Materiały źródłowe

• #1 Ehlers-Danlos syndrome – Symptoms and causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/ehlers-danlos-syndrome/symptoms-causes/syc-20362125

  People who have Ehlers-Danlos syndrome usually have overly flexible joints and stretchy, fragile skin. This can become a problem if you have a wound that requires stitches, because the skin often isn’t strong enough to hold them. […] There are many different types of Ehlers-Danlos syndrome, but the most common signs and symptoms include: […] Overly flexible joints. Because the connective tissue that holds joints together is looser, your joints can move far past the normal range of motion. Joint pain and dislocations are common. […] Stretchy skin. Weakened connective tissue allows your skin to stretch much more than usual. You may be able to pull a pinch of skin up away from your flesh, but it will snap right back into place when you let go. Your skin might also feel exceptionally soft and velvety.

• #2 Ehlers-Danlos Syndrome | Cedars-Sinai

  https://www.cedars-sinai.org/health-library/diseases-and-conditions/e/ehlers-danlos-syndrome.html

  Ehlers-Danlos syndrome (EDS) is a group of rare genetic disorders. These disorders affect the way collagen is made or used in the body. Collagen is a type of protein. It adds strength and structure to organs and connective tissues. Problems with collagen can affect many parts of the body, including the skin, joints, blood vessels, bones, cartilage, and tendons. […] The symptoms of EDS vary from person to person. They also depend on the type of EDS a person has. Some types can cause mild symptoms, while others can be life-threatening. […] EDS mainly affects the skin and joints. Symptoms of the most common types of EDS include: Soft, thin, stretchy skin, Abnormal scarring of the skin, Joints that move too much and that can easily dislocate, Joint and muscle pain, Fatigue, Muscle weakness, Skin growths on the knees or elbows, Hard bumps under the skin, Easy bruising, Wounds that take a long time to heal.

• #3 What is EDS? – The Ehlers Danlos Society

  https://www.ehlers-danlos.com/what-is-eds/

  Each type of EDS is associated with different symptoms and characteristics. Some symptoms are common across all types of EDS, such as joint hypermobility, pain, and fatigue. Other symptoms are only observed in specific types of EDS. Even within the same type of EDS, people can experience very different symptoms from each other. […] Tissue fragility can present as easy bruising and poor wound healing in many types of EDS. Some types of EDS can also cause severe fragility of the skin, blood vessels, abdominal organs, eyes, gums, and bones. […] Joint instability can cause both acute and chronic pain and interfere with daily life.

• #4 Hypermobile Ehlers-Danlos Syndrome: Clinical Description and Natural History (for Non-experts) – The Ehlers Danlos Society

  https://www.ehlers-danlos.com/2017-eds-classification-non-experts/hypermobile-ehlers-danlos-syndrome-clinical-description-natural-history/

  Hypermobile type Ehlers-Danlos syndrome (hEDS) is the most common subtype of the Ehlers-Danlos syndromes (EDS) and possibly the most common of all hereditary disorders of connective tissue (HDCT). […] hEDS is mainly identified by generalized joint hypermobility (GJH), additional joint issues, and obvious skin signs, which are less severe than those seen in Classic EDS (cEDS) or Vascular EDS (vEDS). […] If a person has hEDS, it will likely affect them in different ways throughout their lifetime, and the person may be diagnosed with many other conditions known to occur in those with hEDS. […] Existing studies show that children with hEDS who experience pain will be more likely to have pain limited to lower limbs (e.g., growing pains) and pain caused by repetitive tasks such as handwriting in the school setting.

• #5

• #6 Ehlers Danlos Syndromes | Arthritis Foundation

  https://www.arthritis.org/diseases/ehlers-danlos-syndromes

  Hypermobile EDS is the most common type, making up around 80% to 90% of cases. Its hallmark is loose, stretchy ligaments and tendons, which make for unstable, painful joints that may be prone to osteoarthritis. People with hypermobile EDS can have lots of other complications, including chronic fatigue, chronic pain, heart-related (cardiovascular) dysautonomia, gastrointestinal problems, urinary problems, and anxiety, depression and other mental health issues. […] Diagnosis usually starts with a medical history and a physical exam to check for obvious signs like hyperflexible joints and stretchy skin. […] Theres no cure for EDS yet, so treatment focuses on relieving symptoms and preventing complications.

• #7 Ehlers-Danlos Syndrome: Symptoms, Causes & Treatment

  https://my.clevelandclinic.org/health/diseases/17813-ehlers-danlos-syndrome

  Ehlers-Danlos syndrome can affect tissue throughout your body and cause many different symptoms. […] Each type of Ehlers-Danlos syndrome has its own symptoms, but the most common EDS symptoms include: overly flexible (hypermobile) joints it might feel like your joints are loose or unstable, soft skin that’s thinner and stretches more than it should, bruising easily or more often than usual, unusual scarring or taking unusually long to heal after a cut or small wound, joint and muscle pain, fatigue (feeling tired all the time), difficulty concentrating. […] The most common types cause symptoms like loose or unstable joints and fragile skin that tears easily. […] Some types of Ehlers-Danlos syndrome can cause life-threatening complications. Vascular Ehlers-Danlos syndrome can cause blood vessels to rupture (tear). This can lead to dangerous internal bleeding and stroke.

• #8 Ehlers-Danlos syndromes

  https://www.nhs.uk/conditions/ehlers-danlos-syndromes/

  Ehlers-Danlos syndromes (EDS) are a group of rare inherited conditions that affect connective tissue. […] There are several types of EDS that may share some symptoms. These include: an increased range of joint movement (joint hypermobility), stretchy skin, fragile skin that breaks or bruises easily. […] EDS can affect people in different ways. For some, the condition is relatively mild, while for others their symptoms can be disabling. […] Some of the rare, severe types can be life threatening. […] People with hEDS may have: joint hypermobility, loose, unstable joints that dislocate easily, joint pain and clicking joints, extreme tiredness (fatigue), skin that bruises easily, digestive problems, such as heartburn and constipation, dizziness and an increased heart rate after standing up, problems with internal organs, such as mitral valve problems or organ prolapse, problems with bladder control (urinary incontinence).

• #9 Ehlers-Danlos Syndrome in Orthopaedics

  https://pmc.ncbi.nlm.nih.gov/articles/PMC3435946/

  Ehlers-Danlos syndrome is a heterogeneous connective tissue condition characterized by varying degrees of skin hyperextensibility, joint hypermobility, and vascular fragility. Joint dislocations, musculoskeletal pain, atrophic scars, easy bleeding, vessel/viscera rupture, severe scoliosis, and obstetric complications may occur. […] Ehlers-Danlos syndrome (EDS) is a connective tissue disorder characterized by varying degrees of skin hyperextensibility, joint hypermobility, and vascular fragility. […] The hypermobility type is associated with the most debilitating musculoskeletal manifestations, and joint pain is reported by 100% of patients. […] The stiffness phase with progressive limitation of joint motion develops later. […] The vascular type is characterized by fragile viscera and therefore has the most serious consequences, such as arterial, intestinal, or uterine rupture.

• #10 Systemic manifestations of Ehlers-Danlos syndrome

  https://pmc.ncbi.nlm.nih.gov/articles/PMC7785142/

  Ehlers-Danlos syndrome (EDS) is a multifaceted debilitating disease. Affected patients are at risk for complications such as joint hypermobility and cardiac disease, but the prevalence, course, and management of these conditions are not well understood. […] On average, each patient reported involvement of 5.4 joints, with the shoulder, knee, and lumbar spine as the most common. The average number of comorbid systemic conditions was 2.8, of which autonomic dysfunction was the most common. […] All patients reported musculoskeletal pain with more than one joint affected, consistent with a study by Rombaut et al that found joint pain in 100% of patients. […] Autonomic dysfunction, or dysautonomia, often presents with palpitations, dizziness, and syncope. […] About 50% of patients in this study had been evaluated for at least one gastrointestinal-related symptom: 69% of patients had unspecified chronic abdominal pain, 54% had frequent nausea and vomiting, 40% had gastroesophageal reflux disorder, 29% had chronic constipation or diarrhea, and 7% had hernias.

• #11 The Natural Approach to Treat Ehlers-Danlos Syndrome –

  https://caringmedical.com/home/conditions/natural-approach-treat-ehlers-danlos-syndrome/

  Since 1993, Caring Medical has successfully treated the symptomology of Ehlers-Danlos syndrome, hypermobility type (hEDS) using natural holistic interventions including Prolotherapy, diet modification, herbal remedies and others. […] Chronic pain is the most prevalent symptom in EDS patients. […] The authors concluded, „Therefore, the treatment of pain should be a prominent aspect of symptomatic management of EDS.” […] In another comprehensive study on EDS, researchers found that over 90% of EDS patients suffered from chronic pain; eight was the mean number of pain locations; 70% reported continuous pain in the lower extremities, ankles, feet, toes, and hips; 89% of their pain began in childhood or adolescence; 88% were taking or had taken pain medications; and 51% needed narcotics for pain control.

• #12

  https://www.chronicpainpartners.com/diagnosing-eds/

  The Hypermobility Type is the most common form of Ehlers-Danlos Syndrome. It is characterized by loose, hypermobile joints and chronic joint pain. […] The Classical Type of EDS is characterized by highly elastic, soft, and doughy skin, as well as unusual scarring and loose joints. […] The Vascular Type of EDS is characterized by possible arterial or organ rupture as a result of spontaneous rupture of vessels or organs due to the result of even minor trauma. The Vascular Type of EDS is the most serious form of Ehlers-Danlos Syndrome.

• #13 Ehlers-Danlos syndrome – Symptoms and causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/ehlers-danlos-syndrome/symptoms-causes/syc-20362125

  Fragile skin. Damaged skin often doesn’t heal well. For example, the stitches used to close a wound often will tear out and leave a gaping scar. These scars may look thin and crinkly. […] Symptom severity can vary from person to person and depends on the specific type of Ehlers-Danlos syndrome that you have. The most common type is called hypermobile Ehlers-Danlos syndrome. […] Complications depend on the types of signs and symptoms you have. For example, overly flexible joints can result in joint dislocations and early-onset arthritis. Fragile skin may develop prominent scarring. […] People who have vascular Ehlers-Danlos syndrome are at risk of often fatal ruptures of major blood vessels. Some organs, such as the uterus and intestines, also may rupture. Pregnancy can increase the risk of a rupture in the uterus.

• #14 Ehlers-Danlos Syndrome 101 – Hypermobility and Ehlers-Danlos Clinic @ The Fascia Institute

  https://hypermobilityclinic.org/ehlers-danlos-syndrome-101/

  Ehlers-Danlos Syndrome (EDS) is an umbrella term for a heterogeneous group of inherited connective tissue disorders characterized by symptoms including, but not limited to, skin hyperextensibility, joint hypermobility, and vascular fragility. […] In addition to skin hyperextensibility and joint hypermobility, patients with EDS can present with easy bleeding/bruising, atrophic scarring, aortic root dilation, mitral valve prolapse, gastrointestinal complications, scoliosis, and chronic joint pain, among other concerns. […] Chronic, life-long joint hypermobility likely with compounded subluxations and dislocations will almost assuredly lead to issues like arthritis, cartilage tears, tendinopathies, etc., and studies have shown that up to 100% of EDS patients eventually report some form of chronic joint or back pain. […] EDS is a chronic, inherited connective tissue disorder that can present with a wide variety of clinical features, the most common of which revolve around joint pain and hypermobility.

• #15 What Is Ehlers-Danlos Syndrome (EDS)? Symptoms, and Causes

  https://www.healthline.com/health/ehlers-danlos-syndrome

  People with EDS may experience increased joint mobility and have stretchy, fragile skin thats prone to breaking. […] Your EDS symptoms will vary depending on what type of EDS you have. The severity of symptoms will also be different between people experiencing the same type of EDS. […] One common symptom of EDS is joint hypermobility, which is when theres a greater range of movement in a joint than usual. EDS can affect collagen function in the tendons and cartilage in your joints, which can lead to hypermobility. EDS can affect all of the joints in the body. […] In mild cases, a person will be able to move joints in a greater range of movement than normal and may experience light pain during activities. In more severe cases, a person may be at a greater risk of joint dislocations and joint instability.

• #16 Ehlers-Danlos syndromes

  https://www.nhs.uk/conditions/ehlers-danlos-syndromes/

  Classical EDS (cEDS) is less common than hypermobile EDS and tends to affect the skin more. People with cEDS may have: joint hypermobility, loose, unstable joints that dislocate easily, stretchy skin, fragile skin that can split easily, especially over the forehead, knees, shins and elbows, smooth, velvety skin that bruises easily, wounds that are slow to heal and leave wide scars, hernias and organ prolapse. […] Vascular EDS (vEDS) is a rare type of EDS and is often considered to be the most serious. It affects the blood vessels and internal organs, which can cause them to split open and lead to life-threatening bleeding. People with vEDS may have: skin that bruises very easily, thin skin with visible small blood vessels, particularly on the upper chest and legs, fragile blood vessels that can bulge or tear, resulting in serious internal bleeding, a risk of organ problems, such as the bowel tearing, the womb tearing (in late pregnancy) and partial collapse of the lung, hypermobile fingers and toes, unusual facial features (such as a thin nose and lips, large eyes and small earlobes), varicose veins and delayed wound healing.

• #17 Genetics of Ehlers-Danlos Syndrome: Practice Essentials, Pathophysiology, Epidemiology

  https://emedicine.medscape.com/article/943567-overview

  All EDS types share the following cutaneous features: Loose, hyperextensible, fragile skin. Poor wound healing. Tendency to bruise easily. Atrophic scars that are wide and thin, known as „cigarette paper scars.” […] The following extracutaneous features are also shared: Fragility of blood vessels. Hyperextensible, hypermobile joints. Propensity for spontaneous joint dislocations/subluxations. […] Reduced life expectancy is not generally a feature of Ehlers-Danlos syndrome (EDS), with the exception of vascular-type EDS (type IV). Median life expectancy for patients with vascular-type EDS is 50 years because medium-sized arteries, and the gastrointestinal tract, can spontaneously rupture. Uterine rupture during pregnancy has also been reported. […] Morbidity in EDS is related to the primary pathophysiology and includes dislocations, pain, or both from chronic joint laxity and instability. Aberrant wound healing and scarring due to abnormal tensile strength of the skin also happens. […] Ehlers-Danlos syndrome is a genetic disorder. As such, this syndrome and its various types are present at birth; however, symptoms may not become apparent until later in life.

• #18 Ehlers-Danlos Syndrome: Symptoms, Diagnosis, Treatment

  https://www.webmd.com/a-to-z-guides/ehlers-danlos-syndrome-facts

  Ehlers-Danlos syndrome (EDS) is an inherited condition that weakens your connective tissues, which hold parts of your body together. These include your bones and cartilage, as well as your blood and fatty tissue. As a result, EDS can make your joints loose and your skin thin and easily bruised. It can also weaken your blood vessels and organs. […] There’s no cure yet for EDS, but your symptoms can be treated and managed. […] Symptoms vary based on which type of EDS you have. Some of the most common signs are: Overly flexible joints. For example, you may be able to push your thumbs all the way to your forearm or bend your knees backward. Stretchy skin. You can pull your skin away from your body, and it snaps back. It might also be very soft and velvety. Bruising easily. Your skin may be very fragile. It may bruise and scar easily, and your wounds could take a long time to heal.

• #19 Classic Ehlers-Danlos Syndrome (cEDS) – Ehlers-Danlos Syndromes New Zealand

  https://ehlers-danlos.org.nz/ceds/?srsltid=AfmBOor6HrFmT4cwObv39vHNdIDBFtYWocLZTduzMT7bQ11EJsbUprnJ

  Common symptoms include joint hypermobility, skin hyperextensibility, and skin fragility leading to atrophic scarring and significant bruising. […] The signs and symptoms of classical EDS vary but may include: Smooth, velvety skin that is highly elastic (stretchy) and bruises easily. Abnormal wound healing that may result in wide, atrophic scars (flat and/or depressed scars). Joint hypermobility that leads to frequent dislocations and subluxations (partial dislocations). Molluscoid pseudotumors (calcified hematomas over pressure points such as the elbow). Subcutaneous spheroids (fat-containing cysts that are often found on the forearms and/or shins). Hypotonia. Delayed motor development. Tissue fragility that may lead to hernias, rectal prolapse, and other complications. Cardiovascular abnormalities such as mitral valve prolapse or aortic root dilatation (enlargement of the blood vessel that distributes blood from the heart to the rest of the body). Pregnancy may be complicated by premature rupture of membranes.

• #20 Ehlers-Danlos syndrome: MedlinePlus GeneticsLock

  https://medlineplus.gov/genetics/condition/ehlers-danlos-syndrome/

  Many people with the Ehlers-Danlos syndromes have soft, velvety skin that is highly stretchy (elastic) and fragile. Affected individuals tend to bruise easily, and some types of the condition also cause abnormal scarring. People with the classical form of Ehlers-Danlos syndrome experience wounds that split open with little bleeding and leave scars that widen over time to create characteristic „cigarette paper” scars. The dermatosparaxis type of the disorder is characterized by loose skin that sags and wrinkles, and extra (redundant) folds of skin may be present. […] Bleeding problems are common in the vascular type of Ehlers-Danlos syndrome and are caused by unpredictable tearing (rupture) of blood vessels and organs. These complications can lead to easy bruising, internal bleeding, a hole in the wall of the intestine (intestinal perforation), or stroke. During pregnancy, women with vascular Ehlers-Danlos syndrome may experience rupture of the uterus. Additional forms of Ehlers-Danlos syndrome that involve rupture of the blood vessels include the kyphoscoliotic, classical, and classical-like types.

• #21 Ehlers-Danlos Syndrome in Orthopaedics

  https://pmc.ncbi.nlm.nih.gov/articles/PMC3435946/

  Arterial rupture is the most common cause of death. […] Scoliosis is another manifestation of EDS and may be present in patients with any type of EDS. However, deformity in patients with the kyphoscoliosis type may be particularly severe and develop after rapid progression. […] EDS may be associated with an increased risk of complications during pregnancy and delivery. […] Pain is common, particularly in classical- and hypermobile-type EDS. […] The diagnosis of EDS allows clinicians to take into consideration the underlying tissue abnormalities and modify the treatment regimens of the individual manifestations accordingly.

• #22 Symptoms of Vascular Ehlers-Danlos syndrome – The VEDS Movement

  https://thevedsmovement.org/veds/how-is-the-body-affected/

  The following are symptoms found in people with Vascular Ehlers-Danlos Syndrome (VEDS): […] There is an increased risk of coronary artery dissection, and as a result, myocardial infarction (heart attack). In the event of myocardial infarct, there is an increased risk of ventricular rupture and pericardial tamponade (compression of the heart caused by fluid collecting in the sac surrounding the heart), resulting in sudden death. […] Early onset of varicose veins […] Arterial rupture may be preceded by aneurysm, arteriovenous fistulae (abnormal communication between an artery and a vein) or dissection, or may occur spontaneously. […] The aorta, the main blood vessel that carries blood from the heart to the rest of the body, may enlarge or bulge (aortic dilation or aneurysm) […] Some joints may be very flexible (double-jointed), typically the smaller joints.

• #23 Ehlers-Danlos syndrome | healthdirect

  https://www.healthdirect.gov.au/ehlers-danlos-syndrome

  Ehlers Danlos syndrome (EDS) are a group of 13 genetic conditions that affect the joints, skin and blood vessels. […] Each type of EDS has unique symptoms, but symptoms common to all EDS subtypes include flexible joints, being double-jointed and having stretchy or fragile skin. […] While each type of EDS has its own unique symptoms, symptoms common among the different types of EDS include: flexible and loose joints being double-jointed (hypermobility), stretchy skin (skin hyperextensibility), fragile skin, that bruises easily or heals poorly. […] Other symptoms can include: chronic musculoskeletal pain (pain that affects bones, joints or muscles), fatigue, cognitive impairment, clumsiness or poor coordination, muscle weakness, headaches, anxiety, gastrointestinal problems. […] Some of the problems associated with EDS, such as joint dislocations and other symptoms, tend to get worse over time. Maintaining your health and wellbeing, in partnership with your medical team, may reduce or slow the rate of any complications.

• #24 What Is the Life Expectancy for Someone With Ehlers-Danlos Syndrome?

  https://www.emedicinehealth.com/ehlers-danlos_syndrome_life_expectancy/article_em.htm

  Hypermobility is a sign of Ehlers-Danlos syndrome. […] Symptoms and signs of Ehlers-Danlos syndrome include the following: Loose and overly flexible joints (hypermobility) […] Shoulder dislocation is often an early sign. […] Stretchy skin (hyperextensibility). […] Easy bruising. […] Thin, fragile skin […] Cuts occur easily. […] Cuts take longer to heal. […] Healed cuts can leave abnormal-looking scars. […] Dizziness on standing. […] Urinary incontinence. […] Diarrhea. […] Poor postural control. […] Generalized pain. […] Fatigue. […] Muscle weakness. […] Tendency to fall easily. […] Difficulty walking (sometimes). […] Some types of Ehlers-Danlos syndrome can cause serious problems such as heart problems (uncommon, occurs with the vascular type of the disease) and a rupture or tear inside the body (only a risk with certain types of EDS).

• #25 Ehlers-Danlos Syndrome: Symptoms, Causes & Treatment

  https://my.clevelandclinic.org/health/diseases/17813-ehlers-danlos-syndrome

  Your risk of complications depends on which type of EDS you have. Complications can include: problems with the valves that push blood through your heart, severe spine curvature (scoliosis), thin corneas in your eyes, bowed (curved) limbs, teeth and gum problems. […] You should expect to manage Ehlers-Danlos syndrome symptoms for the rest of your life. There’s no cure for EDS. But you should be able to participate in all your normal activities once you learn how to manage your symptoms. […] Most types of Ehlers-Danlos syndrome don’t affect or lower your life expectancy. If you have EDS that affects your blood vessels (vascular Ehlers-Danlos syndrome), you might have an increased risk of experiencing a stroke or other fatal vascular issues.

• #26 hEDS – The Ehlers Danlos Society

  https://www.ehlers-danlos.com/heds/

  hEDS may be suspected if a person has: Joint hypermobility, Joint instability, Chronic pain, Mild skin hyperextensibility, Abnormal scarring. […] People with hEDS may also have: Chronic fatigue, Gastrointestinal issues, Dysautonomia, Headaches, Mast cell activation diseases. […] hEDS can cause a variety of symptoms in many areas of the body, so people with hEDS may require multiple providers in different specialties to manage their care. Key aspects of care include physical therapy and pain management. […] Most people with hEDS have chronic pain that persists over a long period of time. hEDS can also cause acute pain that lasts for a shorter period due to something specific, like an injury. […] Many people with hEDS have chronic fatigue, which is constant or recurring fatigue that lasts for more than six months.

• #27 Growing Up with Ehlers-Danlos Syndrome: 27 Telltale Signs | The EDS Clinic

  https://www.eds.clinic/articles/growing-up-with-ehlers-danlos-syndrome-27-telltale-signs

  Ehlers-Danlos Syndrome (EDS) is a rare genetic disorder that affects the body’s connective tissues, causing joint hypermobility, skin fragility, and other symptoms. […] Many people with EDS experience symptoms from a young age, making it a part of their childhood and adolescence. […] The most common type is hypermobile EDS, which is characterized by joint hypermobility, skin fragility, and chronic pain. […] People with EDS often experience frequent subluxations, especially in the shoulders, hips, and knees. […] Along with subluxations, joint instability is a common symptom of EDS. This can make it difficult to participate in physical activities and can lead to chronic pain. […] One of the most well-known symptoms of EDS is stretchy skin, but not everybody has this telltale symptom.

• #28 Hypermobile Ehlers-Danlos Syndrome: Clinical Description and Natural History (for Non-experts) – The Ehlers Danlos Society

  https://www.ehlers-danlos.com/2017-eds-classification-non-experts/hypermobile-ehlers-danlos-syndrome-clinical-description-natural-history/

  The pain phase is often accompanied by diagnosis with fibromyalgia or other long-term (chronic) pain conditions and perhaps chronic fatigue, typically starting in the second to fourth decade and accompanied by chronic pain, headaches, digestive system disorders, among others. […] Chronic, debilitating fatigue is common in hEDS, and such fatigue has significant impact on mental and physical function and ultimately on quality of life. […] Heart and blood vessel conditions occurring in hEDS include heart valve and vessel dysfunction including mitral valve prolapse (MVP) and aortic root dilation. […] As many as 75% of people with hEDS are likely to encounter problems with the function of their digestive system in their lifetime. […] An extensive body of literature clearly indicates frequent problems with involuntary bodily functions (dysautonomia) in hEDS.

• #29 Autonomic dysfunction

  https://www.ehlers-danlos.org/information/autonomic-dysfunction/

  Many of the common symptoms reported relate to changes in posture. They occur when changing from a lying or sitting to a standing position, and are relieved by sitting or lying down. These include: Fast heart rate (palpitations), Dizziness, Light-headedness, Blurring of vision, Loss of concentration, Fear of or actual blacking out, Swelling in the legs after standing for only relatively short periods of time (e.g. 30 mins). […] Individuals often also notice associated tiredness, tremor, sweating, anxiety and clumsiness at the same time. The symptoms are often more sudden or more severe if: Dehydrated, Anaemic (low red cell blood count), In a hot environment, After exercise, After alcohol or caffeine, During other illness, After long periods of rest. […] Other symptoms may NOT be related to sudden changes in posture. These include: Tiring easily, Reduced concentration, Inability to exercise, Intolerance of hot or cold environments, Anxiety, Excessive sweating, Muscle and joint pain, Bowel dysfunction akin to irritable bowel syndrome.

• #30 Growing Up with Ehlers-Danlos Syndrome: 27 Telltale Signs | The EDS Clinic

  https://www.eds.clinic/articles/growing-up-with-ehlers-danlos-syndrome-27-telltale-signs

  Joint pain is a common symptom of EDS, often caused by the constant strain on the joints due to hypermobility and instability. […] Due to the fragility of their skin, people with EDS may experience poor wound healing, making it difficult for cuts and bruises to heal properly. […] Some types of EDS can affect the heart, leading to issues such as heart valve problems and aortic aneurysms. […] Muscle weakness is a common symptom of EDS, which can affect daily activities and lead to chronic pain. […] Chronic headaches are a common symptom of EDS, often caused by muscle tension and joint pain. […] Living with a chronic condition like EDS can take a toll on mental health, leading to anxiety and depression. […] Chronic pain and discomfort can make it difficult for people with EDS to get a good night’s sleep, leading to fatigue and other issues.

• #31 Hypermobile Ehlers-Danlos Syndrome: Clinical Description and Natural History (for Non-experts) – The Ehlers Danlos Society

  https://www.ehlers-danlos.com/2017-eds-classification-non-experts/hypermobile-ehlers-danlos-syndrome-clinical-description-natural-history/

  Osteoarthritis (a breakdown of joints) has been described in the literature as a possible long-term consequence of JH for decades. […] Headaches in general, as well as migraines in particular, are known to occur more frequently in persons with EDS than in the general population. […] People with hEDS may have neck pain, difficulty walking, numbness and tingling of the hands and feet, dizziness, swallowing difficulties, and changes in speech. […] While the existing literature suggests that pelvic floor problems including urinary incontinence or uterine, rectal, or bladder prolapse are common to hEDS, many studies did not control for childbirth history, and included various EDS types. […] People with hEDS often experience significant sleep deprivation. […] Many with hEDS are assigned psychiatric diagnoses or frankly ignored when clinicians fail to recognize that they meet diagnostic criteria for hEDS. […] Carefully designed studies have clearly demonstrated that quality of life is often measured or reported as lower in people with EDS than in the general population in particular, people with EDS and associated secondary issues such as digestive system disorders, anxiety, depression, physical pain.

• #32 hEDS – The Ehlers Danlos Society

  https://www.ehlers-danlos.com/heds/

  People with hEDS may get headaches for several different reasons, including: Migraines, Muscle tension, Idiopathic intracranial hypertension, Dysautonomia, Craniocervical instability, Temporomandibular joint dysfunction, Cerebrospinal fluid leaks, Cervical spine disorders. […] People with hEDS may feel uneasy and feel the need to vomit. […] Some people with hEDS experience pain in the abdomen, the midsection of the body that contains the gastrointestinal system and other organs. […] People with hEDS may have infrequent or difficult bowel movements. […] People with hEDS who menstruate are more likely to have painful periods (dysmenorrhea) and heavy periods or periods that last longer than usual (menorrhagia). […] People with hEDS may experience changes in their symptoms during pregnancy. This may include the worsening of the following: Pain, Joint instability, Gastrointestinal issues, Dysautonomia, Mast cell activation syndrome.

• #33 Cognitive and Psychopathological Aspects of Ehlers-Danlos Syndrome – Experience in a Specialized Medical Consultation

  https://www.gavinpublishers.com/article/view/cognitive-and-psychopathological-aspects-of-ehlersdanlos-syndrome-experience-in-a-specialized-medical-consultation

  This includes working memory (73%), attention (77%). The latter is responsible for the sign of jumping from one subject to the other with many side comments and difficulty to channel the patient’s speech, which further complicate exchanges. Concentration is concerned, with difficulties in maintaining the same activity for a long time, or in poor temporal or spatial orientation with a very bad sense of orientation.

• #34 Weird symptoms of Ehlers Danlos Syndrome that people may not recognize | The EDS Clinic

  https://www.eds.clinic/articles/weird-symptoms-of-ehlers-danlos-syndrome-that-most-doctors-dont-recognize

  Ehlers-Danlos Syndromes (EDS) are a group of heritable connective tissue disorders, characterized by a variety of symptoms due to the widespread nature of connective tissue in the body. While certain symptoms of EDS are well-documented and can be found through sources like Google, there are less commonly discussed symptoms that might not be as widely known. These include: […] Neurological Symptoms: Including headaches, migraines, neuropathic pain, and cognitive difficulties such as „brain fog.” […] Fatigue: Persistent and debilitating tiredness not related to physical activity levels. […] Temperature Dysregulation: Difficulty regulating body temperature, leading to excessive sweating or intolerance to heat or cold. […] Clumsiness: Frequent injuries and clumsiness due to problems with body awareness and spatial orientation.

• #35 What Are the 3 Phases of Hypermobile Ehlers-Danos Syndrome and Hypermobility Spectrum Disorder?

  https://experiencelife.lifetime.life/article/what-are-the-three-phases-of-hypermobile-ehlers-danos-syndrome-and-hypermobility-spectrum-disorder/

  The pain phase is the second stage for those with hEDS or HSD. Between these first two phases, theres often a period of mystery ailments and injuries, Bluestein notes. This might include joint instability, musculoskeletal pain, gut symptoms, migraines, or mast-cell activation such as eczema, asthma, and allergies. […] The pain phase is when the nervous system has had enough painful input that someone starts to develop nociplastic pain, Bluestein explains. Nociplastic pain (sometimes called central sensitization) arises from pain signals that have become distorted or overly sensitized in the central nervous system. […] It comes when people have been in pain for a while, so their nervous system is just not able to filter things out, she says. This phase usually arises in someones second, third, or fourth decade of life.

• #36 Aging with Hypermobility and EDS | Jeannie Di Bon

  https://jeanniedibon.com/aging-with-eds/

  It always surprises me that patients are often told by their doctors that EDS gets better with age so no need to worry about it. […] However, the symptoms and complications of EDS could become more pronounced as a person ages, leading to the perception it is progressive. […] In a series of studies by an Italian research group, a three-step model was developed to describe how they often observe hEDS progression. […] The 3 Phases include: Hypermobility phase: Childhood the first decade of life, Pain Phase: The Second to 4th Decade of life, Stiffening phase. […] Please note that a group of experts cited these stages but made it clear that it may be a prototype of how it progresses and stated not every patient experiences all three phases and the rate of transition between these phases can be highly variable. […] Symptoms may get worse over time due to a variety of reasons, but this does not occur in a linear pattern and is different for everyone with EDS. In that sense, it is not progressive.

• #37 What Are the 3 Phases of Hypermobile Ehlers-Danos Syndrome and Hypermobility Spectrum Disorder?

  https://experiencelife.lifetime.life/article/what-are-the-three-phases-of-hypermobile-ehlers-danos-syndrome-and-hypermobility-spectrum-disorder/

  This is when we see most of our patients presenting. They might have had injuries from hypermobility ongoing for years, and [the underlying cause] has been undiagnosed, says Dacre Knight, MD, medical director of the Ehlers-Danlos Syndrome Clinic at Mayo Clinic in Jacksonville, Fla. He notes that the average timespan from symptom onset to diagnosis is more than 10 years. […] A trigger such as an injury or infection can also launch someone into the second phase. If the immune system gets activated, we get more inflammation, which can increase pain and other symptoms, Bluestein says. Its not uncommon for children with hEDS or HSD to be functioning at a high level until they hit a certain trigger. […] Puberty itself may serve as a trigger thanks to changing hormones. This may include issues with mast cells, which are white blood cells that play an important role in the immune system and are found throughout the connective tissue.

• #38 What Are the 3 Phases of Hypermobile Ehlers-Danos Syndrome and Hypermobility Spectrum Disorder?

  https://experiencelife.lifetime.life/article/what-are-the-three-phases-of-hypermobile-ehlers-danos-syndrome-and-hypermobility-spectrum-disorder/

  We dont know how much of the increase in symptoms around the time of puberty, especially in females, is due to cycling hormones or mast cells, Bluestein says. But theres data on other painful conditions that puberty is a critical time of increased pain and a real change in trajectory. […] The joint-stiffening phase is the third stage, and typically comes in the fifth, sixth, or seventh decade of life. While this phase can bring the downsides of joint degeneration and osteoarthritic pain that are common across the general population, stiffer joints may also reduce dislocations and injuries in hypermobile people, Knight says. […] People with hEDS or HSD do not have decreased life expectancy. So, all of our focus is on improving quality of life, Knight says. Ideally, this means recognizing and diagnosing hypermobility and its related conditions early, to avoid greater complications down the road.

• #39 Does EDS get worse as you age? – The Fibro Guy

  https://www.thefibroguy.com/blog/does-eds-get-worse-as-you-age/

  Some research suggests that joint laxity in hypermobile Ehlers-Danlos syndrome (hEDS) tends to decline after the third decade of life, but that doesn’t mean symptoms improve. Instead, as connective tissue changes, the body shifts toward a different kind of instability: one marked by chronic stiffness, compensatory muscle tension, and increased joint degeneration. […] In fact, many find that as hypermobility decreases, pain actually increases, often due to years of microtrauma, proprioceptive deficits, and the body’s attempt to compensate for weakened connective tissue. […] What starts as excessive movement in youth often transitions into a cycle of stiffness, fatigue, and joint deterioration in midlife, showing that aging with hEDS isn’t as simple as hypermobility fading away, it just changes form, and this can be true for many hypermobility symptoms.

• #40 Classic Ehlers-Danlos Syndrome (cEDS) – Ehlers-Danlos Syndromes New Zealand

  https://ehlers-danlos.org.nz/ceds/?srsltid=AfmBOor6HrFmT4cwObv39vHNdIDBFtYWocLZTduzMT7bQ11EJsbUprnJ

  Skin is hyperextensible and soft, often described as velvety, with severe atrophic scarring and haemosiderin deposition over the shins and extensor surfaces. The skin is fragile and tears or bruises very easily. […] Joint hypermobility is present. This will be evidenced by the presence of a Beighton score of 5 or greater, either on examination or historically. Joint instability complications may comprise sprains, dislocation/subluxation, temporomandibular joint dysfunction, pain and pes planus, dyspraxia, and early osteoarthritis. Mild muscle hypotonia, and some skeletal morphological alterations (scoliosis, pectus deformities, elbow/genus/hallux valgus) are regularly observed. Pre-menopausal osteopenia or an increased bone fragility in the presence of a bone mineral density within the range may occur.

• #41 Ehlers-Danlos Syndrome is an invisible condition

  https://hdsunflower.com/uk/insights/post/ehlers-danlos-syndrome-eds

  Hypermobile EDS is the most common type and symptoms include: Fatigue, Hypermobility of joints, Unstable and loose joints that dislocate easily, Joint pain and clicking joints, Easily bruised skins, Heartburn, constipation, and similar digestive problems, Urinary incontinence, Increased heart rate and dizziness after standing up. […] Classical EDS is less common than hypermobile EDS and often affects the skin more. Symptoms include: Stretchy skin, Hernias and organ prolapse, Fragile skin that tends to split easily, especially over the knees, forehead, elbows, and shins, Velvety, smooth skin that easily bruises, Wounds are slow to heal and often leave wide scars. […] Vascular EDS is a unique type of EDS, and it is the most severe of them all. It affects blood vessels and internal organs; these can cause them to split and lead to life-threatening bleeding. Symptoms include: Thin skin that shows small blood vessels, especially on the legs and uppers chests, Skin that bruises easily, Blood arteries are delicate and can bulge or tear, resulting in severe internal bleeding, Hypermobile toes and fingers, unusual facial features (like thin lips and nose, small earlobes, and large eyes), and delayed wound healing, A possibility of organ issues, such as partial lung collapse, intestine tears, and womb tearing in late pregnancy.

• #42 Symptoms of Vascular Ehlers-Danlos syndrome – The VEDS Movement

  https://thevedsmovement.org/veds/how-is-the-body-affected/

  Joint pain may be present […] Congenital hip dislocation […] Congenital clubfoot […] Suspected increase in relative frequency of muscle and tendon rupture […] Sudden lung collapse, (pneumothorax) may be due to rupture of pulmonary blebs. This is usually an early manifestation. […] The uterus may rupture, particularly during the third trimester of pregnancy. […] The most common complication is spontaneous rupture of the colon, usually the sigmoid colon. […] May be thin, and the veins may be visible in some people. […] Prone to tearing and easy bruising. […] Gum fragility with bleeding after brushing or flossing […] Renal artery dissection may lead to reduced blood flow, loss of renal parenchyma (functional parts of the kidney), and renal hypertension.

• #43 FDNA™ Facial Features of Ehlers-Danlos Syndrome: Key Characteristics

  https://fdna.com/health/resource-center/ehlers-danlos-facial-features/

  Hypermobile Ehlers-Danlos presents with very similar symptoms to the classic form of the syndrome loose joints, susceptibility to bruising, muscle pain and fatigue, and heart valve issues. This form of the syndrome also includes degenerative joint disease that can be quite severe, as well as generalized chronic pain. […] Another main form of Ehlers-Danlos is known as the vascular type. This presents with serious health and medical conditions that are unique to this form of the syndrome. It shares some skin-related symptoms thin and transparent skin, for example, and heart valve issues. However, it also has unique symptoms and especially characteristic facial features a thin nose, protruding, prominent eyes, thin lips, sunken cheeks, and a small chin. Other conditions related to the syndrome include potentially collapsed lungs and fragile blood vessels.

• #44 SPOTLIGHT ON EHLERS-DANLOS SYNDROME: SYMPTOMS, DIAGNOSIS, AND TREATMENT | Mya Care

  https://myacare.com/blog/spotlight-on-ehlersdanlos-syndrome-symptoms-diagnosis-and-treatment

  Other common EDS symptoms pertain to the skin and vascular system, which are classically elongated, weaker and prone to tearing in those with the condition. Weaker blood vessels typically impact other organs as well, causing tissue or organ fragility and a variety of generalized symptoms. The most commonly affected organs are the intestines, uterus, bladder, and lungs. […] General EDS symptoms include: Joint stiffness, pain, swelling or dislocation; Fragile skin that can extend beyond the normal range (skin hyperextensibility); Deformities; Excessive bruising and scarring; Skin rashes or conditions like eczema and dermatitis; Unusually exposed veins through translucent skin; Varicose veins; Increased susceptibility to infections; Headaches and migraines; Tendency for bleeding; Nosebleeds and bleeding gums; Abdominal pain, bloating or gas; Constipation and diarrhea; Nausea and vomiting; Shortness of breath and chest pain; Coughing up blood; Urinary incontinence; Pelvic pain; Menstrual irregularities.

• #45 Ehlers-Danlos syndromes

  https://www.nhs.uk/conditions/ehlers-danlos-syndromes/

  Kyphoscoliotic EDS (kEDS) is rare. People with kEDS may have: curvature of the spine this starts in early childhood and often gets worse in the teenage years, joint hypermobility, loose, unstable joints that dislocate easily, weak muscle tone from childhood (hypotonia) this may cause a delay in sitting and walking, or difficulty walking if symptoms get worse, fragile eyes that can easily be damaged, soft, velvety skin that is stretchy, bruises easily and scars. […] It’s important to be careful about activities that put a lot of strain on your joints or put you at risk of injury. But it’s also important not to be overprotective and avoid living an otherwise normal life. […] The severity of the condition can vary within the same family.

• #46 Ehlers-Danlos Syndrome is an invisible condition

  https://hdsunflower.com/uk/insights/post/ehlers-danlos-syndrome-eds

  Kyphoscoliosis is another rare type of EDS. Symptoms include: Spine curvature this develops in early childhood and frequently gets worse in adolescence, Weak muscles, Hypermobility of joints, Unstable, loose joints that dislocate easily, Fragile eyes that easily get damaged, Velvety, soft, and stretchy skin that bruises easily and leaves scars, Difficulty in sitting and walking.

• #47 Nutritional Considerations for Hypermobile Ehlers-Danlos Syndrome – Practical Gastro

  https://practicalgastro.com/2024/06/17/nutritional-considerations-for-hypermobile-ehlers-danlos-syndrome/

  POTS is a form of dysautonomia affecting approximately 30% of people with hEDS/HSD. It is characterized by an increase in heart rate of 30 beats per minute (bpm) in adults (40 bpm for adolescents) in the first 10 minutes when moving from a recumbent to a standing position. Patients must have symptoms of orthostatic intolerance, such as palpitations, concentration difficulties, abnormal fatigue, presyncope, or headache for 3 or more months without another explanation. […] Patients with GI disorders are at increased risk for developing ED and patterns of disordered eating. There is a bi-directional relationship where GI symptoms can lead to food restriction and restriction exacerbates GI symptoms.

• #48 Autonomic dysfunction

  https://www.ehlers-danlos.org/information/autonomic-dysfunction/

  There are three typical conditions described: orthostatic hypotension (OH), orthostatic intolerance (OI), and postural tachycardia syndrome (PoTS). […] The symptoms can often be successfully managed with the simple remedies of increasing water and salt intake, and support stockings. Exercise to improve muscle re-conditioning and heart condition is also important.

• #49 Cognitive and Psychopathological Aspects of Ehlers-Danlos Syndrome – Experience in a Specialized Medical Consultation

  https://www.gavinpublishers.com/article/view/cognitive-and-psychopathological-aspects-of-ehlersdanlos-syndrome-experience-in-a-specialized-medical-consultation

  Pain is mainly articular and periarticular (95% of 853 cases). It is a peculiar way for people to be, to exist. The whole body is painful. To the question „where do you hurt?”, the answer is: „I hurt everywhere”. There is also fatigue (97% of 853 cases), often very intense, which is put on account of laziness. Quickly breathless (82%), patients are uncertain on legs whose ankles easily twist. Knees recede, hips sometimes block. Patients also hit doorframes and tables corners, drop objects because of dysproprioception. The multiplicity of somatic clinical manifestations is surprising and is all too often related to behavioral disorders. Usual thermoregulation disorders (80%) result in discomforts that entourage misunderstands. Sensitivity to cold or, on the contrary, flushing, sweating unrelated to the outside temperature is often observed (73%).

• #50 Ehlers-Danlos Syndromes: Symptoms, Treatment, and Types

  https://patient.info/bones-joints-muscles/ehlers-danlos-syndrome-leaflet

  An uncomfortable feeling of thudding of the heart (palpitations) and a faster heart rate are seen in hypermobile EDS. […] Asthma-like symptoms can occur in some forms of EDS. […] Constipation and diverticulosis (in which there are bulges in the wall of the large intestine) are more common in people with EDS. […] Children with EDS often show delay in crawling, walking and standing. […] Prolapse of the womb (uterus) is more common in EDS. […] The outlook (prognosis) is variable and depends on the type of EDS. Most forms of EDS do not affect a person’s lifespan and people with milder symptoms are able to live their lives without any restrictions. […] Many people with EDS have more severe symptoms and may have significant disabilities and therefore a severe restriction of their lives. […] If someone has the rare type of EDS that affects the blood vessels (the vascular type) then there is a risk of bursting (rupture) of large blood vessels or internal organs, and therefore premature death.

• #51 Classic Ehlers-Danlos Syndrome (cEDS) – Ehlers-Danlos Syndromes New Zealand

  https://ehlers-danlos.org.nz/ceds/?srsltid=AfmBOor6HrFmT4cwObv39vHNdIDBFtYWocLZTduzMT7bQ11EJsbUprnJ

  Gastrointestinal complaints are more commonly described in the hypermobile type of EDS, although they can be present in patients with classical EDS and may include: Dysphagia, Dyspepsia, Reflux disease with or without hiatal hernia, Irritable-bowel disease-like symptoms, Unspecified abdominal pain, Defecatory dysfunctions (constipation, diarrhea), and rectocele.

• #52 Nutritional Considerations for Hypermobile Ehlers-Danlos Syndrome – Practical Gastro

  https://practicalgastro.com/2024/06/17/nutritional-considerations-for-hypermobile-ehlers-danlos-syndrome/

  Gastrointestinal disorders are among the most common manifestations of hEDS/HSD, with studies reporting ~90% of patients experience symptoms of diseases of gut-brain interaction (DGBIs). GI symptoms may include dysphagia, reflux, postprandial fullness, bloating, abdominal pain, nausea, vomiting, diarrhea, and constipation. Patients often attribute symptoms to eating, which can generate food fears and changes in appetite that impact nutritional intake and contribute to disordered eating patterns. […] Research suggests that up to 62% of people with hEDS/HSD are diagnosed with a subtype of IBS (IBS-diarrhea, IBS-constipation, IBS-mixed, IBS-undefined). Using the ROME IV criteria, IBS is characterized by the presence of recurrent abdominal pain one day a week or more for at least 3 months and the presence of at least two symptoms related to defecation, a change in stool frequency and/or form.

• #53 13 Ehlers-Danlos Syndrome Clues I Missed – Patient Worthy

  https://patientworthy.com/2018/03/28/12-things-i-had-no-idea-were-ehlers-danlos-syndrome-2/

  Gastrointestinal problems are often overlooked in the world of EDS, but 56% of patients experience them. […] Honestly, I could list a hundred weird symptoms, but like many other EDS patients who suffer from fatigue, I’m actually three sleepy toddlers standing on each other’s shoulders in a trench coat, bye.

• #53 13 Ehlers-Danlos Syndrome Clues I Missed – Patient Worthy

  https://patientworthy.com/2018/03/28/12-things-i-had-no-idea-were-ehlers-danlos-syndrome-2/

  I lived with Ehlers-Danlos syndrome (EDS), a rare connective tissue disorder, my whole life and had no idea until I was 21. The symptoms were all so random, separate, and often so seemingly inconsequential, that I never suspected they were related symptoms, just the ~quirks~ that come along with having a human body. […] In reality, the condition is so much more than being really double-jointed– it literally affects every organ system in the body. Since it’s so rare, it can slip under the radar easily, leaving potentially life-threatening complications to go unmonitored. […] There is evidence that exercise can prevent these type of injuries in people with EDS– to learn about how to work out safely, click here. […] EDS actually causes Raynaud’s disease, which causes bodily extremities to respond severely to cold in a lot of patients.

• #54 Nutritional Considerations for Hypermobile Ehlers-Danlos Syndrome – Practical Gastro

  https://practicalgastro.com/2024/06/17/nutritional-considerations-for-hypermobile-ehlers-danlos-syndrome/

  Common gastroparesis symptoms include changes in appetite, nausea, vomiting, early satiety, and unintentional weight loss. A large case-control study compared hospitalized patients with and without EDS and found patients with EDS exhibited a 12.26 higher odds ratio of a concurrent diagnosis of gastroparesis. […] Constipation is common; a recent study found 73% of patients with hEDS/HSD had constipation versus 16% of controls. The underlying etiology of constipation in hEDS/HSD is multifactorial and includes DGBIs, delayed motility, small intestinal methane overgrowth, pelvic floor dyssynergia, medication induced constipation, and rectal hyposensitivity. […] One small study found that 16% of people with hEDS/HSD also had celiac disease. A large case control study determined the rate of celiac disease was 5.5 times higher in people with EDS than the average hospitalized patient.

• #55 Ehlers Danlos Syndrome and Gastroparesis

  https://edsnutrition.com/ehlers-danlos-syndrome-and-gastroparesis/

  Ehlers-Danlos Syndrome is considered a connective tissue disorder. Multiple connective tissue disorders can fall under the term “Ehlers-Danlos Syndrome”. The most common subtype of Ehlers-Danlos Syndrome is hypermobile Ehlers-Danlos Syndrome (hEDS). People with hEDS often have hypermobile joints, chronic pain, and a variety of symptoms that can affect multiple body systems, including the gastrointestinal tract. […] Common Ehlers-Danlos Syndrome symptoms: Joint hypermobility (fingers, knees, elbows that can go “backward”); Joint pain; Unstable joints that “slip out” or even dislocate; Fragile skin and/or skin that bruises easily; Digestive issues like constipation, nausea, acid reflux, etc.; Fatigue. […] Scientists have not determined if there’s a connection between Ehlers-Danlos Syndrome and gastroparesis yet. However, current research suggests that about 30% of people with hypermobility disorders have upper gastrointestinal digestive symptoms. People with hypermobility disorders (like EDS) experience digestive issues more frequently than other people, so it’s likely that future research will help us understand how connective tissue disorders are linked to digestive issues.

• #56 EDS Symptoms and Treatment | Bladder & Bowel Community

  https://www.bladderandbowel.org/associated-illness/ehlers-danlos-syndrome/

  Each separate disorder comes with its own unique symptoms, which can vary from being relatively mild and manageable to becoming life-threatening. All EDS conditions can be characterised by these distinct Ehlers Danlos Syndrome symptoms including: […] People who have been diagnosed with Hypermobile EDS may also experience bladder and bowel problems such as stress or urgency incontinence or intestinal dysmotility. […] Bowel problems are more common than bladder disorders, especially in those with Hypermobile EDS. The connective tissues are vital in the performance of peristalsis, which is the movement needed in the bowel to expel waste in the body. […] Any abnormalities in the connective tissues can disrupt how the bowel works leading to motility issues and constipation, plus in extreme cases paralysis of the digestive tract known as gastroparesis. […] Sometimes rectal and genital prolapse can occur, which can interfere with the ability to pass a bowel motion.

• #57 Ehlers-Danlos Syndrome | Doctor

  https://patient.info/doctor/ehlers-danlos-syndromes

  Intestinal tract: unexplained abdominal pain, IBS, constipation. In some types diverticulae, constipation or rupture, rectal prolapse. People may be more than usually prone to nausea and to travel sickness. […] Musculoskeletal: in some types herniation, hypotonia, delayed motor development. In some types kyphoscoliosis, dental abnormalities. […] Ocular: in some types abnormalities of the globe and cornea. […] Hearing: tinnitus due to lax support to the ear ossicles. […] Urogynaecological: uterocervical prolapse, obstetric complications – particularly morning sickness, early membrane rupture, precipitate labour, and perineal and vaginal trauma. In the rare vascular type, pregnancy can lead to uterine rupture. […] Systemic: tiredness, fatiguability, sleep disturbance. These symptoms, whilst not required for diagnosis, are often dominant and can be debilitating. […] Psychological: anxiety, depression. […] Dental: chronic temporomandibular dislocation is common. […] The specific presentation patterns and their severity vary both between subtypes and within subtypes. They are described in more detail below.

• #57 Ehlers-Danlos Syndrome | Doctor

  https://patient.info/doctor/ehlers-danlos-syndromes

  Most types of EDS present with symptoms affecting skin and joints. However, many systems can be affected. This varies with the subtype but clinical features can include: […] Chronic widespread pain is common among EDS patients. […] Skin: varying degrees of increased skin elasticity and fragility, bruising easily, scars tending to widen. Splitting may occur easily, particularly on the forehead, knees and elbows. […] Joints: laxity and hypermobility, pes planus. Spontaneous dislocations and subluxations may occur, most often involving the fingers, elbows, shoulders and patellae. Reduction is usually easy and patients can often do it themselves. […] Cardiovascular: dizziness, palpitations, dysautonomia. […] There are occasional heart valve abnormalities; in the rare vascular subtype major vascular rupture is life-threatening.

• #58 Systemic manifestations of Ehlers-Danlos syndrome

  https://pmc.ncbi.nlm.nih.gov/articles/PMC7785142/

  About 30% of patients in this study had been diagnosed with at least one cardiac condition, the most common being arrhythmia (23%), aortic root dilatation (15%), and valvular anomalies (9%). […] TMJ dysfunction is often present in conjunction with other findings such as friable/sensitive oral mucosa, absent frenulum, periodontitis, or abnormally shaped teeth. […] Mast cell activation syndrome can present as flushing, pruritus, hypotension, asthma, diarrhea, bloating, and cramping. […] In conclusion, EDS is a complex multidisciplinary condition. While the most common symptoms are musculoskeletal, many serious clinical features are systemic. Often, this disease is suspected only when evaluating the pattern of symptoms across multiple body systems. These symptoms may be insidious and misdiagnosed. Delay in diagnosis makes management of this condition difficult; therefore, early diagnosis is particularly important.

• #59 EDS Info – Ehlers-Danlos Syndromes New Zealand

  https://ehlers-danlos.org.nz/eds-info/?srsltid=AfmBOorn0K470Ykrg9b5mbU0g41vxYyqpPDC6pbdJ2b6wp_kZoEuoqyu

  Soft velvety-like skin; stretchy skin (most associated with Classical EDS); fragile skin that tears or bruises easily (bruising may be severe); severe or unusual scarring; slow and poor wound healing. […] Chronic, debilitating musculoskeletal pain (especially associated with Hypermobile EDS); fatigue/tiredness; gastrointestinal problems (Irritable Bowel Syndrome, etc); mitral valve prolapse, and heart arrhythmia, scoliosis; hernias; poor response to local anaesthetic; arterial/intestinal/uterine fragility or rupture (life threatening and most commonly associated with Vascular EDS). […] Types and severity of symptoms vary for each individual. Although some EDS symptoms can appear in infancy or early childhood, it is more common to start noticing symptoms from the teenage years. Joint pain and dislocations/subluxations are often the first symptoms that start requiring attention.

• #60 What Causes Ehlers Danlos Syndrome? | Marfan Foundation

  https://marfan.org/conditions/ehlers-danlos/

  Ehlers-Danlos syndrome is a diverse connective tissue condition that has thirteen different subtypes. This group of genetic connective tissue conditions is commonly characterized by unstable, hypermobile joints, loose, stretchy skin, and fragile tissues. […] However, some subtypes, such as Vascular Ehlers-Danlos and Kyphoscoliotic Ehlers-Danlos, are prone to life-threatening arterial dissections and ruptures. […] The 13 types of Ehlers-Danlos syndromes have a significant overlap in many features. Characteristics can range from mild symptoms, such as loose or hypermobile joints, to severe symptoms, such as pain, functional bowel disorders, incisional hernias, and arterial dissections and ruptures. […] Hypermobile EDS is characterized primarily by joint hypermobility affecting both large and small joints, which may lead to recurrent joint dislocations and subluxations (partial dislocation). In general, people with this type have soft, smooth and velvety skin with easy bruising and chronic pain of the muscles and/or bones.

• #61 Ehlers-Danlos Syndrome: Signs and Symptoms

  https://www.health.com/ehlers-danlos-syndrome-symptoms-8406578

  Fatigue and sleep problems: Exhaustion that doesn’t improve with rest or sleep disturbances, such as insomnia, restlessness, non-restorative sleep, and disrupted sleep patterns. […] Digestive problems: Constipation, nausea, and vomiting. […] Vertigo: Dizzy spells, or a sensation of a spinning room even when lying down or sitting still. […] Feet abnormalities: Low arches or flat feet. […] Acrocyanosis: Painless, persistent discoloration (bluish-colored) of the hands, fingers, feet, and toes. […] People with hEDS may also experience: Arrhythmia (irregular heartbeat). […] Depression. […] Migraine. […] Malabsorption (trouble absorbing certain nutrients from foods). […] Soft, thin skin. […] Though rare, hEDS can sometimes also cause enlarged gums, smaller teeth, abdominal hernias, irregular menstrual cycles, and gastroesophageal reflux disease (GERD).

• #62 Does EDS get worse as you age? – The Fibro Guy

  https://www.thefibroguy.com/blog/does-eds-get-worse-as-you-age/

  EDS doesn’t progress the same way for everyone, and that’s part of what makes it such a challenging condition to navigate. While some people report that they actually feel better as they get older, particularly if they’ve focused on building muscle strength and managing symptoms proactively, others experience a steady worsening of their symptoms, especially if they’ve gone years without a proper diagnosis or effective treatment plan. […] The way EDS progresses depends on the specific genetic mutation, the degree of joint instability, and the involvement of other body systems. […] Vascular EDS is often the most concerning in terms of age-related progression. […] Research shows that by age 40, nearly 80% of individuals with vEDS experience arterial dissections or aneurysms. […] For those with vEDS, pregnancy carries significant risks, with a maternal mortality rate of around 5% due to uterine rupture.

• #63 Does EDS get worse as you age? – The Fibro Guy

  https://www.thefibroguy.com/blog/does-eds-get-worse-as-you-age/

  In fact, pain, fatigue, and musculoskeletal issues often increase as the body tries to compensate for unstable joints. […] Over time, the accumulation of microtrauma can lead to early onset osteoarthritis, chronic pain syndromes, and widespread muscle tension as the body works overtime to stabilize itself. […] But it’s not just the musculoskeletal system that’s affected, many people with EDS find that systemic issues become more pronounced with age. Dysautonomia, often seen in conditions like Postural Orthostatic Tachycardia Syndrome (POTS) can worsen, leading to greater difficulties with temperature regulation, blood pressure instability, and fatigue. […] For those with vascular EDS (vEDS), the risk of arterial rupture and life-threatening complications increases over time, making early monitoring and intervention essential.

• #64 Top 10 Most Common Hypermobility Symptoms – Kate Skinner PT

  https://www.kateskinnerpt.com/hypermobility-symptoms

  Weak collagen throughout your body makes you more susceptible to injury, particularly injuries to your muscular-skeletal system. […] Hypermobility syndrome often comes with digestive disorders. […] In some cases, hypermobility syndrome results in skin that’s thin, stretchy, or saggy. […] Scoliosis due to hypermobility syndrome can wreak havoc on your spinal health. […] Lax joints, weak connective tissue, and poor posture often cause balance and coordination problems in hypermobility syndrome.

• #64 Top 10 Most Common Hypermobility Symptoms – Kate Skinner PT

  https://www.kateskinnerpt.com/hypermobility-symptoms

  Hypermobility syndrome is caused either by injury or by inherited genetic defects which negatively impact your body’s production of collagen. […] All three present a cluster of hypermobility symptoms that range from mild to crippling. Some symptoms are common to all three, while others are more specific. […] If you have hypermobility syndrome, the joints most likely to hurt are your shoulders, knees, wrists, elbows, and fingers. […] Painful and recurrent headaches are a common symptom of hypermobility. […] Hypermobility sufferers are prone to easy dislocation of their joints. Dislocation means joints pop out of their sockets. This can cause you severe pain. Dislocation is especially common if you have Ehlers-Danlos Syndrome (EDS). […] Chronic fatigue is symptomatic of many different diseases and disorders, including hypermobility syndrome. Pain and stiffness may result in poor sleep and tiredness.

• #65 Ehlers-Danlos Syndromes – Children’s Health Issues – Merck Manual Consumer Version

  https://www.merckmanuals.com/home/children-s-health-issues/connective-tissue-disorders-in-children/ehlers-danlos-syndromes

  Ehlers-Danlos syndromes are rare hereditary disorders of connective tissue that result in unusually flexible joints, very elastic skin, and fragile tissues. […] Typical symptoms include flexible joints, a humpback, flat feet, and elastic skin. […] People with an Ehlers-Danlos syndrome usually have very flexible joints, abnormal scarring, poor wound healing, fragile blood vessels, and very elastic skin. The skin can be stretched up to several inches but returns to its normal position when released. […] Ehlers-Danlos syndromes may alter the body’s response to injuries. Minor injuries may result in wide gaping wounds. […] Most adults have flat feet. […] Despite the many and varied complications people with an Ehlers-Danlos syndrome may have, their life span is usually normal. […] However, potentially fatal complications (usually bleeding) occur in certain types.

• #66 The Natural Approach to Treat Ehlers-Danlos Syndrome –

  https://caringmedical.com/home/conditions/natural-approach-treat-ehlers-danlos-syndrome/

  Common manifestations of EDS include: Joint hypermobility, Recurring joint dislocations, Arthralgia (joint pain), Skin abnormalities including: Significant hyperelasticity (stretchability), Thin, transparent skin, Easy bruising, Poor wound healing, Atrophic „cigarette paper” scars. […] EDS is often a progressive disorder, especially when a joint becomes unstable. […] When the joint instabilities from EDS are not treated appropriately, they progress to the point of significant disability, including an inability to walk and do simple activities of daily living (caring for oneself). […] EDS manifestations, especially joint instability, if not addressed early can lead to progressive daily disabling pain. […] While no cure has yet has been found for the underlying collagen defect that leads to the various subtypes of EDS, the joint instability, joint dislocations, subluxations, progressive joint degeneration and disabling pain can be successfully treated with Prolotherapy. […] The most important and serious of the joint instabilities caused by EDS to recognize in our opinion is cervical (neck) instability. […] Besides POTS and MCAS, cervical instability can cause a host of „diagnoses,” syndromes and symptoms.

• #67 Ehlers-Danlos Syndromes: Symptoms, Treatment, and Types

  https://patient.info/bones-joints-muscles/ehlers-danlos-syndrome-leaflet

  Dislocations of joints may easily occur, and people with EDS can often put their own joints back into place because the tissues are so stretchy. Joint pains are also common. […] In all types of EDS except the vascular type, the skin feels soft and is unusually stretchy. […] Many affected people find that their skin splits and bruises easily and that skin injuries heal slowly. […] The muscles of people with many forms of EDS tend to be floppier and less strong than those of people without EDS. […] Tiredness, getting tired easily after physical activity (fatiguability) and dizziness are very common in EDS of many types. Sleep disorders are also common. […] Widespread pain or pain in the limbs is a common feature of most types of EDS. […] Difficulties with mood, particularly anxiety, panic disorder and depression, are common conditions in the general population but they are more commonly experienced by people with EDS.

• #68 Shining a light on a ‘Complicated’ disease: Ehlers-Danlos syndrome | MUSC | Charleston, SC

  https://web.musc.edu/about/news-center/2025/03/31/shining-a-light-on-a-complicated-disease-ehlers-danlos-syndrome

  EDS, a group of heritable connective tissue disorders, affects the body’s collagen the protein that provides strength and structure to skin, joints, blood vessels and organs. […] For many living with hEDS, the hardest battle isn’t just the chronic pain or joint dislocations it’s what they see as the years of medical gaslighting. On average, it takes 15 years to receive a diagnosis, with patients cycling through countless rounds of doctors, being misdiagnosed and receiving anxiety labels or vague explanations for their debilitating symptoms. […] While it can manifest as chronic, debilitating pain; gastrointestinal issues like IBS and gastroparesis; endometriosis; chronic fatigue; and pregnancy complications, it’s also frequently linked to co-occurring conditions like postural orthostatic tachycardia syndrome (POTS), mast cell activation disease (MCAD) and vision and dental issues.

• #69 Ehlers-Danlos Syndrome | University Hospitals

  https://www.uhhospitals.org/health-information/health-and-wellness-library/article/diseases-and-conditions/ehlers-danlos-syndrome

  There is no cure for EDS. Care is focused on easing symptoms, such as joint pain. Your healthcare providers will also talk with you about how you can prevent future health problems. These include joint dislocation and poor wound healing. […] For people who have severe symptoms, surgery or other treatments may be needed. This can include surgery for a dislocated joint or a ruptured blood vessel. […] EDS can cause complications, such as: Joint dislocation, Early onset of arthritis, Tear or rupture of an organ, Heart valve or blood vessel problems, Physical disability due to muscle and joint problems, Poor wound healing, Mental health problems like depression. […] EDS is a lifelong disease. But you can take steps to prevent problems linked to EDS. Make sure you see your healthcare team for regular checkups and tests. Keep in mind that poor wound healing can delay recovery after dental and medical procedures.

• #70 Cognitive and Psychopathological Aspects of Ehlers-Danlos Syndrome – Experience in a Specialized Medical Consultation

  https://www.gavinpublishers.com/article/view/cognitive-and-psychopathological-aspects-of-ehlersdanlos-syndrome-experience-in-a-specialized-medical-consultation

  Patients with Ehlers-Danlos Syndrome (EDS) and doctors have great difficulty understanding each other. Average duration of patients’ wandering is 22 years between the onset of the first recognized signs and diagnosis. Pain, mainly joint pain (95%) is a constant state for some patients. Tiredness (97%), often very intense, is linked to laziness. Multiplicity of somatic clinical manifestations is surprising, and symptoms are all too often attributed to behavioral disorders. Working memory, attention, concentration and orientation problems are frequent and very often considered as psychiatric symptoms. Anxiety and hyperemotivity are usual. Dystonia (57% of cases) is responsible for worsening pain, joints and muscular disorders with sometimes impressive pseudo epileptic attacks of muscular contractions. Pseudo-paralysis, usually regressive, associated with proprioceptive disorders, can also be observed.

• #71 EDS Prognosis | Ehlers-Danlos NewsEnvelope icon

  https://ehlersdanlosnews.com/eds-prognosis/

  Ehlers-Danlos syndrome (EDS) refers to a group of disorders that affect the cartilage and connective tissue — the tissue that gives organs shape and structure. […] The prognosis of EDS varies greatly depending on the specific type of EDS a patient has. […] The most common types of EDS (classical, classical-like, and hypermobile) do not greatly affect life expectancy. However, symptoms may become more severe as patients age and joints that have been dislocated multiple times become painful. […] In EDS patients with hypermobile joints, weakening bones can make the symptoms of the disease more severe as it progresses. Bones and joints that were previously dislocated may also break more often. […] The severe forms of EDS (vascular and cardiac-valvular) can affect lifespan. In these types of EDS, the blood vessels can become weak and easily damaged. Even standing up can cause an internal rupture of blood vessels, and in severe cases, the disease can be life-threatening. Most vascular EDS patients have had a severe event by the time they are 40.

• #72 Ehlers–Danlos syndrome – Wikipedia

  https://en.wikipedia.org/wiki/Ehlers%E2%80%93Danlos_syndrome

  Although all types of EDS are potentially life-threatening, most people have a normal lifespan. Those with blood vessel fragility, though, have a high risk of fatal complications, including spontaneous arterial rupture, which is the most common cause of sudden death. The median life expectancy in the population with vascular EDS is 48 years.

• #73 What Is the Life Expectancy for Someone With Ehlers-Danlos Syndrome?

  https://www.emedicinehealth.com/ehlers-danlos_syndrome_life_expectancy/article_em.htm

  Ehlers-Danlos syndrome typically progress slowly, and the prognosis depends upon the type of EDS and the severity of the condition. […] Patients with the classical and hypermobility forms of Ehlers-Danlos syndrome have a normal life expectancy. […] About 80% of patients with vascular Ehlers-Danlos syndrome will experience a major health event by age 40 and the life expectancy is shortened, with an average age of death of 48 years. […] The lifespan of patients with the kyphoscoliosis type of EDS is decreased, due to the condition’s effects on the vascular system and the potential for restrictive lung disease.

• #74 Does EDS get worse as you age? – The Fibro Guy

  https://www.thefibroguy.com/blog/does-eds-get-worse-as-you-age/

  Aging with Ehlers-Danlos Syndrome (EDS) is a bit of a paradox. For some, hypermobility decreases over time as we retain less and less water, but that doesn’t always mean things get easier. Instead, pain, fatigue, and the many systemic complications often become more prominent in our lives. […] EDS isn’t a degenerative condition in the way that some like Parkinson’s is, but that doesn’t mean it stays the same. The reality is that aging with EDS is highly individual, shaped by genetics, lifestyle, and access to proper management, in the same way some may be more predisposed to EDS weight gain, and some to weight loss. […] While some people find relief as their joints stiffen as they age, others develop new challenges like osteoarthritis, cardiovascular issues, worsening autonomic dysfunction, or they may find EDS flare-ups increase.

• #75 What age does EDS usually start? – Ehlers Danlos Syndrome – Spero Clinic

  https://www.thesperoclinic.com/conditions/ehlers-danlos-syndrome/age-eds-start/

  The Ehlers-Danlos syndromes (EDS) are currently classified in a recognized system of thirteen subtypes. The age at which Ehlers-Danlos syndrome (EDS) symptoms appear varies depending on the subtype of EDS and the symptoms they suffer from, as EDS will present differently for each patient. […] Depending on the type of EDS and individual, symptoms can appear as early as infancy and as late as late adulthood. For example, Classical EDS (cEDS): Symptoms often appear in childhood or adolescence. However, the diagnosis is often delayed until adulthood due to milder symptoms. […] Hypermobile EDS (hEDS): Symptoms often appear in childhood or adolescence. However, the diagnosis is often delayed until late adulthood due to subtle signs and challenges with diagnostic tools for assessing generalized joint hypermobility (GJH).

• #76 Ehlers-Danlos syndrome: MedlinePlus Medical EncyclopediaLock

  https://medlineplus.gov/ency/article/001468.htm

  Ehlers-Danlos syndrome (EDS) is a group of inherited disorders marked by extremely loose joints, very stretchy (hyperelastic) skin that bruises easily, and easily damaged blood vessels. […] Symptoms of EDS vary by type and may include: Back pain, Double-jointedness, Easily damaged, bruised, and stretchy skin, Easy scarring and poor wound healing, Flat feet, Increased joint mobility, joints popping, early arthritis, Joint dislocation, Joint pain, Premature rupture of membranes during pregnancy, Very soft and velvety skin, Vision problems. […] People with EDS generally have a normal life span. Intelligence is normal. Those with the rare vascular type of EDS are at greater risk for rupture of a major organ or blood vessel. These people have a high risk for sudden death. […] Possible complications of EDS include: Chronic joint pain, Early-onset arthritis, Failure of surgical wounds to close (or stitches tear out), Premature rupture of membranes during pregnancy, Rupture of major vessels, including a ruptured aortic aneurysm (only in vascular EDS), Rupture of a hollow organ such as the uterus or bowel (only in vascular EDS), Rupture of the eyeball (only in vascular EDS).

• #77 Ehlers–Danlos syndrome – Wikipedia

  https://en.wikipedia.org/wiki/Ehlers%E2%80%93Danlos_syndrome

  The prognosis depends on the specific disorder. Excess mobility was first described by Hippocrates in 400 BC. […] The outcome for individuals with EDS depends on the specific type of EDS they have. Symptoms vary in severity, even in the same disorder, and the frequency of complications varies. Some people have negligible symptoms, while others are severely restricted in daily life. Extreme joint instability, chronic musculoskeletal pain, degenerative joint disease, frequent injuries, and spinal deformities may limit mobility. Severe spinal deformities may affect breathing. In the case of extreme joint instability, dislocations may result from simple tasks such as rolling over in bed or turning a doorknob. Secondary conditions such as autonomic dysfunction or cardiovascular problems, occurring in any type, can affect prognosis and quality of life. Severe mobility-related disability is seen more often in hEDS than in classical EDS or vascular EDS.

• #78 Ehlers-Danlos Syndrome – Rheumatology Advisor

  https://www.rheumatologyadvisor.com/ddi/ehlers-danlos-syndrome/

  Patients with Ehlers-Danlos syndrome can develop serious complications, including major articular complications such as subluxation and dislocation of the joints (shoulder, patella, digits, hip, radius, and clavicles) and chronic joint and limb pain. Individuals with a severe form of classic Ehlers-Danlos syndrome or vascular Ehlers-Danlos syndrome could experience life-threatening rupture of large arteries, intracranial aneurysms, and arteriovenous fistulas. Individuals with classic Ehlers-Danlos syndrome may experience mitral valve prolapse, tricuspid valve prolapse, and other cardiac manifestations due to structural malformations. Women with classic Ehlers-Danlos syndrome who are pregnant have a higher risk of vaginal and perineal lacerations, extension of episiotomy incisions, and prolapse of the uterus or bladder.

• #79 Ehlers-Danlos syndrome – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/ehlers-danlos-syndrome/diagnosis-treatment/drc-20362149

  Extremely loose joints, fragile or stretchy skin, and a family history of Ehlers-Danlos syndrome are often enough to make a diagnosis. […] There is no cure for Ehlers-Danlos syndrome, but treatment can help you manage your symptoms and prevent further complications. […] Joints with weak connective tissue are more likely to dislocate. Exercises to strengthen the muscles and stabilize joints are the primary treatment for Ehlers-Danlos syndrome. […] Surgery may be recommended to repair joints damaged by repeated dislocations, or to repair ruptured areas in blood vessels and organs. However, the surgical wounds may not heal properly because the stitches may tear through the fragile tissues. […] If you have Ehlers-Danlos syndrome, it’s important to prevent injuries. […] Knowing more about Ehlers-Danlos syndrome can help you take control of your condition. […] Are any of your joints overly flexible? […] Is your skin extra stretchy? […] Does your skin heal poorly after injuries?

• #80 Ehlers-Danlos Syndrome: Symptoms, Diagnosis, Treatment

  https://www.webmd.com/a-to-z-guides/ehlers-danlos-syndrome-facts

  Other symptoms include: Dental issues such as tooth crowding or bleeding gums, Painful joints, Feeling tired even after you rest, Trouble focusing, Headaches, Flat feet, Muscle weakness, especially in cold temperatures, Loss of bladder control (trouble holding your pee), Dizziness, Digestive issues (such as feeling bloated or gassy often). […] Based on the type of EDS you have, you could experience health issues such as: Chronic joint pain. You may also have severe muscle aches. Dislocated joints. You could have a bone pop fully out of a joint, or just halfway. Some people with EDS experience this every day. […] Ehlers-Danlos Syndrome is a lifelong condition. You’ll need to manage your symptoms and take extra steps to prevent injuries. Working closely with your doctor is key to a healthy life.

• #81 Shining a light on a ‘Complicated’ disease: Ehlers-Danlos syndrome | MUSC | Charleston, SC

  https://web.musc.edu/about/news-center/2025/03/31/shining-a-light-on-a-complicated-disease-ehlers-danlos-syndrome

  Maitland identified two challenges in the care of children and adults with EDS. First, the severity and range of symptoms vary widely from patient to patient. This, coupled with limited provider education and a health care system not equipped to treat those who don’t fit neatly into diagnostic categories, often leaves patients without meaningful care. […] These patients often endure years of pain, misdiagnoses and dismissal before they find answers, said Patel.

• #82 What Causes Ehlers Danlos Syndrome? | Marfan Foundation

  https://marfan.org/conditions/ehlers-danlos/

  Vascular EDS is characterized by thin, translucent skin that is extremely fragile and bruises easily. Arteries and certain organs such as the intestines and uterus are also fragile and prone to rupture. […] Treatment is based on a persons specific set of symptoms. Options may include physical therapy/rehabilitation, assistive devices, pain medication to help relieve joint pain, and arterial imaging.

• #83 Symptoms and Signs of Ehlers-Danlos Syndrome | Neurological Surgery

  https://neurosurgery.weillcornell.org/condition/ehlers-danlos-syndrome-eds/symptoms-and-signs-ehlers-danlos-syndrome

  Ehlers-Danlos Syndrome (EDS) is a complex condition that affects many parts of the body. Signs and symptoms, and their severity, vary widely even for those in the same family. […] EDS may manifest simply as extra-flexibility in one person, while in another it may cause damage to the nervous system and result in debilitating pain. […] Symptoms and signs of types of Ehlers-Danlos Syndrome include, but are not limited to: Abnormal wound healing, Arthritis, Back pain and degenerative disc disease, Cardiovascular abnormalities, Chronic fatigue, Congenital clubfoot, Cervicocranial instability, Delayed motor development, Double-jointedness, Easy scarring and poor wound healing, Fragile arteries, prone to rupture, Frequent injuries (related to unstable joints), Increased joint mobility, joints popping, Joint dislocation, Joint hypermobility that leads to frequent dislocations and partial dislocations, Joint pain (arthralgia), Migraines, Muscle pain (myalgia), Musculoskeletal pain that is chronic and debilitating, Neurologic deficits (myelopathy), Numbness, Osteopenia (low bone density), Pins-and-needles feeling, Premature rupture of membranes during pregnancy, Problems with internal organs, such as mitral-valve prolapse or organ prolapse, restriction of lungs, Progressive kyphoscoliosis (kyphosis and scoliosis), present at birth or within the first year of life, Severe low/poor muscle tone (hypotonia) at birth, Spondylosis (degeneration in spine), Unusual skin: very soft and velvety; fragile, bruises easily; stretchy (hyperelastic), Vision problems: sclera (the white of the eye) fragility, unusually small corneas.

• #84 What is EDS?

  https://www.ehlers-danlos.org/what-is-eds/

  The Ehlers-Danlos syndromes (EDS) are a group of thirteen individual genetic conditions, all of which affect the body’s connective tissue. […] Individuals with the condition may also be able to extend their joints further than is usual this is known as being hypermobile, bendy or double-jointed. […] Symptoms commonly include, but are not limited to, long-term pain, chronic fatigue, dizziness, palpitations and digestive disorders. Such problems and their severity vary considerably from person to person, even in the same type of EDS and within the same family. […] Many children with EDS are 'mild’ and their symptoms may go unnoticed, however sometimes children are severely affected. A child with EDS might experience symptoms caused by their joint hypermobility, but many other parts of the body can also be affected, leading to difficulties in school. […] EDS cannot be 'cured’ but many people learn over time how to control it and live full and active lives. The day-to-day management of most types of EDS is based around the right kind of exercise, physiotherapy and pacing.

• #85 Ehlers–Danlos syndrome – Wikipedia

  https://en.wikipedia.org/wiki/Ehlers%E2%80%93Danlos_syndrome

  Symptoms often include loose joints, joint pain, stretchy velvety skin, and abnormal scar formation. These may be noticed at birth or in early childhood. Complications may include aortic dissection, joint dislocations, scoliosis, chronic pain, or early osteoarthritis. […] Diagnosis is often based on symptoms, particularly with hypermobile EDS (hEDS), but people may initially be misdiagnosed with hypochondriasis, depression, or myalgic encephalomyelitis/chronic fatigue syndrome. […] A cure is not yet known, and treatment is supportive in nature. Physical therapy and bracing may help strengthen muscles and support joints. Several medications can help alleviate symptoms of EDS such as pain and blood pressure drugs, which reduce joint pain and complications caused by blood vessel weakness.

• #86 Signs You Grew Up with Ehlers-Danlos Syndrome (EDS)

  https://www.painri.com/post/signs-you-grew-up-with-ehlers-danlos-syndrome-eds

  You werent just accident-proneyour joints were unstable, and your proprioception was off, making movement more difficult. […] Chronic pain made sitting in class unbearable, and you shifted constantly to find a comfortable position. […] Simple activities like reaching for something or rolling over in bed could cause a joint to pop out of place. […] Frequent urination, bladder pain, or incontinence were frustrating and embarrassing issues. […] Joint hypermobility, chronic pain, fragile skin, slow healing, digestive issues, dizziness, and fatigue are some of the most common symptoms. […] While theres no cure, physical therapy, bracing, pain management, and lifestyle adaptations can help manage symptoms.

• #87 What is Ehlers-Danlos Syndrome? How Do I Know If I Have It? – RTHM

  https://rthm.com/articles/what-is-ehlers-danlos-syndrome/

  Its important to note that there is no cure for EDS, so treatment focuses on symptom management and preventive measures to improve the quality of life for individuals with the condition. […] Chronic pain is often associated with EDS. Pain medications, such as nonsteroidal anti-inflammatory drugs (NSAIDs), acetaminophen, or in some cases, prescribed analgesics, may be used to manage pain. Its important to work closely with a healthcare provider to find the most effective and safe pain management strategy.

• #88 Empowering Awareness: Recognizing Ehlers-Danlos Syndrome Symptoms | Relief Now

  https://www.reliefnow.com/articles/ehlers-danlos-syndrome-symptoms

  Understanding the symptoms and potential complications associated with EDS is crucial for individuals living with this condition. By recognizing the signs and seeking appropriate medical care, individuals with EDS can work towards managing their symptoms and improving their overall quality of life. […] One of the most common complications experienced by individuals with EDS is joint dislocation. Overly flexible joints can lead to frequent dislocations, causing pain and instability. […] Arthritis is another complication that individuals with EDS may face. Due to the chronic stress placed on joints, early-onset arthritis can occur. This can contribute to pain, inflammation, and reduced mobility. […] The fragile skin associated with EDS can pose challenges for wound healing. The skin may be more prone to tearing and may not be strong enough to hold stitches, resulting in delayed healing and prominent scarring. […] Pain is a common symptom experienced by individuals with EDS. Chronic pain can significantly impact daily life and overall well-being. Effective pain management strategies are essential for improving quality of life.

• #89 Ehlers-Danlos Syndrome – Best Treatment Options in 2025

  https://prohealthclinic.co.uk/blog/ehlers-danlos-syndrome/

  Delayed wound healing due to the fragility of blood vessels, not enough oxygen and nutrients are transported to the body, resulting in slow and delayed healing. […] The pain experienced by individuals suffering from Ehlers-Danlos Syndrome requires analgesics to manage pain. […] Patients of Ehlers-Danlos Syndrome suffer from chronic musculoskeletal pain, which is often due to a fracture of a joint or excessive stretch of ligaments.

• #90 Ehlers Danlos Syndrome and Gastroparesis

  https://edsnutrition.com/ehlers-danlos-syndrome-and-gastroparesis/

  In my clinical experience of seeing numerous patients with EDS and symptoms of gastroparesis, it seems like there could be a connection between these conditions. However, research on the link between these conditions is still evolving. […] Gastroparesis symptoms can be managed with medications, diet, lifestyle, and in some cases, procedures. […] The most common type of medication used to address gastroparesis is prokinetics. Prokinetics stimulates gastrointestinal motility, which can help food move out of the stomach more quickly. The only approved prokinetic to treat gastroparesis is called metoclopramide. […] The gastroparesis diet may help reduce severe gastroparesis symptoms. The gastroparesis diet mainly includes easier-to-digest and higher-carbohydrate foods because these typically are digested quite quickly. The gastroparesis diet emphasizes purees and liquids because these move through the gastrointestinal tract the quickest.

• #91 Does EDS get worse as you age? – The Fibro Guy

  https://www.thefibroguy.com/blog/does-eds-get-worse-as-you-age/

  However, recent studies on celiprolol, a beta-blocker used to reduce arterial stress, have shown promise in improving survival rates and reducing the frequency of major vascular events. […] Unlike vEDS, hypermobile EDS doesn’t come with the same life-threatening vascular risks, but that doesn’t mean the aging process is easy. […] Despite the decline in hypermobility, studies show that up to 90% of adults with hEDS experience worsening musculoskeletal pain, fatigue, and proprioceptive impairments as they age. […] Many also develop secondary conditions like dysautonomia (POTS), chronic fatigue syndrome, and mast cell activation syndrome (MCAS), which can significantly affect daily life. […] For individuals with classical EDS, caused by mutations in COL5A1 or COL5A3, skin fragility and wound healing problems tend to worsen over time.

• #92 Ehlers-Danlos Syndrome: Types, Symptoms, and Treatment InsightsAccessibility ToolsIncrease TextDecrease TextGrayscaleHigh ContrastNegative ContrastLight BackgroundLinks UnderlineReadable FontReset

  https://www.specialstrong.com/ehlers-danlos-syndrome-types-symptoms-and-treatment-insights/

  Recognizing Ehlers-Danlos symptoms is pivotal for early intervention and tailored management. Whether experiencing common symptoms or navigating the complexities of vEDS, heightened awareness, and collaborative healthcare efforts contribute to improved outcomes for individuals with this diverse spectrum of connective tissue disorders. […] Many people living with EDS experience various orthopedic issues. Joint instability and hypermobility can lead to dislocations, early-onset arthritis, and an increased risk of injury. Skin elasticity may result in slow wound healing and abnormal scarring. […] Severe complications are more common in specific subtypes, such as vascular EDS, where the fragility of the blood vessels might cause severe complications like arterial or organ rupture. […] Ehlers-Danlos syndrome is a group of genetic disorders impacting an individual’s connective tissues, causing symptoms like joint instability, skin elasticity, and in some cases, severe complications.

• #93 23 Signs You Grew Up With Ehlers-danlos Syndrome [2025]

  https://www.xcode.life/carrier-status/23-signs-ehlers-danlos-syndrome/

  Ehlers-Danlos Syndrome (EDS) often goes undiagnosed or misdiagnosed because its signs like hypermobility, chronic pain, frequent injuries, and fatigue can resemble other common conditions. Recognizing key indicators like joint hyperflexibility, recurrent dislocations, and digestive problems can help achieve an accurate diagnosis. Early and accurate identification of EDS enables appropriate management strategies such as physical therapy, dietary adjustments, pain management, and lifestyle modifications to improve quality of life. Always consult with a healthcare professional familiar with EDS for comprehensive evaluation and personalized treatment. […] Though people with Ehler-Danlos syndrome are born with the condition, it may take years before it gets diagnosed. […] Chronic pain at a young age: Early-onset, persistent pain is common and can significantly impact quality of life.

• #94 EDS Info – Ehlers-Danlos Syndromes New Zealand

  https://ehlers-danlos.org.nz/eds-info/?srsltid=AfmBOorn0K470Ykrg9b5mbU0g41vxYyqpPDC6pbdJ2b6wp_kZoEuoqyu

  A body with EDS can behave unreliably, and issues can be widespread and range in severity, from barely noticeable to life-threatening. It can appear as though a person has a large number of seemingly-unrelated symptoms. […] The prognosis depends on the type of Ehlers-Danlos Syndrome and the individual patient. Life expectancy can be shortened for those with Vascular Ehlers-Danlos Syndrome due to the possibility of organ and vessel rupture. Life expectancy is usually not affected in other types. There can be a wide or narrow range of severity within a family, but each persons case of Ehlers-Danlos Syndrome will be unique. While there is no cure for the Ehlers-Danlos Syndromes, there is treatment for some symptoms, and there are preventative measures that can be very helpful.

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