Materiały źródłowe

• #1 Sclerosing mesenteritis: a comprehensive clinical review

  https://atm.amegroups.org/article/view/20473/html

  Sclerosing mesenteritis is a rare disease entity initially described in 1924 with a prevalence reported to be less than 1%. […] The etiology of sclerosing mesenteritis is uncertain, but the disease has been associated with trauma, autoimmune disease, surgery, and malignancy. […] At least four different pathologic processes have been proposed as etiologies of development of sclerosing mesenteritis including abdominal surgery/trauma, autoimmune phenomenon, paraneoplastic process, and ischemia/infection. […] Abdominal surgery has frequently been shown to be a precursor to the development of sclerosing mesenteritis. […] Role of autoimmunity as an etiology of sclerosing mesenteritis has been purported by several authors. […] One of the single biggest debate pertaining to sclerosing mesenteritis has been the question of whether sclerosing mesenteritis is a paraneoplastic syndrome. […] Although infection has been proposed as one of the mechanisms of sclerosing mesenteritis development, there has been very little evidence provided in the published case series or large retrospective chart reviews.

• #2 Sclerosing mesenteritis – Symptoms and causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/sclerosing-mesenteritis/symptoms-causes/syc-20355087

  Sclerosing mesenteritis is a condition in which tissue that holds the small intestines in place, called the mesentery, becomes inflamed and forms scar tissue. […] Sclerosing mesenteritis is rare, and it’s not clear what causes it. […] The cause of sclerosing mesenteritis is not known.

• #3 Sclerosing mesenteritis: a comprehensive clinical review

  https://atm.amegroups.org/article/view/20473/html

  Sclerosing mesenteritis is a rare disease entity initially described in 1924 with a prevalence reported to be less than 1%. […] The etiology of sclerosing mesenteritis is uncertain, but the disease has been associated with trauma, autoimmune disease, surgery, and malignancy. […] At least four different pathologic processes have been proposed as etiologies of development of sclerosing mesenteritis including abdominal surgery/trauma, autoimmune phenomenon, paraneoplastic process, and ischemia/infection. […] Abdominal surgery has frequently been shown to be a precursor to the development of sclerosing mesenteritis. […] Role of autoimmunity as an etiology of sclerosing mesenteritis has been purported by several authors. […] One of the single biggest debate pertaining to sclerosing mesenteritis has been the question of whether sclerosing mesenteritis is a paraneoplastic syndrome. […] Although infection has been proposed as one of the mechanisms of sclerosing mesenteritis development, there has been very little evidence provided in the published case series or large retrospective chart reviews.

• #4 Sclerosing Mesenteritis: A Rare Cause of Abdominal Pain

  https://pmc.ncbi.nlm.nih.gov/articles/PMC9520956/

  Sclerosing mesenteritis (SM) is a rare inflammatory fibrotic disease of the small intestine mesenteric fat often discovered incidentally on a CT scan. […] SM is more common in men than women with a ratio of 2:1. It mostly occurs during the fifth to seventh decades of life, with a patients median age of 65 years. […] Besides cancer, SM is associated with other conditions that have been suggested as possible causes, such as previous abdominal surgery or trauma, autoimmune disease, abdominal aortic aneurysm, and infection, but at this time the etiology is unknown. […] There are some reports of SM being a paraneoplastic syndrome but there is conflicting data. […] The most common cancers in this series were lymphoma, melanoma, colon, and prostate two of which were present in our patient. […] A CT scan case-control study by van Putte-Katier et al. showed a significant increase in cancer with lymphoma being the third highest in prevalence. […] A heightened awareness of this disease may prompt further evaluation, especially in patients with more severe or uncontrolled symptoms.

• #5 Sclerosing mesenteritis: a comprehensive clinical review

  https://atm.amegroups.org/article/view/20473/html

  Sclerosing mesenteritis is a rare disease entity initially described in 1924 with a prevalence reported to be less than 1%. […] The etiology of sclerosing mesenteritis is uncertain, but the disease has been associated with trauma, autoimmune disease, surgery, and malignancy. […] At least four different pathologic processes have been proposed as etiologies of development of sclerosing mesenteritis including abdominal surgery/trauma, autoimmune phenomenon, paraneoplastic process, and ischemia/infection. […] Abdominal surgery has frequently been shown to be a precursor to the development of sclerosing mesenteritis. […] Role of autoimmunity as an etiology of sclerosing mesenteritis has been purported by several authors. […] One of the single biggest debate pertaining to sclerosing mesenteritis has been the question of whether sclerosing mesenteritis is a paraneoplastic syndrome. […] Although infection has been proposed as one of the mechanisms of sclerosing mesenteritis development, there has been very little evidence provided in the published case series or large retrospective chart reviews.

• #6 Sclerosing Mesenteritis-Update on Diagnostic and Therapeutic Appr

  https://www.itmedicalteam.pl/articles/sclerosing-mesenteritisupdate-on-diagnostic-and-therapeutic-approach-108510.html

  The etiology of SM remains unknown, although several mechanisms have been suggested contributors, including surgery or abdominal trauma before, autoimmunity, paraneoplastic syndrome, ischemic injury and infections. […] The SM has unknown etiology and can occur independently or in association with other disorders. […] Various mechanisms are being suggested based on case reports and animal studies. Among them, include abdominal trauma, previous surgery, autoimmune diseases, ischemic injury, and paraneoplastic syndromes, infections. […] The SM has been described in association with a number of conditions, including autoimmune thyroiditis, presumably of Riedel, primary sclerosing cholangitis, retroperitoneal fibrosis, and orbital pseudotumor. […] The ischemic lesions are described correlated with the previous surgery, abdominal trauma, mesenteric thrombosis and mesenteric arteriopathy.

• #7 Sclerosing mesenteritis: a comprehensive clinical review

  https://atm.amegroups.org/article/view/20473/html

  Sclerosing mesenteritis is a rare disease entity initially described in 1924 with a prevalence reported to be less than 1%. […] The etiology of sclerosing mesenteritis is uncertain, but the disease has been associated with trauma, autoimmune disease, surgery, and malignancy. […] At least four different pathologic processes have been proposed as etiologies of development of sclerosing mesenteritis including abdominal surgery/trauma, autoimmune phenomenon, paraneoplastic process, and ischemia/infection. […] Abdominal surgery has frequently been shown to be a precursor to the development of sclerosing mesenteritis. […] Role of autoimmunity as an etiology of sclerosing mesenteritis has been purported by several authors. […] One of the single biggest debate pertaining to sclerosing mesenteritis has been the question of whether sclerosing mesenteritis is a paraneoplastic syndrome. […] Although infection has been proposed as one of the mechanisms of sclerosing mesenteritis development, there has been very little evidence provided in the published case series or large retrospective chart reviews.

• #8 Sclerosing mesenteritis – UpToDate

  https://www.uptodate.com/contents/sclerosing-mesenteritis/print

  Sclerosing mesenteritis is a rare, non-neoplastic inflammatory and fibrotic disease that affects the mesentery. […] The pathogenesis of sclerosing mesenteritis remain unclear, although several mechanisms have been postulated. […] It is hypothesized that sclerosing mesenteritis results in genetically predisposed individuals who have abnormal responses to healing and repair of connective tissue in response to trauma. […] In a systematic review of the published literature, previous abdominal surgery or abdominal trauma was described in almost 30 percent of patients. […] Sclerosing mesenteritis has been reported in association with both acute abdominal injury and chronic repetitive trauma (eg, pneumatic jackhammer) and inflammation (eg, occult ileal perforation). […] The use of powdered surgical gloves has also been implicated in the development of abdominal fibrosis as a precursor to sclerosing mesenteritis.

• #9 Sclerosing Mesenteritis: A Review Article | Insight Medical Publishing

  https://raredisorders.imedpub.com/articles/sclerosing-mesenteritis-a-review-article.php?aid=23602

  Sclerosing mesenteritis is a rare chronic inflammatory condition characterized by mesenteric fibrosis. […] The etiology of sclerosis mesenteritis (SM) is unknown. […] A systematic review by Sharma et al. in 2017 reported that approximately 30% of patients had a history of prior abdominal surgery or trauma. […] Other potential causative factors include infection, ischemia, and neoplasm. […] Autoimmune conditions associated with SM include retroperitoneal fibrosis, sclerosing cholangitis, Riedel thyroiditis, and orbital pseudotumor. […] The pathophysiology of SM is likewise unclear. […] Given the typical presence of foamy macrophages on histopathology, it has been hypothesized that molecular pathways involving foam cell formation, including upregulation of peroxisome proliferator-activated receptor-gamma (PPAR-gamma), may play a role. […] A recent small series of case reports further suggests a relationship between dysfunctional glucose metabolism and the molecular mechanism of SM.

• #10 IgG4-related sclerosing mesenteritis causing bowel obstruction: a case report | Surgical Case Reports | Full Text

  https://surgicalcasereports.springeropen.com/articles/10.1186/s40792-016-0248-0

  Sclerosing mesenteritis (SM) is a rare inflammatory and fibrosing disease primarily involving the small-bowel mesentery. […] The etiology of SM remains undetermined. Suggested causes include trauma (including surgery), powder on surgical gloves, infection (such as tuberculosis), autoimmune diseases, vascular insufficiency, and retained suture material. […] About 40 to 70 % of patients with SM were found to have undergone previous surgery. […] The pathogenic mechanism of SM seems to be a non-specific response to a wide variety of stimuli. […] SM may be an IgG4-RD, diseases that dramatically respond to corticosteroid treatment. […] Although the incidence of SM related to IgG4-RD has not been determined, SM was observed in 2 (4 %) of 57 patients with autoimmune pancreatitis and marked infiltration of IgG4-positive plasma cells was observed in 4 (33 %) of 12 patients with SM.

• #11 Sclerosing mesenteritis – UpToDate

  https://www.uptodate.com/contents/sclerosing-mesenteritis/print

  Sclerosing mesenteritis is a rare, non-neoplastic inflammatory and fibrotic disease that affects the mesentery. […] The pathogenesis of sclerosing mesenteritis remain unclear, although several mechanisms have been postulated. […] It is hypothesized that sclerosing mesenteritis results in genetically predisposed individuals who have abnormal responses to healing and repair of connective tissue in response to trauma. […] In a systematic review of the published literature, previous abdominal surgery or abdominal trauma was described in almost 30 percent of patients. […] Sclerosing mesenteritis has been reported in association with both acute abdominal injury and chronic repetitive trauma (eg, pneumatic jackhammer) and inflammation (eg, occult ileal perforation). […] The use of powdered surgical gloves has also been implicated in the development of abdominal fibrosis as a precursor to sclerosing mesenteritis.

• #12 Sclerosing mesenteritis – UpToDate

  https://www.uptodate.com/contents/sclerosing-mesenteritis/print

  Sclerosing mesenteritis is a rare, non-neoplastic inflammatory and fibrotic disease that affects the mesentery. […] The pathogenesis of sclerosing mesenteritis remain unclear, although several mechanisms have been postulated. […] It is hypothesized that sclerosing mesenteritis results in genetically predisposed individuals who have abnormal responses to healing and repair of connective tissue in response to trauma. […] In a systematic review of the published literature, previous abdominal surgery or abdominal trauma was described in almost 30 percent of patients. […] Sclerosing mesenteritis has been reported in association with both acute abdominal injury and chronic repetitive trauma (eg, pneumatic jackhammer) and inflammation (eg, occult ileal perforation). […] The use of powdered surgical gloves has also been implicated in the development of abdominal fibrosis as a precursor to sclerosing mesenteritis.

• #13 Sclerosing mesenteritis – UpToDate

  https://www.uptodate.com/contents/sclerosing-mesenteritis/print

  Sclerosing mesenteritis is a rare, non-neoplastic inflammatory and fibrotic disease that affects the mesentery. […] The pathogenesis of sclerosing mesenteritis remain unclear, although several mechanisms have been postulated. […] It is hypothesized that sclerosing mesenteritis results in genetically predisposed individuals who have abnormal responses to healing and repair of connective tissue in response to trauma. […] In a systematic review of the published literature, previous abdominal surgery or abdominal trauma was described in almost 30 percent of patients. […] Sclerosing mesenteritis has been reported in association with both acute abdominal injury and chronic repetitive trauma (eg, pneumatic jackhammer) and inflammation (eg, occult ileal perforation). […] The use of powdered surgical gloves has also been implicated in the development of abdominal fibrosis as a precursor to sclerosing mesenteritis.

• #14 Sclerosing Mesenteritis Presenting with Small Bowel Obstruction in a Patient with Compensated Cirrhosis: A Case Report

  https://www.fortunejournals.com/articles/sclerosing-mesenteritis-presenting-with-small-bowel-obstruction-in-a-patient-with-compensated-cirrhosis-a-case-report.html

  Sclerosing Mesenteritis (SM) is a rare fibroinflammatory disease of unknown etiology in which intestinal obstruction results from encasement of variable lengths of bowel by a dense fibrocollagenous membrane that gives the appearance of a cocoon. […] Depending on the etiopathogenesis and the pathological characteristics of the encasing membrane, SM can be classified as primary (idiopathic), secondary or congenital. […] Peritoneal dialysis (PD) is the most common cause of secondary SM. […] Other causes include prior abdominal surgery, beta-blocker treatment, peritoneovenous shunting (PVS) and decompensated cirrhosis complicated by spontaneous bacterial peritonitis (SBP). […] To our knowledge no cases of SM have been reported in patients with compensated cirrhosis without ascites. […] In secondary SM, a local or systemic factor triggers the inflammatory process in the peritoneum.

• #15 Sclerosing mesenteritis: a comprehensive clinical review

  https://atm.amegroups.org/article/view/20473/html

  Sclerosing mesenteritis is a rare disease entity initially described in 1924 with a prevalence reported to be less than 1%. […] The etiology of sclerosing mesenteritis is uncertain, but the disease has been associated with trauma, autoimmune disease, surgery, and malignancy. […] At least four different pathologic processes have been proposed as etiologies of development of sclerosing mesenteritis including abdominal surgery/trauma, autoimmune phenomenon, paraneoplastic process, and ischemia/infection. […] Abdominal surgery has frequently been shown to be a precursor to the development of sclerosing mesenteritis. […] Role of autoimmunity as an etiology of sclerosing mesenteritis has been purported by several authors. […] One of the single biggest debate pertaining to sclerosing mesenteritis has been the question of whether sclerosing mesenteritis is a paraneoplastic syndrome. […] Although infection has been proposed as one of the mechanisms of sclerosing mesenteritis development, there has been very little evidence provided in the published case series or large retrospective chart reviews.

• #16 Sclerosing Mesenteritis: Definition, Types & Treatment

  https://my.clevelandclinic.org/health/diseases/15284-sclerosing-mesenteritis

  Sclerosing mesenteritis is a chronic inflammatory condition that affects your mesentery, which is part of your peritoneum. The inflammation in this condition is idiopathic. It may be a type of autoimmune response. […] The exact cause is unknown, but healthcare providers suspect that its a type of autoimmune disease. That means the inflammation is an inappropriate or overreactive immune response. […] Many people affected have a family history of autoimmune diseases. Research also suggests that as many as 60% of cases may be linked to prior or current cancer, especially lymphoma. […] Research suggests that people whove experienced inflammation from one of these causes are more likely to develop sclerosing mesenteritis. Its as if their mesentery catches the inflammation and continues to keep it alive.

• #17 Sclerosing Mesenteritis: Definition, Types & Treatment

  https://my.clevelandclinic.org/health/diseases/15284-sclerosing-mesenteritis

  Sclerosing mesenteritis is a chronic inflammatory condition that affects your mesentery, which is part of your peritoneum. The inflammation in this condition is idiopathic. It may be a type of autoimmune response. […] The exact cause is unknown, but healthcare providers suspect that its a type of autoimmune disease. That means the inflammation is an inappropriate or overreactive immune response. […] Many people affected have a family history of autoimmune diseases. Research also suggests that as many as 60% of cases may be linked to prior or current cancer, especially lymphoma. […] Research suggests that people whove experienced inflammation from one of these causes are more likely to develop sclerosing mesenteritis. Its as if their mesentery catches the inflammation and continues to keep it alive.

• #18 Mesenteric Panniculitis: Causes, Treatment, and More

  https://www.healthline.com/health/mesenteric-panniculitis

  Mesenteric panniculitis, also known as sclerosing mesenteritis, is a rare disease that causes chronic inflammation. […] It may occur due to infection, surgery, certain medications, injury, or certain types of cancer. […] The specific cause of mesenteric panniculitis isn’t known, but may be related to autoimmune disease, abdominal surgery, injury to your abdomen, bacterial infection, or vascular problems. […] Although the exact cause isn’t known, doctors think mesenteric panniculitis is possibly a type of autoimmune disease. […] In an autoimmune disease, your immune system mistakenly attacks your body’s own tissues. In this case, it attacks the mesentery. […] Inflammation may be triggered by damage to the abdomen, which can be caused by: infection, surgery, some medicines, injuries. […] Cancer can also cause the mesentery to become inflamed and thickened. […] Mesenteric panniculitis has also been linked to cancers, like lymphoma, prostate cancer, and kidney cancer.

• #19 Sclerosing mesenteritis:an uncommon cause of chronic abdominal pain – MedCrave online

  https://medcraveonline.com/GHOA/sclerosing-mesenteritisan-uncommon-cause-of-chronic-abdominal-pain.html

  Furthermore; studies have shown association of SM with conditions like sclerosing cholangitis, Riedel thyroiditis, mixed connective tissue disease, ankylosing spondylitis, Sjogrens syndrome tuberculosis, acute pancreatitis and granulomatous diseases. […] Due to the rarity of the condition, there are no specific guidelines for treatment of SM however steroids, colchicine, azathioprine, thalidomide, cyclophosphamide and progesterone have been tried, however asymptomatic cases don’t need therapy. […] The overall all-cause mortality rate was 7.3% and the common causes of death were postoperative complications, bowel ischemia, sepsis and bronchopneumonia, venous thromboembolism, renal failure, cardiac arrest and pulmonary edema. […] Though most of the cases are benign like ours, they can be associated with underlying malignancy which need to be ruled out.

• #20 Mesenteric panniculitis: Definition, causes, and symptoms

  https://www.medicalnewstoday.com/articles/320596

  Mesenteric panniculitis or sclerosing mesenteritis is a rare disorder that affects the abdomen. The exact cause of it is unknown, but the disorder is associated with certain risk factors and conditions. […] There is currently no known direct cause for mesenteric panniculitis. It is typically treated as an autoimmune disease. […] In mesenteric panniculitis, the body starts attacking the mesentery, causing inflammation, scar tissue, and other symptoms. […] There may be a genetic link to mesenteric panniculitis. […] Additionally, inflammation of the abdomen that may be classified as mesenteric panniculitis can be triggered by other incidents or damage to the abdomen and mesentery, such as from infections, accidents, or surgeries. […] Some types of cancer can also cause inflammation and scarring in the mesentery, including: prostate cancer, kidney cancer, lymphoma, colon cancer, melanoma, stomach cancer, lung cancer, carcinoid tumors. […] Other disorders may also be linked to mesenteric panniculitis. These include some that cause or influence inflammation and scar tissue in the body, such as retroperitoneal fibrosis, sclerosing cholangitis, riedel thyroiditis, orbital pseudotumors.

• #21 Mesenteric panniculitis: Definition, causes, and symptoms

  https://www.medicalnewstoday.com/articles/320596

  Mesenteric panniculitis or sclerosing mesenteritis is a rare disorder that affects the abdomen. The exact cause of it is unknown, but the disorder is associated with certain risk factors and conditions. […] There is currently no known direct cause for mesenteric panniculitis. It is typically treated as an autoimmune disease. […] In mesenteric panniculitis, the body starts attacking the mesentery, causing inflammation, scar tissue, and other symptoms. […] There may be a genetic link to mesenteric panniculitis. […] Additionally, inflammation of the abdomen that may be classified as mesenteric panniculitis can be triggered by other incidents or damage to the abdomen and mesentery, such as from infections, accidents, or surgeries. […] Some types of cancer can also cause inflammation and scarring in the mesentery, including: prostate cancer, kidney cancer, lymphoma, colon cancer, melanoma, stomach cancer, lung cancer, carcinoid tumors. […] Other disorders may also be linked to mesenteric panniculitis. These include some that cause or influence inflammation and scar tissue in the body, such as retroperitoneal fibrosis, sclerosing cholangitis, riedel thyroiditis, orbital pseudotumors.

• #22 Mesenteric panniculitis: Definition, causes, and symptoms

  https://www.medicalnewstoday.com/articles/320596

  Mesenteric panniculitis or sclerosing mesenteritis is a rare disorder that affects the abdomen. The exact cause of it is unknown, but the disorder is associated with certain risk factors and conditions. […] There is currently no known direct cause for mesenteric panniculitis. It is typically treated as an autoimmune disease. […] In mesenteric panniculitis, the body starts attacking the mesentery, causing inflammation, scar tissue, and other symptoms. […] There may be a genetic link to mesenteric panniculitis. […] Additionally, inflammation of the abdomen that may be classified as mesenteric panniculitis can be triggered by other incidents or damage to the abdomen and mesentery, such as from infections, accidents, or surgeries. […] Some types of cancer can also cause inflammation and scarring in the mesentery, including: prostate cancer, kidney cancer, lymphoma, colon cancer, melanoma, stomach cancer, lung cancer, carcinoid tumors. […] Other disorders may also be linked to mesenteric panniculitis. These include some that cause or influence inflammation and scar tissue in the body, such as retroperitoneal fibrosis, sclerosing cholangitis, riedel thyroiditis, orbital pseudotumors.

• #23 Mesenteric panniculitis: Definition, causes, and symptoms

  https://www.medicalnewstoday.com/articles/320596

  Mesenteric panniculitis or sclerosing mesenteritis is a rare disorder that affects the abdomen. The exact cause of it is unknown, but the disorder is associated with certain risk factors and conditions. […] There is currently no known direct cause for mesenteric panniculitis. It is typically treated as an autoimmune disease. […] In mesenteric panniculitis, the body starts attacking the mesentery, causing inflammation, scar tissue, and other symptoms. […] There may be a genetic link to mesenteric panniculitis. […] Additionally, inflammation of the abdomen that may be classified as mesenteric panniculitis can be triggered by other incidents or damage to the abdomen and mesentery, such as from infections, accidents, or surgeries. […] Some types of cancer can also cause inflammation and scarring in the mesentery, including: prostate cancer, kidney cancer, lymphoma, colon cancer, melanoma, stomach cancer, lung cancer, carcinoid tumors. […] Other disorders may also be linked to mesenteric panniculitis. These include some that cause or influence inflammation and scar tissue in the body, such as retroperitoneal fibrosis, sclerosing cholangitis, riedel thyroiditis, orbital pseudotumors.

• #24 Sclerosing mesenteritis:an uncommon cause of chronic abdominal pain – MedCrave online

  https://medcraveonline.com/GHOA/sclerosing-mesenteritisan-uncommon-cause-of-chronic-abdominal-pain.html

  Furthermore; studies have shown association of SM with conditions like sclerosing cholangitis, Riedel thyroiditis, mixed connective tissue disease, ankylosing spondylitis, Sjogrens syndrome tuberculosis, acute pancreatitis and granulomatous diseases. […] Due to the rarity of the condition, there are no specific guidelines for treatment of SM however steroids, colchicine, azathioprine, thalidomide, cyclophosphamide and progesterone have been tried, however asymptomatic cases don’t need therapy. […] The overall all-cause mortality rate was 7.3% and the common causes of death were postoperative complications, bowel ischemia, sepsis and bronchopneumonia, venous thromboembolism, renal failure, cardiac arrest and pulmonary edema. […] Though most of the cases are benign like ours, they can be associated with underlying malignancy which need to be ruled out.

• #25 Sclerosing mesenteritis:an uncommon cause of chronic abdominal pain – MedCrave online

  https://medcraveonline.com/GHOA/sclerosing-mesenteritisan-uncommon-cause-of-chronic-abdominal-pain.html

  Furthermore; studies have shown association of SM with conditions like sclerosing cholangitis, Riedel thyroiditis, mixed connective tissue disease, ankylosing spondylitis, Sjogrens syndrome tuberculosis, acute pancreatitis and granulomatous diseases. […] Due to the rarity of the condition, there are no specific guidelines for treatment of SM however steroids, colchicine, azathioprine, thalidomide, cyclophosphamide and progesterone have been tried, however asymptomatic cases don’t need therapy. […] The overall all-cause mortality rate was 7.3% and the common causes of death were postoperative complications, bowel ischemia, sepsis and bronchopneumonia, venous thromboembolism, renal failure, cardiac arrest and pulmonary edema. […] Though most of the cases are benign like ours, they can be associated with underlying malignancy which need to be ruled out.

• #26 Sclerosing mesenteritis:an uncommon cause of chronic abdominal pain – MedCrave online

  https://medcraveonline.com/GHOA/sclerosing-mesenteritisan-uncommon-cause-of-chronic-abdominal-pain.html

  Furthermore; studies have shown association of SM with conditions like sclerosing cholangitis, Riedel thyroiditis, mixed connective tissue disease, ankylosing spondylitis, Sjogrens syndrome tuberculosis, acute pancreatitis and granulomatous diseases. […] Due to the rarity of the condition, there are no specific guidelines for treatment of SM however steroids, colchicine, azathioprine, thalidomide, cyclophosphamide and progesterone have been tried, however asymptomatic cases don’t need therapy. […] The overall all-cause mortality rate was 7.3% and the common causes of death were postoperative complications, bowel ischemia, sepsis and bronchopneumonia, venous thromboembolism, renal failure, cardiac arrest and pulmonary edema. […] Though most of the cases are benign like ours, they can be associated with underlying malignancy which need to be ruled out.

• #27 IgG4-related sclerosing mesenteritis causing bowel obstruction: a case report | Surgical Case Reports | Full Text

  https://surgicalcasereports.springeropen.com/articles/10.1186/s40792-016-0248-0

  Sclerosing mesenteritis (SM) is a rare inflammatory and fibrosing disease primarily involving the small-bowel mesentery. […] The etiology of SM remains undetermined. Suggested causes include trauma (including surgery), powder on surgical gloves, infection (such as tuberculosis), autoimmune diseases, vascular insufficiency, and retained suture material. […] About 40 to 70 % of patients with SM were found to have undergone previous surgery. […] The pathogenic mechanism of SM seems to be a non-specific response to a wide variety of stimuli. […] SM may be an IgG4-RD, diseases that dramatically respond to corticosteroid treatment. […] Although the incidence of SM related to IgG4-RD has not been determined, SM was observed in 2 (4 %) of 57 patients with autoimmune pancreatitis and marked infiltration of IgG4-positive plasma cells was observed in 4 (33 %) of 12 patients with SM.

• #28 IgG4-related sclerosing mesenteritis causing bowel obstruction: a case report | Surgical Case Reports | Full Text

  https://surgicalcasereports.springeropen.com/articles/10.1186/s40792-016-0248-0

  Sclerosing mesenteritis (SM) is a rare inflammatory and fibrosing disease primarily involving the small-bowel mesentery. […] The etiology of SM remains undetermined. Suggested causes include trauma (including surgery), powder on surgical gloves, infection (such as tuberculosis), autoimmune diseases, vascular insufficiency, and retained suture material. […] About 40 to 70 % of patients with SM were found to have undergone previous surgery. […] The pathogenic mechanism of SM seems to be a non-specific response to a wide variety of stimuli. […] SM may be an IgG4-RD, diseases that dramatically respond to corticosteroid treatment. […] Although the incidence of SM related to IgG4-RD has not been determined, SM was observed in 2 (4 %) of 57 patients with autoimmune pancreatitis and marked infiltration of IgG4-positive plasma cells was observed in 4 (33 %) of 12 patients with SM.

• #29 IgG4-Related Sclerosing Mesenteritis

  https://www.jpatholtm.org/journal/view.php?doi=10.4132/jptm.2015.12.03

  Sclerosing mesenteritis (SM) is a rare disease first described by Sulla in 1924 under the name retractile mesenteritis. SM shows fibrosis with fat necrosis and chronic inflammation on microscopic examination. […] In particular, if the histologic and immunologic features are associated with IgG4-related disease (IgG4-RD), the condition is defined as IgG4-related sclerosing mesenteritis (IgG4-RSM). […] IgG4-RSM is known as a rare mesenteric disease of unknown etiology, although prior abdominal surgery can result in SM. […] The age of patients with IgG4-RSM ranges from 48 to 82. […] There is no generalized consensus regarding the treatment of SM, including medical therapy, surgical therapy, and surgery with additional medical therapy. […] IgG4-RSM has a male predominance similar to SM.

• #30 Sclerosing mesenteritis: a comprehensive clinical review

  https://atm.amegroups.org/article/view/20473/html

  Sclerosing mesenteritis is a rare disease entity initially described in 1924 with a prevalence reported to be less than 1%. […] The etiology of sclerosing mesenteritis is uncertain, but the disease has been associated with trauma, autoimmune disease, surgery, and malignancy. […] At least four different pathologic processes have been proposed as etiologies of development of sclerosing mesenteritis including abdominal surgery/trauma, autoimmune phenomenon, paraneoplastic process, and ischemia/infection. […] Abdominal surgery has frequently been shown to be a precursor to the development of sclerosing mesenteritis. […] Role of autoimmunity as an etiology of sclerosing mesenteritis has been purported by several authors. […] One of the single biggest debate pertaining to sclerosing mesenteritis has been the question of whether sclerosing mesenteritis is a paraneoplastic syndrome. […] Although infection has been proposed as one of the mechanisms of sclerosing mesenteritis development, there has been very little evidence provided in the published case series or large retrospective chart reviews.

• #31 Sclerosing Mesenteritis: Definition, Types & Treatment

  https://my.clevelandclinic.org/health/diseases/15284-sclerosing-mesenteritis

  Sclerosing mesenteritis is a chronic inflammatory condition that affects your mesentery, which is part of your peritoneum. The inflammation in this condition is idiopathic. It may be a type of autoimmune response. […] The exact cause is unknown, but healthcare providers suspect that its a type of autoimmune disease. That means the inflammation is an inappropriate or overreactive immune response. […] Many people affected have a family history of autoimmune diseases. Research also suggests that as many as 60% of cases may be linked to prior or current cancer, especially lymphoma. […] Research suggests that people whove experienced inflammation from one of these causes are more likely to develop sclerosing mesenteritis. Its as if their mesentery catches the inflammation and continues to keep it alive.

• #32 Mesenteric panniculitis: Definition, causes, and symptoms

  https://www.medicalnewstoday.com/articles/320596

  Mesenteric panniculitis or sclerosing mesenteritis is a rare disorder that affects the abdomen. The exact cause of it is unknown, but the disorder is associated with certain risk factors and conditions. […] There is currently no known direct cause for mesenteric panniculitis. It is typically treated as an autoimmune disease. […] In mesenteric panniculitis, the body starts attacking the mesentery, causing inflammation, scar tissue, and other symptoms. […] There may be a genetic link to mesenteric panniculitis. […] Additionally, inflammation of the abdomen that may be classified as mesenteric panniculitis can be triggered by other incidents or damage to the abdomen and mesentery, such as from infections, accidents, or surgeries. […] Some types of cancer can also cause inflammation and scarring in the mesentery, including: prostate cancer, kidney cancer, lymphoma, colon cancer, melanoma, stomach cancer, lung cancer, carcinoid tumors. […] Other disorders may also be linked to mesenteric panniculitis. These include some that cause or influence inflammation and scar tissue in the body, such as retroperitoneal fibrosis, sclerosing cholangitis, riedel thyroiditis, orbital pseudotumors.

• #33 Sclerosing Mesenteritis: A Rare Cause of Abdominal Pain

  https://pmc.ncbi.nlm.nih.gov/articles/PMC9520956/

  Sclerosing mesenteritis (SM) is a rare inflammatory fibrotic disease of the small intestine mesenteric fat often discovered incidentally on a CT scan. […] SM is more common in men than women with a ratio of 2:1. It mostly occurs during the fifth to seventh decades of life, with a patients median age of 65 years. […] Besides cancer, SM is associated with other conditions that have been suggested as possible causes, such as previous abdominal surgery or trauma, autoimmune disease, abdominal aortic aneurysm, and infection, but at this time the etiology is unknown. […] There are some reports of SM being a paraneoplastic syndrome but there is conflicting data. […] The most common cancers in this series were lymphoma, melanoma, colon, and prostate two of which were present in our patient. […] A CT scan case-control study by van Putte-Katier et al. showed a significant increase in cancer with lymphoma being the third highest in prevalence. […] A heightened awareness of this disease may prompt further evaluation, especially in patients with more severe or uncontrolled symptoms.

• #34 Sclerosing Mesenteritis: A Rare Cause of Abdominal Pain

  https://pmc.ncbi.nlm.nih.gov/articles/PMC9520956/

  Sclerosing mesenteritis (SM) is a rare inflammatory fibrotic disease of the small intestine mesenteric fat often discovered incidentally on a CT scan. […] SM is more common in men than women with a ratio of 2:1. It mostly occurs during the fifth to seventh decades of life, with a patients median age of 65 years. […] Besides cancer, SM is associated with other conditions that have been suggested as possible causes, such as previous abdominal surgery or trauma, autoimmune disease, abdominal aortic aneurysm, and infection, but at this time the etiology is unknown. […] There are some reports of SM being a paraneoplastic syndrome but there is conflicting data. […] The most common cancers in this series were lymphoma, melanoma, colon, and prostate two of which were present in our patient. […] A CT scan case-control study by van Putte-Katier et al. showed a significant increase in cancer with lymphoma being the third highest in prevalence. […] A heightened awareness of this disease may prompt further evaluation, especially in patients with more severe or uncontrolled symptoms.

• #35 Frontiers | Sclerosing Mesenteritis, a Rare Cause of Mesenteric Mass in a Young Adult: A Case Report

  https://www.frontiersin.org/journals/surgery/articles/10.3389/fsurg.2021.722312/full

  The onset of SM is often associated with autoimmune conditions, such as IgG4 mediated sclerosing disorders, Lupus, rheumatoid arthritis, Riedel thyroiditis, and primary sclerosing cholangitis. […] In our case no predisposing factor was noted nor were there history of previous surgery, trauma, autoimmune disease, infection, or neoplasms. […] The association between SM and malignancies still remains a matter of debate; in favor of the association are the studies of Ogden et al. and of Jura, which demonstrated an association with lymphoma in 8 out of 53 and 2 out of 7 patients, respectively. […] The main differential diagnoses of SM revolve around GIST (gastrointestinal stromal tumor) and mesenteric fibromatosis.

• #36 Sclerosing Mesenteritis: A Rare Cause of Abdominal Pain

  https://pmc.ncbi.nlm.nih.gov/articles/PMC9520956/

  Sclerosing mesenteritis (SM) is a rare inflammatory fibrotic disease of the small intestine mesenteric fat often discovered incidentally on a CT scan. […] SM is more common in men than women with a ratio of 2:1. It mostly occurs during the fifth to seventh decades of life, with a patients median age of 65 years. […] Besides cancer, SM is associated with other conditions that have been suggested as possible causes, such as previous abdominal surgery or trauma, autoimmune disease, abdominal aortic aneurysm, and infection, but at this time the etiology is unknown. […] There are some reports of SM being a paraneoplastic syndrome but there is conflicting data. […] The most common cancers in this series were lymphoma, melanoma, colon, and prostate two of which were present in our patient. […] A CT scan case-control study by van Putte-Katier et al. showed a significant increase in cancer with lymphoma being the third highest in prevalence. […] A heightened awareness of this disease may prompt further evaluation, especially in patients with more severe or uncontrolled symptoms.

• #37 Sclerosing Mesenteritis: A Rare Cause of Abdominal Pain

  https://pmc.ncbi.nlm.nih.gov/articles/PMC9520956/

  Sclerosing mesenteritis (SM) is a rare inflammatory fibrotic disease of the small intestine mesenteric fat often discovered incidentally on a CT scan. […] SM is more common in men than women with a ratio of 2:1. It mostly occurs during the fifth to seventh decades of life, with a patients median age of 65 years. […] Besides cancer, SM is associated with other conditions that have been suggested as possible causes, such as previous abdominal surgery or trauma, autoimmune disease, abdominal aortic aneurysm, and infection, but at this time the etiology is unknown. […] There are some reports of SM being a paraneoplastic syndrome but there is conflicting data. […] The most common cancers in this series were lymphoma, melanoma, colon, and prostate two of which were present in our patient. […] A CT scan case-control study by van Putte-Katier et al. showed a significant increase in cancer with lymphoma being the third highest in prevalence. […] A heightened awareness of this disease may prompt further evaluation, especially in patients with more severe or uncontrolled symptoms.

• #38 Sclerosing Mesenteritis: A Rare Cause of Abdominal Pain

  https://pmc.ncbi.nlm.nih.gov/articles/PMC9520956/

  Sclerosing mesenteritis (SM) is a rare inflammatory fibrotic disease of the small intestine mesenteric fat often discovered incidentally on a CT scan. […] SM is more common in men than women with a ratio of 2:1. It mostly occurs during the fifth to seventh decades of life, with a patients median age of 65 years. […] Besides cancer, SM is associated with other conditions that have been suggested as possible causes, such as previous abdominal surgery or trauma, autoimmune disease, abdominal aortic aneurysm, and infection, but at this time the etiology is unknown. […] There are some reports of SM being a paraneoplastic syndrome but there is conflicting data. […] The most common cancers in this series were lymphoma, melanoma, colon, and prostate two of which were present in our patient. […] A CT scan case-control study by van Putte-Katier et al. showed a significant increase in cancer with lymphoma being the third highest in prevalence. […] A heightened awareness of this disease may prompt further evaluation, especially in patients with more severe or uncontrolled symptoms.

• #39 Ultrasonography-based Management of Sclerosing Mesenteritis | IMCRJ

  https://www.dovepress.com/ultrasonography-based-management-of-sclerosing-mesenteritis-from-diagn-peer-reviewed-fulltext-article-IMCRJ

  Sclerosing mesenteritis (SM) is an idiopathic disorder affecting mesentery, characterized by fat necrosis, chronic inflammation and fibrosis. […] Although the etiopathogenesis is still unclear, previous abdominal trauma or surgery, cancer, autoimmunity, infection, and medications have been linked to the development of SM. […] The most common conditions associated with SM are previous abdominal trauma or surgery; in this context, SM might be the result of an abnormal response to healing and repair of connective tissue after trauma or surgery in genetically predisposed subjects. […] Moreover, SM has also been considered a paraneoplastic syndrome, since it is associated with different malignancies, such as lymphomas, chronic lymphocytic leukemia, myeloma, carcinoid, gastrointestinal cancers, renal cancer, and lung cancer. […] SM has been hypothesized to be a progressive inflammatory process, moving from mesenteric lipodystrophy to retractile mesenteritis, triggered by a wide variety of stimuli.

• #40 Ultrasonography-based Management of Sclerosing Mesenteritis | IMCRJ

  https://www.dovepress.com/ultrasonography-based-management-of-sclerosing-mesenteritis-from-diagn-peer-reviewed-fulltext-article-IMCRJ

  Sclerosing mesenteritis (SM) is an idiopathic disorder affecting mesentery, characterized by fat necrosis, chronic inflammation and fibrosis. […] Although the etiopathogenesis is still unclear, previous abdominal trauma or surgery, cancer, autoimmunity, infection, and medications have been linked to the development of SM. […] The most common conditions associated with SM are previous abdominal trauma or surgery; in this context, SM might be the result of an abnormal response to healing and repair of connective tissue after trauma or surgery in genetically predisposed subjects. […] Moreover, SM has also been considered a paraneoplastic syndrome, since it is associated with different malignancies, such as lymphomas, chronic lymphocytic leukemia, myeloma, carcinoid, gastrointestinal cancers, renal cancer, and lung cancer. […] SM has been hypothesized to be a progressive inflammatory process, moving from mesenteric lipodystrophy to retractile mesenteritis, triggered by a wide variety of stimuli.

• #41 Ultrasonography-based Management of Sclerosing Mesenteritis | IMCRJ

  https://www.dovepress.com/ultrasonography-based-management-of-sclerosing-mesenteritis-from-diagn-peer-reviewed-fulltext-article-IMCRJ

  Sclerosing mesenteritis (SM) is an idiopathic disorder affecting mesentery, characterized by fat necrosis, chronic inflammation and fibrosis. […] Although the etiopathogenesis is still unclear, previous abdominal trauma or surgery, cancer, autoimmunity, infection, and medications have been linked to the development of SM. […] The most common conditions associated with SM are previous abdominal trauma or surgery; in this context, SM might be the result of an abnormal response to healing and repair of connective tissue after trauma or surgery in genetically predisposed subjects. […] Moreover, SM has also been considered a paraneoplastic syndrome, since it is associated with different malignancies, such as lymphomas, chronic lymphocytic leukemia, myeloma, carcinoid, gastrointestinal cancers, renal cancer, and lung cancer. […] SM has been hypothesized to be a progressive inflammatory process, moving from mesenteric lipodystrophy to retractile mesenteritis, triggered by a wide variety of stimuli.

• #42 Ultrasonography-based Management of Sclerosing Mesenteritis | IMCRJ

  https://www.dovepress.com/ultrasonography-based-management-of-sclerosing-mesenteritis-from-diagn-peer-reviewed-fulltext-article-IMCRJ

  Sclerosing mesenteritis (SM) is an idiopathic disorder affecting mesentery, characterized by fat necrosis, chronic inflammation and fibrosis. […] Although the etiopathogenesis is still unclear, previous abdominal trauma or surgery, cancer, autoimmunity, infection, and medications have been linked to the development of SM. […] The most common conditions associated with SM are previous abdominal trauma or surgery; in this context, SM might be the result of an abnormal response to healing and repair of connective tissue after trauma or surgery in genetically predisposed subjects. […] Moreover, SM has also been considered a paraneoplastic syndrome, since it is associated with different malignancies, such as lymphomas, chronic lymphocytic leukemia, myeloma, carcinoid, gastrointestinal cancers, renal cancer, and lung cancer. […] SM has been hypothesized to be a progressive inflammatory process, moving from mesenteric lipodystrophy to retractile mesenteritis, triggered by a wide variety of stimuli.

• #43 Ultrasonography-based Management of Sclerosing Mesenteritis | IMCRJ

  https://www.dovepress.com/ultrasonography-based-management-of-sclerosing-mesenteritis-from-diagn-peer-reviewed-fulltext-article-IMCRJ

  Sclerosing mesenteritis (SM) is an idiopathic disorder affecting mesentery, characterized by fat necrosis, chronic inflammation and fibrosis. […] Although the etiopathogenesis is still unclear, previous abdominal trauma or surgery, cancer, autoimmunity, infection, and medications have been linked to the development of SM. […] The most common conditions associated with SM are previous abdominal trauma or surgery; in this context, SM might be the result of an abnormal response to healing and repair of connective tissue after trauma or surgery in genetically predisposed subjects. […] Moreover, SM has also been considered a paraneoplastic syndrome, since it is associated with different malignancies, such as lymphomas, chronic lymphocytic leukemia, myeloma, carcinoid, gastrointestinal cancers, renal cancer, and lung cancer. […] SM has been hypothesized to be a progressive inflammatory process, moving from mesenteric lipodystrophy to retractile mesenteritis, triggered by a wide variety of stimuli.

• #44 Sclerosing Mesenteritis: A Rare Cause of Abdominal Pain

  https://pmc.ncbi.nlm.nih.gov/articles/PMC9520956/

  Sclerosing mesenteritis (SM) is a rare inflammatory fibrotic disease of the small intestine mesenteric fat often discovered incidentally on a CT scan. […] SM is more common in men than women with a ratio of 2:1. It mostly occurs during the fifth to seventh decades of life, with a patients median age of 65 years. […] Besides cancer, SM is associated with other conditions that have been suggested as possible causes, such as previous abdominal surgery or trauma, autoimmune disease, abdominal aortic aneurysm, and infection, but at this time the etiology is unknown. […] There are some reports of SM being a paraneoplastic syndrome but there is conflicting data. […] The most common cancers in this series were lymphoma, melanoma, colon, and prostate two of which were present in our patient. […] A CT scan case-control study by van Putte-Katier et al. showed a significant increase in cancer with lymphoma being the third highest in prevalence. […] A heightened awareness of this disease may prompt further evaluation, especially in patients with more severe or uncontrolled symptoms.

• #45 Sclerosing mesenteritis | Radiology Reference Article | Radiopaedia.org

  https://radiopaedia.org/articles/sclerosing-mesenteritis-1?embed_domain=hackmd.io%25252F%252540yIPUAFeCSL2JsU8smR5nJQ%25252Fbnjhjgjghjghjghfavicon.ico&lang=us

  Sclerosing mesenteritis, also known as mesenteric panniculitis or retractile mesenteritis, is an uncommon idiopathic disorder characterized by chronic non-specific inflammation involving the adipose tissue of the bowel mesentery. […] There is debate about the association between systemic inflammatory conditions and mesenteric panniculitis. Determining causation is difficult. The term „secondary mesenteric panniculitis” is reserved by some authors for patients with systemic inflammatory conditions. Most authors would not use the term when there is a local cause for mesenteric inflammation. […] While local lymphoma (in up to 15% of cases) and a more general association with malignancy of 37-56% have been suggested, a true association has not been proved. In patients diagnosed with mesenteric panniculitis, lymphadenopathy 12 mm, and absence of a 'fat halo’ around lymph nodes and vessels increased the risk of subsequent malignancy diagnosis in one study. Limitations of studies suggesting a malignancy association have been highlighted, and contrary evidence including a systematic review and meta-analysis, and case matched cohort studies have dismissed such an association.

• #46 Sclerosing mesenteritis | Radiology Reference Article | Radiopaedia.org

  https://radiopaedia.org/articles/sclerosing-mesenteritis-1?embed_domain=hackmd.io%25252F%252540yIPUAFeCSL2JsU8smR5nJQ%25252Fbnjhjgjghjghjghfavicon.ico&lang=us

  Sclerosing mesenteritis, also known as mesenteric panniculitis or retractile mesenteritis, is an uncommon idiopathic disorder characterized by chronic non-specific inflammation involving the adipose tissue of the bowel mesentery. […] There is debate about the association between systemic inflammatory conditions and mesenteric panniculitis. Determining causation is difficult. The term „secondary mesenteric panniculitis” is reserved by some authors for patients with systemic inflammatory conditions. Most authors would not use the term when there is a local cause for mesenteric inflammation. […] While local lymphoma (in up to 15% of cases) and a more general association with malignancy of 37-56% have been suggested, a true association has not been proved. In patients diagnosed with mesenteric panniculitis, lymphadenopathy 12 mm, and absence of a 'fat halo’ around lymph nodes and vessels increased the risk of subsequent malignancy diagnosis in one study. Limitations of studies suggesting a malignancy association have been highlighted, and contrary evidence including a systematic review and meta-analysis, and case matched cohort studies have dismissed such an association.

• #47 Sclerosing mesenteritis | Radiology Reference Article | Radiopaedia.org

  https://radiopaedia.org/articles/sclerosing-mesenteritis-1?embed_domain=hackmd.io%25252F%252540yIPUAFeCSL2JsU8smR5nJQ%25252Fbnjhjgjghjghjghfavicon.ico&lang=us

  Sclerosing mesenteritis, also known as mesenteric panniculitis or retractile mesenteritis, is an uncommon idiopathic disorder characterized by chronic non-specific inflammation involving the adipose tissue of the bowel mesentery. […] There is debate about the association between systemic inflammatory conditions and mesenteric panniculitis. Determining causation is difficult. The term „secondary mesenteric panniculitis” is reserved by some authors for patients with systemic inflammatory conditions. Most authors would not use the term when there is a local cause for mesenteric inflammation. […] While local lymphoma (in up to 15% of cases) and a more general association with malignancy of 37-56% have been suggested, a true association has not been proved. In patients diagnosed with mesenteric panniculitis, lymphadenopathy 12 mm, and absence of a 'fat halo’ around lymph nodes and vessels increased the risk of subsequent malignancy diagnosis in one study. Limitations of studies suggesting a malignancy association have been highlighted, and contrary evidence including a systematic review and meta-analysis, and case matched cohort studies have dismissed such an association.

• #48 Sclerosing mesenteritis: a comprehensive clinical review

  https://atm.amegroups.org/article/view/20473/html

  Sclerosing mesenteritis is a rare disease entity initially described in 1924 with a prevalence reported to be less than 1%. […] The etiology of sclerosing mesenteritis is uncertain, but the disease has been associated with trauma, autoimmune disease, surgery, and malignancy. […] At least four different pathologic processes have been proposed as etiologies of development of sclerosing mesenteritis including abdominal surgery/trauma, autoimmune phenomenon, paraneoplastic process, and ischemia/infection. […] Abdominal surgery has frequently been shown to be a precursor to the development of sclerosing mesenteritis. […] Role of autoimmunity as an etiology of sclerosing mesenteritis has been purported by several authors. […] One of the single biggest debate pertaining to sclerosing mesenteritis has been the question of whether sclerosing mesenteritis is a paraneoplastic syndrome. […] Although infection has been proposed as one of the mechanisms of sclerosing mesenteritis development, there has been very little evidence provided in the published case series or large retrospective chart reviews.

• #49 Sclerosing Mesenteritis : Causes, Symptoms and Treatment

  https://www.apollohospitals.com/diseases-and-conditions/what-are-the-causes-symptoms-and-treatment-for-sclerosing-mesenteritis

  Sclerosing Mesenteritis, also known as mesenteric panniculitis, occurs when mesentery (the tissue) that holds small intestines in place becomes inflamed and forms a scar tissue. […] Sclerosing Mesenteritis is a rare condition, and its not clear what causes it. […] Although the actual cause of Sclerosing mesenteritis remains unclear, several factors and conditions are believed to be associated with Sclerosing Mesenteritis. Some of the possible factors that increase the risk of developing Sclerosing Mesenteritis includes: Abdominal trauma, Gastrointestinal surgery, Autoimmune disorders, Paraneoplastic syndrome- abnormal immune response to cancer cells in the body, Ischemia or reduced blood supply to organs, Infections such as typhoid fever, malaria, Neoplastic disease (tumor).

• #50 Idiopathic sclerosing mesenteritis – Wikipedia

  https://en.wikipedia.org/wiki/Idiopathic_sclerosing_mesenteritis

  Causes Not known […] Several causes of sclerosing mesenteritis have been suggested such as trauma, prior surgical procedures, autoimmune diseases such as lupus, IgG4-related disease, rheumatoid arthritis, infections such as tuberculosis, cryptococcosis, schistosomiasis, HIV and medicines such as paroxetine and pergolide but their associations with sclerosing mesenteritis are largely speculative with high degree of bias.

• #51 Sclerosing Mesenteritis-Update on Diagnostic and Therapeutic Appr

  https://www.itmedicalteam.pl/articles/sclerosing-mesenteritisupdate-on-diagnostic-and-therapeutic-approach-108510.html

  The association with infections proved to be more evident in patients with personal history of infection with typhoid, dysentery, tuberculosis, syphilis, malaria, influenza and rheumatic fever. […] The sclerosing mesenteritis has usually a benign, self-limited course, slowly progressive evolution and resolves spontaneously in most cases, showing a favorable prognosis. This mainly depends on a correct diagnosis and extent of fibrotic process. […] The association with malignancy can be coincidental or secondary to autoimmune inflammatory reaction. However, the exact mechanism has yet to be elucidated.

• #52 Sclerosing Mesenteritis-Update on Diagnostic and Therapeutic Appr

  https://www.itmedicalteam.pl/articles/sclerosing-mesenteritisupdate-on-diagnostic-and-therapeutic-approach-108510.html

  The etiology of SM remains unknown, although several mechanisms have been suggested contributors, including surgery or abdominal trauma before, autoimmunity, paraneoplastic syndrome, ischemic injury and infections. […] The SM has unknown etiology and can occur independently or in association with other disorders. […] Various mechanisms are being suggested based on case reports and animal studies. Among them, include abdominal trauma, previous surgery, autoimmune diseases, ischemic injury, and paraneoplastic syndromes, infections. […] The SM has been described in association with a number of conditions, including autoimmune thyroiditis, presumably of Riedel, primary sclerosing cholangitis, retroperitoneal fibrosis, and orbital pseudotumor. […] The ischemic lesions are described correlated with the previous surgery, abdominal trauma, mesenteric thrombosis and mesenteric arteriopathy.

• #53 Sclerosing Mesenteritis Presenting with Small Bowel Obstruction in a Patient with Compensated Cirrhosis: A Case Report

  https://www.fortunejournals.com/articles/sclerosing-mesenteritis-presenting-with-small-bowel-obstruction-in-a-patient-with-compensated-cirrhosis-a-case-report.html

  PD is the most common cause. […] Other rare causes include prior abdominal surgery, beta-blocker treatment, subclinical primary peritonitis, recurrent peritonitis, chemotherapy (methotrexate), PVS, and more rarely abdominal tuberculosis, sarcoidosis, familial Mediterranean fever, systemic lupus erythematous, intraperitoneal chemotherapy, cirrhosis, liver transplantation, gastrointestinal malignancy, endometriosis, protein S deficiency and fibrogenic foreign material. […] In cirrhotic patients SM has been described after PVS and in those treated with beta-blockers. […] It should also be included in the differential diagnosis in cirrhotic patients with recurrent intraabdominal infection, such as SBP, who present with symptoms of intestinal obstruction. […] However our patient was diagnosed with compensated alcoholic cirrhosis (Child-Pugh A score) and had neither of these conditions.

• #54 Idiopathic sclerosing mesenteritis – Wikipedia

  https://en.wikipedia.org/wiki/Idiopathic_sclerosing_mesenteritis

  Causes Not known […] Several causes of sclerosing mesenteritis have been suggested such as trauma, prior surgical procedures, autoimmune diseases such as lupus, IgG4-related disease, rheumatoid arthritis, infections such as tuberculosis, cryptococcosis, schistosomiasis, HIV and medicines such as paroxetine and pergolide but their associations with sclerosing mesenteritis are largely speculative with high degree of bias.

• #55 Sclerosing mesenteritis:an uncommon cause of chronic abdominal pain – MedCrave online

  https://medcraveonline.com/GHOA/sclerosing-mesenteritisan-uncommon-cause-of-chronic-abdominal-pain.html

  Furthermore; studies have shown association of SM with conditions like sclerosing cholangitis, Riedel thyroiditis, mixed connective tissue disease, ankylosing spondylitis, Sjogrens syndrome tuberculosis, acute pancreatitis and granulomatous diseases. […] Due to the rarity of the condition, there are no specific guidelines for treatment of SM however steroids, colchicine, azathioprine, thalidomide, cyclophosphamide and progesterone have been tried, however asymptomatic cases don’t need therapy. […] The overall all-cause mortality rate was 7.3% and the common causes of death were postoperative complications, bowel ischemia, sepsis and bronchopneumonia, venous thromboembolism, renal failure, cardiac arrest and pulmonary edema. […] Though most of the cases are benign like ours, they can be associated with underlying malignancy which need to be ruled out.

• #56 Sclerosing Mesenteritis: A Rare Cause of Abdominal Pain

  https://pmc.ncbi.nlm.nih.gov/articles/PMC9520956/

  Sclerosing mesenteritis (SM) is a rare inflammatory fibrotic disease of the small intestine mesenteric fat often discovered incidentally on a CT scan. […] SM is more common in men than women with a ratio of 2:1. It mostly occurs during the fifth to seventh decades of life, with a patients median age of 65 years. […] Besides cancer, SM is associated with other conditions that have been suggested as possible causes, such as previous abdominal surgery or trauma, autoimmune disease, abdominal aortic aneurysm, and infection, but at this time the etiology is unknown. […] There are some reports of SM being a paraneoplastic syndrome but there is conflicting data. […] The most common cancers in this series were lymphoma, melanoma, colon, and prostate two of which were present in our patient. […] A CT scan case-control study by van Putte-Katier et al. showed a significant increase in cancer with lymphoma being the third highest in prevalence. […] A heightened awareness of this disease may prompt further evaluation, especially in patients with more severe or uncontrolled symptoms.

• #57 Sclerosing Mesenteritis Presenting with Small Bowel Obstruction in a Patient with Compensated Cirrhosis: A Case Report

  https://www.fortunejournals.com/articles/sclerosing-mesenteritis-presenting-with-small-bowel-obstruction-in-a-patient-with-compensated-cirrhosis-a-case-report.html

  PD is the most common cause. […] Other rare causes include prior abdominal surgery, beta-blocker treatment, subclinical primary peritonitis, recurrent peritonitis, chemotherapy (methotrexate), PVS, and more rarely abdominal tuberculosis, sarcoidosis, familial Mediterranean fever, systemic lupus erythematous, intraperitoneal chemotherapy, cirrhosis, liver transplantation, gastrointestinal malignancy, endometriosis, protein S deficiency and fibrogenic foreign material. […] In cirrhotic patients SM has been described after PVS and in those treated with beta-blockers. […] It should also be included in the differential diagnosis in cirrhotic patients with recurrent intraabdominal infection, such as SBP, who present with symptoms of intestinal obstruction. […] However our patient was diagnosed with compensated alcoholic cirrhosis (Child-Pugh A score) and had neither of these conditions.

• #58 Sclerosing Mesenteritis Presenting with Small Bowel Obstruction in a Patient with Compensated Cirrhosis: A Case Report

  https://www.fortunejournals.com/articles/sclerosing-mesenteritis-presenting-with-small-bowel-obstruction-in-a-patient-with-compensated-cirrhosis-a-case-report.html

  PD is the most common cause. […] Other rare causes include prior abdominal surgery, beta-blocker treatment, subclinical primary peritonitis, recurrent peritonitis, chemotherapy (methotrexate), PVS, and more rarely abdominal tuberculosis, sarcoidosis, familial Mediterranean fever, systemic lupus erythematous, intraperitoneal chemotherapy, cirrhosis, liver transplantation, gastrointestinal malignancy, endometriosis, protein S deficiency and fibrogenic foreign material. […] In cirrhotic patients SM has been described after PVS and in those treated with beta-blockers. […] It should also be included in the differential diagnosis in cirrhotic patients with recurrent intraabdominal infection, such as SBP, who present with symptoms of intestinal obstruction. […] However our patient was diagnosed with compensated alcoholic cirrhosis (Child-Pugh A score) and had neither of these conditions.

• #59 Sclerosing mesenteritis:an uncommon cause of chronic abdominal pain – MedCrave online

  https://medcraveonline.com/GHOA/sclerosing-mesenteritisan-uncommon-cause-of-chronic-abdominal-pain.html

  Furthermore; studies have shown association of SM with conditions like sclerosing cholangitis, Riedel thyroiditis, mixed connective tissue disease, ankylosing spondylitis, Sjogrens syndrome tuberculosis, acute pancreatitis and granulomatous diseases. […] Due to the rarity of the condition, there are no specific guidelines for treatment of SM however steroids, colchicine, azathioprine, thalidomide, cyclophosphamide and progesterone have been tried, however asymptomatic cases don’t need therapy. […] The overall all-cause mortality rate was 7.3% and the common causes of death were postoperative complications, bowel ischemia, sepsis and bronchopneumonia, venous thromboembolism, renal failure, cardiac arrest and pulmonary edema. […] Though most of the cases are benign like ours, they can be associated with underlying malignancy which need to be ruled out.

• #60

  https://journals.lww.com/ajg/fulltext/2017/10001/pancreatitis_associated_sclerosing_mesenteritis__a.1360.aspx

  Sclerosing mesenteritis, first described by Jura in 1924 as retractable mesenteritis, rarely involves the pancreas. […] The etiology of sclerosing mesenteritis remains unclear. […] We hypothesize that our patient’s acute pancreatitis may have precipitated the development of sclerosing mesenteritis. […] Pancreatic involvement in sclerosing mesenteritis is rare.

• #61 Sclerosing Mesenteritis Presenting with Small Bowel Obstruction in a Patient with Compensated Cirrhosis: A Case Report

  https://www.fortunejournals.com/articles/sclerosing-mesenteritis-presenting-with-small-bowel-obstruction-in-a-patient-with-compensated-cirrhosis-a-case-report.html

  PD is the most common cause. […] Other rare causes include prior abdominal surgery, beta-blocker treatment, subclinical primary peritonitis, recurrent peritonitis, chemotherapy (methotrexate), PVS, and more rarely abdominal tuberculosis, sarcoidosis, familial Mediterranean fever, systemic lupus erythematous, intraperitoneal chemotherapy, cirrhosis, liver transplantation, gastrointestinal malignancy, endometriosis, protein S deficiency and fibrogenic foreign material. […] In cirrhotic patients SM has been described after PVS and in those treated with beta-blockers. […] It should also be included in the differential diagnosis in cirrhotic patients with recurrent intraabdominal infection, such as SBP, who present with symptoms of intestinal obstruction. […] However our patient was diagnosed with compensated alcoholic cirrhosis (Child-Pugh A score) and had neither of these conditions.

• #62 Mesenteric Panniculitis: Symptoms, Causes, Treatments, Diet

  https://resources.healthgrades.com/right-care/symptoms-and-conditions/mesenteric-panniculitis

  Mesenteric panniculitis is a rare condition that causes inflammation in the mesenteric tissue, which holds the intestines in place. This condition can cause scar tissue and various symptoms to occur. […] The exact cause of mesenteric panniculitis is unknown. […] However, various factors make it more likely to occur. These include: abdominal surgery, internal bile or urinary leak, bacterial and viral infection, vasculitis, chemical injuries. […] Research suggests that mesenteric panniculitis is an autoimmune disorder due to the inflammation in biopsy samples. Additionally, mesenteric panniculitis symptoms are similar to other autoimmune conditions, such as Crohn’s disease and rheumatoid arthritis. […] Blood tests have shown that inflammatory markers are higher in people with mesenteric panniculitis. There is also a link between those with mesenteric panniculitis and those with a family history of autoimmune diseases. […] People with mesenteric panniculitis may have an underlying form of cancer, too. The types of cancers include: lymphoma, colon, renal, prostate, carcinoid tumor. […] The exact cause of mesenteric panniculitis is not always clear. As such, it may not be possible to prevent the condition.

• #63 Mesenteric Panniculitis: Symptoms, Causes, Treatments, Diet

  https://resources.healthgrades.com/right-care/symptoms-and-conditions/mesenteric-panniculitis

  Mesenteric panniculitis is a rare condition that causes inflammation in the mesenteric tissue, which holds the intestines in place. This condition can cause scar tissue and various symptoms to occur. […] The exact cause of mesenteric panniculitis is unknown. […] However, various factors make it more likely to occur. These include: abdominal surgery, internal bile or urinary leak, bacterial and viral infection, vasculitis, chemical injuries. […] Research suggests that mesenteric panniculitis is an autoimmune disorder due to the inflammation in biopsy samples. Additionally, mesenteric panniculitis symptoms are similar to other autoimmune conditions, such as Crohn’s disease and rheumatoid arthritis. […] Blood tests have shown that inflammatory markers are higher in people with mesenteric panniculitis. There is also a link between those with mesenteric panniculitis and those with a family history of autoimmune diseases. […] People with mesenteric panniculitis may have an underlying form of cancer, too. The types of cancers include: lymphoma, colon, renal, prostate, carcinoid tumor. […] The exact cause of mesenteric panniculitis is not always clear. As such, it may not be possible to prevent the condition.

• #64 Sclerosing Mesenteritis Presenting with Small Bowel Obstruction in a Patient with Compensated Cirrhosis: A Case Report

  https://www.fortunejournals.com/articles/sclerosing-mesenteritis-presenting-with-small-bowel-obstruction-in-a-patient-with-compensated-cirrhosis-a-case-report.html

  PD is the most common cause. […] Other rare causes include prior abdominal surgery, beta-blocker treatment, subclinical primary peritonitis, recurrent peritonitis, chemotherapy (methotrexate), PVS, and more rarely abdominal tuberculosis, sarcoidosis, familial Mediterranean fever, systemic lupus erythematous, intraperitoneal chemotherapy, cirrhosis, liver transplantation, gastrointestinal malignancy, endometriosis, protein S deficiency and fibrogenic foreign material. […] In cirrhotic patients SM has been described after PVS and in those treated with beta-blockers. […] It should also be included in the differential diagnosis in cirrhotic patients with recurrent intraabdominal infection, such as SBP, who present with symptoms of intestinal obstruction. […] However our patient was diagnosed with compensated alcoholic cirrhosis (Child-Pugh A score) and had neither of these conditions.

• #65 Sclerosing Mesenteritis: A Review Article | Insight Medical Publishing

  https://raredisorders.imedpub.com/articles/sclerosing-mesenteritis-a-review-article.php?aid=23602

  Sclerosing mesenteritis is a rare chronic inflammatory condition characterized by mesenteric fibrosis. […] The etiology of sclerosis mesenteritis (SM) is unknown. […] A systematic review by Sharma et al. in 2017 reported that approximately 30% of patients had a history of prior abdominal surgery or trauma. […] Other potential causative factors include infection, ischemia, and neoplasm. […] Autoimmune conditions associated with SM include retroperitoneal fibrosis, sclerosing cholangitis, Riedel thyroiditis, and orbital pseudotumor. […] The pathophysiology of SM is likewise unclear. […] Given the typical presence of foamy macrophages on histopathology, it has been hypothesized that molecular pathways involving foam cell formation, including upregulation of peroxisome proliferator-activated receptor-gamma (PPAR-gamma), may play a role. […] A recent small series of case reports further suggests a relationship between dysfunctional glucose metabolism and the molecular mechanism of SM.

• #66 Sclerosing Mesenteritis: A Review Article | Insight Medical Publishing

  https://raredisorders.imedpub.com/articles/sclerosing-mesenteritis-a-review-article.php?aid=23602

  Sclerosing mesenteritis is a rare chronic inflammatory condition characterized by mesenteric fibrosis. […] The etiology of sclerosis mesenteritis (SM) is unknown. […] A systematic review by Sharma et al. in 2017 reported that approximately 30% of patients had a history of prior abdominal surgery or trauma. […] Other potential causative factors include infection, ischemia, and neoplasm. […] Autoimmune conditions associated with SM include retroperitoneal fibrosis, sclerosing cholangitis, Riedel thyroiditis, and orbital pseudotumor. […] The pathophysiology of SM is likewise unclear. […] Given the typical presence of foamy macrophages on histopathology, it has been hypothesized that molecular pathways involving foam cell formation, including upregulation of peroxisome proliferator-activated receptor-gamma (PPAR-gamma), may play a role. […] A recent small series of case reports further suggests a relationship between dysfunctional glucose metabolism and the molecular mechanism of SM.

• #67 Sclerosing Mesenteritis: Symptoms, Causes & Diagnosis

  https://tap.health/sclerosing-mesenteritis-symptoms/

  The exact cause of sclerosing mesenteritis remains unknown. However, its believed to be linked to inflammation and possibly autoimmune responses. […] While no specific risk factors are definitively established, some studies suggest a possible association with certain infections or autoimmune disorders. […] Sclerosing mesenteritis, a rare inflammatory condition affecting the mesentery (the tissue supporting the intestines), remains somewhat enigmatic in terms of its precise cause. While a definitive trigger isn’t identified, several factors are linked to increased risk. Genetic predisposition is suspected, hinting at a possible hereditary component. Certain underlying conditions, including autoimmune disorders and infections, are also considered potential contributors. […] In regions like India and other tropical countries, specific risk factors may play a more significant role. While research is limited, considering the prevalence of certain conditions is crucial. For instance, chronic infections, prevalent in some areas, could potentially contribute to the development of sclerosing mesenteritis. […] Currently, there’s no known way to definitively prevent sclerosing mesenteritis. However, maintaining a healthy lifestyle, including a balanced diet and regular exercise, can contribute to overall well-being and potentially minimize the risk of developing inflammatory conditions.

• #68 Ultrasonography-based Management of Sclerosing Mesenteritis | IMCRJ

  https://www.dovepress.com/ultrasonography-based-management-of-sclerosing-mesenteritis-from-diagn-peer-reviewed-fulltext-article-IMCRJ

  Sclerosing mesenteritis (SM) is an idiopathic disorder affecting mesentery, characterized by fat necrosis, chronic inflammation and fibrosis. […] Although the etiopathogenesis is still unclear, previous abdominal trauma or surgery, cancer, autoimmunity, infection, and medications have been linked to the development of SM. […] The most common conditions associated with SM are previous abdominal trauma or surgery; in this context, SM might be the result of an abnormal response to healing and repair of connective tissue after trauma or surgery in genetically predisposed subjects. […] Moreover, SM has also been considered a paraneoplastic syndrome, since it is associated with different malignancies, such as lymphomas, chronic lymphocytic leukemia, myeloma, carcinoid, gastrointestinal cancers, renal cancer, and lung cancer. […] SM has been hypothesized to be a progressive inflammatory process, moving from mesenteric lipodystrophy to retractile mesenteritis, triggered by a wide variety of stimuli.

• #69 IgG4-related sclerosing mesenteritis causing bowel obstruction: a case report | Surgical Case Reports | Full Text

  https://surgicalcasereports.springeropen.com/articles/10.1186/s40792-016-0248-0

  Sclerosing mesenteritis (SM) is a rare inflammatory and fibrosing disease primarily involving the small-bowel mesentery. […] The etiology of SM remains undetermined. Suggested causes include trauma (including surgery), powder on surgical gloves, infection (such as tuberculosis), autoimmune diseases, vascular insufficiency, and retained suture material. […] About 40 to 70 % of patients with SM were found to have undergone previous surgery. […] The pathogenic mechanism of SM seems to be a non-specific response to a wide variety of stimuli. […] SM may be an IgG4-RD, diseases that dramatically respond to corticosteroid treatment. […] Although the incidence of SM related to IgG4-RD has not been determined, SM was observed in 2 (4 %) of 57 patients with autoimmune pancreatitis and marked infiltration of IgG4-positive plasma cells was observed in 4 (33 %) of 12 patients with SM.

• #70 Idiopathic Sclerosing Mesenteritis: An Extremely Rare Cause of Mesenteric Mass | Dhruv | Journal of Medical Cases

  https://www.journalmc.org/index.php/JMC/article/view/3825/3177

  Idiopathic sclerosing mesenteritis (ISM) is an extremely rare condition in which mesenteric adipose tissue undergoes necrotic and fibrotic changes. […] Some of the suggested causes of this extremely rare condition include autoimmune disorders, abdominal trauma, malignancy, abdominal infections and even IgG4-related diseases; however, the actual cause remains unknown. […] Several causal factors are suggested like autoimmune disorders, abdominal trauma, malignancy, abdominal infections and even IgG4-related diseases, but the actual cause remains unknown. […] Before terming it as idiopathic sclerosing mesenteritis, common causes like autoimmune diseases, abdominal trauma, and IgG4-related diseases need to be excluded. […] More detailed studies are needed to identify the definite etiology of sclerosing mesenteritis.

• #71 Sclerosing mesenteritis and mesenteric panniculitis – clinical experience and radiological features | BMC Gastroenterology | Full Text

  https://bmcgastroenterol.biomedcentral.com/articles/10.1186/s12876-017-0632-7

  Sclerosing mesenteritis (SM) is sometimes used as an umbrella-term for idiopathic inflammatory conditions in the mesentery. […] A histological study by Emory et al. suggested the use of SM as an umbrella term since they histologically seemed to be one entity and only represented different stages of the same disease. […] The diagnosis is based on histopathology or radiology. […] The suggestion by Emory et al. that MP is a subgroup of SM has not been questioned. […] The condition has earlier been described as benign but the clinical course may vary from no symptoms to severe and aggressive disease. […] In some studies it has been suggested an overrepresentation of SM in patients with malignant disease, although a matched pair analysis has questioned this. […] The first line treatment of SM is corticosteroids but sometimes other immune modulating agents such as Thiopurines and TNF inhibitors have been tried as well as colchicine and thalidomide.

• #72

  https://www.ijsurgery.com/index.php/isj/article/view/14

  The etiology of SM remains unknown, although several mechanisms have been suggested contributors, including surgery or abdominal trauma before, autoimmunity, paraneoplastic syndrome, ischemic injury and infections. […] There is no specific treatment for SM and should this be empirical and individualized.

• #73 Sclerosing Mesenteritis Presenting with Small Bowel Obstruction in a Patient with Compensated Cirrhosis: A Case Report

  https://www.fortunejournals.com/articles/sclerosing-mesenteritis-presenting-with-small-bowel-obstruction-in-a-patient-with-compensated-cirrhosis-a-case-report.html

  Sclerosing Mesenteritis (SM) is a rare fibroinflammatory disease of unknown etiology in which intestinal obstruction results from encasement of variable lengths of bowel by a dense fibrocollagenous membrane that gives the appearance of a cocoon. […] Depending on the etiopathogenesis and the pathological characteristics of the encasing membrane, SM can be classified as primary (idiopathic), secondary or congenital. […] Peritoneal dialysis (PD) is the most common cause of secondary SM. […] Other causes include prior abdominal surgery, beta-blocker treatment, peritoneovenous shunting (PVS) and decompensated cirrhosis complicated by spontaneous bacterial peritonitis (SBP). […] To our knowledge no cases of SM have been reported in patients with compensated cirrhosis without ascites. […] In secondary SM, a local or systemic factor triggers the inflammatory process in the peritoneum.

• #74 Sclerosing mesenteritis | Applied Radiology

  https://appliedradiology.com/articles/sclerosing-mesenteritis

  Sclerosing mesenteritis is a rare, poorly understood benign entity that encompasses a spectrum of mesenteric inflammation and fibrosis. […] This entity is believed to be idiopathic; however, various causes of this entity have been postulated, including ischemic or autoimmune processes. […] The diagnosis is made depending on the extent to which inflammatory or fibrotic components predominate. […] The acute or subacute phase of the disease is termed panniculitis, where fatty degeneration and inflammation is the predominant feature. […] The chronic form, termed retractile mesenteritis, is considered when fibrosis is the dominant feature.

• #75 Sclerosing mesenteritis | Radiology Reference Article | Radiopaedia.org

  https://radiopaedia.org/articles/sclerosing-mesenteritis-1?embed_domain=hackmd.io%25252F%252540yIPUAFeCSL2JsU8smR5nJQ%25252Fbnjhjgjghjghjghfavicon.ico&lang=us

  Sclerosing mesenteritis, also known as mesenteric panniculitis or retractile mesenteritis, is an uncommon idiopathic disorder characterized by chronic non-specific inflammation involving the adipose tissue of the bowel mesentery. […] There is debate about the association between systemic inflammatory conditions and mesenteric panniculitis. Determining causation is difficult. The term „secondary mesenteric panniculitis” is reserved by some authors for patients with systemic inflammatory conditions. Most authors would not use the term when there is a local cause for mesenteric inflammation. […] While local lymphoma (in up to 15% of cases) and a more general association with malignancy of 37-56% have been suggested, a true association has not been proved. In patients diagnosed with mesenteric panniculitis, lymphadenopathy 12 mm, and absence of a 'fat halo’ around lymph nodes and vessels increased the risk of subsequent malignancy diagnosis in one study. Limitations of studies suggesting a malignancy association have been highlighted, and contrary evidence including a systematic review and meta-analysis, and case matched cohort studies have dismissed such an association.

• #76 Treatment options for spontaneous and postoperative sclerosing mesenteritis

  https://www.wjgnet.com/1948-9366/full/v8/i11/761.htm

  Sclerosing mesenteritis is a rare pathology with only a few described cases in the literature. The etiology is unclear; however, several potential triggers, including abdominal surgery and abdominal trauma, have been discussed. […] The etiology is unclear and often remains idiopathic, but abdominal surgical procedures, abdominal trauma, infections, autoimmune processes, drugs, vasculitis, avitaminosis and hypersensitivity have been discussed as potential triggers. […] The pathogenesis of sclerosing mesenteritis remains to be elucidated; however, it seems to be an inflammatory and immune response to local stimuli, such as abdominal surgery or trauma. Moreover, infections, autoimmune processes, malignancy, drugs, vasculitis, avitaminosis and hypersensitivity have been described as potential causes for sclerosing mesenteritis. […] However, the causes for sclerosing mesenteritis often remain idiopathic. […] These case presentations reflect that currently the etiology and the treatment of sclerosing mesenteritis are still not fully understood and further investigations are needed.

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