Mięśniaki macicy
Leczenie

Mięśniaki macicy (leiomyoma uteri) to najczęstsze łagodne guzy żeńskiego układu rozrodczego, występujące u 70-80% kobiet do 50. roku życia. Leczenie zależy od objawów, wieku, lokalizacji i wielkości mięśniaków oraz planów prokreacyjnych. W przypadku bezobjawowych lub łagodnych dolegliwości zalecana jest obserwacja (watchful waiting). Farmakoterapia obejmuje NLPZ (np. ibuprofen, kwas mefenamowy stosowane 3x dziennie od początku miesiączki), kwas traneksamowy, doustne środki antykoncepcyjne, progestageny, wkładkę wewnątrzmaciczną z lewonorgestrelem oraz analogi GnRH (np. Lupron, Synarel) stosowane krótkoterminowo (1-3 miesiące) w celu zmniejszenia objętości mięśniaków nawet o 50%. Antagoniści GnRH (np. Elagolix) mogą całkowicie zatrzymać miesiączkowanie do 24 miesięcy, a selektywne modulatory receptora progesteronowego (SPRM, np. octan uliprystalu) redukują objętość mięśniaków o 17-57% i masę macicy o 93-95%, jednak wymagają monitorowania funkcji wątroby.

  1. Leczenie mięśniaków macicy – wprowadzenie
  2. Leczenie zachowawcze mięśniaków macicy
    1. Niesteroidowe leki przeciwzapalne (NLPZ)
    2. Leki antyfibrynolityczne
    3. Hormonalna antykoncepcja
    4. Progestageny
    5. Analogi gonadoliberyny (GnRH)
    6. Antagoniści GnRH
    7. Selektywne modulatory receptora progesteronowego (SPRM)
  3. Leczenie chirurgiczne mięśniaków macicy
    1. Miomektomia
    2. Histerektomia
    3. Ablacja endometrium
  4. Małoinwazyjne metody leczenia mięśniaków macicy
    1. Embolizacja tętnic macicznych (UAE/UFE)
    2. Ablacja przezmięśniakowa o częstotliwości radiowej (RFA)
    3. MR-guided Focused Ultrasound Surgery (MRgFUS)
  5. Kryteria wyboru metody leczenia mięśniaków macicy
    1. Stopień nasilenia objawów
    2. Wiek pacjentki i bliskość menopauzy
    3. Plany prokreacyjne
    4. Wielkość, liczba i lokalizacja mięśniaków
  6. Skuteczność różnych metod leczenia mięśniaków macicy
    1. Leczenie farmakologiczne – skuteczność
    2. Embolizacja tętnic macicznych – skuteczność
    3. Miomektomia – skuteczność
    4. Histerektomia – skuteczność
    5. Ablacja o częstotliwości radiowej – skuteczność
    6. MRgFUS – skuteczność
  7. Powikłania i efekty uboczne leczenia mięśniaków macicy
    1. Leczenie farmakologiczne – powikłania
    2. Embolizacja tętnic macicznych – powikłania
    3. Miomektomia – powikłania
    4. Histerektomia – powikłania
    5. MRgFUS – powikłania
  8. Podejście multidyscyplinarne w leczeniu mięśniaków macicy
    1. Zespół specjalistów
    2. Indywidualizacja leczenia
  9. Perspektywy i nowe kierunki w leczeniu mięśniaków macicy
    1. Nowe leki
    2. Zaawansowane techniki małoinwazyjne
    3. Badania kliniczne
  10. Terapia mięśniaków macicy – podsumowanie
    1. Kolejne rozdziały

Leczenie mięśniaków macicy – wprowadzenie

Mięśniaki macicy (łac. leiomyoma uteri) są najczęstszymi łagodnymi nowotworami żeńskiego układu rozrodczego, występującymi u około 70-80% kobiet do 50. roku życia. Nie wszystkie mięśniaki wymagają leczenia, ponieważ wiele z nich nie powoduje objawów lub wywołuje jedynie łagodne dolegliwości, z którymi pacjentki mogą żyć. Wybór metody leczenia zależy od wielu czynników, takich jak: wiek pacjentki, nasilenie objawów, wielkość i lokalizacja mięśniaków, plany dotyczące zachowania płodności oraz preferencje pacjentki12.

W przypadku bezobjawowych mięśniaków lub powodujących minimalne dolegliwości, lekarze często zalecają postawę wyczekującą (tzw. watchful waiting), polegającą na regularnej obserwacji bez wdrażania aktywnego leczenia. Mięśniaki często zmniejszają się po menopauzie, gdy spada poziom estrogenów. Jeśli jednak objawy są dokuczliwe i wpływają na jakość życia pacjentki, dostępne są różne opcje terapeutyczne – od leczenia farmakologicznego, przez małoinwazyjne zabiegi, aż po interwencje chirurgiczne12.

Leczenie zachowawcze mięśniaków macicy

Leczenie zachowawcze jest zazwyczaj pierwszym krokiem w terapii objawowych mięśniaków macicy, szczególnie u kobiet, które pragną zachować płodność lub zbliżają się do menopauzy. Obejmuje ono różne opcje farmakologiczne, których celem jest kontrola objawów, takich jak obfite krwawienia miesiączkowe czy ból miednicy1.

Niesteroidowe leki przeciwzapalne (NLPZ)

NLPZ, takie jak ibuprofen i kwas mefenamowy, mogą być stosowane 3 razy dziennie od pierwszego dnia miesiączki do momentu ustąpienia lub zmniejszenia krwawienia do akceptowalnego poziomu. Leki te pomagają zmniejszyć ból i skurcze związane z mięśniakami, a także mogą nieco ograniczyć obfitość krwawienia miesiączkowego12.

Leki antyfibrynolityczne

Kwas traneksamowy może być stosowany u pacjentek z obfitymi krwawieniami miesiączkowymi, jeśli inne metody (np. wkładka wewnątrzmaciczna uwalniająca lewonorgestrel) są nieodpowiednie. Jest to lek niehormolalny, który pomaga zmniejszyć krwawienie poprzez hamowanie rozpadu skrzepów krwi12.

Hormonalna antykoncepcja

Doustne środki antykoncepcyjne oraz inne metody hormonalnej antykoncepcji (plastry, pierścienie dopochwowe) mogą pomóc w kontroli obfitych krwawień miesiączkowych związanych z mięśniakami. Estrogen zawarty w tych preparatach pomaga skrócić miesiączki i zmniejszyć krwawienie. Nie powodują one jednak zmniejszenia mięśniaków i mogą nie być skuteczne w przypadku dużych zmian12.

Progestageny

Leki zawierające syntetyczny progesteron (progestageny) mogą być stosowane doustnie lub jako iniekcje w celu zmniejszenia obfitych krwawień miesiączkowych. Skuteczną metodą jest także wkładka wewnątrzmaciczna uwalniająca lewonorgestrel (LNG-IUS), która może znacząco zmniejszyć krwawienie miesiączkowe u kobiet z mięśniakami, choć nie jest zalecana u pacjentek z dużymi mięśniakami zniekształcającymi jamę macicy12.

Analogi gonadoliberyny (GnRH)

Analogi GnRH (np. Lupron, Synarel, Zoladex) powodują stan podobny do menopauzy poprzez blokowanie produkcji estrogenów i progesteronu. Prowadzi to do zmniejszenia wielkości mięśniaków i macicy – objętość macicy może zmniejszyć się o około 50% po trzech miesiącach terapii1.

Niestety, długotrwałe stosowanie analogów GnRH może prowadzić do utraty masy kostnej i innych objawów przypominających menopauzę. Po zakończeniu leczenia obserwuje się szybki nawrót mięśniaków do pierwotnej wielkości. Z tego powodu analogi GnRH są zwykle stosowane krótkoterminowo (1-3 miesiące) przed zabiegiem operacyjnym w celu zmniejszenia mięśniaków lub poprawy stanu anemii przed operacją12.

Antagoniści GnRH

W przeciwieństwie do agonistów GnRH, antagoniści GnRH szybko blokują receptory GnRH, powodując zmniejszenie wydzielania estradiolu i progesteronu bez początkowego efektu wzmożonego uwalniania hormonów. Leki te, takie jak Elagolix (Oriahnn), mogą zmniejszyć obfite krwawienie i nawet całkowicie zatrzymać miesiączkowanie podczas stosowania (do 24 miesięcy)12.

Selektywne modulatory receptora progesteronowego (SPRM)

SPRM, takie jak octan uliprystalu, wykazują zdolność do zmniejszania objętości mięśniaków o 17-57% i redukcji masy macicy o 95-93%. Działają one poprzez selektywne wiązanie z receptorem progesteronowym, wpływając na wzrost mięśniaków12.

Liczne badania kliniczne potwierdziły skuteczność i bezpieczeństwo octanu uliprystalu w leczeniu objawowych mięśniaków macicy, chociaż należy monitorować funkcję wątroby podczas stosowania tego leku1.

Leczenie chirurgiczne mięśniaków macicy

Gdy leczenie zachowawcze nie przynosi satysfakcjonujących efektów lub gdy mięśniaki są bardzo duże i powodują znaczne objawy, można rozważyć leczenie chirurgiczne. Wybór metody zależy od wieku pacjentki, jej planów prokreacyjnych oraz lokalizacji i wielkości mięśniaków1.

Miomektomia

Miomektomia to zabieg chirurgiczny polegający na usunięciu mięśniaków z zachowaniem macicy. Jest to preferowana opcja dla kobiet, które pragną zachować płodność. W zależności od lokalizacji i wielkości mięśniaków, zabieg może być wykonywany różnymi technikami12:

  • Miomektomia histeroskopowa – stosowana w przypadku mięśniaków podśluzówkowych; nie wymaga nacięcia brzucha, gdyż narzędzia wprowadzane są przez pochwę i szyjkę macicy.
  • Miomektomia laparoskopowa – wykonywana przez kilka małych nacięć w brzuchu, z wykorzystaniem kamery i specjalistycznych narzędzi; może być wspomagana robotem (np. system da Vinci).
  • Miomektomia brzuszna (laparotomiczna) – tradycyjna operacja poprzez większe nacięcie brzucha, stosowana przy dużych lub licznych mięśniakach.

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Miomektomia poprawia objawy w około 80% przypadków, ale wiąże się z ryzykiem nawrotu mięśniaków – około 27% w przypadku usunięcia jednego mięśniaka i ponad 50% przy mnogich mięśniakach1.

Histerektomia

Histerektomia (usunięcie macicy) jest jedyną metodą, która całkowicie i trwale eliminuje problem mięśniaków. Zabieg ten jest rozważany u kobiet, które nie planują już ciąży i cierpią z powodu ciężkich, nawracających objawów mięśniaków, które nie reagują na inne metody leczenia12.

Histerektomia może być wykonywana różnymi technikami1:

  • Histerektomia pochwowa – macica usuwana jest przez pochwę, bez nacięć brzucha.
  • Histerektomia laparoskopowa – wykonywana przez małe nacięcia w brzuchu, z użyciem kamery i specjalistycznych narzędzi; może być wspomagana robotem.
  • Histerektomia brzuszna – wykonywana przez większe nacięcie brzucha, stosowana przy dużych mięśniakach lub gdy istnieją inne komplikacje.

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Warto podkreślić, że podczas histerektomii z powodu mięśniaków zazwyczaj nie ma potrzeby usuwania jajników, co pozwala uniknąć przedwczesnej menopauzy i konieczności stosowania hormonalnej terapii zastępczej1.

Ablacja endometrium

Ablacja endometrium to procedura, która polega na zniszczeniu błony śluzowej macicy (endometrium) w celu zmniejszenia lub zatrzymania krwawień miesiączkowych. Jest stosowana głównie u pacjentek z małymi (poniżej 1 cm średnicy) mięśniakami podśluzówkowymi, które powodują obfite krwawienia12.

Zabieg może być wykonywany przy użyciu różnych technik, takich jak ablacja termiczna, laserowa czy kriochirurgia. Jest to procedura małoinwazyjna, zwykle wykonywana ambulatoryjnie, ale nie jest zalecana kobietom planującym ciążę, ponieważ może zwiększyć ryzyko powikłań ciążowych1.

Małoinwazyjne metody leczenia mięśniaków macicy

Oprócz tradycyjnych metod chirurgicznych, dostępnych jest kilka małoinwazyjnych technik leczenia mięśniaków macicy, które oferują krótszy czas rekonwalescencji i mniejsze ryzyko powikłań1.

Embolizacja tętnic macicznych (UAE/UFE)

Embolizacja tętnic macicznych (UAE – Uterine Artery Embolization lub UFE – Uterine Fibroid Embolization) to małoinwazyjna procedura radiologiczna polegająca na zamknięciu dopływu krwi do mięśniaków, co prowadzi do ich obkurczenia i obumarcia12.

Podczas zabiegu radiolog interwencyjny wprowadza cewnik przez małe nacięcie w pachwinie lub nadgarstku do tętnicy udowej lub promieniowej, a następnie kieruje go do tętnic macicznych. Przez cewnik wstrzykiwane są drobne cząsteczki, które blokują naczynia krwionośne zaopatrujące mięśniaki. Procedura wykonywana jest w znieczuleniu miejscowym z sedacją, zwykle jako zabieg jednodniowy1.

UAE prowadzi do zmniejszenia objętości mięśniaków o 30-50% i znaczącej poprawy objawów u około 85-90% pacjentek. Efekty zabiegu są zazwyczaj długotrwałe, a pacjentki mogą wrócić do normalnej aktywności w ciągu kilku dni12.

Chociaż UAE pozwala zachować macicę, jej wpływ na przyszłą płodność nie jest w pełni poznany. U niektórych kobiet mogą wystąpić powikłania, takie jak amenorrhea (brak miesiączki) czy problemy z zajściem w ciążę1.

Ablacja przezmięśniakowa o częstotliwości radiowej (RFA)

Ablacja przezmięśniakowa o częstotliwości radiowej (Radiofrequency Ablation – RFA) to małoinwazyjna procedura, która wykorzystuje energię fal radiowych do zniszczenia tkanki mięśniaków. Zabieg może być wykonywany laparoskopowo (Acessa) lub przez szyjkę macicy (Sonata)12.

Podczas zabiegu chirurg lokalizuje mięśniaki za pomocą ultrasonografii, a następnie wprowadza sondę, która emituje energię o częstotliwości radiowej bezpośrednio do mięśniaka. Energia ta powoduje podgrzanie i zniszczenie tkanki mięśniaka, co prowadzi do jego skurczenia się w czasie1.

RFA jest bezpieczną i skuteczną metodą leczenia, która pozwala zachować macicę i umożliwia szybki powrót do codziennych aktywności (zwykle w ciągu kilku dni). Po roku od zabiegu wielkość mięśniaka może zmniejszyć się nawet o 66%, co prowadzi do znacznej redukcji bólu miednicy, obfitych krwawień i uczucia ciężkości1.

MR-guided Focused Ultrasound Surgery (MRgFUS)

Chirurgia ultradźwiękowa kierowana rezonansem magnetycznym (MRgFUS) to nieinwazyjna metoda leczenia mięśniaków, która łączy ultradźwięki o wysokiej intensywności z obrazowaniem metodą rezonansu magnetycznego12.

Podczas zabiegu pacjentka znajduje się w urządzeniu MRI, które dostarcza szczegółowych obrazów mięśniaków i otaczających tkanek. Jednocześnie skoncentrowane wiązki ultradźwięków o wysokiej energii są kierowane na mięśniaki, powodując ich podgrzanie i zniszczenie. Ciągłe monitorowanie temperatury za pomocą MRI pozwala na precyzyjne leczenie bez uszkodzenia otaczających zdrowych tkanek1.

Pojedyncza sesja trwa około 3 godzin. Metoda ta jest nieinwazyjna, nie wymaga nacięć i pozwala na szybki powrót do normalnej aktywności (zazwyczaj następnego dnia). Mięśniaki są leczone i zmniejszają swoją wielkość, ale nie są usuwane1.

Długoterminowa skuteczność MRgFUS nie jest jeszcze w pełni znana, a metoda ta nie jest zalecana kobietom, które chcą zachować płodność1. Jednakże niektóre badania sugerują, że możliwe jest zajście w ciążę i donoszenie jej po zabiegu MRgFUS2.

Kryteria wyboru metody leczenia mięśniaków macicy

Wybór odpowiedniej metody leczenia mięśniaków macicy powinien być zindywidualizowany i uwzględniać wiele czynników1:

Stopień nasilenia objawów

Nasilenie objawów i ich wpływ na jakość życia pacjentki są kluczowymi czynnikami przy podejmowaniu decyzji o leczeniu. Jeśli objawy są łagodne, można rozważyć postawę wyczekującą lub leczenie farmakologiczne. Natomiast ciężkie objawy, takie jak obfite krwawienia prowadzące do anemii, silny ból miednicy czy ucisk na okoliczne narządy, mogą wymagać bardziej inwazyjnych metod leczenia1.

Wiek pacjentki i bliskość menopauzy

U kobiet zbliżających się do menopauzy mięśniaki często ulegają samoistnej redukcji wskutek zmniejszenia poziomu estrogenów. W takich przypadkach można rozważyć krótkoterminowe leczenie objawowe do czasu naturalnego ustąpienia mięśniaków1.

Plany prokreacyjne

Dla kobiet, które planują ciążę, najlepszym wyborem chirurgicznym jest zwykle miomektomia, która pozwala na usunięcie mięśniaków z zachowaniem macicy. Niektóre małoinwazyjne metody, takie jak UAE czy ablacja endometrium, mogą negatywnie wpływać na płodność i nie są zalecane tym pacjentkom12.

Wielkość, liczba i lokalizacja mięśniaków

Mięśniaki podśluzówkowe (rosnące do jamy macicy) mogą być skutecznie leczone za pomocą histeroskopowej miomektomii, podczas gdy duże mięśniaki śródścienne (w ścianie macicy) lub podsurowicówkowe (na zewnętrznej powierzchni macicy) mogą wymagać laparoskopowej lub otwartej miomektomii albo embolizacji tętnic macicznych1.

Metoda leczenia Zalety Wady Zachowanie płodności
Leczenie farmakologiczne Nieinwazyjne, łatwe do stosowania, możliwość kontroli objawów Zazwyczaj tymczasowe efekty, możliwe działania niepożądane Tak
Miomektomia Zachowanie macicy, usunięcie mięśniaków, poprawa objawów Ryzyko nawrotu (do 50%), powikłania operacyjne Tak
Histerektomia Definitywne rozwiązanie, brak ryzyka nawrotu Trwała utrata płodności, powikłania operacyjne Nie
Embolizacja tętnic macicznych (UAE) Małoinwazyjna, zachowanie macicy, szybka rekonwalescencja Niepewny wpływ na płodność, możliwe powikłania Niepewne
Ablacja o częstotliwości radiowej (RFA) Małoinwazyjna, zachowanie macicy, szybki powrót do aktywności Ograniczone dane dotyczące płodności Niepewne
MRgFUS Nieinwazyjna, zachowanie macicy, brak nacięć Ograniczone dane dotyczące długoterminowej skuteczności Niepewne

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Skuteczność różnych metod leczenia mięśniaków macicy

Skuteczność leczenia mięśniaków macicy różni się w zależności od zastosowanej metody1:

Leczenie farmakologiczne – skuteczność

Leki hormonalne (antykoncepcja hormonalna, progestageny) mogą skutecznie kontrolować objawy, takie jak obfite krwawienia miesiączkowe, ale nie zmniejszają znacząco wielkości mięśniaków. Analogi GnRH i selektywne modulatory receptora progesteronowego mogą zmniejszyć wielkość mięśniaków o 17-57%, ale efekt ten jest zwykle tymczasowy i mięśniaki odrastają po zakończeniu leczenia12.

Embolizacja tętnic macicznych – skuteczność

UAE jest wysoce skuteczna – około 85-90% pacjentek doświadcza znaczącej poprawy objawów, takich jak obfite krwawienia, anemia i ból miednicy. Wielkość mięśniaków zmniejsza się zazwyczaj o 30-50%. Niektóre pacjentki zauważają poprawę już w ciągu kilku dni od zabiegu12.

Miomektomia – skuteczność

Miomektomia skutecznie usuwa mięśniaki i łagodzi objawy u około 80% pacjentek. Jednak istnieje ryzyko nawrotu – około 27% w przypadku usunięcia jednego mięśniaka i ponad 50% przy mnogich mięśniakach. Między 10% a 25% pacjentek po miomektomii będzie wymagać ponownej operacji mięśniaków w ciągu okresu reprodukcyjnego12.

Histerektomia – skuteczność

Histerektomia jest jedyną metodą, która całkowicie i trwale eliminuje problem mięśniaków. Zapewnia 100% skuteczność w zapobieganiu nawrotom. Często prowadzi do znaczącej poprawy jakości życia u kobiet z ciężkimi objawami mięśniaków, które nie planują już ciąży1.

Ablacja o częstotliwości radiowej – skuteczność

RFA może zmniejszyć objętość mięśniaków o około 66% po roku od zabiegu, co prowadzi do znaczącej redukcji bólu miednicy, obfitych krwawień i uczucia ciężkości. Procedura ta jest szczególnie skuteczna u pacjentek z kilkoma mięśniakami o wielkości do 5 cm, które powodują objawowe krwawienia12.

MRgFUS – skuteczność

MRgFUS może zapewnić szybką poprawę objawów związanych z mięśniakami bez konieczności inwazyjnej operacji. Skuteczność tej metody w długim okresie nie jest jeszcze w pełni poznana, ale wiele pacjentek doświadcza znaczącej poprawy objawów i jakości życia1.

Powikłania i efekty uboczne leczenia mięśniaków macicy

Każda metoda leczenia mięśniaków macicy wiąże się z potencjalnymi powikłaniami i efektami ubocznymi1:

Leczenie farmakologiczne – powikłania

Analogi GnRH mogą powodować objawy przypominające menopauzę, takie jak uderzenia gorąca, suchość pochwy, zmniejszenie libido, oraz długotrwałą utratę masy kostnej przy dłuższym stosowaniu. Selektywne modulatory receptora progesteronowego mogą wywoływać bóle głowy, tkliwość piersi i w rzadkich przypadkach zmiany w endometrium1.

Embolizacja tętnic macicznych – powikłania

Po UAE najczęstszym powikłaniem jest zespół poembolizacyjny, objawiający się bólem, gorączką i nudnościami, który zazwyczaj ustępuje w ciągu kilku dni. Rzadszymi powikłaniami są infekcje, amenorrhea (brak miesiączki), przedwczesna menopauza (szczególnie u kobiet powyżej 45 roku życia) oraz potencjalne powikłania ciążowe1.

Miomektomia – powikłania

Powikłania miomektomii obejmują duże krwawienie śródoperacyjne, rozwój zrostów (tkanki bliznowatej) w mięśniu macicy i innych miejscach jamy brzusznej, oraz ryzyko pęknięcia macicy podczas porodu (zwłaszcza po miomektomii laparotomicznej)1.

Histerektomia – powikłania

Histerektomia jako poważna operacja wiąże się z ryzykiem powikłań, takich jak krwawienie, infekcje, uszkodzenie okolicznych narządów (pęcherza moczowego, moczowodów, jelit) oraz powikłania związane ze znieczuleniem. Długoterminowe konsekwencje obejmują trwałą utratę płodności i potencjalne problemy psychologiczne związane z utratą narządu1.

MRgFUS – powikłania

MRgFUS ma niskie ryzyko powikłań. Najczęstszymi efektami ubocznymi są przejściowy ból, niewielkie oparzenia skóry i obrzęk tkanek. Procedura ta może nie być dobrym wyborem dla niektórych pacjentek, w tym kobiet w ciąży, pacjentek z licznymi bliznami na brzuchu oraz pacjentek z licznymi lub bardzo dużymi mięśniakami1.

Podejście multidyscyplinarne w leczeniu mięśniaków macicy

Optymalne leczenie mięśniaków macicy często wymaga współpracy specjalistów z różnych dziedzin medycyny1:

Zespół specjalistów

W skład multidyscyplinarnego zespołu do leczenia mięśniaków macicy mogą wchodzić1:

  • Ginekolodzy – przeprowadzają diagnostykę, leczenie farmakologiczne i zabiegi operacyjne, takie jak miomektomia czy histerektomia.
  • Radiolodzy interwencyjni – wykonują zabiegi embolizacji tętnic macicznych (UAE) oraz badania obrazowe.
  • Lekarze medycyny rozrodu – pomagają pacjentkom z mięśniakami, które mają problemy z płodnością.
  • Anestezjolodzy – zapewniają bezpieczne znieczulenie podczas zabiegów.

12

Indywidualizacja leczenia

Podejście multidyscyplinarne pozwala na lepszą indywidualizację leczenia, uwzględniającą wszystkie aspekty zdrowia pacjentki, jej preferencje i cele życiowe. Współpraca specjalistów umożliwia wypracowanie optymalnego planu terapeutycznego, który może łączyć różne metody leczenia dla osiągnięcia najlepszych rezultatów1.

W wielu ośrodkach funkcjonują specjalne zespoły lub kliniki dedykowane leczeniu mięśniaków macicy, gdzie pacjentki mogą uzyskać kompleksową opiekę i dostęp do różnych opcji terapeutycznych pod jednym dachem12.

Perspektywy i nowe kierunki w leczeniu mięśniaków macicy

Badania nad nowymi metodami leczenia mięśniaków macicy są nieustannie prowadzone, a naukowcy poszukują coraz skuteczniejszych i mniej inwazyjnych rozwiązań1:

Nowe leki

Trwają prace nad nowymi lekami, które mogłyby skutecznie leczyć mięśniaki macicy bez poważnych efektów ubocznych. Jednym z obiecujących kierunków są nowe selektywne modulatory receptora progesteronowego oraz antagoniści GnRH z dodatkiem hormonów (add-back therapy) w celu zminimalizowania efektów ubocznych1.

Zaawansowane techniki małoinwazyjne

Rozwijane są także nowe, zaawansowane techniki małoinwazyjne, takie jak przezszyjkowa ablacja o częstotliwości radiowej (Sonata) czy systemy oparte na ultradźwiękach, które mogłyby oferować jeszcze lepsze wyniki przy minimalnym ryzyku powikłań1.

Badania kliniczne

Trwają liczne badania kliniczne oceniające skuteczność i bezpieczeństwo nowych metod leczenia mięśniaków macicy. Jednym z obiecujących kierunków jest zastosowanie kolagenazy (enzymu trawiącego kolagen) w połączeniu z nowatorskimi systemami dostarczania leków, które mogłyby rozłożyć mięśniaki bez konieczności operacji1.

Zespół naukowców z Duke University i North Carolina Central University (NCCU) pracuje nad nowym lekiem zawierającym kolagenazę, który mógłby rozkładać mięśniaki wewnątrz organizmu. Ponieważ mięśniaki są zbudowane głównie z kolagenu, zastosowanie tego enzymu mogłoby stanowić skuteczne rozwiązanie problemu1.

Terapia mięśniaków macicy – podsumowanie

Leczenie mięśniaków macicy powinno być zindywidualizowane i uwzględniać wiele czynników, takich jak nasilenie objawów, wiek pacjentki, plany prokreacyjne oraz wielkość i lokalizacja mięśniaków. Dostępne opcje terapeutyczne obejmują postawę wyczekującą, leczenie farmakologiczne, małoinwazyjne procedury oraz zabiegi chirurgiczne1.

Pacjentka powinna otrzymać pełne informacje o wszystkich dostępnych metodach leczenia, ich skuteczności, potencjalnych korzyściach i ryzyku, aby mogła podjąć świadomą decyzję wspólnie z lekarzem. Optymalne leczenie często wymaga podejścia multidyscyplinarnego, z udziałem specjalistów z różnych dziedzin medycyny12.

Chociaż nie ma jednej „najlepszej” metody leczenia mięśniaków macicy, postęp w badaniach i rozwój nowych technologii stale poszerzają spektrum dostępnych opcji terapeutycznych, oferując pacjentkom coraz skuteczniejsze i mniej inwazyjne rozwiązania. Najważniejsze jest dostosowanie leczenia do indywidualnych potrzeb i preferencji każdej pacjentki12.

Kolejne rozdziały

Zapraszamy do dalszego czytania naszego leksykonu.

Wybierz kolejny rozdział z menu poniżej, aby otworzyć nową podstronę kompedium wiedzy i uzyskać szczegółowe informację o leku, substancji lub chorobie.

  1. 09.04.2026
  2. www.leksykon.com.pl

Materiały źródłowe

  • #1 Uterine Fibroids: Causes, Symptoms & Treatment
    https://my.clevelandclinic.org/health/diseases/9130-uterine-fibroids
    Uterine fibroids can cause a variety of symptoms like pain and heavy, irregular vaginal bleeding. Treatment for fibroids typically depends on your symptoms. […] Treatment for uterine fibroids can vary depending on the size, number and location of the fibroids, as well as what symptoms they’re causing. If you aren’t experiencing any symptoms from your fibroids, you may not need treatment. […] If you’re experiencing symptoms from your fibroids including anemia from excess bleeding, moderate to severe pain or urinary tract and bowel problems you’ll need treatment to help. Your treatment plan will depend on a few factors, including: […] Treatment options for uterine fibroids can include: […] Medications can have side effects and some may not be a good fit for you. […] There are several factors to consider when talking about the different types of surgery for fibroid removal.
  • #1 Uterine Fibroids: Diagnosis and Treatment | AAFP
    https://www.aafp.org/pubs/afp/issues/2017/0115/p100.html
    Uterine fibroids are common benign neoplasms, with a higher prevalence in older women and in those of African descent. […] Expectant management is recommended for asymptomatic patients because most fibroids decrease in size during menopause. Management should be tailored to the size and location of fibroids; the patient’s age, symptoms, desire to maintain fertility, and access to treatment; and the experience of the physician. Medical therapy to reduce heavy menstrual bleeding includes hormonal contraceptives, tranexamic acid, and nonsteroidal anti-inflammatory drugs. […] Surgical treatment includes hysterectomy, myomectomy, uterine artery embolization, and magnetic resonance-guided focused ultrasound surgery. […] Treatment of uterine fibroids should be tailored to the size and location of the tumors; the patient’s age, symptoms, desire to maintain fertility, and access to treatment; and the physician’s experience.
  • #1 Currently Available Treatment Modalities for Uterine Fibroids
    https://pmc.ncbi.nlm.nih.gov/articles/PMC11205795/
    Treatment of fibroids must be individualized based on the presence and severity of symptoms and the patients desire for definitive treatment or fertility preservation. […] Treatment options for uterine fibroids include medicamentous, interventional radiology and surgical options. Generally, it is suggested that the treatment of fibroids begins with medicamentous and minimally invasive treatments before surgery. […] The medicamentous management of fibroids is typically reserved for patients with heavy menstrual bleeding and/or pelvic pain who wish to preserve their fertility. […] Medicamentous therapy yields effective results, and symptoms usually improve after one year of treatment. […] The levonorgestrel-releasing intrauterine system is a contraceptive method that is also ideal for the treatment of heavy menstrual bleeding in patients who have contraindications for COCs.
  • #1
    https://www.nhs.uk/conditions/fibroids/treatment/
    Treatment may not be necessary if you have fibroids but do not have any symptoms, or if you only have minor symptoms that are not significantly affecting your everyday activities. […] If you have fibroids that need treatment, a GP may recommend medicine to help relieve your symptoms. […] But you may need to see a gynaecologist (a specialist in the female reproductive system) for further medicine or surgery if these are ineffective. […] Medicines are available that can be used to reduce heavy periods, but they can be less effective the larger your fibroids are. […] If LNG-IUS is unsuitable (for example, if contraception is not desired) tranexamic acid tablets may be considered. […] Non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen and mefenamic acid, can be taken 3 times a day from the first day of your period until bleeding stops or reduces to manageable levels.
  • #1 Get Uterine Fibroid Treatment | Cleveland Clinic
    https://my.clevelandclinic.org/services/uterine-fibroids-treatment
    Uterine Fibroids Treatment […] You have a range of options when it comes to uterine fibroid treatment. Before creating a treatment plan, we take the time to listen to your needs. We review your symptoms and discuss your goals for fertility preservation. […] […] We offer a wide range of medications to reduce pelvic pain, relieve heavy bleeding during periods and prevent anemia (a lack of iron in the blood). We may recommend: […] Birth control pills: Estrogen helps shorten periods and reduce heavy bleeding. […] Progestin-releasing intrauterine device (IUD): This hormone can reduce blood flow during periods, though an IUD may not be recommended for women with bulk fibroids. […] Tranexamic acid (Lysteda): We give this nonhormonal medication during your period to reduce blood loss. We may recommend it for women who cant have hormonal therapy.
  • #1
    https://www.nhs.uk/conditions/fibroids/treatment/
    The contraceptive pill is a popular method of contraception that stops an egg being released from the ovaries to prevent pregnancy. […] Oral progestogen is synthetic (man-made) progesterone (one of the female sex hormones) that can help reduce heavy periods. […] Progestogen is also available as an injection to treat heavy periods. […] If you’re still experiencing symptoms related to fibroids despite treatment with the above medicines, a GP can refer you to a gynaecologist. […] They may prescribe medicine called gonadotropin releasing hormone analogues (GnRHas) to help shrink your fibroids. […] GnRHas stop your menstrual cycle (period), but are not a form of contraception. […] Surgery to remove your fibroids may be considered if your symptoms are particularly severe and medicine has been ineffective.
  • #1 Fibroid Treatment Options – Brigham and Women’s Hospital
    https://www.brighamandwomens.org/obgyn/infertility-reproductive-surgery/cysts-and-fibroids/non-surgical-fibroid-treatment
    Medicines can help control fibroid-related symptoms. The most effective medications for the treatment of fibroids are gonadotropin releasing hormone agonists (GnRHa), (including Lupron, Synarel, Zoladex). GnRH agonists cause a low-estrogen (menopause-like) state which causes reduction size of the tumor and uterus. Uterine size has been shown to decrease approximately 50 percent after three months of therapy with these medications. […] Unfortunately, long term use of GnRH agonists can lead to bone loss, however when GnRH agonist treatment is stopped it is followed by a rapid regrowth of the fibroids and of the uterus to pre-treatment volume. Therefore the use of GnRH agonists alone for treatment of fibroids is usually limited to a short one to three month preoperative course to shrink the uterus in preparation for surgery or to improve anemia before surgery.
  • #1 Get Uterine Fibroid Treatment | Cleveland Clinic
    https://my.clevelandclinic.org/services/uterine-fibroids-treatment
    Elagolix (Oriahnn): This pill lowers estrogen levels in the body. It reduces heavy bleeding and may stop your periods completely while used, up to 24 months. […] Leuprolide acetate (Lupron Depot): This medication is administered as a shot and lowers estrogen levels in the body. It reduces heavy bleeding and may stop your periods completely. […] Relugolix, Estradiol, Norethindrone acetate (Myfembree): This pill contains a combination of medications that can help decrease heavy bleeding due to fibroids and minimize side effects. […] […] Sometimes fibroid surgery is necessary. Well choose a procedure that fits your fertility goals and personal preferences. Be sure to let us know whats important to you. We offer bloodless surgery for women who dont want a blood transfusion or blood products during surgery.
  • #1 Currently Available Treatment Modalities for Uterine Fibroids
    https://pmc.ncbi.nlm.nih.gov/articles/PMC11205795/
    Selective Progesterone Receptor Modulators (SPRM) have been shown to diminish uterine fibroid volume by 17-57% and to reduce uterine mass by 95-93%. […] Myomectomy is a surgical treatment in which the fibroids are removed and the uterus is then reconstructed. […] Myomectomy improves symptoms in up to 80% of cases but is associated with about a 27% risk of recurrence if one fibroid is removed and a risk level greater than 50% in the case of multiple fibroids. […] A hysterectomy is the last treatment option for symptomatic fibroids. A hysterectomy is a definitive surgical treatment option that eliminates the risk of future recurrence. […] Symptomatic uterine fibroids require surgical and/or medical therapy according to the FIGO classification, severity of symptoms, patients age, infertility and wish to preserve fertility. Currently, the usual treatment for fibroids is surgical intervention, such as hysterectomy and/or fertility-sparing myomectomy performed via hysteroscopy, laparoscopy or laparotomy.
  • #1 Current medical treatment of uterine fibroids
    https://pmc.ncbi.nlm.nih.gov/articles/PMC5854898/
    SPRMs have tissue-specific effects at PRs, and they can have either a complete PR agonist or antagonist profile or a mixed agonist/antagonist profile. […] Many clinical studies have evaluated the efficacy of UPA in the treatment of symptomatic uterine fibroids; however, the most widely cited studies investigating UPA include the European phase III studies, PGL4001 Efficacy Assessment in Reduction of Symptoms Due to Uterine Leiomyomata (PEARL), which demonstrate UPA’s safety and efficacy. […] Uterine fibroids are highly prevalent in reproductive-aged women, and as women continue to delay childbearing, an increasing number of patients will require fertility-preserving treatment options. Medical management of uterine fibroids may provide symptomatic relief of the uterine fibroid-related symptoms along with the opportunity to maintain fertility.
  • #1 Uterine Fibroids: Diagnosis and Treatment | AAFP
    https://www.aafp.org/pubs/afp/issues/2017/0115/p100.html
    The ideal treatment satisfies four goals: relief of signs and symptoms, sustained reduction of the size of fibroids, maintenance of fertility (if desired), and avoidance of harm. […] Hysterectomy provides a definitive cure for women with symptomatic fibroids who do not wish to preserve fertility, resulting in complete resolution of symptoms and improved quality of life. […] Hysteroscopic myomectomy is the preferred surgical procedure for women with submucosal fibroids who wish to preserve their uterus or fertility. […] Uterine artery embolization is an option for women who wish to preserve their uterus or avoid surgery because of medical comorbidities or personal preference. […] Myolysis is a minimally invasive procedure targeting the destruction of fibroids via a focused energy delivery system such as heat, laser, or more recently, magnetic resonance-guided focused ultrasound surgery.
  • #1 Uterine fibroids
    https://womenshealth.gov/a-z-topics/uterine-fibroids
    Most women with fibroids do not have any symptoms. For women who do have symptoms, there are treatments that can help. Talk with your doctor about the best way to treat your fibroids. She or he will consider many things before helping you choose a treatment. Some of these things include: […] If you have fibroids with moderate or severe symptoms, surgery may be the best way to treat them. Here are the options: […] Surgery to remove fibroids without taking out the healthy tissue of the uterus. It is best for women who wish to have children after treatment for their fibroids or who wish to keep their uterus for other reasons. […] Surgery to remove the uterus. This surgery is the only sure way to cure uterine fibroids. […] The lining of the uterus is removed or destroyed to control very heavy bleeding.
  • #1 Uterine fibroids – Diagnosis and treatment – Mayo Clinic
    https://www.mayoclinic.org/diseases-conditions/uterine-fibroids/diagnosis-treatment/drc-20354294
    In a myomectomy, your surgeon removes the fibroids and leaves the uterus in place. […] This surgery removes the uterus. It remains the only proven permanent solution for uterine fibroids. […] With any procedure that doesn’t remove the uterus, there’s a risk that new fibroids could grow and cause symptoms. […] If fibroid treatment is needed and you want to preserve your fertility myomectomy is often the treatment of choice. But all treatments have risks and benefits. Talk about these with your doctor.
  • #1 Get Uterine Fibroid Treatment | Cleveland Clinic
    https://my.clevelandclinic.org/services/uterine-fibroids-treatment
    Less blood loss. […] Quicker recovery. […] Reduced pain after surgery. […] Smaller incision. […] Laparoscopic hysterectomy: By the age of 60, one in three women will have had a hysterectomy (a surgery to remove the uterus). The majority of hysterectomies are done to treat fibroids. […] Many women assume theyll need an open hysterectomy (laparotomy), which would involve a large incision and an extensive recovery. However, we can almost always perform a vaginal or laparoscopic hysterectomy, which only requires small incisions in the abdomen. […] Its important to note that we typically dont remove the ovaries during a hysterectomy if you are premenopausal. This means you wont go into early menopause or need hormone therapy after the procedure. Most women can go home the same day as their surgery. The typical recovery period is two to four weeks.
  • #1 Management of Uterine Fibroids | AAFP
    https://www.aafp.org/pubs/afp/issues/2019/0301/p330.html
    There was moderate strength of evidence that mifepristone, ulipristal, and UAE improve quality of life, and there was low strength of evidence that GnRH agonists, myomectomy, and hysterectomy improve quality of life. […] There are four main goals in the treatment of uterine fibroids: improving symptoms, reducing fibroid size and sustaining the decreased size, preserving fertility if desired, and avoiding harm. […] The 2008 American College of Obstetricians and Gynecologists guidelines address alternatives to hysterectomy for fibroids and emphasize individualizing treatment based on patient goals. […] Adverse effects of nonsurgical therapies vary. GnRH agonists are expensive and may cause bone loss. Selective progesterone receptor modulators can cause headaches and breast tenderness. UAE increases the risk of amenorrhea and pregnancy complications.
  • #1 Uterine Fibroid Treatment | The University of Kansas Health System
    https://www.kansashealthsystem.com/care/conditions/fibroids
    Fibroids are benign tumors in the uterus. […] While some women are not bothered by their fibroids, the location and size of fibroid tumors can cause symptoms that can affect a womans quality of life, including impacting fertility. However, there are treatment options that can help. The physicians at The University of Kansas Health System specialize in diagnosing and treating uterine fibroids with the most advanced and least invasive treatment options. […] Fibroids that dont cause symptoms may not require any treatment other than watchful waiting. Many women use over-the-counter pain medications to manage the painful symptoms of uterine fibroids. […] Other possible fibroid treatment options include: Endometrial ablation is a procedure that destroys the endometrium (uterine lining) with the goal of reducing menstrual flow. In some women, menstrual flow may stop completely. Women with fibroids should only consider endometrial ablation as a treatment option if they have small (less than 1 inch in diameter) submucosal fibroids.
  • #1
    https://www.nhs.uk/conditions/fibroids/treatment/
    A hysterectomy may be recommended if you have large fibroids or severe bleeding and do not wish to have any more children. […] A myomectomy is surgery to remove the fibroids from the wall of your womb. […] A hysteroscopic resection of fibroids is a procedure where a thin telescope (hysteroscope) and small surgical instruments are used to remove fibroids. […] Uterine artery embolisation (UAE) is an alternative procedure to a hysterectomy or myomectomy for treating fibroids. […] Endometrial ablation is a relatively minor procedure that involves removing the lining of the womb. […] Transcervical ultrasound-guided radiofrequency ablation is a new procedure that uses heat to shrink fibroids.
  • #1 Uterine Fibroid Treatments, UFE, MRgFUS
    https://www.radiologyinfo.org/en/info/uterine-fibroid-treatment
    Uterine fibroids are abnormal, benign growths in the uterus. These non-cancerous lesions, also known as myomas, arise from the muscular wall of the uterus. It is extremely rare for fibroid tumors to become cancerous. […] Minimally invasive uterine fibroid treatments include: Uterine fibroid embolization (UFE) and Magnetic resonance-guided focused ultrasound (MRgFUS). […] Uterine fibroid embolization (UFE) (also known as UAE or Uterine Artery Embolization) shrinks uterine fibroids by depriving them of a blood supply using small particles called embolic agents. […] In UFE, the doctor uses fluoroscopy to inject the agents through a catheter and into the arteries that supply blood to the fibroids. The small particles block blood flow to the fibroids and cause them to shrink. Nearly 90 percent of patients with fibroids who undergo UFE experience relief from their symptoms.
  • #1 Fibroid Treatment Options – Brigham and Women’s Hospital
    https://www.brighamandwomens.org/obgyn/infertility-reproductive-surgery/cysts-and-fibroids/non-surgical-fibroid-treatment
    Uterine fibroid embolization (UFE), also known as uterine artery embolization(UAE) is an alternative to surgery that involves placing a catheter through a small incision in the groin into an artery in the leg and guiding the catheter via x-ray pictures to the arteries of the uterus. Once there, the catheter is used to deliver agents that block off the blood vessels that feed the uterine fibroids. Total radiation exposure during this procedure is comparable to that in one to two CT scans. UAE does not remove uterine fibroids, but causes them to shrink by 30 to 50 percent. […] MRI-guided focused ultrasound (FUS) is a noninvasive treatment option for uterine fibroids that destroys fibroids while preserving the normal uterus. Focused high-frequency, high-energy sound waves are used to target the proteins in fibroids, until they are destroyed. Used in combination with MRI, FUS allows physicians to precisely target and monitor therapy. A single treatment session lasts approximately 3 hours. Although fibroids are treated and ultimately decrease in size, they are not removed. Women are able to resume normal activity within a day of the procedure, however the long-term effectiveness of this treatment is not known and it is not recommended for women who want to preserve their fertility.
  • #1 Best Treatment For Uterine Fibroids in Denver & Pueblo Colorado | Uterine Artery Embolization | ECCO Medical
    https://eccomedical.com/conditions/uterine-fibroid-treatment/
    UFE has large volumes of data showing it is as effective as surgery, and more effective than myomectomy in some cases. There is also significantly less risk and shorter recovery time than surgical options. An added bonus is that it doesnt need to be done in a hospital. It is up to patients to review these treatment options and determine what the best treatment option is for their fibroids. Those in their childbearing years should strongly consider non-surgical options, and those that would rather not undergo the risks of surgery should strongly consider UFE. […] UFE is performed at ECCO Medicals endovascular clinics in Pueblo and Denver. It is done as an outpatient. Patients do not need general anesthesia for this procedure. We use moderate sedation to keep patients comfortable throughout the treatment. It typically takes about 1-1.5 hours, with an hour of recovery afterwards.
  • #1 Uterine Fibroid Treatments, UFE, MRgFUS
    https://www.radiologyinfo.org/en/info/uterine-fibroid-treatment
    Follow-up studies have shown that nearly 90 percent of patients who have their fibroids treated by UFE experience either significant or complete resolution of their fibroid-related symptoms. […] MRgFUS may provide rapid improvement of symptoms associated with uterine fibroids without invasive surgery. […] The procedure has a low risk of complications. […] MRgFUS preserves the uterus. A number of patients have had successful pregnancies after MRgFUS treatment for uterine fibroids. […] UFE should not be performed in patients who have no symptoms from their fibroid tumors, when cancer is a possibility, or when there is inflammation or infection in the pelvis. […] MRgFUS may not be a good choice for some patients, including pregnant patients, patients with multiple abdominal scars, patients with many fibroids or very large fibroids.
  • #1 Get Uterine Fibroid Treatment | Cleveland Clinic
    https://my.clevelandclinic.org/services/uterine-fibroids-treatment
    Radiofrequency ablation (RFA): This minimally invasive procedure applies heat directly into the fibroids. This causes the fibroids to shrink over time and reduces symptoms. RFA may be done vaginally or laparoscopically depending on the size, number and location of the fibroids. […] Whether its miserable periods or pain, fibroids can pull you away from your active life. The good news? You can work with our team of experts to create a treatment plan thatll work for you. With treatment, comes relief from symptoms that get in the way of the life you want to live.
  • #1 Uterine fibroids
    https://womenshealth.gov/a-z-topics/uterine-fibroids
    A needle is inserted into the fibroids, usually guided by laparoscopy, and electric current or freezing is used to destroy the fibroids. […] A thin tube is thread into the blood vessels that supply blood to the fibroid. Then, tiny plastic or gel particles are injected into the blood vessels. This blocks the blood supply to the fibroid, causing it to shrink. […] The following methods are not yet standard treatments, so your doctor may not offer them or health insurance may not cover them. […] Radiofrequency ablation uses heat to destroy fibroid tissue without harming surrounding normal uterine tissue. The fibroids remain inside the uterus but shrink in size. Most women go home the same day and can return to normal activities within a few days. […] Anti-hormonal drugs may provide symptom relief without bone-thinning side effects.
  • #1 Uterine Fibroids | Wide Range of Treatment Options :: Minnesota Women’s Care OBGYN and Urogynecology
    https://mnwcare.com/our-services/gynecology/fibroids-treatments
    Laparoscopic radiofrequency fibroid ablation (Lap-RFA, brand name Acessa) is a minimally invasive, energy-based treatment that reduces fibroid-related symptoms by reducing fibroid volume. This procedure is laparoscopic, meaning performed through several small incisions in the abdomen, and is performed on an outpatient basis with quick recovery. […] After one year, the size of the fibroid decreases by up to 66%, resulting in a significant reduction in pelvic pain, heavy periods, and bulk. […] Pregnancy data on Lap-RFA is limited, as it is a newer technology and most studies have excluded patients planning for pregnancy. For this reason, should be used with caution if pregnancy is desired.
  • #1 Uterine fibroids – Diagnosis and treatment – Mayo Clinic
    https://www.mayoclinic.org/diseases-conditions/uterine-fibroids/diagnosis-treatment/drc-20354294
    There’s no single best treatment for uterine fibroids. Many treatment choices exist. If you have symptoms, talk with your care team about ways to get relief. […] Many people with uterine fibroids have no symptoms. Or they have mildly annoying symptoms that they can live with. If that’s the case for you, watchful waiting could be the best option. […] Medicines for uterine fibroids target hormones that control the menstrual cycle. They treat symptoms such as heavy menstrual bleeding and pelvic pressure. They don’t get rid of fibroids, but they may shrink them. […] During focused ultrasound surgery, high-frequency, high-energy sound waves are used to target and destroy uterine fibroids. The procedure is performed while you’re inside an MRI scanner. […] During laparoscopic radiofrequency ablation, the doctor sees inside the abdomen using two special instruments.
  • #1 Uterine Fibroids – Focused Ultrasound Foundation
    https://www.fusfoundation.org/diseases-and-conditions/uterine-fibroids/
    Focused ultrasound treatment for uterine fibroids has been available to women in the U.S. since a treatment system was approved by the Food and Drug Administration (FDA) in 2004. […] Focused ultrasound is a noninvasive way to treat uterine fibroids. Using this treatment method in conjunction with image guidance, the physician directs a focused beam of energy through the patients skin, superficial fat layer, and abdominal muscles to heat and destroy the fibroid tissue without damaging nearby tissue or the tissues that the beam passes through on its way to the target. […] It is a noninvasive treatment with a short recovery time and a quick return to work and activities of normal life (usually the next day). […] It offers rapid and durable resolution of fibroid symptoms (sometimes within days of treatment).
  • #1 No “best” treatment for common uterine fibroids – Harvard Health
    https://www.health.harvard.edu/blog/no-best-treatment-for-common-uterine-fibroids-201504237918
    I consider the severity of symptoms and the impact of those symptoms on a womans quality of life to be the foundation of treatment decision making, says Dr. Aaron Styer, an obstetrician-gynecologist at Harvard-affiliated Massachusetts General Hospital. For example, is the woman missing work, requiring frequent hospitalizations, or missing out on normal, daily life? If so, that information will guide the treatment I recommend. […] Whether a woman would like to have children, her age, and how close she is to menopause can also influence the treatment decision. Once a woman enters menopause, fibroids often shrink or even disappear. But until menopause, they may continue to form or reappear after they are removed. […] Hysterectomy, hold the power morcellation […] Removal of the uterus (hysterectomy) is a popular option for women who are done having children. With the uterus gone, new fibroids cant form. But traditional hysterectomy, in which a surgeon makes a large incision in the abdomen, is major surgery.
  • #1
    https://myhealth.alberta.ca/Health/pages/conditions.aspx?hwid=tv7259
    It’s possible but not likely for you to get pregnant while taking GnRH-a. If you don’t want to get pregnant, ask your doctor about birth control. […] GnRH-a therapy is not usually used to relieve pain and bleeding only, because fibroids grow back fairly quickly after you stop taking GnRH-a. But it is sometimes used to shrink large fibroids before fibroid surgery or to stop heavy bleeding from fibroids. […] For people who are close to menopause (when fibroids will shrink on their own), short-term relief from GnRH-a therapy can be a good choice. […] You have severe bleeding from uterine fibroids and need treatment right away. […] Other treatments for fibroids haven’t helped your symptoms, and you’re planning surgery later. […] You’re close to menopause, when fibroids will get smaller or go away. […] You’re planning to have surgery to take out large fibroids. […] You’re not planning on getting pregnant soon.
  • #1 Best Treatment For Uterine Fibroids in Denver & Pueblo Colorado | Uterine Artery Embolization | ECCO Medical
    https://eccomedical.com/conditions/uterine-fibroid-treatment/
    Yes! We can perform UFE regardless of the size or number of fibroids present. This procedure has been successfully used to treat fibroids of all sizes, from small to very large, and in cases where multiple fibroids are present. In fact, UFE is often preferred for women with large or multiple fibroids, since it is less invasive and because of the shorter recovery time.
  • #1 Boston Fibroid Treatment Options – Brigham and Women’s Hospital
    https://www.brighamandwomens.org/obgyn/resources/fibroid-treatment
    Fibroid treatment is highly personalized and depends on a number of factors, including severity of symptoms, size of the fibroids, and desire for fertility preservation. Asymptomatic fibroids may not require any treatment. On the other hand, fibroids that cause infertility or debilitating symptoms may be treated with a range of options. Here are a few examples of fibroid treatments: […] The latest surgical treatments for fibroids include minimally invasive (laparoscopic and robotic) surgical techniques, which offer smaller incisions and faster recovery than open surgical techniques. These procedures should be performed by a gynecologic surgeon who is experienced in minimally invasive techniques. Examples of surgical treatments for fibroids include: […] Myomectomy Fibroids that interfere with fertility in women who want to become pregnant are often surgically removed in a procedure called a myomectomy. Some women that have completed childbearing may also want to preserve their uterus intact and opt for this conservative option.
  • #1 Management of Uterine Fibroids | AAFP
    https://www.aafp.org/pubs/afp/issues/2019/0301/p330.html
    What are the comparative effectiveness and harms of treatments for uterine fibroids, and what is the risk of finding unexpected leiomyosarcoma in women with fibroids? […] Medical therapy (gonadotropin-releasing hormone [GnRH] agonists, mifepristone, ulipristal) or uterine artery embolization (UAE) reduces fibroid size (Strength of Recommendation [SOR]: C, based on disease-oriented evidence), reduces bleeding (SOR: A, based on consistent, good-quality patient-oriented evidence), and improves fibroid-related quality of life (SOR: A, based on consistent, good-quality patient-oriented evidence). […] The review found consistent evidence that UAE is effective for reducing fibroid size and uterine volume. […] There was moderate strength of evidence that GnRH agonists, mifepristone, and ulipristal also reduce fibroid size.
  • #1 Current medical treatment of uterine fibroids
    https://pmc.ncbi.nlm.nih.gov/articles/PMC5854898/
    Uterine fibroids (leiomyomas or myomas), benign monoclonal tumors, are the most common benign tumors in women. […] Although curative treatment of this tumor relies on surgical therapies, medical treatments are considered the first-line treatment to preserve fertility and avoid or delay surgery. […] Treatment options for symptomatic uterine fibroids include medical, surgical, and radiologically guided interventions. Various medical therapies are now available for women with uterine fibroids, although each therapy has its own advantages and disadvantages. Currently, gonadotrophin-releasing hormone (GnRH) agonists and selective progesterone receptor modulators (SPRMs) are the most effective medical therapies, with the most evidence to support their reduction of fibroid volume and symptomatic improvement in menstrual bleeding.
  • #1 Current medical treatment of uterine fibroids
    https://pmc.ncbi.nlm.nih.gov/articles/PMC5854898/
    Hysterectomy was considered the only curative solution for fibroids; however, alternate medical treatments that preserve fertility and avoid invasive surgery, with high efficacy, and a desirable side effect profile are now available. […] The cyclic use of progestins for bleeding control has been used in cases of non-organic abnormal uterine bleeding, such as perimenopausal bleeding and endometrial hyperplasia-related bleeding. […] In 2009, the Food and Drug Administration (FDA) approved the LNG-IUS to treat heavy menstrual bleeding in women who opt for an intrauterine device for contraception. […] GnRH agonists have been most extensively studied for the treatment of symptomatic uterine fibroids, especially adjuvant preoperative medical therapy. […] Despite FDA approval, menopausal symptoms, such as hot flashes and atrophic vaginitis, and a decrease in bone mineral density (BMD) after long-term use limit GnRH agonists to short-term adjuvant therapy in most patients.
  • #1 Leading-Edge Fibroid Diagnostic Services and Treatment Options
    https://www.upmc.com/services/womens-health/services/obgyn/gynecology/fibroid-treatment
    Myomectomy can cause large blood loss during surgery and scar tissue development in the muscle of your uterus and other places in your abdomen. […] If youre having a procedure or surgery to remove your fibroids, your doctor will talk to you about how to prepare. […] Your recovery will also depend on the type of treatment you received, the size and location of your fibroids, and your health history. Its normal to experience some pain for a few days after surgery. Your doctor will give you medications to ease the pain.
  • #1 No “best” treatment for common uterine fibroids – Harvard Health
    https://www.health.harvard.edu/blog/no-best-treatment-for-common-uterine-fibroids-201504237918
    In laparascopic hysterectomy, the surgeon removes the uterus through three or four small incisions in the wall of the abdomen. Recovery is quicker and there are usually fewer complications than with a traditional hysterectomy. […] Laparoscopic hysterectomy has historically been accompanied by a procedure called power morcellation. It uses a device to cut the uterus into fragments so it can be removed through the small incisions. But the FDA recently recommended limiting the use of power morcellation because of the small chance that a woman having surgery to remove fibroids may have undiagnosed uterine cancer. If power morcellation is performed in these women, there is a risk that the procedure will spread the cancer throughout the abdomen and pelvis. […] Treatment options for heavy bleeding
  • #1 Uterine Fibroids: What Treatments Are Available > News > Yale Medicine
    https://www.yalemedicine.org/news/uterine-fibroids-treatments
    Women can also choose to have uterine artery embolization, which is noninvasive and offers a faster recovery than surgery, says Hamid Mojibian, MD, a Yale Medicine interventional radiologist. […] Yale also offers a new uterine fibroid treatment method called laparoscopic radiofrequency ablation, in which heat is used to significantly shrink the fibroid. […] At Yale, our interventional radiologists, gynecologists, and primary care physicians all work together to help make the best treatment plan for our patients, Dr. Mojibian says.
  • #1 Treatment for uterine fibroids often depend on patient preferences
    https://www.uabmedicine.org/news/treatment-options-for-uterine-fibroids-often-depend-on-patient-preferences/
    In addition to hysterectomy, three of the most common treatments include: Myomectomy: Performed by an OB/GYN, this is a surgical option for removing fibroids, usually when they are larger and small in number. […] Radiofrequency ablation: With this minimally invasive procedure, doctors use heat from radiofrequency waves to destroy fibroid tissue. […] Uterine fibroid embolization (UFE): Performed by an interventional radiologist, this minimally invasive procedure involves starving the fibroids of the blood flow they need to survive. […] We have the advantage of being able to counsel our patients on all options, which we offer in house, whether they come in through a UAB OB/GYN, a referral from UAB Interventional Radiology, from another physician, or self-referral, Dr. Caridi said.
  • #1 Treatment for uterine fibroids often depend on patient preferences
    https://www.uabmedicine.org/news/treatment-options-for-uterine-fibroids-often-depend-on-patient-preferences/
    Treatment for fibroids can be complex. It may require you to communicate with multiple specialists to determine the best course of action, according to Todd Jenkins, M.D., an OB/GYN physician at UAB Medicine. […] Many women are only offered a hysterectomy removing the entire uterus as treatment for their uterine fibroids, Dr. Jenkins said. A hysterectomy can eliminate fibroids permanently, and it is an effective treatment option. But for many women, it may not be their only solution or their best option based on their personal situation or goals. […] At UAB Medicine, we have several effective treatment options for uterine fibroids. Unfortunately, many women are not aware of all of their options. […] We have several viable options for fibroids beyond hysterectomy, Dr. Jenkins said. Choosing among these requires clear patient communication and discussions with our radiology colleagues.
  • #1 Center for the Advanced Treatment and Research (CATeR) of Uterine Fibroids – UChicago Medicine
    https://www.uchicagomedicine.org/conditions-services/obgyn/uterine-fibroids
    At the Center for the Advanced Treatment and Research (CATeR) of Uterine Fibroids, we dont subscribe to a one size fits all approach to fibroid treatment. Well build a customized treatment plan that is tailored to your unique needs and designed to improve your quality of life. Our main goal is to support you in managing your fibroids, so your fibroids dont manage you. […] Our team of experts at the University of Chicago Medicine have a history of exceptional outcomes even for fibroids that are the most challenging to remove, shrink or treat. We work with you to discuss all your treatment options and will help champion the option that allows you to achieve your lifestyle goals. […] Choosing the right treatment option is a personal decision. Well discuss your short-term and long-term health goals and help you understand the benefits and risks as you consider your options.
  • #1 Center for the Advanced Treatment and Research (CATeR) of Uterine Fibroids – UChicago Medicine
    https://www.uchicagomedicine.org/conditions-services/obgyn/uterine-fibroids
    At the CATeR Fibroid Center, our team diagnoses and treats fibroids with the highest level of training and experience. From oral medication and alternative management options to minimally invasive surgery, we have the skill and expertise to personalize an effective care plan for you. […] You dont have to choose between getting treatment and having a family. Our gynecology, fertility and high-risk pregnancy specialists help patients who are pregnant, trying to become pregnant or wanting to preserve their fertility achieve their family building goals. […] In addition to providing the best care possible today, our physician scientists are exploring ways to improve fibroid treatment options for generations to come.
  • #1 Engineering Smart Therapeutics: Innovative Uterine Fibroid Treatment | Duke Department of Obstetrics and Gynecology
    https://obgyn.duke.edu/blog/engineering-smart-therapeutics-innovative-uterine-fibroid-treatment
    A collaboration by researchers at Duke and North Carolina Central University (NCCU) aims to offer a more convenient, less invasive treatment for uterine fibroids, one of the most common and under-studied issues in women’s health. […] Dr. Jayes has long been fascinated with this problem and is involved in developing a new therapeutic treatment using a drug capable of breaking fibroids down inside the body. Since the tumors are collagen-based, the key ingredient in this intervention is collagenase, an enzyme that digests collagen. […] The combination of LiquoGel and the collagenase drug, by contrast, could be administered in a doctor’s office and would act only on the tumor itself. […] The team has secured follow-on funding from North Carolina Biotechnology Center to conduct scale-up production of LiquoGel and time-course studies, as well as other essential research to facilitate the process of enabling clinical trials and ultimately seeking FDA authorization.
  • #1 Shrink Them, Zap Them, Starve Them: Newer, Minimally Invasive Fibroid Treatments Offer Hysterectomy Alternative | NYU Langone News
    https://nyulangone.org/news/shrink-them-zap-them-starve-them-newer-minimally-invasive-fibroid-treatments-offer-hysterectomy-alternative
    Two U.S. Food and Drug Administration (FDA)approved fibroid medications: Oriahnn and Myfembree, have been shown to significantly reduce heavy menstrual bleeding associated with uterine fibroids. […] Uterine fibroid embolization is a minimally invasive outpatient procedure performed by an interventional radiologist. […] One of the most common fibroid procedures, myomectomy is a minimally invasive surgery that removes fibroids through the abdomen with tiny, thumb-size incisions. […] Transcervical fibroid ablation, often performed using the Sonata System, is one of the newest tools in fibroid treatment. […] After the procedure, I felt a little cramping, but that was it. […] The Center for Fibroid Care is actively involved in research to improve fibroid management. […] Ultimately, we hope to better understand if LIFE can modify fibroid recurrence, says Dr. Shirazian.
  • #1 No “best” treatment for common uterine fibroids – Harvard Health
    https://www.health.harvard.edu/blog/no-best-treatment-for-common-uterine-fibroids-201504237918
    Which treatment is right for you? […] While there are many treatment options for uterine fibroids, there is no clear winner. That means you and your doctor can choose a treatment based on your preferences and reproductive plans along with other medical considerations. […] There may be no best treatment for uterine fibroids. But there is a best treatment for you.
  • #2 Uterine fibroids – Diagnosis and treatment – Mayo Clinic
    https://www.mayoclinic.org/diseases-conditions/uterine-fibroids/diagnosis-treatment/drc-20354294
    There’s no single best treatment for uterine fibroids. Many treatment choices exist. If you have symptoms, talk with your care team about ways to get relief. […] Many people with uterine fibroids have no symptoms. Or they have mildly annoying symptoms that they can live with. If that’s the case for you, watchful waiting could be the best option. […] Medicines for uterine fibroids target hormones that control the menstrual cycle. They treat symptoms such as heavy menstrual bleeding and pelvic pressure. They don’t get rid of fibroids, but they may shrink them. […] During focused ultrasound surgery, high-frequency, high-energy sound waves are used to target and destroy uterine fibroids. The procedure is performed while you’re inside an MRI scanner. […] During laparoscopic radiofrequency ablation, the doctor sees inside the abdomen using two special instruments.
  • #2 Currently Available Treatment Modalities for Uterine Fibroids
    https://pmc.ncbi.nlm.nih.gov/articles/PMC11205795/
    Treatment of fibroids must be individualized based on the presence and severity of symptoms and the patients desire for definitive treatment or fertility preservation. […] Treatment options for uterine fibroids include medicamentous, interventional radiology and surgical options. Generally, it is suggested that the treatment of fibroids begins with medicamentous and minimally invasive treatments before surgery. […] The medicamentous management of fibroids is typically reserved for patients with heavy menstrual bleeding and/or pelvic pain who wish to preserve their fertility. […] Medicamentous therapy yields effective results, and symptoms usually improve after one year of treatment. […] The levonorgestrel-releasing intrauterine system is a contraceptive method that is also ideal for the treatment of heavy menstrual bleeding in patients who have contraindications for COCs.
  • #2 Patient education: Uterine fibroids (Beyond the Basics) – UpToDate
    https://www.uptodate.com/contents/uterine-fibroids-beyond-the-basics/print
    Fibroids are very common. Approximately 80 percent of females will have fibroids in their lifetime, although not everyone has bothersome symptoms. Treatments are available for fibroid-related problems like heavy menstrual bleeding, pain or pressure in the pelvis, or problems with pregnancy or infertility. […] If your fibroids are not causing bothersome symptoms, you can choose not to have treatment. If you do have symptoms, your options include observation, medication, or surgical treatment. The best treatment depends on which symptom(s) is most bothersome to you. The size, number, and locations of fibroids, as well as whether or not you might want to get pregnant in the future, also factor into most treatment decisions. […] Most medications aim to reduce the heavy menstrual bleeding that is common in people with fibroids. A few also shrink the fibroid, and some are focused on reducing pain or correcting anemia. Medications are often recommended before surgical treatments.
  • #2 Get Uterine Fibroid Treatment | Cleveland Clinic
    https://my.clevelandclinic.org/services/uterine-fibroids-treatment
    Uterine Fibroids Treatment […] You have a range of options when it comes to uterine fibroid treatment. Before creating a treatment plan, we take the time to listen to your needs. We review your symptoms and discuss your goals for fertility preservation. […] […] We offer a wide range of medications to reduce pelvic pain, relieve heavy bleeding during periods and prevent anemia (a lack of iron in the blood). We may recommend: […] Birth control pills: Estrogen helps shorten periods and reduce heavy bleeding. […] Progestin-releasing intrauterine device (IUD): This hormone can reduce blood flow during periods, though an IUD may not be recommended for women with bulk fibroids. […] Tranexamic acid (Lysteda): We give this nonhormonal medication during your period to reduce blood loss. We may recommend it for women who cant have hormonal therapy.
  • #2
    https://www.nhs.uk/conditions/fibroids/treatment/
    The contraceptive pill is a popular method of contraception that stops an egg being released from the ovaries to prevent pregnancy. […] Oral progestogen is synthetic (man-made) progesterone (one of the female sex hormones) that can help reduce heavy periods. […] Progestogen is also available as an injection to treat heavy periods. […] If you’re still experiencing symptoms related to fibroids despite treatment with the above medicines, a GP can refer you to a gynaecologist. […] They may prescribe medicine called gonadotropin releasing hormone analogues (GnRHas) to help shrink your fibroids. […] GnRHas stop your menstrual cycle (period), but are not a form of contraception. […] Surgery to remove your fibroids may be considered if your symptoms are particularly severe and medicine has been ineffective.
  • #2 Current medical treatment of uterine fibroids
    https://pmc.ncbi.nlm.nih.gov/articles/PMC5854898/
    Hysterectomy was considered the only curative solution for fibroids; however, alternate medical treatments that preserve fertility and avoid invasive surgery, with high efficacy, and a desirable side effect profile are now available. […] The cyclic use of progestins for bleeding control has been used in cases of non-organic abnormal uterine bleeding, such as perimenopausal bleeding and endometrial hyperplasia-related bleeding. […] In 2009, the Food and Drug Administration (FDA) approved the LNG-IUS to treat heavy menstrual bleeding in women who opt for an intrauterine device for contraception. […] GnRH agonists have been most extensively studied for the treatment of symptomatic uterine fibroids, especially adjuvant preoperative medical therapy. […] Despite FDA approval, menopausal symptoms, such as hot flashes and atrophic vaginitis, and a decrease in bone mineral density (BMD) after long-term use limit GnRH agonists to short-term adjuvant therapy in most patients.
  • #2 Uterine Fibroids Treatments: 9 Options to Treat Uterine Fibroids
    https://www.webmd.com/women/uterine-fibroids/understanding-uterine-fibroids-treatment
    If you have uterine fibroids, you may or may not need treatment. It depends on whether they cause you any problems. […] You cant cure fibroids on your own. But you can do things that help you feel better. […] If you and your doctor decide you need to take something for your fibroids, you may want to consider these other options: […] To help prevent more growth of the fibroid, your doctor may recommend that you stop taking birth control pills or using hormone replacement therapy. […] GnRH antagonists put you into menopause for as long as you take them by suppressing estrogen, which stimulates fibroid growth. […] These work in a similar way to GnRH antagonists, but you get them as a shot. […] An IUD is a birth control device. Some also release the hormone progestin, which can help control the heavy bleeding and cramping that fibroids may cause.
  • #2 Current medical treatment of uterine fibroids
    https://pmc.ncbi.nlm.nih.gov/articles/PMC5854898/
    SPRMs have tissue-specific effects at PRs, and they can have either a complete PR agonist or antagonist profile or a mixed agonist/antagonist profile. […] Many clinical studies have evaluated the efficacy of UPA in the treatment of symptomatic uterine fibroids; however, the most widely cited studies investigating UPA include the European phase III studies, PGL4001 Efficacy Assessment in Reduction of Symptoms Due to Uterine Leiomyomata (PEARL), which demonstrate UPA’s safety and efficacy. […] Uterine fibroids are highly prevalent in reproductive-aged women, and as women continue to delay childbearing, an increasing number of patients will require fertility-preserving treatment options. Medical management of uterine fibroids may provide symptomatic relief of the uterine fibroid-related symptoms along with the opportunity to maintain fertility.
  • #2 Uterine Fibroids: Causes, Symptoms & Treatment
    https://my.clevelandclinic.org/health/diseases/9130-uterine-fibroids
    Myomectomy is a procedure that allows your provider to remove the fibroids. […] If you aren’t planning future pregnancies, there are additional options your healthcare provider may recommend. […] Hysterectomy is the only way to cure fibroids. […] Uterine fibroid embolization: An interventional radiologist performs this procedure with the help of your gynecologist. […] Radiofrequency ablation (RFA): This is a safe and effective treatment that uses microwave (RF) energy to treat uterine fibroids. […] Talk to your healthcare provider if you experience any kind of discomfort or pain. Fibroids are treatable.
  • #2 Uterine Fibroid Treatments, UFE, MRgFUS
    https://www.radiologyinfo.org/en/info/uterine-fibroid-treatment
    Doctors use UFE and MRgFUS to treat symptomatic fibroids in the uterus. These procedures are non-surgical alternatives to hysterectomy and myomectomy. […] MRgFUS helps preserve the uterus and the patient’s ability to become pregnant. […] UFE typically uses one or two x-ray tubes, a catheter, embolic agents, and a video monitor. […] UFE uses fluoroscopy to insert a catheter through the groin and guide it to the uterine arteries. Once the catheter is in place, the doctor will inject the embolic agents through the catheter and into the arteries to block the fibroids blood supply. […] The interventional radiologist performs UFE in a catheterization lab or occasionally in the operating room. This is may be an inpatient or outpatient procedure. […] Uterine fibroid embolization with local anesthesia is much less invasive than open or laparoscopic surgery to remove individual uterine fibroids (myomectomy) or the whole uterus (hysterectomy).
  • #2 Patient education: Uterine fibroids (Beyond the Basics) – UpToDate
    https://www.uptodate.com/contents/uterine-fibroids-beyond-the-basics/print
    Magnetic resonance-guided focused ultrasound surgery (MRgFUS or FUS) is also a fibroid treatment option. This noninvasive treatment takes place in an MRI machine, which guides the treatment. […] Endometrial ablation destroys the lining of the uterus. The treatment does not shrink the fibroid(s) but can help to decrease heavy menstrual bleeding caused by fibroids. […] Hysterectomy is a surgery that removes the uterus. The ovaries and cervix may be left in place when the hysterectomy is for uterine fibroids. Hysterectomy is a permanent treatment that cures heavy menstrual bleeding and the bulk of related symptoms of fibroids. However, it is major surgery, and you will need up to six weeks to fully recover.
  • #2 Uterine Fibroids: What Treatments Are Available > News > Yale Medicine
    https://www.yalemedicine.org/news/uterine-fibroids-treatments
    Women can also choose to have uterine artery embolization, which is noninvasive and offers a faster recovery than surgery, says Hamid Mojibian, MD, a Yale Medicine interventional radiologist. […] Yale also offers a new uterine fibroid treatment method called laparoscopic radiofrequency ablation, in which heat is used to significantly shrink the fibroid. […] At Yale, our interventional radiologists, gynecologists, and primary care physicians all work together to help make the best treatment plan for our patients, Dr. Mojibian says.
  • #2 Best Treatment For Uterine Fibroids in Denver & Pueblo Colorado | Uterine Artery Embolization | ECCO Medical
    https://eccomedical.com/conditions/uterine-fibroid-treatment/
    Uterine fibroids are smooth, muscular tumors that form on the interior walls of the uterus. These growths appear during womens childbearing years, and are so common that 30% of all women develop them by age 35, and as many as 70% to 80% of women develop them by age 50. Fortunately, these fibroids are non-cancerous, and do not increase a womans chances of developing uterine cancer. […] In the past, traditional treatment of uterine fibroids has involved hysterectomy (surgical removal of the uterus) or other forms of treatment that left the women incapable of becoming pregnant. At ECCO, we prefer a safer, gentler, minimally-invasive procedure called Uterine Fibroid Embolization, or UFE. During this procedure, your interventional radiologist introduces a thin catheter into the arteries that feed the fibroids, pinpointing their exact location via X-ray fluoroscopy. The doctor then injects a solution of embolizing particles into the arteries to close them, which causes the fibroids they feed to shrink and die. The UFE procedure is performed in our office-based laboratory on an outpatient basis. Because there are no incisions, there are few risks from the procedure itself, and the lack of trauma to the uterus means that you may retain your ability to become pregnant, if you so choose. Most patients report significant reductions of their reported symptoms, often as quickly as the next menstrual cycle.
  • #2 Fibroid Treatment Options – Brigham and Women’s Hospital
    https://www.brighamandwomens.org/obgyn/infertility-reproductive-surgery/cysts-and-fibroids/non-surgical-fibroid-treatment
    Uterine fibroid embolization (UFE), also known as uterine artery embolization(UAE) is an alternative to surgery that involves placing a catheter through a small incision in the groin into an artery in the leg and guiding the catheter via x-ray pictures to the arteries of the uterus. Once there, the catheter is used to deliver agents that block off the blood vessels that feed the uterine fibroids. Total radiation exposure during this procedure is comparable to that in one to two CT scans. UAE does not remove uterine fibroids, but causes them to shrink by 30 to 50 percent. […] MRI-guided focused ultrasound (FUS) is a noninvasive treatment option for uterine fibroids that destroys fibroids while preserving the normal uterus. Focused high-frequency, high-energy sound waves are used to target the proteins in fibroids, until they are destroyed. Used in combination with MRI, FUS allows physicians to precisely target and monitor therapy. A single treatment session lasts approximately 3 hours. Although fibroids are treated and ultimately decrease in size, they are not removed. Women are able to resume normal activity within a day of the procedure, however the long-term effectiveness of this treatment is not known and it is not recommended for women who want to preserve their fertility.
  • #2 Uterine Fibroids – Focused Ultrasound Foundation
    https://www.fusfoundation.org/diseases-and-conditions/uterine-fibroids/
    It has a low rate of complications. […] It preserves fertility with published studies reporting that women are able to conceive and have normal pregnancies after treatment. […] In 2004, MRI-guided focused ultrasound was approved by US Food and Drug Administration for the treatment of uterine fibroids. […] Internationally, focused ultrasound is approved in Canada, China, Europe, India, Japan, Korea, the Middle East, Oceania, Russia, South America, and Taiwan. […] In Israel, Clalit Medical Insurance is covering MRgFUS for symptomatic uterine fibroids. […] Ultrasound-guided high-intensity focused ultrasound for symptomatic uterine fibroids: clinical outcome of two European centers. […] Evaluating pregnancy outcomes in women with uterine fibroids treated with high-intensity focused ultrasound: insights from a single-institution study. […] The safety and efficacy of myomectomy in the treatment of recurrent uterine fibroids after HIFU. […] Predictive value of contrast-enhanced MRI for the regrowth of residual uterine fibroids after high-intensity focused ultrasound treatment.
  • #2 Boston Fibroid Treatment Options – Brigham and Women’s Hospital
    https://www.brighamandwomens.org/obgyn/resources/fibroid-treatment
    Hysterectomy (surgical removal of the uterus) also is commonly performed for patients with debilitating symptoms associated with uterine fibroids. It is not performed in women who want to become pregnant in the future. […] Non-surgical fibroid treatments include: […] Medications, such as gonadotropin releasing hormone agonists (GnRHa), cause a low-estrogen (menopause-like) state, which reduces the size of the tumor and uterus; these medications are prescribed in preparation for surgery in select cases. […] Uterine fibroid embolization/uterine artery embolization to deliver agents that block off the blood vessels that enable the uterine fibroids to grow; […] MRI-guided focused ultrasound (FUS) is a noninvasive treatment option for uterine fibroids that destroys fibroids, while preserving the normal uterus. Focused high-frequency, high-energy sound waves are used to target and destroy the fibroids.
  • #2 Currently Available Treatment Modalities for Uterine Fibroids
    https://pmc.ncbi.nlm.nih.gov/articles/PMC11205795/
    Selective Progesterone Receptor Modulators (SPRM) have been shown to diminish uterine fibroid volume by 17-57% and to reduce uterine mass by 95-93%. […] Myomectomy is a surgical treatment in which the fibroids are removed and the uterus is then reconstructed. […] Myomectomy improves symptoms in up to 80% of cases but is associated with about a 27% risk of recurrence if one fibroid is removed and a risk level greater than 50% in the case of multiple fibroids. […] A hysterectomy is the last treatment option for symptomatic fibroids. A hysterectomy is a definitive surgical treatment option that eliminates the risk of future recurrence. […] Symptomatic uterine fibroids require surgical and/or medical therapy according to the FIGO classification, severity of symptoms, patients age, infertility and wish to preserve fertility. Currently, the usual treatment for fibroids is surgical intervention, such as hysterectomy and/or fertility-sparing myomectomy performed via hysteroscopy, laparoscopy or laparotomy.
  • #2 What Are My Treatment Options for Uterine Fibroids? | Northwestern Medicine
    https://www.nm.org/healthbeat/healthy-tips/what-are-my-treatment-options-uterine-fibroids
    Uterine fibroids are fibrous, solid, noncancerous tumors of the uterus. They are also known as uterine leiomyomas or myomas. They’re common and may not require treatment. „If you are diagnosed with uterine fibroids and have no symptoms, there might be no need for treatment,” says Dr. Chaudhari. „Your physician may simply monitor their growth at your annual exams or more frequently if needed.” Your physician may recommend treatment if you: […] Myomectomy is a surgical procedure to remove fibroids while keeping the uterus in place. Myomectomy may reduce both bleeding and pressure symptoms. The goal of myomectomy is to keep the uterus for future fertility. […] New fibroids can grow back after surgery. Between 10% and 25% of patients who undergo myomectomy will need a second fibroid surgery during their reproductive years, and the timing of repeat surgeries varies. Myomectomy is considered the gold standard for patients who want to get pregnant in the future, but may not be right for everyone.
  • #2 Nonsurgical Fibroid Treatments | NYU Langone Health
    https://nyulangone.org/conditions/fibroids/treatments/nonsurgical-fibroid-treatments
    NYU Langone gynecologists, including the team at the Center for Fibroid Care, offer several nonsurgical treatment options that shrink fibroids without removing them. This reduces or eliminates symptoms, including heavy and painful periods, without the need for surgery. […] Our nonsurgical treatment options include transcervical radiofrequency ablation, endometrial ablation, and uterine fibroid embolization. […] Transcervical radiofrequency ablation, known by the brand name Sonata, is an incision-free procedure used to shrink fibroids and lessen symptoms. […] This procedure is most effective for people who have a few fibroids up to 5cm with symptomatic bleeding. […] During endometrial ablation, also known as NovaSure, heat energy is used to remove the lining of the uterus, which is the source of the heavy menstrual bleeding that accompanies fibroids.
  • #2 Uterine Fibroids | OB/GYN & Women’s Health Services | University Hospitals | University Hospitals
    https://www.uhhospitals.org/services/obgyn-womens-health/conditions-and-treatments/general-gynecology/fibroids
    Fibroids are growths or tumors made of smooth muscle cells and fibrous connective tissue that develop in the uterus. […] Treatment may be required when symptoms such as severe abdominal pain and excessive menstrual bleeding affect a woman’s quality of life. […] The team of gynecologists and interventional radiologists at University Hospitals offer the latest minimally invasive surgical and nonsurgical treatment options to treat uterine fibroids. […] Treatment plans are personalized based on the location and size of the fibroid, and fertility preservation preferences. […] While hysterectomy is the right choice for some patients, it is far from the only option. […] Women seeking treatment for uterine fibroids typically need to make appointments with several specialists to explore fibroid treatment options.
  • #2 Uterine Fibroid Clinic | Ohio State Medical Center
    https://wexnermedical.osu.edu/obstetrics-gynecology/gynecology/uterine-fibroids
    Transcervical radiofrequency ablation is one of the newest options for women dealing with symptomatic fibroids who dont want or cant have major surgery. […] Uterine fibroid embolization is not surgery, but a minimally invasive procedure that can shrink fibroids. […] Myomectomy is a surgical procedure that removes fibroids, but not the uterus, so its a good choice for women who hope to get pregnant or just want to keep their uterus. […] Hysterectomy is a surgery in which your uterus is removed, making it the only way to make sure that fibroids will not come back. […] If you have fibroids and plan to become pregnant or are currently pregnant, the specialized team at Ohio States Multidisciplinary Uterine Fibroid Clinic can partner with your fertility specialist or Ob/Gyn to determine the best treatment plan, monitor symptoms and minimize complications. […] Because we are part of one of the largest academic medical centers in the nation, you benefit from the most current therapy options and surgical techniques and the latest knowledge gained from our ongoing research on fibroid causes, complications and treatment.
  • #2 Center for the Advanced Treatment and Research (CATeR) of Uterine Fibroids – UChicago Medicine
    https://www.uchicagomedicine.org/conditions-services/obgyn/uterine-fibroids
    At the Center for the Advanced Treatment and Research (CATeR) of Uterine Fibroids, we dont subscribe to a one size fits all approach to fibroid treatment. Well build a customized treatment plan that is tailored to your unique needs and designed to improve your quality of life. Our main goal is to support you in managing your fibroids, so your fibroids dont manage you. […] Our team of experts at the University of Chicago Medicine have a history of exceptional outcomes even for fibroids that are the most challenging to remove, shrink or treat. We work with you to discuss all your treatment options and will help champion the option that allows you to achieve your lifestyle goals. […] Choosing the right treatment option is a personal decision. Well discuss your short-term and long-term health goals and help you understand the benefits and risks as you consider your options.
  • #3 Patient education: Uterine fibroids (Beyond the Basics) – UpToDate
    https://www.uptodate.com/contents/uterine-fibroids-beyond-the-basics/print
    Your doctor might recommend a surgical or interventional treatment for fibroids if: You have fibroid-related heavy menstrual bleeding, pain, or pressure that does not get better with medication; You are trying to get pregnant and fibroids appear to be interfering; The size of the fibroid is causing symptoms. […] Myomectomy is a surgery done to remove fibroids, which can reduce both bleeding and size-related symptoms. Myomectomy is often a good choice for people who might want to get pregnant in the future. […] Uterine artery embolization (UAE), also called uterine fibroid embolization (UFE), is a treatment that blocks the blood supply to fibroids. This causes the fibroid to shrink within weeks to several months after the treatment and decreases other fibroid symptoms including heavy menstrual bleeding.