Materiały źródłowe

• #1 Sclerosing mesenteritis: a comprehensive clinical review

  https://pmc.ncbi.nlm.nih.gov/articles/PMC6174187/

  Sclerosing mesenteritis is a rare disease entity initially described in 1924 with a prevalence reported to be less than 1%. The typical presenting symptom is the abdominal pain, but sclerosing mesenteritis has a broad constellation of presenting symptoms which often makes consideration of the diagnosis unlikely. Chronic uncontrolled inflammation and fibrosis leads to a myriad of gastrointestinal complaints including but not limited to abdominal pain, nausea/vomiting, weight loss, and fever. […] Symptoms of sclerosing mesenteritis are non-specific, and up to 15% of patients can even be completely asymptomatic when it is found on the imaging performed for some other reasons. The most common presenting complaint is abdominal pain. A recently published systematic review of 192 cases of sclerosing mesenteritis revealed the symptomatology as abdominal pain in 78.1%, fever 26.0%, weight loss 22.9%, diarrhea 19.3%, vomiting 18.2%, anorexia 13.5%, constipation 10.9%, bloating 9.4%, malaise 5.7%, nausea 5.7%, pain with eating 4.7%, and fatigue 2.1% of patients. […] The duration of symptoms varies considerably which can be as short as 24 hours or can be as long as ten years.

• #2 Sclerosing mesenteritis: a comprehensive clinical review

  https://atm.amegroups.org/article/view/20473/html

  Sclerosing mesenteritis is a rare disease entity initially described in 1924 with a prevalence reported to be less than 1%. The typical presenting symptom is the abdominal pain, but sclerosing mesenteritis has a broad constellation of presenting symptoms which often makes consideration of the diagnosis unlikely. Chronic uncontrolled inflammation and fibrosis leads to a myriad of gastrointestinal complaints including but not limited to abdominal pain, nausea/vomiting, weight loss, and fever. The most common presenting complaint is abdominal pain. A recently published systematic review of 192 cases of sclerosing mesenteritis revealed the symptomatology as abdominal pain in 78.1%, fever 26.0%, weight loss 22.9%, diarrhea 19.3%, vomiting 18.2%, anorexia 13.5%, constipation 10.9%, bloating 9.4%, malaise 5.7%, nausea 5.7%, pain with eating 4.7%, and fatigue 2.1% of patients. The duration of symptoms varies considerably which can be as short as 24 hours or can be as long as ten years.

• #3 Sclerosing mesenteritis and mesenteric panniculitis – clinical experience and radiological features | BMC Gastroenterology | Full Text

  https://bmcgastroenterol.biomedcentral.com/articles/10.1186/s12876-017-0632-7

  Sclerosing mesenteritis (SM) is a rare but probably underdiagnosed condition of inflammation in the mesentery. […] The clinical course may vary from no symptoms to severe and aggressive disease. […] When symptoms are present they are usually unspecific, such as abdominal pain, nausea, fever and weight loss. […] Five of the 27 patients were asymptomatic, 13 had symptoms without signs of systemic inflammation, five were symptomatic with signs of systemic inflammation and four had severe disease with multiple hospitalisations, chronic, refractory or complicated disease. […] Abdominal pain was reported by 21 patients and was the most common symptom. […] Most symptomatic patients had chronic discomfort but some patients had acute episodes with intense pain, sometimes with mild to moderately elevated CRP levels.

• #4 Mayo Clinic Health Library – Sclerosing mesenteritis | Swiss Medical Network

  https://www.swissmedical.net/en/healtcare-library/con-20213811

  Sclerosing mesenteritis can cause belly pain, vomiting, bloating, diarrhea and fever. But some people experience no symptoms and may never need treatment. […] Symptoms of sclerosing mesenteritis include pain in the belly, vomiting, bloating, diarrhea and fever. Sometimes people don’t have any symptoms. […] In rare cases, scar tissue formed by sclerosing mesenteritis can block food from moving through the digestive tract. In this case, you may need surgery.

• #5 Sclerosing Mesenteritis: Definition, Types & Treatment

  https://my.clevelandclinic.org/health/diseases/15284-sclerosing-mesenteritis

  Sclerosing mesenteritis is a chronic inflammatory condition that affects your mesentery, which is part of your peritoneum. It causes fibrosis (scarring) of the tissues. You may have symptoms of abdominal pain and swelling. […] The most common symptoms people report are abdominal pain and bloating. Severe inflammation may trigger diarrhea or fever. You may be able to feel a palpable mass when you touch your abdomen. In rare cases, a mass may obstruct your small intestine, causing additional symptoms of nausea, vomiting and weight loss. […] For most people, the prognosis (outlook) is good, but it can vary from person to person. Most people have mild to moderate symptoms, if any, but occasionally, it manifests as a more aggressive condition. It can last for a couple of days or as long as 10 years. It often goes away on its own, or with medications, but sometimes it doesn’t. It may take some trial and error to find the treatment that works best for you.

• #6 Sclerosing mesenteritis: a comprehensive clinical review

  https://pmc.ncbi.nlm.nih.gov/articles/PMC6174187/

  Sclerosing mesenteritis is a rare disease entity initially described in 1924 with a prevalence reported to be less than 1%. The typical presenting symptom is the abdominal pain, but sclerosing mesenteritis has a broad constellation of presenting symptoms which often makes consideration of the diagnosis unlikely. Chronic uncontrolled inflammation and fibrosis leads to a myriad of gastrointestinal complaints including but not limited to abdominal pain, nausea/vomiting, weight loss, and fever. […] Symptoms of sclerosing mesenteritis are non-specific, and up to 15% of patients can even be completely asymptomatic when it is found on the imaging performed for some other reasons. The most common presenting complaint is abdominal pain. A recently published systematic review of 192 cases of sclerosing mesenteritis revealed the symptomatology as abdominal pain in 78.1%, fever 26.0%, weight loss 22.9%, diarrhea 19.3%, vomiting 18.2%, anorexia 13.5%, constipation 10.9%, bloating 9.4%, malaise 5.7%, nausea 5.7%, pain with eating 4.7%, and fatigue 2.1% of patients. […] The duration of symptoms varies considerably which can be as short as 24 hours or can be as long as ten years.

• #7 Sclerosing mesenteritis: a comprehensive clinical review

  https://pmc.ncbi.nlm.nih.gov/articles/PMC6174187/

  Sclerosing mesenteritis is a rare disease entity initially described in 1924 with a prevalence reported to be less than 1%. The typical presenting symptom is the abdominal pain, but sclerosing mesenteritis has a broad constellation of presenting symptoms which often makes consideration of the diagnosis unlikely. Chronic uncontrolled inflammation and fibrosis leads to a myriad of gastrointestinal complaints including but not limited to abdominal pain, nausea/vomiting, weight loss, and fever. […] Symptoms of sclerosing mesenteritis are non-specific, and up to 15% of patients can even be completely asymptomatic when it is found on the imaging performed for some other reasons. The most common presenting complaint is abdominal pain. A recently published systematic review of 192 cases of sclerosing mesenteritis revealed the symptomatology as abdominal pain in 78.1%, fever 26.0%, weight loss 22.9%, diarrhea 19.3%, vomiting 18.2%, anorexia 13.5%, constipation 10.9%, bloating 9.4%, malaise 5.7%, nausea 5.7%, pain with eating 4.7%, and fatigue 2.1% of patients. […] The duration of symptoms varies considerably which can be as short as 24 hours or can be as long as ten years.

• #8 Sclerosing Mesenteritis | Abdominal Key

  https://abdominalkey.com/sclerosing-mesenteritis/

  Duration of symptoms, mo (range) N/A (24 h to 2 years) 12 (days to 10 years) N/A. Symptoms, n (%) Abdominal pain 46 (68) 27/78 (35) 65 (70). Diarrhea or constipation 11 (16) N/A 33 (41). Bloating/distension N/A N/A 24 (26). Weight loss 10 (15) N/A 21 (23). Nausea and vomiting 22 (32) N/A 18 (21). Fever 11 (16) N/A 5 (6).

• #9 Sclerosing Mesenteritis: A Rare Cause of Abdominal Pain

  https://pmc.ncbi.nlm.nih.gov/articles/PMC9520956/

  Sclerosing mesenteritis (SM) is a rare inflammatory fibrotic disease of the small intestine mesenteric fat often discovered incidentally on a CT scan. Clinical manifestations depend on the mass effect on the viscera and vessels. The most common symptoms are abdominal pain, bloating, and nausea. […] Patients with SM mainly complain of chronic abdominal pain with other non-specific symptoms like bloating, nausea, vomiting, diarrhea, constipation, and weight loss. […] The most common presenting manifestations are abdominal pain, nausea, vomiting, altered bowel habits, anorexia, and weight loss many of which were present in our patient. […] These symptoms are non-specific and suggest many things as possible differential diagnoses including irritable bowel syndrome. However, anorexia and weight loss would point more towards a neoplastic etiology.

• #10 Sclerosing Mesenteritis | Abdominal Key

  https://abdominalkey.com/sclerosing-mesenteritis/

  Duration of symptoms, mo (range) N/A (24 h to 2 years) 12 (days to 10 years) N/A. Symptoms, n (%) Abdominal pain 46 (68) 27/78 (35) 65 (70). Diarrhea or constipation 11 (16) N/A 33 (41). Bloating/distension N/A N/A 24 (26). Weight loss 10 (15) N/A 21 (23). Nausea and vomiting 22 (32) N/A 18 (21). Fever 11 (16) N/A 5 (6).

• #11 Mayo Clinic Health Library – Sclerosing mesenteritis | Swiss Medical Network

  https://www.swissmedical.net/en/healtcare-library/con-20213811

  Sclerosing mesenteritis can cause belly pain, vomiting, bloating, diarrhea and fever. But some people experience no symptoms and may never need treatment. […] Symptoms of sclerosing mesenteritis include pain in the belly, vomiting, bloating, diarrhea and fever. Sometimes people don’t have any symptoms. […] In rare cases, scar tissue formed by sclerosing mesenteritis can block food from moving through the digestive tract. In this case, you may need surgery.

• #12 Sclerosing mesenteritis: a comprehensive clinical review

  https://pmc.ncbi.nlm.nih.gov/articles/PMC6174187/

  Sclerosing mesenteritis is a rare disease entity initially described in 1924 with a prevalence reported to be less than 1%. The typical presenting symptom is the abdominal pain, but sclerosing mesenteritis has a broad constellation of presenting symptoms which often makes consideration of the diagnosis unlikely. Chronic uncontrolled inflammation and fibrosis leads to a myriad of gastrointestinal complaints including but not limited to abdominal pain, nausea/vomiting, weight loss, and fever. […] Symptoms of sclerosing mesenteritis are non-specific, and up to 15% of patients can even be completely asymptomatic when it is found on the imaging performed for some other reasons. The most common presenting complaint is abdominal pain. A recently published systematic review of 192 cases of sclerosing mesenteritis revealed the symptomatology as abdominal pain in 78.1%, fever 26.0%, weight loss 22.9%, diarrhea 19.3%, vomiting 18.2%, anorexia 13.5%, constipation 10.9%, bloating 9.4%, malaise 5.7%, nausea 5.7%, pain with eating 4.7%, and fatigue 2.1% of patients. […] The duration of symptoms varies considerably which can be as short as 24 hours or can be as long as ten years.

• #13 Sclerosing mesenteritis: a comprehensive clinical review

  https://pmc.ncbi.nlm.nih.gov/articles/PMC6174187/

  Sclerosing mesenteritis is a rare disease entity initially described in 1924 with a prevalence reported to be less than 1%. The typical presenting symptom is the abdominal pain, but sclerosing mesenteritis has a broad constellation of presenting symptoms which often makes consideration of the diagnosis unlikely. Chronic uncontrolled inflammation and fibrosis leads to a myriad of gastrointestinal complaints including but not limited to abdominal pain, nausea/vomiting, weight loss, and fever. […] Symptoms of sclerosing mesenteritis are non-specific, and up to 15% of patients can even be completely asymptomatic when it is found on the imaging performed for some other reasons. The most common presenting complaint is abdominal pain. A recently published systematic review of 192 cases of sclerosing mesenteritis revealed the symptomatology as abdominal pain in 78.1%, fever 26.0%, weight loss 22.9%, diarrhea 19.3%, vomiting 18.2%, anorexia 13.5%, constipation 10.9%, bloating 9.4%, malaise 5.7%, nausea 5.7%, pain with eating 4.7%, and fatigue 2.1% of patients. […] The duration of symptoms varies considerably which can be as short as 24 hours or can be as long as ten years.

• #14 Sclerosing Mesenteritis | Abdominal Key

  https://abdominalkey.com/sclerosing-mesenteritis/

  Duration of symptoms, mo (range) N/A (24 h to 2 years) 12 (days to 10 years) N/A. Symptoms, n (%) Abdominal pain 46 (68) 27/78 (35) 65 (70). Diarrhea or constipation 11 (16) N/A 33 (41). Bloating/distension N/A N/A 24 (26). Weight loss 10 (15) N/A 21 (23). Nausea and vomiting 22 (32) N/A 18 (21). Fever 11 (16) N/A 5 (6).

• #15 Mayo Clinic Health Library – Sclerosing mesenteritis | Swiss Medical Network

  https://www.swissmedical.net/en/healtcare-library/con-20213811

  Sclerosing mesenteritis can cause belly pain, vomiting, bloating, diarrhea and fever. But some people experience no symptoms and may never need treatment. […] Symptoms of sclerosing mesenteritis include pain in the belly, vomiting, bloating, diarrhea and fever. Sometimes people don’t have any symptoms. […] In rare cases, scar tissue formed by sclerosing mesenteritis can block food from moving through the digestive tract. In this case, you may need surgery.

• #16 Sclerosing mesenteritis: a comprehensive clinical review

  https://pmc.ncbi.nlm.nih.gov/articles/PMC6174187/

  Sclerosing mesenteritis is a rare disease entity initially described in 1924 with a prevalence reported to be less than 1%. The typical presenting symptom is the abdominal pain, but sclerosing mesenteritis has a broad constellation of presenting symptoms which often makes consideration of the diagnosis unlikely. Chronic uncontrolled inflammation and fibrosis leads to a myriad of gastrointestinal complaints including but not limited to abdominal pain, nausea/vomiting, weight loss, and fever. […] Symptoms of sclerosing mesenteritis are non-specific, and up to 15% of patients can even be completely asymptomatic when it is found on the imaging performed for some other reasons. The most common presenting complaint is abdominal pain. A recently published systematic review of 192 cases of sclerosing mesenteritis revealed the symptomatology as abdominal pain in 78.1%, fever 26.0%, weight loss 22.9%, diarrhea 19.3%, vomiting 18.2%, anorexia 13.5%, constipation 10.9%, bloating 9.4%, malaise 5.7%, nausea 5.7%, pain with eating 4.7%, and fatigue 2.1% of patients. […] The duration of symptoms varies considerably which can be as short as 24 hours or can be as long as ten years.

• #17 Sclerosing Mesenteritis: A Rare Cause of Abdominal Pain

  https://pmc.ncbi.nlm.nih.gov/articles/PMC9520956/

  Sclerosing mesenteritis (SM) is a rare inflammatory fibrotic disease of the small intestine mesenteric fat often discovered incidentally on a CT scan. Clinical manifestations depend on the mass effect on the viscera and vessels. The most common symptoms are abdominal pain, bloating, and nausea. […] Patients with SM mainly complain of chronic abdominal pain with other non-specific symptoms like bloating, nausea, vomiting, diarrhea, constipation, and weight loss. […] The most common presenting manifestations are abdominal pain, nausea, vomiting, altered bowel habits, anorexia, and weight loss many of which were present in our patient. […] These symptoms are non-specific and suggest many things as possible differential diagnoses including irritable bowel syndrome. However, anorexia and weight loss would point more towards a neoplastic etiology.

• #18 Sclerosing Mesenteritis | Abdominal Key

  https://abdominalkey.com/sclerosing-mesenteritis/

  Duration of symptoms, mo (range) N/A (24 h to 2 years) 12 (days to 10 years) N/A. Symptoms, n (%) Abdominal pain 46 (68) 27/78 (35) 65 (70). Diarrhea or constipation 11 (16) N/A 33 (41). Bloating/distension N/A N/A 24 (26). Weight loss 10 (15) N/A 21 (23). Nausea and vomiting 22 (32) N/A 18 (21). Fever 11 (16) N/A 5 (6).

• #19 Sclerosing mesenteritis: a comprehensive clinical review

  https://atm.amegroups.org/article/view/20473/html

  Sclerosing mesenteritis is a rare disease entity initially described in 1924 with a prevalence reported to be less than 1%. The typical presenting symptom is the abdominal pain, but sclerosing mesenteritis has a broad constellation of presenting symptoms which often makes consideration of the diagnosis unlikely. Chronic uncontrolled inflammation and fibrosis leads to a myriad of gastrointestinal complaints including but not limited to abdominal pain, nausea/vomiting, weight loss, and fever. The most common presenting complaint is abdominal pain. A recently published systematic review of 192 cases of sclerosing mesenteritis revealed the symptomatology as abdominal pain in 78.1%, fever 26.0%, weight loss 22.9%, diarrhea 19.3%, vomiting 18.2%, anorexia 13.5%, constipation 10.9%, bloating 9.4%, malaise 5.7%, nausea 5.7%, pain with eating 4.7%, and fatigue 2.1% of patients. The duration of symptoms varies considerably which can be as short as 24 hours or can be as long as ten years.

• #20 Sclerosing mesenteritis: a comprehensive clinical review

  https://atm.amegroups.org/article/view/20473/html

  Sclerosing mesenteritis is a rare disease entity initially described in 1924 with a prevalence reported to be less than 1%. The typical presenting symptom is the abdominal pain, but sclerosing mesenteritis has a broad constellation of presenting symptoms which often makes consideration of the diagnosis unlikely. Chronic uncontrolled inflammation and fibrosis leads to a myriad of gastrointestinal complaints including but not limited to abdominal pain, nausea/vomiting, weight loss, and fever. The most common presenting complaint is abdominal pain. A recently published systematic review of 192 cases of sclerosing mesenteritis revealed the symptomatology as abdominal pain in 78.1%, fever 26.0%, weight loss 22.9%, diarrhea 19.3%, vomiting 18.2%, anorexia 13.5%, constipation 10.9%, bloating 9.4%, malaise 5.7%, nausea 5.7%, pain with eating 4.7%, and fatigue 2.1% of patients. The duration of symptoms varies considerably which can be as short as 24 hours or can be as long as ten years.

• #21 Sclerosing mesenteritis: a comprehensive clinical review

  https://atm.amegroups.org/article/view/20473/html

  Sclerosing mesenteritis is a rare disease entity initially described in 1924 with a prevalence reported to be less than 1%. The typical presenting symptom is the abdominal pain, but sclerosing mesenteritis has a broad constellation of presenting symptoms which often makes consideration of the diagnosis unlikely. Chronic uncontrolled inflammation and fibrosis leads to a myriad of gastrointestinal complaints including but not limited to abdominal pain, nausea/vomiting, weight loss, and fever. The most common presenting complaint is abdominal pain. A recently published systematic review of 192 cases of sclerosing mesenteritis revealed the symptomatology as abdominal pain in 78.1%, fever 26.0%, weight loss 22.9%, diarrhea 19.3%, vomiting 18.2%, anorexia 13.5%, constipation 10.9%, bloating 9.4%, malaise 5.7%, nausea 5.7%, pain with eating 4.7%, and fatigue 2.1% of patients. The duration of symptoms varies considerably which can be as short as 24 hours or can be as long as ten years.

• #22 Sclerosing Mesenteritis: Definition, Types & Treatment

  https://my.clevelandclinic.org/health/diseases/15284-sclerosing-mesenteritis

  Sclerosing mesenteritis is a chronic inflammatory condition that affects your mesentery, which is part of your peritoneum. It causes fibrosis (scarring) of the tissues. You may have symptoms of abdominal pain and swelling. […] The most common symptoms people report are abdominal pain and bloating. Severe inflammation may trigger diarrhea or fever. You may be able to feel a palpable mass when you touch your abdomen. In rare cases, a mass may obstruct your small intestine, causing additional symptoms of nausea, vomiting and weight loss. […] For most people, the prognosis (outlook) is good, but it can vary from person to person. Most people have mild to moderate symptoms, if any, but occasionally, it manifests as a more aggressive condition. It can last for a couple of days or as long as 10 years. It often goes away on its own, or with medications, but sometimes it doesn’t. It may take some trial and error to find the treatment that works best for you.

• #23 Sclerosing Mesenteritis: Diverse clinical presentations and dissimilar treatment options. A case series and review of the literature | International Archives of Medicine | Full Text

  https://intarchmed.biomedcentral.com/articles/10.1186/1755-7682-4-17

  Sclerosing mesenteritis (SM) is a rare pathological condition affecting the mesentery. The initial clinical presentation varies from typically asymptomatic to that of an acute abdomen. The most common symptoms are abdominal pain, bloating/distension, diarrhea, nausea, vomiting, weight loss, loss of appetite, constipation and altered bowel habit. The disease is often asymptomatic and indeed most patients in any given series were incidentally identified during a CT examination. When present, clinical symptoms are non-specific and protean. The diverse clinical presentation of SM was obvious in our series as well. There were two asymptomatic patients that were accidentally diagnosed as having SM during surgery for an abdominal hernia and cecal cancer respectively. The weight loss reported by one patient could not be attributed to the SM as there was an underlying malignant disease (cecal cancer). The other three patients presented with abdominal pain as the predominant symptom, while there was one patient with fever. It is remarkable that during physical examination, a palpable mass was revealed in all of the patients (100%).

• #24 Sclerosing mesenteritis: a comprehensive clinical review

  https://pmc.ncbi.nlm.nih.gov/articles/PMC6174187/

  Sclerosing mesenteritis is a rare disease entity initially described in 1924 with a prevalence reported to be less than 1%. The typical presenting symptom is the abdominal pain, but sclerosing mesenteritis has a broad constellation of presenting symptoms which often makes consideration of the diagnosis unlikely. Chronic uncontrolled inflammation and fibrosis leads to a myriad of gastrointestinal complaints including but not limited to abdominal pain, nausea/vomiting, weight loss, and fever. […] Symptoms of sclerosing mesenteritis are non-specific, and up to 15% of patients can even be completely asymptomatic when it is found on the imaging performed for some other reasons. The most common presenting complaint is abdominal pain. A recently published systematic review of 192 cases of sclerosing mesenteritis revealed the symptomatology as abdominal pain in 78.1%, fever 26.0%, weight loss 22.9%, diarrhea 19.3%, vomiting 18.2%, anorexia 13.5%, constipation 10.9%, bloating 9.4%, malaise 5.7%, nausea 5.7%, pain with eating 4.7%, and fatigue 2.1% of patients. […] The duration of symptoms varies considerably which can be as short as 24 hours or can be as long as ten years.

• #25 Sclerosing Mesenteritis: Definition, Types & Treatment

  https://my.clevelandclinic.org/health/diseases/15284-sclerosing-mesenteritis

  Sclerosing mesenteritis is a chronic inflammatory condition that affects your mesentery, which is part of your peritoneum. It causes fibrosis (scarring) of the tissues. You may have symptoms of abdominal pain and swelling. […] The most common symptoms people report are abdominal pain and bloating. Severe inflammation may trigger diarrhea or fever. You may be able to feel a palpable mass when you touch your abdomen. In rare cases, a mass may obstruct your small intestine, causing additional symptoms of nausea, vomiting and weight loss. […] For most people, the prognosis (outlook) is good, but it can vary from person to person. Most people have mild to moderate symptoms, if any, but occasionally, it manifests as a more aggressive condition. It can last for a couple of days or as long as 10 years. It often goes away on its own, or with medications, but sometimes it doesn’t. It may take some trial and error to find the treatment that works best for you.

• #26 Sclerosing mesenteritis: a comprehensive clinical review

  https://pmc.ncbi.nlm.nih.gov/articles/PMC6174187/

  Sclerosing mesenteritis is a rare disease entity initially described in 1924 with a prevalence reported to be less than 1%. The typical presenting symptom is the abdominal pain, but sclerosing mesenteritis has a broad constellation of presenting symptoms which often makes consideration of the diagnosis unlikely. Chronic uncontrolled inflammation and fibrosis leads to a myriad of gastrointestinal complaints including but not limited to abdominal pain, nausea/vomiting, weight loss, and fever. […] Symptoms of sclerosing mesenteritis are non-specific, and up to 15% of patients can even be completely asymptomatic when it is found on the imaging performed for some other reasons. The most common presenting complaint is abdominal pain. A recently published systematic review of 192 cases of sclerosing mesenteritis revealed the symptomatology as abdominal pain in 78.1%, fever 26.0%, weight loss 22.9%, diarrhea 19.3%, vomiting 18.2%, anorexia 13.5%, constipation 10.9%, bloating 9.4%, malaise 5.7%, nausea 5.7%, pain with eating 4.7%, and fatigue 2.1% of patients. […] The duration of symptoms varies considerably which can be as short as 24 hours or can be as long as ten years.

• #27 Sclerosing Mesenteritis-Update on Diagnostic and Therapeutic Appr

  https://www.itmedicalteam.pl/articles/sclerosing-mesenteritisupdate-on-diagnostic-and-therapeutic-approach-108510.html

  The sclerosing mesenteritis (SM) is a rare, non-specific inflammatory condition, mainly affecting the benign intestinal mesentery. […] The major signs and symptoms are abdominal pain, presence of palpable abdominal mass, nausea and vomiting, bowel changes, weight loss, small bowel obstruction, chylous ascites and peritoneal irritation signals. […] About of 10% of the patients are asymptomatic. […] Despite the prognosis generally be favorable, about 20% of patients are associated with significant morbidity and a chronic course. […] The clinical presentation of SM is varied and its diagnosis requires a high degree of suspicion, because the disease is usually asymptomatic. […] The major signs and symptoms appear to be associated with inflammation and the adjacent organ mass effect. […] The duration of symptoms ranged from 24 hours to two years, with an average of 6 months, showing a continuous or intermittent character.

• #28 Sclerosing Mesenteritis: A Rare Cause of Abdominal Pain

  https://pmc.ncbi.nlm.nih.gov/articles/PMC9520956/

  Our patient presented with chronic abdominal pain that was initially thought to be irritable bowel syndrome, a much more common disease, and was later diagnosed with SM, a rare disease seen in 0.6% of over 7,000 consecutive patients having abdominal CT scans. […] The patient went for several years with waxing and waning symptoms and in the meantime developed melanoma limited to the skin. Eventually, her symptoms of abdominal pain and nausea increased and she required admission to the hospital where another CT abdomen showed enlarged retroperitoneal lymph nodes with a left para-aortic node that measured 1.9 x 1.7 x 3.9 cm. […] A heightened awareness of this disease may prompt further evaluation, especially in patients with more severe or uncontrolled symptoms.

• #29 Sclerosing Mesenteritis-Update on Diagnostic and Therapeutic Appr

  https://www.itmedicalteam.pl/articles/sclerosing-mesenteritisupdate-on-diagnostic-and-therapeutic-approach-108510.html

  Other signs and symptoms may be present, and generally reflect conditions attached, such as an underlying malignancy. […] The role of the TC is not limited only to the diagnosis of this disease, but also to non-invasive monitoring of the progression of volume and mass, as well as extension of the vascular involvement and identification of potential complications. […] The natural history of sclerosing mesenteritis is not well understood. […] The sclerosing mesenteritis has usually a benign, self-limited course, slowly progressive evolution and resolves spontaneously in most cases, showing a favorable prognosis. […] However, 20% of patients have significant morbidity and a chronic debilitating course. […] A minority of patients have rapid and fatal evolution, and according to some authors, a reasonable percentage developed malignancies during the studies, including lymphoma, carcinoid syndrome, lung adenocarcinoma and mesothelioma.

• #30 Sclerosing Mesenteritis: Diverse clinical presentations and dissimilar treatment options. A case series and review of the literature | International Archives of Medicine | Full Text

  https://intarchmed.biomedcentral.com/articles/10.1186/1755-7682-4-17

  The pathophysiology of SM remains unknown. The pathogenic mechanism seems to be a non-specific response to a wide variety of stimuli. The disease has generally been reported as having a self-limiting benign course with spontaneous remissions being the most favourable outcome. Although the overall prognosis is good, in about 20% of patients, SM is associated with significant morbidity and a chronic debilitating course.

• #31 Sclerosing Mesenteritis-Update on Diagnostic and Therapeutic Appr

  https://www.itmedicalteam.pl/articles/sclerosing-mesenteritisupdate-on-diagnostic-and-therapeutic-approach-108510.html

  Other signs and symptoms may be present, and generally reflect conditions attached, such as an underlying malignancy. […] The role of the TC is not limited only to the diagnosis of this disease, but also to non-invasive monitoring of the progression of volume and mass, as well as extension of the vascular involvement and identification of potential complications. […] The natural history of sclerosing mesenteritis is not well understood. […] The sclerosing mesenteritis has usually a benign, self-limited course, slowly progressive evolution and resolves spontaneously in most cases, showing a favorable prognosis. […] However, 20% of patients have significant morbidity and a chronic debilitating course. […] A minority of patients have rapid and fatal evolution, and according to some authors, a reasonable percentage developed malignancies during the studies, including lymphoma, carcinoid syndrome, lung adenocarcinoma and mesothelioma.

• #32 Sclerosing Mesenteritis-Update on Diagnostic and Therapeutic Appr

  https://www.itmedicalteam.pl/articles/sclerosing-mesenteritisupdate-on-diagnostic-and-therapeutic-approach-108510.html

  Other signs and symptoms may be present, and generally reflect conditions attached, such as an underlying malignancy. […] The role of the TC is not limited only to the diagnosis of this disease, but also to non-invasive monitoring of the progression of volume and mass, as well as extension of the vascular involvement and identification of potential complications. […] The natural history of sclerosing mesenteritis is not well understood. […] The sclerosing mesenteritis has usually a benign, self-limited course, slowly progressive evolution and resolves spontaneously in most cases, showing a favorable prognosis. […] However, 20% of patients have significant morbidity and a chronic debilitating course. […] A minority of patients have rapid and fatal evolution, and according to some authors, a reasonable percentage developed malignancies during the studies, including lymphoma, carcinoid syndrome, lung adenocarcinoma and mesothelioma.

• #33 Sclerosing mesenteritis | Radiology Reference Article | Radiopaedia.org

  https://radiopaedia.org/articles/sclerosing-mesenteritis-1?lang=us

  Sclerosing mesenteritis, also known as mesenteric panniculitis or retractile mesenteritis, is an uncommon idiopathic disorder characterized by chronic non-specific inflammation involving the adipose tissue of the bowel mesentery. […] Clinical presentation can be variable with fever and abdominal pain common. Intestinal obstruction or ischemia, a mass, or diarrhea may also be present. Altered bowel habits and weight loss may be present in some cases. Occasionally, intermittent partial bowel obstruction is encountered. A firm left upper quadrant / central abdominal mass may be felt. In some situations sclerosing mesenteritis is asymptomatic. […] The disease is said to pass through three stages, although some authors believe these to be separate entities: mesenteric lipodystrophy: degeneration of mesenteric fat; mesenteric panniculitis: inflammatory reaction; retractile mesenteritis / sclerosing mesenteritis: fibrosis, which may be associated with distortion or lymphatic obstruction. […] The mainstay of treatment is supportive, as the disease is typically self-limiting. If severe or protracted, medical therapy with corticosteroids, cyclophosphamide or azathioprine can be contemplated. Mesenteric panniculitis cannot be completely resected and surgery is of no benefit.

• #34 Sclerosing mesenteritis: a comprehensive clinical review

  https://atm.amegroups.org/article/view/20473/html

  Although the diagnosis of sclerosing mesenteritis can carry a considerably broad differential, with significant concern for malignancy, often patients have minimal to no symptoms at presentation. If histologic sampling of the tissue is consistent with sclerosing mesenteritis, it seems that patients may be managed with watchful waiting and monitoring for the development of symptoms that may require intervention. […] There has been limited evidence to support that sclerosing mesenteritis is a progressive process moving from lipodystrophy to retractile mesenteritis.

• #35 Sclerosing mesenteritis | Radiology Case | Radiopaedia.org

  https://radiopaedia.org/cases/sclerosing-mesenteritis-6?lang=us

  There are subtypes based on the predominant histopathology, which are shown in their full spectrum in this case: Mesenteric panniculitis (inflammation) at presentation, and retractile mesenteritis (fibrosis) in the 3-year follow-up. This progression is not particularly common or necessarily expected, however. […] Notice the narrowing of the SMV and formation of mesenteric and particularly impressive small bowel wall varices. Venous congestion likely accounts for the pronounced mucosal enhancement of the small bowel and ascites on both studies.

• #36 Sclerosing mesenteritis and mesenteric panniculitis – clinical experience and radiological features | BMC Gastroenterology | Full Text

  https://bmcgastroenterol.biomedcentral.com/articles/10.1186/s12876-017-0632-7

  Sclerosing mesenteritis (SM) is a rare but probably underdiagnosed condition of inflammation in the mesentery. […] The clinical course may vary from no symptoms to severe and aggressive disease. […] When symptoms are present they are usually unspecific, such as abdominal pain, nausea, fever and weight loss. […] Five of the 27 patients were asymptomatic, 13 had symptoms without signs of systemic inflammation, five were symptomatic with signs of systemic inflammation and four had severe disease with multiple hospitalisations, chronic, refractory or complicated disease. […] Abdominal pain was reported by 21 patients and was the most common symptom. […] Most symptomatic patients had chronic discomfort but some patients had acute episodes with intense pain, sometimes with mild to moderately elevated CRP levels.

• #37 Sclerosing mesenteritis and mesenteric panniculitis – clinical experience and radiological features | BMC Gastroenterology | Full Text

  https://bmcgastroenterol.biomedcentral.com/articles/10.1186/s12876-017-0632-7

  Three out of four patients had severe disease with clinical score four and one had clinical score three. […] All patients had abdominal pain, fever, small amounts of ascites and elevated CRP. […] The SM patients had more extensive inflammation that involved extra intestinal tissue in multiple compartments in the abdomen and had a radiological appearance different from that of MP. […] The radiological changes seen in the SM group did not at any point of the disease course resemble MP and presented with a pronounced fluctuation that could not be observed in MP. […] They all had aggressive disease with laboratory and clinical signs of extensive systemic inflammation, whereas the MP group usually had normal and in few cases mild systemic inflammation.

• #38 Sclerosing Mesenteritis | Radiology Key

  https://radiologykey.com/sclerosing-mesenteritis-2/

  Misty mesentery: Increased attenuation of mesentery with fat stranding and induration […] Most patients have stable or slowly progressing disease without symptoms […] Common complications in chronic phase include bowel obstruction, urinary tract obstruction, and bowel ischemia […] This case illustrates progression of the disease over time.

• #39 Sclerosing Mesenteritis: Definition, Types & Treatment

  https://my.clevelandclinic.org/health/diseases/15284-sclerosing-mesenteritis

  Sclerosing mesenteritis is a chronic inflammatory condition that affects your mesentery, which is part of your peritoneum. It causes fibrosis (scarring) of the tissues. You may have symptoms of abdominal pain and swelling. […] The most common symptoms people report are abdominal pain and bloating. Severe inflammation may trigger diarrhea or fever. You may be able to feel a palpable mass when you touch your abdomen. In rare cases, a mass may obstruct your small intestine, causing additional symptoms of nausea, vomiting and weight loss. […] For most people, the prognosis (outlook) is good, but it can vary from person to person. Most people have mild to moderate symptoms, if any, but occasionally, it manifests as a more aggressive condition. It can last for a couple of days or as long as 10 years. It often goes away on its own, or with medications, but sometimes it doesn’t. It may take some trial and error to find the treatment that works best for you.

• #40 Mayo Clinic Health Library – Sclerosing mesenteritis | Swiss Medical Network

  https://www.swissmedical.net/en/healtcare-library/con-20213811

  Sclerosing mesenteritis can cause belly pain, vomiting, bloating, diarrhea and fever. But some people experience no symptoms and may never need treatment. […] Symptoms of sclerosing mesenteritis include pain in the belly, vomiting, bloating, diarrhea and fever. Sometimes people don’t have any symptoms. […] In rare cases, scar tissue formed by sclerosing mesenteritis can block food from moving through the digestive tract. In this case, you may need surgery.

• #41 Sclerosing Mesenteritis | Radiology Key

  https://radiologykey.com/sclerosing-mesenteritis-2/

  Misty mesentery: Increased attenuation of mesentery with fat stranding and induration […] Most patients have stable or slowly progressing disease without symptoms […] Common complications in chronic phase include bowel obstruction, urinary tract obstruction, and bowel ischemia […] This case illustrates progression of the disease over time.

• #42 A Clinical Review of Mesenteric Panniculitis – Gastroenterology & Hepatology

  https://www.gastroenterologyandhepatology.net/archives/april-2023/a-clinical-review-of-mesenteric-panniculitis/

  Although MP usually presents with a benign disease course, complications can occur because of the mass effect on adjacent structures causing bowel, lymphatic, or vascular obstruction. A large series of patients with MP (n=92) found that 28% presented with small bowel obstruction, 14% had chylous ascites, and 3% had superior mesenteric vein thrombosis. Over a 21-month follow-up period, there were 18 deaths, with 17% occurring from complications attributable to MP or its treatment. Although the overall prognosis of MP is good, this study found that MP was associated with significant morbidity in nearly 20% of patients. […] Also, MP has been proposed to be a progressive inflammatory process, starting from mesenteric lipodystrophy to retractile mesenteritis, triggered by a wide variety of stimuli, such as thermal or chemical injuries, vasculitis, avitaminosis, autoimmune disease, pancreatitis, bile or urine leakage, hypersensitivity reactions, and even bacterial infections. However, there is scarce evidence to demonstrate histologic progression of the disease.

• #43 A Clinical Review of Mesenteric Panniculitis – Gastroenterology & Hepatology

  https://www.gastroenterologyandhepatology.net/archives/april-2023/a-clinical-review-of-mesenteric-panniculitis/

  Although MP usually presents with a benign disease course, complications can occur because of the mass effect on adjacent structures causing bowel, lymphatic, or vascular obstruction. A large series of patients with MP (n=92) found that 28% presented with small bowel obstruction, 14% had chylous ascites, and 3% had superior mesenteric vein thrombosis. Over a 21-month follow-up period, there were 18 deaths, with 17% occurring from complications attributable to MP or its treatment. Although the overall prognosis of MP is good, this study found that MP was associated with significant morbidity in nearly 20% of patients. […] Also, MP has been proposed to be a progressive inflammatory process, starting from mesenteric lipodystrophy to retractile mesenteritis, triggered by a wide variety of stimuli, such as thermal or chemical injuries, vasculitis, avitaminosis, autoimmune disease, pancreatitis, bile or urine leakage, hypersensitivity reactions, and even bacterial infections. However, there is scarce evidence to demonstrate histologic progression of the disease.

• #44 Sclerosing mesenteritis – UpToDate

  https://www.uptodate.com/contents/sclerosing-mesenteritis

  Sclerosing mesenteritis is a rare, non-neoplastic inflammatory and fibrotic disease that affects the mesentery. Sclerosing mesenteritis can result in a variety of gastrointestinal and systemic manifestations, including abdominal pain, nausea and vomiting, diarrhea, weight loss, and fever. […] Sclerosing mesenteritis appears to be rare, and a significant proportion of patients are asymptomatic. […] Sclerosing mesenteritis can affect the integrity of the gastrointestinal lumen and mesenteric vessels by a mass effect. […] In a systematic review of the published literature, previous abdominal surgery or abdominal trauma was described in almost 30 percent of patients.

• #45 Idiopathic sclerosing mesenteritis presenting with small bowel volvulus in a patient with antiphospholipid syndrome: A case report

  https://www.wjgnet.com/2307-8960/full/v11/i14/3304.htm

  The etiology of sclerosing mesenteritis is unclear; however, it is generally associated with chronic inflammation of mesenteric tissue. This may be caused by previous abdominal surgery, trauma, mesenteric ischemia, cancer, infection, or autoimmune disease. […] Symptomatic patients with unclear etiology should be considered for treatment with immunosuppressive medications. In addition, while rare, chronic thrombotic conditions can also cause sclerosing mesenteritis, and they should also be considered.

• #46 Sclerosing mesenteritis – UpToDate

  https://www.uptodate.com/contents/sclerosing-mesenteritis

  Sclerosing mesenteritis is a rare, non-neoplastic inflammatory and fibrotic disease that affects the mesentery. Sclerosing mesenteritis can result in a variety of gastrointestinal and systemic manifestations, including abdominal pain, nausea and vomiting, diarrhea, weight loss, and fever. […] Sclerosing mesenteritis appears to be rare, and a significant proportion of patients are asymptomatic. […] Sclerosing mesenteritis can affect the integrity of the gastrointestinal lumen and mesenteric vessels by a mass effect. […] In a systematic review of the published literature, previous abdominal surgery or abdominal trauma was described in almost 30 percent of patients.

• #47 Sclerosing mesenteritis – UpToDate

  https://www.uptodate.com/contents/sclerosing-mesenteritis/print

  Sclerosing mesenteritis can result in a variety of gastrointestinal and systemic manifestations, including abdominal pain, nausea and vomiting, diarrhea, weight loss, and fever. […] Sclerosing mesenteritis appears to be rare, and a significant proportion of patients are asymptomatic. […] The low prevalence in childhood and adolescence may be attributable to a smaller amount of mesenteric fat. […] Sclerosing mesenteritis has been reported in association with both acute abdominal injury and chronic repetitive trauma (eg, pneumatic jackhammer) and inflammation (eg, occult ileal perforation).

• #48 Idiopathic sclerosing mesenteritis presenting with small bowel volvulus in a patient with antiphospholipid syndrome: A case report

  https://www.wjgnet.com/2307-8960/full/v11/i14/3304.htm

  The etiology of sclerosing mesenteritis is unclear; however, it is generally associated with chronic inflammation of mesenteric tissue. This may be caused by previous abdominal surgery, trauma, mesenteric ischemia, cancer, infection, or autoimmune disease. […] Symptomatic patients with unclear etiology should be considered for treatment with immunosuppressive medications. In addition, while rare, chronic thrombotic conditions can also cause sclerosing mesenteritis, and they should also be considered.

• #49 A Clinical Review of Mesenteric Panniculitis – Gastroenterology & Hepatology

  https://www.gastroenterologyandhepatology.net/archives/april-2023/a-clinical-review-of-mesenteric-panniculitis/

  Although MP usually presents with a benign disease course, complications can occur because of the mass effect on adjacent structures causing bowel, lymphatic, or vascular obstruction. A large series of patients with MP (n=92) found that 28% presented with small bowel obstruction, 14% had chylous ascites, and 3% had superior mesenteric vein thrombosis. Over a 21-month follow-up period, there were 18 deaths, with 17% occurring from complications attributable to MP or its treatment. Although the overall prognosis of MP is good, this study found that MP was associated with significant morbidity in nearly 20% of patients. […] Also, MP has been proposed to be a progressive inflammatory process, starting from mesenteric lipodystrophy to retractile mesenteritis, triggered by a wide variety of stimuli, such as thermal or chemical injuries, vasculitis, avitaminosis, autoimmune disease, pancreatitis, bile or urine leakage, hypersensitivity reactions, and even bacterial infections. However, there is scarce evidence to demonstrate histologic progression of the disease.

• #50 A Clinical Review of Mesenteric Panniculitis – Gastroenterology & Hepatology

  https://www.gastroenterologyandhepatology.net/archives/april-2023/a-clinical-review-of-mesenteric-panniculitis/

  Although MP usually presents with a benign disease course, complications can occur because of the mass effect on adjacent structures causing bowel, lymphatic, or vascular obstruction. A large series of patients with MP (n=92) found that 28% presented with small bowel obstruction, 14% had chylous ascites, and 3% had superior mesenteric vein thrombosis. Over a 21-month follow-up period, there were 18 deaths, with 17% occurring from complications attributable to MP or its treatment. Although the overall prognosis of MP is good, this study found that MP was associated with significant morbidity in nearly 20% of patients. […] Also, MP has been proposed to be a progressive inflammatory process, starting from mesenteric lipodystrophy to retractile mesenteritis, triggered by a wide variety of stimuli, such as thermal or chemical injuries, vasculitis, avitaminosis, autoimmune disease, pancreatitis, bile or urine leakage, hypersensitivity reactions, and even bacterial infections. However, there is scarce evidence to demonstrate histologic progression of the disease.

• #51 Idiopathic sclerosing mesenteritis presenting with small bowel volvulus in a patient with antiphospholipid syndrome: A case report

  https://www.wjgnet.com/2307-8960/full/v11/i14/3304.htm

  The etiology of sclerosing mesenteritis is unclear; however, it is generally associated with chronic inflammation of mesenteric tissue. This may be caused by previous abdominal surgery, trauma, mesenteric ischemia, cancer, infection, or autoimmune disease. […] Symptomatic patients with unclear etiology should be considered for treatment with immunosuppressive medications. In addition, while rare, chronic thrombotic conditions can also cause sclerosing mesenteritis, and they should also be considered.

• #52 Sclerosing Mesenteritis Symptoms, Doctors, Treatments, Advances & More | MediFind

  https://www.medifind.com/conditions/sclerosing-mesenteritis/4765

  Sclerosing mesenteritis is one of many terms that describes a spectrum of inflammatory disorders that affect the mesentery. The condition mostly affects men between their 40s and 60s, but women and children can also be affected. It may result in a variety of symptoms including abdominal pain, nausea and vomiting, constipation or diarrhea, weight loss, and fever. Some people have an abdominal mass. […] The cause of the condition is poorly understood. Suggested possible causes have included previous abdominal surgery or trauma, autoimmunity, paraneoplastic syndromes, ischemic injury, and infection.

• #53 Sclerosing mesenteritis – UpToDate

  https://www.uptodate.com/contents/sclerosing-mesenteritis

  Sclerosing mesenteritis is a rare, non-neoplastic inflammatory and fibrotic disease that affects the mesentery. Sclerosing mesenteritis can result in a variety of gastrointestinal and systemic manifestations, including abdominal pain, nausea and vomiting, diarrhea, weight loss, and fever. […] Sclerosing mesenteritis appears to be rare, and a significant proportion of patients are asymptomatic. […] Sclerosing mesenteritis can affect the integrity of the gastrointestinal lumen and mesenteric vessels by a mass effect. […] In a systematic review of the published literature, previous abdominal surgery or abdominal trauma was described in almost 30 percent of patients.

• #54 Sclerosing Mesenteritis: A Rare Cause of Abdominal Pain

  https://pmc.ncbi.nlm.nih.gov/articles/PMC9520956/

  Sclerosing mesenteritis (SM) is a rare inflammatory fibrotic disease of the small intestine mesenteric fat often discovered incidentally on a CT scan. Clinical manifestations depend on the mass effect on the viscera and vessels. The most common symptoms are abdominal pain, bloating, and nausea. […] Patients with SM mainly complain of chronic abdominal pain with other non-specific symptoms like bloating, nausea, vomiting, diarrhea, constipation, and weight loss. […] The most common presenting manifestations are abdominal pain, nausea, vomiting, altered bowel habits, anorexia, and weight loss many of which were present in our patient. […] These symptoms are non-specific and suggest many things as possible differential diagnoses including irritable bowel syndrome. However, anorexia and weight loss would point more towards a neoplastic etiology.

• #55 Sclerosing Mesenteritis-Update on Diagnostic and Therapeutic Appr

  https://www.itmedicalteam.pl/articles/sclerosing-mesenteritisupdate-on-diagnostic-and-therapeutic-approach-108510.html

  The sclerosing mesenteritis (SM) is a rare, non-specific inflammatory condition, mainly affecting the benign intestinal mesentery. […] The major signs and symptoms are abdominal pain, presence of palpable abdominal mass, nausea and vomiting, bowel changes, weight loss, small bowel obstruction, chylous ascites and peritoneal irritation signals. […] About of 10% of the patients are asymptomatic. […] Despite the prognosis generally be favorable, about 20% of patients are associated with significant morbidity and a chronic course. […] The clinical presentation of SM is varied and its diagnosis requires a high degree of suspicion, because the disease is usually asymptomatic. […] The major signs and symptoms appear to be associated with inflammation and the adjacent organ mass effect. […] The duration of symptoms ranged from 24 hours to two years, with an average of 6 months, showing a continuous or intermittent character.

• #56 Idiopathic sclerosing mesenteritis in the pediatric patient: A case report | Revista de Gastroenterología de México

  https://www.revistagastroenterologiamexico.org/en-idiopathic-sclerosing-mesenteritis-in-pediatric-articulo-S2255534X14000024

  The patients with a greater inflammatory component, with fever, weight loss, and general malaise appear to be the most receptive to glucocorticoids, alone or in combination. In the case of our patient, the use of the steroid and cyclophosphamide had favorable results in disease improvement and modulation.

• #57 Sclerosing mesenteritis and mesenteric panniculitis – clinical experience and radiological features | BMC Gastroenterology | Full Text

  https://bmcgastroenterol.biomedcentral.com/articles/10.1186/s12876-017-0632-7

  Three out of four patients had severe disease with clinical score four and one had clinical score three. […] All patients had abdominal pain, fever, small amounts of ascites and elevated CRP. […] The SM patients had more extensive inflammation that involved extra intestinal tissue in multiple compartments in the abdomen and had a radiological appearance different from that of MP. […] The radiological changes seen in the SM group did not at any point of the disease course resemble MP and presented with a pronounced fluctuation that could not be observed in MP. […] They all had aggressive disease with laboratory and clinical signs of extensive systemic inflammation, whereas the MP group usually had normal and in few cases mild systemic inflammation.

• #58 Idiopathic sclerosing mesenteritis in the pediatric patient: A case report | Revista de Gastroenterología de México

  https://www.revistagastroenterologiamexico.org/en-idiopathic-sclerosing-mesenteritis-in-pediatric-articulo-S2255534X14000024

  The patients with a greater inflammatory component, with fever, weight loss, and general malaise appear to be the most receptive to glucocorticoids, alone or in combination. In the case of our patient, the use of the steroid and cyclophosphamide had favorable results in disease improvement and modulation.

• #59 Sclerosing Mesenteritis-Update on Diagnostic and Therapeutic Appr

  https://www.itmedicalteam.pl/articles/sclerosing-mesenteritisupdate-on-diagnostic-and-therapeutic-approach-108510.html

  Other signs and symptoms may be present, and generally reflect conditions attached, such as an underlying malignancy. […] The role of the TC is not limited only to the diagnosis of this disease, but also to non-invasive monitoring of the progression of volume and mass, as well as extension of the vascular involvement and identification of potential complications. […] The natural history of sclerosing mesenteritis is not well understood. […] The sclerosing mesenteritis has usually a benign, self-limited course, slowly progressive evolution and resolves spontaneously in most cases, showing a favorable prognosis. […] However, 20% of patients have significant morbidity and a chronic debilitating course. […] A minority of patients have rapid and fatal evolution, and according to some authors, a reasonable percentage developed malignancies during the studies, including lymphoma, carcinoid syndrome, lung adenocarcinoma and mesothelioma.

• #60 Sclerosing mesenteritis:an uncommon cause of chronic abdominal pain – MedCrave online

  https://medcraveonline.com/GHOA/sclerosing-mesenteritisan-uncommon-cause-of-chronic-abdominal-pain.html

  Majority of the patients have elevated C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR). […] The usual CT scan findings are mesenteric lymphadenopathy, fat sparing the mesenteric vessels also known are fat sparing sign, hazy mesenteric fat and separation of mesenteric vessels, increased thickness of the involved mesentery, and well or poorly defined mesenteric mass, pseudo capsule (soft-tissue surrounding the inflamed mass). […] Our patient had surgery for repair of the hernia but not all the affected mesenteries were removed. […] Several months after the diagnosis, he had a comfortable life with on and off mild abdominal pain which was resolved by ibuprofen. […] Finally, SM is a rare care of chronic abdominal pain. Though most of the cases are benign like ours, they can be associated with underlying malignancy which need to be ruled out.

• #61 Sclerosing mesenteritis | Radiology Case | Radiopaedia.org

  https://radiopaedia.org/cases/sclerosing-mesenteritis-6?lang=us

  Abdominal pain. […] Hazy mass at the root of the mesentery. Pseudocapsule and fat ring sign on the axial images. Diffuse mucosal hyperenhancement of small bowel, likely related to venous congestion, as the SMV is abruptly narrowed as it enters the mass (best seen on coronal images). Small bowel varices are starting to form. Ascites. […] Progressive fibrosis of the mesenteric root over 3 years. Retracted soft tissue mass with punctuate calcifications at the root of the mesentery. Occlusion of the SMV and extensive small bowel wall varices (best seen on coronal). Ascites. […] Sclerosing mesenteritis is idiopathic, chronic inflammation of the mesentery. The specific cause is unclear but there are associations with surgery, trauma, autoimmune disorders, vasculitis, infection, and malignancy. There can be a relation to IgG4 sclerosis disease.

• #62 Sclerosing mesenteritis | Radiology Case | Radiopaedia.org

  https://radiopaedia.org/cases/sclerosing-mesenteritis-6?lang=us

  Abdominal pain. […] Hazy mass at the root of the mesentery. Pseudocapsule and fat ring sign on the axial images. Diffuse mucosal hyperenhancement of small bowel, likely related to venous congestion, as the SMV is abruptly narrowed as it enters the mass (best seen on coronal images). Small bowel varices are starting to form. Ascites. […] Progressive fibrosis of the mesenteric root over 3 years. Retracted soft tissue mass with punctuate calcifications at the root of the mesentery. Occlusion of the SMV and extensive small bowel wall varices (best seen on coronal). Ascites. […] Sclerosing mesenteritis is idiopathic, chronic inflammation of the mesentery. The specific cause is unclear but there are associations with surgery, trauma, autoimmune disorders, vasculitis, infection, and malignancy. There can be a relation to IgG4 sclerosis disease.

• #63 Sclerosing mesenteritis | Radiology Case | Radiopaedia.org

  https://radiopaedia.org/cases/sclerosing-mesenteritis-6?lang=us

  There are subtypes based on the predominant histopathology, which are shown in their full spectrum in this case: Mesenteric panniculitis (inflammation) at presentation, and retractile mesenteritis (fibrosis) in the 3-year follow-up. This progression is not particularly common or necessarily expected, however. […] Notice the narrowing of the SMV and formation of mesenteric and particularly impressive small bowel wall varices. Venous congestion likely accounts for the pronounced mucosal enhancement of the small bowel and ascites on both studies.

• #64 Sclerosing mesenteritis and mesenteric panniculitis – clinical experience and radiological features | BMC Gastroenterology | Full Text

  https://bmcgastroenterol.biomedcentral.com/articles/10.1186/s12876-017-0632-7

  Three out of four patients had severe disease with clinical score four and one had clinical score three. […] All patients had abdominal pain, fever, small amounts of ascites and elevated CRP. […] The SM patients had more extensive inflammation that involved extra intestinal tissue in multiple compartments in the abdomen and had a radiological appearance different from that of MP. […] The radiological changes seen in the SM group did not at any point of the disease course resemble MP and presented with a pronounced fluctuation that could not be observed in MP. […] They all had aggressive disease with laboratory and clinical signs of extensive systemic inflammation, whereas the MP group usually had normal and in few cases mild systemic inflammation.

• #65 Sclerosing Mesenteritis-Update on Diagnostic and Therapeutic Appr

  https://www.itmedicalteam.pl/articles/sclerosing-mesenteritisupdate-on-diagnostic-and-therapeutic-approach-108510.html

  Other signs and symptoms may be present, and generally reflect conditions attached, such as an underlying malignancy. […] The role of the TC is not limited only to the diagnosis of this disease, but also to non-invasive monitoring of the progression of volume and mass, as well as extension of the vascular involvement and identification of potential complications. […] The natural history of sclerosing mesenteritis is not well understood. […] The sclerosing mesenteritis has usually a benign, self-limited course, slowly progressive evolution and resolves spontaneously in most cases, showing a favorable prognosis. […] However, 20% of patients have significant morbidity and a chronic debilitating course. […] A minority of patients have rapid and fatal evolution, and according to some authors, a reasonable percentage developed malignancies during the studies, including lymphoma, carcinoid syndrome, lung adenocarcinoma and mesothelioma.

• #66 Sclerosing Mesenteritis: A Rare Cause of Abdominal Pain

  https://pmc.ncbi.nlm.nih.gov/articles/PMC9520956/

  Our patient presented with chronic abdominal pain that was initially thought to be irritable bowel syndrome, a much more common disease, and was later diagnosed with SM, a rare disease seen in 0.6% of over 7,000 consecutive patients having abdominal CT scans. […] The patient went for several years with waxing and waning symptoms and in the meantime developed melanoma limited to the skin. Eventually, her symptoms of abdominal pain and nausea increased and she required admission to the hospital where another CT abdomen showed enlarged retroperitoneal lymph nodes with a left para-aortic node that measured 1.9 x 1.7 x 3.9 cm. […] A heightened awareness of this disease may prompt further evaluation, especially in patients with more severe or uncontrolled symptoms.

• #67 Sclerosing Mesenteritis: A Rare Cause of Abdominal Pain

  https://pmc.ncbi.nlm.nih.gov/articles/PMC9520956/

  Our patient presented with chronic abdominal pain that was initially thought to be irritable bowel syndrome, a much more common disease, and was later diagnosed with SM, a rare disease seen in 0.6% of over 7,000 consecutive patients having abdominal CT scans. […] The patient went for several years with waxing and waning symptoms and in the meantime developed melanoma limited to the skin. Eventually, her symptoms of abdominal pain and nausea increased and she required admission to the hospital where another CT abdomen showed enlarged retroperitoneal lymph nodes with a left para-aortic node that measured 1.9 x 1.7 x 3.9 cm. […] A heightened awareness of this disease may prompt further evaluation, especially in patients with more severe or uncontrolled symptoms.

• #68 Sclerosing mesenteritis: a comprehensive clinical review

  https://atm.amegroups.org/article/view/20473/html

  Although the diagnosis of sclerosing mesenteritis can carry a considerably broad differential, with significant concern for malignancy, often patients have minimal to no symptoms at presentation. If histologic sampling of the tissue is consistent with sclerosing mesenteritis, it seems that patients may be managed with watchful waiting and monitoring for the development of symptoms that may require intervention. […] There has been limited evidence to support that sclerosing mesenteritis is a progressive process moving from lipodystrophy to retractile mesenteritis.

• #69 Sclerosing mesenteritis // Middlesex Health

  https://middlesexhealth.org/learning-center/diseases-and-conditions/sclerosing-mesenteritis

  Sclerosing mesenteritis can cause belly pain, vomiting, bloating, diarrhea and fever. But some people experience no symptoms and may never need treatment. […] Symptoms of sclerosing mesenteritis include pain in the belly, vomiting, bloating, diarrhea and fever. Sometimes people don’t have any symptoms. […] If you begin to experience symptoms of sclerosing mesenteritis, you may choose to begin treatment.

• #70 Sclerosing mesenteritis | Radiology Reference Article | Radiopaedia.org

  https://radiopaedia.org/articles/sclerosing-mesenteritis-1?lang=us

  Sclerosing mesenteritis, also known as mesenteric panniculitis or retractile mesenteritis, is an uncommon idiopathic disorder characterized by chronic non-specific inflammation involving the adipose tissue of the bowel mesentery. […] Clinical presentation can be variable with fever and abdominal pain common. Intestinal obstruction or ischemia, a mass, or diarrhea may also be present. Altered bowel habits and weight loss may be present in some cases. Occasionally, intermittent partial bowel obstruction is encountered. A firm left upper quadrant / central abdominal mass may be felt. In some situations sclerosing mesenteritis is asymptomatic. […] The disease is said to pass through three stages, although some authors believe these to be separate entities: mesenteric lipodystrophy: degeneration of mesenteric fat; mesenteric panniculitis: inflammatory reaction; retractile mesenteritis / sclerosing mesenteritis: fibrosis, which may be associated with distortion or lymphatic obstruction. […] The mainstay of treatment is supportive, as the disease is typically self-limiting. If severe or protracted, medical therapy with corticosteroids, cyclophosphamide or azathioprine can be contemplated. Mesenteric panniculitis cannot be completely resected and surgery is of no benefit.

• #71 Sclerosing mesenteritis | Radiology Reference Article | Radiopaedia.org

  https://radiopaedia.org/articles/sclerosing-mesenteritis-1?lang=us

  Sclerosing mesenteritis, also known as mesenteric panniculitis or retractile mesenteritis, is an uncommon idiopathic disorder characterized by chronic non-specific inflammation involving the adipose tissue of the bowel mesentery. […] Clinical presentation can be variable with fever and abdominal pain common. Intestinal obstruction or ischemia, a mass, or diarrhea may also be present. Altered bowel habits and weight loss may be present in some cases. Occasionally, intermittent partial bowel obstruction is encountered. A firm left upper quadrant / central abdominal mass may be felt. In some situations sclerosing mesenteritis is asymptomatic. […] The disease is said to pass through three stages, although some authors believe these to be separate entities: mesenteric lipodystrophy: degeneration of mesenteric fat; mesenteric panniculitis: inflammatory reaction; retractile mesenteritis / sclerosing mesenteritis: fibrosis, which may be associated with distortion or lymphatic obstruction. […] The mainstay of treatment is supportive, as the disease is typically self-limiting. If severe or protracted, medical therapy with corticosteroids, cyclophosphamide or azathioprine can be contemplated. Mesenteric panniculitis cannot be completely resected and surgery is of no benefit.

• #72 Idiopathic sclerosing mesenteritis – Wikipedia

  https://en.wikipedia.org/wiki/Idiopathic_sclerosing_mesenteritis

  Sclerosing mesenteritis may present with no or nearly no signs or symptoms, but many people have chronic and severe pain in the abdomen as the most common chief complaint. Other people have chronic problems with bowel movements, resulting in diarrhea, bloating, gas, and cramping which can range from severe to mild. […] The Mayo Clinic in Rochester reported a large study of 92 patients, with widely ranging severity of their symptoms. The majority were male, with an average age of 65 years. They commonly had abdominal pain (70%), diarrhea (25%), and weight loss (23%). Depending on the stage of the scarring and fibrosis, several different treatments, including surgery for bowel obstruction, or drugs were used to halt the progression of the disease. […] Their findings suggest that sclerosing mesenteritis can be debilitating although relatively benign. Symptomatic patients benefited from medical therapy, usually tamoxifen and prednisone, but further follow-up information would strengthen these results.

• #73

  https://journals.lww.com/ajg/abstract/2019/10001/2060_sclerosing_mesenteritis_treated_successfully.2061.aspx

  Sclerosing Mesenteritis is a rare, non-neoplastic, inflammatory condition that affects the mesentery. It typically presents with a variety of gastrointestinal symptoms such as abdominal pain, nausea, vomiting, and diarrhea, but is largely variable. […] A 45-year-old male presented with intermittent left upper quadrant pain with associated nausea, vomiting, and diarrhea. […] The patient was induced with a 520 milligram dose IV and continued on 90 milligram dose SQ every 8 weeks, leading to complete resolution of his symptoms. […] This case highlights successful utilization of infliximab and ustekinumab for steroid-dependent sclerosing mesenteritis.

• #74 Idiopathic sclerosing mesenteritis – Wikipedia

  https://en.wikipedia.org/wiki/Idiopathic_sclerosing_mesenteritis

  Sclerosing mesenteritis may present with no or nearly no signs or symptoms, but many people have chronic and severe pain in the abdomen as the most common chief complaint. Other people have chronic problems with bowel movements, resulting in diarrhea, bloating, gas, and cramping which can range from severe to mild. […] The Mayo Clinic in Rochester reported a large study of 92 patients, with widely ranging severity of their symptoms. The majority were male, with an average age of 65 years. They commonly had abdominal pain (70%), diarrhea (25%), and weight loss (23%). Depending on the stage of the scarring and fibrosis, several different treatments, including surgery for bowel obstruction, or drugs were used to halt the progression of the disease. […] Their findings suggest that sclerosing mesenteritis can be debilitating although relatively benign. Symptomatic patients benefited from medical therapy, usually tamoxifen and prednisone, but further follow-up information would strengthen these results.

• #75

  https://journals.lww.com/ajg/abstract/2019/10001/2060_sclerosing_mesenteritis_treated_successfully.2061.aspx

  Sclerosing Mesenteritis is a rare, non-neoplastic, inflammatory condition that affects the mesentery. It typically presents with a variety of gastrointestinal symptoms such as abdominal pain, nausea, vomiting, and diarrhea, but is largely variable. […] A 45-year-old male presented with intermittent left upper quadrant pain with associated nausea, vomiting, and diarrhea. […] The patient was induced with a 520 milligram dose IV and continued on 90 milligram dose SQ every 8 weeks, leading to complete resolution of his symptoms. […] This case highlights successful utilization of infliximab and ustekinumab for steroid-dependent sclerosing mesenteritis.

• #76 Mayo Clinic Health Library – Sclerosing mesenteritis | Swiss Medical Network

  https://www.swissmedical.net/en/healtcare-library/con-20213811

  Sclerosing mesenteritis can cause belly pain, vomiting, bloating, diarrhea and fever. But some people experience no symptoms and may never need treatment. […] Symptoms of sclerosing mesenteritis include pain in the belly, vomiting, bloating, diarrhea and fever. Sometimes people don’t have any symptoms. […] In rare cases, scar tissue formed by sclerosing mesenteritis can block food from moving through the digestive tract. In this case, you may need surgery.

• #77 Sclerosing mesenteritis

  https://www.mymlc.com/health-information/diseases-and-conditions/s/sclerosing-mesenteritis/

  Sclerosing mesenteritis can cause abdominal pain, vomiting, bloating, diarrhea and fever. But some people experience no signs and symptoms and may never need treatment. […] Symptoms of sclerosing mesenteritis include pain in your belly, vomiting, bloating, diarrhea and fever. Sometimes people don’t have any symptoms. […] In rare cases, scar tissue formed by sclerosing mesenteritis can block food from moving through your digestive tract. In this case, you may need surgery. […] If sclerosing mesenteritis advances to block the flow of food through your digestive system, you may need surgery to remove the blockage.

• #78 Sclerosing mesenteritis | Radiology Reference Article | Radiopaedia.org

  https://radiopaedia.org/articles/sclerosing-mesenteritis-1?lang=us

  Sclerosing mesenteritis, also known as mesenteric panniculitis or retractile mesenteritis, is an uncommon idiopathic disorder characterized by chronic non-specific inflammation involving the adipose tissue of the bowel mesentery. […] Clinical presentation can be variable with fever and abdominal pain common. Intestinal obstruction or ischemia, a mass, or diarrhea may also be present. Altered bowel habits and weight loss may be present in some cases. Occasionally, intermittent partial bowel obstruction is encountered. A firm left upper quadrant / central abdominal mass may be felt. In some situations sclerosing mesenteritis is asymptomatic. […] The disease is said to pass through three stages, although some authors believe these to be separate entities: mesenteric lipodystrophy: degeneration of mesenteric fat; mesenteric panniculitis: inflammatory reaction; retractile mesenteritis / sclerosing mesenteritis: fibrosis, which may be associated with distortion or lymphatic obstruction. […] The mainstay of treatment is supportive, as the disease is typically self-limiting. If severe or protracted, medical therapy with corticosteroids, cyclophosphamide or azathioprine can be contemplated. Mesenteric panniculitis cannot be completely resected and surgery is of no benefit.

• #79 Sclerosing mesenteritis

  https://www.mymlc.com/health-information/diseases-and-conditions/s/sclerosing-mesenteritis/

  Sclerosing mesenteritis can cause abdominal pain, vomiting, bloating, diarrhea and fever. But some people experience no signs and symptoms and may never need treatment. […] Symptoms of sclerosing mesenteritis include pain in your belly, vomiting, bloating, diarrhea and fever. Sometimes people don’t have any symptoms. […] In rare cases, scar tissue formed by sclerosing mesenteritis can block food from moving through your digestive tract. In this case, you may need surgery. […] If sclerosing mesenteritis advances to block the flow of food through your digestive system, you may need surgery to remove the blockage.

• #80 Sclerosing Mesenteritis: Definition, Types & Treatment

  https://my.clevelandclinic.org/health/diseases/15284-sclerosing-mesenteritis

  Sclerosing mesenteritis is a chronic inflammatory condition that affects your mesentery, which is part of your peritoneum. It causes fibrosis (scarring) of the tissues. You may have symptoms of abdominal pain and swelling. […] The most common symptoms people report are abdominal pain and bloating. Severe inflammation may trigger diarrhea or fever. You may be able to feel a palpable mass when you touch your abdomen. In rare cases, a mass may obstruct your small intestine, causing additional symptoms of nausea, vomiting and weight loss. […] For most people, the prognosis (outlook) is good, but it can vary from person to person. Most people have mild to moderate symptoms, if any, but occasionally, it manifests as a more aggressive condition. It can last for a couple of days or as long as 10 years. It often goes away on its own, or with medications, but sometimes it doesn’t. It may take some trial and error to find the treatment that works best for you.

• #81 Frontiers | Sclerosing Mesenteritis, a Rare Cause of Mesenteric Mass in a Young Adult: A Case Report

  https://www.frontiersin.org/journals/surgery/articles/10.3389/fsurg.2021.722312/full

  Sclerosing mesenteritis (SM) is a rare fibroinflammatory disorder that involves mesenteric adipose tissue, more frequently localized in the small intestine, with an insidious clinical presentation having symptoms related to mass effect, usually resulting in bowel obstruction, mesenteric ischemia, as well as rapid weight loss. […] SM has an insidious clinical presentation with non-specific symptoms related to mass effect, usually resulting in bowel obstruction, mesenteric ischemia, as well as rapid weight loss. […] Symptoms are highly non-specific and include: abdominal pain, weight loss, presence of palpable mass, as shown by our patient, as well as fever, nausea and vomiting. […] Our patient experienced non-specific symptoms only, with only a few months of mesogastric pain and a 30 Kg weight loss in 1 year. […] The prognosis of SM is generally excellent, with the painful symptoms subsiding and the mass reducing in size in most patients.

• #82 Sclerosing Mesenteritis: Definition, Types & Treatment

  https://my.clevelandclinic.org/health/diseases/15284-sclerosing-mesenteritis

  Sclerosing mesenteritis is a chronic inflammatory condition that affects your mesentery, which is part of your peritoneum. It causes fibrosis (scarring) of the tissues. You may have symptoms of abdominal pain and swelling. […] The most common symptoms people report are abdominal pain and bloating. Severe inflammation may trigger diarrhea or fever. You may be able to feel a palpable mass when you touch your abdomen. In rare cases, a mass may obstruct your small intestine, causing additional symptoms of nausea, vomiting and weight loss. […] For most people, the prognosis (outlook) is good, but it can vary from person to person. Most people have mild to moderate symptoms, if any, but occasionally, it manifests as a more aggressive condition. It can last for a couple of days or as long as 10 years. It often goes away on its own, or with medications, but sometimes it doesn’t. It may take some trial and error to find the treatment that works best for you.

• #83 Sclerosing mesenteritis:an uncommon cause of chronic abdominal pain – MedCrave online

  https://medcraveonline.com/GHOA/sclerosing-mesenteritisan-uncommon-cause-of-chronic-abdominal-pain.html

  Majority of the patients have elevated C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR). […] The usual CT scan findings are mesenteric lymphadenopathy, fat sparing the mesenteric vessels also known are fat sparing sign, hazy mesenteric fat and separation of mesenteric vessels, increased thickness of the involved mesentery, and well or poorly defined mesenteric mass, pseudo capsule (soft-tissue surrounding the inflamed mass). […] Our patient had surgery for repair of the hernia but not all the affected mesenteries were removed. […] Several months after the diagnosis, he had a comfortable life with on and off mild abdominal pain which was resolved by ibuprofen. […] Finally, SM is a rare care of chronic abdominal pain. Though most of the cases are benign like ours, they can be associated with underlying malignancy which need to be ruled out.

• #84 A Clinical Review of Mesenteric Panniculitis – Gastroenterology & Hepatology

  https://www.gastroenterologyandhepatology.net/archives/april-2023/a-clinical-review-of-mesenteric-panniculitis/

  Although MP usually presents with a benign disease course, complications can occur because of the mass effect on adjacent structures causing bowel, lymphatic, or vascular obstruction. A large series of patients with MP (n=92) found that 28% presented with small bowel obstruction, 14% had chylous ascites, and 3% had superior mesenteric vein thrombosis. Over a 21-month follow-up period, there were 18 deaths, with 17% occurring from complications attributable to MP or its treatment. Although the overall prognosis of MP is good, this study found that MP was associated with significant morbidity in nearly 20% of patients. […] Also, MP has been proposed to be a progressive inflammatory process, starting from mesenteric lipodystrophy to retractile mesenteritis, triggered by a wide variety of stimuli, such as thermal or chemical injuries, vasculitis, avitaminosis, autoimmune disease, pancreatitis, bile or urine leakage, hypersensitivity reactions, and even bacterial infections. However, there is scarce evidence to demonstrate histologic progression of the disease.

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