Materiały źródłowe

• #1 Chlamydia – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK537286/

  Chlamydia trachomatis is responsible for the greatest number of sexually transmitted infections and the majority of infection-related of blindness worldwide. […] This activity reviews the evaluation and management of Chlamydia trachomatis infections and highlights the role of the interprofessional team in the care of affected patients. […] Describe the appropriate treatment of chlamydia trachomatis infections. […] Treatment for uncomplicated urogenital chlamydia infection is with azithromycin. Doxycycline is an alternative, but azithromycin is preferred as it is a single-dose therapy. Other alternatives include erythromycin, levofloxacin, and ofloxacin. […] The goal of treatment is the prevention of complications associated with infection (e.g., PID, infertility), to decrease the risk of transmission, and the resolution of symptoms.

• #2 Chlamydia and LGV guide: Key information and resources – Canada.ca

  https://www.canada.ca/en/public-health/services/infectious-diseases/sexual-health-sexually-transmitted-infections/canadian-guidelines/chlamydia-lgv.html

  C. trachomatis is the most common reportable sexually transmitted infection in Canada. If not treated, C. trachomatis can spread from a local site of inoculation and lead to serious complications and/or sequelae, such as pelvic inflammatory disease (PID), ectopic pregnancy, infertility, chronic pelvic pain, epididymo-orchitis and reactive arthritis. […] Universal annual screening is recommended in all sexually active adults and adolescents under the age of 30 years. For persons with multiple sexual partners or a new partner since last tested, offer screening every three to six months. […] Nucleic acid amplification tests (NAAT) are the most sensitive tests for detecting C. trachomatis. […] Anogenital and conjunctival chlamydia in non-pregnant and non-lactating adults: Doxycycline 100 mg PO BID for 7 days or azithromycin 1 g PO in a single dose. Refer to the Treatment section of the Chlamydia Guide for treatment recommendations for pregnant or lactating people and people nine to 18 years of age.

• #2 Chlamydial Infections – STI Treatment GuidelinesMinusSASstats

  https://www.cdc.gov/std/treatment-guidelines/chlamydia.htm

  Chlamydia screening programs have been demonstrated to reduce PID rates among women. […] Treating persons with C. trachomatis prevents adverse reproductive health complications and continued sexual transmission. Furthermore, treating their sex partners can prevent reinfection and infection of other partners. […] Recommended Regimens for Chlamydial Infection Among Adolescents and Adults: Doxycycline 100 mg orally 2 times/day for 7 days. […] A meta-analysis and a Cochrane systematic review evaluated data from randomized clinical trials of azithromycin versus doxycycline for treating urogenital chlamydial infection determined that microbiologic treatment failure among men was higher for azithromycin than for doxycycline. […] Available evidence supports that doxycycline is efficacious for C. trachomatis infections of urogenital, rectal, and oropharyngeal sites.

• #3 Chlamydial Infections – STI Treatment GuidelinesMinusSASstats

  https://www.cdc.gov/std/treatment-guidelines/chlamydia.htm

  Chlamydia screening programs have been demonstrated to reduce PID rates among women. […] Treating persons with C. trachomatis prevents adverse reproductive health complications and continued sexual transmission. Furthermore, treating their sex partners can prevent reinfection and infection of other partners. […] Recommended Regimens for Chlamydial Infection Among Adolescents and Adults: Doxycycline 100 mg orally 2 times/day for 7 days. […] A meta-analysis and a Cochrane systematic review evaluated data from randomized clinical trials of azithromycin versus doxycycline for treating urogenital chlamydial infection determined that microbiologic treatment failure among men was higher for azithromycin than for doxycycline. […] Available evidence supports that doxycycline is efficacious for C. trachomatis infections of urogenital, rectal, and oropharyngeal sites.

• #4 RECOMMENDATIONS FOR TREATMENT OF CHLAMYDIAL INFECTIONS – WHO Guidelines for the Treatment of Chlamydia trachomatis – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK379708/

  WHO Guidelines for the Treatment of Chlamydia trachomatis. Geneva: World Health Organization; 2016. […] The following nine recommendations apply to adults, adolescents (10-19 years of age), people living with HIV, and key populations, including sex workers, men who have sex with men (MSM) and transgender persons. Specific recommendations have also been developed for ophthalmia neonatorum caused by C. trachomatis. […] For people with uncomplicated genital chlamydia, the WHO STI guideline suggests one of the following options: azithromycin 1 g orally as a single oral dose or doxycycline 100 mg orally twice a day for 7 days […] or one of these alternatives: tetracycline 500 mg orally four times a day for 7 days, erythromycin 500 mg orally twice a day for 7 days, ofloxacin 200-400 mg orally twice a day for 7 days.

• #5 Chlamydial Infections – STI Treatment GuidelinesMinusSASstats

  https://www.cdc.gov/std/treatment-guidelines/chlamydia.htm

  Chlamydia screening programs have been demonstrated to reduce PID rates among women. […] Treating persons with C. trachomatis prevents adverse reproductive health complications and continued sexual transmission. Furthermore, treating their sex partners can prevent reinfection and infection of other partners. […] Recommended Regimens for Chlamydial Infection Among Adolescents and Adults: Doxycycline 100 mg orally 2 times/day for 7 days. […] A meta-analysis and a Cochrane systematic review evaluated data from randomized clinical trials of azithromycin versus doxycycline for treating urogenital chlamydial infection determined that microbiologic treatment failure among men was higher for azithromycin than for doxycycline. […] Available evidence supports that doxycycline is efficacious for C. trachomatis infections of urogenital, rectal, and oropharyngeal sites.

• #6 Chlamydial and Gonococcal Infections: Screening, Diagnosis, and Treatment | AAFP

  https://www.aafp.org/pubs/afp/issues/2022/0400/p388.html

  Preferred chlamydia treatment is a seven-day course of doxycycline, 100 mg taken by mouth twice per day. […] Doxycycline should be used to treat chlamydia in nonpregnant people. […] Although spontaneous clearance of chlamydial infections is possible, people with positive test results should always be treated. […] The recommended treatment for non-pregnant people is now doxycycline, 100 mg, twice per day for seven days. […] Treatment regimens are reviewed in Table 7. […] If symptoms do not resolve or a test is persistently positive in a situation in which reinfection seems unlikely, an infectious disease specialist and local health department should be consulted in case of possible antimicrobial resistance.

• #7 Chlamydial Infections – STI Treatment GuidelinesMinusSASstats

  https://www.cdc.gov/std/treatment-guidelines/chlamydia.htm

  Chlamydia screening programs have been demonstrated to reduce PID rates among women. […] Treating persons with C. trachomatis prevents adverse reproductive health complications and continued sexual transmission. Furthermore, treating their sex partners can prevent reinfection and infection of other partners. […] Recommended Regimens for Chlamydial Infection Among Adolescents and Adults: Doxycycline 100 mg orally 2 times/day for 7 days. […] A meta-analysis and a Cochrane systematic review evaluated data from randomized clinical trials of azithromycin versus doxycycline for treating urogenital chlamydial infection determined that microbiologic treatment failure among men was higher for azithromycin than for doxycycline. […] Available evidence supports that doxycycline is efficacious for C. trachomatis infections of urogenital, rectal, and oropharyngeal sites.

• #8 Chlamydial Infections – STI Treatment GuidelinesMinusSASstats

  https://www.cdc.gov/std/treatment-guidelines/chlamydia.htm

  Chlamydia screening programs have been demonstrated to reduce PID rates among women. […] Treating persons with C. trachomatis prevents adverse reproductive health complications and continued sexual transmission. Furthermore, treating their sex partners can prevent reinfection and infection of other partners. […] Recommended Regimens for Chlamydial Infection Among Adolescents and Adults: Doxycycline 100 mg orally 2 times/day for 7 days. […] A meta-analysis and a Cochrane systematic review evaluated data from randomized clinical trials of azithromycin versus doxycycline for treating urogenital chlamydial infection determined that microbiologic treatment failure among men was higher for azithromycin than for doxycycline. […] Available evidence supports that doxycycline is efficacious for C. trachomatis infections of urogenital, rectal, and oropharyngeal sites.

• #9 RECOMMENDATIONS FOR TREATMENT OF CHLAMYDIAL INFECTIONS – WHO Guidelines for the Treatment of Chlamydia trachomatis – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK379708/

  WHO Guidelines for the Treatment of Chlamydia trachomatis. Geneva: World Health Organization; 2016. […] The following nine recommendations apply to adults, adolescents (10-19 years of age), people living with HIV, and key populations, including sex workers, men who have sex with men (MSM) and transgender persons. Specific recommendations have also been developed for ophthalmia neonatorum caused by C. trachomatis. […] For people with uncomplicated genital chlamydia, the WHO STI guideline suggests one of the following options: azithromycin 1 g orally as a single oral dose or doxycycline 100 mg orally twice a day for 7 days […] or one of these alternatives: tetracycline 500 mg orally four times a day for 7 days, erythromycin 500 mg orally twice a day for 7 days, ofloxacin 200-400 mg orally twice a day for 7 days.

• #10 RECOMMENDATIONS FOR TREATMENT OF CHLAMYDIAL INFECTIONS – WHO Guidelines for the Treatment of Chlamydia trachomatis – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK379708/

  While good practice based on evidence of large net benefit dictates that patients should be treated for chlamydial infection, the choice of treatment may depend on the convenience of dosage, the cost and quality of the medicines in different settings, and equity considerations. […] In summary, there was moderate quality evidence for trivial differences in benefits and harms between azithromycin and doxycycline, and although the cost of azithromycin is higher, the single dose may make it more convenient to use than doxycycline. […] In people with anorectal chlamydial infection, the WHO STI guideline suggests using doxycycline 100 mg orally twice daily for 7 days over azithromycin 1 g orally single dose. […] In pregnant women with genital chlamydial infection, the WHO STI guideline recommends using azithromycin over erythromycin.

• #11 RECOMMENDATIONS FOR TREATMENT OF CHLAMYDIAL INFECTIONS – WHO Guidelines for the Treatment of Chlamydia trachomatis – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK379708/

  WHO Guidelines for the Treatment of Chlamydia trachomatis. Geneva: World Health Organization; 2016. […] The following nine recommendations apply to adults, adolescents (10-19 years of age), people living with HIV, and key populations, including sex workers, men who have sex with men (MSM) and transgender persons. Specific recommendations have also been developed for ophthalmia neonatorum caused by C. trachomatis. […] For people with uncomplicated genital chlamydia, the WHO STI guideline suggests one of the following options: azithromycin 1 g orally as a single oral dose or doxycycline 100 mg orally twice a day for 7 days […] or one of these alternatives: tetracycline 500 mg orally four times a day for 7 days, erythromycin 500 mg orally twice a day for 7 days, ofloxacin 200-400 mg orally twice a day for 7 days.

• #12 Chlamydia: Diagnosis, Tests, Treatment, Medication

  https://www.webmd.com/sexual-conditions/understanding-chlamydia-treatment

  Chlamydia can be well treated with antibiotics and is cured in 95% of uncomplicated cases. […] Chlamydia is an STD that can only be cured with treatment. It wont go away on its own. If you dont get the right treatment, chlamydia can lead to serious issues such as fertility issues or arthritis. […] If you are diagnosed with chlamydia, your doctor will prescribe antibiotics that you take by mouth. […] Chlamydia is well treated with antibiotics. These antibiotics include: Azithromycin, a single dose of 1 gram; Doxycycline, 100 milligrams twice a day for 7 days; Tetracycline, 500 milligrams four times a day for 7 days; Erythromycin, 500 milligrams twice a day for 7 days; Ofloxacin, 200-400 milligrams twice a day for 7 days. […] Chlamydia cannot go away on its own, but treatment with antibiotics can cure it. Leaving chlamydia untreated can lead to serious and long-term health problems like: Increased risk of getting and spreading HIV; Fertility problems; Pelvic inflammatory disease (PID); Pre-term delivery; Ectopic pregnancy; Swollen joints (arthritis); Inflamed eyes; Stomach and pelvic pain.

• #13 Chlamydia – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK537286/

  Verification of cure should occur three weeks after treatment completion, and retesting should be performed three months after treatment. […] The World Health Organization (WHO) recommendations for treatment of uncomplicated genital chlamydia infections are the following: Azithromycin 1000 mg orally as a single dose or Doxycycline 100 mg orally twice a day for seven days, or one of these alternatives: tetracycline 500 mg by mouth four times a day for seven days, erythromycin 500 mg orally twice daily for 7 days, or ofloxacin 200-400 mg orally twice daily for 7 days. […] In anorectal chlamydial infections, the WHO recommendation is oral doxycycline 100 mg twice daily for 7 days over oral azithromycin 1 g as a single dose. […] Azithromycin recommended over erythromycin, amoxicillin, and erythromycin.

• #14

  https://bpac.org.nz/2019/chlamydia-gonorrhoea.aspx

  New evidence suggests that a seven-day course of doxycycline may be more appropriate than a stat dose of azithromycin as a first-line treatment for chlamydia infection. […] A single stat dose of azithromycin is currently the recommended first-line antibiotic regimen for treating genital chlamydia infection, and it is effective in 94% of patients. An alternative treatment is a seven day course of doxycycline, which is effective in 97% of patients with genital chlamydia infection. […] However, azithromycin is less effective at treating rectal chlamydia infection than doxycycline. […] A meta-analysis reported that the average efficacy of a stat dose of azithromycin for treating rectal chlamydia was 83%, compared to 99% for a seven day course of doxycycline. […] Doxycycline is more effective than azithromycin for treating genital or rectal chlamydia and should be considered as a first-line treatment option for females and males with chlamydia.

• #15 Chlamydial Infections – STI Treatment GuidelinesMinusSASstats

  https://www.cdc.gov/std/treatment-guidelines/chlamydia.htm

  Recommended Regimen for Chlamydial Infection During Pregnancy: Azithromycin 1 g orally in a single dose. […] Recommended Regimen for Chlamydial Infection Among Neonates: Erythromycin base or ethylsuccinate 50 mg/kg body weight/day orally, divided into 4 doses daily for 14 days. […] Follow-up of infants is recommended to determine whether the initial treatment was effective.

• #16 Chlamydia – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK537286/

  Verification of cure should occur three weeks after treatment completion, and retesting should be performed three months after treatment. […] The World Health Organization (WHO) recommendations for treatment of uncomplicated genital chlamydia infections are the following: Azithromycin 1000 mg orally as a single dose or Doxycycline 100 mg orally twice a day for seven days, or one of these alternatives: tetracycline 500 mg by mouth four times a day for seven days, erythromycin 500 mg orally twice daily for 7 days, or ofloxacin 200-400 mg orally twice daily for 7 days. […] In anorectal chlamydial infections, the WHO recommendation is oral doxycycline 100 mg twice daily for 7 days over oral azithromycin 1 g as a single dose. […] Azithromycin recommended over erythromycin, amoxicillin, and erythromycin.

• #17 Diagnosis and Treatment of Chlamydia trachomatis Infection | AAFP

  https://www.aafp.org/pubs/afp/issues/2006/0415/p1411.html

  Chlamydial infection in newborns can cause ophthalmia neonatorum. Treatment options for uncomplicated urogenital infections include a single 1-g dose of azithromycin orally, or doxycycline at a dosage of 100 mg orally twice per day for seven days. The recommended treatment during pregnancy is erythromycin base or amoxicillin. […] Azithromycin (Zithromax) or doxycycline (Vibramycin) is recommended for the treatment of uncomplicated genitourinary chlamydial infection. […] For uncomplicated genitourinary chlamydial infection, the CDC recommends 1 g azithromycin (Zithromax) orally in a single dose, or 100 mg doxycycline (Vibramycin) orally twice per day for seven days. […] Doxycycline and ofloxacin (Floxin) are contraindicated during pregnancy; therefore, the CDC recommends erythromycin base or amoxicillin for the treatment of chlamydial infection in pregnant women.

• #18 RECOMMENDATIONS FOR TREATMENT OF CHLAMYDIAL INFECTIONS – WHO Guidelines for the Treatment of Chlamydia trachomatis – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK379708/

  While good practice based on evidence of large net benefit dictates that patients should be treated for chlamydial infection, the choice of treatment may depend on the convenience of dosage, the cost and quality of the medicines in different settings, and equity considerations. […] In summary, there was moderate quality evidence for trivial differences in benefits and harms between azithromycin and doxycycline, and although the cost of azithromycin is higher, the single dose may make it more convenient to use than doxycycline. […] In people with anorectal chlamydial infection, the WHO STI guideline suggests using doxycycline 100 mg orally twice daily for 7 days over azithromycin 1 g orally single dose. […] In pregnant women with genital chlamydial infection, the WHO STI guideline recommends using azithromycin over erythromycin.

• #19 RECOMMENDATIONS FOR TREATMENT OF CHLAMYDIAL INFECTIONS – WHO Guidelines for the Treatment of Chlamydia trachomatis – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK379708/

  In pregnant women with genital chlamydial infection, the WHO STI guideline suggests using azithromycin over amoxicillin. […] In pregnant women with genital chlamydial infection, the WHO STI guideline suggests using amoxicillin over erythromycin. […] In adults and adolescents with LGV, the WHO STI guideline suggests using doxycycline 100 mg orally twice daily for 21 days over azithromycin 1 g orally, weekly for 3 weeks. […] In neonates with chlamydial conjunctivitis, the WHO STI guideline recommends using oral azithromycin 20 mg/kg/day orally, one dose daily for 3 days, over erythromycin 50 mg/kg/day orally, in four divided doses daily for 14 days. […] For all neonates, the WHO STI guideline recommends topical ocular prophylaxis for the prevention of gonococcal and chlamydial ophthalmia neonatorum.

• #20 Diagnosis and Treatment of Chlamydia trachomatis Infection | AAFP

  https://www.aafp.org/pubs/afp/issues/2006/0415/p1411.html

  Chlamydial infection in newborns can cause ophthalmia neonatorum. Treatment options for uncomplicated urogenital infections include a single 1-g dose of azithromycin orally, or doxycycline at a dosage of 100 mg orally twice per day for seven days. The recommended treatment during pregnancy is erythromycin base or amoxicillin. […] Azithromycin (Zithromax) or doxycycline (Vibramycin) is recommended for the treatment of uncomplicated genitourinary chlamydial infection. […] For uncomplicated genitourinary chlamydial infection, the CDC recommends 1 g azithromycin (Zithromax) orally in a single dose, or 100 mg doxycycline (Vibramycin) orally twice per day for seven days. […] Doxycycline and ofloxacin (Floxin) are contraindicated during pregnancy; therefore, the CDC recommends erythromycin base or amoxicillin for the treatment of chlamydial infection in pregnant women.

• #21 Chlamydial Infections – STI Treatment GuidelinesMinusSASstats

  https://www.cdc.gov/std/treatment-guidelines/chlamydia.htm

  Recommended Regimen for Chlamydial Infection During Pregnancy: Azithromycin 1 g orally in a single dose. […] Recommended Regimen for Chlamydial Infection Among Neonates: Erythromycin base or ethylsuccinate 50 mg/kg body weight/day orally, divided into 4 doses daily for 14 days. […] Follow-up of infants is recommended to determine whether the initial treatment was effective.

• #22 Diagnosis and Treatment of Chlamydia trachomatis Infection | AAFP

  https://www.aafp.org/pubs/afp/issues/2006/0415/p1411.html

  Ophthalmia neonatorum can be treated with erythromycin base or ethylsuccinate at a dosage of 50 mg per kg per day orally, divided into four doses per day for 14 days. […] Like ophthalmia neonatorium, pneumonia secondary to C. trachomatis is treated with erythromycin base or ethylsuccinate at a dosage of 50 mg per kg per day orally, divided into four doses per day for 14 days.

• #23 RECOMMENDATIONS FOR TREATMENT OF CHLAMYDIAL INFECTIONS – WHO Guidelines for the Treatment of Chlamydia trachomatis – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK379708/

  In pregnant women with genital chlamydial infection, the WHO STI guideline suggests using azithromycin over amoxicillin. […] In pregnant women with genital chlamydial infection, the WHO STI guideline suggests using amoxicillin over erythromycin. […] In adults and adolescents with LGV, the WHO STI guideline suggests using doxycycline 100 mg orally twice daily for 21 days over azithromycin 1 g orally, weekly for 3 weeks. […] In neonates with chlamydial conjunctivitis, the WHO STI guideline recommends using oral azithromycin 20 mg/kg/day orally, one dose daily for 3 days, over erythromycin 50 mg/kg/day orally, in four divided doses daily for 14 days. […] For all neonates, the WHO STI guideline recommends topical ocular prophylaxis for the prevention of gonococcal and chlamydial ophthalmia neonatorum.

• #24 Chlamydial Infections – STI Treatment GuidelinesMinusSASstats

  https://www.cdc.gov/std/treatment-guidelines/chlamydia.htm

  Recommended Regimen for Chlamydial Infection During Pregnancy: Azithromycin 1 g orally in a single dose. […] Recommended Regimen for Chlamydial Infection Among Neonates: Erythromycin base or ethylsuccinate 50 mg/kg body weight/day orally, divided into 4 doses daily for 14 days. […] Follow-up of infants is recommended to determine whether the initial treatment was effective.

• #25 Chlamydia – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK537286/

  The WHO recommends the following for the treatment of lymphogranuloma venereum (LGV): In adults and adolescents with lymphogranuloma venereum, the guidelines suggest doxycycline 100 mg orally twice a day for 21 days over azithromycin 1 g orally weekly for 3 weeks. […] Oral erythromycin is the preferred treatment for both conjunctivitis and pneumonia in the neonate. Azithromycin is an acceptable alternative.

• #26 Chlamydia and LGV guide: Treatment and follow-up – Canada.ca

  https://www.canada.ca/en/public-health/services/infectious-diseases/sexual-health-sexually-transmitted-infections/canadian-guidelines/chlamydia-lgv/treatment-follow-up.html

  Treatment and follow-up of Chlamydia trachomatis infections (including lymphogranuloma venereum (LGV)). […] The following treatment options are recommended in the absence of contraindication. Consult product monographs for contraindications and side effects. […] Caution: Refer to the health advisory issued by Health Canada about azithromycin and risk of cardiovascular complications and death. […] Non-pregnant and non-lactating adults: Doxycycline 100 mg PO BID for 7 days or Azithromycin 1 g PO in a single dose. […] Pregnant and lactating people: Azithromycin 1 g PO in a single dose or Amoxicillin 500 mg PO TID for 7 days or Erythromycin 2 g/day PO in divided doses for 7 days or Erythromycin 1g/day PO in divided doses for 14 days. […] LGV: Doxycycline 100 mg PO BID for 21 days or Azithromycin 1g PO once weekly for 3 weeks.

• #27 Chlamydia (Chlamydial Genitourinary Infections) Treatment & Management: Approach Considerations, Antibiotic Therapy, Prevention

  https://emedicine.medscape.com/article/214823-treatment

  The keys to management of chlamydial infections are (1) arriving at the correct diagnosis and (2) ensuring that the patient complies with treatment. […] Begin antibiotic therapy as soon as possible. Consider compliance, cost, and potential adverse effects. Consider treatment for possible gonorrhea coinfection. […] Treatment of genitourinary chlamydial infection is clearly indicated when the infection is diagnosed or suspected. Chlamydiae are susceptible to antibiotics that interfere with DNA and protein synthesis, including tetracyclines, macrolides, and quinolones. […] CDC recommends azithromycin and doxycycline as first-line drugs for the treatment of chlamydial infection. […] Medical treatment with these agents is 95% effective. […] For many years, standard therapy for uncomplicated genital tract infection has been doxycycline 100 mg orally twice daily for 7 days. However, azithromycin given as a single 1-g dose is as effective as a 7-day course of doxycycline.

• #28 Different options for chlamydia treatment – STDcenterNY

  https://stdcenterny.com/chlamydia-treatment.html

  This treatment is called expedited partner therapy (EPT). It is treatment that a sexual partner of an infected person can get without seeing a doctor or being getting tested. […] First-line medications have demonstrated satisfying results. According to the CDC, azithromycin has been shown to be effective in 97% of people with urogenital infection, and doxycycline has a 98% efficacy rate. […] Symptoms tend to resolve quite quickly. Pain and burning during urination resolve within a few days to a week and other symptoms, such as pelvic pain and pain in the testicles, may resolve within two weeks. […] It is crucial to strictly avoid sexual contact for seven days after finishing the treatment, regardless of the treatment regimen. […] Yes. In 2006, the CDC approved expedited partner therapy (EPT). This therapy was designed for sexual partners of chlamydia-positive persons.

• #29

  https://bpac.org.nz/2019/chlamydia-gonorrhoea.aspx

  New evidence suggests that a seven-day course of doxycycline may be more appropriate than a stat dose of azithromycin as a first-line treatment for chlamydia infection. […] A single stat dose of azithromycin is currently the recommended first-line antibiotic regimen for treating genital chlamydia infection, and it is effective in 94% of patients. An alternative treatment is a seven day course of doxycycline, which is effective in 97% of patients with genital chlamydia infection. […] However, azithromycin is less effective at treating rectal chlamydia infection than doxycycline. […] A meta-analysis reported that the average efficacy of a stat dose of azithromycin for treating rectal chlamydia was 83%, compared to 99% for a seven day course of doxycycline. […] Doxycycline is more effective than azithromycin for treating genital or rectal chlamydia and should be considered as a first-line treatment option for females and males with chlamydia.

• #30 Chlamydia: Symptoms (Men & Women), Diagnosis, Treatment

  https://www.webmd.com/sexual-conditions/chlamydia

  Chlamydia is curable. Because its a bacterial infection, doctors can treat it with antibiotics. If you have chlamydia, your doctor will prescribe oral antibiotics, such as azithromycin (Zithromax) or doxycycline. […] With treatment, your infection should clear up in about a week or two. Its important to finish all of your antibiotics, even if you feel better. […] If you have a vagina and your chlamydia infection is severe, you may need treatment in a hospital, IV antibiotics (medicine given through a vein), and pain medicine. […] Its important for your partner(s) to get treated as well, so you can avoid getting infected again and prevent spreading the infection to others. […] After you finish the antibiotics, you should get retested after 3 months to be sure the infection is cured. This is particularly important if you arent sure your partner(s) were treated. But do get tested even if your partner(s) were treated.

• #31 Chlamydia treatment — Chelsea and Westminster Hospital NHS Foundation Trust

  https://www.chelwest.nhs.uk/services/hiv-sexual-health/chlamydia-treatment

  In women using the combined contraceptive pill or patch, the antibiotics used in your chlamydia treatment may temporarily reduce the effectiveness of your contraception. […] After you have begun your course of chlamydia treatment, you should start to notice an improvement in your symptoms within a few days. Generally, most symptoms should resolve completely within 24 weeks. […] If you are diagnosed with chlamydia you may need to inform anyone you have had sex with within the last six months as they may also be infected. […] You should not have oral, anal or vaginal sex during your course of chlamydia treatment or for seven days after a single dose of chlamydia treatment and also until your current partner completes their treatment and until both you and your partners symptoms have abated.

• #32

  https://111.wales.nhs.uk/chlamydia/

  Chlamydia can usually be treated easily with antibiotics. […] You may be given a course of doxycycline to take for a week or azithromycin to take once a day for 3 days. […] It’s important that your current sexual partner and any other recent sexual partners you have had are also tested and treated to help stop the spread of the infection. […] Chlamydia can usually be effectively treated with antibiotics. More than 95% of people will be cured if they take their antibiotics correctly. […] The two most commonly prescribed antibiotics for chlamydia are: doxycycline taken every day for a week and azithromycin – 1 dose of 1g, followed by 500mg once a day for 2 days. […] If you had doxycycline, you shouldn’t have sex including vaginal, oral or anal sex, even with a condom until both you and your partner(s) have completed treatment. […] If you had azithromycin, you should wait 7 days after treatment before having sex (including oral sex). […] If you test positive for chlamydia, it’s important that your current sexual partner and any other recent sexual partners you’ve had are also tested and treated.

• #33 Chlamydia (Chlamydial Genitourinary Infections) Treatment & Management: Approach Considerations, Antibiotic Therapy, Prevention

  https://emedicine.medscape.com/article/214823-treatment

  Azithromycin also has been shown to be effective in the treatment of nongonococcal urethritis, whether related to C trachomatis, genital mycoplasmas, or other organisms. […] Lower genital infections caused by Chlamydia can be treated with single-dose, directly observed treatment. […] Treatment also is indicated for sexual partners of the index case if the time of the last sexual encounter was within 60 days of onset, and it should be considered for longer periods for the last sexual partner. […] Guidelines from the CDC recommend azithromycin 1 g orally as a single dose. Alternatives include amoxicillin 500 mg orally three times a day for 7 days as the preferred drug regimens for treating chlamydial infections in pregnancy. […] Test-of-cure to document chlamydial eradication (preferably via NAAT) 3-4 weeks after therapy completion is recommended.

• #34 Chlamydia and LGV guide: Key information and resources – Canada.ca

  https://www.canada.ca/en/public-health/services/infectious-diseases/sexual-health-sexually-transmitted-infections/canadian-guidelines/chlamydia-lgv.html

  LGV: Doxycycline 100 mg PO BID for 21 days. […] Test of cure (TOC) is recommended three weeks after completion of treatment when compliance to treatment is suboptimal, an alternative treatment regimen is used or the person is prepubertal or pregnant. […] LGV: TOC is recommended three weeks after completion of treatment. Follow people until TOC for chlamydia is negative and symptoms have resolved. […] Repeat screening is recommended three months post-treatment for all people with C. trachomatis infection.

• #35 Chlamydia | STI Guidelines Australia

  https://sti.guidelines.org.au/sexually-transmissible-infections/chlamydia/

  For symptomatic anorectal infection, see testing and treatment recommendations. […] Advise no sexual contact for 7 days after treatment is commenced, or until the course is completed and symptoms resolved, whichever is later. […] Test of cure by nucleic acid amplification test (NAAT) in these situations should be performed no earlier than 4 weeks after treatment is completed to prevent false positive result due to persistent chlamydia DNA. […] Re-testing at 3 months is recommended to detect re-infection. […] 100% of patients diagnosed with chlamydia are treated with an appropriate antibiotic regimen.

• #36 Chlamydia

  https://www.health.wa.gov.au/Silver-book/Notifiable-infections/Chlamydia

  To ensure continuity of care, record follow-up instructions in the patient’s medical record. […] Consider the need to review symptomatic patients in approximately one week. This is an opportunity for further education and counselling. […] As NAAT can remain positive for three to four weeks after treatment, repeat sampling to exclude re-infection should be undertaken if possible at least one month after treatment in the following circumstances: Where regimens other than azithromycin or doxycycline are used […] In children […] In pregnant women […] Where there is doubt about compliance with treatment and advice […] Where symptoms persist […] Where there appear to be complicated infections such as PID or epididymitis […] Where there is a high risk of re-infection. […] Reasonable steps should be made to review patients three months after exposure as this provides an opportunity to test for reinfection and repeat blood tests for syphilis, HIV and HBV.

• #37 Chlamydia (Chlamydial Genitourinary Infections) Treatment & Management: Approach Considerations, Antibiotic Therapy, Prevention

  https://emedicine.medscape.com/article/214823-treatment

  Azithromycin also has been shown to be effective in the treatment of nongonococcal urethritis, whether related to C trachomatis, genital mycoplasmas, or other organisms. […] Lower genital infections caused by Chlamydia can be treated with single-dose, directly observed treatment. […] Treatment also is indicated for sexual partners of the index case if the time of the last sexual encounter was within 60 days of onset, and it should be considered for longer periods for the last sexual partner. […] Guidelines from the CDC recommend azithromycin 1 g orally as a single dose. Alternatives include amoxicillin 500 mg orally three times a day for 7 days as the preferred drug regimens for treating chlamydial infections in pregnancy. […] Test-of-cure to document chlamydial eradication (preferably via NAAT) 3-4 weeks after therapy completion is recommended.

• #38 Chlamydia Treatment Online | Doctorsa

  https://doctorsa.com/chlamydia-treatment-online/

  After receiving treatment for Chlamydia, you might still test positive for a few weeks. This happens because the test used (called NAAT, or nucleic acid amplification test) is very sensitive and can detect genetic material from dead bacteria, which can give a false positive result. Its usually recommended to retest three months after treatment to make sure youre not reinfected, especially if you have risk factors like a new or untreated sexual partner. […] Chlamydia is a common sexually transmitted infection (STI) that often doesnt cause noticeable symptoms, which is why many people may be unaware they have it. When symptoms do occur, they can include abnormal vaginal discharge that may be yellow or cloudy, pain during intercourse, and a burning sensation while urinating. Some women may also experience lower abdominal pain or bleeding between periods. Men might notice discharge from the penis, discomfort when urinating, or testicular pain. Because chlamydia can lead to serious complications if left untreated, such as infertility, its crucial to get tested and treated promptly if you suspect you might have it or if you are sexually active and at risk.

• #39 Chlamydia trachomatis – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/chlamydia/diagnosis-treatment/drc-20355355

  Chlamydia trachomatis is treated with antibiotics. You will likely need to take a medicine for seven days, or you may be given a one-time dose of a medicine. […] In most cases, the infection clears up within 1 to 2 weeks after you take the antibiotic. But you can still spread the infection at first. So avoid sexual activity from when you start treatment until all your symptoms are gone. […] Your sexual partner or partners from the last 60 days also need screening and treatment even if they don’t have symptoms. Otherwise, the infection can be passed back and forth between sexual partners. Make sure to avoid sexual contact until all exposed partners are treated. […] Three months after treatment, the Centers for Disease Control and Prevention recommends getting tested for chlamydia again. This is to make sure people haven’t been reinfected with the bacteria, which can happen if sex partners aren’t treated, or new sex partners have the bacteria.

• #40 Chlamydia: Symptoms (Men & Women), Diagnosis, Treatment

  https://www.webmd.com/sexual-conditions/chlamydia

  Chlamydia is curable. Because its a bacterial infection, doctors can treat it with antibiotics. If you have chlamydia, your doctor will prescribe oral antibiotics, such as azithromycin (Zithromax) or doxycycline. […] With treatment, your infection should clear up in about a week or two. Its important to finish all of your antibiotics, even if you feel better. […] If you have a vagina and your chlamydia infection is severe, you may need treatment in a hospital, IV antibiotics (medicine given through a vein), and pain medicine. […] Its important for your partner(s) to get treated as well, so you can avoid getting infected again and prevent spreading the infection to others. […] After you finish the antibiotics, you should get retested after 3 months to be sure the infection is cured. This is particularly important if you arent sure your partner(s) were treated. But do get tested even if your partner(s) were treated.

• #41 Chlamydia (Chlamydial Genitourinary Infections) Treatment & Management: Approach Considerations, Antibiotic Therapy, Prevention

  https://emedicine.medscape.com/article/214823-treatment

  There are recommendations on retesting because our retesting rates remain low and reminding people that after chlamydia, gonorrhea, and trichomonas, a 3-month test post-therapy is recommended due to the high incidence of reinfection. […] Patients should abstain from sexual intercourse for 7 days after single-dose therapy or until the end of a longer regimen.

• #42 Chlamydia and LGV guide: Key information and resources – Canada.ca

  https://www.canada.ca/en/public-health/services/infectious-diseases/sexual-health-sexually-transmitted-infections/canadian-guidelines/chlamydia-lgv.html

  LGV: Doxycycline 100 mg PO BID for 21 days. […] Test of cure (TOC) is recommended three weeks after completion of treatment when compliance to treatment is suboptimal, an alternative treatment regimen is used or the person is prepubertal or pregnant. […] LGV: TOC is recommended three weeks after completion of treatment. Follow people until TOC for chlamydia is negative and symptoms have resolved. […] Repeat screening is recommended three months post-treatment for all people with C. trachomatis infection.

• #43 Chlamydia trachomatis – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/chlamydia/diagnosis-treatment/drc-20355355

  Chlamydia trachomatis is treated with antibiotics. You will likely need to take a medicine for seven days, or you may be given a one-time dose of a medicine. […] In most cases, the infection clears up within 1 to 2 weeks after you take the antibiotic. But you can still spread the infection at first. So avoid sexual activity from when you start treatment until all your symptoms are gone. […] Your sexual partner or partners from the last 60 days also need screening and treatment even if they don’t have symptoms. Otherwise, the infection can be passed back and forth between sexual partners. Make sure to avoid sexual contact until all exposed partners are treated. […] Three months after treatment, the Centers for Disease Control and Prevention recommends getting tested for chlamydia again. This is to make sure people haven’t been reinfected with the bacteria, which can happen if sex partners aren’t treated, or new sex partners have the bacteria.

• #44 Chlamydia treatment — Chelsea and Westminster Hospital NHS Foundation Trust

  https://www.chelwest.nhs.uk/services/hiv-sexual-health/chlamydia-treatment

  Chlamydia treatment is straightforward and has a success rate of 95% or more. […] An infected person will usually receive a single dose of an antibiotic. In some instances (eg in men with testicular pain or women with pelvic pain) a longer course of antibiotics may be warranted. […] If you test positive you may be asked to return to clinic for treatment. However in some instances you may be given chlamydia treatment on the day of your test, ie without waiting for your results. […] If you have been infected with chlamydia it is possible you may also have another STI. Therefore it is advisable that you have a full sexual health screen for gonorrhoea, syphilis and HIV. […] If you are pregnant, you may be asked to return following treatment to make sure the chlamydial infection has been eradicated.

• #45 Chlamydia – treatment, symptoms and statistics | healthdirect

  https://www.healthdirect.gov.au/chlamydia

  Chlamydia is a sexually transmitted infection (STI) that usually spreads through unprotected sex. […] Once diagnosed, chlamydia is easy to treat with antibiotics. […] Chlamydia is treated with antibiotics such as doxycycline or azithromycin. Usually, one dose is needed. If you develop a secondary infection, you may need to take antibiotics for longer. […] Your sexual partners will also need to be treated. If you are worried they will not seek treatment themselves, you can get them an antibiotics prescription yourself. This is called patient delivered partner therapy (PDPT). […] You are also recommended to avoid sex, even with a condom, until 7 days after you have started antibiotics, or until you have finished treatment and symptoms have gone whichever is later. […] Test again for chlamydia 3 months after you have finished treatment, to make sure you have not been reinfected. […] Remember, after you finish your treatment, you are not immune to chlamydia. You can catch it again.

• #46

  https://portal.311.nyc.gov/article/?kanumber=KA-02626

  Doctors and nurses who diagnose chlamydia in a patient may legally prescribe or provide antibiotic drugs to the patient’s sex partners without first examining them. […] This medical practice is known as Expedited Partner Therapy (EPT) and the purpose is to decrease the spread of this sexually transmitted infection. […] If a sex partner brings you medicine to treat chlamydia, you should take it immediately, according to the Department of Health. After you take the medicine, you should not have any kind of sex for at least seven days. You should also get tested for sexually transmitted infections. […] According to the Department of Health, the medically accepted prescription for the treatment of chlamydia is Azithromycin, also called Zithromax or Zmax.

• #47 Chlamydia: Symptoms, Treatments, Causes, and More

  https://www.healthline.com/health/std/chlamydia

  Chlamydia treatment is easy and can be cured. Since it’s bacterial in nature, antibiotics treat it. […] Azithromycin is an antibiotic usually prescribed in a single, large dose. Doxycycline is an antibiotic that must be taken twice per day for about 1 week. […] A healthcare professional may also prescribe other antibiotics. No matter which antibiotic is prescribed, dosage instructions should be followed carefully to make sure the infection clears up fully. This can take up to 2 weeks, even with the single-dose medications. […] During the treatment time, it’s important not to have sex. It’s still possible to transmit and contract chlamydia if exposed again, even if you’ve treated a previous infection.

• #48 Chlamydia trachomatis – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/chlamydia/diagnosis-treatment/drc-20355355

  Chlamydia trachomatis is treated with antibiotics. You will likely need to take a medicine for seven days, or you may be given a one-time dose of a medicine. […] In most cases, the infection clears up within 1 to 2 weeks after you take the antibiotic. But you can still spread the infection at first. So avoid sexual activity from when you start treatment until all your symptoms are gone. […] Your sexual partner or partners from the last 60 days also need screening and treatment even if they don’t have symptoms. Otherwise, the infection can be passed back and forth between sexual partners. Make sure to avoid sexual contact until all exposed partners are treated. […] Three months after treatment, the Centers for Disease Control and Prevention recommends getting tested for chlamydia again. This is to make sure people haven’t been reinfected with the bacteria, which can happen if sex partners aren’t treated, or new sex partners have the bacteria.

• #49 Chlamydia treatment — Chelsea and Westminster Hospital NHS Foundation Trust

  https://www.chelwest.nhs.uk/services/hiv-sexual-health/chlamydia-treatment

  In women using the combined contraceptive pill or patch, the antibiotics used in your chlamydia treatment may temporarily reduce the effectiveness of your contraception. […] After you have begun your course of chlamydia treatment, you should start to notice an improvement in your symptoms within a few days. Generally, most symptoms should resolve completely within 24 weeks. […] If you are diagnosed with chlamydia you may need to inform anyone you have had sex with within the last six months as they may also be infected. […] You should not have oral, anal or vaginal sex during your course of chlamydia treatment or for seven days after a single dose of chlamydia treatment and also until your current partner completes their treatment and until both you and your partners symptoms have abated.

• #50 Different options for chlamydia treatment – STDcenterNY

  https://stdcenterny.com/chlamydia-treatment.html

  This treatment is called expedited partner therapy (EPT). It is treatment that a sexual partner of an infected person can get without seeing a doctor or being getting tested. […] First-line medications have demonstrated satisfying results. According to the CDC, azithromycin has been shown to be effective in 97% of people with urogenital infection, and doxycycline has a 98% efficacy rate. […] Symptoms tend to resolve quite quickly. Pain and burning during urination resolve within a few days to a week and other symptoms, such as pelvic pain and pain in the testicles, may resolve within two weeks. […] It is crucial to strictly avoid sexual contact for seven days after finishing the treatment, regardless of the treatment regimen. […] Yes. In 2006, the CDC approved expedited partner therapy (EPT). This therapy was designed for sexual partners of chlamydia-positive persons.

• #51 Chlamydia: Symptoms (Men & Women), Diagnosis, Treatment

  https://www.webmd.com/sexual-conditions/chlamydia

  Chlamydia is curable. Because its a bacterial infection, doctors can treat it with antibiotics. If you have chlamydia, your doctor will prescribe oral antibiotics, such as azithromycin (Zithromax) or doxycycline. […] With treatment, your infection should clear up in about a week or two. Its important to finish all of your antibiotics, even if you feel better. […] If you have a vagina and your chlamydia infection is severe, you may need treatment in a hospital, IV antibiotics (medicine given through a vein), and pain medicine. […] Its important for your partner(s) to get treated as well, so you can avoid getting infected again and prevent spreading the infection to others. […] After you finish the antibiotics, you should get retested after 3 months to be sure the infection is cured. This is particularly important if you arent sure your partner(s) were treated. But do get tested even if your partner(s) were treated.

• #52 Chlamydia: Causes, Symptoms, Treatment & Prevention

  https://my.clevelandclinic.org/health/diseases/4023-chlamydia

  Chlamydia infections are treatable and curable. However, its symptoms are often unnoticeable. Its important to receive treatment for chlamydia as soon as possible. Left untreated, chlamydia can lead to serious complications and cause permanent damage to your reproductive organs. […] Chlamydia can be cleared up with antibiotics in about a week or two. But dont stop taking your medication just because your symptoms improve. […] The most common antibiotics used to treat chlamydia infections are: Doxycycline. Usually taken over seven days, is preferred. Azithromycin. Usually taken as a single dose, is recommended as the first choice in pregnancy. […] Yes. Chlamydia can be treated and cured. Some sexually transmitted bacterial infections are starting to become resistant to antibiotics, though, and this makes them harder to treat.

• #53 Chlamydia: Diagnosis, Tests, Treatment, Medication

  https://www.webmd.com/sexual-conditions/understanding-chlamydia-treatment

  Chlamydia can be well treated with antibiotics and is cured in 95% of uncomplicated cases. […] Chlamydia is an STD that can only be cured with treatment. It wont go away on its own. If you dont get the right treatment, chlamydia can lead to serious issues such as fertility issues or arthritis. […] If you are diagnosed with chlamydia, your doctor will prescribe antibiotics that you take by mouth. […] Chlamydia is well treated with antibiotics. These antibiotics include: Azithromycin, a single dose of 1 gram; Doxycycline, 100 milligrams twice a day for 7 days; Tetracycline, 500 milligrams four times a day for 7 days; Erythromycin, 500 milligrams twice a day for 7 days; Ofloxacin, 200-400 milligrams twice a day for 7 days. […] Chlamydia cannot go away on its own, but treatment with antibiotics can cure it. Leaving chlamydia untreated can lead to serious and long-term health problems like: Increased risk of getting and spreading HIV; Fertility problems; Pelvic inflammatory disease (PID); Pre-term delivery; Ectopic pregnancy; Swollen joints (arthritis); Inflamed eyes; Stomach and pelvic pain.

• #54 Chlamydia: A Common and Curable Infection

  https://www.ashasexualhealth.org/chlamydia-101/

  Chlamydia can be treated and cured easily, but that doesnt mean that chlamydia infection isnt potentially dangerous. If chlamydia isnt diagnosed and left untreated, it can cause serious complications. […] Untreated chlamydia infections in women may lead to pelvic inflammatory disease (PID), a serious infection of the reproductive organs (uterus, fallopian tubes and ovaries). Left untreated, PID can cause infertility (and inability to become pregnant or maintain a pregnancy), chronic pelvic pain, or ectopic (tubal) pregnancy. […] Untreated chlamydia in men may lead to prostatitis (inflammation of the prostate gland), scarring of the urethra, infertility, and epididymitis (inflammation of the epididymis, which is the elongated, cord-like structure that runs along the back of each testes).

• #55 Chlamydia, Gonorrhea, and Syphilis | ACOG

  https://www.acog.org/womens-health/faqs/chlamydia-gonorrhea-and-syphilis

  Chlamydia is treated with an antibiotic. Your sex partners also need to be treated. This can often be done without them having to get tested (this is called expedited partner therapy) This includes anyone you have had sex with in the past 60 days or your last sex partner. Be sure to take all of your medicine as directed. […] You should be retested for chlamydia 3 months after treatment to be sure the infection is gone. If you cannot be retested 3 months after treatment, you should be retested at a health care visit within the next year. […] Untreated infection with chlamydia can lead to a condition called pelvic inflammatory disease (PID). This happens when bacteria move up from the vagina and cervix and into the uterus and fallopian tubes. Symptoms of PID may include chills, fever, and pelvic pain. Some people may not have symptoms until they have had PID for a while.

• #56 Chlamydia and treatment options: Frequently Asked Questions – Dr Fox

  https://www.doctorfox.co.uk/chlamydia/faqs.html?srsltid=AfmBOoor-LQwiJTguYnIEHerLJNehfw8Yi0lgQKgyUtJlixJ4UxyCPKX

  Chlamydia can still be passed on even when a man does not ejaculate. It is curable with doxycycline antibiotic. […] If left untreated chlamydia is unlikely to go away quickly. It can be passed onto sexual partners and can cause serious harm. Women can get cervicitis (inflammation of the cervix with bleeding, discharge and painful sex) or pelvic inflammatory disease. This can result in permanent damage to the fallopian tubes, which may lead to infertility or (life threatening) ectopic pregnancy. Men can suffer with urethritis (inflammation of the urethra: symptoms include discharge, pain passing urine, and sore skin at the penis tip), this can spread to the contents of the scrotal sac – epididymis and testicles (epididymo orchitis). This causes pain, and in severe cases infertility. Chlamydia can also cause reactive arthritis in men and women and inflammation around the liver (perihepatitis) in women.

• #57 Emerging Research Continues to Transform Chlamydia Treatment Market

  https://www.delveinsight.com/blog/chlamydia-treatment-outlook

  Chlamydia is the most common bacterial sexually transmitted infection across the world. […] Azithromycin has been considered the first-line treatment for chlamydia infection for many years. […] For chlamydia treatment, data from observational studies comparing azithromycin to doxycycline revealed that azithromycin had a greater chlamydia treatment failure rate than doxycycline. […] According to these revised guidelines, the recommended therapy for chlamydia treatment is now doxycycline 100 mg twice daily orally for 7 days. […] Besides doxycycline 100 mg twice daily for 7 days, other substitute regimens, either azithromycin 1 g orally in a single dose or levofloxacin 500 mg once daily for 7 days, are also recommended to subdue the development of antibiotic resistance. […] In general, erythromycin is regarded as a backup chlamydia medicine for those who are unable to follow another regimen.

• #58 Emerging Research Continues to Transform Chlamydia Treatment Market

  https://www.delveinsight.com/blog/chlamydia-treatment-outlook

  Chlamydia is one of the major bacterial pathogens that infect humans. Antibiotics are the only currently available chlamydia treatment option. […] Many key assets, including chlamydia vaccines, are at the preclinical stage of development. […] The major chlamydia companies such as Evofem Biosciences, QureTechBio, Vault Pharma, Aeterna Zentaris, Melinta Therapeutics, Abera Bioscience, Prokarium, Blue willow Biologics, Microbiotix, Abivax, and others are currently working to develop new drugs for chlamydia treatment which can be available in the chlamydia market in the upcoming years. […] The US Food and Drug Administration has granted Evofem Fast Track Designation to prevent chlamydia in women. […] The chlamydia medication is presently being tested in pivotal Phase III trials in women for urogenital chlamydia trachomatis and Neisseria gonorrhea infection.

• #59 University of Illinois Chicago

  https://dig.pharmacy.uic.edu/faqs/2022-2/january-2022-faqs/what-are-the-updated-treatment-recommendations-for-chlamydia-and-gonococcal-infections/

  The CDC recommendations for chlamydia and gonococcal infections in 2015 and 2021 are summarized in the Table. A key change is the removal of azithromycin as a recommended regimen for chlamydia as well as its removal in combination with ceftriaxone for gonococcal infections. […] For patients diagnosed with chlamydia, prompt treatment is warranted, and treatment of sexual partners is recommended. Recent evidence indicates that doxycycline is effective for urogenital, rectal, and oropharyngeal chlamydia infections, and it is now the preferred option to azithromycin. […] Although azithromycin continues to be sufficiently effective for urogenital chlamydial infections, it has been found to be less effective in rectal chlamydial infections. […] A 2021 systematic review in patients with rectal chlamydia found a higher microbiological cure rate with doxycycline than azithromycin.

• #60 Non-adherent treatment for chlamydia, gonorrhea common in primary care | CIDRAP

  https://www.cidrap.umn.edu/antimicrobial-stewardship/non-adherent-treatment-chlamydia-gonorrhea-common-primary-care

  A study yesterday in the Annals of Family Medicine indicates that many patients with chlamydia and gonorrhea infections aren’t receiving guideline-adherent treatment in primary care settings. […] Among those treated, only 14.0% of chlamydia and 38.7% of gonorrhea patients received the CDC-recommended first-line antibiotic. […] The authors of the study say the relatively large population of untreated chlamydia and gonorrhea infections is problematic because they could result in severe long-term health consequences for patients and contribute to ongoing transmission of the sexually transmitted infections (STIs). […] For all treated chlamydia infections, 14.0% of patients received doxycycline the CDC’s recommended treatment alone or with another antibiotic. Most chlamydia patients (83.9%) received azithromycin. For all treated gonorrhea infections, only 38.7% received CDC-recommended ceftriaxone alone or in combination with another antibiotic.

• #61 Non-adherent treatment for chlamydia, gonorrhea common in primary care | CIDRAP

  https://www.cidrap.umn.edu/antimicrobial-stewardship/non-adherent-treatment-chlamydia-gonorrhea-common-primary-care

  „Our findings, together with findings of higher rates of use of recommended regimens in sexually transmitted disease clinics reported in other studies, suggest that additional education and training may be needed for primary care clinicians to improve adherence,” they wrote. […] The authors say that while the findings point to the need for rapid diagnostic tests to reduce turnaround time, further research is needed to understand and address non-adherence to treatment guidelines and the barriers to timely treatment for certain groups. […] „Given the importance of timely treatment for these STIs to curb the spread of infection, there remains substantial opportunity to improve treatment rates across all patient groups, with particular attention directed to those in vulnerable populations,” the authors concluded. „Additional incentives may be needed to promote adherence to clinical practice guidelines and thereby ensure timely treatment and selection of the appropriate antibiotic regimen.”

• #62 Chlamydial and Gonococcal Infections: Screening, Diagnosis, and Treatment | AAFP

  https://www.aafp.org/pubs/afp/issues/2022/0400/p388.html

  Preferred chlamydia treatment is a seven-day course of doxycycline, 100 mg taken by mouth twice per day. […] Doxycycline should be used to treat chlamydia in nonpregnant people. […] Although spontaneous clearance of chlamydial infections is possible, people with positive test results should always be treated. […] The recommended treatment for non-pregnant people is now doxycycline, 100 mg, twice per day for seven days. […] Treatment regimens are reviewed in Table 7. […] If symptoms do not resolve or a test is persistently positive in a situation in which reinfection seems unlikely, an infectious disease specialist and local health department should be consulted in case of possible antimicrobial resistance.

• #63 Chlamydia – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK537286/

  Chlamydia trachomatis is responsible for the greatest number of sexually transmitted infections and the majority of infection-related of blindness worldwide. […] This activity reviews the evaluation and management of Chlamydia trachomatis infections and highlights the role of the interprofessional team in the care of affected patients. […] Describe the appropriate treatment of chlamydia trachomatis infections. […] Treatment for uncomplicated urogenital chlamydia infection is with azithromycin. Doxycycline is an alternative, but azithromycin is preferred as it is a single-dose therapy. Other alternatives include erythromycin, levofloxacin, and ofloxacin. […] The goal of treatment is the prevention of complications associated with infection (e.g., PID, infertility), to decrease the risk of transmission, and the resolution of symptoms.

• #64 Chlamydia – treatment, symptoms and statistics | healthdirect

  https://www.healthdirect.gov.au/chlamydia

  Chlamydia is a sexually transmitted infection (STI) that usually spreads through unprotected sex. […] Once diagnosed, chlamydia is easy to treat with antibiotics. […] Chlamydia is treated with antibiotics such as doxycycline or azithromycin. Usually, one dose is needed. If you develop a secondary infection, you may need to take antibiotics for longer. […] Your sexual partners will also need to be treated. If you are worried they will not seek treatment themselves, you can get them an antibiotics prescription yourself. This is called patient delivered partner therapy (PDPT). […] You are also recommended to avoid sex, even with a condom, until 7 days after you have started antibiotics, or until you have finished treatment and symptoms have gone whichever is later. […] Test again for chlamydia 3 months after you have finished treatment, to make sure you have not been reinfected. […] Remember, after you finish your treatment, you are not immune to chlamydia. You can catch it again.

• #65 Chlamydia Infections | Chlamydia | Chlamydia Symptoms | MedlinePlus

  https://medlineplus.gov/chlamydiainfections.html

  Chlamydia is a common sexually transmitted infection (STI). […] Antibiotics can cure it. […] Antibiotics will cure the infection. You may get a one-time dose of the antibiotics, or you may need to take medicine every day for 7 days. It is important to take all the medicine that your provider prescribed for you. […] It is common to get a repeat infection, so you need to get tested again about three months after treatment.

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