Materiały źródłowe

• #1

  https://www.nhs.uk/conditions/alzheimers-disease/prevention/

  As the exact cause of Alzheimer’s disease is still unknown, there’s no certain way to prevent the condition. But a healthy lifestyle can help reduce your risk. […] The research concluded that by modifying all the risk factors we’re able to change, our risk of dementia could be significantly reduced. […] It may be possible to reduce your risk of Alzheimer’s disease and other types of dementia by: reading, learning foreign languages, playing musical instruments, volunteering in your local community, taking part in group sports, such as bowling, trying new activities or hobbies, maintaining an active social life.

• #2 Reducing Risk for Dementia | Alzheimer’s Disease and Dementia | CDC

  https://www.cdc.gov/alzheimers-dementia/prevention/index.html

  There are common conditions and lifestyle behaviors that can increase your risk for dementia. […] Learn what they are and the healthy lifestyle habits that can lower your risk of developing dementia, including Alzheimer’s disease. […] Nearly 45% of all dementia cases may be prevented or delayed. […] Small changes can make a big difference to lower your risk of dementia. […] Healthy habits can benefit brain health by: […] Slowing the progression of dementia, including Alzheimer’s. […] Regular physical activity can help you prevent, delay, or manage chronic diseases, like dementia. […] The good news is type 2 diabetes can be prevented or delayed. […] High blood pressure can damage blood vessels and limit blood flow to the brain, which does damage to the brain. […] Treating hearing loss (using hearing aids) may reduce the risk of dementia. […] Current smoking also increases the risk of developing dementia, including Alzheimer’s disease. […] Quit smoking to reduce your risk dementia. Quitting smoking also reduces other risks for dementia, like stroke, type 2 diabetes, and high blood pressure.

• #3 Lancet Commission identifies two new risk factors for dementia and suggests 45% of cases could be delayed or reduced | Alzheimer’s Disease International (ADI)

  https://www.alzint.org/news-events/news/lancet-commission-identifies-two-new-risk-factors-for-dementia-and-suggests-45-of-cases-could-be-delayed-or-reduced/

  New research commissioned by The Lancet reveals that 45% of cases of dementia could potentially be delayed or reduced, marking a 5% increase from their 2020 findings. […] The study also indicated that addressing most risk factors in mid-life (18-65) had the greatest impact in delaying or preventing the onset of dementia later in life. […] This study underscores the critical importance of a life-course approach to risk reduction, with targeted interventions across different stages of life. By identifying and addressing these risk factors early on, particularly in lower resourced settings, we have a profound opportunity to reduce the global impact of dementia. […] In 2023, ADI published its World Alzheimer Report titled “Reducing Dementia Risk: Never Too Early, Never Too Late.” The report provides practical and tangible examples of dementia risk reduction from around the globe.

• #4 Addressing 14 health and lifestyle factors could prevent nearly half of global dementia cases – Alzheimer’s Research UK

  https://www.alzheimersresearchuk.org/news/nearly-half-of-global-dementia-cases-could-be-prevented-or-delayed-by-addressing-14-health-and-lifestyle-factors-says-new-report/

  It was a milestone: the first major global consensus on the preventable nature of dementia, suggesting that around a third of cases were linked to these factors. […] Three years later, in 2020, the researchers updated their report in light of new evidence, adding three new risk factors to the list, and suggesting that around 40% of cases were linked to these so-called ‘modifiable’ risk factors. […] Taken together, the researchers calculate that these 14 risk factors account for almost half (45%) of all dementia cases around the world. […] The researchers calculate that if, as a society and as individuals, we could completely address these 14 health and lifestyle factors it could prevent or delay nearly half (45%) of dementia cases. […] What this research is saying is that dementia is more common among people who have one or more of these risk factors.

• #4 Addressing 14 health and lifestyle factors could prevent nearly half of global dementia cases – Alzheimer’s Research UK

  https://www.alzheimersresearchuk.org/news/nearly-half-of-global-dementia-cases-could-be-prevented-or-delayed-by-addressing-14-health-and-lifestyle-factors-says-new-report/

  But as the Lancet Commission’s findings show, dementia isn’t an inevitable part ageing, and there are things we can all do to reduce our risk of developing dementia in the future. […] The good news is that this provides a huge opportunity to take steps throughout our lives to keep our brains healthy and lessen the devastating impact of dementia on our society and our loved ones in future. […] Tackling them will need structural changes to society to give everyone the best chance of a healthy life, free from the impact of dementia. […] At Alzheimer’s Research UK, we want to see the new Public Health and Prevention Minister, Andrew Gwynne MP, establish a prevention strategy that addresses the health and lifestyle factors linked to dementia – from what we eat and drink, to the air we breathe and the education we receive. […] Dementia has devastated too many lives already. It’s vital that we continue finding ways to prevent people from ever developing the condition in the first place.

• #5 Alzheimer’s Disease May Be Preventable | Patient Care

  https://weillcornell.org/news/alzheimer%E2%80%99s-disease-may-be-preventable

  Alzheimers disease can start forming in the brain as early as your 20s or 30s, although the classic symptoms of memory loss typically dont appear until age 65 or older, Dr. Niotis says. […] Although there is no cure for Alzheimers, being physically active, eating nutritiously, limiting alcohol consumption, and not smoking may help reduce the risk. Research has shown that 40% of Alzheimers cases may be preventable based on modifiable risk factors, Dr. Niotis says. […] Exercising at least three hours per week […] Eating a Mediterranean-style diet rich in green leafy vegetables, berries, and fatty fish like wild salmon, mackerel, and albacore tuna […] Reducing bad carbohydrates or empty calories like bread, pasta, rice, sweets […] Minimizing alcohol intake […] Getting adequate amounts of sleep

• #6 Alzheimer’s Prevention Clinic | Patient Care

  https://weillcornell.org/services/neurology/alzheimers-disease-memory-disorders-program/our-services/alzheimers-prevention-clinic

  Alzheimer’s disease (AD) starts in the brain 20 to 30 years before the onset of symptoms, giving physicians ample time to intervene in an individualized fashion for those at risk. […] There is no „magic pill” or „magic cure” for AD treatment or prevention; however, combining a variety of strategies based on strong science and safety may yield the best chance for benefit. […] Our approach is based on a collaborative care model for Alzheimer’s disease, while being firmly grounded in the latest scientific evidence-based therapies. This integrated approach to care aims to provide the most comprehensive therapies for patients with Alzheimer’s disease, mild cognitive impairment due to Alzheimer’s, „preclinical” Alzheimer’s, and patients who are at risk for the disease. […] We use the latest scientific evidence and consider a variety of factors such as current and past medical problems, genetics, and nutritional patterns to tailor therapies for each patient. […] These principles (also referred to as „pharmacogenomics” and „nutrigenomics”) form the core of our APC approach. We emphasize lifestyle and nutritional approaches and collect data to help further the scientific study of the effects of dietary modifications on brain health.

• #7 Alzheimer’s Prevention Strategies | Homeland Security

  https://www.dhs.gov/employee-resources/news/2022/06/28/alzheimers-prevention-strategies

  Alzheimers disease is the most common cause of dementia among older adults. […] Although the cause is still unknown, scientists are learning more every day about Alzheimers disease and what healthy behaviors can be done to reduce your risk and manage this illness. […] Here are some suggestions that will improve your overall health and well-being but may also play a role in reducing risk for Alzheimers disease and age-related cognitive decline: […] Exercise regularly. Physical activity improves thinking, reduces risk of depression and anxiety, and helps you sleep better. […] Engage in social and intellectually stimulating activities. Reading books, making crafts, solving puzzles, engaging in social activities, and playing games can help lower the risk of mild cognitive impairment. […] Control type 2 diabetes. Controlling blood sugar levels can improve the ability to clearly think, learn, and remember.

• #8 Alzheimer’s Disease: Symptoms & Treatment

  https://my.clevelandclinic.org/health/diseases/9164-alzheimers-disease

  Stay mentally active. Play board games, read, do crossword puzzles, play a musical instrument or do other hobbies that challenge your brain to use and learn new skills. […] Stay socially connected. Regularly talk with your loved ones or people in your community. Joining group activities, such as religious services, exercise classes, book clubs or community volunteer work can all help keep your brain engaged. […] Talk to your provider about genetic testing if youre worried about Alzheimers running in your biological family. They can screen you for the genes or genetic changes that may increase your risk of AD.

• #8 Alzheimer’s Disease: Symptoms & Treatment

  https://my.clevelandclinic.org/health/diseases/9164-alzheimers-disease

  There are some Alzheimers risk factors you cant change or control, like your age and genetics. But you may be able to manage other factors to help reduce your risk. Maintaining your overall health can help protect your brain from cognitive decline. You can try to: […] Follow a healthy eating plan. Eating a variety of nutritious foods can help maintain your brain and overall health. Your provider might suggest you follow a specific eating plan like the Mediterranean or DASH diet. […] Get plenty of physical activity. Exercise and physical activities increase blood flow and oxygen to your brain, which may improve your brain cell health. You dont have to be a high-level athlete to stay active. Walking, gardening, riding a bike or any hobby that makes you move your body can be great ways to stay active.

• #9 Evidence-based prevention of Alzheimer’s disease: systematic review and meta-analysis of 243 observational prospective studies and 153 randomised controlled trials | Journal of Neurology, Neurosurgery & Psychiatry

  https://jnnp.bmj.com/content/91/11/1201

  Evidence-based suggestions are proposed, offering clinicians and stakeholders current guidance for the prevention of AD. […] A total of 21 suggestions are proposed based on the consolidated evidence, with Class I suggestions targeting 19 factors: 10 with Level A strong evidence (education, cognitive activity, high body mass index in late life, hyperhomocysteinaemia, depression, stress, diabetes, head trauma, hypertension in midlife and orthostatic hypotension) and 9 with Level B weaker evidence (obesity in midlife, weight loss in late life, physical exercise, smoking, sleep, cerebrovascular disease, frailty, atrial fibrillation and vitamin C). […] Nineteen were regarded as strong suggestions, nine of which were rated with Level A evidence. Nearly two-thirds of these suggestions target vascular risk factors and lifestyle, strengthening the importance of keeping a good vascular condition and maintaining a healthy lifestyle for preventing AD. […] Two factors were not recommended (Class III): oestrogen replacement therapy (Level A) and acetylcholinesterase inhibitors (Level B).

• #10 Alzheimer’s disease prevention: from risk factors to early intervention | Alzheimer’s Research & Therapy | Full Text

  https://alzres.biomedcentral.com/articles/10.1186/s13195-017-0297-z

  Observational studies have identified several modifiable risk factors for AD. Based on a comprehensive systematic review of the evidence related to risk factors for cognitive decline and AD, the US National Institutes of Health highlighted diabetes mellitus, smoking, depression, mental inactivity, physical inactivity and poor diet as being associated with increased risk of cognitive decline, AD, or both. […] It has been estimated that up to a third of AD cases are potentially attributed to these factors and, consequently, could be prevented. […] The fact that a third of AD cases are potentially attributable to modifiable risk factors highlights the potential of risk factor reduction for disease prevention. However, the need for therapeutic strategies for the remaining two-thirds of cases is still urgent.

• #10 Alzheimer’s disease prevention: from risk factors to early intervention | Alzheimer’s Research & Therapy | Full Text

  https://alzres.biomedcentral.com/articles/10.1186/s13195-017-0297-z

  Intervention strategies focused on modifiable risk factors for the disease are becoming a realistic and relevant therapeutic strategy for disease prevention. […] Several intervention studies focused on primary prevention of dementias are currently ongoing, mainly in Europe, with the aim of reducing disease incidence. […] Results from intervention studies highlight the methodological limitations underlying the design and implementation of effective preventive strategies. […] An effective strategy for AD prevention could start with recommendations addressed to the general population (particularly to cognitively healthy subjects older than 50 years) on how to manage lifestyle and cardiovascular risk factors. […] New consensus diagnostic criteria for preclinical AD, together with the identification of at-risk individuals through the use of biomarkers that are altered before clinical decline (i.e. amyloid deposition in the brain), are key for identifying at-risk asymptomatic individuals who are ideal candidates to participate in secondary prevention trials.

• #10 Alzheimer’s disease prevention: from risk factors to early intervention | Alzheimer’s Research & Therapy | Full Text

  https://alzres.biomedcentral.com/articles/10.1186/s13195-017-0297-z

  Secondary prevention trials in asymptomatic participants with preclinical AD who are amyloid positive are already ongoing. […] Ongoing clinical trials in asymptomatic participants with either a positive amyloid biomarker or at increased genetic risk of AD will help ascertain whether secondary prevention initiatives are valid strategies and whether clinical trials of 35 years are sufficient for delaying cognitive decline, and consequently the onset of Alzheimers dementia.

• #11 Can Alzheimer’s Be Prevented? | Alzheimer’s Association

  https://www.alz.org/alzheimers-dementia/research-and-progress/prevention

  Researchers around the globe are exploring how to prevent Alzheimer’s. While Alzheimer’s prevention has no definitive answers at this time, research has shown that we can take action to reduce our risk of developing it. […] Though research is still evolving, evidence is strong that people can reduce their risk by making key lifestyle changes, including participating in regular activity and maintaining good heart health. Based on this research, the Alzheimer’s Association offers 10 Healthy Habits for Your Brain a collection of tips that can reduce the risk of cognitive decline. […] Regular physical exercise may be a beneficial strategy to lower the risk of Alzheimer’s and vascular dementia. Exercise may directly benefit brain cells by increasing blood and oxygen flow in the brain. Because of its known cardiovascular benefits, a medically approved exercise program is a valuable part of any overall wellness plan.

• #11 Can Alzheimer’s Be Prevented? | Alzheimer’s Association

  https://www.alz.org/alzheimers-dementia/research-and-progress/prevention

  Current evidence suggests that heart-healthy eating may also help protect the brain. Heart-healthy eating includes limiting the intake of sugar and saturated fats and making sure to eat plenty of fruits, vegetables, and whole grains. […] A number of studies indicate that maintaining strong social connections and keeping mentally active as we age might lower the risk of cognitive decline and Alzheimer’s. […] While research is not yet conclusive partially due to the need for more large-scale studies in diverse populations certain lifestyle choices, such as physical activity and diet, may help support brain health and prevent Alzheimer’s. Many of these lifestyle changes have been shown to lower the risk of other diseases, like heart disease and diabetes, which have been linked to Alzheimer’s. With few drawbacks and plenty of known benefits, healthy lifestyle choices can improve your health and possibly protect your brain.

• #12 Physical activity and the risk of dementia | Alzheimer’s Society

  https://www.alzheimers.org.uk/about-dementia/managing-the-risk-of-dementia/reduce-your-risk-of-dementia/physical-activity

  Regular physical activity is one of the best things that you can do to reduce your risk of developing dementia. […] A lack of physical exercise is one of the main factors where the evidence is strong enough to show that it increases a persons risk of developing dementia. […] Research has shown that people who take regular exercise may be up to 20% less likely to develop dementia than those who don’t take regular exercise. […] It has been shown that going from being inactive to doing some amount of exercise has the biggest impact. Sustaining physical activity throughout midlife also seems to have the best effect on reducing dementia risk. […] The ones who exercised the least (the bottom 10%) were more than twice as likely to develop Alzheimer’s disease as the ones who exercised the most (the top 10%).

• #13 Prevent or Slow Down Dementia and Alzheimer’s Progression

  https://www.helpguide.org/aging/dementia/preventing-alzheimers-disease

  The more you strengthen each of the seven pillars in your daily life, the longer and stronger your brain will stay working. Youll also be better able to reduce your risk of developing Alzheimers disease and other types of dementia, or delay the onset of more severe symptoms. […] According to the Alzheimers Research and Prevention Foundation, regular physical exercise can reduce your risk of developing Alzheimers disease by up to 50 percent. Whats more, exercise can also slow further deterioration in those who have already started to develop cognitive problems. […] Alzheimers is sometimes described as diabetes of the brain, and a growing body of research suggests a strong link between metabolic disorders and the signal processing systems. By adjusting your eating habits, however, you can help reduce inflammation and protect your brain.

• #14 Prevention is the new treatment for Alzheimer’s disease | News

  https://news.llu.edu/patient-care/prevention-new-treatment-for-alzheimer-s-disease

  Prevention is the new treatment for Alzheimers disease. Two Loma Linda University Health neurologists are on a mission to prevent or reverse Alzheimers disease which affects more than 5 million people in the United States by educating their patients and the community to implement protective factors centered around healthy eating, regular exercise, restful sleep and optimal activities to challenge the mind. Drs. Dean and Ayesha Sherzai, co-directors of the Brain Health and Alzheimers Prevention Program at Loma Linda University Health, encourage many to take control of their lifestyle choices because they play a significant role in their long-term healthcare. The myth has long been that Alzheimers cannot be prevented, treated or even slowed down, Dean says. The truth is it can be prevented, treated and slowed over time. Moderate to strenuous activity alone can reduce the risk of Alzheimers by 40 percent and stroke by 25 percent, Dean says. In addition, the Sherzais say eating a whole-food, plant-based diet can reduce the risk of Alzheimers by 53 percent.

• #14 Prevention is the new treatment for Alzheimer’s disease | News

  https://news.llu.edu/patient-care/prevention-new-treatment-for-alzheimer-s-disease

  According to the Sherzais, your genes dont determine your destiny they merely give researchers a range of when a disease manifests. Identifying an individuals specific risks can shed light on how to change ones health trajectory, Ayesha says. Many of these risk factors include: High cholesterol, Diabetes, Stress, High blood pressure, Poor sleep, Smoking, Alcohol abuse, Obesity, Poor diet (high sugar and high saturated fats). Individuals who are prone to these risk factors ultimately may experience inflammation, glucose dysregulation, lipid dysregulation and oxidation, Dean says. The Sherzais say the ultimate goal is to overcome these factors and integrate a healthier, more protective lifestyle rich in: Regular exercise, Stress management, Continued learning, Purpose-driven activities, A whole food, plant-based diet, Social engagement, 7-8 hours of restorative sleep.

• #14 Prevention is the new treatment for Alzheimer’s disease | News

  https://news.llu.edu/patient-care/prevention-new-treatment-for-alzheimer-s-disease

  Many of these lifestyle changes are integrated with the Sherzais comprehensive NEURO (Nutrition, Exercise, Unwind, Rest, Optimize) program that enables individuals to focus on healthy habits to strengthen the brain. Patients are encouraged to stay active in all steps of the NEURO program because each part plays an integral role to ones health, Ayesha says. Sleep cleanses the brain of bad proteins and other waste, Ayesha says. According to the Sherzais, sleep apnea can increase the risk of Alzheimers by 70 percent. […] Theres more to just eating healthy and exercising regularly that will help an individual avoid the risk of Alzheimers, Dean says. We tell our patients its important to also identify good versus bad stress, in addition, to participating in challenging, complex activities to stimulate the brain. A lack of mental stimulation increases the risk of Alzheimers, Dean says. Complex activities include dancing, learning a language or playing an instrument. […] The goal is to prevent any other diagnosis or death from Alzheimers, with the help of personalized lifestyle programs in the near future.

• #15 Preventing Alzheimer’s Disease: What Do We Know? | National Institute on Aging

  https://www.nia.nih.gov/health/alzheimers-and-dementia/preventing-alzheimers-disease-what-do-we-know

  Controlling high blood pressure is known to reduce a person’s risk for heart disease and stroke, and it also might help prevent or delay Alzheimer’s. High blood pressure, particularly in midlife, is considered a risk factor for later-life cognitive decline. […] While research continues, experts recommend that people control high blood pressure to lower their risk of other serious health problems. […] The NASEM review of research did not find enough evidence to recommend a certain diet, but some healthy eating patterns and diets have been associated with cognitive benefits. […] Years of animal and human observational studies suggest that exercise may help with brain health and cognitive performance, or how well you think, learn, and remember. […] While there is not enough evidence from clinical trials to conclude that exercise can prevent or slow MCI or Alzheimers, some studies suggest that it may help delay or slow age-related cognitive decline.

• #15 Preventing Alzheimer’s Disease: What Do We Know? | National Institute on Aging

  https://www.nia.nih.gov/health/alzheimers-and-dementia/preventing-alzheimers-disease-what-do-we-know

  Researchers continue to explore physical activity as a possible way to help prevent or delay Alzheimers. […] Hearing loss has been linked to greater risk of developing dementia. […] There is evidence suggesting cognitive training may help delay or slow age-related cognitive decline. […] Many studies are ongoing to explore cognitive training as a possible way to prevent cognitive decline and dementia. […] In the meantime, generally leading a healthy lifestyle, including controlling high blood pressure, being physically active, and making healthy dietary choices, will help reduce your risk of many chronic health conditions and may help reduce your risk of dementia. […] Researchers cant say for certain whether making healthy lifestyle changes will protect against dementia, but taking these steps may help reduce your risk.

• #16 Alzheimer’s Disease Prevention Strategies

  https://www.verywellhealth.com/alzheimers-prevention-4014142

  Alzheimers disease prevention focuses on identifying and modifying the lifestyle factors that increase your risk for dementia. […] As you improve the health variables that contribute to Alzheimers disease, you may lower your risk of developing dementia. These include high blood pressure, heart disease, high blood sugar and diabetes, and poor diet, among others. […] Keeping your heart healthy also lowers the risk of Alzheimer’s disease because many of the same strategies to reduce heart disease benefit your brain. […] Physical exercise is strongly correlated with a reduced risk of developing Alzheimer’s and other types of dementia. […] Studies also show that activities like running, weight resistance training, and yoga may reduce your risk of dementia. […] People following the Mediterranean or MIND (Mediterranean-DASH Intervention for Neurodegenerative Delay) diets, which are based on the foods listed above, may have a 35% to 53% lower risk of developing Alzheimer’s disease.

• #16 Alzheimer’s Disease Prevention Strategies

  https://www.verywellhealth.com/alzheimers-prevention-4014142

  Research suggests that smoking can affect your brain and memory. […] The results, published in the Journal of Alzheimer’s Disease in 2025, found that people who smoked had a 1.3 times higher odds of developing dementia. […] Obesity is linked to a higher risk for Alzheimers disease. […] The link between high blood sugar and dementia risk is so profound that Alzheimer’s disease has been nicknamed „type 3 diabetes.” […] Keeping blood sugar within the healthy range (using diet, exercise, and medication when needed) can prevent insulin resistance and type 2 diabetes. […] Mental activity has been associated with increased cognitive reserve, which refers to the brain’s resilience and ability to think and function as you age. […] Spending time with friends is essential for maintaining quality of life and improving mental well-being.

• #16 Alzheimer’s Disease Prevention Strategies

  https://www.verywellhealth.com/alzheimers-prevention-4014142

  There is a connection between head injuries (traumatic brain injuries), especially those where you lose consciousness, and an increased risk of dementia and Alzheimer’s disease. […] Studies show that the brains nightly maintenance reduces levels of amyloid and tau proteins. […] The link between sleep quality and increased amyloid is so strong that the quality of your sleep may help predict the chances of developing Alzheimers disease. […] The connection between alcohol and Alzheimer’s disease is still being studied. […] Identifying risk factors and taking steps to change them is the best, and currently, the only way to prevent Alzheimer’s disease. […] Protecting your overall health also helps prevent Alzheimer’s disease.

• #17 Prevention of dementia – Wikipedia

  https://en.wikipedia.org/wiki/Prevention_of_dementia

  An active lifestyle can almost halve the risk compared to a sedentary one. […] Regular exercise can boost BDNF levels by 23 times. […] Obesity increases the risk of any dementia and Alzheimer’s disease in particular. […] Moderate alcohol consumption can possibly reduce the risk of vascular disease and dementia because it can increase blood levels of HDL cholesterol and weakens blood-clotting agents such as fibrinogen, which offers some protection against heart attacks and small subclinical strokes that together can ultimately damage the brain. […] Niacin (vitamin B3) is also believed to prevent dementia as research shows those who have the highest levels of niacin in their blood, are believed to have the lowest risk of developing dementia or having cognitive decline. […] Vitamin D deficiency correlates with cognitive impairment and dementia; however, the value of vitamin D substitution in cognitive impairment remains doubtful.

• #17 Prevention of dementia – Wikipedia

  https://en.wikipedia.org/wiki/Prevention_of_dementia

  Lack of sleep may also increase risk of dementia by increasing beta-amyloid deposition. […] There is some evidence that late-life depression increases the risk of dementia however suggesting treating depression in mid-life might delay or prevent dementia. […] Lowering blood pressure with antihypertensives may have a positive effect in the prevention of dementia, just as physical activity. […] Diabetes mellitus is a risk factor for dementia, and thus the risk of dementia is lowered with anti-diabetic drugs. […] Estrogen may play a role in the prevention of dementia. […] Non-steroidal anti-inflammatory drugs (NSAIDs) can decrease the risk of developing Alzheimer’s and Parkinson’s diseases. […] There is as yet no vaccine against dementia. […] Suggestions to reduce the 'anticholinergic burden’, try to modify a person’s medications to reduce the use of medications that have anticholinergic activity in a safe way, are often made in dementia guidelines with the goal of improving cognition and/or reducing further decline.

• #18 How Exercise Reduces Risk of Alzheimer’s Disease | Cognitive Enhancement

  https://longevity.stanford.edu/lifestyle/2024/05/28/how-exercise-reduces-risk-of-alzheimers-disease/

  Alzheimer’s disease (AD) is one of the most devastating illnesses among older adults. […] Even though scientists are working toward curing AD, we can take preventative measures by incorporating healthy habits, such as regular exercise, into our routine. […] “Therefore, we should do everything in our power to incorporate healthy lifestyle habits as early as possible.” […] Several research studies have concluded that physical activity is one of the best ways to reduce risk significantly. […] Exercise stands out as one of the most effective strategies for prevention, offering a low-cost, non-pharmacological, and low-risk option accessible to everyone. […] Dr. Khemani recommends incorporating sprint intervals into our workouts. “We encourage our patients to engage in moderate-intensity exercises incorporating some high-intensity interval training, if possible, as these activities have been shown to be more impactful for Alzheimer’s prevention than light exercise alone,” she says.

• #19 Diet in the Prevention of Alzheimer’s Disease: Current Knowledge and Future Research Requirements

  https://www.mdpi.com/2072-6643/14/21/4564

  Alzheimer’s disease is a progressive brain disease that is becoming a major health problem in today’s world due to the aging population. Despite it being widely known that diet has a significant impact on the prevention and progression of Alzheimer’s disease, the literature data are still scarce and controversial. The application of the principles of rational nutrition for the elderly is suggested for Alzheimer’s disease. The diet should be rich in neuroprotective nutrients, i.e., antioxidants, B vitamins, and polyunsaturated fatty acids. Some studies suggest that diets such as the Mediterranean diet, the DASH (Dietary Approaches to Stop Hypertension) diet, and the MIND (Mediterranean-DASH Intervention for Neurodegenerative Delay) diet have a beneficial effect on the risk of developing Alzheimer’s disease.

• #20 What can you do to prevent Alzheimer’s disease if you have the APOE4 genetic risk factor? | Cognitive Vitality | Alzheimer’s Drug Discovery Foundation

  https://www.alzdiscovery.org/cognitive-vitality/blog/what-can-you-do-to-prevent-alzheimers-disease-if-you-have-the-apoe4-genetic-risk-factor

  The 2020 Lancet Commission on Dementia Prevention, Intervention and Care reported that fully addressing 12 lifestyle risk factors can prevent or delay up to 40% of dementia cases. […] The Mediterranean diet is inspired by the dietary habits of Greece, Southern Italy, and Spain, and is high in fresh fruits, vegetables, fish, olive oil, and nuts. A systematic review of studies examining the relationship between this diet and cognitive health concluded that higher adherence to the Mediterranean diet is associated with up to a 33% lower risk of developing mild cognitive impairment and Alzheimer’s disease. […] In a comprehensive review of dementia prevention strategies, a low-carbohydrate diet or a low-glycemic index diet is recommended for people with the APOE4 variant. […] Getting sufficient levels of DHA is thought to be an important consideration for preventing Alzheimer’s disease.

• #20 What can you do to prevent Alzheimer’s disease if you have the APOE4 genetic risk factor? | Cognitive Vitality | Alzheimer’s Drug Discovery Foundation

  https://www.alzdiscovery.org/cognitive-vitality/blog/what-can-you-do-to-prevent-alzheimers-disease-if-you-have-the-apoe4-genetic-risk-factor

  Therefore, limiting alcohol consumption is recommended for people with the APOE4 variant. […] Several studies have demonstrated that people with APOE4 respond more positively to exercise than people without APOE4. […] Thus, increasing physical activity, while important for everyone, may have more pronounced benefits in people with APOE4. […] Therefore, managing high blood pressure may be particularly important for people with APOE4. […] One observational study reported that cholesterol-lowering statins may provide greater benefits with regards to cognitive function and dementia risk in people who have two copies of the APOE4 variant compared to people with zero or one copy of APOE4. […] Lifelong learning is associated with good cognitive health, and higher levels of cognitive activity at mid- or late-life are linked to higher levels of cognitive functions and lower risk of Alzheimers disease. […] Evidence from observational studies have reported that lack of sleep is associated with cognitive decline and higher risk of dementia. […] As outlined above, there are concrete steps you can take to reduce the risk of Alzheimers disease or delay its onset, regardless of genetic risk factors.

• #21 What to eat to reduce your risk of Alzheimer’s disease – Harvard Health

  https://www.health.harvard.edu/blog/what-to-eat-to-reduce-your-risk-of-alzheimers-disease-2020050819774

  Would you like reduce your risk of cognitive impairment, Alzheimers disease, and dementia? […] One factor that a number of studies have converged on is a Mediterranean-style diet. […] To reduce your risk of cognitive impairment and decline, eat a Mediterranean-style diet including fish several times per week. […] Fish was the single most important dietary factor in lowering the risk of cognitive impairment. […] Eating fish lowered the risk of both cognitive impairment and cognitive decline.

• #22 New MIND Diet May Significantly Protect Against Alzheimer’s Disease | Rush

  https://www.rush.edu/news/new-mind-diet-may-significantly-protect-against-alzheimers-disease

  A new diet, appropriately known by the acronym MIND, could significantly lower a persons risk of developing Alzheimers disease, even if the diet is not meticulously followed, according to a paper published online for subscribers in March in the journal Alzheimers Dementia: The Journal of the Alzheimers Association. […] The study shows that the MIND diet lowered the risk of AD by as much as 53 percent in participants who adhered to the diet rigorously, and by about 35 percent in those who followed it moderately well. […] One of the more exciting things about this is that people who adhered even moderately to the MIND diet had a reduction in their risk for AD, said Morris, a Rush professor, assistant provost for Community Research, and director of Nutrition and Nutritional Epidemiology. […] This is the first study to relate the MIND diet to Alzheimers disease.

• #22 New MIND Diet May Significantly Protect Against Alzheimer’s Disease | Rush

  https://www.rush.edu/news/new-mind-diet-may-significantly-protect-against-alzheimers-disease

  The MIND diet includes at least three servings of whole grains, a salad and one other vegetable every day along with a glass of wine. […] Dieters must limit eating the designated unhealthy foods, especially butter (less than 1 tablespoon a day), cheese, and fried or fast food (less than a serving a week for any of the three), to have a real shot at avoiding the devastating effects of Alzheimer’s, according to the study. […] Past studies have yielded evidence that suggests that what we eat may play a significant role in determining who gets AD and who doesnt, Morris said. […] That probably means that people who eat this diet consistently over the years get the best protection. […] In other words, it looks like the longer a person eats the MIND diet, the less risk that person will have of developing AD, Morris said. […] The results need to be confirmed by other investigators in different populations and also through randomized trials. That is the best way to establish a cause-and-effect relationship between the MIND diet and reductions in the incidence of Alzheimers disease, she said.

• #23 Prevention | Alzheimer’s Disease Research Center

  http://www.adrc.wisc.edu/prevention

  Alzheimers disease affects people across economic, educational, social, racial, and gender lines. Currently, there is no cure for Alzheimers disease, placing a lot of importance on Alzheimer’s disease prevention. Scientists have found evidence that some lifestyle changes can delay the onset or lower risk for the disease. […] To help keep your mind healthy, follow these six evidence-based lifestyle recommendations we call the 6 Brain Health Pillars to Build a Brain Buffer. […] Physical activity and exercise offer a host of benefits throughout the body, including in the brain. […] In general, healthy seniors should try to get 30 minutes of moderate intensity exercise five days a week. […] A study of nearly 1,000 people who followed the MIND diet found those who closely followed the diet reduced their risk of developing Alzheimers disease by 53 percent.

• #23 Prevention | Alzheimer’s Disease Research Center

  http://www.adrc.wisc.edu/prevention

  Sleep is essential to healthy living. […] Aim for 7 to 9 hours of restorative sleep each night, prioritize sleep, and start a relaxing evening routine that includes dim lights (but not smartphones, TVs, or other screens) and peaceful thoughts. […] Social engagement is an important factor in the prevention of Alzheimers disease and dementia itself. […] Studies have shown people with regular social contact are less likely to get dementia and that social interaction may even help delay the progression of dementia. […] Cognitive enrichment is keeping your mind active. […] Studies have shown participation in a range of mentally and socially engaging activities in midlife reduces the risk for Alzheimers disease and dementia. […] Chronic stress can have long-term effects on the brain, so managing stress is an important factor in overall brain health.

• #23 Prevention | Alzheimer’s Disease Research Center

  http://www.adrc.wisc.edu/prevention

  While the link between stressful life experiences and cognition is still being explored, it is worth noting that stress is a controllable risk factor; unlike our genes that cannot be changed, there are ways to reduce stress in life and ultimately improve your mental health and possibly alter trajectories for Alzheimers disease. […] One of the best ways of managing stress is by practicing mindfulness. […] UW Health offers additional information about strategies people can follow to reduce their risk or delay symptoms of dementia.

• #24 Alzheimer’s Disease Prevention | BrightFocus Foundation

  https://www.brightfocus.org/alzheimers/prevention/

  Alzheimers disease is a complex disorder for which there is currently no known prevention or cure. However, research suggests that lifestyle choices can support healthy brain aging and reduce Alzheimers disease risk. Healthy habits, like exercising and eating a nutrient-rich diet, can improve and maintain overall health. […] Some research has generated hope that one day it might be possible to slow the progression of Alzheimers disease, delay its symptoms, or even prevent it from occurring at all. Although research supports the benefit of some interventions such as physical activity and cardiovascular risk reduction nothing at this time has definitively been shown to prevent Alzheimers disease or other dementias. […] Eat a varied, nutritious, and low-glycemic diet. […] Get regular exercise and maintain a healthy weight.

• #24 Alzheimer’s Disease Prevention | BrightFocus Foundation

  https://www.brightfocus.org/alzheimers/prevention/

  Keep your mind active. […] Get enough good quality sleep, as recommended for your age group. […] Smoking is an established risk factor for cognitive decline, which may be reduced significantly by smoking cessation. […] Although a moderate level of alcohol consumption is a recognized component of the healthy Mediterranean and MIND diet plans, too much is unhealthy for the brain. […] Studies have linked mid-life hypertension with cognitive decline, a risk that is reduced with an appropriate treatment regimen. […] Some scientists call Alzheimers the diabetes of the brain because of its biological ties to diabetes. Eating a healthy, balanced diet can help manage this risk in many cases. […] Emerging studies have linked hearing loss with age as a potential risk factor for cognitive decline, which can be reduced by preventing or correcting hearing loss.

• #24 Alzheimer’s Disease Prevention | BrightFocus Foundation

  https://www.brightfocus.org/alzheimers/prevention/

  Your brain and body need a consistent, healthy sleep schedule to stay in rhythm, get rid of waste, and more. Some sleep disorders, like sleep apnea, are thought to increase the risk for cognitive decline. […] Research links loneliness with faster cognitive decline. Previous research, too, has linked the damaging effects of social isolation on health and supports healing effects of social engagement. […] Join us as lead scientist Dr. Miia Kivipelto discusses the science behind lifestyle interventions for reducing Alzheimers risk.

• #25 Prevent Alzheimer’s Disease – Pillar 1: Diet and Supplements

  https://alzheimersprevention.org/4-pillars-of-prevention/pillar-1-diet-supplements/

  Your diet is critical to your brains health. […] With the proper Alzheimers diet, you can actually influence the health of your genes. […] One of the best ways you can feed your brain for better memory is by avoiding a diet high in trans-fat and saturated fat. […] Eating foods that are high in antioxidants like vitamins C and E is a wonderful natural way to eliminate free radicals from your body. […] Scientists believe that a vast intake of fruits and vegetables, eating fish rich in omega-3 oils and vegetarian protein substitutes (such as soy) are protective against memory loss. […] The ideal prevention diet breaks down like this: 20% good fats. Items in this group include extra virgin olive oil, avocado, and flax seed oil; 40% lean proteins. Look to include fish, chicken, turkey, and soy on a daily basis; 40% complex carbohydrates. Discover the rewards of a rainbow of fresh vegetables, whole grains, legumes, and fresh fruits; Superfoods for the brain as much as you want! These superfoods, including blueberries, spinach, and seaweed, have fabulous antioxidant properties preventing causes of Alzheimers.

• #25 Prevent Alzheimer’s Disease – Pillar 1: Diet and Supplements

  https://alzheimersprevention.org/4-pillars-of-prevention/pillar-1-diet-supplements/

  If youre serious about the prevention of Alzheimers and improving memory loss, you should definitely take a high potency multiple vitamin and mineral capsule. […] Folic acid reduces homocysteine levelshigh homocysteine levels put you at risk for both heart disease and memory loss. […] Vitamin C has been shown to reduce your risk of Alzheimers disease by 20% when taken with vitamin E. […] To take advantage of its fullest benefits, you should take a dose of 2,000 mg of vitamin C per day. […] Consider including the following memory-specific nutrients in your daily vitamin plan: coenzyme Q10, alpha lipoic acid, ginkgo biloba, phosphatidylserine, Omega-3s, acetyl-L-carnitine. […] Two additional nutrients are recommended only for people who have moderate to severe memory loss: huperzine-A, vinpocetine.

• #26 Alzheimer’s Disease – key nutrition and lifestyle factors

  https://foodforthebrain.org/campaigns/alzheimers-prevention/preventing-alzheimers/

  It certainly makes sense to test your homocysteine level and if it is above 9mmol/l to ensure an optimal intake of B6, B12 and folic acid. […] Omega-3 fats are most prevalent in carnivorous, cold water fish such as salmon, tuna, herring and mackerel. […] A randomized, double-blind, placebo-controlled, clinical study, gave 900mg of DHA a day for 24 weeks and reported an improvement in learning and memory function in those with age-related cognitive decline. […] These studies suggest that DHA may help prevent cognitive decline before the development of Alzheimers, but dont help arrest or slow down Alzheimers per se. […] Vitamin E appears to have a protective effect. […] A study published in the Journal of the American Medical Association (JAMA) found that the risk of developing Alzheimers was 67 per cent lower in those with a high dietary intake of vitamin E, versus those with a low intake. […] All this research implies that the ability to create a lifestyle that minimises prolonged stress is also important for reducing Alzheimers risk.

• #26 Alzheimer’s Disease – key nutrition and lifestyle factors

  https://foodforthebrain.org/campaigns/alzheimers-prevention/preventing-alzheimers/

  Thats the bad news. The good news is that a number of encouraging research avenues indicate that dementia and Alzheimers could be prevented, and possibly halted in the early stages by a comprehensive optimum nutrition approach. […] Current research is focusing on how to encourage not only neurone growth, but also how to enhance the formation of new dendrite connections. But the most exciting frontier is improving your nutrition to prevent memory decline in the first place. […] The strongest evidence to date relates to raised homocysteine levels, which both predicts risk and can cause the kind of brain damage seen in Alzheimers, caused by lack of B vitamins, especially B12 which is increasingly poorly absorbed with age. […] To date, the evidence suggests that, in those with raised homocysteine supplementing something in the order of 1,000mcg of folic acid, 20mg of B6 and 500mcg of B12, can help prevent age-related memory loss and brain shrinkage and may even help those in the early stages of Alzheimers disease.

• #27 Alzheimer’s, Omega 3 & B Vitamins | Food for the Brain

  https://foodforthebrain.org/campaigns/alzheimers-prevention/omega-3-and-b-vitamins/

  Of all these disease-modifiable risk factors for Alzheimers dementia the top two, right now, are homocysteine lowering B vitamins and omega-3 or seafood intake. […] Fish, especially cold-water oily fish, contain high levels of EPA and DHA and epidemiological studies consistently show that an elevated fish intake is associated with decreased risk of neurodegenerative diseases such as Alzheimers disease. […] DHA supplementation appears to show the greatest promise, particularly in the early stage before the onset of memory loss symptoms, and at levels at or above 1000 mg per day. […] These studies suggest that DHA may help prevent cognitive decline before the development of Alzheimers, but dont help arrest or slow down Alzheimers per se. […] B vitamins, especially vitamin B6, folate (found in greens) and vitamin B12, which is only found in animal produce, are essential for a process called methylation.

• #27 Alzheimer’s, Omega 3 & B Vitamins | Food for the Brain

  https://foodforthebrain.org/campaigns/alzheimers-prevention/omega-3-and-b-vitamins/

  Homocysteine, above 11mcmol/l, is perhaps the best blood marker of Alzheimers risk being found in the brains of those with Alzheimers. […] This finding led another trial called B-proof that had tested the effects of B vitamins on cognitive function in adults over 65 with high homocysteine and found only modest reduction in the rate of decline of global cognition to test the omega-3 status of the participants from frozen blood samples they had taken at the start of the trial to investigate whether those with higher omega-3 blood levels had more improvement in cognition. […] This discovery, now shown in two trials, that having enough omega-3 DHA enhances the effect of B vitamins and that B vitamins are less effective in the people with low omega-3 DHA, makes complete sense of what we know about how the critical membrane of neurons (brain cells) are made. […] In other words, you cannot build brain cells without both sufficient omega-3 DHA and sufficient B vitamins to ensure that the process of methylation, which binds the DHA into the membrane structure, is working efficiently.

• #28 Alzheimer’s Disease

  https://www.pcrm.org/health-topics/alzheimers

  Plant-based foods are beneficial to the brain and may help prevent Alzheimers disease and other forms of dementia. […] Instead, eat a plant-based diet rich in fiber, fruits, and vegetables, which helps protect brain health. Populations that have higher intakes of plant-based foods have a reduced risk for Alzheimers disease. […] Foods rich in vitamin E including nuts, seeds, leafy greens, and whole grains are especially beneficial for brain health. Increasing vitamin E intake from foods is associated with a decreased risk of developing Alzheimer’s disease. […] Vitamin D deficiency is associated with a large increased risk of dementia and Alzheimer’s disease. […] Avoiding dairy, meats, oils, snack pastries, and fried foods can reduce Alzheimer’s risk. […] A diet rich in fruits, vegetables, legumes, and grains may protect against Alzheimers risk factors.

• #29 Alzheimer’s Prevention Diet: 11 Tasty Foods that Reduce Dementia Risk | Denver Health Medical Plan

  https://www.denverhealthmedicalplan.org/blog/alzheimers-prevention-diet-11-tasty-foods-reduce-dementia-risk

  Some risks for developing Alzheimer’s and dementia are out of our control, but our diet is a prevention method we can control. […] When we take the time to watch what we eat and care for our overall health, we give ourselves and our loved ones a gift the gift of caring about ourselves and the time we have. […] Eating strawberries, blueberries and acai fruit appears to counteract some of the declines in cognition that were noticed in research related to poor diet. […] Both caffeine in general and coffee specifically have been associated with cognitive benefits, including a significantly lower risk of progression from mild cognitive impairment to dementia. […] Apple juice was shown in research to reverse memory loss in mice caused by a deficient diet, as well as protect their brains from the hallmark buildup of beta amyloid protein that is present in Alzheimer’s disease.

• #29 Alzheimer’s Prevention Diet: 11 Tasty Foods that Reduce Dementia Risk | Denver Health Medical Plan

  https://www.denverhealthmedicalplan.org/blog/alzheimers-prevention-diet-11-tasty-foods-reduce-dementia-risk

  Several studies have connected nut consumption to a lower risk of dementia. […] Multiple studies have associated cocoa and dark chocolate with a lower chance of cognitive decline. […] Multiple research studies demonstrated a cognitive benefit for those who drank light to moderate amounts of alcohol. […] The omega-3-fatty acids found in certain types of fish have been touted as great for your brain health, and most research conducted on this has agreed. […] Multiple studies have demonstrated that cinnamon, when given to mice, was correlated with an improvement in the ability to clear the buildup of protein in the brain that’s connected with Alzheimer’s disease, as well as improve memory and other cognitive functioning. […] Curcumin has been demonstrated to be highly correlated with both preventing cognitive decline and treating dementia already present in mice.

• #30 Reduce your risk of dementia | Alzheimer’s Society

  https://www.alzheimers.org.uk/about-dementia/managing-the-risk-of-dementia/reduce-your-risk-of-dementia

  There are things you can do to reduce your own risk of developing dementia. These include keeping active, eating healthily and exercising your mind. […] No single behaviour is guaranteed to prevent dementia, and some are more easy to change than others. […] Doing regular physical activity is one of the best ways to reduce your risk of dementia. […] Drinking too much alcohol increases your risk of developing dementia. […] If you smoke, you’re putting yourself at a much higher risk of developing dementia later in life. […] People who have had periods of depression in their life also have a higher risk of developing dementia. […] Social isolation can greatly increase a person’s risk of dementia. […] Certain health conditions, such as high blood pressure, high cholesterol or diabetes can increase the risk of getting dementia.

• #30 Reduce your risk of dementia | Alzheimer’s Society

  https://www.alzheimers.org.uk/about-dementia/managing-the-risk-of-dementia/reduce-your-risk-of-dementia

  Uncorrected vision loss increases a person’s risk of developing dementia. […] Hearing loss is related to an increased risk of developing dementia and may be an early symptom. […] Traumatic brain injuries are caused by a blow or jolt to the head especially when the person is knocked out unconscious. These can start a process in the brain where the substances that cause Alzheimer’s disease build up around the injured area. […] Certain forms of air pollution increase a person’s risk of dementia.

• #31 Lifestyle Empowerment for Alzheimer’s Prevention (LEAP!)

  https://www.kumc.edu/research/alzheimers-disease-research-center/community-outreach/lifestyle-empowerment-for-alzheimers-prevention.html

  A balanced eating pattern such as a Mediterranean-style diet provides key nutrients your brain needs to thrive. […] Challenging your mind and spending time with others helps keep your brain adaptable and resilient. […] Sleep helps the brain consolidate memories and get rid of toxins. Long-term sleep loss may increase your risk of several brain health conditions. […] While everyone experiences stressful situations from time to time, chronic stress may harm the brain. Tools and techniques like breathing exercises, meditation, or art can help protect our brain health as we face lifes challenges. […] LEAP! provides free and low-cost online programs that will equip you with science-based strategies to support your brain health.

• #32 Alzheimer’s disease prevention includes lifestyle choices | Opinion

  https://www.palmbeachpost.com/story/opinion/columns/2025/01/10/alzheimers-disease-dementia-prevention-diet-exercise/77432025007/

  A Mediterranean-style diet, regular exercise, and weight loss help to prevent or reverse both type 2 diabetes and high blood pressure. […] Other protective lifestyle strategies include: addressing vision and hearing loss, getting 7-8 hours of sleep with about 1.5-2 hours in deep sleep or dream states, staying socially active, responding to stress in ways that are calming, learning new skills or new types of puzzles, reading about new and challenging topics, maintaining dental health, protecting from head injury by wearing car seat belts, helmets for activities such as biking, and avoiding or limiting alcohol. […] Additionally, finding moments of quiet with deep, slow breathing, creating a meditative state, is believed to strengthen the areas of the brain involved in learning and memory and help with responding to stress in a healthier way.

• #33 Evidence-Based Prevention – Alzheimer’s Disease Research Center

  http://depts.washington.edu/mbwc/adrc/page/prevention

  2020 findings from the SPRINT-MIND study found that lowering blood pressure to under 120 showed a 19% reduction in those participants who went on to develop dementia during the study. […] In terms of brain and cognitive health, the best data support the Mediterranean diet, which includes relatively little red meat and emphasizes whole grains, fruits and vegetables, fish and shellfish, and nuts, olive oil and other healthy fats. […] A study published in Alzheimer’s Dementia of 923 adults aged 58-98 who maintained the MIND diet for 4.5 years showed a 53% reduction in the incidence of Alzheimer’s disease dementia. […] An NIH-funded study found that eating a Mediterranean diet slows some changes in the brain that may indicate early Alzheimer’s disease. […] According to UW MBWC’s Dr. Kristoffer Rhoads mindfulness meditation can boost memory and improve brain connections in people with mild cognitive impairment (MCI) and early stage dementia.

• #34 Alzheimer’s prevention: Does it exist?

  https://www.mayoclinic.org/diseases-conditions/alzheimers-disease/expert-answers/alzheimers-prevention/faq-20058140

  Not yet. But there’s strong evidence that healthy lifestyle habits such as diet, exercise and not smoking may play a role in reducing your risk of Alzheimer’s disease and other types of dementia. […] In particular, the Mediterranean diet has been associated with a reduced risk of Alzheimer’s disease and dementia. […] More research is needed before experts know specific ways to prevent Alzheimer’s. But here are some steps that promote good overall brain health: Avoid smoking. Control vascular risk factors, including high blood pressure, high cholesterol and diabetes. Lower your low-density lipoprotein (LDL) cholesterol levels if they’re high. Do this with treatment recommended by your healthcare professional and lifestyle changes such as exercising and eating a healthy diet. Eat a balanced diet such as the Mediterranean diet that’s rich in vegetables, fruits and lean protein, particularly protein sources containing omega-3 fatty acids. Be physically and socially active, including engaging in aerobic exercise. Maintain a healthy weight. Take care of your mental health. Use thinking (cognitive) skills, such as memory skills. Avoid head injury. Treat hearing loss. Treat vision loss. Limit alcohol consumption.

• #35 Alzheimer’s disease – Symptoms and causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/alzheimers-disease/symptoms-causes/syc-20350447

  Alzheimer’s disease can’t be prevented. But making lifestyle changes can lower your risk of getting the disease. […] Research suggests that taking steps that lower your risk of cardiovascular disease may reduce the risk of dementia, as well. To follow heart-healthy lifestyle choices that may lower the risk of dementia: Exercise regularly. Eat a diet of fresh produce, healthy oils and foods low in saturated fat, such as a Mediterranean diet. Work with your healthcare professional to manage high blood pressure, diabetes and high cholesterol. Pay particular attention to your levels of low-density lipoprotein, known as LDL, cholesterol. High levels of LDL cholesterol in people younger than 65 raises the risk of dementia. But taking medicines to lower LDL cholesterol doesn’t raise the risk. […] One large, long-term study done in Finland found that making lifestyle changes helped reduce cognitive decline among people who were at risk of dementia. Those in the study were given individual and group sessions that focused on diet, exercise and social activities.

• #35 Alzheimer’s disease – Symptoms and causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/alzheimers-disease/symptoms-causes/syc-20350447

  Several studies have found that following a Mediterranean diet leads to better cognitive function and a slower cognitive decline with age. A Mediterranean diet focuses on plant-based foods such as fruits, vegetables, grains, fish, poultry, nuts and olive oil. The diet includes less foods that are high in saturated fats and trans fats, such as butter, margarine, cheese, red meat, fried food and pastries. […] It’s also important to treat vision loss and hearing loss. Studies have found that vision loss that isn’t treated is a risk factor for cognitive impairment and dementia. Studies also have found that people who have hearing loss are at higher risk of dementia. But wearing hearing aids made people less likely to get dementia. […] Other studies have shown that staying engaged mentally and socially is linked to preserved thinking skills later in life and a lower risk of Alzheimer’s disease. This includes going to social events, reading, dancing, playing board games, creating art, playing an instrument and other activities.

• #36 Can You Prevent Alzheimer’s Disease?

  https://health.clevelandclinic.org/how-to-prevent-alzheimers-disease

  High levels of low-density lipoprotein (LDL), often referred to as the bad cholesterol, can cause fatty deposits to build up within blood vessels. Studies show that elevated LDL levels can be a risk factor for Alzheimers, as well as other health conditions. […] High blood pressure (hypertension) can affect the blood flow needed for parts of your brain to function. […] Diabetes is also connected to previously mentioned risk factors such as high cholesterol and high blood pressure. […] Head injuries (such as a concussion) at any age increase your risk for Alzheimers later in life. […] People who smoke are 40% more likely to develop Alzheimers disease, research shows. […] If you stop smoking you can eventually erase any increased risk of dementia or Alzheimers from the habit. […] But over the long term, alcohol can damage your brain when consumed in excess, says Dr. Caldwell. […] If youre worried about developing dementia or Alzheimers, know that there are steps you can take to protect yourself. […] Even if there are some things we cant control, theres a lot we can do to reduce risk, reinforces Dr. Caldwell. Making changes can make a difference.

• #37 Treating high blood pressure to prevent Alzheimer’s disease | Centre for Healthy Brain Ageing (CHeBA)

  https://www.cheba.unsw.edu.au/news/treating-high-blood-pressure-prevent-alzheimers-disease

  New research from the Centre for Healthy Brain Ageing (CHeBA) suggests that high blood pressure treatment should be part of Alzheimers disease prevention strategies. […] The findings of this study suggest that antihypertensive use should be part of any Alzheimers disease prevention strategy throughout later life. […] Treating this often silent but deadly illness will be crucial in tackling the pressing crisis we are seeing with increasing rates of dementia.

• #38

  https://link.springer.com/article/10.14283/jpad.2023.113

  Metformin is a safe and effective medication for Type 2 diabetes (T2D) that has been proposed to decrease the risk of aging related disorders including Alzheimers Disease (AD) and AD related disorders (ADRD). […] Studies in animal models suggest that metformin could decrease the risk of AD/ADRD through multiple mechanisms including neuroprotective effects, decreasing neuroinflammation, and decreasing AD pathology. […] Observational human studies are also conflicting, but those with better study designs suggest that metformin use in persons with T2D is associated with a lower risk of dementia. […] There are few clinical trials in persons without T2D that have small sample sizes and short durations but suggest that metformin could prevent AD/ADRD. […] There are ongoing studies including large clinical trials with long duration that are testing the effect of metformin on AD/ADRD outcomes in persons without T2D at risk for dementia.

• #39 Science Reveals 4 New Ways to Lower Your Dementia Risk

  https://www.webmd.com/alzheimers/news/20250505/science-reveals-4-new-ways-to-lower-your-dementia-risk

  Quality sleep has long been linked with reduced dementia risk not to mention improvements in mood, immunity, blood sugar, heart health, and weight. But a new study zeroes in on the right kind of sleep for Alzheimer’s prevention. […] Not getting enough deep sleep and REM sleep, especially in midlife, is related to shrinkage in a part of the brain that’s particularly vulnerable in Alzheimer’s, the study found. […] Keeping your LDL cholesterol low could dramatically reduce your risk of dementia and statins can offer other benefits for those who qualify. […] People whose LDL cholesterol was below 70 mg/dL had a 26% reduced risk of dementia and a 28% reduced risk of Alzheimer’s specifically, compared to people whose LDL was 130 mg/dL or higher, according to new research. […] If you have type 2 diabetes and you’re north of 50, this finding matters to you: Taking a GLP-1 or a SGLT2i (two types of diabetes medications) was linked to a 33%-43% lower risk of Alzheimer’s or a related dementia. […] „What we know is that really focusing on your cardiometabolic health and reducing cholesterol and improving sleep and all of that, it all goes together,” Thiara said. „By reducing your risk of diabetes and heart attacks and strokes, you’re reducing your risk of developing dementia, and vice versa.”

• #40 Alzheimer’s Disease Prevention: 7 Tips To Lower Your Risk of Getting Alzheimer’s

  https://www.webmd.com/alzheimers/understanding-alzheimers-disease-prevention

  People who keep learning and stay social may be less likely to get Alzheimers disease. […] If you hurt your head in a car wreck or fall off a bike without a helmet on, it could make Alzheimers disease more likely years from now. […] Avoid all forms of tobacco. […] Eat a heart-healthy diet with lots of fruits and vegetables, whole grains, lean protein, and low-fat dairy. Limit saturated fat (found in meats and full-fat dairy products), added sugars, carbs, sodium, and alcohol.

• #41 From better diagnosis and treatments to prevention, the state of Alzheimer’s and other dementias | MUSC | Charleston, SC

  https://web.musc.edu/about/news-center/2023/12/04/from-better-diagnosis-and-treatments-to-prevention-the-state-of-alzheimers-and-other-dementias

  Doctors already know there are some risk factors for dementia, including: […] Environmental factors such as air pollution may play a role as well, according to many scientists, including researchers involved in a recent meta-analysis at the Harvard T.H. Chan School of Public Health. […] Those are things we can look out for, and in some cases, alter our behavior to prevent. […] Biomarkers, things about the body that can be tested and/or measured, can be important indicators, too. […] We’re going to look at things like blood and cerebrospinal spinal fluid for proteins that would tell us that someone is at risk for developing dementia. […] So scientists are trying to capture that, in some cases, through technology. […] We need to be able to identify those people who are triggering inflammation and getting into the very early stages of making amyloid and begin treatment with things like lecanemab.

• #42 THE PREVENTION OF ALZHEIMER’S DISEASE: LESSONS LEARNED AND APPLIED

  https://pmc.ncbi.nlm.nih.gov/articles/PMC5937943/

  While a well-balanced, healthy lifestyle may be the cornerstone of disease prevention and brain health, each individual risk factor (vascular, lifestyle choices, psychosocial) may act both independently and potentiate the effects of each other. […] Even if these precision approaches do not, in and of themselves, cure or prevent AD removing other pathways to neurodegeneration may greatly improve the likelihood of amyloid- or tau-specific therapies to reach their endpoints.

• #42 THE PREVENTION OF ALZHEIMER’S DISEASE: LESSONS LEARNED AND APPLIED

  https://pmc.ncbi.nlm.nih.gov/articles/PMC5937943/

  Assuming curing AD remains a substantial unsolved challenge, preventing or simply delaying the dementia onset could significantly change the face of disease. […] A number of prevention studies are ongoing in both sporadic and autosomal dominant forms of AD. […] A number of modifiable risk and preventive factors for AD have been described in observational studies (Table 1). […] The European Prevention of AD (EPAD) initiative is currently recruiting to examine whether alteration of risk factors for AD that occur in early- and mid-life potentiate pathophysiological changes decades before dementia onset. […] Overall between-group differences reached statistical significance for global cognition, executive function, and processing speed but not episodic memory. […] Up to 30% of AD cases may be preventable through modification of risk factors, and behavioral changes to mitigate the impact of those risk factors that are not modifiable.

• #43 The fight against Alzheimer’s | News

  https://news.llu.edu/health-wellness/fight-against-alzheimers

  Today, as co-directors of the Brain Health and Alzheimers prevention program at Loma Linda University Health, the duo has helped thousands of patients ranging from the partially cognitively impaired to those suffering from Alzheimers find hope through personal lifestyle intervention. […] In fact, we have found that more than 90% of cases can be prevented and it starts with how we take care of ourselves. […] Here at Loma Linda University Health, they have created the NEURO plan a lifestyle-focused approach to preventing Alzheimers, and authored the best-selling book The Alzheimers Solution to share their research with the world. […] We use the NEURO approach with our patients because its a comprehensive plan that improves multiples facets that affect our brain health. […] Looking at these two distinct populations, we consistently observed that our patients who were living healthier lifestyles had a much lower rates of dementia, Dean says.

• #44 Alzheimer’s and Prevention: Who Would Have Thought? – Advances for Medical Professionals | NewYork-Presbyterian

  https://www.nyp.org/publications/professional-advances/neuro/alzheimers-and-prevention-who-would-have-thought

  Findings from the 2015 Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER), a groundbreaking two-year proof-of-concept randomized controlled trial of over 1,200 people, suggest that a multidomain intervention diet, exercise, cognitive training, and vascular risk monitoring could improve or maintain cognitive functioning in at-risk elderly over time. […] Based on prevailing evidence, one out of three cases of Alzheimers disease may be preventable if we do everything right. […] Dr. Isaacson and his team have developed a framework for practice for neurologists in the field of Alzheimers prevention. […] We need to define what Alzheimers prevention is and isnt, and legitimize the evidence-based approach to prevention based on science, determining what is and what is not in our control. […] Dr. Isaacsons focus on prevention had its skeptics at first, but it seems like the tide is turning. […] In 2018, we can feel more comfortable using Alzheimers and prevention in the same sentence because the totality of evidence demonstrates that we can reduce risk, says Dr. Isaacson.

• #45 Several vaccines associated with reduced risk of Alzheimer’s disease in adults 65 and older – UTHealth Houston

  https://www.uth.edu/news/story/several-vaccines-associated-with-reduced-risk-of-alzheimers-disease-in-adults-65-and-older

  Several vaccinations were linked to a reduced risk of Alzheimer’s disease. […] Prior vaccination against tetanus and diphtheria, with or without pertussis (Tdap/Td); herpes zoster (HZ), better known as shingles; and pneumococcus are all associated with a reduced risk for developing Alzheimer’s disease, according to new research from UTHealth Houston. […] The new findings come just over a year after Schulz’s team published another study in the journal, which found that people who received at least one influenza vaccine were 40% less likely than their unvaccinated peers to develop Alzheimer’s disease. […] We and others hypothesize that the immune system is responsible for causing brain cell dysfunction in Alzheimer’s. The findings suggest to us that vaccination is having a more general effect on the immune system that is reducing the risk for developing Alzheimer’s.

• #45 Several vaccines associated with reduced risk of Alzheimer’s disease in adults 65 and older – UTHealth Houston

  https://www.uth.edu/news/story/several-vaccines-associated-with-reduced-risk-of-alzheimers-disease-in-adults-65-and-older

  Patients who received the Tdap/Td vaccine were 30% less likely than their unvaccinated peers to develop Alzheimer’s disease. […] Similarly, HZ vaccination was associated with a 25% reduced risk of developing Alzheimer’s disease. […] For the pneumococcal vaccine, there was an associated 27% reduced risk of developing the disease. […] We hypothesize that the reduced risk of Alzheimer’s disease associated with vaccines is likely due to a combination of mechanisms. […] The research provides unique insights on the possible impact of certain vaccine technologies in the protection against Alzheimer’s disease. […] This research highlights how important it is for patients to have ready access to routine adult vaccinations. […] Our findings are a win for both Alzheimer’s disease prevention research and for public health in general, as this is one more study demonstrating the value of vaccination.

• #46 Study strengthens link between shingles vaccine and lower dementia risk

  https://med.stanford.edu/news/all-news/2025/03/shingles-vaccination-dementia.html

  A new analysis of a vaccination program in Wales found that the shingles vaccine appeared to lower new dementia diagnoses by 20% more than any other known intervention. […] The remarkable findings, published April 2 in Nature, support an emerging theory that viruses that affect the nervous system can increase the risk of dementia. If further confirmed, the new findings suggest that a preventive intervention for dementia is already close at hand. […] By 2020, one in eight older adults, who were by then 86 and 87, had been diagnosed with dementia. But those who received the shingles vaccine were 20% less likely to develop dementia than the unvaccinated. […] Because of the unique way in which the vaccine was rolled out, bias in the analysis is much less likely than would usually be the case, Geldsetzer said.

• #47

  https://journals.publishing.umich.edu/ujph/article/id/3946/

  This paper explores the non-modifiable and modifiable risk factors for Alzheimers, as well as the Alzheimers primary prevention, secondary prevention, and tertiary prevention strategies that can be implemented. […] People can reduce their risk of developing Alzheimers by eating a healthy diet, using hearing aids for hearing loss, engaging in regular physical activity, spending time with other people, doing mentally stimulating activities, reducing alcohol consumption, and avoiding tobacco (Livingston et al., 2020). […] Primary and secondary prevention strategies must address the needs of minority populations, who have a higher risk of developing Alzheimers compared to the general population (Livingston et al., 2020). […] Public health professionals must address the escalating Alzheimers epidemic through the implementation of primary prevention strategies, which aim to prevent the illness from developing; secondary prevention strategies, which aim to diagnose and treat the disease before the disease becomes advanced and disability becomes severe; and tertiary prevention strategies, which aim to reduce the impact of a disease by minimizing suffering and improving quality of life.

• #47

  https://journals.publishing.umich.edu/ujph/article/id/3946/

  Primary prevention aims to decrease the proportion of people who develop Alzheimers by intervening on the non-modifiable risk factors and the modifiable risk factors. […] Modifiable risk factors cause about a third of Alzheimers cases worldwide, demonstrating that risk factor reduction can aid in Alzheimers prevention (Crous-Bou et al., 2017). […] The 2020 Lancet Commission on Dementia Prevention describes population-based interventions and individually targeted interventions for Alzheimers primary prevention. […] Preventive interventions must address racial and ethnic disparities in Alzheimers risk that occur due to the following socioeconomic factors: low household income, low education attainment, and low literacy level (Livingston et al., 2020). […] Secondary prevention aims to target the pre-symptomatic or preclinical stage and prevent the development of Alzheimers symptoms through the appropriate use of screening and early diagnostic tools, including biomarkers, scalable screening technologies, and cognitive assessments, followed by prompt treatment (McDade et al., 2021).

• #48 Alzheimer Prevention Trials (APT) Webstudy

  https://www.alzheimers.gov/clinical-trials/alzheimer-prevention-trials-apt-webstudy

  The Alzheimer Prevention Trials (APT) Webstudy is an online registry designed to accelerate enrollment for Alzheimer’s disease clinical trials by identifying and tracking individuals who may be at higher risk for developing Alzheimer’s dementia. […] Participants may also be invited for in-person testing at a clinical site, involving either a brain scan or a lumbar puncture (spinal tap) to look for beta-amyloid, a protein that accumulates abnormally in the brains of people with Alzheimer’s disease. […] Enrollment in this registry is online and study participation is available nationwide. […] Must have: Willing to participate in remote longitudinal cognitive testing and possible referral for biomarker assessment based on risk. […] Must NOT have: Evidence of dementia.

• #49 Prevent Alzheimer Program – The Douglas Research Centre

  https://douglas.research.mcgill.ca/prevent-alzheimer-program/

  The PREVENT-Alzheimer program wants to recruit 500 participants. Their contributions will be the key to finding strategies that can slow or reverse brain changes that may occur in older people who do not suffer from dementia. […] The goal of this program is to study memory and brain changes in healthy people over the age of 55. […] The program examines its participants every year for changes in memory, brain chemistry, and scan results. Program participants are also invited to join one of several clinical trials (experiments) run by the StoP-AD Centre to test the effectiveness of prevention strategies. […] The PREVENT-Alzheimer program is bringing crucial information to better understand the biological processes underlying disease emergence and progression and to contribute to the development of promising interventions in individuals who may have pre-symptomatic AD. […] Prevention is the ultimate cure !

• #50 International Alzheimer’s prevention trial in young adults begins – WashU Medicine

  https://medicine.washu.edu/news/international-alzheimers-prevention-trial-in-young-adults-begins/

  The international trial, led by WashU Medicine, aims to determine whether stopping the early molecular changes that lead to symptomatic Alzheimers disease can prevent the disease from ever taking hold. […] The study is enrolling people as young as 18 who have few or no detectable Alzheimers-related molecular changes in their brains, up to 25 years before the expected onset of dementia symptoms. […] By clearing out low levels of amyloid beta plaques or preventing them from accumulating during the early, asymptomatic phase of the disease, or both, the researchers hope to interrupt the disease process at the earliest stage and spare people from ever developing symptoms. […] This provides strong support for our hypothesis that intervening when amyloid beta plaques are at the very earliest stage, long before symptoms arise, could prevent symptoms from emerging in the first place.

• #50 International Alzheimer’s prevention trial in young adults begins – WashU Medicine

  https://medicine.washu.edu/news/international-alzheimers-prevention-trial-in-young-adults-begins/

  The Primary Prevention Trial will enroll about 240 participants from families that carry mutations in one of the three key genes that cause early-onset Alzheimers. […] McDade and colleagues are primarily looking to see whether remternetug prevents amyloid plaques from building up in the brain. […] This innovative study in this special Alzheimers patient population has the potential to significantly impact how we prevent Alzheimers disease, saving individuals and families from the anguish of this fatal disease. […] For the first time, we’re working to prevent the buildup of Alzheimers pathology before it starts. The research will provide insight on how we prevent Alzheimers disease for these families, as well as the nearly 13 million Americans projected to have Alzheimers disease by 2050 and countless others around the world.

• #51 Primary and Secondary Prevention of Alzheimer’s Disease: Dr. Jessica Langbaum shares the latest from the field | Institute on Aging | Perelman School of Medicine at the University of Pennsylvania

  https://www.med.upenn.edu/aging/langbaum.html

  Dr. Langbaum’s work highlights the importance of identifying individuals who are genetically predisposed to Alzheimer’s, such as those with the APOE4 gene variant, and offering them interventions that might slow or halt the progression of amyloid plaque accumulation. […] The first primary prevention trials will likely focus on people at genetic risk and who have a blood biomarker test (such as pTau217) that may be on the rise, but doesnt yet meet criteria for a positive test, indicative of amyloid pathology. These trials would evaluate the ability of the treatments to avert the onset of amyloid plaques. […] As for secondary prevention, this is focused on individuals without any symptoms and with one or more risk factors of the disease, such as having a genetic risk factor, and/or having biomarker evidence of disease such as having elevated brain amyloid.

• #52 Anti-amyloid drug shows signs of preventing Alzheimer’s dementia – WashU Medicine

  https://medicine.washu.edu/news/anti-amyloid-drug-shows-signs-of-preventing-alzheimers-dementia/

  Clinical trial of people destined to develop early-onset Alzheimers disease shows eliminating amyloid from brain may prevent symptoms, supports need for confirmatory studies […] An experimental drug appears to reduce the risk of Alzheimers-related dementia in people destined to develop the disease in their 30s, 40s or 50s, according to the results of a study led by the Knight Family Dominantly Inherited Alzheimer Network-Trials Unit (DIAN-TU), which is based at Washington University School of Medicine in St. Louis. The findings suggest for the first time in a clinical trial that early treatment to remove amyloid plaques from the brain many years before symptoms arise can delay the onset of Alzheimers dementia. […] In order to give them the best opportunity to stay cognitively normal, we have continued treatment with another anti-amyloid antibody in hopes they will never develop symptoms at all. What we do know is that its possible at least to delay the onset of the symptoms of Alzheimers disease and give people more years of healthy life.

• #52 Anti-amyloid drug shows signs of preventing Alzheimer’s dementia – WashU Medicine

  https://medicine.washu.edu/news/anti-amyloid-drug-shows-signs-of-preventing-alzheimers-dementia/

  The findings provide new evidence to support the so-called amyloid hypothesis of Alzheimers disease, which posits that the first step on the road to dementia is the build-up of amyloid plaques in the brain, and that removing such plaques or blocking their formation can stop symptoms from arising. […] Analysis of this data set revealed that removal of brain amyloid plaques years before symptoms are expected to arise delayed symptom onset and dementia progression, although the results were only statistically significant for the subgroup of people who started with no symptoms and were treated the longest. […] If late-onset Alzheimers prevention trials have similar results to the DIAN-TU trials, there soon could be Alzheimers preventions available for the general population, Bateman said. I am highly optimistic now, as this could be the first clinical evidence of what will become preventions for people at risk for Alzheimers disease. One day soon, we may be delaying the onset of Alzheimers disease for millions.

• #53 New Alzheimer’s prevention trial receives $74.5 million NIH grant – Arizona Alzheimer’s Consortium

  https://azalz.org/new-alzheimers-prevention-trial-receives-74-5-million-nih-grant/

  Banner Alzheimers Institute has sought to find effective Alzheimers disease prevention therapies within twenty years. […] The Alzheimers Prevention Initiative (API) is an international collaborative formed in 2009 to launch a new era of Alzheimers prevention research. […] API continues to establish brain imaging, fluid biomarker and cognitive endpoints needed to rapidly test promising prevention therapies. […] GNA has also characterized large and paradigmatic populations with other forms of dementia and other neurogenetic disorders.

• #54 Public Health Approach to Alzheimer’s | Alzheimer’s Association

  https://www.alz.org/professionals/public-health/public-health-approach

  Increasingly, communities around the country are taking a public health approach to address Alzheimer’s, a pivotal and growing public health crisis that requires robust responses. […] There are public health tools and strategies that can improve health outcomes for people affected by dementia in every community. A strong public health response implements population-based solutions that include: Promoting brain health. Increasing access to early detection and diagnosis. Supporting people living with dementia and their caregivers. […] Risk Reduction (primary prevention) can have the biggest impact across a population. Much can be done to reduce risk of cognitive decline and possible dementia. Examples include lowering blood pressure, eating healthy and doing physical activity. […] Early Detection and Diagnosis (secondary prevention) can improve access to and knowledge of diagnostic services and supports, and the early warning signs of dementia. Public health action on early detection can include work that changes the culture around talking about memory and thinking problems, both among the public and among health care providers. […] Safety and Quality of Care (tertiary prevention) can help support people living with dementia and their caregivers. Public health action can help ensure access to and knowledge of supports and services, improve community-clinical linkages, and strengthen training of care providers.

• #55 Dementias – Healthy People 2030 | odphp.health.gov

  https://odphp.health.gov/healthypeople/objectives-and-data/browse-objectives/dementias

  Alzheimers disease is the most common cause of dementia and the sixth leading cause of death in U.S. adults. Nearly 6 million people in the United States have Alzheimers, and that number will increase as the population ages. Healthy People 2030 focuses on improving care and quality of life for people with Alzheimers and other causes of dementia. […] While theres no cure for Alzheimers disease, early diagnosis and supportive care can improve quality of life. And efforts to make sure adults with symptoms of cognitive decline including memory loss are diagnosed early can help improve health outcomes in people with dementia. Interventions to address caregiving needs can also help improve health and well-being in people with dementia.

• #56 Reducing the Risk for Alzheimer’s Disease

  https://www.cedars-sinai.org/newsroom/reducing-the-risk-for-alzheimers-disease/

  Cedars-Sinai has launched a program to help people 40 and older who do not have Alzheimers disease but want to understand and reduce their risk for developing the illness. […] There are tactics to prevent or reduce ones risk for it. While we continue to search for a viable path for stopping this disease in its entirety, prevention is of the utmost importance. […] The Cedars-Sinai program is open to anyone 40 to 60 years old with at least two of these risk factors, and anyone 60 or older who doesn’t have signs of Alzheimers disease or dementia but wants to protect their brain health. […] Studies show that as many as 40% of cases of Alzheimers disease and related dementias can be prevented or delayed with the right clinical guidance. […] We want to help people take preventive action as early as possible, Tan said. Delaying the onset of Alzheimers disease for even five to eight years is tantamount to a cure for many people, because the greatest risk is in those ages 80 and up. Those who delay onset until their late 80s might avoid it altogether.

• #57 National Plan to Address Alzheimer’s Disease | ASPE

  https://aspe.hhs.gov/collaborations-committees-advisory-groups/napa/napa-documents/napa-national-plan

  National Plan establishes six ambitious goals to both prevent future cases of Alzheimer’s disease and related dementias (AD/ADRD), and to better meet the needs of the millions of American families currently facing this disease. […] (NEW) Accelerate Action to Promote Healthy Aging and Reduce Risk Factors for AD/ADRD. […] reducing the risk of AD/ADRD by promoting brain health.

• #58 National Plan to Address Alzheimer’s Disease | ASPE

  https://aspe.hhs.gov/national-plan-address-alzheimers-disease

  To educate health care providers on ways to better identify and treat Alzheimer’s disease and its symptoms, the Obama Administration’s Alzheimer’s disease announcement includes a new $6 million investment over two years for provider education and outreach. Provider training and awareness is essential to effectively detecting Alzheimer’s disease and caring for people affected by this devastating disease. […] Strategy 2.H: Improve Care for Populations Disproportionally Affected by Alzheimer’s Disease and for Populations Facing Care Challenges […] Some populations are unequally burdened by Alzheimer’s disease, including racial and ethnic minorities and people with intellectual disabilities. Racial and ethnic minorities are at greater risk for developing Alzheimer’s disease and face barriers to obtaining a diagnosis and services after onset. People with Down syndrome almost always develop AD as they age. In addition, because AD primarily affects older adults, the population with younger-onset AD faces unique challenges with diagnosis, care, and stigma. HHS will undertake the actions below to better understand the unique challenges faced by these groups and create a plan for improving the care that they receive, which will be integrated into the broader efforts to improve care for all people with AD.

• #59 Can I Prevent Dementia?

  https://www.alzheimers.gov/life-with-dementia/can-i-prevent-dementia

  As you age, you may have concerns about the increased risk of dementia. […] There are currently no approaches that have been proven to prevent Alzheimers disease and related dementias. However, as with many other diseases, there may be steps you can take to help reduce your risk. […] For Alzheimers and related dementias, no behavior or lifestyle factors have risen to the level of researchers being able to say: This will definitely prevent these diseases. But there are promising avenues. […] Although there is no effective treatment or proven prevention for Alzheimers and related dementias, in general, leading a healthy lifestyle may help address risk factors that have been associated with these diseases. […] Researchers cannot say for certain whether making the above lifestyle changes will protect against dementia, but these changes are good for your health and are all part of making healthy choices as you age. […] More research is needed to find ways to help prevent Alzheimers and related dementias.

• #60 Research Priorities for Preventing and Treating Alzheimer’s Disease and Related Dementias | National Academies

  https://www.nationalacademies.org/our-work/research-priorities-for-preventing-and-treating-alzheimers-disease-and-related-dementias

  Building on its review of past AD/ADRD strategic planning and related activities, existing literature and analyses, and other expert and public input, the committee will develop a report with its findings, conclusions, and recommendations on research priorities for preventing and treating AD/ADRD, including identifying specific near- and medium-term scientific questions (i.e., in a 3-to-10-year period) that may be addressed through National Institutes of Health (NIH) funding. The report will also include strategies for addressing major barriers to progress on these scientific questions.

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