Materiały źródłowe

• #1 Cushing Syndrome: Causes, Symptoms & Treatment

  https://my.clevelandclinic.org/health/diseases/5497-cushing-syndrome

  Cushing syndrome is a condition caused by too much of the hormone cortisol in the body. There are treatments for Cushing syndrome. Treatment may last for some time. […] Cushing syndrome affects several body systems, causing a multitude of symptoms. Cushing syndrome has some unique symptoms as well as some that could point towards a variety of other syndromes. Not everyone has the same symptoms. Possible characteristics include: Rapid weight gain in the face (sometimes called moon face), abdomen, back of the neck (sometimes called buffalo hump) and chest. A red, round face. Wounds that heal poorly. High blood pressure (hypertension). Excessive hair growth on the face, neck, chest, abdomen, breasts and thighs, or balding. Diabetes. […] How long Cushing syndrome lasts depends on how you respond to treatment. Many people with hypercortisolism recover after several weeks of treatment. […] Cushing syndrome can get worse without proper treatment. Be sure to stay in contact with your healthcare provider and report any new or worsening symptoms or any other concerns you may have.

• #2 Cushing syndrome: MedlinePlus Medical EncyclopediaLock

  https://medlineplus.gov/ency/article/000410.htm

  Cushing syndrome is a disorder that occurs when your body has a high level of the hormone cortisol. […] Not everyone with Cushing syndrome has the same symptoms. Some people have many symptoms while others have hardly any symptoms. Symptoms usually get worse over time. […] Most people with Cushing syndrome have: Round, red, full face (moon face), Slow growth rate (in children), Weight gain with fat accumulation on the trunk, but fat loss from the arms, legs, and buttocks (central obesity). […] Skin changes can include: Skin infections, Purple stretch marks (1/2 inch or 1 centimeter or more wide) called striae on the skin of the abdomen, upper arms, thighs, and breasts, Thin skin with easy bruising (especially on the arms and hands). […] Muscle and bone changes include: Backache, which occurs with routine activities, Bone pain or tenderness, Collection of fat between the shoulders and above collar bones, Rib and spine fractures caused by thinning of the bones, Weak muscles, especially of the hips and shoulders.

• #3 Cushing syndrome – Symptoms and causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/cushing-syndrome/symptoms-causes/syc-20351310

  Without treatment, Cushing syndrome can cause facial roundness, weight gain around the middle body and upper back, thinning of the arms and legs, easy bruising, and stretch marks. […] Too much cortisol can cause some of the main symptoms of Cushing syndrome a fatty hump between the shoulders, a rounded face, and pink or purple stretch marks on the skin. Cushing syndrome also can cause high blood pressure or bone loss. Sometimes, it can cause type 2 diabetes. […] Symptoms of Cushing syndrome can vary depending on the level of extra cortisol. […] Common symptoms of Cushing syndrome include weight gain in the trunk, with thin arms and legs, weight gain in the face, a fatty lump between the shoulders, pink or purple stretch marks on the stomach, hips, thighs, breasts and underarms, thin, frail skin that bruises easily, slow wound healing, and acne.

• #4 Cushing syndrome Information | Mount Sinai – New York

  https://www.mountsinai.org/health-library/diseases-conditions/cushing-syndrome

  Cushing syndrome is a disorder that occurs when your body has a high level of the hormone cortisol. […] Not everyone with Cushing syndrome has the same symptoms. Some people have many symptoms while others have hardly any symptoms. Symptoms usually get worse over time. […] Most people with Cushing syndrome have: Round, red, full face (moon face), Slow growth rate (in children), Weight gain with fat accumulation on the trunk, but fat loss from the arms, legs, and buttocks (central obesity). […] Skin changes can include: Skin infections, Purple stretch marks (1/2 inch or 1 centimeter or more wide) called striae on the skin of the abdomen, upper arms, thighs, and breasts, Thin skin with easy bruising (especially on the arms and hands). […] Muscle and bone changes include: Backache, which occurs with routine activities, Bone pain or tenderness, Collection of fat between the shoulders and above collar bones, Rib and spine fractures caused by thinning of the bones, Weak muscles, especially of the hips and shoulders.

• #5 Cushing’s Syndrome – NIDDK

  https://www.niddk.nih.gov/health-information/endocrine-diseases/cushings-syndrome

  Signs and symptoms of Cushing’s syndrome vary. People who have very high levels of cortisol for a long time are likely to have clear signs of the disorder, including weight gain, thin arms and legs, a round face, increased fat around the base of the neck, a fatty hump between the shoulders, easy bruising, wide purple stretch marks, mainly on the abdomen, breasts, hips, and under the arms, and weak muscles. […] Children with Cushing’s syndrome tend to have obesity and grow more slowly than other children. Women may have excess hair on their face, neck, chest, abdomen, and thighs. Menstrual periods may become irregular or stop. Men may have decreased fertility with lowered interest in sex and may have erectile dysfunction. […] Not everyone with Cushing’s syndrome has these symptoms, which can make it hard to detect.

• #6 Symptoms of Cushing’s Disease – Pituitary Foundation

  https://www.pituitary.org.uk/information/cushings-symptoms/

  Cushings disease is a condition caused by having too much of a hormone called cortisol in your body. There are a wide range of varied symptoms for Cushings Disease, and usually several are present at once. […] The symptoms of Cushings disease are varied and usually develop gradually, so a diagnosis may not be clear for some time. Usually several symptoms are present at once. […] Symptoms include: […] Excessive and sudden (or at times more gradual) onset of weight gain around your trunk; your arms and legs may remain unchanged and can become quite thin compared to your body. […] Fatty hump at top of spine/back (also known as an interscapular hump). […] Weak muscles, especially in your legs. […] Your face tends to be rounder and redder than normal (a classic symptom of Cushings known as moon face) and you may have developed acne.

• #7 Cushing Syndrome: Signs, Causes, and Treatment

  https://www.healthline.com/health/cushings-syndrome

  Cushing syndrome occurs due to abnormally high levels of cortisol, which is commonly related to steroid use. Symptoms include weight gain, thinning skin, fluid retention, and stretch marks, among others. […] Cushing syndrome may cause a wide range of symptoms, including: unintentional weight gain, fatty deposits, especially in the midsection, the face (causing a round, moon-shaped face), and between the shoulders and the upper back (sometimes causing a visual hump), purple stretch marks on the breasts, arms, abdomen, and thighs, muscle weakness, edema (fluid retention), thinning skin that bruises easily, hyperhidrosis (excessive sweating), skin injuries that are slow to heal, back pain, bone pain, acne, fatigue, increased number of infections, anxiety, irritability, depression, mood changes, hypertension (high blood pressure), hyperglycemia (high blood sugar), increased thirst, increased urination.

• #8 Cushing’s Disease Symptoms & Treatment – Pituitary & Skull Base Tumor | UCLA Health

  https://www.uclahealth.org/medical-services/neurosurgery/pituitary-skull-base-tumor/conditions/pituitary-adenomas/cushings-disease

  Cushing’s disease is a serious condition of an excess of the steroid hormone cortisol in the blood level caused by a pituitary tumor secreting adrenocorticotropic hormone (ACTH). […] The symptoms related to Cushing’s disease and Cushing’s syndrome are the same, since both are related to an excess of cortisol. Cushings disease symptoms may include: […] Changes in physical characteristics of the body […] Fullness and rounding of the face (so-called „moon facies”) […] Added fat on back of neck (so-called „buffalo hump”) […] Easy bruising of the skin […] Purplish stretch marks on the abdomen (abdominal striae) […] Excessive weight gain, most marked in the abdominal region, while the legs and arms remain thin […] Generalized weakness and fatigue; wasting of muscles, most noticeably in the upper thighs (You may have difficulty getting up from a chair)

• #9 Cushing’s Syndrome

  https://resources.healthgrades.com/right-care/endocrinology-and-metabolism/cushings-syndrome

  Cushing’s syndrome is caused by abnormally high levels of the hormone cortisol. […] High levels of cortisol can impair the function of hormones in the body, which results in a variety of symptoms including a moon-faced appearance, upper body obesity, and fatigue. […] Seek prompt medical care if you have symptoms of Cushing’s syndrome, such as weight gain in the upper body, fatigue, and the development of unusual roundness of the face. […] At the onset of Cushing’s syndrome, symptoms can be mild and develop slowly. They can also vary among individuals. Symptoms of Cushing’s syndrome can include: Acne, Back pain, Easy bruising, Emotional changes, Fat pad between the shoulder blades, Fatigue, High blood pressure, Increase in body hair, Memory problems, Muscle weakness, Round, moon-shaped face, Thinning of the skin, Upper body obesity.

• #10 Patient education: Cushing syndrome (Beyond the Basics) – UpToDate

  https://www.uptodate.com/contents/cushings-syndrome-beyond-the-basics

  Skin changes — In Cushing syndrome, the skin tends to become thin, fragile, and more susceptible to bruises and infections. Wounds heal poorly. Wide, reddish-purple stretch marks, called striae, can develop in areas of weight gain. […] Irregular menstrual periods — Females with Cushing syndrome may have a variety of menstrual problems, most typically infrequent or absent menstrual periods. They often have difficulty becoming pregnant. […] Excess body hair and acne — Females with Cushing syndrome may have signs of male hormone (androgen) excess, such as hirsutism (growth of coarse body or facial hair in a male pattern), oily skin, and acne. Males with Cushing syndrome do not develop excess body hair, but they may have acne. […] Muscle loss and weakness — Prolonged Cushing syndrome causes the muscles of the shoulder and thighs/hips to become weaker. Some individuals notice that it becomes more difficult to get out of a chair or climb stairs because of the upper leg weakness.

• #11 Patient education: Cushing syndrome (Beyond the Basics) – UpToDate

  https://www.uptodate.com/contents/cushings-syndrome-beyond-the-basics

  Skin changes — In Cushing syndrome, the skin tends to become thin, fragile, and more susceptible to bruises and infections. Wounds heal poorly. Wide, reddish-purple stretch marks, called striae, can develop in areas of weight gain. […] Irregular menstrual periods — Females with Cushing syndrome may have a variety of menstrual problems, most typically infrequent or absent menstrual periods. They often have difficulty becoming pregnant. […] Excess body hair and acne — Females with Cushing syndrome may have signs of male hormone (androgen) excess, such as hirsutism (growth of coarse body or facial hair in a male pattern), oily skin, and acne. Males with Cushing syndrome do not develop excess body hair, but they may have acne. […] Muscle loss and weakness — Prolonged Cushing syndrome causes the muscles of the shoulder and thighs/hips to become weaker. Some individuals notice that it becomes more difficult to get out of a chair or climb stairs because of the upper leg weakness.

• #12 Cushing syndrome – Symptoms and causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/cushing-syndrome/symptoms-causes/syc-20351310

  Without treatment, Cushing syndrome can cause facial roundness, weight gain around the middle body and upper back, thinning of the arms and legs, easy bruising, and stretch marks. […] Too much cortisol can cause some of the main symptoms of Cushing syndrome a fatty hump between the shoulders, a rounded face, and pink or purple stretch marks on the skin. Cushing syndrome also can cause high blood pressure or bone loss. Sometimes, it can cause type 2 diabetes. […] Symptoms of Cushing syndrome can vary depending on the level of extra cortisol. […] Common symptoms of Cushing syndrome include weight gain in the trunk, with thin arms and legs, weight gain in the face, a fatty lump between the shoulders, pink or purple stretch marks on the stomach, hips, thighs, breasts and underarms, thin, frail skin that bruises easily, slow wound healing, and acne.

• #13 Cushing’s Syndrome and Cushing Disease | Endocrine Society

  https://www.endocrine.org/patient-engagement/endocrine-library/cushings-syndrome-and-cushing-disease

  Cushing syndrome (also sometimes called Cushing’s syndrome) is a disorder with physical and mental changes that result from having too much cortisol in the blood for a long period of time. […] Symptoms of Cushings Syndrome include: Weight gain, especially in the upper body, Rounded face and extra fat on the upper back and above the collarbones, High blood sugar (diabetes), High blood pressure (hypertension), Thin bones (osteoporosis), Muscle loss and weakness, Thin, fragile skin that bruises easily, Purple-red stretch marks (usually over the abdomen and under the arms), Depression and difficulties thinking clearly, Too much facial hair in women. […] Cushing disease has many symptoms including changes in appearance, mood and thinking, and more. […] Changes in appearance: Wide, purple stretch marks on the skin (chest, armpits, abdomen, flanks), Rapid and unexplained weight gain with a rounder face and abdomen, Increased fat in the neck and above the collarbone and upper back, Skin changes (bruising without injury, acne, hair growth) and red cheeks.

• #14 Cushing syndrome

  https://dermnetnz.org/topics/cushing-syndrome

  Cushing syndrome is a hormonal disorder caused by prolonged exposure to inappropriately high levels of plasma glucocorticoid (also referred to as cortisol) hormones. […] The most distinctive features of Cushing syndrome are the deposits of fat over the clavicles and back of the neck (buffalo hump), the rounded puffy face (moon face, tomato face) with the contrasting slender wasted limbs. Bones are weakened, and activities such as bending, lifting or rising from a chair may lead to backaches, rib and spinal fractures. Many people suffer severe fatigue, weak muscles, high blood pressure, high blood sugar, irritability, anxiety and depression. […] Signs and symptoms appearing in the skin include: Easy bruising (purpura) and purple striae of the skin over the abdomen, buttocks and thighs, Telangiectatic cheeks (broken capillaries), Fragile skin and poor wound healing, Acne and hirsutism (excessive hair growth in women on their faces, necks, chests, abdomens and thighs), Women may also show clitoral hypertrophy and male-pattern baldness.

• #15 Cushing’s Syndrome: Symptoms and Causes | Tampa General

  https://www.tgh.org/institutes-and-services/conditions/cushings-syndrome

  Cushings syndrome (hypercortisolism) occurs when the bodys adrenal glands produce too much cortisol. The most well-known symptoms of Cushings syndrome are tied to rapid weight gain in much of the upper body, excluding the arms. These include a rounded face, a buffalo hump in the upper back and weight gain in the abdomen and chest areas. Other symptoms that point to Cushings syndrome include purple stretch marks on and around the abdomen. Other possible symptoms include: Easily bruised skin […] Slowed healing of wounds […] High blood pressure […] Fatigue and weakness […] Diabetes […] Blurry vision. Men may experience erectile dysfunction and decreased sex drive. Women may experience irregular menstrual periods and excessive body hair growth. If left untreated, Cushings syndrome can cause serious health problems and potentially be fatal.

• #16 Cushing Syndrome: Signs, Causes, and Treatment

  https://www.healthline.com/health/cushings-syndrome

  Cushing syndrome occurs due to abnormally high levels of cortisol, which is commonly related to steroid use. Symptoms include weight gain, thinning skin, fluid retention, and stretch marks, among others. […] Cushing syndrome may cause a wide range of symptoms, including: unintentional weight gain, fatty deposits, especially in the midsection, the face (causing a round, moon-shaped face), and between the shoulders and the upper back (sometimes causing a visual hump), purple stretch marks on the breasts, arms, abdomen, and thighs, muscle weakness, edema (fluid retention), thinning skin that bruises easily, hyperhidrosis (excessive sweating), skin injuries that are slow to heal, back pain, bone pain, acne, fatigue, increased number of infections, anxiety, irritability, depression, mood changes, hypertension (high blood pressure), hyperglycemia (high blood sugar), increased thirst, increased urination.

• #17 Cushing syndrome Information | Mount Sinai – New York

  https://www.mountsinai.org/health-library/diseases-conditions/cushing-syndrome

  Body-wide (systemic) changes include: Type 2 diabetes mellitus, High blood pressure (hypertension), Increased cholesterol and triglycerides (hyperlipidemia). […] Women with Cushing syndrome may have: Excess hair growth on the face, neck, chest, abdomen, and thighs, Periods that become irregular or stop. […] Men may have: Decreased or no desire for sex (low libido), Erection problems. […] Other symptoms that may occur with this disease: Mental changes, such as depression, anxiety, or changes in behavior, Fatigue, Headache, Increased thirst and urination. […] Symptoms usually get worse over time.

• #18 Cushing’s syndrome – Wikipedia

  https://en.wikipedia.org/wiki/Cushing%27s_syndrome

  Symptoms include rapid weight gain, particularly of the trunk and face with sparing of the limbs (central obesity). Common signs include the growth of fat pads along the collarbone, on the back of the neck („buffalo hump” or lipodystrophy), and on the face („moon face”). Other symptoms include excess sweating, dilation of capillaries, thinning of the skin (which causes easy bruising and dryness, particularly the hands) and mucous membranes, purple or red striae (the weight gain in Cushing’s syndrome stretches the skin, which is thin and weakened, causing it to hemorrhage) on the trunk, buttocks, arms, legs, or breasts, proximal muscle weakness (hips, shoulders), and hirsutism (facial male-pattern hair growth), baldness and/or extremely dry and brittle hair. […] Many of the features of Cushing’s are those seen in metabolic syndrome, including insulin resistance, hypertension, obesity, and elevated blood levels of triglycerides.

• #19 Patient education: Cushing syndrome (Beyond the Basics) – UpToDate

  https://www.uptodate.com/contents/cushings-syndrome-beyond-the-basics

  Skin changes — In Cushing syndrome, the skin tends to become thin, fragile, and more susceptible to bruises and infections. Wounds heal poorly. Wide, reddish-purple stretch marks, called striae, can develop in areas of weight gain. […] Irregular menstrual periods — Females with Cushing syndrome may have a variety of menstrual problems, most typically infrequent or absent menstrual periods. They often have difficulty becoming pregnant. […] Excess body hair and acne — Females with Cushing syndrome may have signs of male hormone (androgen) excess, such as hirsutism (growth of coarse body or facial hair in a male pattern), oily skin, and acne. Males with Cushing syndrome do not develop excess body hair, but they may have acne. […] Muscle loss and weakness — Prolonged Cushing syndrome causes the muscles of the shoulder and thighs/hips to become weaker. Some individuals notice that it becomes more difficult to get out of a chair or climb stairs because of the upper leg weakness.

• #20 Endogenous Cushing Syndrome Clinical Presentation: History, Physical Examination

  https://emedicine.medscape.com/article/2233083-clinical

  Patients with Cushing syndrome may complain of weight gain, especially in the face, supraclavicular region, upper back, and torso. Frequently, patients notice changes in their skin, including purple stretch marks, easy bruising, and other signs of skin thinning. Because of progressive proximal muscle weakness, patients may have difficulty climbing stairs, getting out of a low chair, and raising their arms. […] Menstrual irregularities, amenorrhea, infertility, and decreased libido may occur in women related to inhibition of pulsatile secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which likely is due to interruption of luteinizing hormone-releasing hormone (LHRH) pulse generation. In men, inhibition of LHRH and FSH/LH function may lead to decreased libido and impotence.

• #21 Cushing syndrome – Symptoms and causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/cushing-syndrome/symptoms-causes/syc-20351310

  Other possible symptoms of Cushing syndrome include extreme tiredness, muscle weakness, depression, anxiety and irritability, emotions that are hard to control, trouble concentrating or remembering, sleeplessness, high blood pressure, headache, infections, skin darkening, bone loss, which can lead to broken bones, and stunted growth in children. […] Without treatment, Cushing syndrome can cause complications, including bone loss, also called osteoporosis, which can lead to broken bones, high blood pressure, type 2 diabetes, serious or multiple infections, and loss of muscle mass and strength.

• #22 Patient education: Cushing syndrome (Beyond the Basics) – UpToDate

  https://www.uptodate.com/contents/cushings-syndrome-beyond-the-basics

  Bone loss — Cushing syndrome can lead to thinning of the bones (osteoporosis), which can eventually result in fractures of the ribs, long bones, and spinal vertebrae. […] Prediabetes — Excess cortisol can cause an elevation of blood glucose levels (often called „prediabetes”). People with Cushing syndrome may develop glucose intolerance, a condition that can progress to diabetes, or diabetes itself. […] High blood pressure and cardiovascular disease — Excess cortisol raises blood pressure and puts stress on the heart and vascular system. […] Psychologic symptoms and „brain fog” — Over one-half of people with Cushing syndrome have psychologic symptoms that range from loss of emotional control, irritability, and depression to panic attacks and paranoia. Insomnia is also common. […] Many people with Cushing syndrome have difficulties with memory, processing written information, and mathematical calculations.

• #23 Cushing’s Syndrome | Conditions | UCSF Health

  https://www.ucsfhealth.org/conditions/cushings-syndrome

  Symptoms of Cushing’s syndrome may include: […] Change in body form, particularly weight gain in the face that is referred to as moon facies as well as fat deposition above the collar bone, called supraclavicular fat, and at the back of neck, called a buffalo hump. […] Skin changes with easy bruising, purplish stretch marks, called stria, and red cheeks […] Excess hair growth on face, neck, chest, abdomen and thighs […] Overall weakness and fatigue […] Loss of muscle bulk […] Menstrual disorders in women […] Decreased fertility and/or sex drive […] Hypertension […] Diabetes mellitus […] Depression with wide mood swings.

• #24 Cushing syndrome Information | Mount Sinai – New York

  https://www.mountsinai.org/health-library/diseases-conditions/cushing-syndrome

  Cushing syndrome is a disorder that occurs when your body has a high level of the hormone cortisol. […] Not everyone with Cushing syndrome has the same symptoms. Some people have many symptoms while others have hardly any symptoms. Symptoms usually get worse over time. […] Most people with Cushing syndrome have: Round, red, full face (moon face), Slow growth rate (in children), Weight gain with fat accumulation on the trunk, but fat loss from the arms, legs, and buttocks (central obesity). […] Skin changes can include: Skin infections, Purple stretch marks (1/2 inch or 1 centimeter or more wide) called striae on the skin of the abdomen, upper arms, thighs, and breasts, Thin skin with easy bruising (especially on the arms and hands). […] Muscle and bone changes include: Backache, which occurs with routine activities, Bone pain or tenderness, Collection of fat between the shoulders and above collar bones, Rib and spine fractures caused by thinning of the bones, Weak muscles, especially of the hips and shoulders.

• #25 Cushing syndrome – Symptoms, diagnosis and treatment | BMJ Best Practice

  https://bestpractice.bmj.com/topics/en-gb/205

  Cushing syndrome is the clinical manifestation of pathological hypercortisolism from any cause. […] Features more specific to Cushing syndrome include proximal muscle weakness, supraclavicular fat pads, facial plethora, violaceous striae, easy bruising, and premature osteoporosis. […] Patients often display weight gain with central obesity, facial rounding and plethora, proximal muscle weakness, and thinning of the skin. They also develop metabolic complications including diabetes mellitus, dyslipidaemia, metabolic bone disease, and hypertension. […] Other diagnostic factors include hypertension, glucose intolerance or diabetes mellitus, premature osteoporosis or unexplained fractures, weight gain and central obesity, easy bruisability, and weakness.

• #26 Cushing’s Disease Symptoms & Treatment – Pituitary & Skull Base Tumor | UCLA Health

  https://www.uclahealth.org/medical-services/neurosurgery/pituitary-skull-base-tumor/conditions/pituitary-adenomas/cushings-disease

  High blood pressure that is often difficult to treat […] Diabetes mellitus, often severe […] Mood and behavior disorders; some patients have psychiatric disorders that require hospitalization […] Although uncommon, some patients with Cushing’s disease have large pituitary tumors (macroadenomas). […] In addition to the severe hormonal effects related to increase blood cortisol levels, the large tumor can compress adjacent structures leading to: […] Vision loss […] When large pituitary adenomas (macroadenomas) grow upward into the brain cavity, the tumor can elevate and compress the optic chiasm, the part of the brain where the optic nerves partially cross. […] A loss of the outer peripheral vision occurs, called a bitemporal hemianopsia […] Increased compression of the normal gland can cause hormone insufficiency, called hypopituitarism. […] The early stages of Cushing’s disease may be difficult to recognize, especially because the body changes develop slowly. […] The diagnosis may be difficult to make because sometimes the hormone elevations come and go: so called „cyclic” or „periodic” Cushing’s disease.

• #27 Patient education: Cushing syndrome (Beyond the Basics) – UpToDate

  https://www.uptodate.com/contents/cushings-syndrome-beyond-the-basics

  Bone loss — Cushing syndrome can lead to thinning of the bones (osteoporosis), which can eventually result in fractures of the ribs, long bones, and spinal vertebrae. […] Prediabetes — Excess cortisol can cause an elevation of blood glucose levels (often called „prediabetes”). People with Cushing syndrome may develop glucose intolerance, a condition that can progress to diabetes, or diabetes itself. […] High blood pressure and cardiovascular disease — Excess cortisol raises blood pressure and puts stress on the heart and vascular system. […] Psychologic symptoms and „brain fog” — Over one-half of people with Cushing syndrome have psychologic symptoms that range from loss of emotional control, irritability, and depression to panic attacks and paranoia. Insomnia is also common. […] Many people with Cushing syndrome have difficulties with memory, processing written information, and mathematical calculations.

• #28 Signs and Symptoms of Cushing Syndrome – Cortisol Matters

  https://www.cortisolmatters.com/patient/cushing-syndrome-symptoms

  Symptoms of Cushing syndrome (hypercortisolism) vary from person to person. Everyone may experience symptoms of Cushing syndrome differently and at varying levels of severity. Some common signs and symptoms include: […] About 70% to 75% of people with Cushing syndrome have problems controlling their blood sugar. […] More than 80% of people with Cushing syndrome have weight gain and changes in appearance. […] At least 70% of people with Cushing syndrome have depression or cognitive changes (such as changes in mood, concentration, or memory). […] 66% to 79% of people with Cushing syndrome have anxiety. […] People with Cushing syndrome are at increased risk for heart disease and stroke. […] As Cushing syndrome gets worse, the body may become increasingly susceptible to new or worsening infections.

• #29 Cushing’s Disease Symptoms & Treatment – Pituitary & Skull Base Tumor | UCLA Health

  https://www.uclahealth.org/medical-services/neurosurgery/pituitary-skull-base-tumor/conditions/pituitary-adenomas/cushings-disease

  High blood pressure that is often difficult to treat […] Diabetes mellitus, often severe […] Mood and behavior disorders; some patients have psychiatric disorders that require hospitalization […] Although uncommon, some patients with Cushing’s disease have large pituitary tumors (macroadenomas). […] In addition to the severe hormonal effects related to increase blood cortisol levels, the large tumor can compress adjacent structures leading to: […] Vision loss […] When large pituitary adenomas (macroadenomas) grow upward into the brain cavity, the tumor can elevate and compress the optic chiasm, the part of the brain where the optic nerves partially cross. […] A loss of the outer peripheral vision occurs, called a bitemporal hemianopsia […] Increased compression of the normal gland can cause hormone insufficiency, called hypopituitarism. […] The early stages of Cushing’s disease may be difficult to recognize, especially because the body changes develop slowly. […] The diagnosis may be difficult to make because sometimes the hormone elevations come and go: so called „cyclic” or „periodic” Cushing’s disease.

• #30 Cushing syndrome Information | Mount Sinai – New York

  https://www.mountsinai.org/health-library/diseases-conditions/cushing-syndrome

  Body-wide (systemic) changes include: Type 2 diabetes mellitus, High blood pressure (hypertension), Increased cholesterol and triglycerides (hyperlipidemia). […] Women with Cushing syndrome may have: Excess hair growth on the face, neck, chest, abdomen, and thighs, Periods that become irregular or stop. […] Men may have: Decreased or no desire for sex (low libido), Erection problems. […] Other symptoms that may occur with this disease: Mental changes, such as depression, anxiety, or changes in behavior, Fatigue, Headache, Increased thirst and urination. […] Symptoms usually get worse over time.

• #31 Cushing syndrome Information | Mount Sinai – New York

  https://www.mountsinai.org/health-library/diseases-conditions/cushing-syndrome

  Body-wide (systemic) changes include: Type 2 diabetes mellitus, High blood pressure (hypertension), Increased cholesterol and triglycerides (hyperlipidemia). […] Women with Cushing syndrome may have: Excess hair growth on the face, neck, chest, abdomen, and thighs, Periods that become irregular or stop. […] Men may have: Decreased or no desire for sex (low libido), Erection problems. […] Other symptoms that may occur with this disease: Mental changes, such as depression, anxiety, or changes in behavior, Fatigue, Headache, Increased thirst and urination. […] Symptoms usually get worse over time.

• #32 Cushing Syndrome: Signs, Causes, and Treatment

  https://www.healthline.com/health/cushings-syndrome

  Children can have Cushing syndrome, although they develop it less frequently than adults. According to a 2018 review, about 1 in 10 new cases of Cushing syndrome each year occur in children. In addition to the symptoms above, children with Cushing syndrome may also have obesity and a slower rate of growth. […] Cushing syndrome is more prevalent in females than in males. According to the National Institutes of Health, three times as many females develop Cushing syndrome compared with males. […] Some common symptoms of high cortisol may include stress, fatigue, headaches, unexplained weight gain, muscle weakness, bone pain, skin injuries, and easy bruising, among others.

• #33 Cushing syndrome Information | Mount Sinai – New York

  https://www.mountsinai.org/health-library/diseases-conditions/cushing-syndrome

  Body-wide (systemic) changes include: Type 2 diabetes mellitus, High blood pressure (hypertension), Increased cholesterol and triglycerides (hyperlipidemia). […] Women with Cushing syndrome may have: Excess hair growth on the face, neck, chest, abdomen, and thighs, Periods that become irregular or stop. […] Men may have: Decreased or no desire for sex (low libido), Erection problems. […] Other symptoms that may occur with this disease: Mental changes, such as depression, anxiety, or changes in behavior, Fatigue, Headache, Increased thirst and urination. […] Symptoms usually get worse over time.

• #34 Cushing’s Syndrome – NIDDK

  https://www.niddk.nih.gov/health-information/endocrine-diseases/cushings-syndrome

  Signs and symptoms of Cushing’s syndrome vary. People who have very high levels of cortisol for a long time are likely to have clear signs of the disorder, including weight gain, thin arms and legs, a round face, increased fat around the base of the neck, a fatty hump between the shoulders, easy bruising, wide purple stretch marks, mainly on the abdomen, breasts, hips, and under the arms, and weak muscles. […] Children with Cushing’s syndrome tend to have obesity and grow more slowly than other children. Women may have excess hair on their face, neck, chest, abdomen, and thighs. Menstrual periods may become irregular or stop. Men may have decreased fertility with lowered interest in sex and may have erectile dysfunction. […] Not everyone with Cushing’s syndrome has these symptoms, which can make it hard to detect.

• #35 Signs and Symptoms of Cushing Syndrome – Cortisol Matters

  https://www.cortisolmatters.com/patient/cushing-syndrome-symptoms

  24% to 90% of people with Cushing syndrome have a reduced sex drive. […] 50% to 75% of men with Cushing syndrome have low testosterone levels (hypogonadism). […] 43% to 80% of women with Cushing syndrome have irregular menstrual periods. […] The percentage of people with Cushing syndrome who have bone loss and spinal fractures may be as high as 10.8%. […] About 73% of people with Cushing syndrome have changes to their skin. […] As Cushing syndrome worsens, muscle mass shrinks. […] The condition tends to worsen over time. […] The longer a person is exposed to excess cortisol, the worse the symptoms may become. […] Symptoms of Cushing syndrome may differ from person to person. […] No single sign or symptom points to a diagnosis. […] Some symptoms of Cushing syndrome are more obvious than others.

• #36 Cushing syndrome Information | Mount Sinai – New York

  https://www.mountsinai.org/health-library/diseases-conditions/cushing-syndrome

  Body-wide (systemic) changes include: Type 2 diabetes mellitus, High blood pressure (hypertension), Increased cholesterol and triglycerides (hyperlipidemia). […] Women with Cushing syndrome may have: Excess hair growth on the face, neck, chest, abdomen, and thighs, Periods that become irregular or stop. […] Men may have: Decreased or no desire for sex (low libido), Erection problems. […] Other symptoms that may occur with this disease: Mental changes, such as depression, anxiety, or changes in behavior, Fatigue, Headache, Increased thirst and urination. […] Symptoms usually get worse over time.

• #37 Cushing’s Syndrome – NIDDK

  https://www.niddk.nih.gov/health-information/endocrine-diseases/cushings-syndrome

  Signs and symptoms of Cushing’s syndrome vary. People who have very high levels of cortisol for a long time are likely to have clear signs of the disorder, including weight gain, thin arms and legs, a round face, increased fat around the base of the neck, a fatty hump between the shoulders, easy bruising, wide purple stretch marks, mainly on the abdomen, breasts, hips, and under the arms, and weak muscles. […] Children with Cushing’s syndrome tend to have obesity and grow more slowly than other children. Women may have excess hair on their face, neck, chest, abdomen, and thighs. Menstrual periods may become irregular or stop. Men may have decreased fertility with lowered interest in sex and may have erectile dysfunction. […] Not everyone with Cushing’s syndrome has these symptoms, which can make it hard to detect.

• #38 Signs and Symptoms of Cushing Syndrome – Cortisol Matters

  https://www.cortisolmatters.com/patient/cushing-syndrome-symptoms

  24% to 90% of people with Cushing syndrome have a reduced sex drive. […] 50% to 75% of men with Cushing syndrome have low testosterone levels (hypogonadism). […] 43% to 80% of women with Cushing syndrome have irregular menstrual periods. […] The percentage of people with Cushing syndrome who have bone loss and spinal fractures may be as high as 10.8%. […] About 73% of people with Cushing syndrome have changes to their skin. […] As Cushing syndrome worsens, muscle mass shrinks. […] The condition tends to worsen over time. […] The longer a person is exposed to excess cortisol, the worse the symptoms may become. […] Symptoms of Cushing syndrome may differ from person to person. […] No single sign or symptom points to a diagnosis. […] Some symptoms of Cushing syndrome are more obvious than others.

• #39 Signs and Symptoms of Cushing Syndrome – Cortisol Matters

  https://www.cortisolmatters.com/patient/cushing-syndrome-symptoms

  24% to 90% of people with Cushing syndrome have a reduced sex drive. […] 50% to 75% of men with Cushing syndrome have low testosterone levels (hypogonadism). […] 43% to 80% of women with Cushing syndrome have irregular menstrual periods. […] The percentage of people with Cushing syndrome who have bone loss and spinal fractures may be as high as 10.8%. […] About 73% of people with Cushing syndrome have changes to their skin. […] As Cushing syndrome worsens, muscle mass shrinks. […] The condition tends to worsen over time. […] The longer a person is exposed to excess cortisol, the worse the symptoms may become. […] Symptoms of Cushing syndrome may differ from person to person. […] No single sign or symptom points to a diagnosis. […] Some symptoms of Cushing syndrome are more obvious than others.

• #40 Patient education: Cushing syndrome (Beyond the Basics) – UpToDate

  https://www.uptodate.com/contents/cushings-syndrome-beyond-the-basics

  Bone loss — Cushing syndrome can lead to thinning of the bones (osteoporosis), which can eventually result in fractures of the ribs, long bones, and spinal vertebrae. […] Prediabetes — Excess cortisol can cause an elevation of blood glucose levels (often called „prediabetes”). People with Cushing syndrome may develop glucose intolerance, a condition that can progress to diabetes, or diabetes itself. […] High blood pressure and cardiovascular disease — Excess cortisol raises blood pressure and puts stress on the heart and vascular system. […] Psychologic symptoms and „brain fog” — Over one-half of people with Cushing syndrome have psychologic symptoms that range from loss of emotional control, irritability, and depression to panic attacks and paranoia. Insomnia is also common. […] Many people with Cushing syndrome have difficulties with memory, processing written information, and mathematical calculations.

• #41 Signs and Symptoms of Cushing Syndrome – Cortisol Matters

  https://www.cortisolmatters.com/patient/cushing-syndrome-symptoms

  Symptoms of Cushing syndrome (hypercortisolism) vary from person to person. Everyone may experience symptoms of Cushing syndrome differently and at varying levels of severity. Some common signs and symptoms include: […] About 70% to 75% of people with Cushing syndrome have problems controlling their blood sugar. […] More than 80% of people with Cushing syndrome have weight gain and changes in appearance. […] At least 70% of people with Cushing syndrome have depression or cognitive changes (such as changes in mood, concentration, or memory). […] 66% to 79% of people with Cushing syndrome have anxiety. […] People with Cushing syndrome are at increased risk for heart disease and stroke. […] As Cushing syndrome gets worse, the body may become increasingly susceptible to new or worsening infections.

• #42 Signs and Symptoms of Cushing Syndrome – Cortisol Matters

  https://www.cortisolmatters.com/patient/cushing-syndrome-symptoms

  Symptoms of Cushing syndrome (hypercortisolism) vary from person to person. Everyone may experience symptoms of Cushing syndrome differently and at varying levels of severity. Some common signs and symptoms include: […] About 70% to 75% of people with Cushing syndrome have problems controlling their blood sugar. […] More than 80% of people with Cushing syndrome have weight gain and changes in appearance. […] At least 70% of people with Cushing syndrome have depression or cognitive changes (such as changes in mood, concentration, or memory). […] 66% to 79% of people with Cushing syndrome have anxiety. […] People with Cushing syndrome are at increased risk for heart disease and stroke. […] As Cushing syndrome gets worse, the body may become increasingly susceptible to new or worsening infections.

• #43 AACE Patient Guide to Rare Endocrine Diseases: Cushing’s Syndrome | American Association of Clinical Endocrinology

  https://www.aace.com/disease-and-conditions/cushings-syndrome/aace-patient-guide-rare-endocrine-diseases-cushings-syndrome

  Cushing’s syndrome is a rare condition that occurs when your body produces too much cortisol for an extended period. […] An increase in cortisol in your body can lead to multiple complications, such as: Weight gain, especially in the lower abdomen, Bone loss or osteoporosis, High blood pressure, High blood sugars or diabetes, Infections, Loss of muscle mass, Muscle weakness. […] Signs and symptoms of Cushing’s syndrome include: Bruising easily, Unexplained weight gain, An increase of fat around your face or the back of your neck, Stretch marks on your midsection, Weak muscles, Thin arms and legs, Fatigue, Confusion, Depression, Anxiety, Difficulty with focus and concentration, Difficult-to-control emotions, such as anger, Irregular period, Loss of libido, Feeling hot and sweaty often, Insomnia, waking in the middle of the night unable to get back to sleep. […] Symptoms can get worse over time or even be life-threatening if left untreated. It’s important to complete your treatment plan with your health care professional. A majority of patients achieve the goal of long-term remission, but what it takes to get there is different for each of them.

• #44 Cushing’s Disease

  https://cushingsdisease.com/cushings-disease/

  Cushing’s disease has many different symptoms. […] Rapid weight gain in the stomach area and the face is usually the first sign of Cushing’s disease. […] Cushing’s disease symptoms can differ from person to person. […] A person with Cushing’s disease might have one or the following symptoms: Depression, anxiety, problems with memory and attention a general mind „fog”. […] Cushing’s disease can make it hard to remember things. […] When cortisol levels are too high over a period of time, things like blood pressure and weight start to become unregulated. […] It is this high level of cortisol in your blood that causes the symptoms of Cushing’s disease. […] The symptoms in this case are caused by high levels of cortisol due to a pituitary tumor. […] If the high cortisol is not treated, high blood pressure or other heart problems, diabetes, and thinning bones (called osteoporosis) may get worse over time.

• #45 Cushing syndrome – Symptoms and causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/cushing-syndrome/symptoms-causes/syc-20351310

  Other possible symptoms of Cushing syndrome include extreme tiredness, muscle weakness, depression, anxiety and irritability, emotions that are hard to control, trouble concentrating or remembering, sleeplessness, high blood pressure, headache, infections, skin darkening, bone loss, which can lead to broken bones, and stunted growth in children. […] Without treatment, Cushing syndrome can cause complications, including bone loss, also called osteoporosis, which can lead to broken bones, high blood pressure, type 2 diabetes, serious or multiple infections, and loss of muscle mass and strength.

• #46 Symptoms of Cushing’s Disease – Pituitary Foundation

  https://www.pituitary.org.uk/information/cushings-symptoms/

  You may be feeling generally unwell, and more susceptible to infections. […] Mood swings such as being more irritable, feeling depressed or anxious. In some cases, psychological problems can be severe, even being diagnosed as a nervous breakdown. […] In children it may show itself by growth stopping and weight increasing. […] Cushings affects many parts of the body, both mentally and physically, and affects different people in different ways. […] Because Cushings can progress slowly and gradually, it can go unrecognised for quite some time. Looking back, many patients realise that there were clues to the condition two or more years before they were referred to an endocrinologist. However, lack of Cushings knowledge at the time meant they were unaware of the condition.

• #47 Cushing’s Disease – Pituitary Foundation

  https://www.pituitary.org.uk/information/cushings-disease/

  Cushing’s disease is a condition caused by having too much of a hormone called cortisol in your body. Symptoms usually develop gradually and so the diagnosis may not be clear for some time. […] The symptoms of Cushings can be very wide ranging and thus the diagnosis may not necessarily be considered. It can also be difficult to establish at the earlier stages and this can cause a delay in diagnosis. […] There are a wide range of varied symptoms for Cushings. […] Due to the range of symptoms that occur over a long time. […] Cushing’s disease is a condition caused by having too much of a hormone called cortisol in your body.

• #48 Cushing’s Syndrome: Causes, Symptoms, and Treatment

  https://patient.info/hormones/cushings-syndrome-leaflet

  In most cases (apart from when steroid medication is the cause), the symptoms develop gradually. The diagnosis is often not clear for quite some time, sometimes years, after symptoms first begin. […] This is because most of the symptoms can also be caused by other common problems. For example, although most people with Cushing’s syndrome have obesity, most people with obesity do not have Cushing’s syndrome. Likewise, high blood pressure is common but Cushing’s syndrome is a rare cause of it. […] Also, the symptoms can be fairly nonspecific at first. For example, you may put on some weight, have mood swings and just not feel right. However, it is difficult to say why. You may even be treated for depression or obesity before the cause of your symptoms becomes clear.

• #49 Cushing’s Syndrome: Causes, Symptoms, and Treatment

  https://patient.info/hormones/cushings-syndrome-leaflet

  Cushing’s syndrome is caused by too high a level of glucocorticoid in the body. This can be caused by taking steroid medication long-term (the common cause) or by the body making too much cortisol (the main glucocorticoid made by the body). […] Symptoms usually develop gradually and so the diagnosis (other than that caused by steroid medication) may not be clear for some time. […] The symptoms that are said to be the most indicative of Cushing’s syndrome are: Easy bruising. Facial redness (plethora). Proximal muscle weakness. Stretch marks (striae) – especially if reddish purple and more than 1 cm wide. In children, weight gain but being short for their age. […] Symptoms of Cushing’s syndrome occur because you have too much cortisol in your body over a long period of time. In most cases, several of the symptoms listed below develop, although you are unlikely to have them all: Fat deposits build up on the side of the skull in the facial area, causing the appearance of a round, full, and puffy face. This used to be likened to a moon face. Fat may accumulate at the upper back and behind the neck. This used to be inappropriately likened to a buffalo hump. Facial puffiness and the face often looking redder than usual. Diabetes. Facial hair in women. High blood pressure. Muscle weakness. In particular a proximal muscle weakness. The proximal muscles are the ones in your arms and legs nearest to the body. So, the muscles around the thighs, pelvis, shoulders and upper arms are the proximal muscles. Thin skin which bruises easily. Purple/pink stretch marks (striae) may appear – similar to those seen on some pregnant women. Tiredness. Aches and pains – particularly backache. Mood swings – such as being more irritable, depressed or anxious than usual. Lack of sex drive (loss of libido). Periods may become irregular, or stop, in women. 'Thinning’ of the bones (osteoporosis). You may fracture a bone more easily than usual. 'Water retention’ (oedema) around the ankles. Excess thirst. Increased susceptibility to infections. Affected children tend to be obese but grow slowly so are short for their age.

• #50 Symptoms of Cushing’s Disease – Pituitary Foundation

  https://www.pituitary.org.uk/information/cushings-symptoms/

  You may be feeling generally unwell, and more susceptible to infections. […] Mood swings such as being more irritable, feeling depressed or anxious. In some cases, psychological problems can be severe, even being diagnosed as a nervous breakdown. […] In children it may show itself by growth stopping and weight increasing. […] Cushings affects many parts of the body, both mentally and physically, and affects different people in different ways. […] Because Cushings can progress slowly and gradually, it can go unrecognised for quite some time. Looking back, many patients realise that there were clues to the condition two or more years before they were referred to an endocrinologist. However, lack of Cushings knowledge at the time meant they were unaware of the condition.

• #51 Cushing’s Disease: She Mistook Her Symptoms as Signs of Menopause – Pacific Neuroscience Institute

  https://www.pacificneuroscienceinstitute.org/resources/patient-stories/cushings-disease-she-mistook-her-symptoms-as-signs-of-menopause/

  Eight years ago, when Elisabeth N., now 62, started developing symptoms that included obesity, osteoporosis, insomnia, kidney stones and hair loss, she attributed it to what most women her age would: menopause. […] Elisabeth started researching Cushings Syndrome right away and was relieved to learn that a cure was possible. Cushings is a hormonal disorder caused by high levels of the hormone cortisol. Symptoms include upper-body obesity, fragile skin that bruises easily, weakened bones, severe fatigue, weak muscles, high blood pressure, high blood glucose, increased thirst and urination, depression and a fatty hump between the shoulders. Women can also experience irregular menstrual periods and excess hair growth on their bodies. […] Untreated or incompletely treated, Cushings disease is a very serious condition leading to uncontrolled hypertension, diabetes, weight gain and increased mortality. […] Her cortisol levels fell dramatically within 24 hours of surgery. She has remained in remission since then. Now almost 5 years after surgery, she continues to feel like a new person and regularly stays in contact with Dr. Kelly and his office staff.

• #52 What is Cushing’s Syndrome?

  https://www.everydayhealth.com/hormones/cushings-syndrome/guide/

  A small number of people experience whats known as cyclic Cushings syndrome, meaning that symptoms come and go as your bodys cortisol levels become elevated and then return to normal. […] Without treatment, Cushings syndrome can lead to serious complications, including high blood pressure, blood clots, type 2 diabetes, osteoporosis, and infections.

• #53 Cushing’s Disease Symptoms & Treatment – Pituitary & Skull Base Tumor | UCLA Health

  https://www.uclahealth.org/medical-services/neurosurgery/pituitary-skull-base-tumor/conditions/pituitary-adenomas/cushings-disease

  High blood pressure that is often difficult to treat […] Diabetes mellitus, often severe […] Mood and behavior disorders; some patients have psychiatric disorders that require hospitalization […] Although uncommon, some patients with Cushing’s disease have large pituitary tumors (macroadenomas). […] In addition to the severe hormonal effects related to increase blood cortisol levels, the large tumor can compress adjacent structures leading to: […] Vision loss […] When large pituitary adenomas (macroadenomas) grow upward into the brain cavity, the tumor can elevate and compress the optic chiasm, the part of the brain where the optic nerves partially cross. […] A loss of the outer peripheral vision occurs, called a bitemporal hemianopsia […] Increased compression of the normal gland can cause hormone insufficiency, called hypopituitarism. […] The early stages of Cushing’s disease may be difficult to recognize, especially because the body changes develop slowly. […] The diagnosis may be difficult to make because sometimes the hormone elevations come and go: so called „cyclic” or „periodic” Cushing’s disease.

• #54 Iatrogenic Cushing Syndrome: Practice Essentials, Frequency, Mortality/Morbidity

  https://emedicine.medscape.com/article/117365-overview

  Untreated Cushing syndrome is associated with a 5-year mortality rate of 50%. This reflects a four- to five-fold increase in mortality over the general population and is attributable to factors such as cardiovascular complications, thromboembolic events, opportunistic infections, and suicide. […] Exogenous steroids suppress the hypothalamic-pituitary-adrenal (HPA) axis, with full recovery taking as long as a year after cessation of glucocorticoid administration. Thus, patients who are on or who have taken steroids are at risk for developing an adrenal crisis if steroids are stopped abruptly or are not increased appropriately during an acute illness.

• #55 Cushing Syndrome – UF Health

  https://ufhealth.org/conditions-and-treatments/cushing-syndrome

  Not everyone with Cushing syndrome has the same symptoms. Some people have many symptoms while others have hardly any symptoms. Symptoms usually get worse over time. […] Most people with Cushing syndrome have: Round, red, full face (moon face) […] Weight gain with fat accumulation on the trunk, but fat loss from the arms, legs, and buttocks (central obesity) […] Skin changes can include: Purple stretch marks (1/2 inch or 1 centimeter or more wide) called striae on the skin of the abdomen, upper arms, thighs, and breasts […] Muscle and bone changes include: Backache, which occurs with routine activities […] Weak muscles, especially of the hips and shoulders […] Body-wide (systemic) changes include: Type 2 diabetes mellitus […] High blood pressure (hypertension) […] Other symptoms that may occur with this disease: Mental changes, such as depression, anxiety, or changes in behavior […] Fatigue […] Increased thirst and urination

• #56 Signs and Symptoms of Cushing Syndrome – Cortisol Matters

  https://www.cortisolmatters.com/patient/cushing-syndrome-symptoms

  Symptoms of Cushing syndrome (hypercortisolism) vary from person to person. Everyone may experience symptoms of Cushing syndrome differently and at varying levels of severity. Some common signs and symptoms include: […] About 70% to 75% of people with Cushing syndrome have problems controlling their blood sugar. […] More than 80% of people with Cushing syndrome have weight gain and changes in appearance. […] At least 70% of people with Cushing syndrome have depression or cognitive changes (such as changes in mood, concentration, or memory). […] 66% to 79% of people with Cushing syndrome have anxiety. […] People with Cushing syndrome are at increased risk for heart disease and stroke. […] As Cushing syndrome gets worse, the body may become increasingly susceptible to new or worsening infections.

• #57 Patient education: Cushing syndrome (Beyond the Basics) – UpToDate

  https://www.uptodate.com/contents/cushings-syndrome-beyond-the-basics

  Infections — Cortisol excess suppresses the immune system, and people with Cushing syndrome may develop infections more frequently. […] Blood clots — People with Cushing syndrome tend to form blood clots more easily. A blood clot in a leg vein is called a deep vein thrombosis (DVT). If a DVT breaks off and travels to the lungs, this is called a pulmonary embolism (PE). A pulmonary embolism is a serious and life-threatening condition. People with Cushing syndrome also are more likely to develop stroke from a blood clot.

• #58 Patient education: Cushing syndrome (Beyond the Basics) – UpToDate

  https://www.uptodate.com/contents/cushings-syndrome-beyond-the-basics

  Infections — Cortisol excess suppresses the immune system, and people with Cushing syndrome may develop infections more frequently. […] Blood clots — People with Cushing syndrome tend to form blood clots more easily. A blood clot in a leg vein is called a deep vein thrombosis (DVT). If a DVT breaks off and travels to the lungs, this is called a pulmonary embolism (PE). A pulmonary embolism is a serious and life-threatening condition. People with Cushing syndrome also are more likely to develop stroke from a blood clot.

• #59 Patient education: Cushing syndrome (Beyond the Basics) – UpToDate

  https://www.uptodate.com/contents/cushings-syndrome-beyond-the-basics

  Infections — Cortisol excess suppresses the immune system, and people with Cushing syndrome may develop infections more frequently. […] Blood clots — People with Cushing syndrome tend to form blood clots more easily. A blood clot in a leg vein is called a deep vein thrombosis (DVT). If a DVT breaks off and travels to the lungs, this is called a pulmonary embolism (PE). A pulmonary embolism is a serious and life-threatening condition. People with Cushing syndrome also are more likely to develop stroke from a blood clot.

• #60 Cushing’s Syndrome

  https://resources.healthgrades.com/right-care/endocrinology-and-metabolism/cushings-syndrome

  Serious complications of Cushing’s syndrome include kidney stones, hyperglycemia (high blood sugar), and hypertension (high blood pressure). […] Untreated Cushing’s syndrome can lead to serious complications. You can help minimize complications of Cushing’s syndrome by following the treatment plan you and your doctor design specifically for you. Complications of Cushing’s syndrome include: Anxiety, Depression, Diabetes, Frequent infections, Hypertension, Infertility, Kidney stones, Male impotence, Osteoporosis.

• #61 Signs and Symptoms of Cushing Syndrome – Cortisol Matters

  https://www.cortisolmatters.com/patient/cushing-syndrome-symptoms

  24% to 90% of people with Cushing syndrome have a reduced sex drive. […] 50% to 75% of men with Cushing syndrome have low testosterone levels (hypogonadism). […] 43% to 80% of women with Cushing syndrome have irregular menstrual periods. […] The percentage of people with Cushing syndrome who have bone loss and spinal fractures may be as high as 10.8%. […] About 73% of people with Cushing syndrome have changes to their skin. […] As Cushing syndrome worsens, muscle mass shrinks. […] The condition tends to worsen over time. […] The longer a person is exposed to excess cortisol, the worse the symptoms may become. […] Symptoms of Cushing syndrome may differ from person to person. […] No single sign or symptom points to a diagnosis. […] Some symptoms of Cushing syndrome are more obvious than others.

• #62 Cushing syndrome – Symptoms and causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/cushing-syndrome/symptoms-causes/syc-20351310

  Other possible symptoms of Cushing syndrome include extreme tiredness, muscle weakness, depression, anxiety and irritability, emotions that are hard to control, trouble concentrating or remembering, sleeplessness, high blood pressure, headache, infections, skin darkening, bone loss, which can lead to broken bones, and stunted growth in children. […] Without treatment, Cushing syndrome can cause complications, including bone loss, also called osteoporosis, which can lead to broken bones, high blood pressure, type 2 diabetes, serious or multiple infections, and loss of muscle mass and strength.

• #63 Reddit – The heart of the internet

  https://www.reddit.com/r/Cushings/comments/1hql5jc/cushings_symptoms_list/

  Hypokalemia: Cushing’s syndrome often causes low potassium levels due to the effects of excess cortisol or, in some cases, excess aldosterone-like activity. Low potassium can lead to muscle cramps, spasms, and even weakness. […] Delayed wound healing (I have this so bad. Any cut scars.) […] Skin atrophy (thin, fragile skin with visible veins) […] Hyperhidrosis (excessive sweating) […] Excessive hairiness (hirsutism) I went from no body hair to covered in it. And it isn’t even. It is an ugly different length spotty mess. […] A flushed, reddish complexion, especially noticeable on the cheeks and upper face I had a red face with the rest of my body being nowhere near as red. […] Often accompanied by the „moon face” typical of Cushings, where the face appears rounded and swollen I have the typical rounded moon face.

• #64 Reddit – The heart of the internet

  https://www.reddit.com/r/Cushings/comments/1hql5jc/cushings_symptoms_list/

  Buffalo hump or fat on the back of neck on your spine that looks like a hump. […] Extreme Thirst Due to electrolyte imbalance I used to drink sometimes 2 gallons of water a day. […] Palpitations due to electrolyte imbalances (e.g., hypokalemia) […] New or worsened high blood pressure […] Chronic irritability and frustration or Loss of emotional control (Whenever I was sick I would lose control of my emotions and the smallest thing would piss me off to no end. I once went on a half an hour rant about how some product was deceptive. It was a $2 purchase. Towards the end I realized something was wrong with me.) […] Sudden cardiac events due to severe electrolyte disturbances […] Low Vitamin D These are common but were great clues in figuring out Cushing’s. […] Low Potassium

• #65 Iatrogenic Cushing Syndrome: Practice Essentials, Frequency, Mortality/Morbidity

  https://emedicine.medscape.com/article/117365-overview

  Untreated Cushing syndrome is associated with a 5-year mortality rate of 50%. This reflects a four- to five-fold increase in mortality over the general population and is attributable to factors such as cardiovascular complications, thromboembolic events, opportunistic infections, and suicide. […] Exogenous steroids suppress the hypothalamic-pituitary-adrenal (HPA) axis, with full recovery taking as long as a year after cessation of glucocorticoid administration. Thus, patients who are on or who have taken steroids are at risk for developing an adrenal crisis if steroids are stopped abruptly or are not increased appropriately during an acute illness.

• #66 Early Identification of Cushing’s Syndrome in Children – CSRF – Cushing’s Support & Research Foundation

  https://csrf.net/understanding-cushings/pediatric-cushings/early-identification/

  The most common cause of endogenous Cushings syndrome in children is an ACTH-secreting pituitary adenoma (accounts for approximately 75% of all cases of endogenous Cushings syndrome in children older than 7 years) […] The most common cause of Cushings syndrome in infants and toddlers is an adrenal tumor (adenoma, carcinoma, or bilateral hyperplasia). […] Growth failure (or deceleration) associated with weight gain is a hallmark feature of Cushings syndrome in children. Other sign and symptoms often seen in children and adolescents with Cushings syndrome include facial plethora, increased fine downy hair on the face, body and extremities, a temporal fat pad, round face, diabetes and other symptoms listed below. […] Presenting Symptoms Signs of Cushings Syndrome: Weight Gain 90, Growth Retardation 83, Menstrual Irregularities 81, Hirsuitism 81, Obesity (BMI 85th percentile) 73, Violaceous skin striae 63, Acne 52, Hypertension 51, Fatigue-weakness 45, Precocious puberty 41, Bruising 27, Mental Changes 18, Delayed bone age 14, Hyperpigmentation 13, Muscle weakness 13, Acanthosis nigricans 10, Accelerated bone age 10, Sleep disturbances 7, Pubertal Delay 7, Hypercalcemia 6, Alkalosis 6, Hypokalemia 2, Slipped femoral capital epephysis 2.

• #67 Cushing Syndrome (for Parents) | Nemours KidsHealth

  https://kidshealth.org/en/parents/cushing-syndrome.html

  Symptoms of Cushing syndrome might take months to develop. They can include: a round face, a fatty hump between the shoulders and neck, weight gain, growth problems, red or purple stretch marks, thin skin that bruises easily, tiredness, acne, high blood pressure, type 2 diabetes, thicker, more noticeable facial hair in girls (hirsutism), bone problems, muscle weakness, behavior changes. […] A doctor may suspect Cushing syndrome if a person has the telltale signs, such as a rounded face, a pad of fatty tissue between the shoulders, thin skin with bruises and stretch marks, and poor growth. […] In children, doctors might suspect Cushing syndrome when a child is gaining weight but not growing as expected.

• #68 Cushing’s Syndrome | Children’s Hospital of Philadelphia

  https://www.chop.edu/conditions-diseases/cushing-s-syndrome

  Cushings syndrome, also called hypercortisolism, is a condition in which the body produces too much of the hormone cortisol. […] The primary symptoms of Cushings syndrome in children who are still growing is a dramatic slowing in vertical growth, while the child continues to gain weight. […] Some children will also experience a variety of other symptoms including: Easy bruising, Emotional changes such as depression and moodiness, Weakened bones, Muscle weakness, Late or delayed puberty, Sleep disturbances, Hypercalcemia (extra calcium in the blood), Kidney stones (calcium that comes from the bones leaks through the kidneys into the urine and can crystallize, causing calcium stones). […] Cushings syndrome may require lifelong treatment. […] Children with Cushings syndrome should follow-up with the endocrinologist every three to six months to monitor hormone levels, adjust medication as needed, and measure the effectiveness of treatment.

• #69 What are the symptoms of Cushing syndrome? | NICHD – Eunice Kennedy Shriver National Institute of Child Health and Human Development

  http://www.nichd.nih.gov/health/topics/cushing/conditioninfo/symptoms

  Cushing syndrome can cause a range of symptoms. The symptoms might also be similar to those of other conditions. Physically, someone with Cushing syndrome might have: Having overweight or obesity above the waist but thin arms and legs. A round, red face, sometimes referred to as a moon face. A fat lump between the shoulders, sometimes called a buffalo hump. Weak muscles or bones including osteoporosis, bone pain, and fractures. Skin changes, including: New or worsened acne or skin infections. Reddish-purple stretch marks called striae. These are usually about half an inch wide and can appear on the abdomen, buttocks, thighs, arms, and breasts. Thin, fragile skin that bruises easily and heals poorly. […] Additional symptoms can include the following: Children may get heavier but grow more slowly than their peers. Women may have more hair on their face, neck, chest, abdomen, and thighs. They may experience menstrual problems, such as irregular or stopped periods. Men may have lower sex drive, experience impotence, and become less fertile.

• #70 Cushing’s Syndrome | Children’s Hospital of Philadelphia

  https://www.chop.edu/conditions-diseases/cushing-s-syndrome

  Cushings syndrome, also called hypercortisolism, is a condition in which the body produces too much of the hormone cortisol. […] The primary symptoms of Cushings syndrome in children who are still growing is a dramatic slowing in vertical growth, while the child continues to gain weight. […] Some children will also experience a variety of other symptoms including: Easy bruising, Emotional changes such as depression and moodiness, Weakened bones, Muscle weakness, Late or delayed puberty, Sleep disturbances, Hypercalcemia (extra calcium in the blood), Kidney stones (calcium that comes from the bones leaks through the kidneys into the urine and can crystallize, causing calcium stones). […] Cushings syndrome may require lifelong treatment. […] Children with Cushings syndrome should follow-up with the endocrinologist every three to six months to monitor hormone levels, adjust medication as needed, and measure the effectiveness of treatment.

• #71 Cushing’s Syndrome | UTHealth Houston Neurosciences

  https://med.uth.edu/neurosciences/cushings-syndrome/

  Patients typically experience rapid weight gain and notice fatty tissue deposits in the face, midsection, and upper back. […] They might experience fatigue, depression, anxiety, and loss of emotional regulation. Headaches, cognitive difficulties, and high blood pressure are also common symptoms. […] People with Cushings syndrome tend to heal slowly from cuts, bites, and infections. Skin may appear flushed, bruise easily and show stretch marks. Other symptoms include increased acne and body hair. […] Children might experience impeded growth and frequent bone fractures. Adults may experience decreased sex drive, decreased fertility, erectile dysfunction, or irregular menstrual cycles.

• #72 Cushing’s Syndrome | Boston Children’s Hospital

  https://www.childrenshospital.org/conditions/cushings-syndrome

  Children and adolescents with Cushing’s syndrome experience weight gain, growth retardation and hypertension (high blood pressure). Other symptoms may include: […] Upper body obesity […] Round or moon-shaped face […] Increased fat around neck […] Thinning arms and legs […] Fragile and thin skin […] Darkened pigmentation of the skin […] Acne […] Bruising […] Stretch marks on abdomen, thighs, buttocks, arms, and breasts […] Bone and muscle weakness […] Severe fatigue […] High blood sugar […] Irritability and anxiety […] Excessive hair growth in females […] Irregular or stopped menstrual cycles in females […] Reduced sex drive and fertility in males.

• #73 Cushing syndrome – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/cushing-syndrome/diagnosis-treatment/drc-20351314

  When Cushing syndrome is caused by the body making too much cortisol, it can be hard to diagnose. […] The endocrinologist likely will do a physical exam and look for signs of Cushing syndrome, such as a round face, a hump on the back of the neck, and thin, bruised skin with stretch marks. […] These tests help your health care provider diagnose Cushing syndrome. They also may help rule out other health conditions, such as polycystic ovary syndrome a hormone problem in people with enlarged ovaries. […] If Cushing syndrome is caused by taking glucocorticoid medicine for a long time, your health care provider may be able to control your symptoms by lowering how much medicine you take. […] If Cushing syndrome is caused by a tumor, your health care provider may recommend removing the tumor with surgery.

• #74 Cushing’s Syndrome | Skull Base Surgery | Stanford Medicine

  https://med.stanford.edu/skullbasesurgery/conditions-we-treat/cushings-disease.html

  Cushing’s syndrome is a rare problem that happens when you have too much of the hormone cortisol in your body. […] The symptoms of Cushing’s syndrome vary and often appear slowly over time. […] You may have: Weight gain, especially around the waist. This is the most common symptom. You might also have a round face or extra fat around the neck and upper part of the back (buffalo hump). […] Cushing’s syndrome can also lead to other health problems, such as high blood pressure, type 2 diabetes, glaucoma, and cataracts. […] If a pituitary tumor is the cause: Surgery to remove the tumor offers the best chance for recovery. […] If an adrenal tumor is the cause: Surgery to remove the tumor is usually done if the tumor is not cancer (benign). If the tumor is cancer, the whole gland is removed.

• #75 Cushing’s Disease | Neurological Surgery

  https://neurosurgery.weillcornell.org/condition/cushings-disease

  Cushings disease is a disorder of the pituitary gland in which too much adrenocorticotropic hormone (ACTH) is produced by a pituitary tumor, which in turn stimulates excess production of the stress hormone cortisol. […] An individual exposed to excess cortisol levels on an ongoing basis may develop a characteristic moon face (moon facies), upper-body obesity and fat deposits, muscle weakness, and bone thinning, among other symptoms. […] Left untreated, Cushings disease can ultimately be fatal, but fortunately there are effective treatments for the disorder. […] Cushings disease is most often caused by a benign pituitary tumor that produces ACTH, leading to excess of cortisol. Removing the tumor often halts the condition and reverses many of the symptoms.

• #76 Mild Cases of Cushing’s Syndrome Present Diagnostic Challenges – Endocrinology Advisor

  https://www.endocrinologyadvisor.com/adrenal/mild-cases-of-cushings-syndrome-present-diagnostic-challenges/

  When surgery is unsuccessful, contraindicated, or delayed, other treatment options include radiation or medications that inhibit cortisol, modulate the release of ACTH, or inhibit steroidogenesis. […] It is also important to inquire about and address psychiatric symptoms related to Cushings syndrome, even in patients who are in remission. […] Milder cases of Cushings syndrome present diagnostic challenges are a result overlapping features with various other conditions. Diagnosis may require careful observation as well as biochemical and imaging tests.

• #77 Mild Cases of Cushing’s Syndrome Present Diagnostic Challenges – Endocrinology Advisor

  https://www.endocrinologyadvisor.com/adrenal/mild-cases-of-cushings-syndrome-present-diagnostic-challenges/

  When surgery is unsuccessful, contraindicated, or delayed, other treatment options include radiation or medications that inhibit cortisol, modulate the release of ACTH, or inhibit steroidogenesis. […] It is also important to inquire about and address psychiatric symptoms related to Cushings syndrome, even in patients who are in remission. […] Milder cases of Cushings syndrome present diagnostic challenges are a result overlapping features with various other conditions. Diagnosis may require careful observation as well as biochemical and imaging tests.

• #78 Cushing syndrome – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/cushing-syndrome/diagnosis-treatment/drc-20351314

  When Cushing syndrome is caused by the body making too much cortisol, it can be hard to diagnose. […] The endocrinologist likely will do a physical exam and look for signs of Cushing syndrome, such as a round face, a hump on the back of the neck, and thin, bruised skin with stretch marks. […] These tests help your health care provider diagnose Cushing syndrome. They also may help rule out other health conditions, such as polycystic ovary syndrome a hormone problem in people with enlarged ovaries. […] If Cushing syndrome is caused by taking glucocorticoid medicine for a long time, your health care provider may be able to control your symptoms by lowering how much medicine you take. […] If Cushing syndrome is caused by a tumor, your health care provider may recommend removing the tumor with surgery.

• #79 Cushing syndrome – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/cushing-syndrome/diagnosis-treatment/drc-20351314

  After Cushing syndrome surgery, your body won’t make enough ACTH. […] Recovery from Cushing syndrome is usually a slow, gradual process. It can take time before you start to feel better. […] Depression can be a side effect of Cushing syndrome, but it also can continue or start after treatment begins.

• #80 Cushing Syndrome: Causes, Symptoms & Treatment

  https://my.clevelandclinic.org/health/diseases/5497-cushing-syndrome

  Cushing syndrome is a condition caused by too much of the hormone cortisol in the body. There are treatments for Cushing syndrome. Treatment may last for some time. […] Cushing syndrome affects several body systems, causing a multitude of symptoms. Cushing syndrome has some unique symptoms as well as some that could point towards a variety of other syndromes. Not everyone has the same symptoms. Possible characteristics include: Rapid weight gain in the face (sometimes called moon face), abdomen, back of the neck (sometimes called buffalo hump) and chest. A red, round face. Wounds that heal poorly. High blood pressure (hypertension). Excessive hair growth on the face, neck, chest, abdomen, breasts and thighs, or balding. Diabetes. […] How long Cushing syndrome lasts depends on how you respond to treatment. Many people with hypercortisolism recover after several weeks of treatment. […] Cushing syndrome can get worse without proper treatment. Be sure to stay in contact with your healthcare provider and report any new or worsening symptoms or any other concerns you may have.

• #81 Adrenal Cushing’s Syndrome | Saint John’s Cancer Institute

  https://www.saintjohnscancer.org/endocrine/conditions/cushings-syndrome-adrenal/

  Many Cushing syndrome symptoms will go away after treatment, but this will most likely happen over time up to 18 months. Weight loss, changing face shape, and reduced bruising are usually first. Additionally, if you have had long-standing issues caused by Cushings syndrome, there may be some long-term effects that require monitoring. Lastly, increased cortisol levels may have suppressed some autoimmune disorders. Once cortisol levels are normal, the disorders may come back.

• #82 Adrenal Cushing’s Syndrome | Saint John’s Cancer Institute

  https://www.saintjohnscancer.org/endocrine/conditions/cushings-syndrome-adrenal/

  Some patients will present with little to no symptoms. However, lab results may indicate an underlying problem categorized as subclinical Cushings and should still be considered for treatment. […] Common symptoms may include: High blood pressure, Diabetes, Moon facies (round facial shape), Buffalo hump (mound of fat at the back of the neck), Stretch marks, Abnormal hair growth, Osteoporosis, Easy bruising, Fatigue, Weight gain (particularly around the mid-section), Swelling in the legs, Mood swings, Irregular periods, Muscle weakness, Mental fogginess. […] Regardless of the cause, the symptoms are the same. However, many are either non-specific, common complaints or medical conditions and therefore the diagnosis is not always straight forward. […] Over time, many symptoms will resolve themselves. Weight loss, bruising, and a rounding face generally occur first. However, your body needs time to re-regulate itself, so these changes do not happen overnight. For instance, if you have newly diagnosed diabetes and/or high blood pressure that was caused by Cushings, they will likely improve over time and for a good number of patients, you will return to your pre-Cushings state. However, if conditions have been long-standing, there may be some lasting effects and therefore close monitoring by a medical professional is needed.

• #83 Cushing’s Disease – Causes, Symptoms & Treatment | MedStar Health

  https://www.medstarhealth.org/services/cushings-disease

  Not every individual diagnosed with this disease will experience the same symptoms. Symptoms, and their severity, will vary from person to person. […] In general, symptoms may include: Obesity above the waist, while maintaining thin arms and legs, A round, fuller face, Excess fat on the back of the neck, Acne, Skin that bruises easily, Mood changes, like depression or anxiety, Weakened bones, Bone pain, Weakened muscles, Stretch marks (striae) on the abdomen, thighs, and/or breasts, In children, slow growth rate accompanied by obesity. […] Women may experience: Excess hair growth on the stomach and face, Irregular menstrual cycle or one that stops. […] Men may experience: Impotence, Decreased libido. […] Recovery can take as long as one to two years. This is because this condition affects every system in the body.

• #84 Managing Your Cushing’s Syndrome – Symptoms & Treatment | Carle.org

  https://carle.org/conditions/managing-your-cushing-s-syndrome

  Symptoms are weight gain, rounded face, fat around the neck, and thin arms and legs. Children are obese and grow slowly. The stomach, legs, arms, and breasts may show purplish-pink stretch marks. Thin, delicate skin bruises easily and heals poorly. Bones are weak and brittle and may break. Hormonal changes in women mean that they usually have too much hair growth on the face, neck, chest, stomach, and thighs. Periods may be irregular or stop. Men may be impotent. Other symptoms are urinating often, severe tiredness, weak muscles, high blood pressure, personality changes, and feeling irritable, anxious, and depressed. […] Recovery time depends on duration of the illness, cortisol levels, and basic health.

• #85 What is Cushing Disease? | Orlando | UCF Health

  https://ucfhealth.com/our-services/endocrinology/cushing-disease/

  A person with high cortisol levels may feel weak and fatigued often. Cushing disease may even lead to muscular dystrophy if left untreated. Muscle weakness can unfortunately persist even after the syndrome is treated, so its essential to catch this disease as soon as possible. […] Cushings disease is known to cause severe depression, irritability, anxiety, and mood swings, as well as decreased fertility and/or libido. […] Over time, Cushing disease may lead to type 2 diabetes, heart disease, cause menstrual disorders in women, vertigo, brittle bones, and sleep disorders and/or sleep apnea. […] Cortisol plays a role in all of our critical functions, so having abnormally high cortisol levels can have a significant impact on every aspect of life from your mood, to your strength, sleep quality, and overall health.

• #86 Cushing syndrome – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/cushing-syndrome/diagnosis-treatment/drc-20351314

  After Cushing syndrome surgery, your body won’t make enough ACTH. […] Recovery from Cushing syndrome is usually a slow, gradual process. It can take time before you start to feel better. […] Depression can be a side effect of Cushing syndrome, but it also can continue or start after treatment begins.

• #87 Mild Cases of Cushing’s Syndrome Present Diagnostic Challenges – Endocrinology Advisor

  https://www.endocrinologyadvisor.com/adrenal/mild-cases-of-cushings-syndrome-present-diagnostic-challenges/

  When surgery is unsuccessful, contraindicated, or delayed, other treatment options include radiation or medications that inhibit cortisol, modulate the release of ACTH, or inhibit steroidogenesis. […] It is also important to inquire about and address psychiatric symptoms related to Cushings syndrome, even in patients who are in remission. […] Milder cases of Cushings syndrome present diagnostic challenges are a result overlapping features with various other conditions. Diagnosis may require careful observation as well as biochemical and imaging tests.

• #88 Cushing’s syndrome: when cortisol floods the blood – USZ

  https://www.usz.ch/en/disease/cushings-syndrome/

  If too much of the hormone cortisol circulates in your body for a long time, you could develop Cushing’s syndrome. Signs include weight gain, high blood pressure, muscle weakness and the development of a so-called moon face and bull neck. […] The main symptoms of Cushings syndrome are as follows: trunk obesity, i.e. fat deposits that mainly form on the trunk of the body, i.e. the upper body, abdomen and hips. Arms and legs are not affected, but are often conspicuously thin due to muscle weakness. […] The typical moon face (facies lunata), i.e. a round, reddened face. […] High blood pressure (hypertension). […] Absence of menstruation (amenorrhea) in women. […] A whole range of other symptoms may occur, but not necessarily. As a rule, they do not all appear at the same time. […] The prognosis for exogenous Cushings syndrome is good. It is crucial to discontinue the triggering drug or reduce its dose. This should be done in consultation with your doctor. The prognosis for endogenous Cushings syndrome depends on how well the triggering disease, usually a tumor, can be treated.

• #89 Cushing’s Syndrome | Baptist Health

  https://www.baptisthealth.com/care-services/conditions-treatments/hormonal/cushings-syndrome

  There are various Cushings Syndrome symptoms. Some of the long-term symptoms are easily observed by doctors. […] Typical signs of Cushings Syndrome: Muscle weakness, Rounded face, Weight increase, High blood pressure, Thinner legs, Thinner arms, Stretch marks, Headaches, Neck fat, Humped back, Fragile skin, Bruises. […] Symptoms in Children: Obesity, Slow growth. […] Symptoms in Women: Body hair growth, Facial hair growth, Irregular menstruation, Absent menstruation. […] Symptoms in Men: Erectile dysfunction, Reduced sex drive, Lowered fertility. […] The Cushings Syndrome prognosis depends on your general health, the cause of the condition, and the severity of symptoms. The majority of people with Cushings Syndrome can lead normal or near-normal lives.

• #90 Cushing’s syndrome: when cortisol floods the blood – USZ

  https://www.usz.ch/en/disease/cushings-syndrome/

  The course of Cushings syndrome depends on the cause. In most cases, treatment ensures a favorable prognosis: the success rate is between 50 and 80 percent. […] If it occurs as a side effect of long-term treatment with certain medications, for example a glucocorticoid, it disappears again when you stop taking the medication. […] The syndrome can also be cured relatively well with early treatment if it is caused by a benign tumor of the pituitary gland (known as Cushings disease). […] Cushings syndrome, caused by a benign adrenal adenoma, is also relatively easy to cure. […] The prognosis is less positive if the cause was an adrenal carcinoma or another malignant tumor. […] Cushing’s syndrome can cause various complications that affect bone and muscle metabolism, among other things, and manifest themselves in osteoporosis or long-term muscle weakness. If it remains untreated, those affected can even die from it after months or years for example due to infections, changes in blood salts or the consequences of high blood pressure.

• #91 Cushing’s syndrome: when cortisol floods the blood – USZ

  https://www.usz.ch/en/disease/cushings-syndrome/

  The course of Cushings syndrome depends on the cause. In most cases, treatment ensures a favorable prognosis: the success rate is between 50 and 80 percent. […] If it occurs as a side effect of long-term treatment with certain medications, for example a glucocorticoid, it disappears again when you stop taking the medication. […] The syndrome can also be cured relatively well with early treatment if it is caused by a benign tumor of the pituitary gland (known as Cushings disease). […] Cushings syndrome, caused by a benign adrenal adenoma, is also relatively easy to cure. […] The prognosis is less positive if the cause was an adrenal carcinoma or another malignant tumor. […] Cushing’s syndrome can cause various complications that affect bone and muscle metabolism, among other things, and manifest themselves in osteoporosis or long-term muscle weakness. If it remains untreated, those affected can even die from it after months or years for example due to infections, changes in blood salts or the consequences of high blood pressure.

• #92 Adrenal Cushing’s Syndrome | Saint John’s Cancer Institute

  https://www.saintjohnscancer.org/endocrine/conditions/cushings-syndrome-adrenal/

  Some patients will present with little to no symptoms. However, lab results may indicate an underlying problem categorized as subclinical Cushings and should still be considered for treatment. […] Common symptoms may include: High blood pressure, Diabetes, Moon facies (round facial shape), Buffalo hump (mound of fat at the back of the neck), Stretch marks, Abnormal hair growth, Osteoporosis, Easy bruising, Fatigue, Weight gain (particularly around the mid-section), Swelling in the legs, Mood swings, Irregular periods, Muscle weakness, Mental fogginess. […] Regardless of the cause, the symptoms are the same. However, many are either non-specific, common complaints or medical conditions and therefore the diagnosis is not always straight forward. […] Over time, many symptoms will resolve themselves. Weight loss, bruising, and a rounding face generally occur first. However, your body needs time to re-regulate itself, so these changes do not happen overnight. For instance, if you have newly diagnosed diabetes and/or high blood pressure that was caused by Cushings, they will likely improve over time and for a good number of patients, you will return to your pre-Cushings state. However, if conditions have been long-standing, there may be some lasting effects and therefore close monitoring by a medical professional is needed.

• #93 Cushing’s Syndrome – familydoctor.org

  https://familydoctor.org/condition/cushings-syndrome/

  Cushing’s syndrome treatment does not always return people to the same level of health they once had. Their bones may not be as strong. People who no longer have Cushing’s syndrome are at higher risk of developing diabetes, high blood pressure, or high cholesterol. A person cured of Cushing’s syndrome might have some memory loss and slight mental decline. But the change is slight. In rare cases, people who have had surgery to remove a tumor that was causing Cushing’s syndrome never regain normal cortisol levels and must therefore continue to take the cortisol replacement medicine. […] Once you’ve been diagnosed with Cushing’s syndrome and treated, you will need regular checkups for the rest of your life. In rare cases, surgery to remove a tumor may miss some of the tumor and it may grow again.

• #94 Cushing’s Syndrome – familydoctor.org

  https://familydoctor.org/condition/cushings-syndrome/

  Cushing’s syndrome treatment does not always return people to the same level of health they once had. Their bones may not be as strong. People who no longer have Cushing’s syndrome are at higher risk of developing diabetes, high blood pressure, or high cholesterol. A person cured of Cushing’s syndrome might have some memory loss and slight mental decline. But the change is slight. In rare cases, people who have had surgery to remove a tumor that was causing Cushing’s syndrome never regain normal cortisol levels and must therefore continue to take the cortisol replacement medicine. […] Once you’ve been diagnosed with Cushing’s syndrome and treated, you will need regular checkups for the rest of your life. In rare cases, surgery to remove a tumor may miss some of the tumor and it may grow again.

• #95 What is Cushing syndrome? – Harvard Health

  https://www.health.harvard.edu/diseases-and-conditions/what-is-cushing-syndrome

  Left untreated, Cushing syndrome increases the risk of hypertension, diabetes, skeletal fractures, blood clots, heart attack, stroke, and increased risk of infections. […] Dr. Nachtigall points out that many people have symptoms of Cushing syndrome for years before they are diagnosed. […] Cushing syndrome may come back, even years later. Being aware of the symptoms of Cushing syndrome, and getting treated early, can help prevent long-term effects.

• #96 Cushing’s Disease – Symptoms & Causes | Expert Surgeon | Aaron Cohen-Gadol, MD | Aaron Cohen-Gadol, MD

  https://www.aaroncohen-gadol.com/en/patients/cushings-disease/overview

  Very large pituitary tumors (macroadenomas) can cause additional symptoms by compressing nearby structures in the head. […] The recovery outlook for Cushings disease depends on the size of the tumor and stage of disease progression. If treatment such as surgery and in the case of small tumors (microadenomas) adequately removes the tumor, patients can expect to return to generally healthy and normal lives. […] Pituitary surgery can cure or improve symptoms in 80-85% of patients. […] Aside from symptoms such as weakness and fatigue, recurrence of the tumor can lead to significant physical changes. These can include rapid weight gain, excessive hair growth, acne, and a rounder and redder face. Over time, treatment can potentially lessen these symptoms. […] Cushing syndrome can worsen and be potentially fatal if left untreated.

• #97 Cushing syndrome – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/cushing-syndrome/diagnosis-treatment/drc-20351314

  When Cushing syndrome is caused by the body making too much cortisol, it can be hard to diagnose. […] The endocrinologist likely will do a physical exam and look for signs of Cushing syndrome, such as a round face, a hump on the back of the neck, and thin, bruised skin with stretch marks. […] These tests help your health care provider diagnose Cushing syndrome. They also may help rule out other health conditions, such as polycystic ovary syndrome a hormone problem in people with enlarged ovaries. […] If Cushing syndrome is caused by taking glucocorticoid medicine for a long time, your health care provider may be able to control your symptoms by lowering how much medicine you take. […] If Cushing syndrome is caused by a tumor, your health care provider may recommend removing the tumor with surgery.

• #98 Mild Cases of Cushing’s Syndrome Present Diagnostic Challenges – Endocrinology Advisor

  https://www.endocrinologyadvisor.com/adrenal/mild-cases-of-cushings-syndrome-present-diagnostic-challenges/

  Milder cases of Cushings syndrome present diagnostic challenges and may require careful observation as well as biochemical and imaging tests. […] Common signs and symptoms include central adiposity, roundness of the face or extra fat around the neck, thin skin, impaired short-term memory and concentration, irritability, hirsutism in women, fatigue, and menstrual irregularity. […] It can be challenging to differentiate the milder forms from pseudo-Cushings states, which are characterized by altered cortisol production and many of the same clinical features as Cushings syndrome. […] If Cushings syndrome is suspected on the basis of the patients physical appearance, the diagnostic workup should include a thorough medical history, physical exam, and 1 or more of the following tests to establish hypercortisolism: the 24-hour urinary cortisol test, the low-dose dexamethasone suppression test, or the late-night salivary cortisol test.

• #99 Cushing’s Syndrome: Causes, Symptoms, and Treatment

  https://patient.info/hormones/cushings-syndrome-leaflet

  In most cases (apart from when steroid medication is the cause), the symptoms develop gradually. The diagnosis is often not clear for quite some time, sometimes years, after symptoms first begin. […] This is because most of the symptoms can also be caused by other common problems. For example, although most people with Cushing’s syndrome have obesity, most people with obesity do not have Cushing’s syndrome. Likewise, high blood pressure is common but Cushing’s syndrome is a rare cause of it. […] Also, the symptoms can be fairly nonspecific at first. For example, you may put on some weight, have mood swings and just not feel right. However, it is difficult to say why. You may even be treated for depression or obesity before the cause of your symptoms becomes clear.

• #100 Cushing’s Syndrome: Causes, Symptoms, and Treatment

  https://patient.info/hormones/cushings-syndrome-leaflet

  In most cases (apart from when steroid medication is the cause), the symptoms develop gradually. The diagnosis is often not clear for quite some time, sometimes years, after symptoms first begin. […] This is because most of the symptoms can also be caused by other common problems. For example, although most people with Cushing’s syndrome have obesity, most people with obesity do not have Cushing’s syndrome. Likewise, high blood pressure is common but Cushing’s syndrome is a rare cause of it. […] Also, the symptoms can be fairly nonspecific at first. For example, you may put on some weight, have mood swings and just not feel right. However, it is difficult to say why. You may even be treated for depression or obesity before the cause of your symptoms becomes clear.

• #101 Mild Cases of Cushing’s Syndrome Present Diagnostic Challenges – Endocrinology Advisor

  https://www.endocrinologyadvisor.com/adrenal/mild-cases-of-cushings-syndrome-present-diagnostic-challenges/

  Milder cases of Cushings syndrome present diagnostic challenges and may require careful observation as well as biochemical and imaging tests. […] Common signs and symptoms include central adiposity, roundness of the face or extra fat around the neck, thin skin, impaired short-term memory and concentration, irritability, hirsutism in women, fatigue, and menstrual irregularity. […] It can be challenging to differentiate the milder forms from pseudo-Cushings states, which are characterized by altered cortisol production and many of the same clinical features as Cushings syndrome. […] If Cushings syndrome is suspected on the basis of the patients physical appearance, the diagnostic workup should include a thorough medical history, physical exam, and 1 or more of the following tests to establish hypercortisolism: the 24-hour urinary cortisol test, the low-dose dexamethasone suppression test, or the late-night salivary cortisol test.

• #102 Cushing’s Disease Symptoms & Treatment – Pituitary & Skull Base Tumor | UCLA Health

  https://www.uclahealth.org/medical-services/neurosurgery/pituitary-skull-base-tumor/conditions/pituitary-adenomas/cushings-disease

  High blood pressure that is often difficult to treat […] Diabetes mellitus, often severe […] Mood and behavior disorders; some patients have psychiatric disorders that require hospitalization […] Although uncommon, some patients with Cushing’s disease have large pituitary tumors (macroadenomas). […] In addition to the severe hormonal effects related to increase blood cortisol levels, the large tumor can compress adjacent structures leading to: […] Vision loss […] When large pituitary adenomas (macroadenomas) grow upward into the brain cavity, the tumor can elevate and compress the optic chiasm, the part of the brain where the optic nerves partially cross. […] A loss of the outer peripheral vision occurs, called a bitemporal hemianopsia […] Increased compression of the normal gland can cause hormone insufficiency, called hypopituitarism. […] The early stages of Cushing’s disease may be difficult to recognize, especially because the body changes develop slowly. […] The diagnosis may be difficult to make because sometimes the hormone elevations come and go: so called „cyclic” or „periodic” Cushing’s disease.

• #103 What is Cushing Disease? | Orlando | UCF Health

  https://ucfhealth.com/our-services/endocrinology/cushing-disease/

  If test results show that Cushings disease is present, the next step will be to uncover the source of high cortisol. This may require further testing, which often includes a petrosal sinus sampling. […] If a case is too far progressed for lifestyle changes to be a sufficient solution on their own, medication or another procedure may be required. […] The earlier your doctor catches hypercortisolism, the easier it is to treat and manage. As Cushings disease progresses, the symptoms become more complex, and can be debilitating. […] Early intervention of Cushings disease will help preserve muscle strength, prevent excessive weight gain, and prevent skin and hair changes.

• #104

• #105 Cushing’s Syndrome (Cushing’s Disease) | Stanford Health Care

  https://stanfordhealthcare.org/medical-conditions/brain-and-nerves/cushings-syndrome.html

  Cushing’s syndrome is a rare problem that happens when you have too much of the hormone cortisol in your body. […] If something upsets this system, your cortisol level can get too high. If it’s high for too long, it can cause symptoms and can lead to serious problems, such as diabetes, high blood pressure, depression, and osteoporosis.

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