Materiały źródłowe

• #1 Lichen planus – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/lichen-planus/diagnosis-treatment/drc-20351383

  If you have no pain or discomfort, you may not need any treatment. Lichen planus on the skin often clears up on its own in months to years. […] Medicines and other treatments might help relieve itching, ease pain and speed healing. Talk with your health care provider to weigh the pros and cons of treatment options. You may need more than one approach to control your symptoms. […] If the disease affects your mucous membranes and nails, it tends to be harder to treat. Even if treatment works, the symptoms may return. You’ll likely need to visit your health care provider for follow-up care at least once a year. […] Often, the first choice for treatment of lichen planus of the skin is a prescription corticosteroid cream or ointment. This may help ease pain, swelling and inflammation. […] If a topical corticosteroid doesn’t help and your condition is severe or widespread, your health care provider might suggest corticosteroid pills or injections.

• #2 Lichen Planus: What It Is, Causes, Types & Treatments

  https://my.clevelandclinic.org/health/diseases/17723-lichen-planus

  There isnt a cure for lichen planus. If you have lichen planus on your skin, in most cases, it goes away without treatment in as little as a few months to several years. […] The following treatments may help relieve your symptoms: […] Corticosteroid creams or ointments. Your healthcare provider may prescribe corticosteroid creams or ointments to reduce inflammation. […] Antihistamines. Antihistamines are a class of drugs commonly used to treat allergy symptoms, including itchy skin. […] Phototherapy. Phototherapy uses ultraviolet light, usually ultraviolet B (UVB), from special lamps. The ultraviolet light waves found in sunlight can help certain skin disorders, including lichen planus. […] Immunosuppressants. Medications that lower your immune system such as oral corticosteroids, mycophenolate mofetil, azathioprine or cyclosporine can be helpful.

• #3 Lichen planus | NHS inform

  https://www.nhsinform.scot/illnesses-and-conditions/skin-hair-and-nails/lichen-planus/

  Theres no single treatment that can cure lichen planus completely. However, treatments are available to help manage the symptoms and make living with it easier. For example, steroid creams or ointments are often used to help relieve the itch and control the rash. […] Most cases of lichen planus of the skin clear up on their own within 6 to 9 months. The rash rarely lasts longer than 18 months. However, oral lichen planus and lichen planus that affects the genital area may be more persistent. […] Theres no cure for lichen planus, so treatments aim to ease the symptoms and clear the rash. Mild lichen planus doesnt require treatment. […] Corticosteroid creams and ointments contain corticosteroids (artificial hormones) and are used to treat inflammatory skin conditions. They are often referred to as topical corticosteroids.

• #4 Lichen Planus – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK526126/

  Lichen planus is an inflammatory condition of unknown etiology affecting the skin and mucous membranes. […] The natural course of lichen planus varies widely. Most patients with cutaneous lesions experience spontaneous resolution within 1 to 2 years of onset. However, recurrences are common, and residual skin hyperpigmentation often persists. […] This activity for healthcare professionals describes the epidemiology, genetics, diagnostic approaches, treatment options, and management strategies for cutaneous and oral forms of the disease. […] Treatment-induced remission is typically followed by relapse. Thus, asymptomatic oral lichen planus should not be treated due to the high burden of treatment-related adverse effects. […] Cutaneous lichen planus typically resolves spontaneously within 1 to 2 years; therefore, treatment is aimed at reducing pruritus and allowing time for resolution. For limited lichen planus, the recommended first-line treatment is superpotent topical steroids (clobetasol 0.05%) twice daily for 2 to 4 weeks.

• #5 Lichen planus: Diagnosis and treatment

  https://www.aad.org/public/diseases/a-z/lichen-planus-treatment

  Your dermatologist can often diagnose lichen planus by: […] If the diagnosis is lichen planus, your dermatologist will decide whether you need treatment. […] Not everyone needs treatment. Your dermatologist may recommend treatment to relieve symptoms like itch or prevent the condition from worsening. […] When treatment is needed to relieve symptoms, such as itch or pain, or to help the skin clear, a treatment plan for the skin may include one or more of the following: […] Corticosteroid cream or ointment: This medication can reduce swelling, color changes, and itch. It may be used alone or prescribed along with another treatment. […] Tacrolimus ointment or pimecrolimus cream: These medications help reduce bumps and discomfort caused by lichen planus. […] Antihistamine pills: This medication can relieve the itch. Your dermatologist can choose an appropriate antihistamine and adjust the dosage to fit your needs.

• #6 Diagnosis and Treatment of Lichen Planus | AAFP

  https://www.aafp.org/pubs/afp/issues/2011/0701/p53.html

  High-potency topical corticosteroids are first-line therapy for all forms of lichen planus, including cutaneous, genital, and mucosal erosive lesions. […] In addition to clobetasol, topical tacrolimus appears to be an effective treatment for vulvovaginal lichen planus. […] Systemic corticosteroids should be considered for severe, widespread lichen planus involving oral, cutaneous, or genital sites. […] Referral to a dermatologist for systemic therapy with acitretin (an expensive and toxic oral retinoid) or an oral immunosuppressant should be considered for patients with severe lichen planus that does not respond to topical treatment. […] High-potency topical corticosteroids should be first-line treatments for all forms of lichen planus. […] Oral corticosteroids (prednisone) should be used for severe, widespread lichen planus (tapered course, 30 to 60 mg per day starting dose).

• #7 Lichen planus: Symptoms, Types, and Treatment with Images — DermNet

  https://dermnetnz.org/topics/lichen-planus

  What is the treatment for lichen planus? […] General measures include avoiding soaps and shower gels that will exacerbate scaling, using emollients regularly, and sedating antihistamines may help troublesome nocturnal itch. […] Specific treatment is not always necessary as cutaneous LP can be self-limiting and treatment goals are to manage pruritus. Local treatments for the symptomatic cutaneous or mucosal disease are potent topical corticosteroids (including steroid impregnated tape), topical calcineurin inhibitors, tacrolimus ointment, and pimecrolimus cream, topical retinoids, and intralesional steroid injections. […] Systemic treatment for widespread lichen planus or severe local disease often includes a 1- to 3-month course of systemic steroids (eg, prednisone), while commencing another agent from the following list: Acitretin, Hydroxychloroquine, Methotrexate, Azathioprine, Mycophenolate mofetil, and Phototherapy.

• #8 Lichen Planus – Dermatologic Disorders – Merck Manual Professional Edition

  https://www.merckmanuals.com/professional/dermatologic-disorders/psoriasis-and-scaling-diseases/lichen-planus

  Treatment generally requires topical or intralesional corticosteroids. Severe cases may require phototherapy or systemic corticosteroids, retinoids, or immunosuppressants. […] Most cases of lichen planus on the trunk or extremities can be treated with topical treatments. Topical corticosteroids are first-line treatment for most cases of localized disease. High-potency ointments or creams (eg, clobetasol, fluocinonide) may be used on the thicker lesions on the extremities; lower-potency corticosteroids (eg, hydrocortisone, desonide) may be used on the face, groin, and axillae. […] Intralesional corticosteroids (triamcinolone acetonide solution diluted with saline to 5 to 10 mg/mL) can be used every 4 weeks for hyperkeratotic plaques, scalp lesions, and lesions resistant to other therapies.

• #9 Lichen Planus – Dermatologic Disorders – Merck Manual Professional Edition

  https://www.merckmanuals.com/professional/dermatologic-disorders/psoriasis-and-scaling-diseases/lichen-planus

  Local therapy is impractical for generalized lichen planus; thus, an oral medication or phototherapy is used. Oral corticosteroids (eg, prednisone 20 mg once a day for 2 to 6 weeks followed by a taper) may be used for severe cases. […] Oral retinoids (eg, acitretin) are indicated for otherwise recalcitrant cases. Light therapy using psoralen plus ultraviolet A (PUVA) or narrowband ultraviolet B (NBUVB) is an alternative to oral therapies, especially if they have failed or are contraindicated. […] Treatment of oral lichen planus differs slightly from the treatment of other affected areas. Viscous lidocaine may help relieve symptoms of erosive ulcers; because inflamed mucous membranes can absorb high amounts, dose should not exceed 200 mg (eg, 10 mL of a 2% solution) or 4 mg/kg (in children) 4 times a day. Tacrolimus 0.1% ointment applied twice daily may induce lasting remission, but the data are limited. […] Other treatment options include topical (in an adhesive base), intralesional, and systemic corticosteroids. Erosive oral lichen planus may respond to oral dapsone, hydroxychloroquine, or cyclosporine.

• #10 Different Treatment Modalities of Oral Lichen Planus—A Narrative Review

  https://www.mdpi.com/2304-6767/11/1/26

  Administering systemic corticosteroids requires caution due to a number of serious side effects when administered over a long period of time and in large doses. […] The purpose of this paper was to present current therapeutic options in the treatment of OLP and gain insight into their effectiveness and safety in treating OLP lesions. […] Potent topical corticosteroids have been accepted as first-line treatment; however, no solid scientific evidence supports this fact. […] The reasoning behind this is that the authors note the small number of included studies and participants. […] In addition to corticosteroids, numerous studies in the literature have examined the effectiveness of various drugs and preparations in the treatment of OLP. […] Systemic corticosteroids are considered the most effective in treating patients with diffuse erosive OLP, in those cases where the disease does not respond to topical steroid preparations, and in patients with the mucocutaneous form of the disease.

• #11 Lichen planus – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/lichen-planus/diagnosis-treatment/drc-20351383

  Other oral medicines used for lichen planus are the antimalarial hydroxychloroquine (Plaquenil) and the antibiotic metronidazole (Flagyl, others). […] For more-severe symptoms, you may need prescription medicine that changes your body’s immune response. The following drugs have been used with some success but further study is needed: cyclosporine (Sandimmune), Azathioprine (Azasan), methotrexate (Trexall), mycophenolate (Cellcept), sulfasalazine, thalidomide (Thalomid). […] An antihistamine medicine taken by mouth might ease the itchy skin caused by lichen planus. […] Light therapy may help clear up lichen planus affecting the skin. This approach is also called phototherapy. One method involves exposing the affected skin to ultraviolet B light 2 to 3 times a week for several weeks. […] Your health care provider might prescribe a retinoid medicine taken by mouth or applied to the skin. One example is acitretin. […] If your health care provider thinks that your lichen planus is related to an infection, allergies, a medicine you take or some other trigger, you might need other treatment or tests to address that.

• #12 Lichen Planus Treatment & Management: Medical Care

  https://emedicine.medscape.com/article/1123213-treatment

  Newer topical calcineurin inhibitors (eg, tacrolimus and pimecrolimus) have replaced topical cyclosporine for the treatment of LP. Other options include oral or topical retinoids. Even with these effective treatments, relapses are common. […] Patients with widespread LP may respond to narrowband or broadband ultraviolet (UV)-B therapy. […] Psoralen with UV-A (PUVA) therapy for 8 weeks has been reported to be effective. […] Apremilast may be an effective treatment for LP, but double-blind controlled trials are lacking.

• #13 Generalized Lichen Planus Treated With Narrowband UV-B Phototherapy: Results From 10 Patients and a Review of the Literature | Actas Dermo-Sifiliográficas

  https://www.actasdermo.org/en-generalized-lichen-planus-treated-with-articulo-S1578219019301623

  Generalized lichen planus (GLP) can be difficult to treat. One alternative for patients who do not respond to common topical and systemic treatments, such as corticosteroids and oral antihistamines, is phototherapy. Narrowband UV-B phototherapy offers several advantages and is currently the main treatment modality. […] The only published guidelines for GLP treatment consider phototherapy (narrowband ultraviolet B [UV-B] and psoralen and ultraviolet A [PUVA] therapies) the treatment of choice for patients that do not respond to topical treatments. […] Narrowband UV-B phototherapy is a widely used alternative to systemic treatments in GLP, but there are very few reports of its results in the literature. […] Narrowband UV-B phototherapy offers certain advantages over PUVA phototherapy: patients do not require pretreatment with oxsoralen, which is sometimes contraindicated, nor do they remain photosensitized for several hours after treatment.

• #14 Diagnosis and Treatment of Lichen Planus | AAFP

  https://www.aafp.org/pubs/afp/issues/2011/0701/p53.html

  For genital lichen planus lesions, triamcinolone ointment (Triderm) is a good first-line agent. […] Topical tacrolimus (Protopic) and clobetasol (Temovate) appear to be effective treatments for vulvovaginal erosive lichen planus. […] Aloe vera gel has been deemed a safe and effective treatment for patients with vulvar lichen planus. […] Topical corticosteroids are first-line therapy for mucosal erosive lichen planus. […] Topical calcineurin inhibitors, such as tacrolimus and pimecrolimus (Elidel), are second-line therapies for oral lichen planus. […] A randomized controlled trial revealed that pimecrolimus 1% cream effectively treats erosive oral lichen planus with long-lasting therapeutic effects. […] If topical corticosteroids are ineffective, carbon-dioxide laser evaporation can lead to long-term remission of symptoms, and may be appropriate as first-line therapy in patients with painful oral lichen planus.

• #15 Lichen Planus: Symptoms and Treatment | The Skin Surgery Center

  https://www.skinsurgerycenter.net/conditions/lichen-planus

  PUVA Therapy (Light Therapy): This involves exposure to ultraviolet A (UVA) light after taking a light-sensitizing medication (psoralen). It can be effective in managing lichen planus symptoms. […] Retinoic Acid: Topical or oral retinoids, such as retinoic acid, may be recommended to promote skin cell turnover and reduce inflammation. […] Tacrolimus Ointment or Pimecrolimus Cream: These are calcineurin inhibitors that can be applied topically. They are an alternative to corticosteroids, particularly in sensitive areas. […] It’s important to note that treatment plans may vary based on the type and severity of lichen planus, as well as individual patient factors. Schedule an appointment with one of our skin experts to determine your treatment plan for Lichen Planus.

• #16 Lichen Planus – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK526126/

  If no change is observed, second-line therapy should be considered. Second-line therapy may include metronidazole (500 mg twice daily for 3 to 8 weeks), sulfasalazine (500 mg twice daily increased in 500 mg increments every 3 days until 2.5 g daily is reached, for 3 to 6 weeks), isotretinoin (10 mg twice daily for 2 months), acitretin (30 mg daily for 8 weeks), psoralen and ultraviolet A, ultraviolet B, topical calcineurin inhibitors, or methotrexate (15 mg per week for adults, 0.25 mg/kg per week for children). […] Oral lichen planus may spontaneously resolve within 5 years, but many cases are chronic and do not resolve. Treatment-induced remission is typically followed by relapse. Thus, asymptomatic oral lichen planus should not be treated due to the high burden of adverse effects associated with treatment. […] Consideration of drug-induced lichen planus must always be explored before starting therapy. Withdrawal of the suspected drug leading to the gradual disappearance of lesions confirms the diagnosis, although it may take some time for lesions to resolve fully.

• #17 Lichen Planus: What It Is, Causes, Types & Treatments

  https://my.clevelandclinic.org/health/diseases/17723-lichen-planus

  Retinoids (vitamin A derivatives). Retinoids are a pill or ointment that help your body produce more collagen and blood vessels, which can help your rash. Retinoids may cause birth defects, so its a good idea to check with your healthcare provider if youre pregnant or planning to become pregnant. […] If you have lichen planus in your mouth, in most cases, it goes away within five years. If you experience irritation or sores, you can help alleviate your symptoms by: […] Practicing good oral hygiene. Regularly brush and floss your teeth, and get your teeth professionally cleaned by your dentist at least twice a year. […] Minimize injuries (trauma). Injuries to your mouth can increase the severity of your sores, as well as how often flare-ups occur. Gently brush your teeth, put dental wax around braces or orthodontic wires and consider removing any piercings that bump or rub against the inside of your mouth.

• #18 Oral lichen planus – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/oral-lichen-planus/diagnosis-treatment/drc-20350874

  Oral lichen planus is a lifelong condition. Mild forms may go away on their own but flare up later. Because there is no cure, treatment focuses on healing and easing pain or other symptoms that bother you. Your healthcare professional watches your condition to find the best treatment or to stop treatment as needed. […] If you have no pain or other discomfort, and you only have white, lacy signs of oral lichen planus in your mouth, you may not need any treatment. For more-severe symptoms, you may need one or more of the options below. […] Treatments such as numbing agents applied to the skin can give relief for a short time in areas that are very painful. […] Medicines called corticosteroids may lower inflammation related to oral lichen planus. Your healthcare professional may recommend one of these forms:

• #19 Oral Lichen Planus: Symptoms, Causes & Treatment

  https://my.clevelandclinic.org/health/diseases/17875-oral-lichen-planus

  Oral lichen planus isnt dangerous. Its not contagious, so you cant spread it to others. But it can cause abnormal tissue (lesions) to form in your mouth. It can make your mouth hurt. […] This is why you should see a dental care provider if you notice signs of this disease. Theres no cure for oral lichen planus, but treatments can provide relief. […] Treatment for OLP focuses on reducing symptoms and preventing flare-ups. This means you may not need treatment if you dont have symptoms that are bothering you. […] Treatment usually involves a mix of medications and lifestyle changes to avoid triggers. […] If you have symptoms, your healthcare provider will likely recommend medications. Some may calm your immune system so theres less inflammation. Others relieve pain. Common oral lichen planus treatments include:

• #20 Lichen planus: Diagnosis and treatment

  https://www.aad.org/public/diseases/a-z/lichen-planus-treatment

  Corticosteroid: This medication is prescribed to reduce inflammation, which can relieve symptoms and prevent further hair loss. […] Hydroxychloroquine (pills) and other medication that calms the immune system: Calming the immune system effectively treats lichen planopilaris for some people. […] If oral lichen planus is causing a burning sensation in your mouth, painful ulcers, or rawness, treatment is recommended. […] A treatment plan typically includes: […] Corticosteroid gel or ointment: This medication can lessen symptoms and help clear the disease in your mouth. […] Medication that works throughout the body: If you have symptoms, such as painful sores or erosions in your mouth, you may need an oral (take by mouth) corticosteroid like prednisone or an oral retinoid like isotretinoin.

• #21 Lichen planus – A refractory autoimmune disorder – IJCED

  https://www.ijced.org/html-article/18573

  Oral LP may spontaneously resolve within 5 years, but many cases are chronic which never resolve. Asymptomatic oral LP usually not treated as the side-effects with treatment would overweight the benefits. Remission following treatment is typically followed by relapse. Thus, the ultimate goal for treatment of symptomatic oral LP is to heal erosive lesions to reduce pain and allow normal food intake. Avoiding spicy or acidic foods as well as alcohol and tobacco, is to be executed. First-line treatment is topical steroids, lidocaine I/L steroids, retinoid gel, topical immunomodulators until remission. No improvement after 6 weeks should prompt escalation of therapy. Second-line treatment is cyclosporine mouth wash, extracorporeal photochemotherapy, photodynamic therapy. Third-line treatment may include cyclosporine, azathioprine, mycophenolate mofetil, or methotrexate.

• #22 Lichen planus – A refractory autoimmune disorder – IJCED

  https://www.ijced.org/html-article/18573

  Pimecrolimus 1% cream seems to be an effective and well-tolerated treatment for oral erosive lichen planus. […] Cyclosporine can be used either in the form of mouthwashes or in the form of an adhesive base. […] Levamisole seems to have a preferential effect on T helper-1 cells with subsequent upregulation of interleukin-2, interleukin-12 and interferon-. […] Mycophenolate mofetil (MMF) is an immunosuppressive drug that specifically and reversibly inhibits the proliferation of activated T cells. […] Azathioprine has been shown to be an effective steroid sparing treatment for generalized lichen planus. […] Dapsone is effective for erosive lichen planus. […] Surgical excision of OLP is considered an effective treatment for isolated plaques or nonhealing erosions.

• #23 Lichen planus: Diagnosis and treatment

  https://www.aad.org/public/diseases/a-z/lichen-planus-treatment

  To prevent nail disease from worsening, your dermatologist may include one or more of the following in your treatment plan. […] Corticosteroid injections: This medication can prevent the disease from worsening and allow you to keep your existing nails. […] Prednisone (pill): This medication can decrease symptoms like swelling and slow an overactive immune system. […] Acitretin: This medication is an oral (take by mouth) retinoid that can clear or markedly reduce lichen planus on your skin. […] When lichen planus affects the genitals, it can cause discomfort, itch, pain, or scarring. […] Treatment can prevent the condition from progressing and reduce symptoms. […] Moisturizers and barrier repair creams: These can soothe the discomfort, reduce dryness, and create a protective barrier that can help with healing.

• #24 Lichen planus: Diagnosis and treatment

  https://www.aad.org/public/diseases/a-z/lichen-planus-treatment

  Corticosteroid cream or ointment: This medication can reduce inflammation, which can reduce symptoms. […] Combination of medication you apply to the genitals and medication that works throughout the body to calm the immune system: If the lichen planus is widespread or medication applied to the area is not working, your dermatologist may create a treatment plan that uses different medications to get the lichen planus under control.

• #25 Lichen planus: Diagnosis and treatment

  https://www.aad.org/public/diseases/a-z/lichen-planus-treatment

  Phototherapy: This treatment uses ultraviolet (UV) light to help clear your skin. […] Acitretin: This medication is an oral (take by mouth) retinoid that can clear or markedly reduce widespread rashes, bumps, and other signs on your skin. […] Corticosteroid (injections or pills): If the lichen planus causes thick plaques, lasts a long time, or has caused many bumps or painful sores, your dermatologist might recommend shots. […] Oral (take by mouth) medication that calms your immune system: Some of these medications have been reported to clear or reduce widespread lichen planus on the skin. […] Treatment can prevent loss of hair on the scalp, eyebrows, or both. […] Treatment can also alleviate symptoms like itching, burning, and stinging. […] A treatment plan for lichen planopilaris may include:

• #26 Lichen planus – BAD Patient Hub

  https://www.skinhealthinfo.org.uk/condition/lichen-planus/

  Lichen planus of the hair (lichen planopilaris). This carries the risk of permanent hair loss (scarring alopecia). Treatments include topical potent or ultrapotent steroids, steroid injections, and medicines such as hydroxychloroquine. […] Lichen planus of the nails. Nail disease can be slow, or rapidly progressive, and may cause permanent damage. […] Lichen planus of the vulva and vagina. This can be particularly stubborn. Initial treatment is with potent and super potent topical steroids and maintaining good skin care of the area. […] Lichen planus of the penis. In most cases, lichen planus without symptoms does not require treatment. If symptoms are present, potent and/or super potent topical steroids are used. […] Please note, there are no specific medicines directly developed to treat lichen planus. The use of medicines described above are outside of their product license.

• #27 Azthena logo with the word Azthena

  https://www.news-medical.net/news/20250203/New-targeted-therapy-could-bring-relief-to-people-with-lichen-planus.aspx

  Mayo Clinic researchers have identified a targeted therapy that could bring relief to people living with lichen planus, a chronic inflammatory skin condition of the skin, hair, nails, mouth and genitals. […] The researchers then used baricitinib, a medication that selectively blocks the specific inflammatory pathways of lichen planus, to treat patients in the study. […] The patients with treatment-refractory disease experienced early and sustained clinical response to the treatment, resulting in an 83% improvement in symptom responsiveness within 16 weeks of treatment, a marked improvement over baseline. […] This research provides valuable insights into the pathophysiology of lichen planus and demonstrates the potential of baricitinib as a promising treatment option.

• #28

  https://link.springer.com/article/10.1007/s40257-024-00878-9

  Lichen planus (LP), an idiopathic, multifaceted chronic inflammatory disease with a heterogeneous clinical presentation, affects approximately 0.51% of the population. […] Several treatment strategies have been attempted, though most of them have not been adopted in clinical practice because of suboptimal benefit-to-risk ratios or lack of evidence. More recent studies toward pathogenesis-driven treatments have identified Janus kinase inhibitors such as tofacitinib, phosphodiesterase-4 inhibitors such as apremilast, and biologics targeting the interleukin-23/interleukin-17 pathway as novel therapeutic options, resulting in a dramatic change of the treatment landscape of LP. […] This contemporary review focuses on the diagnosis and management of LP, and places emphasis on more recently described targeted treatment options.

• #29 American Academy of Dermatology Meeting

  https://www.healio.com/news/dermatology/20230321/patients-with-lichen-planus-show-improvement-with-baracitinib

  All patients treated with baracitinib for lichen planus had a response at week 12. […] After 1 week of treatment, 37.5% of patients had a physician global assessment response of clear or almost clear. […] A first-in-human study found patients with lichen planus treated with the Janus kinase inhibitor baracitinib achieved almost total improvement. […] Researchers conducted an open-label, single-arm trial in 12 patients with LP who were treated with baracitinib twice daily for 16 weeks. […] After 1 week of treatment, 37.5% of patients were responsive to baracitinib, with 100% of patients showing a PGA response of clear or almost clear at week 12. […] At week 16, 90.9% of patients were responsive, which increased to 100% at week 20 after 4 weeks off therapy. […] Targeted therapy with baracitinib in LP led to a rapid and sustained response in cutaneous LP, Hwang said. Based on the promising results of this open-label, single-arm trial, future randomized controlled trials of baracitinib are warranted.

• #30 Managing Lichen Planus – The Dermatology Digest

  https://thedermdigest.com/managing-lichen-planus/

  A small study showed that aprimilast can help to manage moderate-severe lichen planus, said Dr. Friedman. […] Interleukin (IL)-17 biologics are even more promising, said Dr. Friedman. […] According to Dr. Friedman, he has had success treating both cutaneous and nail disease with ixekizumab (Taltz, Lilly) and secukinumab (Cosentyx, Novartis). […] Interestingly, one case report showed benefit with dupilumab (Dupixent, Sanofi and Regeneron) for severe lichen planus. […] According to Dr. Friedman, the overall takeaway here is that dermatologists need to be creative with available options for treating lichen planus. […] The end all be all is we need things on label because that then allows easier access, hopefully, to these drugs.

• #31 Lichen planus: Symptoms, Types, and Treatment with Images — DermNet

  https://dermnetnz.org/topics/lichen-planus

  Anecdotal success is reported from long courses of antibiotics e.g. metronidazole, sulfasalazine, antifungals (such as griseofulvin), and JAK inhibitors. […] In oral lichen planus, limited evidence is found in using apremilast. Successful treatment of oral and cutaneous lichen planus with adalimumab has previously been reported. […] Tildrakizumab has been shown to demonstrate positive results in erosive oral lichen planus in an isolated case study. […] For more information see, oral lichen planus and erosive lichen planus.

• #32 Successful Treatment of Lichen Planus With Oral Upadacitinib – JDDonline – Journal of Drugs in Dermatology

  https://jddonline.com/articles/successful-treatment-of-lichen-planus-with-oral-upadacitinib-S1545961623P1058X/

  Lichen planus is an auto-inflammatory skin disorder marked by intensely pruritic, violaceous papules that commonly affect the extremities of middle-aged adults. There are several treatment options available, but alternative therapies to target disease refractory to standard interventions remain necessary. […] Though they have not been FDA-approved for lichen planus, Janus kinase (JAK) inhibitors have demonstrated significant potential as a therapeutic intervention across an array of dermatoses. […] Herein, we present a case of refractory, biopsy-proven lichen planus successfully treated with the oral JAK1 inhibitor, upadacitinib. […] First-line treatment options consist of corticosteroids, retinoids, and phototherapy. Other medications with reported benefits include methotrexate, metronidazole, and sulfasalazine. […] Upadacitinib was started at the dose of 15 mg by mouth once daily. In addition, she was supplemented with hydroxyzine as needed for pruritus at bedtime and topical tacrolimus ointment.

• #33 Photodynamic therapy in oral lichen planus: A prospective case-controlled pilot study | Scientific Reports

  https://www.nature.com/articles/s41598-020-58548-9

  Oral lichen planus (OLP) is a common, chronic relapsing inflammatory disorder of the mucous membranes, which causes major discomfort. Current treatment includes topical/systemic glucocorticoids, immune modulators and systemic immunosuppressants, which may lead to considerable side-effects. The aim of this study was to determine the clinical and immunological efficacy of photodynamic therapy (PDT) in OLP as an alternative, easy-to-use, safe and non-invasive treatment. […] PDT led to a statistically significant reduction of clinical parameters (lesion size, ABSIS, Thongprasom-score) and improvement of all evaluated quality-of-life (QOL) items. […] PDT treatment in OLP leads to lesion reduction and improvement of QOL, and induces local and systemic anti-inflammatory effects. The study identifies PDT as a novel therapeutic option in OLP.

• #34 Photodynamic therapy in oral lichen planus: A prospective case-controlled pilot study | Scientific Reports

  https://www.nature.com/articles/s41598-020-58548-9

  At present, topical corticosteroids are widely accepted as the primary choice of OLP therapy, but other therapeutical protocols have also been investigated, i.e. topical and systemic retinoids, calcineurin inhibitors, aloe-vera, and thalidomide. […] Photodynamic therapy (PDT) as an easy-to-use and safe treatment option induces cell and tissue damage by combining the use of a photosensitizer and light that activates the photosensitizer by exposure to low-level visible light in an appropriate wavelength. […] The results show a reduction of lesion size and decrease of ABSIS and Thongprasom scores and an improvement of QOL parameters. […] PDT treatment led to a highly significant reduction of the size of OLP lesions, also reflected by a significant decrease of the ABSIS scores. […] PDT leads to a significant improvement of clinical and QOL parameters in OLP which are associated with local and systemic anti-inflammatory effects. PDT holds promise as a novel therapeutic option in OLP and may deliver new insights for a better understanding of OLP pathogenesis in general.

• #35 How to Stop Lichen Planus from Spreading on Your Body

  https://www.healthline.com/health/how-to-stop-lichen-planus-from-spreading

  Other therapies: Doctors can prescribe mouthwashes, gels, sprays, or lozenges that contain antiseptics or corticosteroids to help with lichen planus of the mouth. […] While medical treatments are crucial for managing lichen planus, you can also take steps at home to soothe your symptoms and prevent flare-ups: […] Practice healthy hygiene: Regularly clean the affected areas to prevent infections. For oral lichen planus, a soft toothbrush and alcohol-free mouthwash can help prevent irritation. […] There is no cure for lichen planus. But medications and other therapies, along with healthy hygiene practices and skin care, can help control flare-ups and soothe irritation. If you notice your condition worsening or spreading, be sure to seek medical advice.

• #36 Lichen planus

  https://www.nhs.uk/conditions/lichen-planus/

  Lichen planus on your skin usually gets better on its own in about 9 to 18 months. […] Creams and ointments from a GP can help control the rash and ease itching. […] If creams and ointments do not work, or you have severe lichen planus, steroid tablets or treatment with a special kind of light (light therapy) can help. […] Lichen planus in your mouth can last for several years. Mouthwashes and sprays from a GP can help ease symptoms like burning or sore gums. […] If you have lichen planus on your skin: wash with warm water avoid soaps and body washes. […] a GP may prescribe a moisturising treatment for the skin (emollient) to use on the rash. […] If you have lichen planus on your genitals: try to have showers rather than baths. […] If you have lichen planus in your mouth: avoid salty, spicy and acidic foods, or alcohol, if they make your mouth sore. […] use a mouthwash that does not contain alcohol, if it makes your mouth sore.

• #37 Lichen Planus: What It Is, Causes, Types & Treatments

  https://my.clevelandclinic.org/health/diseases/17723-lichen-planus

  Oatmeal: The best way to use oatmeal on your lichen planus skin rash is to grind it into a fine powder (colloidal oatmeal) in a blender or food processor. Mix the oatmeal powder with warm water until it becomes a thick, sticky paste. Apply enough of the oatmeal paste to cover your rash completely. After at least 10 minutes, wipe off the paste with a clean towel. […] Therapy and home remedies can provide relief if you experience any symptoms.

• #38 Get Lichen Planus Treatment Online – TeleMed2U

  https://www.telemed2u.com/dermatology/lichen-planus

  Self-care measures include: Practice good oral care, (brush twice and floss every day), including regular dentist visits. Keeping the mouth clean helps reduce symptoms, and lowers your infection risk. […] Manage stress, it can worsen symptoms and cause flare-ups. […] Use cool compresses and oatmeal baths to reduce itching. […] Protect skin from injuries. Even a small injury can cause an outbreak.

• #39 Lichen Planus Treatment – Colorado Springs & Monument, CO

  https://www.summitdermatology.com/conditions/lichen-planus/

  Treatment for lichen planus includes the following options: […] Topical corticosteroid cream or ointment […] Antihistamines to help reduce itching […] Corticosteroids (prednisone) as pills or as a shot […] Tacrolimus ointment or pimecrolimus cream […] Immunosuppressant medications given as a prescription pill. […] In addition to prescription medication, some recommendations for the oral form of LP include: […] Do not smoke, do not chew tobacco, do not drink alcohol […] Get a screening for oral cancer every 6-12 months with your dentist […] Brush your teeth twice daily and floss daily […] Avoid spicy foods, citrus fruits and juices, tomatoes or tomato products, salty snack foods, and drinks that contain caffeine (coffee, tea, and soda).

• #40 Oral Lichen Planus: Symptoms, Causes & Treatment

  https://my.clevelandclinic.org/health/diseases/17875-oral-lichen-planus

  Corticosteroids. You may get a gel or ointment to rub on the lesions. If that doesnt work, your provider may prescribe this medicine as a shot or a pill that you take by mouth. […] Calcineurin inhibitors. Providers may prescribe this type of medicine if corticosteroids arent helping. The most common type is an ointment you rub on the lesions. […] Pain relievers. Often, over-the-counter medicines reduce pain from OLP. Options include acetaminophen and NSAIDs. You may need medicines like lidocaine to numb the pain. […] Making small changes to your routine can help prevent flare-ups. Not everyone has the same triggers. But for many people, it helps to: […] Avoid acidic, crunchy, salty or spicy foods […] Avoid drinking alcohol or using tobacco products […] Use a soft-bristled toothbrush or an electric toothbrush on the lowest setting

• #41 Oral Lichen Planus: Symptoms, Causes & Treatment

  https://my.clevelandclinic.org/health/diseases/17875-oral-lichen-planus

  Use mild, unflavored toothpaste and dental floss (no mint, cinnamon or sodium lauryl sulfate) […] Practice stress management techniques daily […] Stop taking medications that cause flare-ups. […] Most people notice major symptom relief within a month of using topical corticosteroids (the type you rub on the lesions). With a shot, it may take two to three treatments to feel better. With pills, it may take a few weeks. […] If youre experiencing a symptom flare-up, let your provider know. They can start you on treatments that can help you feel better. […] Your healthcare provider can explain what you should expect based on your symptoms. […] Speak to a therapist if the stress of managing your condition is taking a toll on your emotional health. Many people with long-term conditions benefit from therapy to help keep stressors at bay. This is especially important with OLP, as stress is a common trigger for symptom flare-ups.

• #42 Oral Lichen Planus

  https://www.aaom.com/oral-lichen-planus

  A: Often the reticular form of oral lichen planus does not require any treatment, except periodic observation by a health care professional. The erosive and ulcerative forms can usually be controlled with the use of topical corticosteroids. In some cases, systemic steroids or other medicines may be prescribed by your doctor. […] A goal of therapy is to convert bothersome erosive or ulcerative oral lichen planus to the asymptomatic reticular form. Individuals with oral lichen planus often require some form of maintenance therapy to keep their disease under control. Oral lichen planus can be controlled but often will exhibit disease flare-ups requiring additional. Finally, following a healthy lifestyle consisting of a well-balanced diet, exercise and stress reduction is also beneficial. […] All patients with oral lichen planus should have a periodic evaluation to assess the efficacy of therapy and to monitor for suspicious changes. If your oral lichen planus does not respond to treatment or if you should notice a significant change, you should contact your health care provider for further evaluation.

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