Materiały źródłowe

• #1 Salivary Gland Cancer Treatment – NCI

  https://www.cancer.gov/types/head-and-neck/patient/adult/salivary-gland-treatment-pdq

  Salivary gland cancer is a rare disease in which malignant (cancer) cells form in the tissues of the salivary glands. […] There are different types of treatment for patients with salivary gland cancer. […] Patients with salivary gland cancer should have their treatment planned by a team of health care providers who are experts in treating head and neck cancer. […] The following types of treatment are used: Surgery, Radiation therapy, Chemotherapy. […] Surgery (removing the cancer in an operation) is a common treatment for salivary gland cancer. […] After the doctor removes all the cancer that can be seen at the time of the surgery, some patients may be given radiation therapy after surgery to kill any cancer that are left. Treatment given after the surgery, to lower the risk that the cancer will come back, is called adjuvant therapy.

• #2 Treating Salivary Gland Cancer | How is Salivary Cancer Treated? | American Cancer Society

  https://www.cancer.org/cancer/types/salivary-gland-cancer/treating.html

  If you’ve been diagnosed with salivary gland cancer, your cancer care team will discuss your treatment options with you. It’s important to weigh the benefits of each treatment option against the possible risks and side effects. […] Common treatment options for salivary gland cancer include: Surgery for Salivary Gland Cancer, Radiation Therapy for Salivary Gland Cancer, Chemotherapy for Salivary Gland Cancer, Targeted Drug Therapy for Salivary Gland Cancer, Immunotherapy for Salivary Gland Cancer. […] Sometimes more than one type of treatment is used. Which treatment option(s) might be best for you depends on many factors, including the type, grade, and stage of the cancer; your overall health; the chances of curing the disease; the impact of the treatment on functions like speech, chewing, and swallowing; and your own personal preferences.

• #3 5 innovative treatments for salivary gland cancer | MD Anderson Cancer Center

  https://www.mdanderson.org/cancer-types/salivary-gland-cancer/salivary-gland-cancer-treatment.html

  Treatment plans for salivary gland cancer can change drastically based on the tumors exact location and subtype. The right treatment plan can greatly reduce the chance of the cancer returning and help maintain your quality of life, including your ability to speak, swallow and hear. […] At MD Anderson you will get care from a team of salivary gland cancer experts, including a surgeon, radiation oncologist and medical oncologist. They will work together closely to discuss your case and develop a treatment plan tailored to you. […] Treatments can include many cutting-edge interventions, such as proton therapy, targeted therapy and advanced robotic surgeries. […] Surgery is the primary treatment for most salivary gland cancers. […] For salivary gland cancer, radiation therapy is typically used after surgery to kill any remaining cancer cells. It is also used when surgery isn’t possible.

• #4 Treating Salivary Gland Cancer | How is Salivary Cancer Treated? | American Cancer Society

  https://www.cancer.org/cancer/types/salivary-gland-cancer/treating.html

  If you’ve been diagnosed with salivary gland cancer, your cancer care team will discuss your treatment options with you. It’s important to weigh the benefits of each treatment option against the possible risks and side effects. […] Common treatment options for salivary gland cancer include: Surgery for Salivary Gland Cancer, Radiation Therapy for Salivary Gland Cancer, Chemotherapy for Salivary Gland Cancer, Targeted Drug Therapy for Salivary Gland Cancer, Immunotherapy for Salivary Gland Cancer. […] Sometimes more than one type of treatment is used. Which treatment option(s) might be best for you depends on many factors, including the type, grade, and stage of the cancer; your overall health; the chances of curing the disease; the impact of the treatment on functions like speech, chewing, and swallowing; and your own personal preferences.

• #5 Salivary gland tumors – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/salivary-gland-cancer/diagnosis-treatment/drc-20354155

  Treatment for salivary gland tumors usually involves surgery to remove the tumor. People with salivary gland cancers may need additional treatments. These additional treatments can include radiation therapy, chemotherapy, targeted therapy or immunotherapy. […] Surgery for salivary gland tumors may include: […] Removing part of the affected salivary gland. If your tumor is small and located in an easy-to-access spot, your surgeon may remove the tumor and a small portion of healthy tissue around it. […] Removing the entire salivary gland. If you have a larger tumor, your surgeon may recommend removing the entire salivary gland. If your tumor extends into nearby structures, they also may be removed. Nearby structures may include the facial nerves, the ducts that connect the salivary glands, facial bones and skin.

• #6 Salivary Gland Cancer Treatment – NCI

  https://www.cancer.gov/types/head-and-neck/patient/adult/salivary-gland-treatment-pdq

  Salivary gland cancer is a rare disease in which malignant (cancer) cells form in the tissues of the salivary glands. […] There are different types of treatment for patients with salivary gland cancer. […] Patients with salivary gland cancer should have their treatment planned by a team of health care providers who are experts in treating head and neck cancer. […] The following types of treatment are used: Surgery, Radiation therapy, Chemotherapy. […] Surgery (removing the cancer in an operation) is a common treatment for salivary gland cancer. […] After the doctor removes all the cancer that can be seen at the time of the surgery, some patients may be given radiation therapy after surgery to kill any cancer that are left. Treatment given after the surgery, to lower the risk that the cancer will come back, is called adjuvant therapy.

• #7 Management of salivary gland carcinomas – a review

  https://pmc.ncbi.nlm.nih.gov/articles/PMC5354805/

  Complete surgical resection, with adequate free margins, is currently the mainstay treatment for SGCs. […] Postoperative radiotherapy (PORT) can be used as an adjuvant therapy in patients with high-risk factors. […] In addition, very few clinical trials were designed to investigate the efficacy of novel treatment strategies. […] In summary, surgery predominates the treatment for SGCs, and PORT was recommended in patients with adverse prognostic factors, such as T3 or T4 tumors, close or incomplete resection margins, high grade, perineural or vascular invasion, and positive lymph nodes. […] For patients with inoperable disease, those who refuse surgery or those who have an unresectable tumor, primary RT should be considered. […] Chemotherapy as palliative treatment to deal with the patients with recurrent and/or metastatic disease, which has been proven to be of limited effect, and no chemotherapy regimen has been the effort to prolong or improve OS or DFS in these tumors.

• #8 Salivary gland tumors – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/salivary-gland-cancer/diagnosis-treatment/drc-20354155

  Treatment for salivary gland tumors usually involves surgery to remove the tumor. People with salivary gland cancers may need additional treatments. These additional treatments can include radiation therapy, chemotherapy, targeted therapy or immunotherapy. […] Surgery for salivary gland tumors may include: […] Removing part of the affected salivary gland. If your tumor is small and located in an easy-to-access spot, your surgeon may remove the tumor and a small portion of healthy tissue around it. […] Removing the entire salivary gland. If you have a larger tumor, your surgeon may recommend removing the entire salivary gland. If your tumor extends into nearby structures, they also may be removed. Nearby structures may include the facial nerves, the ducts that connect the salivary glands, facial bones and skin.

• #9 Salivary Gland Neoplasms Treatment & Management: Medical Therapy, Surgical Therapy, Intraoperative Details

  https://emedicine.medscape.com/article/852373-treatment

  Surgery is the primary treatment of malignant tumors of the salivary glands. This is often combined with postoperative radiation therapy, depending on the specific tumor characteristics and stage. The extent of surgery is based on the size of the tumor, local extension, and neck metastases. The facial nerve is spared unless it is directly involved. Postoperative adjuvant radiation therapy is recommended for high-grade malignancies and high-stage cancers. […] […] Carefully planned and executed surgical excision is the primary treatment for all primary salivary gland tumors. The principles of surgery vary with the site of origin and are discussed as such. […] […] For group 2 tumors, a wider resection of the submandibular triangle is required for clear margins. Sacrifice nerves only if they are directly involved with a tumor. Frozen-section sampling of the epineurium of cranial nerves near the tumor mass may be performed, with the results directing further excision. Perform neck dissection for clinically positive disease. Postoperative radiation therapy is given. […]

• #10 Salivary gland tumors – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/salivary-gland-cancer/diagnosis-treatment/drc-20354155

  Treatment for salivary gland tumors usually involves surgery to remove the tumor. People with salivary gland cancers may need additional treatments. These additional treatments can include radiation therapy, chemotherapy, targeted therapy or immunotherapy. […] Surgery for salivary gland tumors may include: […] Removing part of the affected salivary gland. If your tumor is small and located in an easy-to-access spot, your surgeon may remove the tumor and a small portion of healthy tissue around it. […] Removing the entire salivary gland. If you have a larger tumor, your surgeon may recommend removing the entire salivary gland. If your tumor extends into nearby structures, they also may be removed. Nearby structures may include the facial nerves, the ducts that connect the salivary glands, facial bones and skin.

• #11 Salivary gland tumors – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/salivary-gland-cancer/diagnosis-treatment/drc-20354155

  Treatment for salivary gland tumors usually involves surgery to remove the tumor. People with salivary gland cancers may need additional treatments. These additional treatments can include radiation therapy, chemotherapy, targeted therapy or immunotherapy. […] Surgery for salivary gland tumors may include: […] Removing part of the affected salivary gland. If your tumor is small and located in an easy-to-access spot, your surgeon may remove the tumor and a small portion of healthy tissue around it. […] Removing the entire salivary gland. If you have a larger tumor, your surgeon may recommend removing the entire salivary gland. If your tumor extends into nearby structures, they also may be removed. Nearby structures may include the facial nerves, the ducts that connect the salivary glands, facial bones and skin.

• #12 Treatment options | Salivary gland cancer | Cancer Research UK

  https://www.cancerresearchuk.org/about-cancer/salivary-gland-cancer/treatment/decisions

  The main treatments for salivary gland cancer are surgery, radiotherapy and chemotherapy. You might have one or more of these treatments. […] Surgery alone will cure some salivary gland cancers. For other cancers, a combination of surgery and radiotherapy will work better. […] Doctors might use chemotherapy to control more advanced cancers or as part of a clinical trial. Or you might have a targeted cancer drug as part of a clinical trial for advanced salivary gland cancer. […] Surgery is the most common treatment for salivary gland cancer. It works very well for early stage cancers. […] Your surgeon does this to help to find out where the cancer is (the stage) and to get rid of any remaining cancer cells. This reduces the risk of the cancer coming back in the lymph nodes. […] Radiotherapy uses high energy rays to kill cancer cells. Your doctor may recommend that you have radiotherapy after surgery. This helps to kill any cancer cells that might have been left behind and reduces the risk of the cancer coming back.

• #13 Surgery for Salivary Gland Cancer | Head & Neck Cancer | Cancer Council NSW

  https://www.cancercouncil.com.au/head-and-neck-cancer/treatment/surgery/surgery-for-salivary-gland-cancer/

  Most salivary gland tumours affect one of the parotid glands, which sit in front of the ears. Surgery to remove part or all of a parotid gland is called a parotidectomy. […] If the cancer affects a gland under the lower jaw (submandibular gland) or under the tongue (sublingual gland), the gland will be removed, along with some surrounding tissue. Nerves controlling the tongue and lower part of the face may be damaged, which may cause some loss of function (e.g. how you speak, eat or close your mouth).

• #14 Salivary Gland Cancer Treatment | Memorial Sloan Kettering Cancer Center

  https://www.mskcc.org/cancer-care/types/salivary-gland/salivary-gland-cancer-treatment

  We offer our patients unparalleled skill in salivary gland surgery. Our surgeons have extensive experience in removing tumors of the parotid glands, submandibular glands, and other salivary glands. This includes highly complex or large tumors. […] Our surgical care teams prioritize preserving the facial nerve during surgery. They use meticulous surgical techniques and the most-advanced facial nerve monitoring technology. It helps them locate, work around, and protect the facial nerve whenever possible. […] We deliver radiation therapy using the most-modern and most-precise methods available. We tailor them just for salivary gland tumors. […] Our patients have access to exciting new drug therapies through our program of clinical trials. […] Our rehabilitation experts and speech pathologists design individualized treatment plans. They can help you manage problems with your speech, voice, swallowing, and other side effects of salivary gland tumors and their treatment.

• #15 Salivary gland tumors | Treatment | UK Healthcare

  https://ukhealthcare.uky.edu/markey-cancer-center/cancer-types/head-neck-cancer/salivary-gland-tumors/treatment

  Outstanding cancer care requires an unparalleled team. Our specialists in medical oncology, chemotherapy, radiation medicine, pathology and surgery all work and consult together to deliver you the most effective treatments. […] Our head and neck surgeons are experts at complex, highly technical surgical techniques to remove salivary gland tumors. We use advanced monitoring to protect facial nerves during surgery. […] We treat most salivary gland tumors with surgery first. Salivary gland tumors are rare, but our surgeons are experienced and perform more than 100 of these delicate surgeries each year. […] Our doctors use advanced facial nerve monitoring during surgery. This allows us to preserve as much nerve function as possible. […] We often use radiation therapy after surgery to kill any remaining cancer cells and prevent cancer from returning. Radiation uses high-energy rays to destroy cancer.

• #16 Salivary Gland Cancer Treatment (PDQ®) – NCI

  https://www.cancer.gov/types/head-and-neck/hp/adult/salivary-gland-treatment-pdq

  The minimum therapy for patients with low-grade malignancies of the superficial portion of the parotid gland is a superficial parotidectomy. For all other lesions, a total parotidectomy is often indicated. The facial nerve or its branches should be resected if involved by tumor; repair can be done simultaneously. Evidence suggests that postoperative radiation therapy augments surgical resection, particularly for the high-grade neoplasms, when margins are close or involved, when tumors are large, or when histological evidence of lymph node metastases is present. […] Clinical trials in the United States and England indicated that fast neutron-beam radiation therapy improves disease-free survival and overall survival in patients with unresectable tumors or for patients with recurrent neoplasms.

• #17 Salivary gland tumors – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/salivary-gland-cancer/diagnosis-treatment/drc-20354155

  Treatment for salivary gland tumors usually involves surgery to remove the tumor. People with salivary gland cancers may need additional treatments. These additional treatments can include radiation therapy, chemotherapy, targeted therapy or immunotherapy. […] Surgery for salivary gland tumors may include: […] Removing part of the affected salivary gland. If your tumor is small and located in an easy-to-access spot, your surgeon may remove the tumor and a small portion of healthy tissue around it. […] Removing the entire salivary gland. If you have a larger tumor, your surgeon may recommend removing the entire salivary gland. If your tumor extends into nearby structures, they also may be removed. Nearby structures may include the facial nerves, the ducts that connect the salivary glands, facial bones and skin.

• #18 Salivary Gland Cancer | Condition | UT Southwestern Medical Center

  https://utswmed.org/conditions-treatments/salivary-gland-cancer/

  Radiation therapy: Our doctors use radiation, treatment with high-energy waves such as X-rays or gamma rays, to treat salivary gland cancer. Radiation therapy can destroy cancer cells left after surgery, and it can also treat inoperable tumors. […] Chemotherapy: Anticancer medications work to destroy cancer cells and prevent them from spreading. Although we rarely use chemotherapy to treat salivary gland cancer, it might be necessary to treat cancer that has spread or cannot be removed through surgery or radiation therapy. […] Chemoradiation: Chemotherapy given at the same time as radiation therapy is known as chemoradiation. We might recommend chemoradiation after surgery to remove tumors or to help prevent them from coming back. […] Reconstructive surgery: Patients with advanced salivary gland cancer might need reconstruction after cancer surgery, to replace tissue or nerves if they were removed. Our plastic surgery and ENT experts work together to restore swallowing and other oral functions for a more natural appearance of the throat and neck.

• #19 Salivary gland tumors – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/salivary-gland-cancer/diagnosis-treatment/drc-20354155

  Removing lymph nodes in your neck. If your salivary gland tumor is cancerous, there may be a risk that the cancer has spread to the lymph nodes. Your surgeon may recommend removing some lymph nodes from your neck and testing them for cancer. […] Reconstructive surgery. After the tumor is removed, your surgeon may recommend reconstructive surgery to repair the area. If bone, skin or nerves are removed during your surgery, these may need to be repaired or replaced using reconstructive surgery. […] If you’re diagnosed with salivary gland cancer, your healthcare team may recommend radiation therapy. Radiation therapy treats cancer with powerful energy beams. The energy can come from X-rays, protons or other sources. For salivary gland cancer, radiation therapy is most often done with a procedure called external beam radiation.

• #20 Salivary Gland Cancer Treatment – NCI

  https://www.cancer.gov/types/head-and-neck/patient/adult/salivary-gland-treatment-pdq

  Radiation therapy is a cancer treatment that uses high-energy x-rays or other types of radiation to kill cancer cells or keep them from growing. […] External radiation therapy is used to treat salivary gland cancer and may also be used as palliative therapy to relieve symptoms and improve quality of life. […] Chemotherapy is a cancer treatment that uses drugs to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. […] New types of treatment are being tested in clinical trials. […] Treatment for salivary gland cancer may cause side effects. […] Patients may want to think about taking part in a clinical trial. […] Treatment for stage I salivary gland cancer depends on whether the cancer is low-grade (slow growing) or high-grade (fast growing).

• #21 Treatment options | Salivary gland cancer | Cancer Research UK

  https://www.cancerresearchuk.org/about-cancer/salivary-gland-cancer/treatment/decisions

  The main treatments for salivary gland cancer are surgery, radiotherapy and chemotherapy. You might have one or more of these treatments. […] Surgery alone will cure some salivary gland cancers. For other cancers, a combination of surgery and radiotherapy will work better. […] Doctors might use chemotherapy to control more advanced cancers or as part of a clinical trial. Or you might have a targeted cancer drug as part of a clinical trial for advanced salivary gland cancer. […] Surgery is the most common treatment for salivary gland cancer. It works very well for early stage cancers. […] Your surgeon does this to help to find out where the cancer is (the stage) and to get rid of any remaining cancer cells. This reduces the risk of the cancer coming back in the lymph nodes. […] Radiotherapy uses high energy rays to kill cancer cells. Your doctor may recommend that you have radiotherapy after surgery. This helps to kill any cancer cells that might have been left behind and reduces the risk of the cancer coming back.

• #22 Salivary Gland Cancer Treatment by Stage | Salivary Cancer Treatment | American Cancer Society

  https://www.cancer.org/cancer/types/salivary-gland-cancer/treating/by-stage.html

  The treatment options for salivary gland cancer depend largely on the type and stage (extent) of the cancer. But other factors, such as the grade of the cancer (how likely it is to grow and spread); and a persons overall health, can also be important. […] Since salivary gland cancers are rare and can be hard to treat, clinical trials might be a good option to think about. […] If you have stage I salivary gland cancer, your doctors will probably recommend surgery to remove the cancer and part or all of the salivary gland. […] Radiation therapy might be advised after surgery if you have an intermediate- or high-grade cancer or an adenoid cystic carcinoma, if the cancer could not be removed completely, if the edges of the removed area have cancer cells (a sign that some cancer might have been left behind), or if the cancer is invading (growing into) nearby nerves.

• #23 Management of salivary gland carcinomas – a review

  https://pmc.ncbi.nlm.nih.gov/articles/PMC5354805/

  Complete surgical resection, with adequate free margins, is currently the mainstay treatment for SGCs. […] Postoperative radiotherapy (PORT) can be used as an adjuvant therapy in patients with high-risk factors. […] In addition, very few clinical trials were designed to investigate the efficacy of novel treatment strategies. […] In summary, surgery predominates the treatment for SGCs, and PORT was recommended in patients with adverse prognostic factors, such as T3 or T4 tumors, close or incomplete resection margins, high grade, perineural or vascular invasion, and positive lymph nodes. […] For patients with inoperable disease, those who refuse surgery or those who have an unresectable tumor, primary RT should be considered. […] Chemotherapy as palliative treatment to deal with the patients with recurrent and/or metastatic disease, which has been proven to be of limited effect, and no chemotherapy regimen has been the effort to prolong or improve OS or DFS in these tumors.

• #24 Salivary Gland Cancer Treatment (PDQ®) – PDQ Cancer Information Summaries – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK65952/

  Fast neutron-beam radiation therapy or accelerated hyperfractionated photon-beam schedules have been reported to be more effective than conventional x-ray therapy in the treatment of patients with inoperable, unresectable, or recurrent malignant salivary gland tumors. […] Patients with localized high-grade salivary gland tumors that are confined to the gland in which they arise may be cured by radical surgery alone. […] Postoperative radiation therapy may improve local control and increase survival rates for patients with high-grade tumors, positive surgical margins, or perineural invasion. […] Fast neutron-beam radiation therapy is superior to conventional radiation therapy using x-rays and may be curative in selected patients with recurrent disease. […] Patients with inoperable, unresectable, or recurrent malignant salivary gland tumors treated with fast neutron-beam radiation therapy have better disease-free survival and overall survival than patients treated with conventional x-ray radiation therapy.

• #25 Salivary Gland Cancer Treatment by Stage | Salivary Cancer Treatment | American Cancer Society

  https://www.cancer.org/cancer/types/salivary-gland-cancer/treating/by-stage.html

  Radiation therapy may be given after surgery if your cancer is intermediate- or high-grade or an adenoid cystic carcinoma, if the cancer could not be removed completely, if the cancer is invading nearby blood vessels, lymph vessels, or nerves; if the removed lymph nodes have cancer; or if the edges of the removed tissue contain cancer cells. Chemotherapy might be given along with radiation in certain cases, but this combination treatment is still being studied. […] Radiation therapy might be an option as the main treatment if surgery would result in serious problems with eating, speech, or appearance, or for people who refuse surgery. […] Doctors generally recommend extensive surgery (removing the salivary gland containing the tumor, nearby tissues, and lymph nodes in your neck on the same side) if its possible.

• #26 Management of salivary gland carcinomas – a review

  https://pmc.ncbi.nlm.nih.gov/articles/PMC5354805/

  Complete surgical resection, with adequate free margins, is currently the mainstay treatment for SGCs. […] Postoperative radiotherapy (PORT) can be used as an adjuvant therapy in patients with high-risk factors. […] In addition, very few clinical trials were designed to investigate the efficacy of novel treatment strategies. […] In summary, surgery predominates the treatment for SGCs, and PORT was recommended in patients with adverse prognostic factors, such as T3 or T4 tumors, close or incomplete resection margins, high grade, perineural or vascular invasion, and positive lymph nodes. […] For patients with inoperable disease, those who refuse surgery or those who have an unresectable tumor, primary RT should be considered. […] Chemotherapy as palliative treatment to deal with the patients with recurrent and/or metastatic disease, which has been proven to be of limited effect, and no chemotherapy regimen has been the effort to prolong or improve OS or DFS in these tumors.

• #27 Salivary Gland Cancer: Symptoms, Causes & Treatment

  https://my.clevelandclinic.org/health/diseases/17965-salivary-gland-cancer

  Surgery is usually the best treatment option for tumors that can be safely removed. If a tumor is growing fast or if its spread to other parts of your body, your healthcare provider may recommend additional treatments. […] Treatments include: […] Surgery is the primary treatment for malignant salivary gland tumors. In addition to removing the tumor, your provider may remove your lymph nodes (lymphadenectomy) if they suspect the cancers spread there. After surgery, youll likely receive radiation therapy to kill any remaining cancer cells, so the cancer doesnt return. […] Radiation therapy uses a machine that directs radiation toward the part of your body with cancer cells, destroying them. Photon-beam and neutron beam radiation therapy are two types of radiation therapy used to treat salivary gland cancer. You may also receive radiation as a part of palliative care. Palliative care provides symptom relief and can improve your quality of life.

• #28 Salivary Gland Cancer Treatment – NCI

  https://www.cancer.gov/types/head-and-neck/patient/adult/salivary-gland-treatment-pdq

  Radiation therapy is a cancer treatment that uses high-energy x-rays or other types of radiation to kill cancer cells or keep them from growing. […] External radiation therapy is used to treat salivary gland cancer and may also be used as palliative therapy to relieve symptoms and improve quality of life. […] Chemotherapy is a cancer treatment that uses drugs to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. […] New types of treatment are being tested in clinical trials. […] Treatment for salivary gland cancer may cause side effects. […] Patients may want to think about taking part in a clinical trial. […] Treatment for stage I salivary gland cancer depends on whether the cancer is low-grade (slow growing) or high-grade (fast growing).

• #29 Salivary Gland Cancer Treatment (PDQ®) – NCI

  https://www.cancer.gov/types/head-and-neck/hp/adult/salivary-gland-treatment-pdq

  Fast neutron-beam radiation therapy or accelerated hyperfractionated photon-beam schedules have been reported to be more effective than conventional x-ray therapy in the treatment of patients with inoperable, unresectable, or recurrent malignant salivary gland tumors. […] Patients with inoperable, unresectable, or recurrent malignant salivary gland tumors treated with fast neutron-beam radiation therapy have better disease-free survival and overall survival than patients treated with conventional x-ray radiation therapy.

• #30 Salivary Gland Cancer Treatment (PDQ®) – PDQ Cancer Information Summaries – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK65952/

  Fast neutron-beam radiation therapy or accelerated hyperfractionated photon-beam schedules have been reported to be more effective than conventional x-ray therapy in the treatment of patients with inoperable, unresectable, or recurrent malignant salivary gland tumors. […] Patients with localized high-grade salivary gland tumors that are confined to the gland in which they arise may be cured by radical surgery alone. […] Postoperative radiation therapy may improve local control and increase survival rates for patients with high-grade tumors, positive surgical margins, or perineural invasion. […] Fast neutron-beam radiation therapy is superior to conventional radiation therapy using x-rays and may be curative in selected patients with recurrent disease. […] Patients with inoperable, unresectable, or recurrent malignant salivary gland tumors treated with fast neutron-beam radiation therapy have better disease-free survival and overall survival than patients treated with conventional x-ray radiation therapy.

• #31 Treatment for Salivary Gland Cancer | Fred Hutchinson Cancer Center

  https://www.fredhutch.org/en/diseases/salivary-gland-cancer/treatment.html

  When salivary gland tumors are detected early, the standard treatment is surgical resection, or removal. […] Neutron therapy is especially good at controlling salivary gland cancer at the tumor site and in the same region. […] Neutron therapy can be used to treat cancer in areas other than the salivary glands as well. […] Regular radiation therapy for cancer uses beams of electrons or photons (also called x-rays) to bombard cancer cells. […] Neutron therapy uses beams of neutrons to attack cancer cells. […] Our goal is to optimize the neutron beam to maximize damage to the tumor and minimize damage to any other tissue, says Laramore. […] An actual treatment session takes about 30 to 60 minutes, depending on how complicated the treatment delivery scheme is. […] The side effects from neutron therapy are similar to those from regular radiation therapy but may be more intense.

• #32 Treatment for Salivary Gland Cancer | Fred Hutchinson Cancer Center

  https://www.fredhutch.org/en/diseases/salivary-gland-cancer/treatment.html

  When salivary gland tumors are detected early, the standard treatment is surgical resection, or removal. […] Neutron therapy is especially good at controlling salivary gland cancer at the tumor site and in the same region. […] Neutron therapy can be used to treat cancer in areas other than the salivary glands as well. […] Regular radiation therapy for cancer uses beams of electrons or photons (also called x-rays) to bombard cancer cells. […] Neutron therapy uses beams of neutrons to attack cancer cells. […] Our goal is to optimize the neutron beam to maximize damage to the tumor and minimize damage to any other tissue, says Laramore. […] An actual treatment session takes about 30 to 60 minutes, depending on how complicated the treatment delivery scheme is. […] The side effects from neutron therapy are similar to those from regular radiation therapy but may be more intense.

• #33 Treatment for Salivary Gland Cancer | Fred Hutchinson Cancer Center

  https://www.fredhutch.org/en/diseases/salivary-gland-cancer/treatment.html

  When salivary gland tumors are detected early, the standard treatment is surgical resection, or removal. […] Neutron therapy is especially good at controlling salivary gland cancer at the tumor site and in the same region. […] Neutron therapy can be used to treat cancer in areas other than the salivary glands as well. […] Regular radiation therapy for cancer uses beams of electrons or photons (also called x-rays) to bombard cancer cells. […] Neutron therapy uses beams of neutrons to attack cancer cells. […] Our goal is to optimize the neutron beam to maximize damage to the tumor and minimize damage to any other tissue, says Laramore. […] An actual treatment session takes about 30 to 60 minutes, depending on how complicated the treatment delivery scheme is. […] The side effects from neutron therapy are similar to those from regular radiation therapy but may be more intense.

• #34 Salivary Gland Cancer: Symptoms, Causes & Treatment

  https://my.clevelandclinic.org/health/diseases/17965-salivary-gland-cancer

  Surgery is usually the best treatment option for tumors that can be safely removed. If a tumor is growing fast or if its spread to other parts of your body, your healthcare provider may recommend additional treatments. […] Treatments include: […] Surgery is the primary treatment for malignant salivary gland tumors. In addition to removing the tumor, your provider may remove your lymph nodes (lymphadenectomy) if they suspect the cancers spread there. After surgery, youll likely receive radiation therapy to kill any remaining cancer cells, so the cancer doesnt return. […] Radiation therapy uses a machine that directs radiation toward the part of your body with cancer cells, destroying them. Photon-beam and neutron beam radiation therapy are two types of radiation therapy used to treat salivary gland cancer. You may also receive radiation as a part of palliative care. Palliative care provides symptom relief and can improve your quality of life.

• #35 Salivary Gland Cancer Treatment – NCI

  https://www.cancer.gov/types/head-and-neck/patient/adult/salivary-gland-treatment-pdq

  Radiation therapy is a cancer treatment that uses high-energy x-rays or other types of radiation to kill cancer cells or keep them from growing. […] External radiation therapy is used to treat salivary gland cancer and may also be used as palliative therapy to relieve symptoms and improve quality of life. […] Chemotherapy is a cancer treatment that uses drugs to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. […] New types of treatment are being tested in clinical trials. […] Treatment for salivary gland cancer may cause side effects. […] Patients may want to think about taking part in a clinical trial. […] Treatment for stage I salivary gland cancer depends on whether the cancer is low-grade (slow growing) or high-grade (fast growing).

• #36 Salivary gland tumors – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/salivary-gland-cancer/diagnosis-treatment/drc-20354155

  Chemotherapy treats cancer with strong medicines. Chemotherapy isn’t currently used as a standard treatment for salivary gland cancer, but researchers are studying its use. […] Targeted therapy for cancer is a treatment that uses medicines that attack specific chemicals in the cancer cells. […] For salivary gland cancer, immunotherapy may be used on cancer that can’t be removed with surgery. It also may be used for advanced cancers that have spread to other parts of the body or cancer that has come back after treatment. […] Palliative care is a special type of healthcare that helps you feel better when you have a serious illness. If you have cancer, palliative care can help relieve pain and other symptoms.

• #37 Salivary Gland Cancer: Symptoms, Causes & Treatment

  https://my.clevelandclinic.org/health/diseases/17965-salivary-gland-cancer

  Chemotherapy uses drugs to destroy cancer cells. You may receive chemotherapy if your cancer has spread from your salivary glands to other tissues outside of your head and neck. […] Your healthcare provider may recommend that you participate in a clinical trial. A clinical trial is research that studies the safety and effectiveness of new treatments. […] Immunotherapy uses drugs to help your immune system identify cancer cells and fight them. Researchers are studying the role of a specific type of immunotherapy called checkpoint inhibitors in fighting metastasized cancer. […] Targeted therapy uses drugs that target weaknesses in a cancer cells genetic code (DNA) to destroy the cancer or stop it from growing. Researchers are studying the effectiveness of targeted therapies in people with adenoid cystic carcinomas that have metastasized.

• #38 Treatment options | Salivary gland cancer | Cancer Research UK

  https://www.cancerresearchuk.org/about-cancer/salivary-gland-cancer/treatment/decisions

  You might also have radiotherapy as the main treatment if it isnt possible to remove your cancer in an operation. […] Chemotherapy uses anti cancer (cytotoxic) drugs to disrupt and kill cancer cells. Chemotherapy doesnt work as well as surgery and radiotherapy for salivary gland cancer. So this isn’t a common treatment. […] You may have chemotherapy: to treat advanced cancers, or those that have spread to other parts of your body; if your cancer has come back after surgery and radiotherapy; as part of a clinical trial. […] Your doctor might recommend surgery to remove all or part of the cancer and help relieve symptoms if your tumour is large. They may also suggest radiotherapy and chemotherapy. […] You might have it if your cancer is advanced, or if you can’t have surgery or radiotherapy.

• #39 Salivary gland cancer | Macmillan Cancer Support

  https://www.macmillan.org.uk/cancer-information-and-support/head-and-neck-cancer/salivary-gland-cancer

  You may have radiotherapy after surgery to reduce the risk of the cancer coming back. […] Chemotherapy uses anti-cancer (cytotoxic) drugs to destroy cancer cells. It may be used to treat the symptoms of salivary gland cancer that has spread. […] You might have chemotherapy if you have advanced salivary gland cancer, and you cannot have surgery or radiotherapy.

• #40 Treatment options | Salivary gland cancer | Cancer Research UK

  https://www.cancerresearchuk.org/about-cancer/salivary-gland-cancer/treatment/decisions

  You might also have radiotherapy as the main treatment if it isnt possible to remove your cancer in an operation. […] Chemotherapy uses anti cancer (cytotoxic) drugs to disrupt and kill cancer cells. Chemotherapy doesnt work as well as surgery and radiotherapy for salivary gland cancer. So this isn’t a common treatment. […] You may have chemotherapy: to treat advanced cancers, or those that have spread to other parts of your body; if your cancer has come back after surgery and radiotherapy; as part of a clinical trial. […] Your doctor might recommend surgery to remove all or part of the cancer and help relieve symptoms if your tumour is large. They may also suggest radiotherapy and chemotherapy. […] You might have it if your cancer is advanced, or if you can’t have surgery or radiotherapy.

• #41 Systemic therapy for recurrent or metastatic salivary gland malignancies | Cancers of the Head & Neck | Full Text

  https://cancersheadneck.biomedcentral.com/articles/10.1186/s41199-016-0011-z

  Salivary gland carcinomas are notoriously resistant to therapy and no standard of care exists. […] Every effort should be made to treat salivary gland malignancies under a clinical protocol and/or at a large multidisciplinary practice with clinicians experienced in treating these malignancies. […] Surgical resection is the cornerstone of treatment for salivary gland malignancies. Radiotherapy is often employed as adjuvant therapy for tumors deemed to be at high risk of recurrence or as definitive treatment when surgical resection is not feasible. […] The primary use of chemotherapy or systemic therapy is for patients with recurrent or metastatic disease for whom surgery or radiotherapy is not possible. […] The potential benefit of adding platinum chemotherapy to adjuvant radiotherapy for high-risk salivary cancer is currently under investigation in RTOG 1008 (NCT01220583), and the results of this randomized trial will hopefully inform future management.

• #42

  https://link.springer.com/article/10.1007/s12254-020-00614-z

  Active agents that were tested mainly in phase II studies include cisplatin, mitoxantron, epirubicin and vinorelbine. […] Combination therapy with cisplatin, doxorubicin and cyclophosphamide (CAP) provided overall response rates (ORR) between 18-33% in a total of 4 studies. […] A doublet therapy consisting of cisplatin and an anthracycline leads to ORR of roughly 25%. […] Given the fact that chemotherapy has only limited efficacy in ACC, approaches targeting molecular targets were investigated. […] Recently, lenvatinib showed modest activity in a phase II trial of 33 previously treated patients with ACC. […] In the absence of driver mutations, chemotherapy can be offered to these patients. […] Overexpression or amplification of human epidermal growth factor receptor 2 (HER2) is reported in up to 30% of MEC, in 40% of SDC and in 20% of AC NOS.

• #43 Salivary Gland Neoplasms Treatment & Management: Medical Therapy, Surgical Therapy, Intraoperative Details

  https://emedicine.medscape.com/article/852373-treatment

  Medical Therapy […] In general, salivary gland neoplasms respond poorly to chemotherapy, and adjuvant chemotherapy is currently indicated only for palliation. Doxorubicin- and platinum-based agents are most commonly used with the platinum-based agents that induce apoptosis versus the doxorubicin-based drugs that promote cell arrest. Platinum-based agents, in combination with mitoxantrone or vinorelbine, are also effective in controlling recurrent salivary gland malignancy. A new form of 5-fluorouracil called fluoropyrimidine that has increased activity against malignant cells and while having fewer gastrointestinal side effects has shown to be efficacious against malignant salivary cancers and to potentiate the effects of radiotherapy by increasing apoptosis. […] […] Radiotherapy is rarely the definitive treatment modality for salivary gland neoplasms, being used alone usually for tumors that are considered nonresectable. More studies have quantified the use of radiotherapy in the postoperative setting. The use of radiation in T1 and T2 parotid gland tumors found that 5-year disease-free survival increased from 70% to 92% with postoperative radiation. A second study investigated postresection radiotherapy for carcinoma ex pleomorphic adenoma and found a 26% improvement in 5-year local control (from 49% to 75%). […]

• #44

  https://link.springer.com/article/10.1007/s12254-020-00614-z

  Active agents that were tested mainly in phase II studies include cisplatin, mitoxantron, epirubicin and vinorelbine. […] Combination therapy with cisplatin, doxorubicin and cyclophosphamide (CAP) provided overall response rates (ORR) between 18-33% in a total of 4 studies. […] A doublet therapy consisting of cisplatin and an anthracycline leads to ORR of roughly 25%. […] Given the fact that chemotherapy has only limited efficacy in ACC, approaches targeting molecular targets were investigated. […] Recently, lenvatinib showed modest activity in a phase II trial of 33 previously treated patients with ACC. […] In the absence of driver mutations, chemotherapy can be offered to these patients. […] Overexpression or amplification of human epidermal growth factor receptor 2 (HER2) is reported in up to 30% of MEC, in 40% of SDC and in 20% of AC NOS.

• #45 Systemic therapy for recurrent or metastatic salivary gland malignancies | Cancers of the Head & Neck | Full Text

  https://cancersheadneck.biomedcentral.com/articles/10.1186/s41199-016-0011-z

  The use of hormone therapy and anti-HER2 therapy for salivary duct carcinoma or AR+/HER2+ adenocarcinoma is a treatment approach that should continue to be refined and investigated. […] Given the clinical rarity and nuances of each salivary cancer subtype and the changing academic landscape with a steadily increasing number of therapeutic options and clinical trials, management by an experienced head and neck medical oncologist at a tertiary referral center or academic institution is preferred if possible.

• #46

  https://link.springer.com/article/10.1007/s12254-020-00614-z

  A very recent phase II study included 57 SDC patients with HER2 overexpression. The combination treatment of trastuzumab and docetaxel showed promising results with an ORR of 70.2% and mOS 39.7 months. […] AR expression is a frequent event in SDC and AC NOS, with rates of up to 90%. Androgen deprivation therapy (ADT) is an option for those patients with AR expression SGC. […] Both compounds are well tolerated and no discontinuation due to adverse events occurred.

• #47 Salivary Gland Cancer Treatment by Stage | Salivary Cancer Treatment | American Cancer Society

  https://www.cancer.org/cancer/types/salivary-gland-cancer/treating/by-stage.html

  Radiation therapy may be given after surgery if your cancer is intermediate- or high-grade or an adenoid cystic carcinoma, if the cancer could not be removed completely, if the cancer is invading nearby blood vessels, lymph vessels, or nerves; if the removed lymph nodes have cancer; or if the edges of the removed tissue contain cancer cells. Chemotherapy might be given along with radiation in certain cases, but this combination treatment is still being studied. […] Radiation therapy might be an option as the main treatment if surgery would result in serious problems with eating, speech, or appearance, or for people who refuse surgery. […] Doctors generally recommend extensive surgery (removing the salivary gland containing the tumor, nearby tissues, and lymph nodes in your neck on the same side) if its possible.

• #48 Systemic therapy for recurrent or metastatic salivary gland malignancies | Cancers of the Head & Neck | Full Text

  https://cancersheadneck.biomedcentral.com/articles/10.1186/s41199-016-0011-z

  Salivary gland carcinomas are notoriously resistant to therapy and no standard of care exists. […] Every effort should be made to treat salivary gland malignancies under a clinical protocol and/or at a large multidisciplinary practice with clinicians experienced in treating these malignancies. […] Surgical resection is the cornerstone of treatment for salivary gland malignancies. Radiotherapy is often employed as adjuvant therapy for tumors deemed to be at high risk of recurrence or as definitive treatment when surgical resection is not feasible. […] The primary use of chemotherapy or systemic therapy is for patients with recurrent or metastatic disease for whom surgery or radiotherapy is not possible. […] The potential benefit of adding platinum chemotherapy to adjuvant radiotherapy for high-risk salivary cancer is currently under investigation in RTOG 1008 (NCT01220583), and the results of this randomized trial will hopefully inform future management.

• #49

  https://link.springer.com/article/10.1007/s12254-020-00614-z

  Salivary gland cancers (SGC) are a rare and heterogeneous group of malignancies. For locally advanced or metastatic disease, chemotherapy has been the mainstay of therapy. […] However, due to advances in the understanding of tumor biology and molecular testing, drugable genetic changes like androgen receptor (AR) status, HER2/neu overexpression and neurotrophic tyrosine receptor kinase (NTRK) gene fusion have evolved as potential therapy targets in subsets of SGC. Consequently therapy with androgen receptor blockade (ARB) can be offered to patients with AR expressing tumors. Anti-HER2 therapy with trastzumab is an option for the treatment of tumors with overexpression of HER2/neu and finally NTRAK inhibitors can be used for tumors harboring a NTRK gene fusion. […] The aim of this review is to recapitulate treatment options for ACC and non-ACC, especially focusing on targeted therapies which are already available for subsets of SGCs.

• #50 Targeted cancer drugs for salivary gland cancer | Cancer Research UK

  https://www.cancerresearchuk.org/about-cancer/salivary-gland-cancer/treatment/targeted

  Targeted drugs work by targeting the differences in cancer cells that help them to grow and survive. They are a treatment for salivary gland cancer when the cancer has spread or other treatments stop working. […] You might have one of these treatments if your salivary gland cancer has a gene change (mutation) or a certain protein that helps the cancer grow. This may be as part of a clinical trial. […] Targeted drugs can help some people with advanced salivary gland cancer. Although these treatments cant cure the cancer, they may help to control it for a time and help some people to live longer. […] If your cancer has an NTRK gene change then you might have the following targeted cancer drugs: larotrectinib (Vitrakvi) and entrectinib (Rozlytrek). […] Certain drugs can target HER2 positive cancers. If you have HER2 positive salivary gland cancer that is advanced or has come back after previous treatment you might have: trastuzumab and pertuzumab.

• #51 Salivary gland tumors – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/salivary-gland-cancer/diagnosis-treatment/drc-20354155

  Chemotherapy treats cancer with strong medicines. Chemotherapy isn’t currently used as a standard treatment for salivary gland cancer, but researchers are studying its use. […] Targeted therapy for cancer is a treatment that uses medicines that attack specific chemicals in the cancer cells. […] For salivary gland cancer, immunotherapy may be used on cancer that can’t be removed with surgery. It also may be used for advanced cancers that have spread to other parts of the body or cancer that has come back after treatment. […] Palliative care is a special type of healthcare that helps you feel better when you have a serious illness. If you have cancer, palliative care can help relieve pain and other symptoms.

• #52

  https://link.springer.com/article/10.1007/s12254-020-00614-z

  Salivary gland cancers (SGC) are a rare and heterogeneous group of malignancies. For locally advanced or metastatic disease, chemotherapy has been the mainstay of therapy. […] However, due to advances in the understanding of tumor biology and molecular testing, drugable genetic changes like androgen receptor (AR) status, HER2/neu overexpression and neurotrophic tyrosine receptor kinase (NTRK) gene fusion have evolved as potential therapy targets in subsets of SGC. Consequently therapy with androgen receptor blockade (ARB) can be offered to patients with AR expressing tumors. Anti-HER2 therapy with trastzumab is an option for the treatment of tumors with overexpression of HER2/neu and finally NTRAK inhibitors can be used for tumors harboring a NTRK gene fusion. […] The aim of this review is to recapitulate treatment options for ACC and non-ACC, especially focusing on targeted therapies which are already available for subsets of SGCs.

• #53 Targeted cancer drugs for salivary gland cancer | Cancer Research UK

  https://www.cancerresearchuk.org/about-cancer/salivary-gland-cancer/treatment/targeted

  Targeted drugs work by targeting the differences in cancer cells that help them to grow and survive. They are a treatment for salivary gland cancer when the cancer has spread or other treatments stop working. […] You might have one of these treatments if your salivary gland cancer has a gene change (mutation) or a certain protein that helps the cancer grow. This may be as part of a clinical trial. […] Targeted drugs can help some people with advanced salivary gland cancer. Although these treatments cant cure the cancer, they may help to control it for a time and help some people to live longer. […] If your cancer has an NTRK gene change then you might have the following targeted cancer drugs: larotrectinib (Vitrakvi) and entrectinib (Rozlytrek). […] Certain drugs can target HER2 positive cancers. If you have HER2 positive salivary gland cancer that is advanced or has come back after previous treatment you might have: trastuzumab and pertuzumab.

• #54

  https://link.springer.com/article/10.1007/s12254-020-00614-z

  Active agents that were tested mainly in phase II studies include cisplatin, mitoxantron, epirubicin and vinorelbine. […] Combination therapy with cisplatin, doxorubicin and cyclophosphamide (CAP) provided overall response rates (ORR) between 18-33% in a total of 4 studies. […] A doublet therapy consisting of cisplatin and an anthracycline leads to ORR of roughly 25%. […] Given the fact that chemotherapy has only limited efficacy in ACC, approaches targeting molecular targets were investigated. […] Recently, lenvatinib showed modest activity in a phase II trial of 33 previously treated patients with ACC. […] In the absence of driver mutations, chemotherapy can be offered to these patients. […] Overexpression or amplification of human epidermal growth factor receptor 2 (HER2) is reported in up to 30% of MEC, in 40% of SDC and in 20% of AC NOS.

• #55

  https://link.springer.com/article/10.1007/s12254-020-00614-z

  A very recent phase II study included 57 SDC patients with HER2 overexpression. The combination treatment of trastuzumab and docetaxel showed promising results with an ORR of 70.2% and mOS 39.7 months. […] AR expression is a frequent event in SDC and AC NOS, with rates of up to 90%. Androgen deprivation therapy (ADT) is an option for those patients with AR expression SGC. […] Both compounds are well tolerated and no discontinuation due to adverse events occurred.

• #56 Targeted cancer drugs for salivary gland cancer | Cancer Research UK

  https://www.cancerresearchuk.org/about-cancer/salivary-gland-cancer/treatment/targeted

  Targeted drugs work by targeting the differences in cancer cells that help them to grow and survive. They are a treatment for salivary gland cancer when the cancer has spread or other treatments stop working. […] You might have one of these treatments if your salivary gland cancer has a gene change (mutation) or a certain protein that helps the cancer grow. This may be as part of a clinical trial. […] Targeted drugs can help some people with advanced salivary gland cancer. Although these treatments cant cure the cancer, they may help to control it for a time and help some people to live longer. […] If your cancer has an NTRK gene change then you might have the following targeted cancer drugs: larotrectinib (Vitrakvi) and entrectinib (Rozlytrek). […] Certain drugs can target HER2 positive cancers. If you have HER2 positive salivary gland cancer that is advanced or has come back after previous treatment you might have: trastuzumab and pertuzumab.

• #57

  https://link.springer.com/article/10.1007/s12254-020-00614-z

  A very recent phase II study included 57 SDC patients with HER2 overexpression. The combination treatment of trastuzumab and docetaxel showed promising results with an ORR of 70.2% and mOS 39.7 months. […] AR expression is a frequent event in SDC and AC NOS, with rates of up to 90%. Androgen deprivation therapy (ADT) is an option for those patients with AR expression SGC. […] Both compounds are well tolerated and no discontinuation due to adverse events occurred.

• #58

  https://link.springer.com/article/10.1007/s12254-020-00614-z

  Active agents that were tested mainly in phase II studies include cisplatin, mitoxantron, epirubicin and vinorelbine. […] Combination therapy with cisplatin, doxorubicin and cyclophosphamide (CAP) provided overall response rates (ORR) between 18-33% in a total of 4 studies. […] A doublet therapy consisting of cisplatin and an anthracycline leads to ORR of roughly 25%. […] Given the fact that chemotherapy has only limited efficacy in ACC, approaches targeting molecular targets were investigated. […] Recently, lenvatinib showed modest activity in a phase II trial of 33 previously treated patients with ACC. […] In the absence of driver mutations, chemotherapy can be offered to these patients. […] Overexpression or amplification of human epidermal growth factor receptor 2 (HER2) is reported in up to 30% of MEC, in 40% of SDC and in 20% of AC NOS.

• #59 Targeted cancer drugs for salivary gland cancer | Cancer Research UK

  https://www.cancerresearchuk.org/about-cancer/salivary-gland-cancer/treatment/targeted

  Targeted drugs work by targeting the differences in cancer cells that help them to grow and survive. They are a treatment for salivary gland cancer when the cancer has spread or other treatments stop working. […] You might have one of these treatments if your salivary gland cancer has a gene change (mutation) or a certain protein that helps the cancer grow. This may be as part of a clinical trial. […] Targeted drugs can help some people with advanced salivary gland cancer. Although these treatments cant cure the cancer, they may help to control it for a time and help some people to live longer. […] If your cancer has an NTRK gene change then you might have the following targeted cancer drugs: larotrectinib (Vitrakvi) and entrectinib (Rozlytrek). […] Certain drugs can target HER2 positive cancers. If you have HER2 positive salivary gland cancer that is advanced or has come back after previous treatment you might have: trastuzumab and pertuzumab.

• #60 Salivary Gland Cancer: Symptoms, Causes & Treatment

  https://my.clevelandclinic.org/health/diseases/17965-salivary-gland-cancer

  Chemotherapy uses drugs to destroy cancer cells. You may receive chemotherapy if your cancer has spread from your salivary glands to other tissues outside of your head and neck. […] Your healthcare provider may recommend that you participate in a clinical trial. A clinical trial is research that studies the safety and effectiveness of new treatments. […] Immunotherapy uses drugs to help your immune system identify cancer cells and fight them. Researchers are studying the role of a specific type of immunotherapy called checkpoint inhibitors in fighting metastasized cancer. […] Targeted therapy uses drugs that target weaknesses in a cancer cells genetic code (DNA) to destroy the cancer or stop it from growing. Researchers are studying the effectiveness of targeted therapies in people with adenoid cystic carcinomas that have metastasized.

• #61 5 innovative treatments for salivary gland cancer | MD Anderson Cancer Center

  https://www.mdanderson.org/cancer-types/salivary-gland-cancer/salivary-gland-cancer-treatment.html

  Chemotherapy is not often used in salivary gland cancer, but it can be used in combination with radiation therapy in select cases. […] Targeted therapy drugs are designed to stop or slow the growth or spread of cancer. […] Immune checkpoint inhibitors are only used in select cases. […] Regular follow-up and screenings are vital due to the high risk of salivary gland returning. Patients need to see their doctors every three to six months for the first two years after treatment, since most cancers that recur, or come back, do so within that time. […] Salivary gland patients are also strongly urged not to smoke or drink alcohol during and after treatment.

• #62 Frontiers | Salivary Gland Carcinoma: Novel Targets to Overcome Treatment Resistance in Advanced Disease

  https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2020.580141/full

  Salivary gland carcinomas (SGC) account for less than 5% of head and neck malignant neoplasms, further subcategorized in over 20 histological subtypes. For the most part, treatment for advanced disease is guided by morphology. SGC in general respond poorly to standard chemotherapy, with short durability and significant toxicity. More recently, next-generation sequencing provided significant input on the molecular characterization of each SGC subtype, not only improving diagnostic differentiation between morphologically similar tumor types, but also identifying novel driver pathways that determine tumor biology and may be amenable to targeted therapy. […] Treatment for metastatic disease is still mostly based on chemotherapy, despite low response, and survival rates. Currently, encouraging progress in immunohistochemical and molecular alterations, such as the presence of an NTRK fusion, overexpression of Her-2 and androgen receptor, has been made to improve outcomes with targeted therapy.

• #63 5 innovative treatments for salivary gland cancer | MD Anderson Cancer Center

  https://www.mdanderson.org/cancer-types/salivary-gland-cancer/salivary-gland-cancer-treatment.html

  Chemotherapy is not often used in salivary gland cancer, but it can be used in combination with radiation therapy in select cases. […] Targeted therapy drugs are designed to stop or slow the growth or spread of cancer. […] Immune checkpoint inhibitors are only used in select cases. […] Regular follow-up and screenings are vital due to the high risk of salivary gland returning. Patients need to see their doctors every three to six months for the first two years after treatment, since most cancers that recur, or come back, do so within that time. […] Salivary gland patients are also strongly urged not to smoke or drink alcohol during and after treatment.

• #64 Salivary gland tumors – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/salivary-gland-cancer/diagnosis-treatment/drc-20354155

  Chemotherapy treats cancer with strong medicines. Chemotherapy isn’t currently used as a standard treatment for salivary gland cancer, but researchers are studying its use. […] Targeted therapy for cancer is a treatment that uses medicines that attack specific chemicals in the cancer cells. […] For salivary gland cancer, immunotherapy may be used on cancer that can’t be removed with surgery. It also may be used for advanced cancers that have spread to other parts of the body or cancer that has come back after treatment. […] Palliative care is a special type of healthcare that helps you feel better when you have a serious illness. If you have cancer, palliative care can help relieve pain and other symptoms.

• #65 Salivary gland tumors | UM Health-Sparrow

  https://www.uofmhealthsparrow.org/departments-conditions/conditions/salivary-gland-tumors

  Targeted therapy for cancer is a treatment that uses medicines that attack specific chemicals in the cancer cells. […] For salivary gland cancer, targeted therapy may be used when the cancer can’t be removed with surgery. It also may be used for advanced cancers that spread to other parts of the body or cancer that comes back after treatment. […] Immunotherapy for cancer is a treatment with medicine that helps the body’s immune system kill cancer cells. […] For salivary gland cancer, immunotherapy may be used on cancer that can’t be removed with surgery. It also may be used for advanced cancers that have spread to other parts of the body or cancer that has come back after treatment. […] Palliative care is a special type of healthcare that helps you feel better when you have a serious illness. If you have cancer, palliative care can help relieve pain and other symptoms.

• #66 Targeted cancer drugs for salivary gland cancer | Cancer Research UK

  https://www.cancerresearchuk.org/about-cancer/salivary-gland-cancer/treatment/targeted

  A type of hormone treatment can attach to these receptors and stop the cancer from growing. These drugs are called anti androgens. […] If you have advanced or metastatic salivary gland cancer you might have anti androgen treatment. An example of an anti androgen is the drug bicalutamide. […] Researchers are trying to find better treatments for salivary gland cancer. This includes learning more about the genetic make-up of individual cancers and developing different types of targeted drugs and immunotherapies. […] You might be offered immunotherapy as part of a clinical trial.

• #67 Salivary Gland Cancer: Symptoms, Causes & Treatment

  https://my.clevelandclinic.org/health/diseases/17965-salivary-gland-cancer

  Chemotherapy uses drugs to destroy cancer cells. You may receive chemotherapy if your cancer has spread from your salivary glands to other tissues outside of your head and neck. […] Your healthcare provider may recommend that you participate in a clinical trial. A clinical trial is research that studies the safety and effectiveness of new treatments. […] Immunotherapy uses drugs to help your immune system identify cancer cells and fight them. Researchers are studying the role of a specific type of immunotherapy called checkpoint inhibitors in fighting metastasized cancer. […] Targeted therapy uses drugs that target weaknesses in a cancer cells genetic code (DNA) to destroy the cancer or stop it from growing. Researchers are studying the effectiveness of targeted therapies in people with adenoid cystic carcinomas that have metastasized.

• #68 Salivary Gland Cancer Treatment by Stage | Salivary Cancer Treatment | American Cancer Society

  https://www.cancer.org/cancer/types/salivary-gland-cancer/treating/by-stage.html

  The treatment options for salivary gland cancer depend largely on the type and stage (extent) of the cancer. But other factors, such as the grade of the cancer (how likely it is to grow and spread); and a persons overall health, can also be important. […] Since salivary gland cancers are rare and can be hard to treat, clinical trials might be a good option to think about. […] If you have stage I salivary gland cancer, your doctors will probably recommend surgery to remove the cancer and part or all of the salivary gland. […] Radiation therapy might be advised after surgery if you have an intermediate- or high-grade cancer or an adenoid cystic carcinoma, if the cancer could not be removed completely, if the edges of the removed area have cancer cells (a sign that some cancer might have been left behind), or if the cancer is invading (growing into) nearby nerves.

• #69 Treating Salivary Gland Cancer | How is Salivary Cancer Treated? | American Cancer Society

  https://www.cancer.org/cancer/types/salivary-gland-cancer/treating.html

  If you’ve been diagnosed with salivary gland cancer, your cancer care team will discuss your treatment options with you. It’s important to weigh the benefits of each treatment option against the possible risks and side effects. […] Common treatment options for salivary gland cancer include: Surgery for Salivary Gland Cancer, Radiation Therapy for Salivary Gland Cancer, Chemotherapy for Salivary Gland Cancer, Targeted Drug Therapy for Salivary Gland Cancer, Immunotherapy for Salivary Gland Cancer. […] Sometimes more than one type of treatment is used. Which treatment option(s) might be best for you depends on many factors, including the type, grade, and stage of the cancer; your overall health; the chances of curing the disease; the impact of the treatment on functions like speech, chewing, and swallowing; and your own personal preferences.

• #70 Salivary Gland Cancer Treatment by Stage | Salivary Cancer Treatment | American Cancer Society

  https://www.cancer.org/cancer/types/salivary-gland-cancer/treating/by-stage.html

  The treatment options for salivary gland cancer depend largely on the type and stage (extent) of the cancer. But other factors, such as the grade of the cancer (how likely it is to grow and spread); and a persons overall health, can also be important. […] Since salivary gland cancers are rare and can be hard to treat, clinical trials might be a good option to think about. […] If you have stage I salivary gland cancer, your doctors will probably recommend surgery to remove the cancer and part or all of the salivary gland. […] Radiation therapy might be advised after surgery if you have an intermediate- or high-grade cancer or an adenoid cystic carcinoma, if the cancer could not be removed completely, if the edges of the removed area have cancer cells (a sign that some cancer might have been left behind), or if the cancer is invading (growing into) nearby nerves.

• #71 Treatments for salivary gland cancer | Canadian Cancer Society

  https://cancer.ca/en/cancer-information/cancer-types/salivary-gland/treatment

  If you have salivary gland cancer, your healthcare team will create a treatment plan just for you. It will be based on your health and specific information about the cancer. When deciding which treatments to offer for salivary gland cancer, your healthcare team will consider […] You may be offered one or more of the following treatments for salivary gland cancer. […] The main treatment for stage 1 salivary gland cancer is surgery. […] Stage 2 salivary gland cancer is treated with surgery and radiation therapy. […] Treatment for stage 3 salivary gland cancer depends upon the grade of the cancer. […] Radiation therapy is the main treatment for stage 4 salivary gland cancer. […] There are no standard treatment options for recurrent salivary gland cancer. Treatments that may be offered include radiation therapy and surgery. Chemotherapy is offered in rare cases.

• #72 Salivary Gland Cancer Treatment by Stage | Salivary Cancer Treatment | American Cancer Society

  https://www.cancer.org/cancer/types/salivary-gland-cancer/treating/by-stage.html

  The treatment options for salivary gland cancer depend largely on the type and stage (extent) of the cancer. But other factors, such as the grade of the cancer (how likely it is to grow and spread); and a persons overall health, can also be important. […] Since salivary gland cancers are rare and can be hard to treat, clinical trials might be a good option to think about. […] If you have stage I salivary gland cancer, your doctors will probably recommend surgery to remove the cancer and part or all of the salivary gland. […] Radiation therapy might be advised after surgery if you have an intermediate- or high-grade cancer or an adenoid cystic carcinoma, if the cancer could not be removed completely, if the edges of the removed area have cancer cells (a sign that some cancer might have been left behind), or if the cancer is invading (growing into) nearby nerves.

• #73 Salivary Gland Cancer Treatment by Stage | Salivary Cancer Treatment | American Cancer Society

  https://www.cancer.org/cancer/types/salivary-gland-cancer/treating/by-stage.html

  Radiation therapy may be given after surgery if your cancer is intermediate- or high-grade or an adenoid cystic carcinoma, if the cancer could not be removed completely, if the cancer is invading nearby blood vessels, lymph vessels, or nerves; if the removed lymph nodes have cancer; or if the edges of the removed tissue contain cancer cells. Chemotherapy might be given along with radiation in certain cases, but this combination treatment is still being studied. […] Radiation therapy might be an option as the main treatment if surgery would result in serious problems with eating, speech, or appearance, or for people who refuse surgery. […] Doctors generally recommend extensive surgery (removing the salivary gland containing the tumor, nearby tissues, and lymph nodes in your neck on the same side) if its possible.

• #74 Treatments for salivary gland cancer | Canadian Cancer Society

  https://cancer.ca/en/cancer-information/cancer-types/salivary-gland/treatment

  If you have salivary gland cancer, your healthcare team will create a treatment plan just for you. It will be based on your health and specific information about the cancer. When deciding which treatments to offer for salivary gland cancer, your healthcare team will consider […] You may be offered one or more of the following treatments for salivary gland cancer. […] The main treatment for stage 1 salivary gland cancer is surgery. […] Stage 2 salivary gland cancer is treated with surgery and radiation therapy. […] Treatment for stage 3 salivary gland cancer depends upon the grade of the cancer. […] Radiation therapy is the main treatment for stage 4 salivary gland cancer. […] There are no standard treatment options for recurrent salivary gland cancer. Treatments that may be offered include radiation therapy and surgery. Chemotherapy is offered in rare cases.

• #75 Salivary Gland Tumors – What You Need To Know – American Head & Neck Society

  https://www.ahns.info/salivary-gland/sg-tumors-what-you-need-to-know/

  Surgery to remove tumor with removal of lymph nodes for tumors with high grade (aggressive) pathology. Radiation with or without chemotherapy following surgery depending on surgical pathology. Cancers that can be completely removed with clear margins, no lymph node or nerve spread and low grade on pathology, can often be treated with surgery alone. […] Radiation with or without chemotherapy can be considered for patients that cannot have surgery. […] Surgery to remove tumor with neck dissection to remove lymph nodes. Radiation therapy with possible chemotherapy following surgery. […] Radiation may be considered in selected cases to help with symptoms. […] Most salivary gland cancers are treated with surgery first. If surgery cannot be performed or the cancer has certain high-risk features, chemotherapy may be recommended. This is usually given with radiation therapy to decrease the risk of the cancer recurring.

• #76 Salivary Gland Cancer Treatment by Stage | Salivary Cancer Treatment | American Cancer Society

  https://www.cancer.org/cancer/types/salivary-gland-cancer/treating/by-stage.html

  But in other cases, especially for high-grade tumors or adenoid cystic cancer, surgery is often followed by radiation therapy. […] Radiation therapy (with or without chemo) may be used as the main treatment if surgery is not a good option (for example, if surgical removal of the cancer would cause serious problems with eating, speech, or appearance, or if someone is not healthy enough to have surgery). […] Some of these cancers might be treated with surgery if the doctor feels all of the cancer can be removed. (This would be followed by radiation therapy and maybe chemo.) […] But most often, radiation therapy is used as the main treatment to try to shrink the tumor(s) and relieve pain, bleeding, or other symptoms. […] If the cancer recurs locally and is thought to be resectable (able to be removed completely), surgery is usually the treatment of choice. This is often followed by radiation therapy if it wasnt given before.

• #77 Salivary Gland Cancer Treatment – NCI

  https://www.cancer.gov/types/head-and-neck/patient/adult/salivary-gland-treatment-pdq

  Treatment of stage IVA, stage IVB, and stage IVC salivary gland cancer may include the following: Fast-neutron or photon-beam radiation therapy, A clinical trial of chemotherapy with or without radiation therapy. […] Treatment of recurrent salivary gland cancer may include the following: Radiation therapy, A clinical trial of a new treatment.

• #78 Treatments for stage 4 salivary gland cancer | Canadian Cancer Society

  https://cancer.ca/en/cancer-information/cancer-types/salivary-gland/treatment/stage-4

  The following are treatment options for stage 4 salivary gland cancer. Your healthcare team will suggest treatments based on your needs and work with you to develop a treatment plan. […] External radiation therapy is the main treatment for stage 4 salivary gland cancer. It can be used to shrink cancer that is in the salivary gland and lymph nodes in the neck to help reduce symptoms like pain and bleeding. It is also given after surgery when it is used as part of the treatment. […] Surgery may be offered to some people with stage 4 salivary gland cancer because it generally gives the best chance of completely removing it. To have surgery, the cancer must not have spread to other (distant) organs. […] Chemotherapy may be offered for stage 4 salivary gland cancer that has spread to distant organs. It may also be offered to people who do not want to have surgery or radiation therapy.

• #79 Salivary Gland Cancer Treatment by Stage | Salivary Cancer Treatment | American Cancer Society

  https://www.cancer.org/cancer/types/salivary-gland-cancer/treating/by-stage.html

  But in other cases, especially for high-grade tumors or adenoid cystic cancer, surgery is often followed by radiation therapy. […] Radiation therapy (with or without chemo) may be used as the main treatment if surgery is not a good option (for example, if surgical removal of the cancer would cause serious problems with eating, speech, or appearance, or if someone is not healthy enough to have surgery). […] Some of these cancers might be treated with surgery if the doctor feels all of the cancer can be removed. (This would be followed by radiation therapy and maybe chemo.) […] But most often, radiation therapy is used as the main treatment to try to shrink the tumor(s) and relieve pain, bleeding, or other symptoms. […] If the cancer recurs locally and is thought to be resectable (able to be removed completely), surgery is usually the treatment of choice. This is often followed by radiation therapy if it wasnt given before.

• #80 Salivary Gland Cancer Treatment by Stage | Salivary Cancer Treatment | American Cancer Society

  https://www.cancer.org/cancer/types/salivary-gland-cancer/treating/by-stage.html

  If the cancer returns in the area where it started (local) but is not resectable, radiation therapy may be an option. Chemotherapy (chemo) might be used along with the radiation or by itself (especially if radiation therapy was already used the first time). […] Salivary gland cancers that come back in distant parts of the body are usually treated with chemo or targeted drug therapy.

• #81 Salivary Gland Cancer Treatment – NCI

  https://www.cancer.gov/types/head-and-neck/patient/adult/salivary-gland-treatment-pdq

  Radiation therapy is a cancer treatment that uses high-energy x-rays or other types of radiation to kill cancer cells or keep them from growing. […] External radiation therapy is used to treat salivary gland cancer and may also be used as palliative therapy to relieve symptoms and improve quality of life. […] Chemotherapy is a cancer treatment that uses drugs to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. […] New types of treatment are being tested in clinical trials. […] Treatment for salivary gland cancer may cause side effects. […] Patients may want to think about taking part in a clinical trial. […] Treatment for stage I salivary gland cancer depends on whether the cancer is low-grade (slow growing) or high-grade (fast growing).

• #82 Treatments for stage 4 salivary gland cancer | Canadian Cancer Society

  https://cancer.ca/en/cancer-information/cancer-types/salivary-gland/treatment/stage-4

  Targeted therapy may be offered for stage 4 salivary gland cancer if the cancer cells have certain genetic changes that are identified using cell and tissue studies. […] You may want to consider a type of care to make you feel better without treating the cancer itself. This may be because the cancer treatments don’t work anymore, they’re not likely to improve your condition or they may cause side effects that are hard to cope with. There may also be other reasons why you can’t have or don’t want cancer treatment. […] Talk to your doctor about clinical trials open to people with salivary gland cancer in Canada. Clinical trials look at new ways to prevent, find and treat cancer.

• #83 Salivary Gland Cancer: Symptoms, Causes & Treatment

  https://my.clevelandclinic.org/health/diseases/17965-salivary-gland-cancer

  Radiosensitizers are drugs that make cancer cells more sensitive to radiation. Research is ongoing into how radiosensitizers and radiation therapy can help with salivary gland cancer treatment. […] Depending on your cancer, you may receive a combination of treatments to remove the cancer and prevent it from growing back (recurring).

• #84 Targeted cancer drugs for salivary gland cancer | Cancer Research UK

  https://www.cancerresearchuk.org/about-cancer/salivary-gland-cancer/treatment/targeted

  A type of hormone treatment can attach to these receptors and stop the cancer from growing. These drugs are called anti androgens. […] If you have advanced or metastatic salivary gland cancer you might have anti androgen treatment. An example of an anti androgen is the drug bicalutamide. […] Researchers are trying to find better treatments for salivary gland cancer. This includes learning more about the genetic make-up of individual cancers and developing different types of targeted drugs and immunotherapies. […] You might be offered immunotherapy as part of a clinical trial.

• #85

  https://link.springer.com/article/10.1007/s12254-020-00614-z

  A very recent phase II study included 57 SDC patients with HER2 overexpression. The combination treatment of trastuzumab and docetaxel showed promising results with an ORR of 70.2% and mOS 39.7 months. […] AR expression is a frequent event in SDC and AC NOS, with rates of up to 90%. Androgen deprivation therapy (ADT) is an option for those patients with AR expression SGC. […] Both compounds are well tolerated and no discontinuation due to adverse events occurred.

• #86 Systemic therapy for recurrent or metastatic salivary gland malignancies | Cancers of the Head & Neck | Full Text

  https://cancersheadneck.biomedcentral.com/articles/10.1186/s41199-016-0011-z

  The limited utility and efficacy of cytotoxic chemotherapy have compelled the need for systematic study of alternative therapies for advanced salivary gland carcinomas. […] Although no prospective studies have been conducted, it is worthwhile mentioning the data for androgen deprivation in SDC as several reports have emerged in recent years and results have been promising. […] Currently, a randomized trial is underway in Europe to study the efficacy of androgen deprivation therapy in androgen receptor-positive salivary cancers (NCT01969578). […] To date, there are no biologic therapies or combinations with chemotherapy that have a clear benefit for patients with advanced salivary cancer. […] Despite the overall modest results of new trials of chemotherapeutic and biologic agents, there are some notable glimmers of hope on the horizon for the treatment of advanced salivary cancers.

• #87 Salivary gland tumors – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/salivary-gland-cancer/diagnosis-treatment/drc-20354155

  Chemotherapy treats cancer with strong medicines. Chemotherapy isn’t currently used as a standard treatment for salivary gland cancer, but researchers are studying its use. […] Targeted therapy for cancer is a treatment that uses medicines that attack specific chemicals in the cancer cells. […] For salivary gland cancer, immunotherapy may be used on cancer that can’t be removed with surgery. It also may be used for advanced cancers that have spread to other parts of the body or cancer that has come back after treatment. […] Palliative care is a special type of healthcare that helps you feel better when you have a serious illness. If you have cancer, palliative care can help relieve pain and other symptoms.

• #88 Support for Salivary Gland Cancer | NYU Langone Health

  https://nyulangone.org/conditions/salivary-gland-cancer/support

  Doctors, nurses, nurse practitioners, physician assistants, social workers, and rehabilitation specialists at NYU Langones Perlmutter Cancer Center and Rusk Rehabilitation collaborate to provide support for people with salivary gland cancer throughout diagnosis and treatment and during follow-up appointments. […] Speech and swallowing therapy may be used throughout treatment to preserve as much function as possible. It may also be given afterward to help you regain or compensate for any lost function. Therapy usually consists of exercises to strengthen the muscles in the tongue, mouth, vocal cords, and throat. […] If the facial nerve had to be sacrificed, all or part of the nerve can be reconstructed with nerve grafts to help restore facial muscle function. Surgeons may also reposition other muscles adjacent to the face or transfer muscles from other areas of the body. NYU Langone surgeons are experts at restoring as much function as possible.

• #89 Support for Salivary Gland Cancer | NYU Langone Health

  https://nyulangone.org/conditions/salivary-gland-cancer/support

  Doctors, nurses, nurse practitioners, physician assistants, social workers, and rehabilitation specialists at NYU Langones Perlmutter Cancer Center and Rusk Rehabilitation collaborate to provide support for people with salivary gland cancer throughout diagnosis and treatment and during follow-up appointments. […] Speech and swallowing therapy may be used throughout treatment to preserve as much function as possible. It may also be given afterward to help you regain or compensate for any lost function. Therapy usually consists of exercises to strengthen the muscles in the tongue, mouth, vocal cords, and throat. […] If the facial nerve had to be sacrificed, all or part of the nerve can be reconstructed with nerve grafts to help restore facial muscle function. Surgeons may also reposition other muscles adjacent to the face or transfer muscles from other areas of the body. NYU Langone surgeons are experts at restoring as much function as possible.

• #90 Support for Salivary Gland Cancer | NYU Langone Health

  https://nyulangone.org/conditions/salivary-gland-cancer/support

  Radiation therapy and surgery for salivary gland cancer may cause muscle stiffness in the face, jaw, neck, and shoulders. Physical therapists and speech and swallowing therapists at Rusk Rehabilitation can teach you range-of-motion exercises, stretches, and relaxation techniques to help provide relief. […] Because salivary gland cancer treatment may cause difficulty with swallowing, you may need a nutritional assessment and dietary plan. Throughout your treatment and recovery, nutritionists at Perlmutter Cancer Center can help ensure you’re getting the nutrients you need in easy-to-swallow foods. […] A physiatrist can evaluate you and prescribe physical therapy at Rusk Rehabilitation. Physical therapy often includes range-of-motion and flexibility exercises. This is usually followed by specialized massage therapy to help the lymph fluid to drain.

• #91 Support for Salivary Gland Cancer | NYU Langone Health

  https://nyulangone.org/conditions/salivary-gland-cancer/support

  Doctors at Rusk Rehabilitation may prescribe medication to ease the discomfort of neuropathy. They can also prescribe physical therapy to help ensure that neuropathy doesn’t interfere with your balance, strength, or ability to walk and perform daily activities. […] If you are experiencing fatigue due to salivary gland cancer or its treatment, doctors may recommend physical and occupational therapy at Rusk Rehabilitation. This type of therapy may include strength and aerobic exercises to address fatigue caused by surgery, radiation therapy, or chemotherapy. […] Supportive care specialists at Perlmutter Cancer Center provide ongoing therapy for any cancer-related or treatment-related symptoms, such as pain, fatigue, loss of appetite, or stress, helping improve quality of life.

• #92 Salivary gland tumors – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/salivary-gland-cancer/diagnosis-treatment/drc-20354155

  Chemotherapy treats cancer with strong medicines. Chemotherapy isn’t currently used as a standard treatment for salivary gland cancer, but researchers are studying its use. […] Targeted therapy for cancer is a treatment that uses medicines that attack specific chemicals in the cancer cells. […] For salivary gland cancer, immunotherapy may be used on cancer that can’t be removed with surgery. It also may be used for advanced cancers that have spread to other parts of the body or cancer that has come back after treatment. […] Palliative care is a special type of healthcare that helps you feel better when you have a serious illness. If you have cancer, palliative care can help relieve pain and other symptoms.

• #93 Treatments for stage 4 salivary gland cancer | Canadian Cancer Society

  https://cancer.ca/en/cancer-information/cancer-types/salivary-gland/treatment/stage-4

  Targeted therapy may be offered for stage 4 salivary gland cancer if the cancer cells have certain genetic changes that are identified using cell and tissue studies. […] You may want to consider a type of care to make you feel better without treating the cancer itself. This may be because the cancer treatments don’t work anymore, they’re not likely to improve your condition or they may cause side effects that are hard to cope with. There may also be other reasons why you can’t have or don’t want cancer treatment. […] Talk to your doctor about clinical trials open to people with salivary gland cancer in Canada. Clinical trials look at new ways to prevent, find and treat cancer.

• #94 Salivary gland cancer | Macmillan Cancer Support

  https://www.macmillan.org.uk/cancer-information-and-support/head-and-neck-cancer/salivary-gland-cancer

  Treatment for salivary gland cancer includes surgery, radiotherapy and chemotherapy. […] A team of specialists will meet to discuss the best possible treatment for you. This is called a multidisciplinary team (MDT). […] Your treatment depends on: the position of the cancer, the type of cancer cell, the stage and grade of the cancer, your general health. […] For early-stage salivary gland cancer, you may only need one type of treatment. But sometimes 2 or more treatments are given, if the cancer is larger or has started to spread. […] Treatment for salivary gland cancer may include: Surgery. Surgery is usually the main treatment for salivary gland cancer. […] If the cancer is small and has not spread, the surgeon may only need to remove part or all of the salivary gland. […] Radiotherapy uses high-energy rays to destroy the cancer cells.

• #95 5 innovative treatments for salivary gland cancer | MD Anderson Cancer Center

  https://www.mdanderson.org/cancer-types/salivary-gland-cancer/salivary-gland-cancer-treatment.html

  Treatment plans for salivary gland cancer can change drastically based on the tumors exact location and subtype. The right treatment plan can greatly reduce the chance of the cancer returning and help maintain your quality of life, including your ability to speak, swallow and hear. […] At MD Anderson you will get care from a team of salivary gland cancer experts, including a surgeon, radiation oncologist and medical oncologist. They will work together closely to discuss your case and develop a treatment plan tailored to you. […] Treatments can include many cutting-edge interventions, such as proton therapy, targeted therapy and advanced robotic surgeries. […] Surgery is the primary treatment for most salivary gland cancers. […] For salivary gland cancer, radiation therapy is typically used after surgery to kill any remaining cancer cells. It is also used when surgery isn’t possible.

• #96 Treating Salivary Gland Cancer | How is Salivary Cancer Treated? | American Cancer Society

  https://www.cancer.org/cancer/types/salivary-gland-cancer/treating.html

  If you’ve been diagnosed with salivary gland cancer, your cancer care team will discuss your treatment options with you. It’s important to weigh the benefits of each treatment option against the possible risks and side effects. […] Common treatment options for salivary gland cancer include: Surgery for Salivary Gland Cancer, Radiation Therapy for Salivary Gland Cancer, Chemotherapy for Salivary Gland Cancer, Targeted Drug Therapy for Salivary Gland Cancer, Immunotherapy for Salivary Gland Cancer. […] Sometimes more than one type of treatment is used. Which treatment option(s) might be best for you depends on many factors, including the type, grade, and stage of the cancer; your overall health; the chances of curing the disease; the impact of the treatment on functions like speech, chewing, and swallowing; and your own personal preferences.

• #97 Salivary gland cancer | Macmillan Cancer Support

  https://www.macmillan.org.uk/cancer-information-and-support/head-and-neck-cancer/salivary-gland-cancer

  Treatment for salivary gland cancer includes surgery, radiotherapy and chemotherapy. […] A team of specialists will meet to discuss the best possible treatment for you. This is called a multidisciplinary team (MDT). […] Your treatment depends on: the position of the cancer, the type of cancer cell, the stage and grade of the cancer, your general health. […] For early-stage salivary gland cancer, you may only need one type of treatment. But sometimes 2 or more treatments are given, if the cancer is larger or has started to spread. […] Treatment for salivary gland cancer may include: Surgery. Surgery is usually the main treatment for salivary gland cancer. […] If the cancer is small and has not spread, the surgeon may only need to remove part or all of the salivary gland. […] Radiotherapy uses high-energy rays to destroy the cancer cells.

• #98 Management of salivary gland carcinomas – a review

  https://pmc.ncbi.nlm.nih.gov/articles/PMC5354805/

  Complete surgical resection, with adequate free margins, is currently the mainstay treatment for SGCs. […] Postoperative radiotherapy (PORT) can be used as an adjuvant therapy in patients with high-risk factors. […] In addition, very few clinical trials were designed to investigate the efficacy of novel treatment strategies. […] In summary, surgery predominates the treatment for SGCs, and PORT was recommended in patients with adverse prognostic factors, such as T3 or T4 tumors, close or incomplete resection margins, high grade, perineural or vascular invasion, and positive lymph nodes. […] For patients with inoperable disease, those who refuse surgery or those who have an unresectable tumor, primary RT should be considered. […] Chemotherapy as palliative treatment to deal with the patients with recurrent and/or metastatic disease, which has been proven to be of limited effect, and no chemotherapy regimen has been the effort to prolong or improve OS or DFS in these tumors.

• #99 Salivary Gland Cancer Treatment | Memorial Sloan Kettering Cancer Center

  https://www.mskcc.org/cancer-care/types/salivary-gland/salivary-gland-cancer-treatment

  There are several ways to treat salivary gland cancer, depending on the location, the stage, and the type of cancer, including: surgery to remove the cancer, radiation therapy, using high-energy rays (such as x-rays) to destroy the cancer cells, drug therapies that kill cancer cells. […] Most treatment plans involve surgery. Radiation therapy is also a very common and effective part of the care plan. Chemotherapy is more often recommended for advanced salivary gland cancers, and it may be offered through a clinical trial. […] Our goal at Memorial Sloan Kettering is to give compassionate, personalized care to every person who comes to us for salivary gland cancer treatment. Your team of salivary gland cancer experts will design a treatment plan especially for you. Their specialties include surgery, radiation therapy, drug therapy, reconstruction, rehabilitation, and quality-of-life issues.

• #100 Systemic therapy for recurrent or metastatic salivary gland malignancies | Cancers of the Head & Neck | Full Text

  https://cancersheadneck.biomedcentral.com/articles/10.1186/s41199-016-0011-z

  Salivary gland carcinomas are notoriously resistant to therapy and no standard of care exists. […] Every effort should be made to treat salivary gland malignancies under a clinical protocol and/or at a large multidisciplinary practice with clinicians experienced in treating these malignancies. […] Surgical resection is the cornerstone of treatment for salivary gland malignancies. Radiotherapy is often employed as adjuvant therapy for tumors deemed to be at high risk of recurrence or as definitive treatment when surgical resection is not feasible. […] The primary use of chemotherapy or systemic therapy is for patients with recurrent or metastatic disease for whom surgery or radiotherapy is not possible. […] The potential benefit of adding platinum chemotherapy to adjuvant radiotherapy for high-risk salivary cancer is currently under investigation in RTOG 1008 (NCT01220583), and the results of this randomized trial will hopefully inform future management.

• #101

  https://link.springer.com/article/10.1007/s12254-020-00614-z

  Salivary gland cancers (SGC) are a rare and heterogeneous group of malignancies. For locally advanced or metastatic disease, chemotherapy has been the mainstay of therapy. […] However, due to advances in the understanding of tumor biology and molecular testing, drugable genetic changes like androgen receptor (AR) status, HER2/neu overexpression and neurotrophic tyrosine receptor kinase (NTRK) gene fusion have evolved as potential therapy targets in subsets of SGC. Consequently therapy with androgen receptor blockade (ARB) can be offered to patients with AR expressing tumors. Anti-HER2 therapy with trastzumab is an option for the treatment of tumors with overexpression of HER2/neu and finally NTRAK inhibitors can be used for tumors harboring a NTRK gene fusion. […] The aim of this review is to recapitulate treatment options for ACC and non-ACC, especially focusing on targeted therapies which are already available for subsets of SGCs.

• #102 Frontiers | Salivary Gland Carcinoma: Novel Targets to Overcome Treatment Resistance in Advanced Disease

  https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2020.580141/full

  Despite response rates of <30%, chemotherapy remains one of the most used treatments for this condition. The most consolidated regimen consists of cisplatin, doxorubicin and cyclophosphamide. [...] We propose a practical approach for newly diagnosed advanced ACC and options for later lines of therapy. [...] In conclusion, SGCs may be challenging to treat due to its several histological subtypes. Molecular diagnostics are able to aid in diagnosis and guide discovery for subtype-specific targeted therapy. Currently, significant efforts are being undertaken to improve outcomes for advanced disease with biomarker-driven research. Given the limited efficacy with chemotherapy, a more personalized approach is of utmost importance to move forward in the management of this infrequent entity.

• #103 Systemic therapy for recurrent or metastatic salivary gland malignancies | Cancers of the Head & Neck | Full Text

  https://cancersheadneck.biomedcentral.com/articles/10.1186/s41199-016-0011-z

  The limited utility and efficacy of cytotoxic chemotherapy have compelled the need for systematic study of alternative therapies for advanced salivary gland carcinomas. […] Although no prospective studies have been conducted, it is worthwhile mentioning the data for androgen deprivation in SDC as several reports have emerged in recent years and results have been promising. […] Currently, a randomized trial is underway in Europe to study the efficacy of androgen deprivation therapy in androgen receptor-positive salivary cancers (NCT01969578). […] To date, there are no biologic therapies or combinations with chemotherapy that have a clear benefit for patients with advanced salivary cancer. […] Despite the overall modest results of new trials of chemotherapeutic and biologic agents, there are some notable glimmers of hope on the horizon for the treatment of advanced salivary cancers.

• #104 Systemic therapy for recurrent or metastatic salivary gland malignancies | Cancers of the Head & Neck | Full Text

  https://cancersheadneck.biomedcentral.com/articles/10.1186/s41199-016-0011-z

  The use of hormone therapy and anti-HER2 therapy for salivary duct carcinoma or AR+/HER2+ adenocarcinoma is a treatment approach that should continue to be refined and investigated. […] Given the clinical rarity and nuances of each salivary cancer subtype and the changing academic landscape with a steadily increasing number of therapeutic options and clinical trials, management by an experienced head and neck medical oncologist at a tertiary referral center or academic institution is preferred if possible.

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