Zapalenie przełyku
Zapobieganie i profilaktyka

Zapalenie przełyku (oesophagitis) to stan zapalny błony śluzowej przełyku, wywołany m.in. przez refluks kwasu żołądkowego, infekcje, substancje drażniące czy reakcje alergiczne. Objawy obejmują dysfagię, ból przy przełykaniu, zgagę i ból w klatce piersiowej. Nieleczone może prowadzić do powikłań takich jak zwężenie przełyku czy przełyk Barretta. Profilaktyka obejmuje modyfikacje stylu życia: utrzymanie prawidłowej masy ciała, unikanie posiłków na 3 godziny przed snem, uniesienie wezgłowia łóżka o 15-20 cm, zaprzestanie palenia i ograniczenie alkoholu. Dieta powinna eliminować pokarmy nasilające refluks (ostre, kwaśne, tłuste, kofeinowe, alkohol, czekolada, mięta, warzywa krzyżowe, mleko). W przypadku zapalenia indukowanego lekami zaleca się przyjmowanie ich w pozycji pionowej z co najmniej 200-250 ml wody oraz pozostanie w pozycji pionowej przez 10-15 minut po podaniu.

Definicja zapalenia przełyku

Zapalenie przełyku (łac. oesophagitis) to stan zapalny błony śluzowej przełyku, który może być spowodowany różnymi czynnikami, takimi jak refluks kwasu żołądkowego, infekcje, działanie substancji drażniących czy reakcje alergiczne. Stan ten charakteryzuje się objawami takimi jak ból przy przełykaniu, zgaga, ból w klatce piersiowej czy trudności w połykaniu. Nieleczone zapalenie przełyku może prowadzić do poważniejszych powikłań, w tym zwężenia przełyku czy przełyku Barretta.1

Profilaktyka zapalenia przełyku

Niektóre rodzaje zapalenia przełyku można skutecznie zapobiegać poprzez odpowiednie modyfikacje stylu życia i diety. Działania profilaktyczne różnią się w zależności od przyczyny zapalenia przełyku.12

Modyfikacje stylu życia

Wdrożenie odpowiednich zmian w stylu życia ma kluczowe znaczenie w profilaktyce zapalenia przełyku, szczególnie w przypadku zapalenia przełyku związanego z chorobą refluksową przełyku (GERD):12

  • Utrzymywanie prawidłowej masy ciała – nadwaga i otyłość zwiększają ryzyko refluksu żołądkowo-przełykowego poprzez zwiększenie ciśnienia w jamie brzusznej12
  • Unikanie posiłków na 3 godziny przed snem – spożywanie posiłków tuż przed położeniem się do łóżka zwiększa ryzyko refluksu12
  • Uniesienie wezgłowia łóżka o 15-20 cm (6-8 cali) – można to osiągnąć poprzez umieszczenie specjalnych bloków pod nóżkami łóżka od strony głowy lub zastosowanie specjalnych klinów pod materac12
  • Unikanie zginania się lub schylania bezpośrednio po posiłku1
  • Zaprzestanie palenia tytoniu – palenie osłabia dolny zwieracz przełyku i zwiększa wydzielanie kwasu żołądkowego12
  • Ograniczenie lub zaprzestanie spożywania alkoholu12
  • Zwiększenie aktywności fizycznej – regularna, umiarkowana aktywność fizyczna może pomóc w utrzymaniu prawidłowej masy ciała i poprawić funkcjonowanie przewodu pokarmowego12
  • Spożywanie mniejszych porcji posiłków, ale częściej – duże posiłki mogą zwiększać ciśnienie w żołądku i sprzyjać refluksowi12

Modyfikacje diety

Odpowiednie zmiany w diecie mogą znacząco zmniejszyć ryzyko wystąpienia lub nawrotu zapalenia przełyku:12

  • Unikanie pokarmów i napojów mogących nasilać objawy refluksu:
    • Potrawy ostre i kwaśne (np. cytrusy, pomidory)12
    • Tłuste i smażone pokarmy12
    • Napoje zawierające kofeinę (kawa, herbata, napoje gazowane)12
    • Czekolada i wyroby zawierające miętę12
    • Napoje alkoholowe12
    • Duże ilości suplementów witaminy C1
    • Warzywa krzyżowe (cebula, kapusta, kalafior, brokuły, szpinak, brukselka)1
    • Mleko i produkty mleczne1
  • Przyjmowanie mniejszych porcji posiłków1
  • Spożywanie pokarmów o łagodniejszej konsystencji podczas leczenia zapalenia przełyku12
  • Staranne żucie pokarmów przed połknięciem12
  • Identyfikacja alergenów pokarmowych i ich unikanie (szczególnie w przypadku eozynofilowego zapalenia przełyku)12

Prawidłowe przyjmowanie leków

Nieprawidłowe przyjmowanie leków może prowadzić do zapalenia przełyku wywołanego przez leki (pill-induced esophagitis). Aby temu zapobiec, należy przestrzegać następujących zasad:12

  • Przyjmowanie leków w pozycji siedzącej lub stojącej12
  • Przyjmowanie leków z wystarczającą ilością wody (co najmniej 200-250 ml)12
  • Unikanie przyjmowania leków bezpośrednio przed snem12
  • Pozostanie w pozycji pionowej przez co najmniej 10-15 minut po przyjęciu leków12
  • Spożycie posiłku po przyjęciu leku – pokarm może pomóc w przełknięciu i trawieniu leku12
  • Przyjmowanie leków pojedynczo, a nie wszystkich naraz12
  • Rozważenie alternatywnych form leków (np. preparaty płynne) w przypadku wąskiego przełyku1
  • Konsultacja z lekarzem w sprawie zmiany leków, które mogą drażnić przełyk12

Profilaktyka w zależności od typu zapalenia przełyku

Refluksowe zapalenie przełyku

W przypadku refluksowego zapalenia przełyku, oprócz wyżej wymienionych modyfikacji stylu życia i diety, można rozważyć stosowanie leków zmniejszających wydzielanie kwasu żołądkowego:12

Zakaźne zapalenie przełyku

Zakaźne zapalenie przełyku występuje głównie u osób z obniżoną odpornością. Działania profilaktyczne obejmują:12

  • Unikanie kontaktu z osobami zarażonymi, szczególnie w przypadku osób z osłabionym układem odpornościowym12
  • Utrzymywanie prawidłowej higieny jamy ustnej, co może zapobiegać zapaleniu przełyku wywołanemu przez drożdżaki Candida12
  • Unikanie sytuacji powodujących immunosupresję lub niszczących skład normalnej flory bakteryjnej (np. długotrwała terapia antybiotykami o szerokim spektrum działania)1
  • W przypadku zakażenia wirusem HSV, zmniejszanie ryzyka transmisji wirusa poprzez:1
    • Stosowanie barierowych metod ochrony (prezerwatywy, chusty lateksowe) podczas aktywności seksualnej
    • Unikanie kontaktu usta-usta i seksu oralnego podczas wystąpienia opryszczki wargowej
    • Niepodzielanie się przedmiotami, które miały kontakt z ustami podczas wystąpienia opryszczki wargowej
    • Unikanie kontaktu seksualnego podczas wystąpienia opryszczki narządów płciowych
    • Niedotykanie żadnych zmian podczas wystąpienia opryszczki

Alergiczne i eozynofilowe zapalenie przełyku

W przypadku eozynofilowego zapalenia przełyku (EoE) i alergicznego zapalenia przełyku, działania profilaktyczne koncentrują się na identyfikacji i unikaniu alergenów:12

  • Identyfikacja alergenów pokarmowych i środowiskowych z pomocą alergologa12
  • Eliminacja zidentyfikowanych alergenów z diety1
  • W niektórych przypadkach stosowanie kortykosteroidów zgodnie z zaleceniami lekarza1

Należy zaznaczyć, że według aktualnej wiedzy, eozynofilowego zapalenia przełyku nie można całkowicie zapobiec, ponieważ przyczyny i czynniki ryzyka nie zostały jeszcze dokładnie wyjaśnione.1

Żrące zapalenie przełyku

Żrące zapalenie przełyku jest często wynikiem przypadkowego połknięcia substancji żrących. Działania profilaktyczne obejmują:12

  • Przechowywanie substancji żrących w bezpiecznym miejscu, poza zasięgiem dzieci
  • Utrzymywanie substancji chemicznych w oryginalnych, zamkniętych pojemnikach
  • Odpowiednie oznakowanie butelek zawierających szkodliwe substancje

Farmakologiczna profilaktyka zapalenia przełyku

Profilaktyka zapalenia przełyku wywołanego przez radioterapię

Zapalenie przełyku indukowane radioterapią jest częstym ostrym działaniem niepożądanym w trakcie radioterapii nowotworów klatki piersiowej i szyi. Należy zauważyć, że obecnie nie istnieją skuteczne środki profilaktyczne dla tego rodzaju zapalenia przełyku.1

Badania nad zastosowaniem glutaminy doustnej w profilaktyce ostrego popromiennego zapalenia przełyku u pacjentów z nowotworami płuc leczonych radioterapią klatki piersiowej przyniosły sprzeczne wyniki:12

  • Niektóre badania sugerują, że glutamina doustna może zmniejszać nasilenie popromiennego zapalenia przełyku1
  • Inne badania nie wykazały znaczącej poprawy w zakresie ciężkości ostrego popromiennego zapalenia przełyku, utraty masy ciała, specyficznych objawów głowy i szyi lub zakłóceń objawowych w porównaniu z placebo1

Profilaktyka zapalenia przełyku po zabiegach endoskopowych

U kotów, a przez analogię potencjalnie także u ludzi, niektórzy lekarze stosują inhibitory pompy protonowej lub środki prokinetyczne profilaktycznie przed każdym zabiegiem endoskopowym w celu zapobiegania refluksowemu zapaleniu przełyku. Alternatywnie, można podawać zawiesinę sukralfatu po indukcji znieczulenia w celu zapewnienia ochrony przed refluksem treści żołądkowej.12

Znaczenie wczesnego rozpoznania i leczenia

Ważnym aspektem profilaktyki zapalenia przełyku jest wczesne rozpoznanie i leczenie, co może zapobiec rozwojowi poważniejszych powikłań:12

  • Wczesne zgłaszanie objawów lekarzowi i szybkie rozpoczęcie leczenia może zapobiec rozwojowi cięższego zapalenia1
  • Odpowiednie leczenie choroby refluksowej przełyku może zapobiec rozwojowi przełyku Barretta12
  • Zapalenie przełyku powinno być leczone jak najwcześniej, ponieważ przedłużający się stan zapalny może prowadzić do zwężenia przełyku w wyniku tworzenia się tkanki bliznowatej1
  • Właściwe leczenie może zapobiec nawrotom i zmniejszyć ryzyko powikłań12

Podsumowanie działań profilaktycznych

Profilaktyka zapalenia przełyku obejmuje szereg działań, które można dostosować do konkretnej przyczyny tego schorzenia:12

  • Modyfikacje stylu życia – utrzymywanie prawidłowej masy ciała, unikanie posiłków przed snem, uniesienie wezgłowia łóżka, zaprzestanie palenia tytoniu i ograniczenie spożycia alkoholu12
  • Modyfikacje diety – identyfikacja i unikanie pokarmów wyzwalających objawy, spożywanie mniejszych posiłków, dokładne żucie pokarmów12
  • Prawidłowe przyjmowanie leków – przyjmowanie leków w pozycji pionowej, z wystarczającą ilością wody, unikanie przyjmowania leków przed snem12
  • Profilaktyka farmakologiczna – w niektórych przypadkach stosowanie leków zmniejszających wydzielanie kwasu żołądkowego, leków ochronnych lub melatoniny12
  • Profilaktyka zakaźnego zapalenia przełyku – utrzymywanie dobrej higieny jamy ustnej, unikanie kontaktu z osobami zarażonymi, zwłaszcza w przypadku osłabionego układu odpornościowego12
  • Wczesne rozpoznanie i leczenie – ścisłe przestrzeganie zaleceń lekarza dotyczących przyjmowania leków i modyfikacji stylu życia12

Należy podkreślić, że zapalenie przełyku może nawracać, dlatego istotne jest przestrzeganie zaleceń lekarza dotyczących zmian stylu życia i stosowania leków.12

Kolejne rozdziały

Zapraszamy do dalszego czytania naszego leksykonu.

Wybierz kolejny rozdział z menu poniżej, aby otworzyć nową podstronę kompedium wiedzy i uzyskać szczegółowe informację o leku, substancji lub chorobie.

  1. 09.04.2026
  2. www.leksykon.com.pl

Materiały źródłowe

  • #1 Coping Strategies for Esophagitis | Austin Gastroenterology
    https://www.austingastro.com/2021/09/24/coping-strategies-for-esophagitis/
    Esophagitis happens when your esophagus is inflamed. […] You need to control esophagitis early on to prevent it from developing into more severe conditions like Barrett’s esophagus. […] The prevention of acid reflux is one of the strategies for preventing and dealing with esophagitis. […] You should avoid foods that are spicy and acidic. […] Some people also experience esophagitis due to food allergies. […] Sometimes, certain types of drugs can also cause esophagitis. […] Quitting smoking and limiting alcohol intake can help you cope with this condition. […] Poor eating and swallowing habits can also worsen symptoms of esophagitis. […] You can also control your symptoms of esophagitis by eating softer foods. […] Overall, you should consider developing better digestive health habits.
  • #1 Esophagitis: Symptoms & Treatment
    https://www.medicinenet.com/esophagitis/article.htm
    Can esophagitis be prevented? […] Some types of esophagitis can be prevented. […] Esophagitis caused by GERD may be prevented by changes in lifestyle and diet. […] Proper oral hygiene can aid in the prevention of esophagitis caused by Candida yeast. […] Take all pills with plenty of water, and in an upright position.
  • #1 Esophagitis Guide: Causes, Symptoms and Treatment Options
    https://www.drugs.com/health-guide/esophagitis.html
    The most common cause of esophagitis, acid reflux, sometimes can be prevented by some very simple measures: […] Avoid heavy meals, especially within several hours of bedtime. […] Cut out cigarettes and alcohol. […] Avoid large amounts of caffeine, chocolate, peppermint, and high-fat foods. […] Control your weight. […] If you have heartburn despite these measures, your doctor may suggest you take a preventive acid-blocking medicine. […] All prescription and nonprescription pills should be taken while you are upright and should be swallowed with water. This is especially important for the medicines that frequently cause esophagitis.
  • #1 Esophagitis – StatPearls – NCBI Bookshelf
    https://www.ncbi.nlm.nih.gov/books/NBK442012/
    Lifestyle and dietary modifications are important parts of treatment and further prevention of esophagitis. Patient with Acid reflux esophagitis who are overweight should try for weight loss. Common dietary triggers and habits which include fatty and spicy meals, coffee, carbonated drinks, spicy food, chocolate, alcohol, smoking and not keeping enough time between dinner and bedtime should be avoided. The elevating head end of the bed to 30-45 degree can help with nocturnal symptoms of acid reflux include night cough, sore throat and voice hoarseness. Patient diagnosed with EoE should avoid foods they are allergic to. Maintenance of small meals, clear liquid or soft puree diet during treatment can help with symptoms and accelerate healing time.[15] […] To avoid delay in diagnosis, an interprofessional approach is necessary. The prognosis for most patients is good with prompt treatment, but ultimately the outcomes depend on the underlying cause. When esophagitis is recurrent, it can lead to anxiety and absenteeism from work because of the need to rule out other more serious causes of chest pain.
  • #1 Esophagitis: Causes, Symptoms, & Treatments
    https://www.webmd.com/digestive-disorders/esophagitis
    To avoid getting esophagitis, or to keep it from coming back, try these tips: […] Avoid foods that are spicy, fatty, hard, or acidic, and keep caffeine, chocolate, and mint-flavored foods to a minimum. […] Try not to eat right before bedtime. […] Take small bites and chew food thoroughly. […] Avoid alcohol and tobacco. […] When you take medication, take it with plenty of water. […] Don’t take medicine lying down or right before you go to sleep. […] Ask your doctor if losing weight would help your symptoms. […] Avoid bending or stooping down right after you eat. […] Raise one end of your bed by 6-8 inches to elevate your head. You can put blocks under your bed or put a wedge between your box springs and mattress. Simply using more pillows won’t work.
  • #1 Gastroesophageal Reflux Disease (GERD) – Digestive Disorders – Merck Manual Consumer Version
    https://www.merckmanuals.com/home/digestive-disorders/esophageal-and-swallowing-disorders/gastroesophageal-reflux-disease-gerd
    Several measures may be taken to relieve gastroesophageal reflux: […] Raising the head of the bed about 6 inches (about 15 centimeters) by placing 6- to 8-inch (about 15- to 20-centimeter) blocks under the legs at the head of the bed, by using a wedge pillow, or by placing a wedge under the mattress can help prevent acid from flowing into the esophagus as a person sleeps. […] Medications that cause symptoms should be avoided, as should smoking. […] Caffeine, alcohol, fatty foods, chocolate, acid-containing beverages such as orange juice, cola drinks, vinegar-based salad dressings, and other substances that strongly stimulate the stomach to produce acid or that delay stomach emptying should be avoided as well. People should avoid eating 3 hours before bedtime. […] People who are overweight and those who have gained weight recently should lose weight.
  • #1 Esophagitis – StatPearls – NCBI Bookshelf
    https://www.ncbi.nlm.nih.gov/books/NBK442012/
    Patient education is key when a diagnosis of esophagitis is made. The patient should be told to sleep with the head of bed elevated, avoid lying supine after a meal and lose weight. The patient should also avoid caffeinated beverages, alcohol and discontinue smoking. Finally, the patient should be told to avoid NSAIDS.[16][17]
  • #1 Esophagitis
    https://inova.staywellsolutionsonline.com/YourFamily/Women/134,170
    Esophagitis can come back. You will need to follow your healthcare providers advice about lifestyle changes and medicine use. […] Your healthcare provider may advise these lifestyle changes if your condition is caused by GERD: […] Raise the head of your bed. This will help prevent reflux when you sleep. […] Change your eating habits. You may need to switch to a bland diet for a while. This means not having spicy foods, citrus, chocolate, fatty foods, or caffeine. […] Stop smoking. […] Dont drink alcohol or limit how much you drink. […] Keep a healthy weight. […] Be more active.
  • #1 Esophagitis and Stricture – Digestive and Liver Health Specialists
    https://thegidocs.com/esophagitis-and-stricture/
    Control measures and Treatment: […] Avoid eating within 3 hours of bedtime. […] Eat 5-6 small meals throughout the day rather than 3 large meals […] Avoid intense exercise, heavy weightlifting, and other strenuous activities until esophagitis is healed. […] Avoid spicy foods, fatty foods, cigarettes, chocolates, and citrus fruits. […] Elevate the head of the bed around 8-10 inches. […] Antacids: these neutralize acid and can provide comfort if heartburn or reflux symptoms are felt. […] PPIs and H2 blockers: several drugs are available to stop acid secretion, neutralize acid, and decrease inflammation. […] Surgery: there are surgical options that can be considered if medications and lifestyle changes do not lead to improvement.
  • #1 Esophagitis primary prevention – wikidoc
    https://wikidoc.org/index.php/Esophagitis_primary_prevention
    Effective primary preventive measures for esophagitis include weight loss, having head elevated while sleeping, and avoidance of certain foods that can trigger inflammation of esophagus. […] Effective primary preventive measures for esophagitis include: […] Avoidance of following foods: Coffee, Alcohol, Excessive amounts of vitamin C supplements, Foods high in fats, Smoking, Eating shortly before bedtime, Large meals, Chocolate and peppermint, Acidic foods, such as oranges and tomatoes, Cruciferous vegetables such as: onions, cabbage, cauliflower, broccoli, spinach, brussel sprouts, Milk and milk-based products.
  • #1 Esophagitis: Types, Symptoms, Causes, Diagnosis, Treatment
    https://www.health.com/esophagitis-overview-7495960
    It is not always possible to prevent esophagitis, but certain preventive measures may lower your risk of developing the condition or prevent recurrences: […] Maintain a healthy weight […] Avoid eating large meals and opt for smaller, more frequent meals […] Avoid lying down immediately after meals […] Identify and avoid trigger foods that worsen acid reflux symptoms (e.g., spicy, acidic, or fried foods, alcohol, caffeine, carbonated beverages) […] Quit smoking […] Take all medications while you are sitting or standing upright, and swallow with plenty of water […] Seek treatment for ongoing episodes of acid reflux (heartburn)
  • #1 Esophagitis: What It Is, Symptoms, Causes & Treatment
    https://my.clevelandclinic.org/health/diseases/10138-esophagitis
    Commonsense self-care. Quit smoking and avoid alcohol to protect your esophagus. […] During recovery, take care to: […] Avoid irritants in your esophagus, such as spicy and acidic foods, alcohol and smoking. […] Consider a soft diet to reduce friction in your esophagus while its healing. […] Take small bites of food and chew well before swallowing. […] Stay hydrated with water or soothing teas, such as marshmallow and slippery elm.
  • #1 Esophagitis- Causes, Diagnosis, Treatment and Prevention – Dr AvinashTank, is a super-specialist (MCh) Laparoscopic Gastro-intestinal Surgeon,
    https://dravinashtank.in/gastro_health/esophagitis-causes-diagnosis-treatment-and-prevention/
    Lifestyle changes, dietary modifications, medication management, infection prevention, allergen identification. […] Maintaining a healthy weight, avoiding smoking, and minimizing alcohol consumption can reduce the risk of developing esophagitis. […] Identifying and avoiding trigger foods that worsen symptoms can help prevent recurrent esophagitis. […] If you’re on medications that may irritate the esophagus, discuss alternatives with your healthcare provider. […] Practicing good hygiene to avoid infections that can lead to infectious esophagitis, particularly in those with weakened immune systems. […] For individuals with eosinophilic esophagitis, identifying and managing allergens through an allergist’s guidance is essential.
  • #1
    https://medcline.com/blogs/acid-reflux/pill-induced-esophagitis?srsltid=AfmBOoqQ2crj12vAZaFQbNYg-BFWiusjETyUNAsJUBEzf8EuEGwHgght
    Pill-Induced Esophagitis Prevention […] Although there are various treatments for drug-induced esophagitis, the best treatment is always prevention. Taking the proper measures to swallow your pills correctly can prevent this situation from happening all together, which is always the best case scenario. Here are a few ways to prevent pill-induced esophagitis: […] Always take your medication with enough water […] Take a pill with at least 200 to 250 ml of water […] Avoid laying down on your stomach after taking a pill […] The prone position makes it more likely that a pill will get stuck in your esophagus […] Take a pill at least 30 minutes before going to bed […] You produce less saliva and swallow less while you sleep, making it more likely that a pill can get stuck […] Eat a meal after taking a pill
  • #1 Corrosive Esophagitis – What You Need to Know
    https://www.drugs.com/cg/corrosive-esophagitis.html
    What can I do to prevent corrosive esophagitis? […] Sit or stand when you take your medicine. Do not lie down after you take your pills. Stay in an upright position for 10 to 15 minutes after you take your pills. […] Store harmful chemicals in a safe location. Label bottles with harmful substances. […] Ask for other ways to take your medicine. If you have a narrow esophagus, ask if you can take your medicine in liquid form. Ask if you can crush the pill and mix it with liquid to drink. If you must swallow pills, take them 1 at a time. Take each one with at least 4 ounces of liquid.
  • #1 Pill Esophagitis and Medication-Induced Throat Pain
    https://www.verywellhealth.com/medications-that-can-harm-the-esophagus-1943025
    Changing medications may only be part of the solution if you have pill esophagitis. There are certain habits you can adjust to help reduce the risk of future episodes. […] If you are prone to pill esophagitis, the following practical tips may help: Stand or sit upright whenever swallowing pills. Drink a sip or two of water before taking a pill. Drink an entire glass of water after taking a pill. Take your pills one at a time rather than all at once. Eat some food after taking a pill. Wait 30 minutes or longer after taking a pill before lying down.
  • #1 Esophagitis: Care Instructions | Kaiser Permanente
    https://healthy.kaiserpermanente.org/health-wellness/health-encyclopedia/he.esophagitis-care-instructions.abr9842
    If you have acid reflux, your doctor may recommend that you: […] Take stronger acid reducers. Examples are famotidine (such as Pepcid) and omeprazole (such as Prilosec). Your doctor may also prescribe acid reducers for you. […] If esophagitis is caused by an infection, you may need to take antibiotics or other medicines to treat the infection. […] If you have esophagitis caused by a food allergy, your doctor may prescribe corticosteroids.
  • #1
    https://link.springer.com/article/10.1007/s10620-005-2813-4
    Proinflammatory factors, including neutrophil-derived oxygen free radicals and inflammatory cytokines, have recently been implicated in the pathogenesis of reflux esophagitis. Rebamipide has been widely used as an anti-ulcer agent. The aim of the present study was to assess the protective effect of rebamipide against acute reflux esophagitis in rats. […] The results of this study indicate that rebamipide protects against the occurrence of esophagitis and has highly promising potential as a new therapeutic agent for reflux esophagitis.
  • #1 Melatonin in Prevention of the Sequence from Reflux Esophagitis to Barrett’s Esophagus and Esophageal Adenocarcinoma: Experimental and Clinical Perspectives
    https://www.mdpi.com/1422-0067/19/7/2033
    Melatonin, a highly lipophilic hormone, can reach body target cells rapidly, acting as the circadian signal to alter numerous physiological functions in the body. This review focused on the role played by melatonin in the mechanism of esophagoprotection, starting with its short-term protection against acute reflux esophagitis and then investigating the long-term prevention of chronic inflammation that leads to gastroesophageal reflux disease (GERD) and Barrett’s esophagus. […] The beneficial influence of melatonin in preventing esophageal injury from acid-pepsin and acid-pepsin-bile exposure in animals as well as the usefulness of melatonin and its precursor, L-tryptophan in prophylactic and supplementary therapy against esophageal disorders in humans, are also discussed. […] Melatonin acts on the target cells either directly or via G-protein coupled membrane receptors, including melatonin MT1R, MT2R and MT3R known to trigger several intracellular messengers such as cAMP, cGMP, and cytosolic Ca2+ concentration.
  • #1 Esophagitis – infectious Information | Mount Sinai – New York
    https://www.mountsinai.org/health-library/diseases-conditions/esophagitis-infectious
    If you have a weak immune system, try to avoid contact with people who have an infection with any of the organisms mentioned above. […] Many people need other long-term medicines to suppress the virus or fungus and to prevent the infection from coming back.
  • #1 Infectious esophagitis: MedlinePlus Medical EncyclopediaLock
    https://medlineplus.gov/ency/article/000646.htm
    If you have a weak immune system, try to avoid contact with people who have an infection with any of the organisms mentioned above.
  • #1 Infections of the Esophagus, Stomach, and Duodenum
    https://www.atsu.edu/faculty/chamberlain/website/lectures/lecture/gi3.htm
    Infectious esophagitis usually occurs in immunocompromised persons. […] Many different microorganisms can cause infectious esophagitis; however, the most common infectious cause of esophagitis is Candida albicans. […] Esophagitis is most common in immunocompromised patients. […] Major predisposing factors of esophagitis include antibiotic use, radiation therapy or chemotherapy, hematologic malignancies, and HIV infection. […] Patients should avoid situations that cause immunosuppression or destroy the composition of the normal flora (e.g., broad-spectrum antibiotic therapy).
  • #1 What is herpes esophagitis?: Symptoms, causes, and treatment
    https://www.medicalnewstoday.com/articles/323773
  • #1 Eosinophilic esophagitis (EoE) – USZ
    https://www.usz.ch/en/disease/eosinophilic-esophagitis/
    Eosinophilic esophagitis cannot be prevented according to current knowledge because the causes and risk factors have not yet been precisely clarified. […] There are also no targeted measures for the early detection of EoE. Always visit us promptly if you suffer from symptoms, especially swallowing disorders or pain behind the breastbone. It can also be caused by other diseases, for example reflux disease. […] Sufficient and long-term treatment can mitigate these consequences or even prevent them altogether.
  • #1 Pediatric Esophagitis Treatment & Management: Approach Considerations, Treatment of Reflux (Peptic) Esophagitis, Treatment of Corrosive (Caustic) Esophagitis
    https://emedicine.medscape.com/article/928891-treatment
    Prevention of accidental ingestion is critical, because of the potentially high associated morbidity and mortality. Corrosive agents should be locked up and kept out of reach of young children and maintained in their closed original containers.
  • #1 Therapy and prophylaxis of acute and late radiation-induced sequelae of the esophagus – PubMed
    https://pubmed.ncbi.nlm.nih.gov/9830464/
    Radiation-induced esophagitis is a frequent acute side effect in curative and palliative radiotherapy of thoracal and cervical tumors. […] There is no effective prophylactic measure for radiation esophagitis. […] Effective prophylaxis do not exist.
  • #1 The efficacy of oral glutamine in prevention of acute radiotherapy-induced esophagitis in patients with lung cancer
    https://www.termedia.pl/The-efficacy-of-oral-glutamine-in-prevention-of-acute-radiotherapy-induced-esophagitis-in-patients-with-lung-cancer,3,21747,0,1.html
    Aim of the study: This study explores the efficacy of oral glutamine in the prevention of acute radiotherapy-induced esophagitis in patients with lung cancer who are treated with thoracic radiotherapy. […] In our retrospective randomized experimental study, we determined that the severity of acute radiotherapy-induced esophagitis might be decreased with oral glutamine in patients with lung cancer who were treated with thoracic radiotherapy.
  • #1
    https://link.springer.com/article/10.1007/s10637-021-01074-w
    Oral glutamine was not associated with significant improvement in severity of ARIE, weight loss, head and neck specific symptoms or symptom interference compared with placebo in patients with advanced thoracic malignancies receiving radiotherapy to the esophagus. […] The purpose of this study was to assess the effects of glutamine, a common nutritional supplement, on ARIE in patients with thoracic malignancies. […] There was no grade 3 or higher adverse event at least possibly related to glutamine. […] The study was terminated for futility following interim analysis.
  • #1 Esophagitis in Cats, Signs and Treatments | Academy EN
    https://vetfocus.royalcanin.com/en/scientific/feline-esophagitis
    Feline esophagitis may be subclinical in nature or can often cause nonspecific clinical signs; it is probably underdiagnosed in general practice. […] Treatment is based on drug therapy to inhibit gastric acid secretion and promote gastric emptying. […] Esophagitis must be treated as early as possible, as prolonged inflammation can cause an esophageal stricture secondary to scar tissue formation. Some practitioners opt to use proton pump inhibitors or prokinetic agents prophylactically before any anesthetic procedure in cats to prevent reflux esophagitis. Alternatively, sucralfate suspension may be administered after anesthetic induction to provide protection against any refluxed gastric contents. […] Efforts should always be made to prevent recurrence in any cat that has had esophagitis previously.
  • #1 Esophagitis:Treatment, Symptoms, Causes, Diet & Lifestyle Change
    https://www.emedicinehealth.com/esophagitis/article_em.htm
    What Can I Do to Prevent Esophagitis? […] By following dietary and lifestyle recommendations such as those suggested for GERD, some types of esophagitis can be prevented. […] Discuss symptoms with your physician early and start treatment promptly to prevent more severe inflammation.
  • #1 Barrett’s Esophagus: Symptoms, Causes, Treatments & Medications
    https://my.clevelandclinic.org/health/diseases/14432-barretts-esophagus
    The known causes of chronic esophagitis leading to Barretts esophagus are treatable. Most people have these conditions for a long time before they progress to Barretts esophagus. You can help prevent this from happening by paying attention to your symptoms and seeking treatment for these conditions. You can also reduce your risk by avoiding or quitting smoking. A healthcare provider can help you quit.
  • #1 GERD and Your Throat: Esophageal Damage, Complications, and Prevention
    https://www.healthline.com/health/gerd/and-your-throat
    Frequent acid reflux can damage your esophagus and throat. Treatment may prevent complications. […] Proper treatment for frequent heartburn or GERD can help you avoid these complications. […] Depending on the severity and frequency of your symptoms, doctors may recommend medications to reduce acid production or surgery like fundoplication to improve how your lower esophageal sphincter works to keep acid out of your esophagus. This can help prevent symptoms and future damage. […] Treatment for GERD may prevent symptoms and reduce the risk of these complications.
  • #1 Esophagitis: Symptoms, Causes, Risk Factors & Prevention
    https://www.medicoverhospitals.in/diseases/esophagitis/
    The preventive measures of esophagitis include: Dietary and lifestyle modifications may help avoid esophagitis due to GERD. Good dental hygiene can prevent candida yeast-induced esophagitis. Take all medications upright with lots of water. […] The treatment of esophagitis involves taking medicines and adapting to good lifestyle habits. Precautions and self-care will help to fight this condition positively and improve your quality of life.
  • #2 Esophagitis- Causes, Diagnosis, Treatment and Prevention – Dr AvinashTank, is a super-specialist (MCh) Laparoscopic Gastro-intestinal Surgeon,
    https://dravinashtank.in/gastro_health/esophagitis-causes-diagnosis-treatment-and-prevention/
    Lifestyle changes, dietary modifications, medication management, infection prevention, allergen identification. […] Maintaining a healthy weight, avoiding smoking, and minimizing alcohol consumption can reduce the risk of developing esophagitis. […] Identifying and avoiding trigger foods that worsen symptoms can help prevent recurrent esophagitis. […] If you’re on medications that may irritate the esophagus, discuss alternatives with your healthcare provider. […] Practicing good hygiene to avoid infections that can lead to infectious esophagitis, particularly in those with weakened immune systems. […] For individuals with eosinophilic esophagitis, identifying and managing allergens through an allergist’s guidance is essential.
  • #2 Esophagitis primary prevention – wikidoc
    https://wikidoc.org/index.php/Esophagitis_primary_prevention
    Effective primary preventive measures for esophagitis include weight loss, having head elevated while sleeping, and avoidance of certain foods that can trigger inflammation of esophagus. […] Effective primary preventive measures for esophagitis include: […] Avoidance of following foods: Coffee, Alcohol, Excessive amounts of vitamin C supplements, Foods high in fats, Smoking, Eating shortly before bedtime, Large meals, Chocolate and peppermint, Acidic foods, such as oranges and tomatoes, Cruciferous vegetables such as: onions, cabbage, cauliflower, broccoli, spinach, brussel sprouts, Milk and milk-based products.
  • #2 Esophagitis – StatPearls – NCBI Bookshelf
    https://www.ncbi.nlm.nih.gov/books/NBK442012/
    Patient education is key when a diagnosis of esophagitis is made. The patient should be told to sleep with the head of bed elevated, avoid lying supine after a meal and lose weight. The patient should also avoid caffeinated beverages, alcohol and discontinue smoking. Finally, the patient should be told to avoid NSAIDS.[16][17]
  • #2 Esophagitis: What It Is, Symptoms, Causes & Treatment
    https://my.clevelandclinic.org/health/diseases/10138-esophagitis
    Esophagitis will heal if you can stop whats irritating your esophagus long enough to let the natural healing process continue. This may require various lifestyle changes or medications, depending on the cause. Medications can also help to protect and promote healing in your esophagus. […] Treatment typically includes medication and lifestyle changes. […] Lifestyle recommendations may include: […] Dietary changes. Identify the foods and drinks that trigger acid indigestion and reflux or that trigger an allergic reaction. […] Medication changes. Ask your provider about switching medications that cause esophagitis, or consider switching to a liquid form. If you have to take a pill, take it with a full glass of water. […] Evening routine. To reduce acid reflux, eat smaller meals, especially at dinner time. Make sure dinner is at least three hours before bedtime to give it a chance to digest before you lie down.
  • #2 Esophagitis: Causes, Symptoms, & Treatments
    https://www.webmd.com/digestive-disorders/esophagitis
    To avoid getting esophagitis, or to keep it from coming back, try these tips: […] Avoid foods that are spicy, fatty, hard, or acidic, and keep caffeine, chocolate, and mint-flavored foods to a minimum. […] Try not to eat right before bedtime. […] Take small bites and chew food thoroughly. […] Avoid alcohol and tobacco. […] When you take medication, take it with plenty of water. […] Don’t take medicine lying down or right before you go to sleep. […] Ask your doctor if losing weight would help your symptoms. […] Avoid bending or stooping down right after you eat. […] Raise one end of your bed by 6-8 inches to elevate your head. You can put blocks under your bed or put a wedge between your box springs and mattress. Simply using more pillows won’t work.
  • #2 Esophagitis: What It Is, Symptoms, Causes & Treatment
    https://my.clevelandclinic.org/health/diseases/10138-esophagitis
    Commonsense self-care. Quit smoking and avoid alcohol to protect your esophagus. […] During recovery, take care to: […] Avoid irritants in your esophagus, such as spicy and acidic foods, alcohol and smoking. […] Consider a soft diet to reduce friction in your esophagus while its healing. […] Take small bites of food and chew well before swallowing. […] Stay hydrated with water or soothing teas, such as marshmallow and slippery elm.
  • #2 Esophagitis Guide: Causes, Symptoms and Treatment Options
    https://www.drugs.com/health-guide/esophagitis.html
    The most common cause of esophagitis, acid reflux, sometimes can be prevented by some very simple measures: […] Avoid heavy meals, especially within several hours of bedtime. […] Cut out cigarettes and alcohol. […] Avoid large amounts of caffeine, chocolate, peppermint, and high-fat foods. […] Control your weight. […] If you have heartburn despite these measures, your doctor may suggest you take a preventive acid-blocking medicine. […] All prescription and nonprescription pills should be taken while you are upright and should be swallowed with water. This is especially important for the medicines that frequently cause esophagitis.
  • #2 Esophagitis
    https://healthlibrary.avera.org/Library/Wellness/Prevention/134,170
    Esophagitis can come back. You will need to follow your healthcare providers advice about lifestyle changes and medicine use. […] Your healthcare provider may advise these lifestyle changes if your condition is caused by GERD: Raise the head of your bed. This will help prevent reflux when you sleep. […] Change your eating habits. You may need to switch to a bland diet for a while. This means not having spicy foods, citrus, chocolate, fatty foods, or caffeine. […] Stop smoking. […] Dont drink alcohol or limit how much you drink. […] Keep a healthy weight. […] Be more active.
  • #2 Esophagitis: Types, Symptoms, Causes, Diagnosis, Treatment
    https://www.health.com/esophagitis-overview-7495960
    It is not always possible to prevent esophagitis, but certain preventive measures may lower your risk of developing the condition or prevent recurrences: […] Maintain a healthy weight […] Avoid eating large meals and opt for smaller, more frequent meals […] Avoid lying down immediately after meals […] Identify and avoid trigger foods that worsen acid reflux symptoms (e.g., spicy, acidic, or fried foods, alcohol, caffeine, carbonated beverages) […] Quit smoking […] Take all medications while you are sitting or standing upright, and swallow with plenty of water […] Seek treatment for ongoing episodes of acid reflux (heartburn)
  • #2 Coping Strategies for Esophagitis | Austin Gastroenterology
    https://www.austingastro.com/2021/09/24/coping-strategies-for-esophagitis/
    Esophagitis happens when your esophagus is inflamed. […] You need to control esophagitis early on to prevent it from developing into more severe conditions like Barrett’s esophagus. […] The prevention of acid reflux is one of the strategies for preventing and dealing with esophagitis. […] You should avoid foods that are spicy and acidic. […] Some people also experience esophagitis due to food allergies. […] Sometimes, certain types of drugs can also cause esophagitis. […] Quitting smoking and limiting alcohol intake can help you cope with this condition. […] Poor eating and swallowing habits can also worsen symptoms of esophagitis. […] You can also control your symptoms of esophagitis by eating softer foods. […] Overall, you should consider developing better digestive health habits.
  • #2 Gastroesophageal Reflux Disease (GERD) – Digestive Disorders – Merck Manual Consumer Version
    https://www.merckmanuals.com/home/digestive-disorders/esophageal-and-swallowing-disorders/gastroesophageal-reflux-disease-gerd
    Several measures may be taken to relieve gastroesophageal reflux: […] Raising the head of the bed about 6 inches (about 15 centimeters) by placing 6- to 8-inch (about 15- to 20-centimeter) blocks under the legs at the head of the bed, by using a wedge pillow, or by placing a wedge under the mattress can help prevent acid from flowing into the esophagus as a person sleeps. […] Medications that cause symptoms should be avoided, as should smoking. […] Caffeine, alcohol, fatty foods, chocolate, acid-containing beverages such as orange juice, cola drinks, vinegar-based salad dressings, and other substances that strongly stimulate the stomach to produce acid or that delay stomach emptying should be avoided as well. People should avoid eating 3 hours before bedtime. […] People who are overweight and those who have gained weight recently should lose weight.
  • #2 Esophagitis – StatPearls – NCBI Bookshelf
    https://www.ncbi.nlm.nih.gov/books/NBK442012/
    Lifestyle and dietary modifications are important parts of treatment and further prevention of esophagitis. Patient with Acid reflux esophagitis who are overweight should try for weight loss. Common dietary triggers and habits which include fatty and spicy meals, coffee, carbonated drinks, spicy food, chocolate, alcohol, smoking and not keeping enough time between dinner and bedtime should be avoided. The elevating head end of the bed to 30-45 degree can help with nocturnal symptoms of acid reflux include night cough, sore throat and voice hoarseness. Patient diagnosed with EoE should avoid foods they are allergic to. Maintenance of small meals, clear liquid or soft puree diet during treatment can help with symptoms and accelerate healing time.[15] […] To avoid delay in diagnosis, an interprofessional approach is necessary. The prognosis for most patients is good with prompt treatment, but ultimately the outcomes depend on the underlying cause. When esophagitis is recurrent, it can lead to anxiety and absenteeism from work because of the need to rule out other more serious causes of chest pain.
  • #2 Pill Esophagitis and Medication-Induced Throat Pain
    https://www.verywellhealth.com/medications-that-can-harm-the-esophagus-1943025
    Changing medications may only be part of the solution if you have pill esophagitis. There are certain habits you can adjust to help reduce the risk of future episodes. […] If you are prone to pill esophagitis, the following practical tips may help: Stand or sit upright whenever swallowing pills. Drink a sip or two of water before taking a pill. Drink an entire glass of water after taking a pill. Take your pills one at a time rather than all at once. Eat some food after taking a pill. Wait 30 minutes or longer after taking a pill before lying down.
  • #2 Corrosive Esophagitis – What You Need to Know
    https://www.drugs.com/cg/corrosive-esophagitis.html
    What can I do to prevent corrosive esophagitis? […] Sit or stand when you take your medicine. Do not lie down after you take your pills. Stay in an upright position for 10 to 15 minutes after you take your pills. […] Store harmful chemicals in a safe location. Label bottles with harmful substances. […] Ask for other ways to take your medicine. If you have a narrow esophagus, ask if you can take your medicine in liquid form. Ask if you can crush the pill and mix it with liquid to drink. If you must swallow pills, take them 1 at a time. Take each one with at least 4 ounces of liquid.
  • #2
    https://medcline.com/blogs/acid-reflux/pill-induced-esophagitis?srsltid=AfmBOoqQ2crj12vAZaFQbNYg-BFWiusjETyUNAsJUBEzf8EuEGwHgght
    Pill-Induced Esophagitis Prevention […] Although there are various treatments for drug-induced esophagitis, the best treatment is always prevention. Taking the proper measures to swallow your pills correctly can prevent this situation from happening all together, which is always the best case scenario. Here are a few ways to prevent pill-induced esophagitis: […] Always take your medication with enough water […] Take a pill with at least 200 to 250 ml of water […] Avoid laying down on your stomach after taking a pill […] The prone position makes it more likely that a pill will get stuck in your esophagus […] Take a pill at least 30 minutes before going to bed […] You produce less saliva and swallow less while you sleep, making it more likely that a pill can get stuck […] Eat a meal after taking a pill
  • #2 Esophagitis: Care Instructions | Kaiser Permanente
    https://healthy.kaiserpermanente.org/health-wellness/health-encyclopedia/he.esophagitis-care-instructions.abr9842
    If you have acid reflux, your doctor may recommend that you: […] Take stronger acid reducers. Examples are famotidine (such as Pepcid) and omeprazole (such as Prilosec). Your doctor may also prescribe acid reducers for you. […] If esophagitis is caused by an infection, you may need to take antibiotics or other medicines to treat the infection. […] If you have esophagitis caused by a food allergy, your doctor may prescribe corticosteroids.
  • #2 IDDF2018-ABS-0129 Effectiveness of rebamipide in the prevention of esophageal stricture formation in advanced corrosive esophagitis: a prospective randomised control study | Gut
    https://gut.bmj.com/content/67/Suppl_2/A53.2
    Corrosive esophagitis causes significant morbidity with grades 2b and 3 esophagitis developing strictures in 70%100% of cases. Currently, theres no clear evidence in preventing esophageal stricture. However, animal studies show that suppressing inflammation can prevent stricture formation. Rebamipide, an anti-ulcer agent, has been shown to stimulate prostaglandin generation, increases epidermal growth factor expression, increases blood flow, and scavenges active oxygen radicals thereby reducing inflammation. This study aims to determine the effectiveness of rebamipide in preventing stricture formation in advanced corrosive esophagitis. […] PPI with rebamipide is effective in preventing dysphagia and stricture formation among patients with advanced corrosive esophagitis compared to PPI alone. However, this was not effective in preventing gastric stricture formation.
  • #2 Melatonin in Prevention of the Sequence from Reflux Esophagitis to Barrett’s Esophagus and Esophageal Adenocarcinoma: Experimental and Clinical Perspectives
    https://www.mdpi.com/1422-0067/19/7/2033
    The major function of locally produced melatonin in the GI-tract is to strengthen the esophageal and gastric mucosal barrier and to afford protection against the damage to esophageal and gastric mucosa against the deleterious action of various stressors including mucosal irritants of endogenous or exogenous origin, such as cytotoxins present in the digested food, alcohol consumption and NSAIDs ingestion. […] Melatonin has been shown to afford esophagoprotection against acute esophageal injury from acid and alkaline reflux in animals, but whether melatonin supplementation can protect patients with GERD from esophageal erosions and BE, and from developing neoplasia in humans, requires further clinical trials.
  • #2 Infections of the Esophagus, Stomach, and Duodenum
    https://www.atsu.edu/faculty/chamberlain/website/lectures/lecture/gi3.htm
    Infectious esophagitis usually occurs in immunocompromised persons. […] Many different microorganisms can cause infectious esophagitis; however, the most common infectious cause of esophagitis is Candida albicans. […] Esophagitis is most common in immunocompromised patients. […] Major predisposing factors of esophagitis include antibiotic use, radiation therapy or chemotherapy, hematologic malignancies, and HIV infection. […] Patients should avoid situations that cause immunosuppression or destroy the composition of the normal flora (e.g., broad-spectrum antibiotic therapy).
  • #2 Esophagitis – infectious Information | Mount Sinai – New York
    https://www.mountsinai.org/health-library/diseases-conditions/esophagitis-infectious
    If you have a weak immune system, try to avoid contact with people who have an infection with any of the organisms mentioned above. […] Many people need other long-term medicines to suppress the virus or fungus and to prevent the infection from coming back.
  • #2 Esophagitis: Symptoms, Causes, Risk Factors & Prevention
    https://www.medicoverhospitals.in/diseases/esophagitis/
    The preventive measures of esophagitis include: Dietary and lifestyle modifications may help avoid esophagitis due to GERD. Good dental hygiene can prevent candida yeast-induced esophagitis. Take all medications upright with lots of water. […] The treatment of esophagitis involves taking medicines and adapting to good lifestyle habits. Precautions and self-care will help to fight this condition positively and improve your quality of life.
  • #2 Understanding Esophagitis: A Guide to Relief and Recovery
    https://www.drvikassingla.com/understanding-esophagitis-a-guide-to-relief/
    The best treatment for anything is always prevention. To avoid esophagitis, observe these practices: Management of GERD: Always be able to manage acid reflux through prevention of night time meal consumption, along with ideal body weight maintenance. Take medicines accordingly: Swallow your pills using sufficient water. Never lie down right after medication. Discuss food and environmental allergies: You should find an allergist who can assist you in treating the food or environmental allergies that you have. […] To reduce your risk: Manage acid reflux through diet and weight control. Take medications with plenty of water and avoid lying down immediately after. Address food or environmental allergies with the help of a specialist.
  • #2
    https://link.springer.com/article/10.1007/s10637-021-01074-w
    Oral glutamine was not associated with significant improvement in severity of ARIE, weight loss, head and neck specific symptoms or symptom interference compared with placebo in patients with advanced thoracic malignancies receiving radiotherapy to the esophagus. […] The purpose of this study was to assess the effects of glutamine, a common nutritional supplement, on ARIE in patients with thoracic malignancies. […] There was no grade 3 or higher adverse event at least possibly related to glutamine. […] The study was terminated for futility following interim analysis.
  • #2 Esophagitis in Cats, Signs and Treatments | Academy EN
    https://vetfocus.royalcanin.com/en/scientific/feline-esophagitis
    Clients should be informed that multiple procedures (at least three, but possibly more than ten, times) may be necessary for satisfactory long-term improvement. In terms of prevention, owners should be made aware that a cat with frequent vomiting risks reflux esophagitis, and educated to ensure adequate water intake if administering antibiotics.
  • #2 GERD and Your Throat: Esophageal Damage, Complications, and Prevention
    https://www.healthline.com/health/gerd/and-your-throat
    Frequent acid reflux can damage your esophagus and throat. Treatment may prevent complications. […] Proper treatment for frequent heartburn or GERD can help you avoid these complications. […] Depending on the severity and frequency of your symptoms, doctors may recommend medications to reduce acid production or surgery like fundoplication to improve how your lower esophageal sphincter works to keep acid out of your esophagus. This can help prevent symptoms and future damage. […] Treatment for GERD may prevent symptoms and reduce the risk of these complications.
  • #2 Eosinophilic esophagitis (EoE) – USZ
    https://www.usz.ch/en/disease/eosinophilic-esophagitis/
    Eosinophilic esophagitis cannot be prevented according to current knowledge because the causes and risk factors have not yet been precisely clarified. […] There are also no targeted measures for the early detection of EoE. Always visit us promptly if you suffer from symptoms, especially swallowing disorders or pain behind the breastbone. It can also be caused by other diseases, for example reflux disease. […] Sufficient and long-term treatment can mitigate these consequences or even prevent them altogether.
  • #2 Melatonin in Prevention of the Sequence from Reflux Esophagitis to Barrett’s Esophagus and Esophageal Adenocarcinoma: Experimental and Clinical Perspectives
    https://www.mdpi.com/1422-0067/19/7/2033
    Melatonin, a highly lipophilic hormone, can reach body target cells rapidly, acting as the circadian signal to alter numerous physiological functions in the body. This review focused on the role played by melatonin in the mechanism of esophagoprotection, starting with its short-term protection against acute reflux esophagitis and then investigating the long-term prevention of chronic inflammation that leads to gastroesophageal reflux disease (GERD) and Barrett’s esophagus. […] The beneficial influence of melatonin in preventing esophageal injury from acid-pepsin and acid-pepsin-bile exposure in animals as well as the usefulness of melatonin and its precursor, L-tryptophan in prophylactic and supplementary therapy against esophageal disorders in humans, are also discussed. […] Melatonin acts on the target cells either directly or via G-protein coupled membrane receptors, including melatonin MT1R, MT2R and MT3R known to trigger several intracellular messengers such as cAMP, cGMP, and cytosolic Ca2+ concentration.
  • #2 Esophagitis
    https://healthlibrary.brighamandwomens.org/Library/PreventionGuidelines/134,170
    What can I do to prevent esophagitis? Esophagitis can come back. You will need to follow your healthcare providers advice about lifestyle changes and medicine use. […] Treatment depends on the cause. It will also depend on how severe the condition is. Treatments include: […] Your healthcare provider may advise these lifestyle changes if your condition is caused by GERD: Raise the head of your bed. This will help prevent reflux when you sleep. Change your eating habits. You may need to switch to a bland diet for a while. This means not having spicy foods, citrus, chocolate, fatty foods, or caffeine. Stop smoking. Dont drink alcohol or limit how much you drink. Keep a healthy weight. Be more active. […] Esophagitis can come back. You will need to follow your healthcare providers advice about lifestyle changes and medicine use.