Blok gałęzi przedsionkowo-komorowych
Etiologia i przyczyny
Blok gałęzi przedsionkowo-komorowych (BBB) to zaburzenie przewodzenia impulsów elektrycznych w gałęziach pęczka Hisa, prowadzące do asynchronicznego skurczu komór i nieregularnego rytmu serca. Etiologia BBB jest zróżnicowana i obejmuje m.in. zawał mięśnia sercowego, nadciśnienie tętnicze, zapalenie mięśnia sercowego, kardiomiopatie, zator płucny oraz wrodzone wady serca. Blok lewej gałęzi pęczka Hisa (LBBB) najczęściej wiąże się z chorobami strukturalnymi serca, takimi jak choroba wieńcowa, przerost mięśnia sercowego czy choroby zastawkowe, a także z procesami degeneracyjnymi związanymi z wiekiem (np. choroba Leva, choroba Lenegre’a). LBBB jest rzadko spotykany u osób z prawidłową anatomią serca i zwykle wskazuje na poważne uszkodzenie układu przewodzącego, co wiąże się z gorszym rokowaniem.
Etiologia bloku gałęzi przedsionkowo-komorowych
Blok gałęzi przedsionkowo-komorowych (BBB) to stan, w którym dochodzi do częściowego lub całkowitego przerwania przewodzenia impulsów elektrycznych w jednej lub obu gałęziach pęczka Hisa. Zaburzenie to powoduje opóźnienie lub blokadę przewodzenia impulsów elektrycznych do komór serca, co skutkuje nieregularnym rytmem serca i asynchronicznym skurczem komór12. Przyczyny bloku gałęzi przedsionkowo-komorowych mogą być różne w zależności od tego, czy dotyczy on prawej, czy lewej gałęzi, a w niektórych przypadkach etiologia pozostaje nieznana3.
Ogólne przyczyny bloku gałęzi przedsionkowo-komorowych
Blok gałęzi przedsionkowo-komorowych może być wywołany wieloma czynnikami, które wpływają na układ przewodzący serca. Do najczęstszych ogólnych przyczyn należą45:
- Zawał mięśnia sercowego (myocardial infarction) – uszkodzenie tkanki sercowej podczas zawału może prowadzić do zaburzeń przewodnictwa
- Nadciśnienie tętnicze (hypertension) – długotrwałe nadciśnienie powoduje przebudowę strukturalną serca
- Zapalenie mięśnia sercowego (myocarditis) – stan zapalny może wpływać na układ przewodzący
- Kardiomiopatia (cardiomyopathy) – pogrubienie, sztywnienie lub osłabienie mięśnia sercowego zaburza przewodnictwo
- Zator płucny (pulmonary embolism) – może prowadzić do zwiększonego obciążenia prawej komory
- Wrodzone wady serca (congenital heart defects) – np. ubytek przegrody międzyprzedsionkowej
- Nadciśnienie płucne (pulmonary hypertension) – zwiększone ciśnienie w tętnicach płucnych
W około połowie przypadków, dokładna przyczyna bloku gałęzi przedsionkowo-komorowych pozostaje nieznana7. Warto zauważyć, że tkanka bliznowata, która może powstać po zawale serca lub w wyniku stanu zapalnego czy infekcji serca, może uszkodzić lewą lub prawą gałąź pęczka, prowadząc do nieprawidłowego rytmu serca8.
Etiologia bloku lewej gałęzi pęczka Hisa
Blok lewej gałęzi pęczka Hisa (LBBB) wynika z różnych czynników i stanów, które mogą wpływać na elektryczny układ przewodzący serca. Przyczyny można szeroko podzielić na kilka kategorii9:
Choroby strukturalne serca
Wśród strukturalnych chorób serca, które mogą prowadzić do LBBB, wyróżniamy1011:
- Choroba wieńcowa (CAD) – zwężenie naczyń wieńcowych może prowadzić do niedokrwienia i uszkodzenia układu przewodzącego
- Nadciśnienie tętnicze – długotrwałe nadciśnienie powoduje przerost mięśnia sercowego
- Kardiomiopatie – w tym kardiomiopatia rozstrzeniowa, niescalenie lewej komory, kardiomiopatia stresowa i przerostowa
- Choroby zastawki aortalnej – jak stenoza aortalna i niedomykalność
LBBB zwykle jest objawem istniejącej choroby serca i rzadko występuje u osób z prawidłową strukturą serca13. Jest to częściej spotykane u osób starszych i rzadko występuje u zdrowych, młodych osób14.
Zmiany degeneracyjne
LBBB może być również wynikiem zmian degeneracyjnych związanych z wiekiem, takich jak15:
- Zwłóknienie związane z wiekiem
- Choroba Leva – idiopatyczna, związana z wiekiem, postępująca choroba układu przewodzącego serca, charakteryzująca się rozległym zwapnieniem i zwłóknieniem szkieletu sercowego, w tym pierścienia zastawki aortalnej, pierścienia zastawki mitralnej i przegrody międzykomorowej
- Choroba Lenegre’a – związana z wiekiem, postępująca degeneracja włókien przewodzących, prowadząca do zwłóknienia i stwardnienia
Inne przyczyny LBBB
Do innych przyczyn bloku lewej gałęzi przedsionkowo-komorowej zaliczamy18:
- Choroby naciekowe – sarkoidoza lub amyloidoza
- Kardiomiopatie zapalne – zakaźne zapalenie mięśnia sercowego lub choroby autoimmunologiczne
- Jatrogennie – po operacjach kardiochirurgicznych obejmujących zastawkę aortalną lub przegrodę międzykomorową lub po przezcewnikowej wymianie zastawki aortalnej (TAVR)
- Zaburzenia elektrolitowe – hiperkaliemia
- Leki – leki przeciwarytmiczne
- Wrodzone wady strukturalne serca
- Idiopatyczne – szczególnie u młodszych pacjentów lub osób bez znaczących czynników ryzyka sercowo-naczyniowego
Warto zauważyć, że nowy LBBB w kontekście bólu w klatce piersiowej był kiedyś uważany za równoważnik zawału STEMI i część kryteriów do trombolizy. Jednak nowsze dane sugerują, że pacjenci z bólem w klatce piersiowej i nowym LBBB mają niewielkie zwiększone ryzyko ostrego zawału mięśnia sercowego w momencie prezentacji20.
Etiologia bloku prawej gałęzi pęczka Hisa
Blok prawej gałęzi pęczka Hisa (RBBB) może występować u osób bez innych objawów chorobowych, ale również może być związany z różnymi schorzeniami, szczególnie dotyczącymi prawej strony serca lub płuc21. W przeciwieństwie do LBBB, RBBB częściej występuje u osób starszych, choć może również pojawiać się u zdrowych, młodych osób22.
Choroby serca i płuc prowadzące do RBBB
RBBB może być sygnałem ostrzegawczym dla innych stanów, w tym2324:
- Zator płucny (pulmonary embolism) – najczęstsza przyczyna ostrego zwiększenia ciśnienia w prawej komorze
- Przewlekła choroba płuc (COPD)
- Kardiomiopatia – choroba mięśnia sercowego
- Wady przegrody międzyprzedsionkowej lub międzykomorowej
- Serce płucne (cor pulmonale) – przewlekłe zwiększenie ciśnienia w prawej komorze
- Zapalenie mięśnia sercowego (myocarditis) – infekcje mogą powodować bezpośrednie uszkodzenie komórkowe prawej gałęzi pęczka
- Zawał mięśnia sercowego – szczególnie zawał przedni, wskazujący na znaczne uszkodzenie mięśnia sercowego
Inne przyczyny RBBB
Inne czynniki, które mogą prowadzić do rozwoju RBBB, obejmują2728:
- Idiopatyczne zwłóknienie i zwapnienie układu przewodzącego – choroba Lenegre’a lub choroba Leva, najczęściej występuje u osób starszych
- Cewnikowanie prawej strony serca – RBBB może rozwinąć się tymczasowo podczas wprowadzania cewnika do prawej strony serca
- Urazy klatki piersiowej
- Zmiany strukturalne w prawej gałęzi – takie jak rozciąganie
- Hiperkaliemia – może zmieniać fizjologię przewodnictwa przez spowolnienie przewodzenia impulsów elektrycznych przez tkankę sercową
- Zespół Brugadów – związany z mutacjami w genie SCN5A, kodującym napięciowo-zależny kanał sodowy serca
U pacjentów z chorobą serca powodującą degenerację drogi przewodzącej może wystąpić blok gałęzi zależny od tachykardii31. Warto zauważyć, że niezupełny blok prawej gałęzi pęczka nie zwiększa ryzyka zawału serca i śmierci, w przeciwieństwie do pełnego RBBB32.
Rzadkie i specyficzne przyczyny RBBB
Istnieją również rzadkie i specyficzne przyczyny RBBB, które warto wymienić33:
- Tętniak gałęzi przegrodowej – może powodować bezpośredni nacisk na prawą gałąź pęczka w pobliżu jej przebiegu podwsierdziowego po prawej komorowej stronie przegrody międzykomorowej
- Ścięgno mięśniowe podzastawkowe – w lewej komorze, prowadzące do zwiększonej szybkości przewodzenia w lewej komorze, co skutkuje względnym RBBB
- Dziedziczny RBBB – obserwowany w czterech rodzinach libańskich i zmapowany na chromosomie 19
- RBBB wywołany wysiłkiem – rzadko obserwowany i wydaje się być łagodny
U dzieci, większość przypadków RBBB występuje po operacjach wewnątrzsercowych, takich jak operacje wrodzonych wad serca związane z naprawą ubytku przegrody międzykomorowej (VSD) i tetralogii Fallota, a także po przeszczepie serca36.
Blok obugałęziowy i trójgałęziowy
Blok obugałęziowy (bifascicular block) występuje, gdy dochodzi do opóźnienia przewodzenia w dwóch z trzech pęczków układu przewodzącego serca. Natomiast blok trójgałęziowy (trifascicular block) opisuje blok obugałęziowy połączony z blokiem przedsionkowo-komorowym pierwszego stopnia37.
Obecność bloku obugałęziowego lub trójgałęziowego po zawale mięśnia sercowego sugeruje rozległe uszkodzenie serca38. Masujący blok gałęzi pęczka (masquerading bundle branch block) to łatwo przeoczany wzór w EKG, który wskazuje na ciężką chorobę drogi przewodzącej węzła przedsionkowo-komorowego. Jest często spowodowany chorobą wieńcową, chorobami naciekowymi serca i idiopatyczną degeneracją dróg przewodzących węzła przedsionkowo-komorowego39.
Obecność tego specyficznego wzorca bloku gałęzi wskazuje na poważne zwłóknienie lewostronnych dróg pęczka i znacznie podwyższone ryzyko progresji do całkowitego rozkojarzenia przedsionkowo-komorowego40.
Czynniki genetyczne i styl życia
Istnieją dowody, że czynniki genetyczne mogą przyczyniać się do rozwoju bloku gałęzi przedsionkowo-komorowych. Pewne mutacje genów mogą zmieniać strukturę lub funkcję układu przewodzącego serca, prowadząc do nieprawidłowości elektrycznych41.
Określone czynniki stylu życia mogą zwiększać ryzyko rozwoju bloku gałęzi przedsionkowo-komorowych, takie jak palenie tytoniu i nadmierne spożycie alkoholu. Otyłość, nadciśnienie tętnicze i cukrzyca mogą również zwiększać ryzyko rozwoju chorób serca, co z kolei może prowadzić do bloku gałęzi przedsionkowo-komorowych42.
Podsumowanie etiologii bloku gałęzi przedsionkowo-komorowych
Blok gałęzi przedsionkowo-komorowych może mieć różne przyczyny, a rozpoznanie etiologii jest kluczowe dla odpowiedniego leczenia. Najczęstsze przyczyny to choroby strukturalne serca, degeneracyjne zmiany układu przewodzącego, zaburzenia elektrolitowe, leki oraz wrodzone wady serca43.
LBBB jest zwykle związany z podstawową chorobą serca i ma gorsze rokowanie niż RBBB. RBBB może wystąpić u osób bez choroby serca, ale również może być związany z chorobami prawej komory lub płuc44.
W przypadku niektórych pacjentów, zwłaszcza młodszych lub bez znaczących czynników ryzyka sercowo-naczyniowego, przyczyna bloku gałęzi może pozostać nieznana (idiopatyczna)45.
Zrozumienie przyczyn bloku gałęzi przedsionkowo-komorowych ma kluczowe znaczenie dla odpowiedniej strategii leczenia i profilaktyki powikłań sercowo-naczyniowych46.
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Materiały źródłowe
- #1 Bundle branch block – Symptoms & causes – Mayo Clinichttps://www.mayoclinic.org/diseases-conditions/bundle-branch-block/symptoms-causes/syc-20370514
Bundle branch block might not need treatment. When it does, treatment involves managing the underlying health condition, such as heart disease, that caused bundle branch block. […] If one or both of these branch bundles are damaged due to a heart attack, for example the electrical impulses can become blocked. As a result, the heart beats irregularly. […] The cause for bundle branch blocks can differ depending on whether the left or the right bundle branch is affected. Sometimes, there is no known cause. […] Causes can include: […] Heart attack (myocardial infarction) […] High blood pressure (hypertension) […] Inflammation of the heart muscle (myocarditis) […] Thickened, stiffened or weakened heart muscle (cardiomyopathy) […] Blood clot in the lungs (pulmonary embolism) […] Heart structure problems that are present at birth (congenital heart defects) such as a hole in the wall separating the upper chambers of the heart (atrial septal defect) […] High blood pressure in the pulmonary arteries (pulmonary hypertension).
- #2 Bundle branch block – Wikipediahttps://en.wikipedia.org/wiki/Bundle_branch_block
A bundle branch block is a partial or complete interruption in the flow of electrical impulses in either of the bundle branches of the heart’s electrical system. […] When a bundle branch or fascicle becomes injured (by underlying heart disease, myocardial infarction, or cardiac surgery), it may cease to conduct electrical impulses appropriately. […] Some people with bundle branch blocks are born with this condition. Many others acquire it as a consequence of heart disease.
- #3 Bundle branch block – Symptoms & causes – Mayo Clinichttps://www.mayoclinic.org/diseases-conditions/bundle-branch-block/symptoms-causes/syc-20370514
Bundle branch block might not need treatment. When it does, treatment involves managing the underlying health condition, such as heart disease, that caused bundle branch block. […] If one or both of these branch bundles are damaged due to a heart attack, for example the electrical impulses can become blocked. As a result, the heart beats irregularly. […] The cause for bundle branch blocks can differ depending on whether the left or the right bundle branch is affected. Sometimes, there is no known cause. […] Causes can include: […] Heart attack (myocardial infarction) […] High blood pressure (hypertension) […] Inflammation of the heart muscle (myocarditis) […] Thickened, stiffened or weakened heart muscle (cardiomyopathy) […] Blood clot in the lungs (pulmonary embolism) […] Heart structure problems that are present at birth (congenital heart defects) such as a hole in the wall separating the upper chambers of the heart (atrial septal defect) […] High blood pressure in the pulmonary arteries (pulmonary hypertension).
- #4 Bundle Branch Block: Causes, Symptoms & Treatmenthttps://my.clevelandclinic.org/health/diseases/22938-bundle-branch-block
A bundle branch block (BBB) is when something blocks or disrupts the electrical signal that causes your heart to beat. This block leads to an abnormal heart rhythm. […] Conditions that can cause a bundle branch block include: Congenital heart disease, Dilated cardiomyopathy, Heart attack (myocardial infarction), Heart disease (coronary artery disease), Heart failure, Heart infection (myocarditis), Heart valve disease, High blood pressure (hypertension), Hypertrophic cardiomyopathy, Weakened or stiffened heart muscle (cardiomyopathy). […] Right bundle branch block may also result from lung diseases including: Chronic obstructive pulmonary disease (COPD), Pulmonary embolism, Pulmonary hypertension (PH). […] Sometimes, a bundle branch block has no known cause. It can happen in people whose hearts otherwise function normally and who have no underlying conditions.
- #5 Bundle Branch Block > Fact Sheets > Yale Medicinehttps://www.yalemedicine.org/conditions/bundle-branch-block
A bundle branch block refers to a condition that arises from a blocked electrical pathway in the heart, causing the left and right sides of your heart to beat out of sync. […] Different conditions can cause a bundle branch block, including: High blood pressure (hypertension), Heart disease, Inflammation of the heart muscle (myocarditis), Heart-muscle disease (cardiomyopathy), Hardening of the arteries within the heart (arteriosclerosis), A blood clot that enters the lungs (pulmonary embolism), A congenital (or present at birth) heart abnormality. […] Its important to know that in about half of cases, the exact cause of a bundle branch block is unknown. […] Scar tissue, which can form after a heart attack or as a result of inflammation or an infection in the heart, may damage the left or right bundle branch, leading to an abnormal heart rhythm.
- #6 Bundle branch block – Symptoms & causes – Mayo Clinichttps://www.mayoclinic.org/diseases-conditions/bundle-branch-block/symptoms-causes/syc-20370514
Bundle branch block might not need treatment. When it does, treatment involves managing the underlying health condition, such as heart disease, that caused bundle branch block. […] If one or both of these branch bundles are damaged due to a heart attack, for example the electrical impulses can become blocked. As a result, the heart beats irregularly. […] The cause for bundle branch blocks can differ depending on whether the left or the right bundle branch is affected. Sometimes, there is no known cause. […] Causes can include: […] Heart attack (myocardial infarction) […] High blood pressure (hypertension) […] Inflammation of the heart muscle (myocarditis) […] Thickened, stiffened or weakened heart muscle (cardiomyopathy) […] Blood clot in the lungs (pulmonary embolism) […] Heart structure problems that are present at birth (congenital heart defects) such as a hole in the wall separating the upper chambers of the heart (atrial septal defect) […] High blood pressure in the pulmonary arteries (pulmonary hypertension).
- #7 Bundle Branch Block > Fact Sheets > Yale Medicinehttps://www.yalemedicine.org/conditions/bundle-branch-block
A bundle branch block refers to a condition that arises from a blocked electrical pathway in the heart, causing the left and right sides of your heart to beat out of sync. […] Different conditions can cause a bundle branch block, including: High blood pressure (hypertension), Heart disease, Inflammation of the heart muscle (myocarditis), Heart-muscle disease (cardiomyopathy), Hardening of the arteries within the heart (arteriosclerosis), A blood clot that enters the lungs (pulmonary embolism), A congenital (or present at birth) heart abnormality. […] Its important to know that in about half of cases, the exact cause of a bundle branch block is unknown. […] Scar tissue, which can form after a heart attack or as a result of inflammation or an infection in the heart, may damage the left or right bundle branch, leading to an abnormal heart rhythm.
- #8 Bundle Branch Block > Fact Sheets > Yale Medicinehttps://www.yalemedicine.org/conditions/bundle-branch-block
A bundle branch block refers to a condition that arises from a blocked electrical pathway in the heart, causing the left and right sides of your heart to beat out of sync. […] Different conditions can cause a bundle branch block, including: High blood pressure (hypertension), Heart disease, Inflammation of the heart muscle (myocarditis), Heart-muscle disease (cardiomyopathy), Hardening of the arteries within the heart (arteriosclerosis), A blood clot that enters the lungs (pulmonary embolism), A congenital (or present at birth) heart abnormality. […] Its important to know that in about half of cases, the exact cause of a bundle branch block is unknown. […] Scar tissue, which can form after a heart attack or as a result of inflammation or an infection in the heart, may damage the left or right bundle branch, leading to an abnormal heart rhythm.
- #9 Left Bundle Branch Block – StatPearls – NCBI Bookshelfhttps://www.ncbi.nlm.nih.gov/books/NBK482167/
LBBB arises from various factors and conditions that can affect the electrical conduction system. The underlying causes can be broadly categorized into structural heart disease, degenerative changes, and other less common factors. […] Structural heart disease: Coronary artery disease (CAD), hypertension, cardiomyopathies such as dilated, left ventricular noncompaction, stress, and hypertrophic cardiomyopathies, and aortic valve diseases like aortic stenosis and regurgitation. […] Degenerative changes: Age-related fibrosis, Lev disease, and Lengre disease. […] Lev disease is a form of idiopathic, age-related progressive cardiac conduction disorder characterized by extensive calcification and fibrosis of the cardiac skeleton, including the aortic valve annulus, mitral valve annulus, and interventricular septum.
- #10 Left Bundle Branch Block – StatPearls – NCBI Bookshelfhttps://www.ncbi.nlm.nih.gov/books/NBK482167/
LBBB arises from various factors and conditions that can affect the electrical conduction system. The underlying causes can be broadly categorized into structural heart disease, degenerative changes, and other less common factors. […] Structural heart disease: Coronary artery disease (CAD), hypertension, cardiomyopathies such as dilated, left ventricular noncompaction, stress, and hypertrophic cardiomyopathies, and aortic valve diseases like aortic stenosis and regurgitation. […] Degenerative changes: Age-related fibrosis, Lev disease, and Lengre disease. […] Lev disease is a form of idiopathic, age-related progressive cardiac conduction disorder characterized by extensive calcification and fibrosis of the cardiac skeleton, including the aortic valve annulus, mitral valve annulus, and interventricular septum.
- #11 Bundle Branch Block | Cedars-Sinaihttps://www.cedars-sinai.org/health-library/diseases-and-conditions/b/bundle-branch-block.html
A left bundle branch block usually is a sign of an underlying heart disease, including dilated cardiomyopathy, hypertrophic cardiomyopathy, high blood pressure, aortic valve disease, coronary artery disease and other heart conditions. While left bundle branch block can appear in healthy people, it most often does not.
- #12 Left Bundle Branch Block (LBBB) • LITFL • ECG Library Diagnosishttps://litfl.com/left-bundle-branch-block-lbbb-ecg-library/
Causes of Left Bundle Branch Block include: Aortic stenosis, Ischaemic heart disease, Hypertension, Dilated cardiomyopathy, Anterior MI, Lengre-Lev disease: primary degenerative disease (fibrosis) of the conducting system, Hyperkalaemia, Digoxin toxicity. […] It is unusual for LBBB to exist in the absence of organic disease. […] New LBBB in the context of chest pain was once considered a STEMI-equivalent and part of the criteria for thrombolysis. However, more up-to-date data suggests that chest pain patients with new LBBB have little increased risk of acute myocardial infarction at the time of presentation.
- #13 Bundle Branch Block | Cedars-Sinaihttps://www.cedars-sinai.org/health-library/diseases-and-conditions/b/bundle-branch-block.html
A left bundle branch block usually is a sign of an underlying heart disease, including dilated cardiomyopathy, hypertrophic cardiomyopathy, high blood pressure, aortic valve disease, coronary artery disease and other heart conditions. While left bundle branch block can appear in healthy people, it most often does not.
- #14 Left Bundle Branch Blockhttps://healthlibrary.brighamandwomens.org/library/Encyclopedia/134,551
Left bundle branch block can result from a number of heart conditions. These include: […] All of these conditions increase the risk for left bundle branch block. Sometimes, though, left bundle branch block happens on its own even when the heart may be structurally normal. Researchers arent sure what causes these cases of left bundle branch block, but they are more often seen in older people. […] Left bundle branch block happens more often in older people. It is rare in healthy young people. It usually happens in people who have some type of underlying heart problem.
- #15 Left Bundle Branch Block – StatPearls – NCBI Bookshelfhttps://www.ncbi.nlm.nih.gov/books/NBK482167/
LBBB arises from various factors and conditions that can affect the electrical conduction system. The underlying causes can be broadly categorized into structural heart disease, degenerative changes, and other less common factors. […] Structural heart disease: Coronary artery disease (CAD), hypertension, cardiomyopathies such as dilated, left ventricular noncompaction, stress, and hypertrophic cardiomyopathies, and aortic valve diseases like aortic stenosis and regurgitation. […] Degenerative changes: Age-related fibrosis, Lev disease, and Lengre disease. […] Lev disease is a form of idiopathic, age-related progressive cardiac conduction disorder characterized by extensive calcification and fibrosis of the cardiac skeleton, including the aortic valve annulus, mitral valve annulus, and interventricular septum.
- #16 Right Bundle Branch Block – StatPearls – NCBI Bookshelfhttps://www.ncbi.nlm.nih.gov/books/NBK507872/
Idiopathic fibrosis and calcification of the conduction system, called Lenegres disease or Levs disease, is a less common cause of right bundle branch block but most commonly occurs in the elderly. […] In patients with underlying heart disease causing degeneration of the conduction pathway, a tachycardia dependent bundle branch block can occur.
- #17 Right Bundle Branch Block (RBBB) • LITFL • ECG Library Diagnosishttps://litfl.com/right-bundle-branch-block-rbbb-ecg-library/
Causes of Right Bundle Branch Block include: Right ventricular hypertrophy / cor pulmonale […] Pulmonary embolus […] Ischaemic heart disease […] Rheumatic heart disease […] Congenital heart disease (e.g. atrial septal defect) […] Myocarditis […] Cardiomyopathy […] Lengre-Lev disease: primary degenerative disease (fibrosis) of the conducting system. […] There is increasing literature suggesting that in the context of chest pain, a new RBBB is highly concerning for OMI and a potential indication for immediate reperfusion therapy. The right bundle branch is supplied by LAD perforators in most patient populations and thus occlusion of this branch may manifest as a new RBBB +/- LAFB.
- #18 Left Bundle Branch Block – StatPearls – NCBI Bookshelfhttps://www.ncbi.nlm.nih.gov/books/NBK482167/
Lengre disease involves age-related, progressive degeneration of the conduction fibers, leading to fibrosis and sclerosis. […] Infiltrative conditions: sarcoidosis or amyloidosis. […] Inflammatory cardiomyopathies: Infectious myocarditis or autoimmune disease. […] Iatrogenic: Following cardiac surgery involving the aortic valve or interventricular septum or after transcatheter aortic valve replacement (TAVR). […] Electrolyte imbalance: Hyperkalemia. […] Medication: Anti-arrhythmic medications. […] Congenital structural heart disease. […] Idiopathic: Particularly in younger patients or individuals without significant cardiac risk factors.
- #19 Bundle Branch Blocks and Hemiblocks – EKG Essentials: A Student Handbookhttps://uark.pressbooks.pub/ekgmanual/chapter/bundle-branch-blocks-hemiblocks/
Bundle branch blocks and hemiblocks are conduction abnormalities that affect the hearts electrical system, specifically the bundle of His and its branches. […] A left bundle branch block (LBBB) occurs when conduction through the left bundle branch is impaired or blocked. […] The delay between the right and left ventricles creates distinctive M-shaped R waves in the lateral leads, a hallmark of LBBB. […] Because the delay makes impulses travel first through the right bundle branch to the right ventricle and then to the left ventricle through the septum, this reverses the normal septal activation direction and, thus, removes the lateral Q waves. […] Causes: Anterior MI, Coronary artery disease, Hypertension, Cardiomyopathy, Degenerative conduction system disease, Valvular heart disease, Hyperkalemia and digoxin toxicity.
- #20 Left Bundle Branch Block (LBBB) • LITFL • ECG Library Diagnosishttps://litfl.com/left-bundle-branch-block-lbbb-ecg-library/
Causes of Left Bundle Branch Block include: Aortic stenosis, Ischaemic heart disease, Hypertension, Dilated cardiomyopathy, Anterior MI, Lengre-Lev disease: primary degenerative disease (fibrosis) of the conducting system, Hyperkalaemia, Digoxin toxicity. […] It is unusual for LBBB to exist in the absence of organic disease. […] New LBBB in the context of chest pain was once considered a STEMI-equivalent and part of the criteria for thrombolysis. However, more up-to-date data suggests that chest pain patients with new LBBB have little increased risk of acute myocardial infarction at the time of presentation.
- #21 Bundle Branch Block | Cedars-Sinaihttps://www.cedars-sinai.org/health-library/diseases-and-conditions/b/bundle-branch-block.html
A block in the right bundle branch can occur in people who otherwise seem normal. If it happens with a heart attack, it can be a sign of serious heart muscle damage. […] Right bundle branch block happens more often in older people. It is rare in healthy young people. It may occur with natural degeneration of the hearts conduction system that occurs with age. It can also occur in people who have another underlying heart or lung problem. It may also be caused as a result of a heart procedure. […] A right bundle branch block only occurs in medical conditions that affect the right side of the heart or lungs. Finding a right bundle branch block is a signal to your doctor to look for other conditions, including: Blood clots in the lung, Chronic lung disease such as chronic obstructive pulmonary disorder, Disease of the heart muscle, known as cardiomyopathy, Defects of the wall between the upper chambers or lower chambers of the heart (atrial and ventricular septal defects).
- #22 Bundle Branch Block | Cedars-Sinaihttps://www.cedars-sinai.org/health-library/diseases-and-conditions/b/bundle-branch-block.html
A block in the right bundle branch can occur in people who otherwise seem normal. If it happens with a heart attack, it can be a sign of serious heart muscle damage. […] Right bundle branch block happens more often in older people. It is rare in healthy young people. It may occur with natural degeneration of the hearts conduction system that occurs with age. It can also occur in people who have another underlying heart or lung problem. It may also be caused as a result of a heart procedure. […] A right bundle branch block only occurs in medical conditions that affect the right side of the heart or lungs. Finding a right bundle branch block is a signal to your doctor to look for other conditions, including: Blood clots in the lung, Chronic lung disease such as chronic obstructive pulmonary disorder, Disease of the heart muscle, known as cardiomyopathy, Defects of the wall between the upper chambers or lower chambers of the heart (atrial and ventricular septal defects).
- #23 Bundle Branch Block | Cedars-Sinaihttps://www.cedars-sinai.org/health-library/diseases-and-conditions/b/bundle-branch-block.html
A block in the right bundle branch can occur in people who otherwise seem normal. If it happens with a heart attack, it can be a sign of serious heart muscle damage. […] Right bundle branch block happens more often in older people. It is rare in healthy young people. It may occur with natural degeneration of the hearts conduction system that occurs with age. It can also occur in people who have another underlying heart or lung problem. It may also be caused as a result of a heart procedure. […] A right bundle branch block only occurs in medical conditions that affect the right side of the heart or lungs. Finding a right bundle branch block is a signal to your doctor to look for other conditions, including: Blood clots in the lung, Chronic lung disease such as chronic obstructive pulmonary disorder, Disease of the heart muscle, known as cardiomyopathy, Defects of the wall between the upper chambers or lower chambers of the heart (atrial and ventricular septal defects).
- #24 Right Bundle Branch Block – StatPearls – NCBI Bookshelfhttps://www.ncbi.nlm.nih.gov/books/NBK507872/
Right bundle branch block is associated with structural changes from stretch or ischemia to the myocardium. […] A right bundle branch block is typically caused by disease processes that change the myocardium of the right bundle branch, for example, structural changes, trauma, and infiltrative processes. Rarely, hyperkalemia can alter the conduction physiology by slowing electrical impulse conduction through cardiac tissue, causing a right bundle branch block. […] Infections such as myocarditis or myocardial infarction can cause direct cellular damage to the right bundle branch. […] Increased right intraventricular pressure, either acutely by pulmonary embolism or chronically as in cor pulmonale, can stretch the right bundle branch causing a bundle branch block. […] RBBB can also be induced iatrogenically from right heart catheterizations and by ethanol ablation for a septal reduction in hypertrophic cardiomyopathy.
- #25 Bundle Branch Block: What to Knowhttps://www.webmd.com/heart-disease/bundle-branch-block
Impulses, or electrical signals, travel through both the left and right chambers of your heart to make it pump. But if the pathway is blocked, the impulses may move slower than normal or irregularly. This is called a bundle branch block. […] Your risk of having a bundle branch block goes up with age or if you have other health issues. […] If your cardiologist (a heart doctor) spots RBBB through a test called an electrocardiogram (EKG), they may look for underlying heart or lung conditions that could be causing the issue. […] These include: Pulmonary embolism (a blood clot in the lungs), Heart attack, Congenital heart defect (problems you were born with, like a hole in the wall between the upper chambers of the heart), High blood pressure in the arteries, Infection of the heart muscle (myocarditis).
- #26 Right Bundle Branch Block (RBBB) • LITFL • ECG Library Diagnosishttps://litfl.com/right-bundle-branch-block-rbbb-ecg-library/
Causes of Right Bundle Branch Block include: Right ventricular hypertrophy / cor pulmonale […] Pulmonary embolus […] Ischaemic heart disease […] Rheumatic heart disease […] Congenital heart disease (e.g. atrial septal defect) […] Myocarditis […] Cardiomyopathy […] Lengre-Lev disease: primary degenerative disease (fibrosis) of the conducting system. […] There is increasing literature suggesting that in the context of chest pain, a new RBBB is highly concerning for OMI and a potential indication for immediate reperfusion therapy. The right bundle branch is supplied by LAD perforators in most patient populations and thus occlusion of this branch may manifest as a new RBBB +/- LAFB.
- #27 Right Bundle Branch Block – StatPearls – NCBI Bookshelfhttps://www.ncbi.nlm.nih.gov/books/NBK507872/
Right bundle branch block is associated with structural changes from stretch or ischemia to the myocardium. […] A right bundle branch block is typically caused by disease processes that change the myocardium of the right bundle branch, for example, structural changes, trauma, and infiltrative processes. Rarely, hyperkalemia can alter the conduction physiology by slowing electrical impulse conduction through cardiac tissue, causing a right bundle branch block. […] Infections such as myocarditis or myocardial infarction can cause direct cellular damage to the right bundle branch. […] Increased right intraventricular pressure, either acutely by pulmonary embolism or chronically as in cor pulmonale, can stretch the right bundle branch causing a bundle branch block. […] RBBB can also be induced iatrogenically from right heart catheterizations and by ethanol ablation for a septal reduction in hypertrophic cardiomyopathy.
- #28 Right Bundle Branch Block: What Is It, Causes, Symptoms & Treatmenthttps://my.clevelandclinic.org/health/diseases/21692-right-bundle-branch-block
Right bundle branch block can be complete or incomplete. Unlike complete right bundle branch block, incomplete right bundle branch block doesnt increase your risk of heart attack and death. […] There are several causes of right bundle branch block, including: Myocarditis. Trauma to your chest. Heart attack (myocardial infarction). Right heart catheterization or other procedures. Changes in branch structure, such as stretching. Diseases (like Levs disease or Lenegres disease). […] If you have no symptoms and no heart disease, a right bundle branch block is not serious. But if youve already had heart failure or a heart attack along with right bundle branch block, it puts you at a higher risk of death.
- #29 Pediatric Right Bundle Branch Block: Background, Pathophysiology, Etiologyhttps://emedicine.medscape.com/article/894927-overview
Right bundle branch block (RBBB) occurs when transmission of the electrical impulse is delayed or not conducted along the right bundle branch. […] Right bundle branch block occurs when the electrical impulse from the bundle of His does not conduct along the right bundle branch. […] Exercise-induced right bundle branch block has been rarely noted and appears to be benign. […] Hereditary right bundle branch block (RBBB) was observed in four Lebanese families and has been mapped to chromosome 19. […] A subset of patients with Brugada syndrome have mutations in SCN5A, the gene that encodes for the voltage-gated cardiac sodium channel. […] In children, most cases of right bundle branch block occur after intracardiac surgery, such as congenital heart surgery associated with repair of a ventricular septal defect (VSD) and tetralogy of Fallot, as well as cardiac transplantation.
- #30 Right bundle branch block: Symptoms, treatment, and outlookhttps://www.medicalnewstoday.com/articles/right-bundle-branch-block
Right bundle branch block (RBBB) is a conduction abnormality affecting the electrical signals in the right ventricle of the heart. This causes a delay in the contraction of the right ventricle compared with the left ventricle. […] Several situations that lead to changes in the heart muscle or tissues may cause RBBB. These may include: […] Some people are born with congenital heart abnormalities. Others may experience certain conditions that cause structural changes to the heart that lead to RBBB development. […] Sometimes, physical injury, such as an impact to the chest, can cause changes that affect the heart and cause RBBB. […] This is the medical term for high potassium levels in the blood. In rare cases, it can affect the conduction of electrical impulses in the heart and cause RBBB.
- #31 Right Bundle Branch Block – StatPearls – NCBI Bookshelfhttps://www.ncbi.nlm.nih.gov/books/NBK507872/
Idiopathic fibrosis and calcification of the conduction system, called Lenegres disease or Levs disease, is a less common cause of right bundle branch block but most commonly occurs in the elderly. […] In patients with underlying heart disease causing degeneration of the conduction pathway, a tachycardia dependent bundle branch block can occur.
- #32 Right Bundle Branch Block: What Is It, Causes, Symptoms & Treatmenthttps://my.clevelandclinic.org/health/diseases/21692-right-bundle-branch-block
Right bundle branch block can be complete or incomplete. Unlike complete right bundle branch block, incomplete right bundle branch block doesnt increase your risk of heart attack and death. […] There are several causes of right bundle branch block, including: Myocarditis. Trauma to your chest. Heart attack (myocardial infarction). Right heart catheterization or other procedures. Changes in branch structure, such as stretching. Diseases (like Levs disease or Lenegres disease). […] If you have no symptoms and no heart disease, a right bundle branch block is not serious. But if youve already had heart failure or a heart attack along with right bundle branch block, it puts you at a higher risk of death.
- #33 Structural Causes of Right Bundle Branch BlockâTime for a Closer Look?https://opencardiovascularmedicinejournal.com/VOLUME/4/PAGE/105/
Right bundle branch block is an electrocardiographic phenomenon with specific criteria. […] A vast array of pathologies can cause proximal, distal or even combined forms of right bundle branch block. […] In this study it is suggested that a third type of right bundle branch block exist: one caused by a subaortic muscular tendon in the left ventricle, leading to an increased velocity of conduction in the left ventricle, with a resultant relative right bundle branch block. […] RBBB is the electrocardiographic reflection of delayed conduction in the right ventricle, caused by sclerosis (Lenegre`s disease), fibrosis (Lev`s disease) or necrosis of the right bundle branch. […] Recently, Shah et al. described a case of a septal branch aneurysm which caused a right bundle branch block by causing direct pressure on the right bundle branch near its subendocardial course on the right ventricular side of the interventricular septum.
- #34 Pediatric Right Bundle Branch Block: Background, Pathophysiology, Etiologyhttps://emedicine.medscape.com/article/894927-overview
Right bundle branch block (RBBB) occurs when transmission of the electrical impulse is delayed or not conducted along the right bundle branch. […] Right bundle branch block occurs when the electrical impulse from the bundle of His does not conduct along the right bundle branch. […] Exercise-induced right bundle branch block has been rarely noted and appears to be benign. […] Hereditary right bundle branch block (RBBB) was observed in four Lebanese families and has been mapped to chromosome 19. […] A subset of patients with Brugada syndrome have mutations in SCN5A, the gene that encodes for the voltage-gated cardiac sodium channel. […] In children, most cases of right bundle branch block occur after intracardiac surgery, such as congenital heart surgery associated with repair of a ventricular septal defect (VSD) and tetralogy of Fallot, as well as cardiac transplantation.
- #35 Structural Causes of Right Bundle Branch BlockâTime for a Closer Look?https://opencardiovascularmedicinejournal.com/VOLUME/4/PAGE/105/
In this study a third cause of RBBB is proposed neither proximal, nor distal, but one caused by increased conduction to the left ventricle by a subaortic muscular tendon in this way causing a pseudo RBBB. […] In this study, it is proposed that there exists a third type of right bundle branch block neither proximal, nor distal, but one caused by an increased velocity of conduction to the left ventricle, effected by a muscular sub-aortic tendon coursing between the sub-aortic portion of the interventricular septum and the apex of the left ventricle, in this way leading to a relative RBBB as conduction in the right ventricle lags behind the increased conduction in the left ventricle. […] Thus, in the assessment of structural causes for right bundle branch block it is suggested that it is time to take a closer look at endoventricular structures and specifically at muscular structures traversing the cavity of the left ventricle.
- #36 Pediatric Right Bundle Branch Block: Background, Pathophysiology, Etiologyhttps://emedicine.medscape.com/article/894927-overview
Right bundle branch block (RBBB) occurs when transmission of the electrical impulse is delayed or not conducted along the right bundle branch. […] Right bundle branch block occurs when the electrical impulse from the bundle of His does not conduct along the right bundle branch. […] Exercise-induced right bundle branch block has been rarely noted and appears to be benign. […] Hereditary right bundle branch block (RBBB) was observed in four Lebanese families and has been mapped to chromosome 19. […] A subset of patients with Brugada syndrome have mutations in SCN5A, the gene that encodes for the voltage-gated cardiac sodium channel. […] In children, most cases of right bundle branch block occur after intracardiac surgery, such as congenital heart surgery associated with repair of a ventricular septal defect (VSD) and tetralogy of Fallot, as well as cardiac transplantation.
- #37 Bundle Branch Blocks and Hemiblocks – EKG Essentials: A Student Handbookhttps://uark.pressbooks.pub/ekgmanual/chapter/bundle-branch-blocks-hemiblocks/
Causes: Often linked to coronary artery disease or MI, Conditions like cardiomyopathy can lead to left posterior hemiblock. […] A bifascicular block involves a conduction delay in two of the hearts three fascicles. […] A trifascicular block describes a bifascicular block combined with a first-degree AV block.
- #38 Bundle Branch Block and Fascicular Block – Cardiovascular Disorders – Merck Manual Professional Editionhttps://www.merckmanuals.com/professional/cardiovascular-disorders/specific-cardiac-arrhythmias/bundle-branch-block-and-fascicular-block
Presence of bifascicular or trifascicular block after myocardial infarction implies extensive cardiac damage. […] Nonspecific intraventricular conduction defects are diagnosed when the QRS complex is prolonged, but the QRS pattern is not typical of LBBB or RBBB. The conduction delay may occur beyond the Purkinje fibers and result from slow cell-to-cell myocyte conduction. Risk of subsequent cardiac events and mortality with nonspecific intraventricular conduction defect is similar to that of a LBBB.
- #39 Masquerading bundle branch block: an often missed electrophysiological event | BMJ Case Reportshttps://casereports.bmj.com/content/16/12/e254953
Masquerading bundle branch block is an easily overlooked pattern on the ECG that indicates severe disease of the atrioventricular nodal conduction pathway. It is often caused by coronary artery disease, infiltrative diseases of the heart and idiopathic degeneration of the atrioventricular nodal conduction pathways. […] The presence of a MBBB pattern on the electrocardiogram (ECG) indicates severe fibrotic degeneration of the left bundle pathways and a remarkably elevated risk of progression to complete atrioventricular dissociation. It is associated with high mortality (41.4%) and pacemaker insertion (38.9%), with combined endpoints of 80.2% over 4 years. […] MBBB is a mixed pattern of RBBB in precordial leads and LBBB in limb leads with qR or absent S waves in lead aVR or I. […] It is most commonly caused by ischaemic/coronary heart disease, cardiomyopathy, long-standing hypertension, Lenegre-Lev disease and Chagas myocarditis.
- #40 Masquerading bundle branch block: an often missed electrophysiological event | BMJ Case Reportshttps://casereports.bmj.com/content/16/12/e254953
The presence of this specific bundle branch block pattern indicates severe fibrosis of the left bundle pathways and a remarkably elevated risk of progression to complete atrioventricular dissociation than seen in the standard bifascicular block. […] Regardless of the presence or absence of trifascicular block, MBBB indicates significant degeneration of the conduction system, leading to a poor outcome.
- #41 Bundle Branch Block: Symptoms, Causes, Treatment | Qwarkhttps://qwarkhealth.com/conditions/bundle-branch-block
Bundle branch block can be caused by a heart attack, as well as other heart conditions, such as coronary artery disease, heart failure, and cardiomyopathy. A heart attack can cause damage to the heart muscles, which can disrupt the electrical signals that regulate the heart’s rhythm. […] There is evidence that genetic factors may contribute to the development of bundle branch block. Certain gene mutations may alter the structure or function of the heart’s conduction system, leading to electrical abnormalities in the heart. […] Certain lifestyle factors may increase the risk of developing bundle branch block, such as smoking and excessive alcohol consumption. Obesity, high blood pressure, and diabetes can also increase the risk of developing heart disease, which can in turn lead to bundle branch block.
- #42 Bundle Branch Block: Symptoms, Causes, Treatment | Qwarkhttps://qwarkhealth.com/conditions/bundle-branch-block
Bundle branch block can be caused by a heart attack, as well as other heart conditions, such as coronary artery disease, heart failure, and cardiomyopathy. A heart attack can cause damage to the heart muscles, which can disrupt the electrical signals that regulate the heart’s rhythm. […] There is evidence that genetic factors may contribute to the development of bundle branch block. Certain gene mutations may alter the structure or function of the heart’s conduction system, leading to electrical abnormalities in the heart. […] Certain lifestyle factors may increase the risk of developing bundle branch block, such as smoking and excessive alcohol consumption. Obesity, high blood pressure, and diabetes can also increase the risk of developing heart disease, which can in turn lead to bundle branch block.
- #43 Bundle Branch Blocks (LBBB, LAFB, RBBB, Trifascicular Block) : Emergency Care BChttps://emergencycarebc.ca/clinical_resource/clinical-summary/bundle-branch-blocks-lbbb-lafb-rbbb-trifascicular-block/
Bundle branch blocks can occur idiopathically as people age and the conduction system wears out, but can also be the result of infarction, ischemia, HTN, cardiomyopathies, endocarditis with abscess, etc. […] Heart blocks are often the result of degeneration of the conduction system over time, but in some cases can be secondary to neuromuscular conditions, ischemia or infarction or reversible causes.
- #44 ECG (EKG) – bundle branch block – Oxford Medical Educationhttps://oxfordmedicaleducation.com/ecgs/bundle-branch-block/
Right bundle branch block (RBBB) may indicate problems with the right side of the heart. […] Left bundle branch block (LBBB) is always pathological and relates to left heart disease. If acute it may indicate acute myocardial infarction and is one of the indications for thrombolysis or transfer for PCI. […] Causes of bundle branch blocks (BBBs) include ischaemic heart disease, hypertension, and myocarditis for LBBB, while RBBB can be normal in young, tall thin people, idiopathic, or due to right ventricular strain.
- #45 Left Bundle Branch Block – StatPearls – NCBI Bookshelfhttps://www.ncbi.nlm.nih.gov/books/NBK482167/
Lengre disease involves age-related, progressive degeneration of the conduction fibers, leading to fibrosis and sclerosis. […] Infiltrative conditions: sarcoidosis or amyloidosis. […] Inflammatory cardiomyopathies: Infectious myocarditis or autoimmune disease. […] Iatrogenic: Following cardiac surgery involving the aortic valve or interventricular septum or after transcatheter aortic valve replacement (TAVR). […] Electrolyte imbalance: Hyperkalemia. […] Medication: Anti-arrhythmic medications. […] Congenital structural heart disease. […] Idiopathic: Particularly in younger patients or individuals without significant cardiac risk factors.
- #46 Bundle Branch Block: Symptoms, Causes, Treatment | Qwarkhttps://qwarkhealth.com/conditions/bundle-branch-block
The prognosis can be different for left vs. right bundle branch block. Left bundle branch block is typically associated with a higher risk of complications, such as heart failure and sudden cardiac death, than right bundle branch block. […] Early detection and treatment of bundle branch block can potentially improve the prognosis. Treatment may include addressing underlying heart disease, managing symptoms, and using medications or other interventions to regulate heart rate and rhythm. […] Some preventative measures for Bundle Branch Block include regular exercise, maintaining a healthy diet, managing underlying medical conditions such as high blood pressure and diabetes, avoiding smoking and excessive alcohol consumption, and taking steps to reduce stress.