Materiały źródłowe

• #1 Endocarditis – Symptoms & causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/endocarditis/symptoms-causes/syc-20352576

  Endocarditis may develop slowly or suddenly. It depends on the type of germs causing the infection and whether there are other heart problems. […] Symptoms of endocarditis can vary from person to person. Common symptoms of endocarditis include: Aching joints and muscles, Chest pain when you breathe, Fatigue, Flu-like symptoms, such as fever and chills, Night sweats, Shortness of breath, Swelling in the feet, legs or belly, A new or changed whooshing sound in the heart (murmur). […] Less common endocarditis symptoms can include: Unexplained weight loss, Blood in the urine, Tenderness under the left rib cage (spleen), Painless red, purple or brown flat spots on the soles bottom of the feet or the palms of the hands (Janeway lesions), Painful red or purple bumps or patches of darkened skin (hyperpigmented) on the tips of the fingers or toes (Osler nodes), Tiny purple, red or brown round spots on the skin (petechiae), in the whites of the eyes or inside the mouth. […] If you’ve been diagnosed with endocarditis and have any of the following symptoms, tell your care provider. These symptoms may mean the infection is getting worse: Chills, Fever, Headaches, Joint pain, Shortness of breath.

• #1 Infective Endocarditis – Heart and Blood Vessel Disorders – Merck Manual Consumer Version

  https://www.merckmanuals.com/home/heart-and-blood-vessel-disorders/endocarditis/infective-endocarditis

  Acute infective endocarditis usually begins suddenly with a high fever, fast heart rate, fatigue, and rapid and extensive heart valve damage. […] Subacute infective endocarditis gradually causes such symptoms as fatigue, mild fever, a moderately fast heart rate, weight loss, sweating, and a low red blood cell count. […] In both acute and subacute infective endocarditis, arteries may become blocked if accumulations of bacteria and blood clots on the valves break loose, travel through the bloodstream to other parts of the body, and lodge in an artery, blocking it. […] Heart valves may become perforated and may start to leak within a few days. Some people go into shock, and their kidneys and other organs stop functioning. […] Other symptoms of acute and subacute infective endocarditis may include chills, joint pain, paleness, painful nodules under the skin, and confusion.

• #1 Endocarditis Information | Mount Sinai – New York

  https://www.mountsinai.org/health-library/diseases-conditions/endocarditis

  Endocarditis is inflammation of the inside lining of the heart chambers and heart valves (endocardium). It is most often caused by a bacterial or, rarely, a fungal infection. […] Symptoms of endocarditis may develop slowly or suddenly. Fever, chills, and sweating are frequent symptoms. These sometimes can: Be present for days before any other symptoms appear, Come and go, or be more noticeable at nighttime. […] You may also have fatigue, weakness, weight loss, loss of appetite, and aches and pains in the muscles or joints. Other signs can include: Small areas of bleeding under the nails (splinter hemorrhages), Red, painless skin spots on the palms and soles (Janeway lesions), Red, painful nodes in the pads of the fingers and toes (Osler nodes), Shortness of breath with activity, Swelling of feet, legs, abdomen.

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• #1 Endocarditis Causes & Symptoms | Tampa General Hospital

  https://www.tgh.org/institutes-and-services/conditions/endocarditis

  The early symptoms of endocarditis can mimic those of a seasonal cold or allergies, which means many cases go undiagnosed. Fever, chills, a sore throat, nasal congestion, headaches, sinus pressure, white patches in the mouth and a persistent cough are all common symptoms of endocarditis. However, symptoms that differentiate themselves from a cold include: […] Individuals with a history of heart problems should be especially watchful for symptoms of this condition. It is important to promptly seek medical attention if symptoms occur, as life-threatening complications can develop if left untreated.

• #1 Endocarditis – causes, symptoms and treatments – BHF

  https://www.bhf.org.uk/informationsupport/conditions/endocarditis

  The symptoms of endocarditis can be hard to notice and unclear, developing slowly over weeks or sometimes months. In some cases, however, they can develop suddenly. […] The most common symptoms of endocarditis are: flu-like symptoms these include having a temperature, tiredness, headaches, chills, a cough and sore throat, poor appetite or unexplained weight loss, pale skin, aching muscles and joints, heart murmurs (an abnormal heart sound). […] Other rarer symptoms you may see or feel include: small dark-coloured spots on the skin, unusual dark lines under your fingernails, red lumps on the fingers or toes that might be painful. […] If you’ve been told you’re at high risk of developing endocarditis and you have flu-like symptoms with a high temperature for more than a week, see your GP immediately.

• #1 Endocarditis | Infective Endocarditis | IE | MedlinePlus

  https://medlineplus.gov/endocarditis.html

  Endocarditis symptoms may be severe or very mild. They may start suddenly or slowly. And they can vary from person to person. The possible symptoms of endocarditis include: […] Fever and chills […] New or worsening heart murmur (an unusual sound heard between heartbeats) […] Chest pain […] Cough […] Muscle, joint, and back pain […] Night sweats (heavy sweating during sleep) […] Shortness of breath (feeling like you can’t get enough air) […] Skin changes, including: […] Broken blood vessels […] Painful red or purple bumps […] Painless flat red spots on the palms of your hands or soles of your feet.

• #1 Infective Endocarditis – Heart and Blood Vessel Disorders – Merck Manual Consumer Version

  https://www.merckmanuals.com/home/heart-and-blood-vessel-disorders/endocarditis/infective-endocarditis

  Tiny reddish spots that resemble freckles may appear on the skin and in the whites of the eyes. Small streaks of red may appear under the fingernails. […] Prosthetic valve endocarditis may be an acute or subacute infection. Compared with infection of a natural valve, infection of a replacement valve is more likely to spread to the heart muscle at the base of the valve and can loosen the attachment of the valve to the heart.

• #1 Infective endocarditis – Overview | Guy’s and St Thomas’ NHS Foundation Trust

  https://www.guysandstthomas.nhs.uk/health-information/infective-endocarditis

  Symptoms can develop quickly in days, or slowly over weeks. It is vital to get medical attention at the earliest signs, so that you can have blood tests to try and identify the cause. […] The most common symptoms of endocarditis include: […] unexplained flu-like symptoms (high temperature or fever, sweats, chills) that are severe or last longer than a week […] weight loss, poor appetite […] general fatigue and feeling unwell […] new back pain. […] Without early treatment you can have complications. These include: […] confusion or drowsiness […] shortness of breath from severe valve damage […] stroke […] cold leg from a blocked artery […] boils or black patches on the toes or fingers.

• #1 Infective endocarditis – Wikipedia

  https://en.wikipedia.org/wiki/Infective_endocarditis

  Signs and symptoms may include fever, small areas of bleeding into the skin, heart murmur, feeling tired, and low red blood cell count. […] Complications may include backward blood flow in the heart, heart failure the heart struggling to pump a sufficient amount of blood to meet the body’s needs, abnormal electrical conduction in the heart, stroke, and kidney failure. […] Infective endocarditis occurs in males more often than in females. […] The risk of death among those infected is about 25%. […] Without treatment, it is almost universally fatal. […] Improved diagnosis and treatment options have significantly enhanced the life expectancy of patients with infective endocarditis, particularly with congenital heart disease. […] Infective endocarditis is associated with 18% in-hospital mortality. […] However, adult patients with congenital heart disease can have relatively lower mortality down to 5% due to younger age, right-sided endocarditis and management by multidisciplinary teams. As many as 50% of people with infective endocarditis may experience embolic complications.

• #1 Infective Endocarditis: Symptoms and Treatment

  https://patient.info/doctor/infective-endocarditis-pro

  Infective endocarditis complications […] These are an inherent part of the progression of the disease. Potential complications of IE include: myocardial infarction, pericarditis, cardiac arrhythmias. […] Heart valve insufficiency. […] Congestive heart failure. […] Sinus of Valsalva aneurysm. […] Aortic root or myocardial abscesses. […] Arterial emboli, infarctions, mycotic aneurysms. […] Arthritis, myositis. […] Glomerulonephritis, acute kidney injury. […] Stroke syndromes. […] Mesenteric or splenic abscess or infarction. […] Infective endocarditis prognosis […] Although novel diagnostic and therapeutic strategies have emerged, the overall one-year mortality has not improved and remains at 30%. […] However, the prognosis varies markedly according to a variety of factors. Predictors of poor outcome include: Patient characteristics: older age, prosthetic valve IE, diabetes, comorbidity (eg, frailty, immunosuppression, renal or pulmonary disease). […] Clinical complications of IE: heart failure, renal failure, greater than moderate area of ischaemic stroke, brain haemorrhage, septic shock. […] Micro-organism: S. aureus, fungi, non-HACEK Gram-negative bacilli. […] Echocardiogram findings: peri-annular complications, severe left-sided valve regurgitation, low left ventricular ejection fraction, pulmonary hypertension, large vegetations, severe prosthetic valve dysfunction, premature mitral valve closure and other signs of elevated diastolic pressures.

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  https://www.nhs.uk/conditions/endocarditis/

  The initial symptoms of endocarditis are similar to flu and include: a high temperature, chills, headache, joint and muscle pain. […] Without treatment, the infection damages the heart valves and disrupts the normal flow of blood through the heart. […] This could trigger a range of life-threatening complications, such as: heart failure where the heart is unable to pump enough blood around the body to properly meet the body’s demands, stroke where the supply of blood to the brain becomes disrupted.

• #1 Endocarditis Information | Mount Sinai – New York

  https://www.mountsinai.org/health-library/diseases-conditions/endocarditis

  Getting treatment for endocarditis right away improves the chances of a good outcome. More serious problems that may develop include: Brain abscess, Further damage to the heart valves, causing heart failure, Spread of the infection to other parts of the body, Stroke, caused by small clots or pieces of the infection breaking off and traveling to the brain.

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  https://myhealth.alberta.ca/Health/pages/conditions.aspx?hwid=hw164664

  Symptoms may appear quickly, within a few days of infection. In other cases, they may develop more slowly. The symptoms will get worse as the bacteria or fungi grow in your heart. […] Symptoms may include: Flu-like symptoms such as fever, chills, night sweats, and fatigue. These are often the first symptoms. Weight loss. Muscle or joint pain. Cough. Shortness of breath. Blood under the fingernails or tiny purple and red spots under the skin. […] If endocarditis isn’t treated soon, it can lead to more serious problems, such as: Heart failure. An abscess in the heart. Heart rhythm problems. Heart attack or stroke. Infections in other organs, such as the lungs, brain, or kidneys.

• #1 What Is Endocarditis? Learn Causes, Symptoms & Treatment – BuzzRx

  https://www.buzzrx.com/blog/what-is-endocarditis

  Endocarditis is a rare but serious condition requiring immediate medical attention. Common signs include fever, fatigue, joint pain, skin rashes, night sweats, shortness of breath, and swelling in the abdomen, feet, and legs. […] Early recognition of endocarditis is important because the condition can be fatal without timely and aggressive treatment. Left untreated, the vegetation (bacteria that have attached to the damaged heart valves) can continue multiplying and eventually destroy heart tissue. This can result in complications such as leaky heart valves, embolus formation (a small blood clot that can leave the heart and block small arteries), abnormal heart rhythm, abscess formation (pus collection near the heart), sepsis (spread of the infection throughout the body), and heart failure.

• #1 Bacterial Endocarditis | Cedars-Sinai

  https://www.cedars-sinai.org/health-library/diseases-and-conditions/b/bacterial-endocarditis-adult.html

  Symptoms may come on suddenly and be severe. Or, they may happen slowly and be less severe. Symptoms may include: […] Bacterial endocarditis is a serious condition that can sometimes lead to death, especially if not treated right away. […] In some cases, the symptoms start suddenly and are severe. This is called acute bacterial endocarditis. In other cases, it happens more slowly and is less severe. This is called subacute bacterial endocarditis.

• #1 Infective Endocarditis Clinical Presentation: History, Physical Examination, Complications

  https://emedicine.medscape.com/article/216650-clinical

  The clinical symptoms of acute IE result from either embolic or intracardiac suppurative complications. The onset of illness is abrupt, with rapidly progressive destruction of the infected valve. The valvular leaflets are quickly destroyed by bacteria that multiply rapidly within the ever-growing friable vegetations. Complications develop within a week. These include the dyspnea and fatigue of severe congestive heart failure and a wide spectrum of neuropsychiatric complications resulting from CNS involvement.

• #1 Quick Facts:Infective Endocarditis – MSD Manual Consumer Version

  https://www.msdmanuals.com/home/quick-facts-heart-and-blood-vessel-disorders/endocarditis/infective-endocarditis

  Infective endocarditis usually develops slowly. But sometimes it comes on quickly. […] Subacute infective endocarditis is when endocarditis develops slowly, over weeks to months. You gradually develop symptoms such as: Tiredness, Low fever (99 to 101 F or 37.2 to 38.3 C), Weight loss, Sweating. […] Acute infective endocarditis starts suddenly, and you become very ill quickly. One of your heart valves may be severely damaged within days. Symptoms include: High fever (102 to 104 F or 38.9 to 40 C), Extreme tiredness, Difficulty breathing. […] With either type of endocarditis, you may also have: Chills, Joint pain, Pale skin, Painful lumps under your skin.

• #1 What Is Endocarditis? Learn Causes, Symptoms & Treatment – BuzzRx

  https://www.buzzrx.com/blog/what-is-endocarditis

  Acute infective endocarditis begins suddenly and can become life-threatening within days. It is associated with severe symptoms of endocarditis and serious complications such as stroke, pulmonary embolism (blood clots in the lungs), sepsis, heart attacks, and heart failure. […] Subacute infective endocarditis tends to develop slowly over several weeks to months. It causes nonspecific symptoms such as fever, chills, night sweats, trouble breathing, and muscle aches. Diagnosis of subacute endocarditis is often delayed due to the endocarditis symptoms being nonspecific.

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  https://www.nhs.uk/conditions/endocarditis/symptoms/

  The symptoms of endocarditis can develop rapidly over a few days (acute endocarditis), or slowly over a few weeks or possibly months (subacute endocarditis). […] The most common symptoms of endocarditis include: a high temperature, chills, night sweats, headaches, shortness of breath, especially during physical activity, cough, tiredness (fatigue), muscle and joint pain. […] Other symptoms can include: small red, brown or purple spots on the skin (petechiae); these may be harder to see on brown and black skin, narrow, reddish-brown lines of blood that run underneath the nails, painful red lumps in the pads of the fingers and toes, but redness can be harder to see on brown and black skin, painless red spots on the palms and soles, but redness can be harder to see on brown and black skin, confusion, loss of appetite, unexpected weight loss. […] Contact your GP as soon as possible if you develop any symptoms of endocarditis, particularly if you’re at a higher risk of developing it, such as if you have a history of heart disease.

• #1 Endocarditis in Dogs | VCA Animal Hospitals

  https://vcahospitals.com/know-your-pet/endocarditis-in-dogs

  Signs of endocarditis are often nonspecific early in the course of the disease. Affected dogs show vague signs of illness, such as weight loss and lethargy. […] In later stages, endocarditis begins to affect the functioning of the heart. Dogs may develop signs of heart failure, such as a cough, exercise intolerance, and weakness. You may also notice that your dog has shortness of breath or difficulty breathing. […] The prognosis for endocarditis in dogs varies, depending on factors such as which heart valve is affected, what bacteria is causing the infection, and the dog’s overall health. Endocarditis that affects the aortic valve typically carries a poor prognosis, while mitral valve endocarditis often progresses much more slowly (over a period of months to years).

• #1 Pediatric Endocarditis Symptoms & Treatment | Lurie Children’s

  https://www.luriechildrens.org/en/specialties-conditions/endocarditis/

  People with endocarditis have a variety of symptoms. The symptoms may appear over a period of days or weeks. In initial stages of infectious endocarditis, the symptoms may be mistaken for the flu. […] The most usual symptoms are: Persistent fevers, Night sweats, Chills, Loss of appetite, Fatigue, Joint and muscle pain, Shortness of breath. […] Less common symptoms include: Weight loss, Janeway lesions (painless red, purple, or brown flat spots on the bottom of the feet or palms of the hands), Osler nodes (painful red or purple bumps or patches of darkened skin on the tips of fingers or toes), Petechiae to the whites of the eyes or inside the mouth (tiny purple, red, or brown round spots on the skin). […] These symptoms are nonspecific and may be seen in many types of inflammation. Symptoms of heart failure such as fatigue, shortness of breath, elevated heart rate or rate of breathing, swelling of the legs, lightheadedness or fainting are more specific for a heart problem.

• #1 Endocarditis: Symptoms & Treatment | Mass General Brigham

  https://www.massgeneralbrigham.org/en/patient-care/services-and-specialties/heart/conditions/endocarditis

  Endocarditis is a serious condition, and treatment should begin as soon as possible to prevent damage to the heart valves, which can lead to more serious endocarditis complications. […] Endocarditis can be fatal if left untreated and with too much damage to the heart valve. […] In general, earlier treatment for endocarditis leads to a better long-term outlook. Most patients who receive aggressive treatment early will recover without any lasting effects. […] If a patient has already had infective endocarditis, they are at increased risk to develop endocarditis again.

• #1 Endocarditis – causes, symptoms and treatments – BHF

  https://www.bhf.org.uk/informationsupport/conditions/endocarditis

  Infective endocarditis can be fatal if left untreated. Therefore, early detection and prompt management are critically important. […] You should contact your healthcare provider as soon as possible if you recognise the above symptoms. This is especially important if you’re at higher risk of developing endocarditis, such as having a history of heart valve disease.

• #1 Infective Endocarditis Clinical Presentation: History, Physical Examination, Complications

  https://emedicine.medscape.com/article/216650-clinical

  Acute disease has become the predominant type of valvular infection because of the rise in intravascular devices such as prosthetic valves and pacemakers. The symptoms often are vague and constitutional in nature. They may focus on primary cardiac effects or secondary embolic phenomena. Fever and chills are the most common symptoms. Anorexia, weight loss, malaise, headache, myalgias, night sweats, shortness of breath, cough, and joint pains are commonly observed. […] A key concern is the distinction between subacute and acute IE. The diagnosis of subacute IE is suggested by a history of an indolent process characterized by fever, fatigue, anorexia, back pain, and weight loss. Less common developments include cerebrovascular accident or congestive heart failure. […] Acute IE is a much more aggressive disease. The patient notices the rapid onset of high-grade fevers and chills and a rapid onset of congestive heart failure.

• #1 Infective Endocarditis: Symptoms and Treatment

  https://patient.info/doctor/infective-endocarditis-pro

  Cure rates […] NVE: S. viridans 98% cure rate. […] S. aureus 60-70% cure rate with worse results in those NOT abusing intravenous drugs. […] Fungal infections – cure rate less than 50%. […] PVE: Cure rates at least 10% lower than above for each variety. […] Surgery needed more often. […] Mortality […] Mortality rates in NVE range from 16-27%. Mortality rates in patients with PVE are higher. […] Increased mortality rates are associated with increased age, infection involving the aortic valve, development of congestive heart failure, central nervous system complications and underlying disease – eg, diabetes. […] Mortality rates also vary with the infecting organism: Acute endocarditis due to S. aureus is associated with a high mortality rate (30-40%), except when it is associated with intravenous drug use. […] Endocarditis due to streptococci has a mortality rate of approximately 10%.

• #1 Endocarditis: Symptoms, causes, treatments, and more

  https://www.medicalnewstoday.com/articles/151016

  Without prompt treatment, endocarditis may cause serious heart damage or death. A person needs to speak with a doctor immediately if they notice any signs of endocarditis. […] The mortality rate of endocarditis is around 20% within 30 days of infection. A person is unlikely to survive without antibiotics. […] Endocarditis can cause symptoms such as fever, chills, night sweats, and shortness of breath. If a person develops symptoms of endocarditis, they need to seek immediate medical advice. Without prompt treatment, it can cause serious heart damage or death. […] Most people recover from endocarditis. Receiving an early diagnosis and beginning antibiotic treatment as early as possible can help improve a persons outlook.

• #1 Endocarditis | Conditions | UCSF Benioff Children’s Hospitals

  https://www.ucsfbenioffchildrens.org/conditions/endocarditis

  The usual signs of endocarditis are prolonged fever for several days (occasionally up to 30 days) in a child with congenital heart disease that occurs after a procedure in the mouth, intestinal tract or urinary tract. However, the infection may occur without a previous procedure. […] Symptoms of endocarditis may develop slowly or come on suddenly. They include: Fatigue, Fever, Headache, Joint inflammation or pain, Night sweats, Poor appetite and/or weight loss, Rash. […] More severe symptoms include: Anemia, An enlarged spleen, Bleeding that causes small dark lines under the fingernails or small dark spots on the skin, New heart murmurs. […] Early treatment is usually successful. However, it is possible for heart failure to develop, and this risk increases the longer treatment is delayed. If heart failure occurs, your child may need surgery to repair or replace the affected heart valve. If the diagnosis is delayed and severe heart damage has occurred, the child may die.

• #1 Signs and Symptoms

  http://www.cardiosmart.org/topics/endocarditis/signs-and-symptoms

  The most common symptoms of Endocarditis are: Fever, Chills, Sweats, General malaise. […] Your doctor also may identify a new or worsening heart murmur. If your heart valve is significantly affected, you may have shortness of breath and other symptoms of congestive heart failure. Endocarditis involving valves on the left side the heart (aortic and mitral valves) may cause a stroke. This can occur if parts of the infection break off the valve and travel to the brain. Signs and symptoms of stroke include a sudden change in vision, speech, movement, or consciousness. Some patients have symptoms that go on for a while or are vague. This is called subacute endocarditis. […] Other signs and symptoms include dark marks on the palms and soles, or painful red marks on the hands and feet.

• #1 Infective endocarditis – Cardiology Explained – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK2208/

  An acute confusional state is common in patients with infective endocarditis (IE). Cerebral emboli, which usually affect the middle cerebral artery, result in hemiplegia and sensory dysfunction. […] Infarction causes loin pain and hematuria. Immune complex deposition may result in glomerulonephritis. […] If any of these signs occur together with a fever, the patient should be urgently referred to a cardiologist for blood cultures and echocardiography the level of risk will determine whether this is transesophageal echo (TEE) or transthoracic echo. […] The Duke diagnostic classification for IE divides signs and symptoms into major and minor criteria. IE is diagnosed if patients have: two major criteria; or one major and three minor criteria; or five minor criteria. […] With effective treatment, patients with IE have a 70% survival rate. The prognosis is worse if there is no identifiable organism or if there is a resistant organism. Fungal infections are associated with increased mortality, as is prosthetic valve endocarditis. Overall death rates are 20% for native valve endocarditis, 30% for staphylococcal infections, and 20%30% for late prosthetic valve infection, despite full medical and surgical treatment. The most common cause of death is intractable heart failure.

• #2 Bacterial Endocarditis | Cedars-Sinai

  https://www.cedars-sinai.org/health-library/diseases-and-conditions/b/bacterial-endocarditis-adult.html

  Symptoms may come on suddenly and be severe. Or, they may happen slowly and be less severe. Symptoms may include: […] Bacterial endocarditis is a serious condition that can sometimes lead to death, especially if not treated right away. […] In some cases, the symptoms start suddenly and are severe. This is called acute bacterial endocarditis. In other cases, it happens more slowly and is less severe. This is called subacute bacterial endocarditis.

• #2 Endocarditis: Symptoms, Causes, & Treatment | University of Utah Health | University of Utah Health

  https://healthcare.utah.edu/cardiovascular/conditions/endocarditis

  Symptoms of endocarditis include the following: […] Fast heart rate or trouble breathing […] Over time, these growths can destroy the heart tissue and valves. They can cause heart failure or problems with the heart rhythm. […] Acute endocarditis develops suddenly and may become life threatening within days. […] Subacute or chronic endocarditis develops slowly over a period of weeks to several months.

• #2 Heart Valves and Infective Endocarditis | American Heart Association

  https://www.heart.org/en/health-topics/heart-valve-problems-and-disease/heart-valve-problems-and-causes/heart-valves-and-infective-endocarditis

  The symptoms of acute IE usually begin with fever, chills, fast heart rate, fatigue, night sweats, aching joints and muscles, persistent cough or swelling in the feet, legs or abdomen. […] The symptoms of chronic IE may include fatigue, mild fever, a moderately fast heart rate, weight loss, sweating and a low red blood cell count (anemia).

• #2 Endocarditis: Causes, Symptoms and Treatment

  https://my.clevelandclinic.org/health/diseases/16957-endocarditis

  Signs of an endocarditis infection include: Fever above 100F (38.4C). Sweats or chills, particularly night sweats. Skin rash. Pain, tenderness, redness or swelling. Wound or cut that won’t heal. Red, warm or draining sore. Sore throat, scratchy throat or pain when swallowing. Sinus drainage, nasal congestion, headaches or tenderness along your upper cheekbones. Persistent dry or a moist cough that lasts more than two days. White patches in your mouth or on your tongue. Nausea, vomiting or diarrhea. Emboli (small blood clots), hemorrhages (internal bleeding) or stroke. Shortness of breath. Poor appetite or weight loss. Muscle and joint aches. […] Without treatment, endocarditis is a fatal disease. […] Endocarditis is fatal without treatment.

• #2 Endocarditis > Fact Sheets > Yale Medicine

  https://www.yalemedicine.org/conditions/endocarditis

  Symptoms include fever, nausea, vomiting, fatigue, muscle and joint pain […] People with bacterial or fungal endocarditis known collectively as infective endocarditis typically have flu-like symptoms, including fever, sweats, chills, and fatigue. Other symptoms may also develop, such as tiny red spots on the skin, blood under the fingernails, or blood in the urine. […] Symptoms of endocarditis may include: Fever, Chills, Night sweats, Fatigue, Joint and muscle pain, Loss of appetite, Shortness of breath, Weight loss, Chest pain, Blood in urine, Small, red spots on the palms and soles, Thin lines of blood under the nails, Painful, reddish bumps on fingers and toes. […] People with noninfective endocarditis often don’t have any symptoms, though some may have shortness of breath or heart palpitations.

• #2 Endocarditis – causes, symptoms and treatments – BHF

  https://www.bhf.org.uk/informationsupport/conditions/endocarditis

  The symptoms of endocarditis can be hard to notice and unclear, developing slowly over weeks or sometimes months. In some cases, however, they can develop suddenly. […] The most common symptoms of endocarditis are: flu-like symptoms these include having a temperature, tiredness, headaches, chills, a cough and sore throat, poor appetite or unexplained weight loss, pale skin, aching muscles and joints, heart murmurs (an abnormal heart sound). […] Other rarer symptoms you may see or feel include: small dark-coloured spots on the skin, unusual dark lines under your fingernails, red lumps on the fingers or toes that might be painful. […] If you’ve been told you’re at high risk of developing endocarditis and you have flu-like symptoms with a high temperature for more than a week, see your GP immediately.

• #2 Endocarditis | Infective Endocarditis | IE | MedlinePlus

  https://medlineplus.gov/endocarditis.html

  Endocarditis symptoms may be severe or very mild. They may start suddenly or slowly. And they can vary from person to person. The possible symptoms of endocarditis include: […] Fever and chills […] New or worsening heart murmur (an unusual sound heard between heartbeats) […] Chest pain […] Cough […] Muscle, joint, and back pain […] Night sweats (heavy sweating during sleep) […] Shortness of breath (feeling like you can’t get enough air) […] Skin changes, including: […] Broken blood vessels […] Painful red or purple bumps […] Painless flat red spots on the palms of your hands or soles of your feet.

• #2 Endocarditis: Symptoms & Causes | NewYork-Presbyterian

  https://www.nyp.org/heart/heart-inflammation/endocarditis

  Endocarditis is inflammation of the inner lining and valves of the heart; it is usually caused by a bacterial or fungal infection originating somewhere else in the body. Endocarditis is serious and if left untreated, can be fatal. […] Signs and symptoms of endocarditis can differ between people. An existing heart condition could significantly increase the chance of contracting endocarditis. The type of germ causing the initial infection would indicate the type of inflammation present. Some common endocarditis symptoms may include: Joint and muscle pain, Shortness of breath and chest pain when breathing, Fatigue, Fever, chills, and flu-like symptoms, Night sweats, Swelling in the legs, feet, and stomach due to fluid retention, A newly developed or changed heart murmur. […] Some fewer common signs of endocarditis could include: Weight loss, Blood in the urine, Tenderness near the spleen (under the left rib cage), Painless red, purple, or brown spots on the soles of the feet or palms of the hands (Janeway lesions), Painful red, purple, or dark patches or bumps on the tips of the fingers or toes (Osler nodes), Purple, red, or brown spots on the skin, the whites of the eyes, or inside the mouth.

• #2 Heart Inflammation – Endocarditis | NHLBI, NIH

  https://www.nhlbi.nih.gov/health/heart-inflammation/endocarditis

  Symptoms of endocarditis may develop slowly, or they may start suddenly. Symptoms can vary from mild to severe. Common symptoms of endocarditis include: […] Fever […] Heart murmur or abnormal heart sounds […] Fatigue […] Heart problems like heart valve regurgitation and heart failure […] Blood in the urine […] A spleen that is larger than normal […] Stomach pain […] Chest pain […] Cough, with or without the presence of blood […] Loss of appetite and weight loss […] Muscle, joint, and back pain […] Night sweats […] Pain at the spot of a cardiac device, such as a pacemaker, which may mean it is infected […] Shortness of breath […] Skin changes, which may be tiny reddish-purple spots from broken blood vessels, red or purple bumps, or flat red spots on your palms or the soles of the feet.

• #2

  https://www.nhs.uk/conditions/endocarditis/symptoms/

  The symptoms of endocarditis can develop rapidly over a few days (acute endocarditis), or slowly over a few weeks or possibly months (subacute endocarditis). […] The most common symptoms of endocarditis include: a high temperature, chills, night sweats, headaches, shortness of breath, especially during physical activity, cough, tiredness (fatigue), muscle and joint pain. […] Other symptoms can include: small red, brown or purple spots on the skin (petechiae); these may be harder to see on brown and black skin, narrow, reddish-brown lines of blood that run underneath the nails, painful red lumps in the pads of the fingers and toes, but redness can be harder to see on brown and black skin, painless red spots on the palms and soles, but redness can be harder to see on brown and black skin, confusion, loss of appetite, unexpected weight loss. […] Contact your GP as soon as possible if you develop any symptoms of endocarditis, particularly if you’re at a higher risk of developing it, such as if you have a history of heart disease.

• #2 Endocarditis: Symptoms, causes, treatments, and more

  https://www.medicalnewstoday.com/articles/151016

  Endocarditis, or infective endocarditis, is a rare infection of the inner lining of the hearts chambers and valves. It is a serious condition that requires immediate medical attention, but it is treatable with antibiotics. […] The condition may cause someone to develop a fever or shortness of breath. Prompt treatment is necessary to prevent potentially serious complications. […] Fever is the most common symptom of endocarditis. Other common symptoms include: chills, night sweats, malaise, which refers to generally feeling unwell, headache, shortness of breath, coughing, muscle or joint pain. […] Endocarditis can also cause: unexplained weight loss, loss of appetite, Osler nodes, which are bumps that develop on the fingers, Janeway lesions, which are small painless spots that form on the palms or soles of feet, sharp chest pain that worsens when breathing, heart murmurs, congestive heart failure, petechiae, which are small red dots on the skin, splinter hemorrhages, which are reddish-brown streaks of blood under the fingernail.

• #2 Signs and Symptoms

  http://www.cardiosmart.org/topics/endocarditis/signs-and-symptoms

  The most common symptoms of Endocarditis are: Fever, Chills, Sweats, General malaise. […] Your doctor also may identify a new or worsening heart murmur. If your heart valve is significantly affected, you may have shortness of breath and other symptoms of congestive heart failure. Endocarditis involving valves on the left side the heart (aortic and mitral valves) may cause a stroke. This can occur if parts of the infection break off the valve and travel to the brain. Signs and symptoms of stroke include a sudden change in vision, speech, movement, or consciousness. Some patients have symptoms that go on for a while or are vague. This is called subacute endocarditis. […] Other signs and symptoms include dark marks on the palms and soles, or painful red marks on the hands and feet.

• #2 Endocarditis Guide: Causes, Symptoms and Treatment Options

  https://www.drugs.com/health-guide/endocarditis.html

  Symptoms of acute endocarditis include: high fever, chest pain, shortness of breath, cough, extreme fatigue. […] Symptoms of subacute endocarditis include: low-grade fever (less than 102.9° Fahrenheit), chills, night sweats, pain in muscles and joints, a persistent tired feeling, headache, shortness of breath, poor appetite, weight loss, small, tender nodules on the fingers or toes, tiny broken blood vessels on the whites of the eyes, the palate, inside the cheeks, on the chest, or on the fingers and toes. […] Symptoms of acute endocarditis usually begin suddenly and get worse quickly. It is an infection that can develop dramatically over a few days. Subacute endocarditis develops more slowly, and its milder symptoms can be present for weeks or months before the illness is suspected.

• #2 Infective endocarditis | Heart and Stroke Foundation

  https://www.heartandstroke.ca/heart-disease/conditions/infective-endocarditis

  The symptoms of endocarditis can develop over days or weeks depending on a persons health and other disease factors. Common symptoms are: fever, chills, weakness, fatigue, aching joints and muscles, night sweats, shortness of breath, paleness, persistent cough, swelling in the feet, legs or abdomen. […] Less common symptoms include: unexplained weight loss, blood in your urine, a new heart murmur, tenderness in the spleen, bleeding under the nails, flat, painless spots on the palms of your hands and soles of feet (Janeway lesions), painful, red bumps on the pads of the fingers and toes (Oslers nodes), small red spots on the skin, whites of the eyes or mouth (petechiae).

• #2 Endocarditis Information | Mount Sinai – New York

  https://www.mountsinai.org/health-library/diseases-conditions/endocarditis

  Endocarditis is inflammation of the inside lining of the heart chambers and heart valves (endocardium). It is most often caused by a bacterial or, rarely, a fungal infection. […] Symptoms of endocarditis may develop slowly or suddenly. Fever, chills, and sweating are frequent symptoms. These sometimes can: Be present for days before any other symptoms appear, Come and go, or be more noticeable at nighttime. […] You may also have fatigue, weakness, weight loss, loss of appetite, and aches and pains in the muscles or joints. Other signs can include: Small areas of bleeding under the nails (splinter hemorrhages), Red, painless skin spots on the palms and soles (Janeway lesions), Red, painful nodes in the pads of the fingers and toes (Osler nodes), Shortness of breath with activity, Swelling of feet, legs, abdomen.

• #2 Heart Valve Infection (Endocarditis): Symptoms, Treatment and Prevention

  https://www.webmd.com/heart-disease/what-is-endocarditis

  If you develop endocarditis, you may get sudden symptoms, or you may develop them over time. The way you feel will depend on how healthy your heart is and what caused your infection. The symptoms can also vary from person to person but may include: […] Signs of endocarditis may develop slowly or all of a sudden. They include: Fever, chills, and sweating that last a long time or come and go and may be more pronounced at night. Swelling in the legs, feet, or abdomen. Tiredness and weakness. Appetite loss and weight loss. Achy muscles or joints. Bleeding under the nails (splinter hemorrhages). Painless red areas on your palms or the bottom of your feet. Painful red lumps on the pads of your fingers or toes.

• #2 Infective Endocarditis Clinical Presentation: History, Physical Examination, Complications

  https://emedicine.medscape.com/article/216650-clinical

  The symptoms of early subacute native valve endocarditis (NVE) usually are subtle and nonspecific. They include low-grade fever (absent in 3-15% of patients), anorexia, weight loss, influenzalike syndromes, polymyalgia-like syndromes, pleuritic pain, syndromes resembling rheumatic fever (eg, fever, dulled sensorium as in typhoid, headaches), and abdominal symptoms (eg, right upper quadrant pain, vomiting, postprandial distress, appendicitis-like symptoms). […] When appropriate therapy is delayed for weeks or months, additional clinical features, embolic or immunologic in origin, develop. […] The origin of lumbosacral back pain in patients with subacute IE (15%) is unclear but probably results from the deposition of immune complexes in the disk space; however, antibiotic therapy rapidly abolishes these symptoms.

• #2 Endocarditis – Wikipedia

  https://en.wikipedia.org/wiki/Endocarditis

  Signs and symptoms include fever, chills, sweating, malaise, weakness, anorexia, weight loss, splenomegaly, flu-like feeling, cardiac murmur, heart failure, petechia (red spots on the skin), Osler’s nodes (subcutaneous nodules found on hands and feet), Janeway lesions (nodular lesions on palms and soles), and Roth’s spots (retinal hemorrhages). […] Symptoms may include fever, small areas of bleeding into the skin, heart murmur, feeling tired, and low red blood cells. […] The risk of death among those infected is about 25%. […] Without treatment it is almost universally fatal.

• #2 Endocarditis Information | Mount Sinai – New York

  https://www.mountsinai.org/health-library/diseases-conditions/endocarditis

  Getting treatment for endocarditis right away improves the chances of a good outcome. More serious problems that may develop include: Brain abscess, Further damage to the heart valves, causing heart failure, Spread of the infection to other parts of the body, Stroke, caused by small clots or pieces of the infection breaking off and traveling to the brain.

• #2 Pediatric Endocarditis Symptoms & Treatment | Lurie Children’s

  https://www.luriechildrens.org/en/specialties-conditions/endocarditis/

  Neurological problems, including strokes, may occur in people with endocarditis. This is due to debris from the inflammation flipping off the valves and going through the blood stream to the brain. […] Occasionally, there is inflammation of the electrical system of the heart (conduction system) which may cause rhythm abnormalities or heart block.

• #2 Infective Endocarditis (IE): Causes, Symptoms & Treatment

  https://my.clevelandclinic.org/health/diseases/23068-infective-endocarditis

  Infective endocarditis symptoms often affect your heart and respiratory system. You may experience: […] Additional symptoms may include: […] When not detected early, bacteria grow and spread, leading to complications such as heart failure. […] You may also experience emboli when initial treatments aren’t successful. These small clots of bacterial colonies can travel through your bloodstream. If they block a blood vessel, emboli can cause additional, sometimes life-threatening complications because they block the blood supply to vital organs. […] Without early, aggressive antibiotic therapy, the prognosis for this condition is poor. People who receive timely infective endocarditis treatment have the best chances for survival. Complications can slow your recovery.

• #2 Infective endocarditis – Wikipedia

  https://en.wikipedia.org/wiki/Infective_endocarditis

  Signs and symptoms may include fever, small areas of bleeding into the skin, heart murmur, feeling tired, and low red blood cell count. […] Complications may include backward blood flow in the heart, heart failure the heart struggling to pump a sufficient amount of blood to meet the body’s needs, abnormal electrical conduction in the heart, stroke, and kidney failure. […] Infective endocarditis occurs in males more often than in females. […] The risk of death among those infected is about 25%. […] Without treatment, it is almost universally fatal. […] Improved diagnosis and treatment options have significantly enhanced the life expectancy of patients with infective endocarditis, particularly with congenital heart disease. […] Infective endocarditis is associated with 18% in-hospital mortality. […] However, adult patients with congenital heart disease can have relatively lower mortality down to 5% due to younger age, right-sided endocarditis and management by multidisciplinary teams. As many as 50% of people with infective endocarditis may experience embolic complications.

• #2

  https://myhealth.alberta.ca/Health/pages/conditions.aspx?hwid=hw164664

  Symptoms may appear quickly, within a few days of infection. In other cases, they may develop more slowly. The symptoms will get worse as the bacteria or fungi grow in your heart. […] Symptoms may include: Flu-like symptoms such as fever, chills, night sweats, and fatigue. These are often the first symptoms. Weight loss. Muscle or joint pain. Cough. Shortness of breath. Blood under the fingernails or tiny purple and red spots under the skin. […] If endocarditis isn’t treated soon, it can lead to more serious problems, such as: Heart failure. An abscess in the heart. Heart rhythm problems. Heart attack or stroke. Infections in other organs, such as the lungs, brain, or kidneys.

• #2 Endocarditis: Symptoms, Testing, and Treatment | MyHeartDiseaseTeam

  https://www.myheartdiseaseteam.com/resources/endocarditis-symptoms-testing-and-treatment

  Endocarditis usually causes a fever in addition to other symptoms. Some people will experience only mild symptoms, while others will have more severe health changes. Sometimes, people mistake endocarditis for another condition that causes similar symptoms, such as the flu. […] Symptoms of endocarditis may include: Fever, chills, or night sweats, Tiredness, Rash, Sore throat, Stuffy nose, Headaches, Soreness or tenderness near the cheekbones, Persistent cough, Chest pain when breathing, Shortness of breath, Muscle aches, pains, or weakness, Wounds or sores that are red or discolored, drain pus, or dont heal, White areas inside of the mouth, Nausea, vomiting, diarrhea, or abdominal bloating, Unexpected weight loss. […] In some cases, endocarditis can also cause pain on the upper left side of the abdomen or blood in the urine. Brown, purple, or red nodules or spots especially on the palms, fingers, soles of the feet, or toes (called Osler nodes and Janeway lesions) may also be a symptom of the condition. […] If youre at high risk of endocarditis and experience symptoms, contact your doctor immediately. Without treatment, endocarditis may lead to an irregular heartbeat, heart failure, stroke, sepsis (a serious reaction in which multiple organs become damaged or shut down), or even death.

• #2 Recognizing Endocarditis Symptoms Early

  https://www.everydayhealth.com/heart-health/endocarditis-symptoms/

  If you have been diagnosed with endocarditis, the following symptoms can signal the condition is getting worse: Fever, Chills, Shortness of breath, Headache, Joint pain. […] Endocarditis can cause flu-like symptoms in addition to swelling, skin rash, and other skin conditions like discoloration and bumps on the hands and feet. These symptoms can also be signs of less serious infections and conditions, but since endocarditis can quickly turn fatal if not treated, its important to get them checked out.

• #2 What Is Endocarditis? Learn Causes, Symptoms & Treatment – BuzzRx

  https://www.buzzrx.com/blog/what-is-endocarditis

  Acute infective endocarditis begins suddenly and can become life-threatening within days. It is associated with severe symptoms of endocarditis and serious complications such as stroke, pulmonary embolism (blood clots in the lungs), sepsis, heart attacks, and heart failure. […] Subacute infective endocarditis tends to develop slowly over several weeks to months. It causes nonspecific symptoms such as fever, chills, night sweats, trouble breathing, and muscle aches. Diagnosis of subacute endocarditis is often delayed due to the endocarditis symptoms being nonspecific.

• #2 Endocarditis: Symptoms, Causes, Management (Orange County)

  https://www.hoag.org/specialties-services/heart-vascular/specialty-programs/heart-failure-program/conditions/endocarditis/

  The symptoms of endocarditis can vary depending on the cause and severity of the condition. In cases of acute endocarditis, symptoms can develop quickly over the course of a few days. In cases of subacute endocarditis, which is more common in those with congenital heart disease, symptoms can develop over the course of weeks or even months. […] Generally, the most common symptoms of endocarditis are: Flu-like symptoms, which may include fever, chills, unusual fatigue, a persistent aching in the muscles, night sweats or headaches, Persistent coughing, Shortness of breath, particular during physical activity. […] Other, less common symptoms of endocarditis include: Sudden, unexplained loss of appetite, Unexpected weight loss, Confusion, Painless red spots on the soles of the feet or the palms of the hands, Painful red lumps on the fingers or toes, Narrow, reddish-brown lines of blood visible beneath the fingernails, Petechiae, which are small red, brown or purple spots on the skin.

• #2 Endocarditis – causes, symptoms and treatments – BHF

  https://www.bhf.org.uk/informationsupport/conditions/endocarditis

  Infective endocarditis can be fatal if left untreated. Therefore, early detection and prompt management are critically important. […] You should contact your healthcare provider as soon as possible if you recognise the above symptoms. This is especially important if you’re at higher risk of developing endocarditis, such as having a history of heart valve disease.

• #2 What Is Endocarditis? Learn Causes, Symptoms & Treatment – BuzzRx

  https://www.buzzrx.com/blog/what-is-endocarditis

  Common Symptoms of Endocarditis include flu-like symptoms (fever and chills), night sweats, fatigue, skin rash, draining skin sores, redness, pain, tenderness, and swelling, aching joints and muscles, cuts and wounds that won’t heal properly, scratchy throat, sore throat, pain with swallowing, dry or wet cough that persists for more than 2 days, nasal congestion, sinus drainage, headaches, tenderness along the cheekbones, white patches on the tongue or mouth, shortness of breath, chest pain with breathing, swelling in the feet, legs, or abdomen, nausea, vomiting, diarrhea, loss of appetite, and weight loss. […] Serious Endocarditis Symptoms Requiring Immediate Attention include any signs and symptoms of infective endocarditis, especially if you have a history of heart valve disease, artificial heart valves, or a congenital heart defect. This is a serious life-threatening condition, and endocarditis symptoms can resemble other less serious conditions. Only a healthcare provider can make a proper diagnosis and offer appropriate treatment.

• #2 Endocarditis > Fact Sheets > Yale Medicine

  https://www.yalemedicine.org/conditions/endocarditis

  Endocarditis can affect people of any age, though it’s most common in older adults. It’s a serious condition; if left untreated, endocarditis can lead to heart failure, stroke, heart attack, and even death. […] Because endocarditis is a life-threatening condition with a risk of serious complications, it’s essential that people who develop symptoms seek treatment right away. Early treatment can stop disease progression and limit damage to the heart and heart valves.

• #2 Endocarditis: Symptoms, causes, treatments, and more

  https://www.medicalnewstoday.com/articles/151016

  Without prompt treatment, endocarditis may cause serious heart damage or death. A person needs to speak with a doctor immediately if they notice any signs of endocarditis. […] The mortality rate of endocarditis is around 20% within 30 days of infection. A person is unlikely to survive without antibiotics. […] Endocarditis can cause symptoms such as fever, chills, night sweats, and shortness of breath. If a person develops symptoms of endocarditis, they need to seek immediate medical advice. Without prompt treatment, it can cause serious heart damage or death. […] Most people recover from endocarditis. Receiving an early diagnosis and beginning antibiotic treatment as early as possible can help improve a persons outlook.

• #2 Infective endocarditis – Cardiology Explained – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK2208/

  An acute confusional state is common in patients with infective endocarditis (IE). Cerebral emboli, which usually affect the middle cerebral artery, result in hemiplegia and sensory dysfunction. […] Infarction causes loin pain and hematuria. Immune complex deposition may result in glomerulonephritis. […] If any of these signs occur together with a fever, the patient should be urgently referred to a cardiologist for blood cultures and echocardiography the level of risk will determine whether this is transesophageal echo (TEE) or transthoracic echo. […] The Duke diagnostic classification for IE divides signs and symptoms into major and minor criteria. IE is diagnosed if patients have: two major criteria; or one major and three minor criteria; or five minor criteria. […] With effective treatment, patients with IE have a 70% survival rate. The prognosis is worse if there is no identifiable organism or if there is a resistant organism. Fungal infections are associated with increased mortality, as is prosthetic valve endocarditis. Overall death rates are 20% for native valve endocarditis, 30% for staphylococcal infections, and 20%30% for late prosthetic valve infection, despite full medical and surgical treatment. The most common cause of death is intractable heart failure.

• #2

  https://111.wales.nhs.uk/encyclopaedia/e/article/endocarditis/

  Other symptoms can include: small red or purple spots on the skin (petechiae); these may be harder to see on brown and black skin, narrow, reddish-brown lines of blood that run underneath the nails, painful red lumps in the pads of the fingers and toes, painful red spots on the palms and soles, confusion, loss of appetite, unexpected weight loss. […] Endocarditis is a serious illness, especially if complications develop. Early diagnosis and treatment is vital to improve the outlook for the condition.

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