Materiały źródłowe

• #1 Mood Disorders: What They Are, Symptoms & Treatment

  https://my.clevelandclinic.org/health/diseases/17843-mood-disorders

  At this time, theres no known way to prevent mood disorders, but many of the related issues may be lessened with treatment. […] Seeking help as soon as symptoms appear can help decrease the disruption to your life.

• #2 Mood Disorders | Mental Health in Adolescents & Teens

  https://www.cincinnatichildrens.org/health/m/mood-disorders

  Preventive measures to reduce the incidence of mood disorders in adolescents are not known at this time. […] However, early detection and intervention can reduce the severity of symptoms, enhance the child’s or adolescent’s normal growth and development and improve quality of life.

• #3 Content – Health Encyclopedia – University of Rochester Medical Center

  https://www.urmc.rochester.edu/encyclopedia/content?contenttypeid=85&contentid=P00759

  At this time, there are no ways to prevent or reduce mood disorders. But early diagnosis and treatment can reduce the severity of symptoms. […] If you or someone you care about has symptoms of a mood disorder, talk to your healthcare provider.

• #4 Bipolar Disorder (Manic Depression): Symptoms & Treatment

  https://my.clevelandclinic.org/health/diseases/9294-bipolar-disorder

  Unfortunately, theres no known way to prevent bipolar disorder because scientists dont know its exact cause. […] But its important to know the signs and symptoms of bipolar disorder and to seek early intervention. […] Regular and continued use of medication can help reduce episodes of mania and depression. By knowing how to recognize the symptoms and triggers of these episodes, theres a better chance for effective treatment and finding coping methods that may prevent long periods of illness, extended hospital stays and suicide.

• #5 Major depressive disorder – Wikipedia

  https://en.wikipedia.org/wiki/Major_depressive_disorder

  Preventive efforts may result in decreases in rates of the condition of between 22 and 38%. […] Since 2016, the United States Preventive Services Task Force (USPSTF) has recommended screening for depression among those over the age 12, provided that it would be diagnosed accurately, treated efficiently, and followed-up as needed; […] Behavioral interventions, such as interpersonal therapy and cognitive-behavioral therapy, are effective at preventing new onset depression. […] The Netherlands mental health care system provides preventive interventions, such as the „Coping with Depression” course (CWD) for people with sub-threshold depression. The course is claimed to be the most successful of psychoeducational interventions for the treatment and prevention of depression (both for its adaptability to various populations and its results), with a risk reduction of 38% in major depression and an efficacy as a treatment comparing favorably to other psychotherapies.

• #6 Prevention programmes for children of parents with a mood/anxiety disorder: Systematic review of existing programmes and meta-analysis of their efficacy – PubMed

  https://pubmed.ncbi.nlm.nih.gov/33410149/

  Objectives: To systematically describe the characteristics and techniques of prevention programmes for children of parents with mood/anxiety disorders. In addition, recruitment approaches and difficulties were identified and a meta-analysis was conducted to examine the efficacy of these prevention programmes. […] Results suggested that recruitment via clinicians was more successful than recruitment via health maintenance organization databases. In a meta-analysis, a significant risk difference was found in favour of prevention programmes on the risk of developing a depressive/anxiety disorder in offspring at short-term (9-18 months follow-up; RR = 0.37, 95% CI [0.21; 0.66]) and long-term follow-up (24 months or longer follow-up; RR = 0.71, 95% CI [0.57; 0.87] and on symptom levels in offspring at post-intervention (SMD = -0.19, 95% CI [-0.36; -0.02]) and at 12-months follow-up (SMD = -0.31, 95% CI [-0.57; -0.06]).

• #7 Prevention programmes for children of parents with a mood/anxiety disorder: Systematic review of existing programmes and meta-analysis of their efficacy – PubMed

  https://pubmed.ncbi.nlm.nih.gov/33410149/

  Preventive interventions for children of parents with mood/anxiety disorders appear to be effective in preventing these disorders in offspring. Available preventive intervention programmes focus mostly on psychoeducation, cognitive-behavioural therapy, and family processes. More effort should be made into describing preventive interventions so that they can be easily implemented by practitioners. Studies should further examine why and for whom preventive interventions for children of parents with mood/anxiety disorders are effective.

• #8 Omega-3 Polyunsaturated Fatty Acids in Prevention of Mood and Anxiety Disorders

  https://www.cpn.or.kr/journal/view.html?doi=10.9758/cpn.2015.13.2.129

  Omega-3 polyunsaturated fatty acids (PUFAs) have a range of neurobiological activities in modulation of neurotransmitters, anti-inflammation, anti-oxidation and neuroplasticity, which could contribute to psychotropic effects. Here we reviewed recent research on the benefits of omega-3 PUFA supplements in prevention against major depression, bipolar disorders, interferon–induced depression patients with chronic hepatitis C viral infection, and posttraumatic stress disorder. […] Nutrition is a modifiable environmental factor that might be important in prevention medicine, which have been applied for many years in the secondary prevention of heart disease with omega-3 PUFAs. This review extends the notion that nutrition in psychiatry is a modifiable environmental factor and calls for more researches on prospective clinical studies to justify the preventive application of omega-3 PUFAs in daily practice.

• #9 Omega-3 Polyunsaturated Fatty Acids in Prevention of Mood and Anxiety Disorders

  https://www.cpn.or.kr/journal/view.html?doi=10.9758/cpn.2015.13.2.129

  Early intervention and primary prevention is considered as the best strategies for the crisis of under-treatment and under-effectiveness because a majority of patients refuse to take medications due to adverse effects and/or stigmatization. […] Omega-3 PUFAs have been reported to be effective in the treatment of BDs. In a pioneer randomized-controlled trial, omega-3 PUFAs showed prophylactic effects in the 4-month course of BD, with longer periods of clinical remission as compared to placebo. […] This observation suggests that omega-3 PUFAs could prevent depression but not mania in patients with BD. […] Omega-3 PUFAs are well tolerated and accepted, and have been applied for many years as the secondary prevention in various chronic medical diseases and mental disorders. In this review, we found that the clinical evidence about omega-3 PUFAs preventive benefits on mood and anxiety disorders is supported by their regulatory effects on immunomodulation, anti-inflammation, signal transduction, neurotransmission and neuroprotection. Our current review calls for more prospective clinical trials in identified high-risk populations to justify the preventive application of omega-3 PUFAs in daily practice.

• #10 Folic acid supplementation for prevention of mood disorders in young people at familial risk: a randomised, double blind, placebo controlled trial – PubMed

  https://pubmed.ncbi.nlm.nih.gov/25010374/

  Folic acid supplementation for prevention of mood disorders in young people at familial risk: a randomised, double blind, placebo controlled trial […] Background: Clinical mood disorders often become clinically manifest in the later teenage years and early twenties and can be associated with a poor long-term prognosis. The primary prevention of these disorders would therefore have great public health value. Nutritional supplements are a feasible intervention for primary prevention and several epidemiological studies have indicated links between low folate status and depressive symptomatology in the general population. […] Method: A randomised, double blind, parallel group, placebo-controlled trial in which participants, aged 14-24 years, at increased familial risk of mood disorder, were randomised to folic acid (2.5 mg daily) or identical placebo liquid for a maximum of 36 months. Primary outcome data (the onset of a DSM-IV mood disorder) were collected from 112 participants; 56 per group.

• #11 Folic acid supplementation for prevention of mood disorders in young people at familial risk: a randomised, double blind, placebo controlled trial – PubMed

  https://pubmed.ncbi.nlm.nih.gov/25010374/

  Results: The incidence of mood disorder in the folic acid and placebo groups were 14.3% and 17.9% respectively, a non-significant difference. However, there was post-hoc evidence that folic acid delayed the time to onset of mood disorder in those participants who became unwell. […] Conclusions: Although long term folic acid supplementation was well tolerated, with high levels of adherence, there was no evidence that it reduced the incidence of mood disorder compared to those taking placebo.

• #12 Major depressive disorder: hypothesis, mechanism, prevention and treatment | Signal Transduction and Targeted Therapy

  https://www.nature.com/articles/s41392-024-01738-y

  Dietary adjustment is an effective, safe, and widely applicable method for preventing MDD, especially by inhibiting MDD-related pathological inflammation. Various nutrients can possess different anti-inflammatory properties; in contrast, there are many proinflammatory foods, such as those high in refined starch, sugar, and saturated fat and low in fiber and omega-3 fatty acids, which can promote the occurrence of inflammation to increase the risk of MDD. […] Increasing evidence suggests that physical exercise can prevent some mental disorders in addition to cardiovascular disease. This finding suggests that physical exercise may be able to prevent MDD. As reported in some studies, physical exercise can effectively prevent depression by affecting many molecular and cellular pathways; for instance, physical exercise can stimulate VEGF expression, leading to cellular level changes, such as stimulation of angiogenesis, increased delivery of neurotrophic factors and oxygen by the vascular system, an increase in the neurogenesis rate and induction of synaptogenesis.

• #12 Major depressive disorder: hypothesis, mechanism, prevention and treatment | Signal Transduction and Targeted Therapy

  https://www.nature.com/articles/s41392-024-01738-y

  MDD is a disease with a high prevalence worldwide, and preventing its occurrence and recurrence is crucial. Lifestyle medicine is an evolving medical specialty that aims to prevent chronic, noncommunicable diseases through lifestyle interventions. The goal of lifestyle medicine is to prevent the occurrence and recurrence of disease by improving sleep hygiene and diet, increasing physical exercise, avoiding sedentary behavior, increasing social support, and improving mood. In recent years, an increasing number of studies have demonstrated that the occurrence and recurrence of MDD can be prevented by means of lifestyle medicine; we summarize these reports in this section. […] Improving sleep is an important strategy to prevent the occurrence of depression. Insomnia is included in the diagnostic criteria for MDD. However, few studies have examined whether treating insomnia can prevent the exacerbation of depressive symptoms. Treating insomnia can prevent the worsening of depressive symptoms, and cognitive behavioral therapy for insomnia (CBT-I) is a recommended intervention for treating insomnia to improve sleep and mood.

• #12 Major depressive disorder: hypothesis, mechanism, prevention and treatment | Signal Transduction and Targeted Therapy

  https://www.nature.com/articles/s41392-024-01738-y

  Social support refers to the help provided by social relations and transactions. Social support may be obtained from a variety of individuals, including family members, friends, coworkers, and community members. Furthermore, a variety of factors, including the quantity and quality of support as well as subjectively perceived social support by individuals, impact the level of social support. It has been reported that MDD patients often lack social support, and receiving adequate social support can confer greater resistance to stress and prevent the occurrence and recurrence of MDD.

• #13 Self-management of mood and/or anxiety disorders through physical activity/exercise – HPCDP: Volume 37-5, May 2017 – Canada.ca

  https://www.canada.ca/en/public-health/services/reports-publications/health-promotion-chronic-disease-prevention-canada-research-policy-practice/vol-37-no-5-2017/self-management-mood-anxiety-disorders-physical-activity-exercise.html

  Physical activity/exercise is regarded as an important self-management strategy for individuals with mental illness. […] The most important factor associated with engaging in physical activity/exercise was to have received advice to do so by a physician or other health professional. […] It is essential that health professionals recommend physical activity/exercise to their patients, discuss barriers and support their engagement. […] While regular physical activity/exercise has been shown to improve depression and anxiety symptoms, approximately 50% of those diagnosed with these disorders in our study did not exercise regularly (i.e. at least once a week), highlighting an opportunity for improvement in the care and management of such individuals. […] The advice from a doctor or other health professional to participate in physical activity/exercise was the most important factor associated with being active at least once a week.

• #14 Self-management of mood and/or anxiety disorders through physical activity/exercise – HPCDP: Volume 37-5, May 2017 – Canada.ca

  https://www.canada.ca/en/public-health/services/reports-publications/health-promotion-chronic-disease-prevention-canada-research-policy-practice/vol-37-no-5-2017/self-management-mood-anxiety-disorders-physical-activity-exercise.html

  Therefore, receiving or not receiving advice, based on the point estimate of the OR, is more strongly associated with physical activity/exercise than education, age, province and type of disorder. […] Health practitioners play a critical role in recommending physical activity/exercise and supporting its engagement, particularly for those with a mood disorder and physical comorbidities.

• #15 How To Prevent Mood Disorders – Northwest Ohio Ketamine Clinic

  https://nwohioketamineclinic.com/how-to-prevent-mood-disorders/

  Sleep deprivation makes it hard to cope with even the most minor of stressors, leading to increased irritability, anger, and moodiness and essentially increasing the risk of developing a mood illness. […] Chronic stress is a major risk factor for mood disorders. […] Maintaining strong, supportive relationships with family and friends is fundamental to mental health and wellness. […] One of the most important steps in preventing mood disorders is recognizing when you need professional help. […] Just as regular physical check-ups are important for maintaining physical health, routine mental health check-ups can be crucial for preventing mood disorders. […] Taking proactive steps towards mental wellness, like regular exercise, a balanced diet, and maintaining a regular sleep schedule, are essential, and can be complemented by innovative treatments like ketamine therapy. […] Remember, seeking help is not a sign of weakness, but a testament to your strength and resilience.

• #16 Bipolar disorder – Symptoms and causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/bipolar-disorder/symptoms-causes/syc-20355955

  There’s no sure way to prevent bipolar disorder. But getting treated as soon as you notice a mental health disorder can help stop bipolar disorder or other mental health conditions from getting worse. […] If you’ve been diagnosed with bipolar disorder, here are some ways you can stop minor symptoms from becoming full-blown episodes of mania or depression: […] Pay attention to warning signs. Talking with your care team about symptoms early on can stop episodes from getting worse. You may have found a pattern to your bipolar episodes and what causes them. Call your healthcare professional or mental health professional if you feel you’re starting to have an episode of depression or mania. Ask your family members or friends to watch for warning signs. […] Get enough sleep. Sleep disruptions often cause bipolar instability.

• #17 Parents with mood disorders should know the risks for their children

  https://www.oatext.com/Parents-with-mood-disorders-should-know-the-risks-for-their-children.php

  If prodromal symptoms develop, a wealth of data support the utility of family focused therapy (FFT) or a similar therapy that deals with psychoeducation, enhancing family communication, and developing problem solving skills. […] This would represent secondary prevention or the attempt to deter development of more severe illness. […] When youngsters after a first hospitalization for mania are randomized to 2 years of comprehensive expert treatment compared to treatment as usual, there is a marked reduction in the rate of re-hospitalization over these 2 years and difference further grows in magnitude over the next 6 years. […] Taken together, these data emphasize the crucial importance of beginning careful, consistent, and comprehensive pharmacoprophylaxis after a first mania. […] A clinical trials network in practice settings would do much to help facilitate the more rapid accumulation of acute treatment data in easy-to-perform practical clinical trials, as well as those from all three types of prophylaxis studies.

• #18 Transmission and Prevention of Mood Disorders among Children of Affectively Ill Parents: A Review – Wellesley Centers for Women

  https://www.wcwonline.org/Publications-by-author/transmission-and-prevention-of-mood-disorders-among-children-of-affectively-ill-parents-a-review

  Transmission and Prevention of Mood Disorders among Children of Affectively Ill Parents: A Review […] Recent efforts in prevention research were discussed, gaps in the existing literature were noted, and directions for targeted research on children of depressed parents were highlighted. […] In addition, progress has been made in identifying risk mechanisms and moderators that underlie the transmission of disorder and in developing effective prevention programs. […] This review highlights directions for further research, including different areas affected by parental depression in parents and children, and in understanding the underlying mechanisms involved in the intergenerational transmission of depression, so that preventive and treatment efforts can be tailored effectively.

• #19

  https://www.who.int/news-room/fact-sheets/detail/depression

  Depression results from a complex interaction of social, psychological, and biological factors. People who have gone through adverse life events (unemployment, bereavement, traumatic events) are more likely to develop depression. […] Prevention programmes have been shown to reduce depression. Effective community approaches to prevent depression include school-based programmes to enhance a pattern of positive coping in children and adolescents. Interventions for parents of children with behavioural problems may reduce parental depressive symptoms and improve outcomes for their children. Exercise programmes for older persons can also be effective in depression prevention.

• #20 Translational Research in Late-Life Mood Disorders: Implications for Future Intervention and Prevention Research | Neuropsychopharmacology

  https://www.nature.com/articles/1301333

  Clinical and epidemiological studies have consistently observed the heterogeneous symptomatology and course of geriatric depression. […] Understanding the nature of geriatric depression requires the application of translational research and interdisciplinary research approaches. […] Future directions for integrative research were identified. Understanding the nature of geriatric depression requires the application of translational research and interdisciplinary research approaches. […] Clinical and epidemiological studies have identified some of the psychosocial and medical factors associated with depression, vulnerability, and prevention strategies have been evaluated in some instances (eg, bereavement, post-stroke depression, and interferon induced depression; Shear et al, 2005; Narushima et al, 2002; Whyte et al, 2004, Musselman et al, 2001).

• #21 Translational Research in Late-Life Mood Disorders: Implications for Future Intervention and Prevention Research | Neuropsychopharmacology

  https://www.nature.com/articles/1301333

  Although the choice of therapeutic agents for these prevention studies have focused on standard pharmacological and psychosocial interventions, emerging neurobiological data will potentially inform the development of novel therapeutic strategies. […] The application of an interdisciplinary research approach is critical to understanding of such issues in geriatric depression as treatment response variability, the increased morbidity, and mortality associated with depression in late-life and the role of depression as a possible risk factor for dementia. […] Future mechanistic research in geriatric depression is influenced by methodological developments in genetics, affective, and cognitive neuroscience and neuroimaging, by the ability to integrate information across different research modalities and by using the information obtained to generate new hypotheses and therapeutic strategies.

• #22 Translational Research in Late-Life Mood Disorders: Implications for Future Intervention and Prevention Research | Neuropsychopharmacology

  https://www.nature.com/articles/1301333

  The integration of genetic and neuroimaging measures may identify neurochemical subtypes of depression that may be associated with different speeds and rates of treatment response to different classes of antidepressant medications or to interventions, such as ECT, deep brain stimulation or transcranial magnetic stimulation. […] The important area of post-mortem studies include (1) the further characterization of the pathophysiology of geriatric depression to inform the design of genetic, neuroimaging and neuropsychological studies; (2) the correlation of post-mortem data with cognitive and neuroimaging findings to understand the substrates of persistent mood and cognitive symptoms such as anhedonia and executive dysfunction; and (3) the correlation of postmortem and imaging findings to understand the underlying pathophysiology of volumetric loss, white matter hyperintensities and neurochemical imaging findings.

• #23 Prevention of mood disorder after stroke: a randomised controlled trial of problem solving therapy versus volunteer support | BMC Neurology | Full Text

  https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-019-1349-8

  Mood disorder after stroke is common but drug and psychosocial treatments have been assessed with disappointing results. Preventing mood disorder from developing in the first place could be a better approach and might reduce the need for pharmacotherapy in this predominantly older patient group. […] The results are encouraging and suggest it is possible to prevent mood disorder in stroke patients using a psychological intervention. […] Nonetheless, psychosocial interventions may have a role in preventing mood disorder after stroke, as recent reviews have concluded, and there is still a need for more trials in this area. […] Our trial randomised 150 patients to receive a short-term psychological treatment and demonstrated that problem-solving therapy has potential value for the reduction or prevention of emotional disorders after stroke.

• #24 Lithium in the prevention of suicide in mood disorders: updated systematic review and meta-analysis | The BMJ

  https://www.bmj.com/content/346/bmj.f3646

  Objective To assess whether lithium has a specific preventive effect for suicide and self harm in people with unipolar and bipolar mood disorders. […] Lithium is an effective treatment for reducing the risk of suicide in people with mood disorders. […] Lithium may exert its antisuicidal effects by reducing relapse of mood disorder, but additional mechanisms should also be considered because there is some evidence that lithium decreases aggression and possibly impulsivity, which might be another mechanism mediating the antisuicidal effect. […] Lithium was associated with a reduced risk of suicide when compared with placebo, and also a reduced risk of deliberate self harm compared with carbamazepine. […] A new finding is that lithium reduces the risk of suicide and total deaths in people with both unipolar and bipolar depressive disorder.

• #25 Lithium in the prevention of suicide in mood disorders: updated systematic review and meta-analysis | The BMJ

  https://www.bmj.com/content/346/bmj.f3646

  Lithium seems to reduce the risk of death and suicide by more than 60% compared with placebo. […] The reduction in the risk in all cause mortality mainly reflects a reduction in risk of suicide, because most of the deaths in the trials were from suicides. […] The comparability in the relative risk reduction of both suicide and all cause mortality also indicates that there was no increase in fatal events with lithium. […] Lithium is an effective long term treatment for both bipolar and unipolar mood disorders. […] The antisuicidal effect estimated here is larger than the effect on mood episodes, raising the possibility of a specific effect. […] Understanding the mechanism by which lithium acts to decrease suicidal behaviour could lead to a better understanding of the neurobiology of suicide. […] The evidence that lithium reduces the risk of suicide and possibly deliberate self harm in people with bipolar disorder and recurrent unipolar depression indicates that lithium should continue to have an important clinical role.

• #26 Lithium in the episode and suicide prophylaxis and in augmenting strategies in patients with unipolar depression | International Journal of Bipolar Disorders | Full Text

  https://journalbipolardisorders.springeropen.com/articles/10.1186/s40345-017-0080-x

  According to many studies mostly dating back to the 1970/1980s, lithium is efficacious in the prophylaxis of unipolar depression particularly depression with melancholia and delusional depression and showing a clearly episodic course. […] We conclude that lithium is an effective prophylactic treatment for carefully selected patients with unipolar depression and is safe when prescribed in recommended doses/plasma lithium levels and with regular, careful monitoring. […] We propose that lithium prophylaxis can be indicated in patients with unipolar depression and that the occurrence of 2 episodes of depression within 5 years is a practical criterion for starting lithium prophylaxis particularly in severe depression with psychotic features and high suicidal risk. […] Lithium is an effective prophylactic treatment in selected patients with unipolar depression in its classic form.

• #27 Lithium in the episode and suicide prophylaxis and in augmenting strategies in patients with unipolar depression | International Journal of Bipolar Disorders | Full Text

  https://journalbipolardisorders.springeropen.com/articles/10.1186/s40345-017-0080-x

  In our view, lithium prophylaxis is indicated in severe, clearly episodic unipolar depression that failed to respond to antidepressant medication. […] We propose that in unipolar depression, the occurrence of 2 episodes of depression within 5 years is a practical criterion for starting lithium prophylaxis particularly in severe depression with psychotic features high suicidal risk and particularly in such patients in whom a bipolar background can be suspected. […] Lithium maintenance therapy is strongly recommended for the long-term management of selected patients with unipolar depression since there is strong evidence for its episode-preventing efficacy and unique anti-suicidal effects.

• #28 Mood Disorders | Ohio State Medical Center

  https://wexnermedical.osu.edu/mental-behavioral/mood-disorders

  When a mood disorder affects the way you interact with others, how you feel about yourself and your ability to work or go to school, it can be greatly debilitating. […] We’re working diligently every day to research and develop therapies to prevent mood disorders from returning or even happening in the first place. […] Prevention methods, like mindfulness-based cognitive therapy (MBCT) MBCT is group-based intervention that was designed to facilitate recovery from depression and prevent future depressive relapses. […] We focus on keeping you well. As difficult as it can be to treat someone with a mood disorder, it can be even more challenging to offer sustained recovery and prevent relapse.

• #29 Suicide prevention and mood disorders: Self-exclusion agreements for firearms as a suicide prevention strategy

  https://repository.law.umich.edu/articles/2403/

  Suicide involves a complex set of behaviors and emotions that lead up to actions that may be based on planning and forethought or the result of impulse. While there are a host of antecedent circumstances the presence of a mood disorder, primarily depression, is the most common factor in suicide. […] While management of depression is recognized as important prevention strategy in depression, the means by which suicide occurs must be a critical element of prevention. Policies that lower access to the means for suicide will decrease the fatality. […] A declaration of formal self-exclusion for access to firearms (guns and ammunition) offers the individual at greater risk for suicide to place themselves on an official list that would prevent them from purchasing lethal weapons. A person with depression, when well, might wish to enroll voluntarily to prevent themselves, when ill, from procuring a weapon to harm themselves or others. This recognizes the autonomy of the person and protects both the individual, the family, and society.

• #30 Web-based interventions for prevention and treatment of perinatal mood disorders: A systematic review

  https://www.healthevidence.org/view-article.aspx?a=29400

  Perinatal depression is strikingly common with a prevalence of 10-15 %. […] E-health, providing healthcare via the Internet is an accessible and effective solution for the treatment of depression in the general population. […] We aimed to conduct a systematic review of web-based interventions for the prevention and treatment of mood disorders in the perinatal period, defined as the start of pregnancy to 1 year post-partum. […] All reported an improvement in maternal mood following intervention. […] Preliminary data suggests web-based therapies for perinatal depression delivered in the post-partum period may play a role in improving maternal mood but more studies are needed, particularly with interventions delivered antenatally. Further research is needed to address the limitations of the existing evidence base.

• #31 What is the place of universal, selective, and indicated prevention strategies for depression and other mood disorders? | Research Directions: Depression | Cambridge Core

  https://resolve.cambridge.org/core/journals/research-directions-depression/article/what-is-the-place-of-universal-selective-and-indicated-prevention-strategies-for-depression-and-other-mood-disorders/5275BDD4B75778AD5A7A4B63A5489E40

  Over the last two decades, a great deal more enthusiasm has been expressed for preventive approaches despite the relative lack of evidence for large impacts from many current approaches. […] Accumulating evidence also indicates a more positive view of the potential impacts of selective (i.e., reduction of known risk factors) and indicated (focusing on those with symptoms, but sub-threshold for disorders) prevention strategies (Cuijpers et al., 2021). […] With the advent of new methods for broad dissemination of such interventions (largely via digital technologies), and new targets (such as sleep-wake cycle disruptions), the potential for indicated prevention at scale is a real possibility. […] While strong evidence exists for indicated prevention, and growing evidence for selective prevention, it is also important to differentiate studies that clearly focus on prevention of new onsets of depression (through critical longitudinal designs) from those that simply report reductions in depressive symptoms in those individuals who were initially symptomatic (Cuijpers, 2022).

• #32

  https://link.springer.com/article/10.1007/s40473-020-00203-8

  A considerable portion of bipolar patients do not respond well to available therapeutic strategies. Therefore, early identification of BD and its possible prevention are of high interest. […] Current research findings do not support the implementation of therapeutic interventions aiming at the prevention of BD. The therapeutic approach for symptomatic non-bipolar individuals at high genetic risk for BD is of high interest from a clinical and research standpoint. […] This paper provides a comprehensive review on the current status of early interventions in bipolar disorder. […] This paper describes a risk predictor for the development of BD I or II among individuals with BP Not-Otherwise-Specified. […] Folic acid supplementation for prevention of mood disorders in young people at familial risk: a randomised, double blind, placebo controlled trial. […] Early intervention for symptomatic youth at risk for bipolar disorder: a randomized trial of family-focused therapy.

• #33 Use of Neuroimaging Techniques for the Prevention, Assessment, and Treatment of Mood Disorders | Frontiers Research Topic

  https://www.frontiersin.org/research-topics/31384/use-of-neuroimaging-techniques-for-the-prevention-assessment-and-treatment-of-mood-disorders/magazine

  A significant majority of the suicide-related deaths occur in patients with major psychiatric disorders, particularly bipolar disorder (BD), major depressive disorder (MDD), and treatment-resistant depression (TRD). […] Those data alone emphasise the need for correct prevention, assessment, and treatment of such conditions. […] Neuroimaging technology can provide useful solutions towards the identification of biomarkers for the prevention, assessment, and treatment of mood disorders. […] Ultimately, this research would lead to the development of more effective prevention and early prophylactic strategies, and novel treatments. […] Areas covered by this section include but are not limited to the following: Mood disorders prevention

• #34 Mood Disorders | Child Crime Prevention & Safety Center

  https://childsafety.losangelescriminallawyer.pro/mood-disorders.html

  Many common mood disorders found in juveniles often include bipolar disorder, major depression, persistent depressive disorder, disruptive mood dysregulation disorder, and substance-induced mood disorder. […] When parents or guardians suspect that their child may be exhibiting symptoms of mood disorders it is critical that a mental health professional is sought out immediately to properly diagnose the child and begin treatment to address any potential disorders that the child may have. […] It is highly encouraged to address these issues as soon as they arise.

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