Materiały źródłowe

• #1 Development and Validation of a Prognostic Nomogram for Postoperative Recurrence-Free Survival of Ameloblastoma

  https://pmc.ncbi.nlm.nih.gov/articles/PMC8179736/

  Ameloblastoma is a benign odontogenic neoplasm with a high local recurrence rate if the operation is not thorough. […] This study aims to develop a prognostic nomogram model for ameloblastoma of the jaw to assist surgeons in surgical decision-making. […] Four independent predictors, including cortical bone perforation, root(s) resorption, WHO classification, and treatment pattern, were identified and included in the construction of a nomogram for recurrence-free survival (RFS), which showed promising calibration performance and discrimination in the training set (C-index 0.790, 95% confidence interval [CI] 0.7350.845) and the validation set (C-index 0.734, 95% CI 0.5990.869). […] A favorable nomogram was developed that accurately predicted the RFS of patients with ameloblastoma based on individual characteristics. Risk stratification using the nomogram could optimize tailored therapy and follow-up.

• #2 Development and Validation of a Prognostic Nomogram for Postoperative | CMAR

  https://www.dovepress.com/development-and-validation-of-a-prognostic-nomogram-for-postoperative–peer-reviewed-fulltext-article-CMAR

  Ameloblastoma is a benign odontogenic neoplasm with a high local recurrence rate if the operation is not thorough. […] This study aims to develop a prognostic nomogram model for ameloblastoma of the jaw to assist surgeons in surgical decision-making. […] Four independent predictors, including cortical bone perforation, root(s) resorption, WHO classification, and treatment pattern, were identified and included in the construction of a nomogram for recurrence-free survival (RFS), which showed promising calibration performance and discrimination in the training set (C-index 0.790, 95% confidence interval [CI] 0.735 0.845) and the validation set (C-index 0.734, 95% CI 0.599 0.869). […] A favorable nomogram was developed that accurately predicted the RFS of patients with ameloblastoma based on individual characteristics. Risk stratification using the nomogram could optimize tailored therapy and follow-up.

• #3 Prognostic and proliferative evaluation of ameloblastoma based on radiographic boundary | International Journal of Oral Science

  https://www.nature.com/articles/ijos20128

  Ameloblastoma is a benign odontogenic tumor with an aggressive biological behavior, and the surgical treatment frequently results in failure for the postoperative recurrence. […] The radiographic boundary could be used as one of indicators in evaluating the proliferative ability of ameloblastoma and the patient’s prognosis, which was consistent with Ki-67 expression. […] The prognosis of ameloblastoma was associated mainly with the method of surgical treatment, which meant that patients receiving a conservative treatment had a worse prognosis than those who received a radical one. […] Ameloblastomas with ill-defined boundary are thought to have the most aggressive behavior than others, which should be treated by the radical surgery because of the higher recurrent probability. […] We found that the Ki-67 LI of the ameloblastoma in group III was the highest among the three groups which could be attributed to the fact that ameloblastoma with ill-defined radiographic boundary contained more cells with higher proliferative ability. […] It means that we could use the radiographic boundary as a reference to the patients for choosing surgical plan, apart from the lesion size, location, patient age, clinical and pathological types, and other parameters, and avoid the overtreatment to make those patients get a better quality of life.

• #4 Development and Validation of a Prognostic Nomogram for Postoperative | CMAR

  https://www.dovepress.com/development-and-validation-of-a-prognostic-nomogram-for-postoperative–peer-reviewed-fulltext-article-CMAR

  The study results presented herein show that the 3-, 5- and 10-year RFS rates for ameloblastoma were 89.1%, 86.4% and 82.8%, respectively. […] Multivariate Cox analysis showed that root(s) resorption, cortical bone perforation, treatment pattern, and WHO classification were independent prognostic risk factors of ameloblastoma. […] To the best of our knowledge, this study is the first to construct a prognostic predictive nomogram model to quantitatively estimate the RFS for patients with ameloblastoma. […] In conclusion, the recurrence of ameloblastoma is significantly associated with cortical bone perforation, root(s) resorption, WHO classification, and treatment pattern. The study presented herein is the first to develop and use a nomogram to accurately predict the prognosis and RFS in patients with ameloblastoma following surgery.

• #5 Development and Validation of a Prognostic Nomogram for Postoperative Recurrence-Free Survival of Ameloblastoma

  https://pmc.ncbi.nlm.nih.gov/articles/PMC8179736/

  The study results presented herein show that the 3-, 5- and 10-year RFS rates for ameloblastoma were 89.1%, 86.4% and 82.8%, respectively. […] Multivariate Cox analysis showed that root(s) resorption, cortical bone perforation, treatment pattern, and WHO classification were independent prognostic risk factors of ameloblastoma. […] Therefore, our nomogram model may be applied clinically to create more tailored strategies to minimize and manage recurrence risk in patients with ameloblastoma. […] The recurrence of ameloblastoma is significantly associated with cortical bone perforation, root(s) resorption, WHO classification, and treatment pattern. The study presented herein is the first to develop and use a nomogram to accurately predict the prognosis and RFS in patients with ameloblastoma following surgery.

• #6 Classification and prognostic evaluation of ameloblastoma using multiplanar CT imaging: a retrospective analysis | BMC Oral Health | Full Text

  https://bmcoralhealth.biomedcentral.com/articles/10.1186/s12903-025-05485-6

  Ameloblastoma is the most prevalent odontogenic tumor of the jaw, with a significant recurrence rate. […] The recurrence rate was 14.11%, and the risk of recurrence was substantially reduced by mandibulectomy and a larger tumor size. […] An accurate diagnosis of ameloblastoma and surgical planning to reduce the recurrence rate are contingent upon the use of three-dimensional imaging modalities, such as CT. […] The recurrence was exclusively associated with the size and operation technique. […] A recurrence rate analysis found that larger lesions and more extensive surgical excision (as in mandibulectomy) were associated with lower recurrence rates. […] No direct correlation was found between the newly defined locularity types and recurrence rates.

• #7

  https://link.springer.com/article/10.1007/s44178-024-00145-1

  A weakened immune system and cellular aging may increase the risk of tumor metastasis and malignant transformation, including the metastasis of ameloblastoma to the orbit. […] Although ameloblastoma is essentially a benign tumor, in some cases, tumor cells may undergo genetic mutations, leading to malignant transformation. […] Malignantly transformed tumor cells have stronger invasiveness and metastatic potential, making them more prone to orbital metastasis. […] The treatment of OAM requires close collaboration between ophthalmology, oncology, radiology, and other disciplines. In the future, interdisciplinary teams will place greater emphasis on collaboration and communication, jointly formulating comprehensive treatment plans to improve treatment outcomes and patients’ quality of life.

• #8

  https://link.springer.com/article/10.1007/s44178-024-00145-1

  There are numerous types of orbital tumors, among which orbital ameloblastoma is a rare metastatic benign tumor that often originates in the jaw and later metastasizes to the orbit. […] The prognosis of orbital ameloblastoma is relatively poor, but there is still hope. With aggressive treatment and close follow-up observation, patients may still have the possibility of achieving a longer survival period and a better quality of life. […] Ameloblastoma has the potential for malignant transformation in cases of frequent recurrence, similar to confirmed malignant tumors. […] Therefore, it is clinically considered as a borderline tumor that requires close monitoring and aggressive treatment. […] The metastasis of ameloblastoma is relatively rare, with only 2% of cases experiencing metastasis, usually diagnosed after retrospective analysis.

• #9 Ameloblastoma – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK545165/

  Prognosis: Unfortunately, malignant ameloblastoma is too rare to estimate its prognosis. Due to its slow-growing nature, the malignancy may not occur for up to 10 years after initial resection of benign ameloblastoma. […] The complications of malignant ameloblastoma are usually due to its local invasiveness or distant metastatic spread. In terms of local complications, it can lead to progressive maxillary and mandibular distortion leading to deformity, pain, and malocclusion.

• #10

  https://link.springer.com/article/10.1007/s44178-024-00145-1

  There are numerous types of orbital tumors, among which orbital ameloblastoma is a rare metastatic benign tumor that often originates in the jaw and later metastasizes to the orbit. […] The prognosis of orbital ameloblastoma is relatively poor, but there is still hope. With aggressive treatment and close follow-up observation, patients may still have the possibility of achieving a longer survival period and a better quality of life. […] Ameloblastoma has the potential for malignant transformation in cases of frequent recurrence, similar to confirmed malignant tumors. […] Therefore, it is clinically considered as a borderline tumor that requires close monitoring and aggressive treatment. […] The metastasis of ameloblastoma is relatively rare, with only 2% of cases experiencing metastasis, usually diagnosed after retrospective analysis.

• #11

  https://link.springer.com/article/10.1007/s44178-024-00145-1

  A weakened immune system and cellular aging may increase the risk of tumor metastasis and malignant transformation, including the metastasis of ameloblastoma to the orbit. […] Although ameloblastoma is essentially a benign tumor, in some cases, tumor cells may undergo genetic mutations, leading to malignant transformation. […] Malignantly transformed tumor cells have stronger invasiveness and metastatic potential, making them more prone to orbital metastasis. […] The treatment of OAM requires close collaboration between ophthalmology, oncology, radiology, and other disciplines. In the future, interdisciplinary teams will place greater emphasis on collaboration and communication, jointly formulating comprehensive treatment plans to improve treatment outcomes and patients’ quality of life.

• #12 Development and Validation of a Prognostic Nomogram for Postoperative | CMAR

  https://www.dovepress.com/development-and-validation-of-a-prognostic-nomogram-for-postoperative–peer-reviewed-fulltext-article-CMAR

  The study results presented herein show that the 3-, 5- and 10-year RFS rates for ameloblastoma were 89.1%, 86.4% and 82.8%, respectively. […] Multivariate Cox analysis showed that root(s) resorption, cortical bone perforation, treatment pattern, and WHO classification were independent prognostic risk factors of ameloblastoma. […] To the best of our knowledge, this study is the first to construct a prognostic predictive nomogram model to quantitatively estimate the RFS for patients with ameloblastoma. […] In conclusion, the recurrence of ameloblastoma is significantly associated with cortical bone perforation, root(s) resorption, WHO classification, and treatment pattern. The study presented herein is the first to develop and use a nomogram to accurately predict the prognosis and RFS in patients with ameloblastoma following surgery.

• #13 Development and Validation of a Prognostic Nomogram for Postoperative Recurrence-Free Survival of Ameloblastoma

  https://pmc.ncbi.nlm.nih.gov/articles/PMC8179736/

  The study results presented herein show that the 3-, 5- and 10-year RFS rates for ameloblastoma were 89.1%, 86.4% and 82.8%, respectively. […] Multivariate Cox analysis showed that root(s) resorption, cortical bone perforation, treatment pattern, and WHO classification were independent prognostic risk factors of ameloblastoma. […] Therefore, our nomogram model may be applied clinically to create more tailored strategies to minimize and manage recurrence risk in patients with ameloblastoma. […] The recurrence of ameloblastoma is significantly associated with cortical bone perforation, root(s) resorption, WHO classification, and treatment pattern. The study presented herein is the first to develop and use a nomogram to accurately predict the prognosis and RFS in patients with ameloblastoma following surgery.

• #14 Prognostic and proliferative evaluation of ameloblastoma based on radiographic boundary | International Journal of Oral Science

  https://www.nature.com/articles/ijos20128

  Ameloblastoma is a benign odontogenic tumor with an aggressive biological behavior, and the surgical treatment frequently results in failure for the postoperative recurrence. […] The radiographic boundary could be used as one of indicators in evaluating the proliferative ability of ameloblastoma and the patient’s prognosis, which was consistent with Ki-67 expression. […] The prognosis of ameloblastoma was associated mainly with the method of surgical treatment, which meant that patients receiving a conservative treatment had a worse prognosis than those who received a radical one. […] Ameloblastomas with ill-defined boundary are thought to have the most aggressive behavior than others, which should be treated by the radical surgery because of the higher recurrent probability. […] We found that the Ki-67 LI of the ameloblastoma in group III was the highest among the three groups which could be attributed to the fact that ameloblastoma with ill-defined radiographic boundary contained more cells with higher proliferative ability. […] It means that we could use the radiographic boundary as a reference to the patients for choosing surgical plan, apart from the lesion size, location, patient age, clinical and pathological types, and other parameters, and avoid the overtreatment to make those patients get a better quality of life.

• #15 Prognostic and proliferative evaluation of ameloblastoma based on radiographic boundary | International Journal of Oral Science

  https://www.nature.com/articles/ijos20128

  Ameloblastoma is a benign odontogenic tumor with an aggressive biological behavior, and the surgical treatment frequently results in failure for the postoperative recurrence. […] The radiographic boundary could be used as one of indicators in evaluating the proliferative ability of ameloblastoma and the patient’s prognosis, which was consistent with Ki-67 expression. […] The prognosis of ameloblastoma was associated mainly with the method of surgical treatment, which meant that patients receiving a conservative treatment had a worse prognosis than those who received a radical one. […] Ameloblastomas with ill-defined boundary are thought to have the most aggressive behavior than others, which should be treated by the radical surgery because of the higher recurrent probability. […] We found that the Ki-67 LI of the ameloblastoma in group III was the highest among the three groups which could be attributed to the fact that ameloblastoma with ill-defined radiographic boundary contained more cells with higher proliferative ability. […] It means that we could use the radiographic boundary as a reference to the patients for choosing surgical plan, apart from the lesion size, location, patient age, clinical and pathological types, and other parameters, and avoid the overtreatment to make those patients get a better quality of life.

• #16

  https://link.springer.com/article/10.1007/s40615-024-01993-3

  Ameloblastomas are benign neoplasms of the jaw, but frequently require extensive surgery. […] The prognosis is often positive when treated early, an untreated ameloblastoma can lead to jaw damage, facial deformity, and even death due to complications from rare metastases, infection, and damage to critical structures in the head and neck. […] Data suggests a strong influence of racial factors on the incidence of ameloblastoma, with regards to size, Black patients with ameloblastoma trended higher and more data is needed to clearly elucidate any relationship between the tumor size and race, as other factors may influence the size (such as time to discovery). […] We found a statistically significant differences between the age of Black and White patients presenting with ameloblastomas. For ameloblastoma patients, the mean age of Black patients was 40.5 years and the mean age of White patients occurring at 47.8 years.

• #17

  https://link.springer.com/article/10.1007/s40615-024-01993-3

  Ameloblastomas are benign neoplasms of the jaw, but frequently require extensive surgery. […] The prognosis is often positive when treated early, an untreated ameloblastoma can lead to jaw damage, facial deformity, and even death due to complications from rare metastases, infection, and damage to critical structures in the head and neck. […] Data suggests a strong influence of racial factors on the incidence of ameloblastoma, with regards to size, Black patients with ameloblastoma trended higher and more data is needed to clearly elucidate any relationship between the tumor size and race, as other factors may influence the size (such as time to discovery). […] We found a statistically significant differences between the age of Black and White patients presenting with ameloblastomas. For ameloblastoma patients, the mean age of Black patients was 40.5 years and the mean age of White patients occurring at 47.8 years.

• #18

  https://link.springer.com/article/10.1007/s40615-024-01993-3

  While we did not find significance for size of ameloblastomas, the mean tumor size trended larger in the Black patients compared to the White patients. […] With respect to recurrence rate of 9 of the 129 total cases (7.0%), our rate is in agreement with the rate of 6.8% found in Nigeria where surgical resection was utilized as the primary treatment method. […] More data is needed to clearly elucidate any relationship between the tumor size and race, as factors such as time of discovery may impact the ultimate patient outcomes. […] In conclusion, we have shown the higher prevalence of ameloblastomas in Black patients within the southern United States over a ten-year period. Critically, we found significance between the age of Black and White patients, with Black patients presenting with ameloblastomas around 7 years earlier on average.

• #19 Prognostic and proliferative evaluation of ameloblastoma based on radiographic boundary | International Journal of Oral Science

  https://www.nature.com/articles/ijos20128

  Ameloblastoma is a benign odontogenic tumor with an aggressive biological behavior, and the surgical treatment frequently results in failure for the postoperative recurrence. […] The radiographic boundary could be used as one of indicators in evaluating the proliferative ability of ameloblastoma and the patient’s prognosis, which was consistent with Ki-67 expression. […] The prognosis of ameloblastoma was associated mainly with the method of surgical treatment, which meant that patients receiving a conservative treatment had a worse prognosis than those who received a radical one. […] Ameloblastomas with ill-defined boundary are thought to have the most aggressive behavior than others, which should be treated by the radical surgery because of the higher recurrent probability. […] We found that the Ki-67 LI of the ameloblastoma in group III was the highest among the three groups which could be attributed to the fact that ameloblastoma with ill-defined radiographic boundary contained more cells with higher proliferative ability. […] It means that we could use the radiographic boundary as a reference to the patients for choosing surgical plan, apart from the lesion size, location, patient age, clinical and pathological types, and other parameters, and avoid the overtreatment to make those patients get a better quality of life.

• #20 The Effect of Conservative vs. Radical Treatment of Ameloblastoma on Recurrence Rate and Quality of Life: An Umbrella Review

  https://www.mdpi.com/2077-0383/13/17/5339?type=check_update&version=1

  Ameloblastoma is a rare, benign, but locally aggressive odontogenic tumor that originates from the epithelial cells involved in tooth development. […] The primary outcome was the recurrence rate after surgical treatment, while the secondary outcomes were the post-operative complications, quality of life, esthetic, and functional impairment. […] The recurrence rate is about three-times more likely in the conservative treatment group compared to the radical treatment group, and this result is statistically significant. […] Despite the high recurrence rate, the latter was more appropriate in the case of smaller lesions and younger patients, due to better post-operative quality of life and reduced functional and esthetic impairments. […] Based on the results of this overview, conservative treatment may be recommended as the first-line approach for intraosseous ameloblastoma not involving soft tissue.

• #21 The Effect of Conservative vs. Radical Treatment of Ameloblastoma on Recurrence Rate and Quality of Life: An Umbrella Review

  https://www.mdpi.com/2077-0383/13/17/5339?type=check_update&version=1

  Ameloblastoma is a rare, benign, but locally aggressive odontogenic tumor that originates from the epithelial cells involved in tooth development. […] The primary outcome was the recurrence rate after surgical treatment, while the secondary outcomes were the post-operative complications, quality of life, esthetic, and functional impairment. […] The recurrence rate is about three-times more likely in the conservative treatment group compared to the radical treatment group, and this result is statistically significant. […] Despite the high recurrence rate, the latter was more appropriate in the case of smaller lesions and younger patients, due to better post-operative quality of life and reduced functional and esthetic impairments. […] Based on the results of this overview, conservative treatment may be recommended as the first-line approach for intraosseous ameloblastoma not involving soft tissue.

• #22 The Effect of Conservative vs. Radical Treatment of Ameloblastoma on Recurrence Rate and Quality of Life: An Umbrella Review

  https://www.mdpi.com/2077-0383/13/17/5339?type=check_update&version=1

  However, given the expectation of a higher recurrence rate, it is advisable to reduce the interval between follow-up visits. […] Most authors agreed that radical surgery, as marginal or segmental resection, was more appropriate in reducing the recurrence rate of both multicystic and unicystic ameloblastomas in comparison with conservative treatments. […] Conservative treatments, like enucleation, decompression, and marsupialization, were not considered as a definitive surgery, but they were useful only to lower the invasiveness of the second surgery. […] In Hendra et al. 2019, the pooled recurrence rate of solid/multicystic ameloblastomas following radical treatment was 8%, while conservative treatment caused recurrences in 41%. […] Similarly, Almeida et al. showed that the relative risk of recurrence was 3.15-fold greater when conservative treatment was performed on primary multicystic ameloblastoma in comparison to radical treatment.

• #23 The Effect of Conservative vs. Radical Treatment of Ameloblastoma on Recurrence Rate and Quality of Life: An Umbrella Review

  https://www.mdpi.com/2077-0383/13/17/5339?type=check_update&version=1

  However, given the expectation of a higher recurrence rate, it is advisable to reduce the interval between follow-up visits. […] Most authors agreed that radical surgery, as marginal or segmental resection, was more appropriate in reducing the recurrence rate of both multicystic and unicystic ameloblastomas in comparison with conservative treatments. […] Conservative treatments, like enucleation, decompression, and marsupialization, were not considered as a definitive surgery, but they were useful only to lower the invasiveness of the second surgery. […] In Hendra et al. 2019, the pooled recurrence rate of solid/multicystic ameloblastomas following radical treatment was 8%, while conservative treatment caused recurrences in 41%. […] Similarly, Almeida et al. showed that the relative risk of recurrence was 3.15-fold greater when conservative treatment was performed on primary multicystic ameloblastoma in comparison to radical treatment.

• #24 The Effect of Conservative vs. Radical Treatment of Ameloblastoma on Recurrence Rate and Quality of Life: An Umbrella Review

  https://www.mdpi.com/2077-0383/13/17/5339?type=check_update&version=1

  However, given the expectation of a higher recurrence rate, it is advisable to reduce the interval between follow-up visits. […] Most authors agreed that radical surgery, as marginal or segmental resection, was more appropriate in reducing the recurrence rate of both multicystic and unicystic ameloblastomas in comparison with conservative treatments. […] Conservative treatments, like enucleation, decompression, and marsupialization, were not considered as a definitive surgery, but they were useful only to lower the invasiveness of the second surgery. […] In Hendra et al. 2019, the pooled recurrence rate of solid/multicystic ameloblastomas following radical treatment was 8%, while conservative treatment caused recurrences in 41%. […] Similarly, Almeida et al. showed that the relative risk of recurrence was 3.15-fold greater when conservative treatment was performed on primary multicystic ameloblastoma in comparison to radical treatment.

• #25 The Effect of Conservative vs. Radical Treatment of Ameloblastoma on Recurrence Rate and Quality of Life: An Umbrella Review

  https://www.mdpi.com/2077-0383/13/17/5339?type=check_update&version=1

  However, given the expectation of a higher recurrence rate, it is advisable to reduce the interval between follow-up visits. […] Most authors agreed that radical surgery, as marginal or segmental resection, was more appropriate in reducing the recurrence rate of both multicystic and unicystic ameloblastomas in comparison with conservative treatments. […] Conservative treatments, like enucleation, decompression, and marsupialization, were not considered as a definitive surgery, but they were useful only to lower the invasiveness of the second surgery. […] In Hendra et al. 2019, the pooled recurrence rate of solid/multicystic ameloblastomas following radical treatment was 8%, while conservative treatment caused recurrences in 41%. […] Similarly, Almeida et al. showed that the relative risk of recurrence was 3.15-fold greater when conservative treatment was performed on primary multicystic ameloblastoma in comparison to radical treatment.

• #26 The Effect of Conservative vs. Radical Treatment of Ameloblastoma on Recurrence Rate and Quality of Life: An Umbrella Review

  https://www.mdpi.com/2077-0383/13/17/5339?type=check_update&version=1

  However, given the expectation of a higher recurrence rate, it is advisable to reduce the interval between follow-up visits. […] Most authors agreed that radical surgery, as marginal or segmental resection, was more appropriate in reducing the recurrence rate of both multicystic and unicystic ameloblastomas in comparison with conservative treatments. […] Conservative treatments, like enucleation, decompression, and marsupialization, were not considered as a definitive surgery, but they were useful only to lower the invasiveness of the second surgery. […] In Hendra et al. 2019, the pooled recurrence rate of solid/multicystic ameloblastomas following radical treatment was 8%, while conservative treatment caused recurrences in 41%. […] Similarly, Almeida et al. showed that the relative risk of recurrence was 3.15-fold greater when conservative treatment was performed on primary multicystic ameloblastoma in comparison to radical treatment.

• #27 The Effect of Conservative vs. Radical Treatment of Ameloblastoma on Recurrence Rate and Quality of Life: An Umbrella Review

  https://www.mdpi.com/2077-0383/13/17/5339

  Conservative treatments, like enucleation, decompression, and marsupialization, were not considered as a definitive surgery, but they were useful only to lower the invasiveness of the second surgery. […] The recurrence rate after the conservative surgery is neither comparable nor lower than the radical surgery (p = 0.28). […] The primary finding of this umbrella review is that radical treatments for ameloblastoma are associated with significantly lower recurrence rates compared to conservative treatments. […] For clinicians, this review underscores the importance of weighing the benefits of lower recurrence rates against the risks of adverse outcomes, including esthetic and functional impairments. […] Further prospective studies are needed to establish the best treatment choice and follow-up period.

• #28 Classification and prognostic evaluation of ameloblastoma using multiplanar CT imaging: a retrospective analysis | BMC Oral Health | Full Text

  https://bmcoralhealth.biomedcentral.com/articles/10.1186/s12903-025-05485-6

  Ameloblastoma is the most prevalent odontogenic tumor of the jaw, with a significant recurrence rate. […] The recurrence rate was 14.11%, and the risk of recurrence was substantially reduced by mandibulectomy and a larger tumor size. […] An accurate diagnosis of ameloblastoma and surgical planning to reduce the recurrence rate are contingent upon the use of three-dimensional imaging modalities, such as CT. […] The recurrence was exclusively associated with the size and operation technique. […] A recurrence rate analysis found that larger lesions and more extensive surgical excision (as in mandibulectomy) were associated with lower recurrence rates. […] No direct correlation was found between the newly defined locularity types and recurrence rates.

• #29 Classification and prognostic evaluation of ameloblastoma using multiplanar CT imaging: a retrospective analysis | BMC Oral Health | Full Text

  https://bmcoralhealth.biomedcentral.com/articles/10.1186/s12903-025-05485-6

  Ameloblastoma is the most prevalent odontogenic tumor of the jaw, with a significant recurrence rate. […] The recurrence rate was 14.11%, and the risk of recurrence was substantially reduced by mandibulectomy and a larger tumor size. […] An accurate diagnosis of ameloblastoma and surgical planning to reduce the recurrence rate are contingent upon the use of three-dimensional imaging modalities, such as CT. […] The recurrence was exclusively associated with the size and operation technique. […] A recurrence rate analysis found that larger lesions and more extensive surgical excision (as in mandibulectomy) were associated with lower recurrence rates. […] No direct correlation was found between the newly defined locularity types and recurrence rates.

• #30 Classification and prognostic evaluation of ameloblastoma using multiplanar CT imaging: a retrospective analysis | BMC Oral Health | Full Text

  https://bmcoralhealth.biomedcentral.com/articles/10.1186/s12903-025-05485-6

  Ameloblastoma is the most prevalent odontogenic tumor of the jaw, with a significant recurrence rate. […] The recurrence rate was 14.11%, and the risk of recurrence was substantially reduced by mandibulectomy and a larger tumor size. […] An accurate diagnosis of ameloblastoma and surgical planning to reduce the recurrence rate are contingent upon the use of three-dimensional imaging modalities, such as CT. […] The recurrence was exclusively associated with the size and operation technique. […] A recurrence rate analysis found that larger lesions and more extensive surgical excision (as in mandibulectomy) were associated with lower recurrence rates. […] No direct correlation was found between the newly defined locularity types and recurrence rates.

• #31 Classification and prognostic evaluation of ameloblastoma using multiplanar CT imaging: a retrospective analysis | BMC Oral Health | Full Text

  https://bmcoralhealth.biomedcentral.com/articles/10.1186/s12903-025-05485-6

  Ameloblastoma is the most prevalent odontogenic tumor of the jaw, with a significant recurrence rate. […] The recurrence rate was 14.11%, and the risk of recurrence was substantially reduced by mandibulectomy and a larger tumor size. […] An accurate diagnosis of ameloblastoma and surgical planning to reduce the recurrence rate are contingent upon the use of three-dimensional imaging modalities, such as CT. […] The recurrence was exclusively associated with the size and operation technique. […] A recurrence rate analysis found that larger lesions and more extensive surgical excision (as in mandibulectomy) were associated with lower recurrence rates. […] No direct correlation was found between the newly defined locularity types and recurrence rates.

• #32 Development and Validation of a Prognostic Nomogram for Postoperative Recurrence-Free Survival of Ameloblastoma

  https://pmc.ncbi.nlm.nih.gov/articles/PMC8179736/

  Ameloblastoma is a benign odontogenic neoplasm with a high local recurrence rate if the operation is not thorough. […] This study aims to develop a prognostic nomogram model for ameloblastoma of the jaw to assist surgeons in surgical decision-making. […] Four independent predictors, including cortical bone perforation, root(s) resorption, WHO classification, and treatment pattern, were identified and included in the construction of a nomogram for recurrence-free survival (RFS), which showed promising calibration performance and discrimination in the training set (C-index 0.790, 95% confidence interval [CI] 0.7350.845) and the validation set (C-index 0.734, 95% CI 0.5990.869). […] A favorable nomogram was developed that accurately predicted the RFS of patients with ameloblastoma based on individual characteristics. Risk stratification using the nomogram could optimize tailored therapy and follow-up.

• #33 Development and Validation of a Prognostic Nomogram for Postoperative | CMAR

  https://www.dovepress.com/development-and-validation-of-a-prognostic-nomogram-for-postoperative–peer-reviewed-fulltext-article-CMAR

  Ameloblastoma is a benign odontogenic neoplasm with a high local recurrence rate if the operation is not thorough. […] This study aims to develop a prognostic nomogram model for ameloblastoma of the jaw to assist surgeons in surgical decision-making. […] Four independent predictors, including cortical bone perforation, root(s) resorption, WHO classification, and treatment pattern, were identified and included in the construction of a nomogram for recurrence-free survival (RFS), which showed promising calibration performance and discrimination in the training set (C-index 0.790, 95% confidence interval [CI] 0.735 0.845) and the validation set (C-index 0.734, 95% CI 0.599 0.869). […] A favorable nomogram was developed that accurately predicted the RFS of patients with ameloblastoma based on individual characteristics. Risk stratification using the nomogram could optimize tailored therapy and follow-up.

• #34 Development and Validation of a Prognostic Nomogram for Postoperative Recurrence-Free Survival of Ameloblastoma

  https://pmc.ncbi.nlm.nih.gov/articles/PMC8179736/

  Ameloblastoma is a benign odontogenic neoplasm with a high local recurrence rate if the operation is not thorough. […] This study aims to develop a prognostic nomogram model for ameloblastoma of the jaw to assist surgeons in surgical decision-making. […] Four independent predictors, including cortical bone perforation, root(s) resorption, WHO classification, and treatment pattern, were identified and included in the construction of a nomogram for recurrence-free survival (RFS), which showed promising calibration performance and discrimination in the training set (C-index 0.790, 95% confidence interval [CI] 0.7350.845) and the validation set (C-index 0.734, 95% CI 0.5990.869). […] A favorable nomogram was developed that accurately predicted the RFS of patients with ameloblastoma based on individual characteristics. Risk stratification using the nomogram could optimize tailored therapy and follow-up.

• #35 Development and Validation of a Prognostic Nomogram for Postoperative | CMAR

  https://www.dovepress.com/development-and-validation-of-a-prognostic-nomogram-for-postoperative–peer-reviewed-fulltext-article-CMAR

  Ameloblastoma is a benign odontogenic neoplasm with a high local recurrence rate if the operation is not thorough. […] This study aims to develop a prognostic nomogram model for ameloblastoma of the jaw to assist surgeons in surgical decision-making. […] Four independent predictors, including cortical bone perforation, root(s) resorption, WHO classification, and treatment pattern, were identified and included in the construction of a nomogram for recurrence-free survival (RFS), which showed promising calibration performance and discrimination in the training set (C-index 0.790, 95% confidence interval [CI] 0.735 0.845) and the validation set (C-index 0.734, 95% CI 0.599 0.869). […] A favorable nomogram was developed that accurately predicted the RFS of patients with ameloblastoma based on individual characteristics. Risk stratification using the nomogram could optimize tailored therapy and follow-up.

• #36 Development and Validation of a Prognostic Nomogram for Postoperative | CMAR

  https://www.dovepress.com/development-and-validation-of-a-prognostic-nomogram-for-postoperative–peer-reviewed-fulltext-article-CMAR

  The study results presented herein show that the 3-, 5- and 10-year RFS rates for ameloblastoma were 89.1%, 86.4% and 82.8%, respectively. […] Multivariate Cox analysis showed that root(s) resorption, cortical bone perforation, treatment pattern, and WHO classification were independent prognostic risk factors of ameloblastoma. […] To the best of our knowledge, this study is the first to construct a prognostic predictive nomogram model to quantitatively estimate the RFS for patients with ameloblastoma. […] In conclusion, the recurrence of ameloblastoma is significantly associated with cortical bone perforation, root(s) resorption, WHO classification, and treatment pattern. The study presented herein is the first to develop and use a nomogram to accurately predict the prognosis and RFS in patients with ameloblastoma following surgery.

• #37 Development and Validation of a Prognostic Nomogram for Postoperative | CMAR

  https://www.dovepress.com/development-and-validation-of-a-prognostic-nomogram-for-postoperative–peer-reviewed-fulltext-article-CMAR

  The study results presented herein show that the 3-, 5- and 10-year RFS rates for ameloblastoma were 89.1%, 86.4% and 82.8%, respectively. […] Multivariate Cox analysis showed that root(s) resorption, cortical bone perforation, treatment pattern, and WHO classification were independent prognostic risk factors of ameloblastoma. […] To the best of our knowledge, this study is the first to construct a prognostic predictive nomogram model to quantitatively estimate the RFS for patients with ameloblastoma. […] In conclusion, the recurrence of ameloblastoma is significantly associated with cortical bone perforation, root(s) resorption, WHO classification, and treatment pattern. The study presented herein is the first to develop and use a nomogram to accurately predict the prognosis and RFS in patients with ameloblastoma following surgery.

• #38 Development and Validation of a Prognostic Nomogram for Postoperative Recurrence-Free Survival of Ameloblastoma

  https://pmc.ncbi.nlm.nih.gov/articles/PMC8179736/

  The study results presented herein show that the 3-, 5- and 10-year RFS rates for ameloblastoma were 89.1%, 86.4% and 82.8%, respectively. […] Multivariate Cox analysis showed that root(s) resorption, cortical bone perforation, treatment pattern, and WHO classification were independent prognostic risk factors of ameloblastoma. […] Therefore, our nomogram model may be applied clinically to create more tailored strategies to minimize and manage recurrence risk in patients with ameloblastoma. […] The recurrence of ameloblastoma is significantly associated with cortical bone perforation, root(s) resorption, WHO classification, and treatment pattern. The study presented herein is the first to develop and use a nomogram to accurately predict the prognosis and RFS in patients with ameloblastoma following surgery.

• #39

  https://link.springer.com/article/10.1007/s40615-024-01993-3

  Ameloblastomas are benign neoplasms of the jaw, but frequently require extensive surgery. […] The prognosis is often positive when treated early, an untreated ameloblastoma can lead to jaw damage, facial deformity, and even death due to complications from rare metastases, infection, and damage to critical structures in the head and neck. […] Data suggests a strong influence of racial factors on the incidence of ameloblastoma, with regards to size, Black patients with ameloblastoma trended higher and more data is needed to clearly elucidate any relationship between the tumor size and race, as other factors may influence the size (such as time to discovery). […] We found a statistically significant differences between the age of Black and White patients presenting with ameloblastomas. For ameloblastoma patients, the mean age of Black patients was 40.5 years and the mean age of White patients occurring at 47.8 years.

• #40

  https://link.springer.com/article/10.1007/s40615-024-01993-3

  Ameloblastomas are benign neoplasms of the jaw, but frequently require extensive surgery. […] The prognosis is often positive when treated early, an untreated ameloblastoma can lead to jaw damage, facial deformity, and even death due to complications from rare metastases, infection, and damage to critical structures in the head and neck. […] Data suggests a strong influence of racial factors on the incidence of ameloblastoma, with regards to size, Black patients with ameloblastoma trended higher and more data is needed to clearly elucidate any relationship between the tumor size and race, as other factors may influence the size (such as time to discovery). […] We found a statistically significant differences between the age of Black and White patients presenting with ameloblastomas. For ameloblastoma patients, the mean age of Black patients was 40.5 years and the mean age of White patients occurring at 47.8 years.

• #41 Ameloblastoma – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK545165/

  Prognosis: Unfortunately, malignant ameloblastoma is too rare to estimate its prognosis. Due to its slow-growing nature, the malignancy may not occur for up to 10 years after initial resection of benign ameloblastoma. […] The complications of malignant ameloblastoma are usually due to its local invasiveness or distant metastatic spread. In terms of local complications, it can lead to progressive maxillary and mandibular distortion leading to deformity, pain, and malocclusion.

• #42 The Effect of Conservative vs. Radical Treatment of Ameloblastoma on Recurrence Rate and Quality of Life: An Umbrella Review

  https://www.mdpi.com/2077-0383/13/17/5339

  Ameloblastoma is a rare, benign, but locally aggressive odontogenic tumor that originates from the epithelial cells involved in tooth development. […] The primary outcome was the recurrence rate after surgical treatment, while the secondary outcomes were the post-operative complications, quality of life, esthetic, and functional impairment. […] The quality of the included reviews ranged from critically low (three studies) to high (eight studies). […] The recurrence rate is about three-times more likely in the conservative treatment group compared to the radical treatment group, and this result is statistically significant. […] Despite the high recurrence rate, the latter was more appropriate in the case of smaller lesions and younger patients, due to better post-operative quality of life and reduced functional and esthetic impairments.

• #43 The Effect of Conservative vs. Radical Treatment of Ameloblastoma on Recurrence Rate and Quality of Life: An Umbrella Review

  https://www.mdpi.com/2077-0383/13/17/5339?type=check_update&version=1

  Ameloblastoma is a rare, benign, but locally aggressive odontogenic tumor that originates from the epithelial cells involved in tooth development. […] The primary outcome was the recurrence rate after surgical treatment, while the secondary outcomes were the post-operative complications, quality of life, esthetic, and functional impairment. […] The recurrence rate is about three-times more likely in the conservative treatment group compared to the radical treatment group, and this result is statistically significant. […] Despite the high recurrence rate, the latter was more appropriate in the case of smaller lesions and younger patients, due to better post-operative quality of life and reduced functional and esthetic impairments. […] Based on the results of this overview, conservative treatment may be recommended as the first-line approach for intraosseous ameloblastoma not involving soft tissue.

• #44

  https://link.springer.com/article/10.1007/s44178-024-00145-1

  There are numerous types of orbital tumors, among which orbital ameloblastoma is a rare metastatic benign tumor that often originates in the jaw and later metastasizes to the orbit. […] The prognosis of orbital ameloblastoma is relatively poor, but there is still hope. With aggressive treatment and close follow-up observation, patients may still have the possibility of achieving a longer survival period and a better quality of life. […] Ameloblastoma has the potential for malignant transformation in cases of frequent recurrence, similar to confirmed malignant tumors. […] Therefore, it is clinically considered as a borderline tumor that requires close monitoring and aggressive treatment. […] The metastasis of ameloblastoma is relatively rare, with only 2% of cases experiencing metastasis, usually diagnosed after retrospective analysis.

• #45

  https://link.springer.com/article/10.1007/s44178-024-00145-1

  There are numerous types of orbital tumors, among which orbital ameloblastoma is a rare metastatic benign tumor that often originates in the jaw and later metastasizes to the orbit. […] The prognosis of orbital ameloblastoma is relatively poor, but there is still hope. With aggressive treatment and close follow-up observation, patients may still have the possibility of achieving a longer survival period and a better quality of life. […] Ameloblastoma has the potential for malignant transformation in cases of frequent recurrence, similar to confirmed malignant tumors. […] Therefore, it is clinically considered as a borderline tumor that requires close monitoring and aggressive treatment. […] The metastasis of ameloblastoma is relatively rare, with only 2% of cases experiencing metastasis, usually diagnosed after retrospective analysis.

• #46

  https://link.springer.com/article/10.1007/s44178-024-00145-1

  A weakened immune system and cellular aging may increase the risk of tumor metastasis and malignant transformation, including the metastasis of ameloblastoma to the orbit. […] Although ameloblastoma is essentially a benign tumor, in some cases, tumor cells may undergo genetic mutations, leading to malignant transformation. […] Malignantly transformed tumor cells have stronger invasiveness and metastatic potential, making them more prone to orbital metastasis. […] The treatment of OAM requires close collaboration between ophthalmology, oncology, radiology, and other disciplines. In the future, interdisciplinary teams will place greater emphasis on collaboration and communication, jointly formulating comprehensive treatment plans to improve treatment outcomes and patients’ quality of life.

• #47 The Effect of Conservative vs. Radical Treatment of Ameloblastoma on Recurrence Rate and Quality of Life: An Umbrella Review

  https://www.mdpi.com/2077-0383/13/17/5339

  Conservative treatments, like enucleation, decompression, and marsupialization, were not considered as a definitive surgery, but they were useful only to lower the invasiveness of the second surgery. […] The recurrence rate after the conservative surgery is neither comparable nor lower than the radical surgery (p = 0.28). […] The primary finding of this umbrella review is that radical treatments for ameloblastoma are associated with significantly lower recurrence rates compared to conservative treatments. […] For clinicians, this review underscores the importance of weighing the benefits of lower recurrence rates against the risks of adverse outcomes, including esthetic and functional impairments. […] Further prospective studies are needed to establish the best treatment choice and follow-up period.

• #48 The Effect of Conservative vs. Radical Treatment of Ameloblastoma on Recurrence Rate and Quality of Life: An Umbrella Review

  https://www.mdpi.com/2077-0383/13/17/5339?type=check_update&version=1

  The primary finding of this umbrella review is that radical treatments for ameloblastoma are associated with significantly lower recurrence rates compared to conservative treatments. […] Therefore, researchers are encouraged to focus on high-quality, prospective studies that can provide more definitive evidence on the comparative effectiveness and safety of radical versus conservative treatments.

• #49 The Effect of Conservative vs. Radical Treatment of Ameloblastoma on Recurrence Rate and Quality of Life: An Umbrella Review

  https://www.mdpi.com/2077-0383/13/17/5339

  Conservative treatments, like enucleation, decompression, and marsupialization, were not considered as a definitive surgery, but they were useful only to lower the invasiveness of the second surgery. […] The recurrence rate after the conservative surgery is neither comparable nor lower than the radical surgery (p = 0.28). […] The primary finding of this umbrella review is that radical treatments for ameloblastoma are associated with significantly lower recurrence rates compared to conservative treatments. […] For clinicians, this review underscores the importance of weighing the benefits of lower recurrence rates against the risks of adverse outcomes, including esthetic and functional impairments. […] Further prospective studies are needed to establish the best treatment choice and follow-up period.

• #50 The Effect of Conservative vs. Radical Treatment of Ameloblastoma on Recurrence Rate and Quality of Life: An Umbrella Review

  https://www.mdpi.com/2077-0383/13/17/5339

  Conservative treatments, like enucleation, decompression, and marsupialization, were not considered as a definitive surgery, but they were useful only to lower the invasiveness of the second surgery. […] The recurrence rate after the conservative surgery is neither comparable nor lower than the radical surgery (p = 0.28). […] The primary finding of this umbrella review is that radical treatments for ameloblastoma are associated with significantly lower recurrence rates compared to conservative treatments. […] For clinicians, this review underscores the importance of weighing the benefits of lower recurrence rates against the risks of adverse outcomes, including esthetic and functional impairments. […] Further prospective studies are needed to establish the best treatment choice and follow-up period.

• #51 The Effect of Conservative vs. Radical Treatment of Ameloblastoma on Recurrence Rate and Quality of Life: An Umbrella Review

  https://www.mdpi.com/2077-0383/13/17/5339?type=check_update&version=1

  The primary finding of this umbrella review is that radical treatments for ameloblastoma are associated with significantly lower recurrence rates compared to conservative treatments. […] Therefore, researchers are encouraged to focus on high-quality, prospective studies that can provide more definitive evidence on the comparative effectiveness and safety of radical versus conservative treatments.

• #52

  https://link.springer.com/article/10.1007/s40615-024-01993-3

  While we did not find significance for size of ameloblastomas, the mean tumor size trended larger in the Black patients compared to the White patients. […] With respect to recurrence rate of 9 of the 129 total cases (7.0%), our rate is in agreement with the rate of 6.8% found in Nigeria where surgical resection was utilized as the primary treatment method. […] More data is needed to clearly elucidate any relationship between the tumor size and race, as factors such as time of discovery may impact the ultimate patient outcomes. […] In conclusion, we have shown the higher prevalence of ameloblastomas in Black patients within the southern United States over a ten-year period. Critically, we found significance between the age of Black and White patients, with Black patients presenting with ameloblastomas around 7 years earlier on average.

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