Hiperpotliwość
Etiologia i przyczyny

Hiperpotliwość to stan charakteryzujący się nadmierną aktywnością gruczołów potowych, prowadzącą do produkcji potu przekraczającej potrzeby termoregulacyjne organizmu. Wyróżnia się dwa główne typy: pierwotną (idiopatyczną, ogniskową) oraz wtórną (uogólnioną). Hiperpotliwość pierwotna, często rozpoczynająca się przed 25. rokiem życia, ma podłoże neurogenne z nadreaktywnością autonomicznego układu współczulnego i wykazuje autosomalny dominujący wzorzec dziedziczenia, z 30-50% przypadków z dodatnim wywiadem rodzinnym. Objawia się symetrycznym, obustronnym poceniem głównie dłoni, stóp, pach i twarzy, bez nocnych potów, z epizodami co najmniej raz w tygodniu i znacznym upośledzeniem codziennych funkcji. Wtórna hiperpotliwość jest związana z szerokim spektrum chorób podstawowych, w tym zaburzeniami endokrynologicznymi (np. nadczynność tarczycy, cukrzyca, guzy chromochłonne), neurologicznymi (choroba Parkinsona, urazy OUN), infekcjami (gruźlica, HIV), nowotworami (chłoniaki, białaczka) oraz działaniem leków (m.in. SSRI, opioidy, leki przeciwpsychotyczne). Wtórna forma często obejmuje całe ciało i może występować również w nocy.

Etiologia hiperhidrości (Hyperhidrosis Etiology)

Hiperpotliwość (łac. hyperhidrosis) to nadmierne pocenie się, które nie zawsze jest związane z wysoką temperaturą otoczenia czy wysiłkiem fizycznym. Występuje, gdy gruczoły potowe są nadmiernie aktywne, produkując więcej potu niż jest to konieczne dla termoregulacji organizmu12. Etiologia tego schorzenia jest złożona i może się różnić w zależności od rodzaju hiperpotliwości.

Klasyfikacja hiperpotliwości

Hiperpotliwość dzieli się na dwa główne typy, które różnią się przyczynami oraz manifestacją kliniczną13:

  • Hiperpotliwość pierwotna (idiopatyczna, ogniskowa) – występuje bez uchwytnej przyczyny medycznej
  • Hiperpotliwość wtórna (uogólniona) – spowodowana przez inne choroby podstawowe, zaburzenia lub leki

Hiperpotliwość pierwotna – przyczyny i mechanizmy

Hiperpotliwość pierwotna charakteryzuje się nadmiernym poceniem występującym bez uchwytnej przyczyny medycznej. Zwykle rozpoczyna się w dzieciństwie lub okresie dojrzewania i może utrzymywać się przez całe życie45. Badania wskazują na kilka potencjalnych mechanizmów tego schorzenia:

Dysfunkcja układu nerwowego

Główną przyczyną hiperpotliwości pierwotnej jest prawdopodobnie wadliwe działanie układu nerwowego, zwłaszcza autonomicznego układu współczulnego, który kontroluje pocenie43. Nerwy przekazujące sygnały do gruczołów potowych stają się nadreaktywne, powodując ich nadmierną aktywację. W hiperpotliwości pierwotnej dochodzi do zwiększonej lub nieprawidłowej stymulacji współczulnej gruczołów potowych ekrynowych67.

U pacjentów z hiperpotliwością pierwotną występuje wyższy podstawowy poziom produkcji potu oraz zwiększona odpowiedź na normalne bodźce, takie jak stres emocjonalny czy fizyczny7. Problem dotyczy głównie gruczołów ekrynowych, które są licznie rozmieszczone na dłoniach, stopach, pod pachami i na twarzy, a unerwione są przez postgangliowe włókna nerwów autonomicznych i stymulowane przez neuroprzekaźnik acetylocholinę8.

Czynniki genetyczne

Badania sugerują istotną rolę czynników genetycznych w rozwoju hiperpotliwości pierwotnej910. Schorzenie to często występuje rodzinnie, co wskazuje na genetyczną predyspozycję:

  • Według danych statystycznych około 30-50% osób z hiperpotliwością pierwotną ma co najmniej jednego członka rodziny z tym samym schorzeniem1112
  • Hiperpotliwość pierwotna wydaje się mieć autosomalny dominujący wzorzec dziedziczenia, co oznacza, że wystarczy jedna kopia zmutowanego genu, aby schorzenie się ujawniło13
  • Mutacja genetyczna może prowadzić do zaburzenia instrukcji w komórkach kontrolujących normalne funkcjonowanie organizmu, co skutkuje zakłóceniem prawidłowego działania gruczołów potowych5

Mimo tych obserwacji, dokładny gen odpowiedzialny za hiperpotliwość pierwotną nie został jeszcze zidentyfikowany14.

Zaburzenia centralnej kontroli emocji

Część badaczy sugeruje, że hiperpotliwość pierwotna może być wynikiem zaburzeń centralnej kontroli emocji6. Emocje takie jak lęk, podekscytowanie, złość czy strach mogą wywoływać pocenie się na dłoniach, stopach, pod pachami i na czole15. U osób z hiperpotliwością pierwotną ten mechanizm może być nadreaktywny, prowadząc do nadmiernego pocenia się nawet przy niewielkim stresie emocjonalnym.

Hiperpotliwość wtórna – przyczyny

Hiperpotliwość wtórna rozwija się jako skutek innego schorzenia lub przyjmowanych leków1. W przeciwieństwie do hiperpotliwości pierwotnej, która zwykle dotyka określonych obszarów ciała, hiperpotliwość wtórna często obejmuje całe ciało i może występować również podczas snu16. Przyczyny hiperpotliwości wtórnej można podzielić na kilka kategorii:

Zaburzenia endokrynologiczne

Liczne zaburzenia hormonalne mogą powodować nadmierne pocenie17:

  • Nadczynność tarczycy (hipertyreoza) – zwiększona produkcja hormonów tarczycy przyspiesza metabolizm, co prowadzi do zwiększonej produkcji ciepła i nadmiernego pocenia1819
  • Cukrzyca – może powodować uszkodzenie autonomicznego układu nerwowego, w tym nerwów kontrolujących gruczoły potowe, co znane jest jako neuropatia cukrzycowa20
  • Hipoglikemia – niski poziom cukru we krwi może wyzwalać reakcję „walcz lub uciekaj”, co powoduje nadmierne pocenie20
  • Guzy chromochłonne (pheochromocytoma) – rzadkie guzy nadnerczy produkujące katecholaminy, które mogą powodować napady pocenia się, tachykardię i bóle głowy17
  • Akromegalia – zwiększony metabolizm spowodowany nadmierną produkcją hormonu wzrostu może prowadzić do zwiększonego pocenia termoregulacyjnego17
  • Hiperpituitaryzm – nadczynność przysadki mózgowej21
Zaburzenia neurologiczne

Różne schorzenia neurologiczne mogą wpływać na układ nerwowy kontrolujący pocenie22:

  • Choroba Parkinsona – może wpływać na część układu nerwowego kontrolującą pocenie, a nadmierne pocenie może nasilać się wraz z postępem choroby16
  • Uraz rdzenia kręgowego – ostry uraz rdzenia kręgowego zwykle prowadzi do utraty pocenia poniżej miejsca urazu, ale może również prowadzić do zlokalizowanych obszarów hiperpotliwości, które pojawiają się miesiące lub lata po urazie23
  • Urazy ośrodkowego układu nerwowego, takie jak udary prowadzące do zawałów półkulowych lub rdzeniowych, mogą prowadzić do hiperpotliwości po stronie ipsilateralnej i kontralateralnej23
  • Dystrofia współczulno-odruchowa – hiperpotliwość często występuje w dotkniętym obszarze24
  • Zespół Rileya-Daya (rodzinna dysautonomia) – może prowadzić do uogólnionej hiperpotliwości25
Infekcje i choroby zakaźne

Różne infekcje mogą prowadzić do hiperpotliwości25:

  • Gruźlica – najczęściej związana z nocnymi potami19
  • HIV – może powodować nadmierne pocenie, szczególnie w nocy26
  • Ostre infekcje bakteryjne lub wirusowe – mogą prowadzić do gorączki, a następnie nadmiernego pocenia2527
  • Endocarditiszapalenie wsierdzia28
Nowotwory

Różne rodzaje nowotworów mogą być związane z hiperpotliwością29:

  • Chłoniak (w tym chłoniak Hodgkina) – może powodować nadmierne pocenie, szczególnie w nocy30
  • Białaczka – związana z zaburzeniami komórek krwi i szpiku kostnego31
  • Guzy rakowiaka (prowadzące do zespołu rakowiaka)29
  • Guzy śródpiersia – guz wewnątrz klatki piersiowej uciskający pień współczulny lub nerwy pozazwojowe może powodować hiperpotliwość23
Zaburzenia sercowo-naczyniowe

Problemy z układem sercowo-naczyniowym mogą prowadzić do hiperpotliwości13:

  • Zawał serca – nadmierne pocenie jest jednym z najczęstszych objawów zawału1820
  • Niewydolność serca – może powodować wtórną hiperpotliwość jako objaw32
Zmiany hormonalne związane z menopauzą/ciążą

Zmiany hormonalne u kobiet mogą prowadzić do hiperpotliwości33:

  • Menopauza – uderzenia gorąca w okresie menopauzy mogą być związane z hiperpotliwością z powodu zmieniających się poziomów hormonów. Do 80% kobiet doświadcza pocenia i uderzeń gorąca do czasu zakończenia procesu menopauzy2527
  • Ciąża – zwiększona objętość krwi, zmiany hormonalne i dodatkowa waga mogą powodować u kobiety pocenie się bardziej niż zwykle34
Leki i substancje

Wiele leków i substancji może powodować hiperpotliwość jako działanie niepożądane3536:

  • Leki przeciwdepresyjne: selektywne inhibitory wychwytu zwrotnego serotoniny (SSRI) takie jak citalopram, trójpierścieniowe leki przeciwdepresyjne jak amitryptylina, selektywne inhibitory wychwytu zwrotnego noradrenaliny (SNRI) jak wenlafaksyna37
  • Leki przeciwpsychotyczne: takie jak haloperidol i klozapina37
  • Leki stosowane w leczeniu otępienia lub choroby Parkinsona: inhibitory acetylocholinoesterazy, takie jak donepezyl, które zwiększają pocenie poprzez bezpośrednią stymulację receptorów w gruczołach potowych37
  • Leki przeciwbólowe: opioidy takie jak morfina, oksykodon, fentanyl i tramadol; niesteroidowe leki przeciwzapalne (NLPZ) takie jak celekoksyb i naproksen37
  • Leki przeciwdrobnoustrojowe i antybiotyki: cefalosporyny (np. ceftriakson lub cefuroksym), antybiotyki chinolonowe (np. cyprofloksacyna), leki przeciwwirusowe (acyklowir lub rybawiryna)38
  • Leki wpływające na funkcje endokrynologiczne: kortykosteroidy systemowe, leki tarczycowe, leki przeciwcukrzycowe takie jak glipizyd i insulina38
  • Inne leki: propranolol, fizostygmina, pilokarpina35

Odstawienie substancji psychoaktywnych takich jak alkohol, kofeina i narkotyki także może powodować uogólnioną hiperpotliwość38.

Inne przyczyny hiperpotliwości wtórnej

Istnieją również inne czynniki, które mogą przyczynić się do rozwoju hiperpotliwości wtórnej32:

  • Otyłość – nadmierna masa ciała może powodować zatrzymywanie ciepła przez tkankę tłuszczową, uruchamiając naturalną reakcję chłodzenia organizmu i powodując nadmierne pocenie13
  • Dna moczanowa39
  • Zatrucie arsenem32
  • Alkoholizm32
  • Reumatoidalne zapalenie stawów39
  • Odmrożenia39

Hiperpotliwość ogniskowa (lokalna)

Warto podkreślić specyficzne rodzaje lokalizacji nadmiernego pocenia, gdyż mogą one wskazywać na określone przyczyny35:

  • Jednostronna lub segmentalna hiperpotliwość – rzadko występująca, o nieznanym pochodzeniu35
  • Ekrynowy naczyniak hamartoma – rzadka, łagodna wada rozwojowa charakteryzująca się zarówno komponentami ekrynowymi, jak i naczyniowymi35
  • Zespół Freya – schorzenie neurologiczne spowodowane urazem gruczołów przyusznych w wyniku operacji, infekcji lub urazu15
  • Pocenie smakowe (gustatory sweating) – zwiększone pocenie się na policzku lub części żuchwowej twarzy jednocześnie ze ślinotokiem24
  • Inne przyczyny ogniskowego pocenia – obejmują śluzak przedgoleniowy (golenie), hipertroficzną osteoartropatię (dłonie), zespół niebieskich pęcherzyków gumowatych (blue rubber bleb nevus) oraz guz chromochłonny (pheochromocytoma) (nad zmianami)15

Diagnoza przyczyn hiperpotliwości

Diagnostyka przyczyn hiperpotliwości jest szczególnie istotna w kontekście hiperpotliwości wtórnej, gdzie leczenie choroby podstawowej może zmniejszyć lub wyeliminować nadmierne pocenie40. Dokładna diagnoza przyczyn hiperpotliwości opiera się na kilku elementach41:

  • Szczegółowy wywiad medyczny
  • Badanie fizykalne
  • Badania laboratoryjne, takie jak badania krwi i moczu, w celu identyfikacji podstawowych stanów medycznych powodujących hiperpotliwość

W przypadku pierwotnej hiperpotliwości ogniskowej zaproponowano następujące kryteria diagnostyczne4243:

  • Ogniskowe, widoczne, nadmierne pocenie trwające co najmniej sześć miesięcy bez wyraźnej przyczyny
  • Co najmniej cztery z następujących cech:
    • Dotyczy głównie miejsc o dużej gęstości gruczołów ekrynowych (pachy/dłonie/stopy/twarz)
    • Występuje obustronnie i symetrycznie
    • Brak nocnego pocenia
    • Epizody występują co najmniej raz w tygodniu
    • Początek w wieku 25 lat lub wcześniej
    • Dodatni wywiad rodzinny
    • Upośledzenie codziennych aktywności

Hiperpotliwość rozpoczynająca się w późniejszym wieku powinna skłonić do poszukiwania przyczyn wtórnych, takich jak choroby układowe, niepożądane działanie leków lub zaburzenia metaboliczne44.

Gdy podejrzewa się hiperpotliwość wywołaną przez leki, należy ustalić związek czasowy między rozpoczęciem stosowania określonego leku a pojawieniem się objawów. Jeśli nie istnieje inna oczywista przyczyna wtórnej hiperpotliwości, sugeruje to hiperpotliwość wywołaną przez leki38.

Podsumowanie etiologii hiperpotliwości

Hiperpotliwość to złożone zaburzenie o wieloczynnikowej etiologii. Hiperpotliwość pierwotna prawdopodobnie wynika z dysfunkcji autonomicznego układu nerwowego prowadzącej do nadaktywności prawidłowych gruczołów potowych, z istotnym komponentem genetycznym69. Hiperpotliwość wtórna ma różnorodne przyczyny, w tym zaburzenia endokrynologiczne, neurologiczne, infekcje, nowotwory oraz leki45.

Zrozumienie przyczyn hiperpotliwości jest kluczowe dla właściwego podejścia terapeutycznego. W przypadku hiperpotliwości wtórnej leczenie choroby podstawowej lub odstawienie leku powodującego objawy może znacząco zmniejszyć lub całkowicie wyeliminować nadmierne pocenie38. W przypadku hiperpotliwości pierwotnej, gdzie przyczyna pozostaje nieznana, terapia koncentruje się na łagodzeniu objawów i poprawie jakości życia pacjenta7.

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  1. 10.04.2026
  2. www.leksykon.com.pl

Materiały źródłowe

  • #1 Hyperhidrosis – Symptoms and causes – Mayo Clinic
    https://www.mayoclinic.org/diseases-conditions/hyperhidrosis/symptoms-causes/syc-20367152
    Hyperhidrosis is excessive sweating that’s not always related to heat or exercise. […] Heavy sweating can disrupt your day and cause social anxiety and embarrassment. […] Sometimes an underlying condition may be found and treated. […] Primary hyperhidrosis is caused by faulty nerve signals that trigger eccrine sweat glands to become overactive. It usually affects the palms, soles, underarms and sometimes the face. […] There is no medical cause for this type of hyperhidrosis. It can run in families. […] Secondary hyperhidrosis is caused by an underlying medical condition or by taking certain medications, such as pain relievers, antidepressants, and some diabetes and hormonal medications. […] Conditions that might cause it include: Diabetes, Menopause hot flashes, Thyroid problems, Some types of cancer, Nervous system disorders, Infections.
  • #2 Hyperhidrosis: Types, Causes, Symptoms & Treatment
    https://my.clevelandclinic.org/health/diseases/17113-hyperhidrosis
    Hyperhidrosis is the result of your sweat glands overworking. […] Overactive sweat glands cause hyperhidrosis. Your eccrine glands (sweat glands) create sweat to cool down your body when you get hot. This process activates when you exercise or if you’re nervous. If you have hyperhidrosis, your eccrine glands activate and produce sweat more often than when your body is too hot. You may experience sweating at random times of the day when there isn’t something like an activity or emotion causing your glands to produce sweat. Research is ongoing to learn more about why your glands make too much sweat. […] Hyperhidrosis (generalized) could be a sign of an underlying medical condition including but not limited to: Acromegaly, An infection (tuberculosis), Anxiety, Cancer, Diabetes, Heart disease or heart failure, Hyperthyroidism, Menopause, Obesity, Parkinson’s disease. […] Yes, you may be more at risk of hyperhidrosis, specifically focal hyperhidrosis, if someone in your biological family has the condition. Research indicates that a hereditary genetic mutation or change to your DNA could cause hyperhidrosis.
  • #3 Hyperhidrosis | NHS inform
    https://www.nhsinform.scot/illnesses-and-conditions/skin-hair-and-nails/hyperhidrosis/
    Hyperhidrosis can be divided into 2 types, depending on whether an obvious cause can be identified. These are known as primary and secondary hyperhidrosis. […] In many cases, hyperhidrosis has no obvious cause and is thought to be the result of a problem with the part of the nervous system that controls sweating. This is known as primary hyperhidrosis. […] Hyperhidrosis that does have an identifiable cause is known as secondary hyperhidrosis. This can have many different triggers, including: pregnancy or the menopause, anxiety, certain medications, low blood sugar (hypoglycaemia), an overactive thyroid gland (hyperthyroidism), infections. […] Although its not clear why it develops, its thought to be the result of a problem with part of the nervous system called the sympathetic nervous system, and its possible your genes may also play a role.
  • #4 Hyperhidrosis: Causes
    https://www.aad.org/public/diseases/a-z/hyperhidrosis-causes
    Hyperhidrosis is a treatable medical condition that makes people sweat excessively. They sweat more than is needed to cool their body. […] The cause depends on the type of hyperhidrosis you have. There are two types of hyperhidrosis: Primary hyperhidrosis and Secondary hyperhidrosis. […] Its believed that this type of excessive sweating is caused by faulty signals coming from certain nerves, which tell the body when to sweat. Its possible that these nerves over-react, which leads to excessive sweating. […] If youve been diagnosed with secondary hyperhidrosis, the excessive sweating is usually due to one of the following: A medication youre taking or Another medical condition you have. […] Medical conditions that can cause hyperhidrosis include diabetes, Parkinsons disease, and rheumatoid arthritis. Heart failure and stroke can also cause secondary hyperhidrosis, as can menopause.
  • #5 Azthena logo with the word Azthena
    https://www.news-medical.net/health/Hyperhidrosis-Causes.aspx
    Hyperhidrosis is classified into 2 types, based on whether the reason behind the condition can be found. The 2 types are primary hyperhidrosis or secondary hyperhidrosis and these are described in more detail below. […] Primary hyperhidrosis is the term used when no obvious identifiable cause for the excessive sweating can be identified. The condition is thought to be caused by an issue in the sympathetic nervous system (SNS), which regulates sweating. In this case, it is possible that there may be a genetic element to the condition. […] It is possible that a hereditary element involving genetic mutation may be the cause of primary hyperhidrosis, since it appears to run in some families. When genetic mutation occurs, the instructions in the cells that control the normal body function become scrambled, resulting in disruption of the body’s usual workings.
  • #6 The etiology, diagnosis, and management of hyperhidrosis: A comprehensive review: Etiology and clinical work-up – PubMed
    https://pubmed.ncbi.nlm.nih.gov/30710604/
    Hyperhidrosis (HH) is a dermatologic disorder defined by sweat production exceeding thermoregulatory needs. […] The etiology of HH may stem from a complex autonomic nervous system dysfunction, resulting in neurogenic overactivity of otherwise normal eccrine sweat glands. […] Alternatively, HH may be a result of aberrant central control of emotions. […] This condition is categorized as primary or secondary HH. […] Secondary causes of HH need to be excluded before diagnosing primary HH.
  • #7 Hyperhidrosis: Management Options | AAFP
    https://www.aafp.org/pubs/afp/issues/2018/0601/p729.html
    Hyperhidrosis is excessive sweating that affects patients’ quality of life, resulting in social and work impairment and emotional distress. Primary hyperhidrosis is bilaterally symmetric, focal, excessive sweating of the axillae, palms, soles, or craniofacial region not caused by other underlying conditions. Secondary hyperhidrosis may be focal or generalized, and is caused by an underlying medical condition or medication use. […] The cause of primary hyperhidrosis is not well understood. Eccrine sweat glands distributed throughout the body, but heavily concentrated on the palms, soles, axillae, and face are innervated by postganglionic autonomic nerve fibers and stimulated by the neurotransmitter acetylcholine. It is thought that increased or aberrant sympathetic stimulation of the eccrine sweat glands is responsible for the increased sweating rather than an increased number or size of the glands. […] Persons with primary hyperhidrosis have a higher-than-normal basal level of sweat production and an increased response to normal stimuli, such as emotional or physical stress.
  • #8 Causes of Excessive Sweating: Primary and Secondary Hyperhidrosis
    https://www.webmd.com/skin-problems-and-treatments/hyperhidrosis-causes-11
    Hyperhidrosis happens when your sweat glands stay on even when you don’t need sweat to cool you down. […] The causes of hyperhidrosis depend on the type of sweating thats happening. […] In some cases, doctors dont know why people sweat too much. In other cases, the causes of hyperhidrosis may be a medical condition. […] People with primary hyperhidrosis generally sweat from a certain type of gland called eccrine sweat glands. […] Doctors aren’t sure why people have primary hyperhidrosis, although it may be related to the genes you carry. […] Why does it happen? Experts aren’t sure, but primary focal hyperhidrosis seems to stem from a minor malfunction in the sympathetic nervous system. […] This less common form of hyperhidrosis causes sweating all over the body not just on the hands or feet.
  • #9 Hyperhidrosis: Symptoms, causes, diagnosis, and treatment
    https://www.medicalnewstoday.com/articles/182130
    Hyperhidrosis is a condition characterized by excessive sweating. […] Hyperhidrosis may be present from birth or might develop later in life. However, most cases occur in people between the ages of 20 and 60. […] Primary idiopathic hyperhidrosis is a type of the condition that has no apparent cause. In contrast, secondary hyperhidrosis occurs due to an underlying health condition. […] Researchers do not fully understand what causes primary hyperhidrosis, although they believe genetics may play a role. […] The review suggests a strong genetic basis for primary hyperhidrosis because a family history of the condition increases a persons risk. […] Secondary hyperhidrosis may occur due to the following factors: medications, such as antibiotics, antidepressants, insulin, certain topical therapies; systemic conditions, such as Parkinsons disease, diabetes, hyperthyroidism; certain medical procedures; pregnancy; menopause; infections; obesity; spinal cord injuries; heart failure; alcohol use disorder. […] In some cases, hyperhidrosis may occur due to an underlying health condition. However, there may also be a genetic component.
  • #10 Hyperhidrosis | NHS inform
    https://www.nhsinform.scot/illnesses-and-conditions/skin-hair-and-nails/hyperhidrosis/
    Some cases of primary hyperhidrosis appear to run in families, which suggests a genetic mutation may be the cause. […] If a cause of hyperhidrosis can be identified, its known as secondary hyperhidrosis. […] Secondary hyperhidrosis can have a number of different triggers, including: pregnancy, the menopause when a womans monthly periods stop, anxiety, low blood sugar (hypoglycaemia), an overactive thyroid gland (hyperthyroidism), obesity, certain medications including some antidepressants, propranolol, pilocarpine, and bethanechol, being drunk or high on drugs, or withdrawing from alcohol or drugs if you have become addicted to them, some infections, such as tuberculosis and HIV, Parkinsons disease, disorders of the blood cells or bone marrow, such as Hodgkin lymphoma.
  • #11 Hyperhidrosis: Symptoms, Causes, Treatment
    https://www.health.com/condition/hyperhidrosis-overview
    Hyperhidrosis is the medical term for excessive sweating. The condition can begin in childhood, adolescence, or as an adult. For many people, excessive sweating runs in the family, and problems with sweat are an everyday, normal occurrence. […] Others may notice excess sweat began after taking medication or being diagnosed with a disease like diabetes. However, because hyperhidrosis can affect people physically and psychologically and drastically affect one’s confidence, treatment can improve your quality of life. […] There are two types of hyperhidrosis, primary and secondary, which are diagnosed based on the cause of excessive sweating. […] This type of hyperhidrosis typically begins in childhood or around puberty. Excessive sweating also runs in families; one study found family history in 30 to 50% of primary hyperhidrosis cases.
  • #12 Is Hyperhidrosis Genetic? | The Center for Hyperhidrosis
    https://www.hyperhidrosiscumc.com/is-hyperhidrosis-genetic/
    There have been a number of studies on the origins and causes of hyperhidrosis, however, it is not entirely clear or certain where this condition stems from directly. There is sufficient evidence that the condition is hereditary though. […] So yes, hyperhidrosis is thought to be a reflection of inherited genetic traits. So if you have a parent with hyperhidrosis, the odds are higher that you will too. Researchers even believe that hyperhidrosis is a dominant trait, increasing the chances that it will be inherited. […] Statistically speaking, it is estimated that between 35-55% of people with hyperhidrosis have at least one family member that also has the condition. Some studies even suggest that hyperhidrosis can be passed down through generations. […] This form of hyperhidrosis is influenced by genetic makeup. Symptoms typically begin in childhood or puberty and may persist throughout the persons life if untreated.
  • #13 Primary and Secondary Hyperhidrosis: Causes
    https://www.verywellhealth.com/hyperhidrosis-causes-4777757
    A common cause of secondary hyperhidrosis is extra body weight and obesity. This is likely due to body heat becoming trapped by adipose tissue, kicking off the body’s natural cooling response, and causing excessive perspiration. […] Several factors related to normal cardiovascular function overlap with hyperhidrosis. The same mechanism that triggers sweating in hyperhidrosis causes an increase in heart rate and blood pressure. […] The sympathetic nervous system, which activates the fight-or-flight response, plays a role in hyperhidrosis. The fight-or-flight response causes an increase in heart rate and blood pressure, which leads to excessive sweating. […] In primary focal hyperhidrosis, sweating usually starts during childhood, which suggests it may be genetic. […] The study authors noted primary focal hyperhidrosis appears to have an autosomal dominant pattern, meaning only one copy of the gene for the disease is required for it to manifest.
  • #14 Why am I sweating so much? – Melbourne Skin & Dermatology Clinic
    https://dermatology.melbourne/why-am-i-sweating-so-much/
    If you are self-conscious about how much you sweat, you could be suffering from a condition called hyperhidrosis. […] There are two general kinds of hyperhidrosis. Usually, it is easy to differentiate the two based on onset of the disease, family history, and symmetry of affected areas, but in some cases, further tests may need to be done to confirm the diagnosis. […] Primary hyperhidrosis can run in families. Though the exact gene that controls this has not been identified, it appears to be autosomally inherited with incomplete penetrance. […] This condition usually appears in childhood or puberty, and can continue into adulthood. […] Primary hyperhidrosis can be focal (meaning only in one area such as the armpits) or generalised (head and trunk). […] Secondary hyperhidrosis can be caused by hormonal imbalances, neurological or endocrine diseases, or certain types of drugs.
  • #15 Hyperhidrosis – Dermatologic Disorders – Merck Manual Professional Edition
    https://www.merckmanuals.com/professional/dermatologic-disorders/sweating-disorders/hyperhidrosis
    Hyperhidrosis can be focal or generalized. […] Emotional causes are common, causing sweating on the palms, soles, axillae, and forehead at times of anxiety, excitement, anger, or fear. […] Pathologic causes include diabetic neuropathy, facial herpes zoster, cervical sympathetic ganglion invasion, central nervous system injury or disease, or parotid gland injury. […] Frey syndrome is a neurologic condition due to injury to or around the parotid glands resulting from surgery, infection, or trauma. […] Other causes of focal sweating include pretibial myxedema (shins), hypertrophic osteoarthropathy (palms), blue rubber bleb nevus syndrome, and glomus tumor (over lesions). […] Generalized sweating involves most of the body. Although most cases are idiopathic, numerous conditions can be involved. […] Although generalized sweating is usually normal, consider cancer, infection, and endocrine disorders as directed by patient symptoms.
  • #16 Hyperhidrosis: Causes
    https://www.aad.org/public/diseases/a-z/hyperhidrosis-causes
    Parkinsons can affect the part of the nervous system that controls sweating. Excessive sweating can worsen as Parkinsons progresses. […] Unlike primary hyperhidrosis, secondary hyperhidrosis can cause you to sweat while youre asleep. […] You may develop secondary hyperhidrosis if you have one of the following: Take medication (described above) that can cause excessive sweating or Have a medical condition (described above) that can lead to excessive sweating. […] The etiology, diagnosis, and management of hyperhidrosis: A comprehensive review: Etiology and clinical work-up.
  • #17 Generalized Hyperhidrosis – International Hyperhidrosis Society | Official Site
    https://www.sweathelp.org/about-hyperhidrosis/causes-of-secondary-hyperhidrosis/generalized-hyperhidrosis.html
    Generalized hyperhidrosis is usually secondary to an underlying medical condition or can have a physiological basis with heat, humidity, or exercise, leading to excessive sweating out of proportion to thermoregulatory needs. […] Infections, neoplasia, metabolic and endocrine disorders, high catecholamine states, drug therapy, and neurologic problems can all be associated with systemic hyperhidrosis. […] Endocrine disorders associated with hyperhidrosis include thyrotoxicosis, hyperpituitarism, diabetes mellitus, pheochromocytoma, hypoglycemia, gout, and menopause. […] Increased metabolic activity due to hyperpituitarism can lead to increased thermoregulatory sweating. […] Excessive sweating, tachycardia, and headache in a patient with hyperhidrosis should raise suspicion of pheochromocytoma and prompt measurement of catecholamine levels.
  • #18 Diaphoresis: Causes & Treatment
    https://my.clevelandclinic.org/health/diseases/24496-diaphoresis
    Diaphoresis means excessive sweating due to a secondary condition. […] Diaphoresis is the medical definition of excessive sweating due to an underlying health condition or a medication. […] Diaphoresis means abnormal sweating due to a secondary condition. Causes of diaphoresis may include: […] Menopause is one of the most common causes of diaphoresis in women. […] Diaphoresis is also a common condition during pregnancy. […] When your thyroid becomes overactive, it makes too much of a hormone called thyroxine. This is called hyperthyroidism. […] If you have diabetes, excessive sweating may be a sign of low blood sugar (hypoglycemia). […] Excessive sweating is one of the most common signs of a heart attack (myocardial infarction). […] Diaphoresis is a common symptom of substance withdrawal. […] Certain cancers and cancer treatments can cause excessive sweating. […] Severe allergic reactions to triggers such as peanuts, shellfish or bee stings can cause anaphylaxis. […] Certain prescription and over-the-counter (OTC) medications can cause side effects that include excessive sweating.
  • #19 Excessive Sweating Causes – University Health News
    https://universityhealthnews.com/daily/general-health/excessive-sweating-causes/
    The following are some of the common excessive sweating causes. Your doctor can help you determine which apply to you: Tuberculosis is mostly associated with night sweats. HIV can also cause excessive sweating. […] Neurological disorders. Parkinson’s disease may affect the autonomic nervous system, which is responsible for sweat regulation, which can cause you to either sweat too much or too little. Many times, a prescribed medication used to treat Parkinson’s can contribute to excessive sweating. […] Endocrine disturbances. Hormonal changes, pregnancy, and menopause could be to blame. The hot flashes accompanied with menopause can lead to excessive sweating. When the estrogen levels drop it can also lead to sweating. […] Hyperthyroidism. The thyroid controls metabolism within the body. It is responsible for your body’s use of energy. When the thyroid gland is overactive, it makes excessive amounts of the thyroid hormone. It causes the body’s processes to speed up, which results in nervousness, rapid heartbeat, anxiety, hand tremors, and excessive sweating.
  • #20 Excessive Sweating Causes – University Health News
    https://universityhealthnews.com/daily/general-health/excessive-sweating-causes/
    Diabetes. In some cases, diabetes can cause damage to the autonomic nervous system, including the nerves that control the sweat glands, over time. This condition is known as diabetic neuropathy. Hypoglycemia can also trigger a fight-or-flight response in the body, which can cause excessive sweating. […] Medication. Twenty-two percent of people notice excessive sweating as one of side effects of taking antidepressants. […] Anxiety. Stress hormones can cause profuse sweating due to water being eliminated through the skin instead of the kidneys, thus, preventing the need to urinate in a potentially dangerous situation. […] Heart attack. One of the symptoms of a heart attack is excessive sweating. […] Heat exhaustion. Hot weather, of course, is one of the main causes of heat exhaustion. […] Spinal cord injury. Excessive sweating can be caused by neurovascular instability syndrome.
  • #21 Hyperhidrosis Causes
    https://mobile.fpnotebook.com/Derm/Sweat/HyprhdrsCs.htm
    Hyperhidrosis Causes, Causes of Excessive Sweating […] Cholinergic Agent exposure […] Alcohol use […] Substance Abuse […] Opioid Withdrawal, Alcohol Withdrawal or other Drug Withdrawal […] Diabetes Mellitus […] Hypoglycemia […] Thyrotoxicosis or Hyperthyroidism […] Hyperpituitarism […] Pheochromocytoma […] Arnold-Chiari Malformation […] Parkinsonism […] Spinal Cord Injury […] Horner’s Syndrome […] Generalized Anxiety Disorder […] Social Anxiety […] Panic Attack […] Tuberculosis […] COPD […] Acute Respiratory Failure […] Congestive Heart Failure […] Lymphoma […] Carcinoid […] Spicy Foods […] Febrile Illness (and defervescence)
  • #22 Reddit – The heart of the internet
    https://www.reddit.com/r/Hyperhidrosis/comments/1gk2d71/what_causes_hyperhidrosis/
    Nervous system disorders: Conditions like Parkinsons disease, spinal cord injuries, or strokes may lead to excessive sweating due to nerve dysregulation. […] Heart conditions: Heart attacks or heart failure can sometimes trigger excessive sweating. […] Obesity: Higher body mass can increase sweat production as the body tries to regulate its temperature. […] Anxiety and stress: Stress activates the bodys „fight-or-flight” response, which can lead to increased sweating, particularly in people with hyperhidrosis. […] Medications that can cause increased sweating as a side effect include antidepressants, opioids, certain blood pressure drugs, and some diabetes medications.
  • #23 Focal Secondary Hyperhidrosis – International Hyperhidrosis Society | Official Site
    https://www.sweathelp.org/about-hyperhidrosis/causes-of-secondary-hyperhidrosis/focal-hyperhidrosis.html
    A variety of diseases can cause localized hyperhidrosis. Neurologic injury and dermatologic syndromes make up the majority of secondary causes of excessive focal sweat production. […] Acute spinal cord injury would be expected to lead to loss of sweating below the site of injury, but such injuries can also lead to localized areas of hyperhidrosis seen months to years after the injury. […] Central nervous system injuries such as strokes leading to hemispheric or medullary infarcts can lead to hyperhidrosis on the ipsilateral and contralateral side, respectively. […] Injury to the cranial part of the sympathetic chain by accessory cervical ribs can lead to hyperhidrosis on the face, neck, and shoulder. […] An intrathoracic tumor impinging on the sympathetic trunk or postganglionic nerves can cause hyperhidrosis by a similar mechanism.
  • #24 Focal Secondary Hyperhidrosis – International Hyperhidrosis Society | Official Site
    https://www.sweathelp.org/about-hyperhidrosis/causes-of-secondary-hyperhidrosis/focal-hyperhidrosis.html
    In reflex sympathetic dystrophy, hyperhidrosis is often seen in the affected area. […] If this area of anhidrosis is sufficiently large, compensatory hyperhidrosis can occur in innervated areas. […] Compensatory hyperhidrosis is also seen in diabetic neuropathy, after thoracic sympathectomy (ETS), and in Ross syndrome, a rare syndrome in which anhidrosis occurs in a dermatomal pattern due to focal dysfunction of the sympathetic fibers innervating sweat glands. […] It should be noted that compensatory sweating after ETS for the treatment of hyperhidrosis has been reported as potentially being as severe or more severe than the original sweating problem and may require treatment in itself. […] Conditions sometimes associated with palmoplantar hyperhidrosis include Raynauds disease, erthromelalgia, atrioventricular fistula, cold injury, rheumatoid arthritis, and some rare dermatologic syndromes. […] In one type of focal hyperhidrosis, gustatory sweating, increased perspiration occurs on the cheek or mandibular area of the face simultaneously with salivation. […] High thoracic sympathectomy and diabetic neuropathy involving nerves to the same area can also lead to this syndrome.
  • #25 Generalized Hyperhidrosis – International Hyperhidrosis Society | Official Site
    https://www.sweathelp.org/about-hyperhidrosis/causes-of-secondary-hyperhidrosis/generalized-hyperhidrosis.html
    The hot flashes of menopause can be accompanied by hyperhidrosis due to changing hormone levels. […] Acute and chronic infections and neoplasia can lead to fever followed by excessive sweating. […] Conditions associated with high sympathetic discharge can lead to excessive sweating. […] Drugs reported to cause hyperhidrosis include propanolol, physostigmine, pilocarpine, tricyclic antidepressants, fluoxetine, venlafaxine, and cyclobenzaprine, but there are more, as well. […] Familial dysautonomia, or Riley-Day syndrome, can lead to generalized hyperhidrosis. […] A syndrome of episodic hypothermia with hyperhidrosis has been described, due to episodic decreases in the hypothalamic temperature setpoint as part of diencephalic epilepsy. […] Hyperhidrosis has been seen without hyperthermia in patients with a hypothalamic stroke.
  • #26 Reddit – The heart of the internet
    https://www.reddit.com/r/Hyperhidrosis/comments/1gk2d71/what_causes_hyperhidrosis/
    Hyperhidrosis, or excessive sweating, can be caused by several factors, and its often classified into two main types based on the cause: […] The exact cause isnt fully understood, but its believed to be related to overactivity of the sympathetic nervous system, which controls sweat glands. […] This form of hyperhidrosis often runs in families, suggesting a genetic component. […] This type of hyperhidrosis is caused by an underlying medical condition or a side effect of medication. […] Common medical conditions that can cause secondary hyperhidrosis include: […] Endocrine disorders: Hyperthyroidism, diabetes, and menopause (hot flashes) can increase sweating. […] Infections: Tuberculosis and HIV are examples of infections that may cause excessive sweating, especially night sweats.
  • #27
    https://mycarpe.com/blogs/sweatopedia/diseases-and-conditions-that-cause-secondary-hyperhidrosis?srsltid=AfmBOop6AFJzcNtk9R-0cfWhoi3NF63psw0QgE2zmqgoL7SfLqIJql3W
    Menopause begins at a median age of 51 and up to 80% of women experience sweating and flushing by the time the process has ended. […] Other physiological states that can induce hyperhidrosis are obesity, excessive heat and fever. […] There are many diseases and pathologic conditions that have the potential to cause secondary hyperhidrosis. […] These are diseases and conditions that impact hormones and structures that control and secrete them. […] Here are the most common endocrine conditions that can cause hyperhidrosis: Hyperthyroidism: This is over-activation of the thyroid gland and can be a common cause of sweating. […] Diabetes: This is a very common cause of disease-related hyperhidrosis. […] Many infections have the potential to cause hyperhidrosis as a symptom, including: Acute bacterial or viral infections: These can include common illnesses that regularly circulate the population or more serious infections.
  • #28 Hyperhidrosis – causes and diagnosis | Future for Patients
    https://futureforpatients.com/en-us/disease-patterns/hyperhidrosis/
    Infectious causes e.g. tuberculosis, HIV or endocarditis infections. […] Neurological causes e.g. Parkinson’s disease, stroke, multiple sclerosis, autonomic dysfunction. […] Side effects of certain medications such as antidepressants, antipyretics, antipsychotics, antihypertensives and hormone preparations. […] Other causes e.g. cancer, alcohol abuse or stress and anxiety.
  • #29 Hyperhidrosis – Wikipedia
    https://en.wikipedia.org/wiki/Hyperhidrosis
    Hyperhidrosis can either be generalized, or localized to specific parts of the body. […] The cause of primary hyperhidrosis is unknown. […] Similarly, secondary (generalized) hyperhidrosis has many causes including certain types of cancer, disturbances of the endocrine system, infections, and medications. […] Primary (focal) hyperhidrosis has many causes. […] A variety of cancers have been associated with the development of secondary hyperhidrosis including lymphoma, pheochromocytoma, carcinoid tumors (resulting in carcinoid syndrome), and tumors within the thoracic cavity. […] Certain endocrine conditions are also known to cause secondary hyperhidrosis including diabetes mellitus (especially when blood sugars are low), acromegaly, hyperpituitarism, pheochromocytoma (tumor of the adrenal glands, present in 71% of patients) and various forms of thyroid disease.
  • #30 Hyperhidrosis: Causes, Triggers, and When to Seek Help
    https://www.atlantaliposuction.com/blog/understanding-hyperhidrosis-causes/
    Stress and anxiety are powerful catalysts for excessive sweating in individuals with hyperhidrosis. […] Certain medications are well-known to trigger secondary hyperhidrosis. Among them, antidepressants and blood pressure drugs stand out for their impact. […] Diabetes can impact the body’s autonomic nervous system. This leads to secondary hyperhidrosis for some patients. […] Thyroid disorders also play a role in hyperhidrosis. An overactive thyroid gland increases metabolism. This raises body temperature, leading to excessive sweating. […] Certain types of cancer are linked with hyperhidrosis too. Lymphoma and leukemia can trigger sweating episodes, particularly at night. […] Disorders affecting the nervous system may cause hyperhidrosis as well. These conditions disrupt normal sweat regulation by the body.
  • #31 7 Causes of Excessive Sweating – The Dermatology Group | Dermatology
    https://thedermgrouppartners.com/7-causes-of-excessive-sweating/
    Primary hyperhidrosis is a condition in which your sweat glands are activated thanks to overactive nerves. This particular condition has no known medical cause and may be the result of heredity. […] Hyperthyroidism is a condition in which your thyroids are producing too much thyroxine. Thyroxine is a hormone responsible for metabolism. When too much thyroxine floods your system, you will experience rapid heartbeat and rapid weight loss. This metabolic overdrive causes excessive sweating, increased appetite, anxiety, tremors, and more. […] Sudden excessive sweating is a very common sign of an oncoming heart attack. […] Leukemia is a type of cancer most commonly found in the bone marrow and lymphatic system. […] Excessive sweating isn’t always a sign of something dramatic or life-threatening.
  • #32
    https://mycarpe.com/blogs/sweatopedia/diseases-and-conditions-that-cause-secondary-hyperhidrosis?srsltid=AfmBOop6AFJzcNtk9R-0cfWhoi3NF63psw0QgE2zmqgoL7SfLqIJql3W
    A large variety of neurological issues, those that deal with the brain and spinal cord, can cause hyperhidrosis. […] Heart failure, due to any reason, can cause secondary hyperhidrosis as a symptom. […] There are several types of cancer that can cause hyperhidrosis to result. […] There are several other conditions that can cause secondary hyperhidrosis like gout, arsenic intoxication, alcoholism and congenital conditions that are fairly common. […] Hyperhidrosis is a medical condition categorized by excessive sweating that isnt related to temperature regulation. […] The vast majority of people will either have primary focal hyperhidrosis or secondary generalized hyperhidrosis. […] The source of this type of hyperhidrosis can also be a medication. […] Many common medications can cause hyperhidrosis as a side effect.
  • #33 Azthena logo with the word Azthena
    https://www.news-medical.net/health/Hyperhidrosis-Causes.aspx
    When the cause of the condition is clear, the condition is called secondary hyperhidrosis. The onset of secondary hyperhidrosis is often more sudden than the onset of primary hyperhidrosis and is likely to cause sweating across the whole body. This can be triggered by many underlying factors, including the following: menopause, pregnancy, anxiety, low blood sugar or hypoglycemia, hyperthyroidism, diabetes, obesity, some medications such as anti-depressants and the beta-blockers, certain infections, including HIV and tuberculosis, Parkinson’s disease, disorders of the blood cell or bone marrow including Hodgkin lymphoma.
  • #34
    https://mycarpe.com/blogs/sweatopedia/diseases-and-conditions-that-cause-secondary-hyperhidrosis?srsltid=AfmBOop6AFJzcNtk9R-0cfWhoi3NF63psw0QgE2zmqgoL7SfLqIJql3W
    There are two types main types of hyperhidrosis, primary and secondary, of the two only 7% of the people suffering from hyperhidrosis have the secondary type. […] Secondary generalized hyperhidrosis is a condition in which a person has excessive sweating due to an underlying issue. […] The onset of secondary hyperhidrosis usually occurs after the age of 25 and it has a specific cause. These causes can be broken down into three main groups: drug induced, physiologic or pathologic. […] The most common cause of secondary hyperhidrosis are medicines and the side effects they cause. […] Women are often subjected to secondary hyperhidrosis resulting from normal hormonal changes they experience over a lifetime. […] During pregnancy several factors can cause a woman to sweat more than normal including increased blood volume, hormonal changes and extra weight.
  • #35 Hyperhidrosis: Background, Pathophysiology, Etiology
    https://emedicine.medscape.com/article/1073359-overview
    Hyperhidrosis may be idiopathic or secondary to other diseases, metabolic disorders, febrile illnesses, or medication use. […] Generalized hyperhidrosis may be secondary to numerous conditions including the following: […] Medications: Use of medications may affect one or more components of human thermoregulation and induce hyperhidrosis. Agents such as propranolol, physostigmine, pilocarpine, tricyclic antidepressants, and serotonin reuptake inhibitors have been implicated. […] Localized unilateral or segmental hyperhidrosis is rare and of unknown origin. […] Localized hyperhidrosis may also be associated with the following: […] Eccrine angiomatous hamartoma: This is a rare, benign malformation characterized by both eccrine and vascular components. […] Spinal cord tumors: Rarely, hyperhidrosis may be an initial symptom.
  • #36 Drug-induced hyperhidrosis
    https://dermnetnz.org/topics/drug-induced-hyperhidrosis
    Hyperhidrosis can be primary, which happens early in life, or secondary, which is caused by systemic or neurological diseases, or as a side effect of medications. […] Drug-induced hyperhidrosis is the most common cause of secondary hyperhidrosis. Drugs can act on the hypothalamus or at spinal thermoregulatory centres, at sympathetic ganglia or at the eccrine-neuroeffector junction. […] It results from the release of acetylcholine by medications that block the action of acetylcholinesterase, an enzyme that breaks down the neurotransmitter. […] Acetylcholine exerts its effect via receptors found on sweat glands. Due to impaired negative feedback to the hypothalamus, acetylcholine causes the body to sweat more than is needed for core temperature to reach homeostasis. […] Other factors that can contribute to increased sweating include a family history of increased sweating, and underlying medical conditions such as obesity, diabetes, hyperthyroidism, menopause, or cancer.
  • #37 Drug-induced hyperhidrosis
    https://dermnetnz.org/topics/drug-induced-hyperhidrosis
    Different classes of medications can influence the sweating response by acting centrally in the brain and the peripheral nervous system. […] Medications used to treat psychiatric conditions that can cause hyperhidrosis include: Selective serotonin reuptake inhibitors (SSRIs), such as citalopram; Tricyclic antidepressants, such as amitriptyline; Antipsychotics, such as haloperidol and clozapine. […] Medications used to treat dementia or Parkinson disease include: Acetylcholinesterase inhibitors, such as donepezil or benztropine. These increase sweating through direct stimulation of receptors in sweat glands. […] Pain relief medications that can cause hyperhidrosis include: Opioids, such as morphine, oxycodone, fentanyl, and tramadol; Non-steroidal anti-inflammatory medications (NSAIDs), such as celecoxib and naproxen.
  • #38 Drug-induced hyperhidrosis
    https://dermnetnz.org/topics/drug-induced-hyperhidrosis
    Antimicrobial medications and antibiotics that can cause hyperhidrosis include: Cephalosporins (eg, ceftriaxone or cefuroxime); Quinolone antibiotics (eg, ciprofloxacin); Antivirals (aciclovir or ribavirin). […] Medications that can affect endocrine function and thus cause hyperhidrosis can include: Systemic corticosteroids; Thyroid medications; Diabetic medications such as glipizide and insulin. […] Withdrawal from non-prescription drugs such as alcohol and caffeine can also cause generalised hyperhidrosis. […] Drug-induced hyperhidrosis is diagnosed clinically. Other causes of secondary hyperhidrosis should be excluded, such as an underlying infection, malignancy, neurological, or endocrine conditions. […] A temporal relationship between initiation of a certain medication and onset of symptoms with no other apparent cause of secondary hyperhidrosis is suggestive of drug-induced hyperhidrosis. […] When suspicious of drug-induced hyperhidrosis, the possible culprit medication should be stopped completely as a trial. […] Drug-induced hyperhidrosis resolves when the causative medication is stopped.
  • #39
    https://mycarpe.com/blogs/sweatopedia/diseases-and-conditions-that-cause-secondary-hyperhidrosis?srsltid=AfmBOop6AFJzcNtk9R-0cfWhoi3NF63psw0QgE2zmqgoL7SfLqIJql3W
    Doctors dont truly understand what causes primary focal hyperhidrosis yet. […] Many diseases and medical conditions can cause hyperhidrosis. […] Here are some of the more common conditions that may be causing the hyperhidrosis you have developed as an adult: A febrile illness, Menopause, Hyperthyroidism, Heart failure, Diabetes, Frostbite, Alcoholism, Gout, Lymphoma and some other cancers and tumors, Obesity, Pregnancy, Parkinsons disease, Rheumatoid arthritis, Stroke. […] There are also several types of common medications that cause hyperhidrosis as a side effect. […] If you think you might have secondary generalized hyperhidrosis it is very important that you speak to a doctor. […] The excessive sweating associated with menopause is actually considered to be a form of secondary hyperhidrosis and it can be treated.
  • #40 Excessive face and head sweating: Causes and more
    https://www.medicalnewstoday.com/articles/excessive-face-and-head-sweating
    Secondary hyperhidrosis has many potential causes. They include: infections, hormonal shifts during puberty, menopause, or after pregnancy, diabetes, overactive thyroid gland (hyperthyroidism), low blood sugar (hyperglycemia), obesity, gout, certain medications such as certain antidepressants, propranolol, pilocarpine, and bethanechol, Parkinson’s disease, drug or alcohol use, withdrawal from drugs or alcohol, head trauma or brain tumors, blood cell or bone marrow disorders, such as Hodgkin’s lymphoma, diseases that impact the sympathetic nerves, certain rare inherited conditions. […] Sometimes, treating the underlying cause will reduce or stop secondary hyperhidrosis.
  • #41 What is Hyperhidrosis: Causes, Symptoms, Precautions and Treatment
    https://www.apollohospitals.com/diseases-and-conditions/hyperhidrosis-causes-symptoms-treatment-and-precautions
    Hyperhidrosis is a condition that leads to excessive sweating that is not associated with exercising or heat. […] There are two types of hyperhidrosis conditions, primary and secondary. While the causes of the former are not yet known and often attributed to genes, the underlying causes of the latter may include thyroid, diabetes, and heart attack. […] Primary focal Hyperhidrosis does not occur due to any significant underlying disease. A hereditary component might be responsible for this condition. This type of Hyperhidrosis occurs due to the overactivity of nerves that signal your sweat glands. […] Secondary Hyperhidrosis occurs when there is an underlying medical condition. It is uncommon and more likely to affect your entire body. The medical conditions are as follows: Diabetes, Low blood sugar (Hypoglycaemia), Menopausal hot flashes, Some types of cancer, Thyroid problems, Heart attack, Disorders of the nervous system.
  • #42 Hyperhidrosis Clinical Presentation: History, Physical Examination, Complications
    https://emedicine.medscape.com/article/1073359-clinical
    Diagnostic criteria favoring primary hyperhidrosis include excessive sweating of 6 months or more in duration, with 4 or more of the following: primarily involving eccrine-dense (axillae/palms/soles/craniofacial) sites; bilateral and symmetric; absent nocturnally; episodes at least weekly; onset at age 25 years or younger; positive family history; and impairment of daily activities.
  • #43 Primary focal hyperhidrosis – UpToDate
    https://www.uptodate.com/contents/primary-focal-hyperhidrosis
    Hyperhidrosis (excessive sweating) is a common condition rarely due to significant underlying pathology that may have serious social, emotional, and professional consequences. […] Hyperhidrosis is the secretion of sweat in amounts greater than physiologically needed for thermoregulation. It is most commonly a chronic idiopathic (primary) condition; however, secondary medical conditions or medications should be excluded. […] Idiopathic hyperhidrosis localized to certain areas of the body is called primary focal hyperhidrosis. Primary focal hyperhidrosis usually affects the axillae, palms, and soles. The condition may also affect other sites, such as the face, scalp, inguinal, and inframammary areas. […] A consensus panel suggested the following diagnostic criteria for primary focal hyperhidrosis: Focal, visible, excessive sweating of at least six months duration without apparent cause.
  • #44 Hyperhidrosis Clinical Presentation: History, Physical Examination, Complications
    https://emedicine.medscape.com/article/1073359-clinical
    Essential hyperhidrosis is a dermatologic and neurologic disorder characterized by excessive sweating of the eccrine sweat glands. […] Hyperhidrosis beginning later in life should prompt a search for secondary causes such as systemic diseases, adverse effects of medication use, or metabolic disorders. […] Excessive sweating may be primary (idiopathic) or secondary to medication or disease. Secondary causes include endocrine diseases such as diabetes mellitus, hyperthyroidism, and hyperpituitarism. In one series, one third of cases were neurologic in origin, including peripheral nerve injury, Parkinson disease, reflex sympathetic dystrophy, spinal injury, and Arnold-Chiari malformation. Additional causes to consider include pheochromocytoma, respiratory disease, and psychiatric disease.
  • #45 Hyperhidrosis – StatPearls – NCBI Bookshelf
    https://www.ncbi.nlm.nih.gov/books/NBK459227/
    Hyperhidrosis can be categorized as either primary or secondary. This distinction is important because treatment and management may significantly differ between the two groups. The etiology of primary hyperhidrosis remains unknown despite multiple literature reviews. Genetic factors are believed to play a role in excessive neural stimulation, although this is poorly understood. […] Secondary causes are usually easier to identify because they are associated with medications such as dopamine agonists, selective serotonin reuptake inhibitors (SSRIs), antipsychotics, and insulin; systemic disorders such as diabetes mellitus, hyperthyroidism, Parkinson disease, and other neurologic disorders; and tumors such as pheochromocytoma and lymphoma. […] Almost any febrile illness can cause hyperhidrosis. Chronic excessive alcohol consumption and tuberculosis are also associated with hyperhidrosis. Developing segmental or localized hyperhidrosis is rare. The condition can present on some adults’ forehead, axilla, palm, feet, or forearm. Some postmenopausal women develop moderate to severe hyperhidrosis around their face and scalp. Unilateral hyperhidrosis tends to be more common on the right side of the face or arm, with anhidrosis on the left side.