of reducing prednisone, or also had colchicine, azathioprine or thalidomide. […] Symptomatic patients benefited from medical therapy, usually tamoxifen and prednisone, but further follow-up information would strengthen these results.

• #59 Idiopathic Sclerosing Mesenteritis: An Extremely Rare Cause of Mesenteric Mass | Dhruv | Journal of Medical Cases

  https://www.journalmc.org/index.php/JMC/article/view/3825/3177

  Overall, most patients will improve over time and if it is secondary to autoimmune conditions, the treatment of the autoimmune condition improves the inflammation in the mesentery. […] Tamoxifen and prednisone have been used for treatment with successful outcomes in most cases. […] Further research is needed to establish the etiology of the disease and proper treatment protocols including medical vs. surgical management and their respective outcomes.

• #60 Sclerosing mesenteritis:an uncommon cause of chronic abdominal pain – MedCrave online

  https://medcraveonline.com/GHOA/sclerosing-mesenteritisan-uncommon-cause-of-chronic-abdominal-pain.html

  A treatment algorithm was prepared by Akram after review on 92 cases. Asymptomatic patients with incidental diagnosis do not need treatment. Patients with features of bowel obstruction need to undergo surgical treatment followed by tamoxifen plus tapering dose of steroids if there is persistence of symptoms. […] For patients who are contraindicated for tamoxifen especially due to thromboembolism should be treated with colchicine, azathioprine or thalidomide. […] Finally, SM is a rare cause of chronic abdominal pain. Though most of the cases are benign like ours, they can be associated with underlying malignancy which need to be ruled out. There are no specific guidelines for treatment of SM till date. Further studies are required to formulate specific guidelines for the treatment of SM for which our case could add value.

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