Materiały źródłowe

• #1 Non-Melanoma Skin Cancer: Statistical Associations between Clinical Parameters

  https://pmc.ncbi.nlm.nih.gov/articles/PMC9289586/

  Non-melanoma skin cancer (NMSC) represent an important health problem in medical practice. This is the most frequent type of cancer and its incidence is constantly increasing. Basal cell carcinoma and squamous cell carcinoma constitute the majority of NMSC, respectively 70% and 25% of total cases. The present retrospective study was conducted over a one-year period and included 439 cases of NMSC, of which 336 BCC and 103 SCC. We analyzed a series of clinical parameters: gender, age, tumor size and tumor topography. The statistical analysis of the investigated parameters indicated gender-age associations for BCC, and topography-gender, as well as topography-age for SCC. […] Non-melanoma skin cancers (NMSCs) represent an important health problem in medical practice, being the most frequent types of cancer. Their incidence is constantly increasing, accounting for 90% of all malignant skin tumors, and studies suggest that this trend will continue until at least the year 2040. Between 2007-2017, the incidence of NMSCs increased by 33%, reaching 7.7 million cases worldwide. In the last decade, in Europe, the incidence of BCC has increased annually by 5%, and some studies on SCC show that the incidence is rising and tends to approach that of BCC.

• #2 The incidence and clinical analysis of non-melanoma skin cancer | Scientific Reports

  https://www.nature.com/articles/s41598-021-83502-8

  Non-melanoma skin cancers (NMSCs) are the most common malignancies diagnosed in Caucasian populations. Basal cell carcinoma (BCC) is the most frequent skin cancer, followed by squamous cell carcinoma (SCC). Unfortunately, most European cancer registries do not record individual types of NMSC. […] To evaluate the incidence of primary BCCs and SCCs regarding age, sex, tumour site and tumour subtype to determine trends in epidemiology of both cancers. […] Non-melanoma skin cancers (NMSCs) are the most common human malignancies, with steadily rising incidence. The term NMSC refers to all non-melanoma malignant neoplasms affecting the skin. The main types of NMSC, basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), account for about 99% of all NMSCs. […] Although NMSC are 1820 times more frequent than cutaneous melanoma, there is little epidemiological data for those tumour types.

• #3 Non-Melanoma Skin Cancer: Statistical Associations between Clinical Parameters

  https://pmc.ncbi.nlm.nih.gov/articles/PMC9289586/

  According to the latest data, 3.6 million cases of BCC and 1.8 million cases of SCC are diagnosed annually in the United States. The incidence increases with age, and also multiplicity of SCC has been correlated with age. The prevalence values revealed significant increase during the last 20 years, 35% for BCC and 133% for SCC. Most NMSCs have a good prognosis and a low metastatic rate. […] Although for NMSC the impact on mortality is low, globally it causes 5,400 deaths per month, most of which are attributed to SCC. The United States reports 15,000 deaths annually from SCC. Survival is as low as 10-20% for metastatic SCC, this type being responsible for 75% of deaths caused by NMSC. […] The aim of this study was to assess the epidemiological development trends of BCC and SCC, and to analyze the associations between representative clinical parameters.

• #4 Non-Melanoma Skin Cancer: Statistical Associations between Clinical Parameters

  https://pmc.ncbi.nlm.nih.gov/articles/PMC9289586/

  Non-melanoma skin cancer (NMSC) represent an important health problem in medical practice. This is the most frequent type of cancer and its incidence is constantly increasing. Basal cell carcinoma and squamous cell carcinoma constitute the majority of NMSC, respectively 70% and 25% of total cases. The present retrospective study was conducted over a one-year period and included 439 cases of NMSC, of which 336 BCC and 103 SCC. We analyzed a series of clinical parameters: gender, age, tumor size and tumor topography. The statistical analysis of the investigated parameters indicated gender-age associations for BCC, and topography-gender, as well as topography-age for SCC. […] Non-melanoma skin cancers (NMSCs) represent an important health problem in medical practice, being the most frequent types of cancer. Their incidence is constantly increasing, accounting for 90% of all malignant skin tumors, and studies suggest that this trend will continue until at least the year 2040. Between 2007-2017, the incidence of NMSCs increased by 33%, reaching 7.7 million cases worldwide. In the last decade, in Europe, the incidence of BCC has increased annually by 5%, and some studies on SCC show that the incidence is rising and tends to approach that of BCC.

• #5 Global, regional, and national trends in the burden of melanoma and non-melanoma skin cancer: insights from the global burden of disease study 1990–2021 | Scientific Reports

  https://www.nature.com/articles/s41598-025-90485-3

  This study examines global, regional, and national trends in melanoma and non-melanoma skin cancer (NMSC) burden from 1990 to 2021, their socioeconomic associations, and projects future trends. […] The global burden of skin cancers has shown significant growth over the study period, with the age-standardized incidence rate (ASIR) rising globally (Estimated Annual Percentage Change, EAPC=1.94%) from 1990 to 2021. […] In 2021, the most recent year covered, the global incidence of skin cancers was 6.64 million cases, with an ASIR of 77.66 per 100,000 and a disability-adjusted life years (DALYs) burden of 2.89 million cases. […] Skin cancer incidence is rising globally, driven by demographic changes, increased UV exposure, and improved detection. […] The burden of melanoma has decreased, which may be related to advances in treatment.

• #6 Changing trends in the disease burden of non-melanoma skin cancer globally from 1990 to 2019 and its predicted level in 25 years | BMC Cancer | Full Text

  https://bmccancer.biomedcentral.com/articles/10.1186/s12885-022-09940-3

  The disease burden of non-melanoma skin cancer (NMSC) has become a significant public health threat. […] The disease burden was significantly higher in males than in females in 2019. […] The better the socio-economic development, the heavier the disease burden of NMSC. […] The age-standardized incidence rate (ASIR) of NMSC increased from 54.08/100,000 in 1990 to 79.10/100,000 in 2019, with an estimated annual percentage change (EAPC) of 1.78. […] Our predictions suggested that the number of new cases, deaths, and DALYs attributable to NMSC would increase by at least 1.5 times from 2020 to 2044. […] The disease burden attributable to NMSC will continue to increase or remain stable at high levels. […] This is the first systematic assessment and prediction of the disease burden of non-melanoma skin cancer worldwide. […] The disease burden will continue to increase or remain relatively stable at high levels in the future.

• #7 Global, regional, and national trends in the burden of melanoma and non-melanoma skin cancer: insights from the global burden of disease study 1990–2021 | Scientific Reports

  https://www.nature.com/articles/s41598-025-90485-3

  From 1990 to 2021, the global ASIR significantly increased for all three cancers, with EAPC of 0.65 for malignant melanoma, 2.01 for BCC, and 2.06 for SCC. […] The projected rise in global ASIR, particularly for BCC and SCC, underscores the impact of population aging. […] The ARIMA model predicts a significant increase in ASIR by 2030, driven primarily by aging populations in high- and middle-income regions. […] The findings highlight the complex interplay of demographic, environmental, and healthcare factors driving these trends.

• #8 Non-Melanoma Skin Cancer: Statistical Associations between Clinical Parameters

  https://pmc.ncbi.nlm.nih.gov/articles/PMC9289586/

  Non-melanoma skin cancer (NMSC) represent an important health problem in medical practice. This is the most frequent type of cancer and its incidence is constantly increasing. Basal cell carcinoma and squamous cell carcinoma constitute the majority of NMSC, respectively 70% and 25% of total cases. The present retrospective study was conducted over a one-year period and included 439 cases of NMSC, of which 336 BCC and 103 SCC. We analyzed a series of clinical parameters: gender, age, tumor size and tumor topography. The statistical analysis of the investigated parameters indicated gender-age associations for BCC, and topography-gender, as well as topography-age for SCC. […] Non-melanoma skin cancers (NMSCs) represent an important health problem in medical practice, being the most frequent types of cancer. Their incidence is constantly increasing, accounting for 90% of all malignant skin tumors, and studies suggest that this trend will continue until at least the year 2040. Between 2007-2017, the incidence of NMSCs increased by 33%, reaching 7.7 million cases worldwide. In the last decade, in Europe, the incidence of BCC has increased annually by 5%, and some studies on SCC show that the incidence is rising and tends to approach that of BCC.

• #9 Epidemiology of Skin Cancer in 2024 | IntechOpen

  https://www.intechopen.com/chapters/1195964

  The incidence of skin cancer has risen globally in recent years, with 2024 marking a critical point in understanding its epidemiology and burden on public health. […] This chapter provides a comprehensive overview of the current epidemiology of skin cancer, focusing on both melanoma and non-melanoma skin cancers (NMSC). […] Understanding the global epidemiology of NMSC is crucial for public health efforts aimed at prevention and management. […] Non-melanoma skin cancer (NMSC) refers to a group of cancers that originate from the skins epidermal cells, with the two most common types being basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). NMSC is the most frequently diagnosed cancer globally, with an increasing incidence in both developed and developing nations. […] In North America, particularly the United States and Canada, NMSC incidence is notably high. The United States alone accounts for approximately 5.4 million cases of NMSC annually.

• #10 Epidemiology of Skin Cancer in 2024 | IntechOpen

  https://www.intechopen.com/chapters/1195964

  NMSC rates have increased significantly over the last several decades, with studies showing that the incidence of BCC has risen by 145% and SCC by 263% between the 1970s and the 2010s. […] In Europe, NMSC is also one of the most commonly diagnosed cancers, though incidence varies by region. […] The European Academy of Dermatology and Venereology (EADV) has reported an annual increase of 38% in NMSC cases over recent decades. […] Australia and New Zealand have the highest reported rates of NMSC in the world, with Australia recording an incidence of over 1000 cases per 100,000 people per year. […] In Asia, the incidence of NMSC is generally lower than in Western countries, though it is on the rise in some regions. […] NMSC incidence in Africa is lower than in regions with predominantly lighter-skinned populations, although the data are limited.

• #11 Epidemiology of Skin Cancer in 2024 | IntechOpen

  https://www.intechopen.com/chapters/1195964

  The incidence of skin cancer has risen globally in recent years, with 2024 marking a critical point in understanding its epidemiology and burden on public health. […] This chapter provides a comprehensive overview of the current epidemiology of skin cancer, focusing on both melanoma and non-melanoma skin cancers (NMSC). […] Understanding the global epidemiology of NMSC is crucial for public health efforts aimed at prevention and management. […] Non-melanoma skin cancer (NMSC) refers to a group of cancers that originate from the skins epidermal cells, with the two most common types being basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). NMSC is the most frequently diagnosed cancer globally, with an increasing incidence in both developed and developing nations. […] In North America, particularly the United States and Canada, NMSC incidence is notably high. The United States alone accounts for approximately 5.4 million cases of NMSC annually.

• #12 Epidemiology of Skin Cancer in 2024 | IntechOpen

  https://www.intechopen.com/chapters/1195964

  NMSC rates have increased significantly over the last several decades, with studies showing that the incidence of BCC has risen by 145% and SCC by 263% between the 1970s and the 2010s. […] In Europe, NMSC is also one of the most commonly diagnosed cancers, though incidence varies by region. […] The European Academy of Dermatology and Venereology (EADV) has reported an annual increase of 38% in NMSC cases over recent decades. […] Australia and New Zealand have the highest reported rates of NMSC in the world, with Australia recording an incidence of over 1000 cases per 100,000 people per year. […] In Asia, the incidence of NMSC is generally lower than in Western countries, though it is on the rise in some regions. […] NMSC incidence in Africa is lower than in regions with predominantly lighter-skinned populations, although the data are limited.

• #13 Epidemiology of Skin Cancer in 2024 | IntechOpen

  https://www.intechopen.com/chapters/1195964

  NMSC rates have increased significantly over the last several decades, with studies showing that the incidence of BCC has risen by 145% and SCC by 263% between the 1970s and the 2010s. […] In Europe, NMSC is also one of the most commonly diagnosed cancers, though incidence varies by region. […] The European Academy of Dermatology and Venereology (EADV) has reported an annual increase of 38% in NMSC cases over recent decades. […] Australia and New Zealand have the highest reported rates of NMSC in the world, with Australia recording an incidence of over 1000 cases per 100,000 people per year. […] In Asia, the incidence of NMSC is generally lower than in Western countries, though it is on the rise in some regions. […] NMSC incidence in Africa is lower than in regions with predominantly lighter-skinned populations, although the data are limited.

• #14 Epidemiology of Skin Cancer in 2024 | IntechOpen

  https://www.intechopen.com/chapters/1195964

  NMSC rates have increased significantly over the last several decades, with studies showing that the incidence of BCC has risen by 145% and SCC by 263% between the 1970s and the 2010s. […] In Europe, NMSC is also one of the most commonly diagnosed cancers, though incidence varies by region. […] The European Academy of Dermatology and Venereology (EADV) has reported an annual increase of 38% in NMSC cases over recent decades. […] Australia and New Zealand have the highest reported rates of NMSC in the world, with Australia recording an incidence of over 1000 cases per 100,000 people per year. […] In Asia, the incidence of NMSC is generally lower than in Western countries, though it is on the rise in some regions. […] NMSC incidence in Africa is lower than in regions with predominantly lighter-skinned populations, although the data are limited.

• #15 Non-melanoma skin cancer statistics | Cancer Research UK

  https://www.cancerresearchuk.org/health-professional/cancer-statistics/statistics-by-cancer-type/non-melanoma-skin-cancer

  There are around 156,000 new non-melanoma skin cancer cases in the UK every year, that’s nearly 430 every day (2016-2018). […] In females in the UK, non-melanoma skin cancer accounted for around 67,500 new cancer cases every year (2016-2018). […] In males in the UK, non-melanoma skin cancer accounted for around 88,500 new cancer cases every year in 2016-2018. […] Incidence rates for non-melanoma skin cancer in the UK are highest in people aged 90+ (2016-2018). […] Each year almost half (48%) of all new non-melanoma skin cancer cases in the UK are diagnosed in people aged 75 and over (2016-2018). […] Since the early 1990s, non-melanoma skin cancer incidence rates have increased by more than two-and-a-half times (169%) in the UK. Rates in females have increased by more than two-and-a-half times (163%), and rates in males have increased by more than two-and-a-half times (163%) (2016-2018).

• #16 Non-melanoma skin cancer statistics | Cancer Research UK

  https://www.cancerresearchuk.org/health-professional/cancer-statistics/statistics-by-cancer-type/non-melanoma-skin-cancer

  There are around 156,000 new non-melanoma skin cancer cases in the UK every year, that’s nearly 430 every day (2016-2018). […] In females in the UK, non-melanoma skin cancer accounted for around 67,500 new cancer cases every year (2016-2018). […] In males in the UK, non-melanoma skin cancer accounted for around 88,500 new cancer cases every year in 2016-2018. […] Incidence rates for non-melanoma skin cancer in the UK are highest in people aged 90+ (2016-2018). […] Each year almost half (48%) of all new non-melanoma skin cancer cases in the UK are diagnosed in people aged 75 and over (2016-2018). […] Since the early 1990s, non-melanoma skin cancer incidence rates have increased by more than two-and-a-half times (169%) in the UK. Rates in females have increased by more than two-and-a-half times (163%), and rates in males have increased by more than two-and-a-half times (163%) (2016-2018).

• #17 Incidence of Non-melanoma Skin Cancers Steadily Increasing

  https://www.pharmacytimes.com/view/incidence-of-non-melanoma-skin-cancers-steadily-increasing

  New diagnoses of squamous cell carcinoma increased 263% and basal cell carcinoma increased 145%. […] In recent years, the number of new skin cancer diagnoses has risen. […] The investigators compared the 2000-2010 period to 1976-1984 and 1985-1992. The results of the study found that squamous cell carcinoma diagnoses increased 263% during 2000 and 2010, and basal cell carcinoma diagnoses increased 145%. […] Women aged 30 to 49 years had the greatest increase in basal cell carcinoma, whereas, women aged 40 to 59 years and 70 to 79 years experienced the greatest increase in squamous cell carcinomas. […] Squamous cell carcinoma diagnoses among men increased between the 1976 and 1984 period and the 1985 to 1992 period. However, there was a slight dip between 2000 and 2010. […] Men over 29 years had similar increases in basal cell carcinoma diagnoses in the 2000 to 2010 period compared with the 2 earlier periods.

• #18 Changing trends in the disease burden of non-melanoma skin cancer globally from 1990 to 2019 and its predicted level in 25 years | BMC Cancer | Full Text

  https://bmccancer.biomedcentral.com/articles/10.1186/s12885-022-09940-3

  The disease burden of non-melanoma skin cancer (NMSC) has become a significant public health threat. […] The disease burden was significantly higher in males than in females in 2019. […] The better the socio-economic development, the heavier the disease burden of NMSC. […] The age-standardized incidence rate (ASIR) of NMSC increased from 54.08/100,000 in 1990 to 79.10/100,000 in 2019, with an estimated annual percentage change (EAPC) of 1.78. […] Our predictions suggested that the number of new cases, deaths, and DALYs attributable to NMSC would increase by at least 1.5 times from 2020 to 2044. […] The disease burden attributable to NMSC will continue to increase or remain stable at high levels. […] This is the first systematic assessment and prediction of the disease burden of non-melanoma skin cancer worldwide. […] The disease burden will continue to increase or remain relatively stable at high levels in the future.

• #19 Non-melanoma skin cancer statistics | Cancer Research UK

  https://www.cancerresearchuk.org/health-professional/cancer-statistics/statistics-by-cancer-type/non-melanoma-skin-cancer

  Over the last decade, non-melanoma skin cancer incidence rates have increased by more than two-fifths (42%) in the UK. Rates in females have increased by more than two-fifths (42%), and rates in males have increased by two-fifths (40%) (2016-2018). […] Non-melanoma skin cancer incidence rates are projected to rise by 14% in the UK between 2023-2025 and 2038-2040. […] There could be more than 262,000 new cases of non-melanoma skin cancer every year in the UK by 2038-2040, projections suggest. […] Non-melanoma skin cancer mortality rates are projected to fall by 9% in the UK between 2023-2025 and 2038-2040. […] There could be around around 710 deaths of non-melanoma skin cancer every year in the UK by 2038-2040, projections suggest.

• #20 Non-melanoma skin cancer incidence statistics | Cancer Research UK

  https://www.cancerresearchuk.org/health-professional/cancer-statistics/statistics-by-cancer-type/non-melanoma-skin-cancer/incidence

  The number of new non-melanoma skin cancer cases on average each year in the UK is projected to rise from more than 188,000 cases in 2023-2025 to more than 262,000 cases in 2038-2040. […] Non-melanoma skin cancer incidence rates are projected to rise by 14% in the UK between 2023-2025 and 2038-2040, to 310 cases per 100,000 people on average each year by 2038-2040. […] Non-melanoma skin cancer incidence rates (European age-standardised (AS) rates) in England in females are 40% lower in the most deprived quintile compared with the least, and in males are 42% lower in the most deprived quintile compared with the least (2013-2017). […] It is estimated that there are around 25,000 fewer cases of non-melanoma skin cancer each year in England than there would be if every deprivation quintile had the same age-specific crude incidence rates as the least deprived quintile.

• #21 Global, regional, and national trends in the burden of melanoma and non-melanoma skin cancer: insights from the global burden of disease study 1990–2021 | Scientific Reports

  https://www.nature.com/articles/s41598-025-90485-3

  From 1990 to 2021, the global ASIR significantly increased for all three cancers, with EAPC of 0.65 for malignant melanoma, 2.01 for BCC, and 2.06 for SCC. […] The projected rise in global ASIR, particularly for BCC and SCC, underscores the impact of population aging. […] The ARIMA model predicts a significant increase in ASIR by 2030, driven primarily by aging populations in high- and middle-income regions. […] The findings highlight the complex interplay of demographic, environmental, and healthcare factors driving these trends.

• #22 Advanced and Metastatic Non-Melanoma Skin Cancer: Epidemiology, Risk Factors, Clinical Features, and Treatment Options

  https://www.mdpi.com/2227-9059/12/7/1448

  Non-melanoma skin cancers (NMSC) form the majority of skin cancers, with basal cell carcinoma (BCC) being the most common and cutaneous squamous cell carcinoma (cSCC) being second. Prolonged ultraviolet (UV) exposure, aging, male gender, and immunosuppression represent most of the causes of this category of diseases. […] The incidence of NMSC has steadily increased by around 3% a year for BCC. […] Overall, NMSCs occur in around 2 million people globally each year. Their prevalence varies based on the population discussed. BCC is much higher in white populations (75–80% of skin cancers) when compared to darker skin tones (20–30%). […] While rarely fatal, BCC is potentially disfiguring and harmful to local tissues, making its increase in incidence (3% yearly) problematic. […] The market size of the skin cancer treatment market was valued at USD 7.2 billion in 2021 and is estimated to double by 2031 to around USD 14.5 billion.

• #23 Skin cancer

  https://www.aad.org/media/stats-skin-cancer

  Research indicates that men with melanoma generally have lower survival rates than women with melanoma. (6,8,24) […] Overall melanoma death rates drastically declined from 2014 through 2022 by nearly 4%. (6) […] Excess exposure to UV radiation from sunlight or use of indoor tanning also increases risk for all skin cancer types, as does a personal history of the disease. (6) […] The majority of melanoma cases are attributable to UV exposure. (25-28) […] Risk factors for all types of skin cancer include skin that burns easily; blonde or red hair; a history of excessive sun exposure, including sunburns; tanning bed use; a weakened immune system; and a history of skin cancer. (6) […] People with more than 50 moles, atypical moles or large moles are at an increased risk of developing melanoma, as are sun-sensitive individuals (e.g., those who sunburn easily, or have natural blonde or red hair), individuals who have received a blood or marrow transplant, individuals who were diagnosed with cancer as a child, and those with a personal or family history of melanoma. (6,37-39)

• #24 Skin cancer

  https://www.aad.org/media/stats-skin-cancer

  Research indicates that men with melanoma generally have lower survival rates than women with melanoma. (6,8,24) […] Overall melanoma death rates drastically declined from 2014 through 2022 by nearly 4%. (6) […] Excess exposure to UV radiation from sunlight or use of indoor tanning also increases risk for all skin cancer types, as does a personal history of the disease. (6) […] The majority of melanoma cases are attributable to UV exposure. (25-28) […] Risk factors for all types of skin cancer include skin that burns easily; blonde or red hair; a history of excessive sun exposure, including sunburns; tanning bed use; a weakened immune system; and a history of skin cancer. (6) […] People with more than 50 moles, atypical moles or large moles are at an increased risk of developing melanoma, as are sun-sensitive individuals (e.g., those who sunburn easily, or have natural blonde or red hair), individuals who have received a blood or marrow transplant, individuals who were diagnosed with cancer as a child, and those with a personal or family history of melanoma. (6,37-39)

• #25 Sun-related behaviors among individuals previously diagnosed with non-melanoma skin cancer – Indian Journal of Dermatology, Venereology and Leprology

  https://ijdvl.com/sun-related-behaviors-among-individuals-previously-diagnosed-with-non-melanoma-skin-cancer/

  Compared to the general population, the risk of developing non-melanoma skin cancer is considerably higher among individuals with a previous history of this condition. […] Skin cancer survivors must be educated about their increased risk of future skin cancers. […] The diagnosis of non-melanoma skin cancer portends a significantly increased risk of developing new skin cancers of all kinds including malignant melanoma. […] Approximately, 90% of all non-melanoma skin cancers are caused by sunlight exposure. […] The findings, although limited, strongly suggest that intervention programs for non-melanoma skin cancer survivors should focus on increasing knowledge and the perceived risk of skin cancer. […] Health care professionals should be encouraged to provide education to patients regarding skin cancer risk and primary prevention strategies (e.g., wearing protective clothing, using sunscreen, and staying in shade). […] Further studies are required with the non-melanoma skin cancer population to draw firm conclusions regarding the associations that may correlate with sun protection behaviors.

• #26 Non-Melanoma Skin Cancer: Statistical Associations between Clinical Parameters

  https://pmc.ncbi.nlm.nih.gov/articles/PMC9289586/

  Known as the most common type of cancer worldwide, NMSC continues to show an increasing incidence rate as a result of the accumulation of multiple risk factors. Among those, exposure to UV radiation is the most important. Studies have shown the link between the development of BCC and SCC and both natural and artificial UVA/UVB radiation exposure, which are responsible for DNA mutations, alteration of the repair pathways, induction of oxidative stress, activation of the inflammatory process, and suppression of the antitumor immunity. […] The ageing population is another important factor that contributes to the increasing incidence, as the body loses its ability to repair and regenerate, to which the inflammatory status and physiological and/or drug-induced immunosuppression is added. […] The results obtained indicated associations or trends of association of age, gender, location and size of NMSC, which were specific to BCC and SCC. The aspects support the importance of clinical-epidemiological parameters in assessing the impact of NMSC on the exposed population.

• #27 Risk factors for non-melanoma skin cancer | Canadian Cancer Society

  https://cancer.ca/en/cancer-information/cancer-types/skin-non-melanoma/risks

  BCC is most common in people with a fair complexion. It has been most strongly linked to on-and-off exposure to UVR, sunburns and overexposure during the childhood or teenage years. […] SCC is most strongly linked to total lifetime sun exposure. This includes recreational and work-related exposure and being exposed to UVR a lot during childhood. […] People with fair or light-coloured skin have a higher risk of developing non-melanoma skin cancer than people with other skin types. People with blonde or red hair and blue, green or grey eyes also have a higher risk of developing non-melanoma skin cancer. Their risk is greater because people with these features have less melanin. Melanin is what gives colour to your skin, hair and eyes. Experts think that it also helps protect the skin from UVR. People with a fair or light-coloured skin who had very bad sunburns at an early age have the highest risk for non-melanoma skin cancers.

• #28 Advanced and Metastatic Non-Melanoma Skin Cancer: Epidemiology, Risk Factors, Clinical Features, and Treatment Options

  https://www.mdpi.com/2227-9059/12/7/1448

  NMSC stems from epidermal cells and exhibits typical epidemiological patterns, such as a higher occurrence among Caucasian populations. […] The development of BCC and cSCC can be due to exposure to physical carcinogens, ultraviolet radiation (UVR) stands out as the predominant risk factor. […] Additionally, multiple studies have indicated that individuals with lower socioeconomic status are more prone to developing non-melanoma skin cancers (NMSCs). […] It should be noted that numerous clinical trials are currently underway, exploring treatments for advanced and metastatic non-melanoma skin cancers, cSCC, and BCC.

• #29 Non-melanoma skin cancer incidence statistics | Cancer Research UK

  https://www.cancerresearchuk.org/health-professional/cancer-statistics/statistics-by-cancer-type/non-melanoma-skin-cancer/incidence

  The number of new non-melanoma skin cancer cases on average each year in the UK is projected to rise from more than 188,000 cases in 2023-2025 to more than 262,000 cases in 2038-2040. […] Non-melanoma skin cancer incidence rates are projected to rise by 14% in the UK between 2023-2025 and 2038-2040, to 310 cases per 100,000 people on average each year by 2038-2040. […] Non-melanoma skin cancer incidence rates (European age-standardised (AS) rates) in England in females are 40% lower in the most deprived quintile compared with the least, and in males are 42% lower in the most deprived quintile compared with the least (2013-2017). […] It is estimated that there are around 25,000 fewer cases of non-melanoma skin cancer each year in England than there would be if every deprivation quintile had the same age-specific crude incidence rates as the least deprived quintile.

• #30 Non-melanoma skin cancer incidence statistics | Cancer Research UK

  https://www.cancerresearchuk.org/health-professional/cancer-statistics/statistics-by-cancer-type/non-melanoma-skin-cancer/incidence

  New cases of non-melanoma skin cancer, 2016-2018, UK […] Peak rate of non-melanoma skin cases, 2016-2018, UK […] Change in non-melanoma skin cancer incidence rates since the early 1990s, UK […] 43% of non-melanoma skin cancer cases in the UK are in females, and 57% are in males. […] Non-melanoma skin cancer incidence rates (European age-standardised (AS) rate) for persons are significantly higher than the UK average in Wales, significantly lower than the UK average in Scotland and Northern Ireland, and similar to the UK average in England. […] For non-melanoma skin cancer, differences between countries largely reflect differences in diagnosis and data recording. […] Non-melanoma skin cancer incidence is strongly related to age, with the highest incidence rates being in older people. In the UK in 2016-2018, on average each year almost half of new cases (48%) were in people aged 75 and over.

• #31 Basal Cell Carcinoma: Practice Essentials, Background, Pathophysiology

  https://emedicine.medscape.com/article/276624-overview

  The likelihood of developing BCC increases with age. Data indicate that BCC incidence is far higher (more than 100-fold) in persons aged 55-70 years than in those aged 20 years and younger. Patients 50-80 years of age are affected most often. The median age at diagnosis is 67 years and the mean age is 64 years. […] Nevertheless, BCC can develop in teenagers and appears frequently in fair-skinned patients aged 30-50 years. Approximately 5% to 15% of cases of BCC occur in patients aged 20-40 years. Aggressive-growth types of BCC are more frequently noted in patients younger than 35 years than in older individuals. […] Zhang et al reported an inverse association between body mass index (BMI) and onset of BCC before age 40 years. The multivariate odds ratio for early-onset BCC in obese versus normal individuals was 0.43 for adult BMI and 0.54 for BMI at age 18.

• #32 Basal Cell Carcinoma: Practice Essentials, Background, Pathophysiology

  https://emedicine.medscape.com/article/276624-overview

  BCC is the least likely cancer to metastasize. BCC differs from squamous cell carcinoma, which accounts for 16% of skin cancers and is more life-threatening. […] Although BCC is observed in people of all races and skin types, dark-skinned individuals are rarely affected; BCC is most often found in light-skinned individuals (type 1 or type 2 skin). Those with type 1 skin are very fair and have red or blond hair and freckles; these individuals always burn and never tan. Those with type 2 skin are fair and burn easily while tanning minimally. Whites of Celtic ancestry have the highest risk for BCC. Incidence is low in persons with type 5 and 6 skin. […] Historically, men are affected twice as often as women. The higher incidence in men is probably due to increased recreational and occupational exposure to the sun, although these differences are becoming less significant with changes in lifestyle. The current male-to-female ratio is approximately 2.1:1.

• #33 Nationwide Trends in the Incidence of Melanoma and Non-melanoma Skin Cancers from 1999 to 2014 in South Korea

  https://www.e-crt.org/journal/view.php?number=2759

  The age-standardized incidence rates of cutaneous melanoma, squamous cell carcinoma, and basal cell carcinoma during 1999-2014 were 0.66, 1.34, and 2.45 per 100,000 people for men, and 0.58, 1.04, and 2.07 per 100,000 for women, respectively. […] The incidence rate of squamous cell carcinoma has increased more rapidly in women (AAPC, 6.8 [95% CI, 5.3 to 8.4]) than in men (AAPC, 3.3 [95% CI, 2.6 to 4.0]). […] Although the incidence of both basal cell carcinoma and squamous cell carcinoma has increased in the Western countries, incidence trends of non-melanoma skin cancer varied according to subtype in the Asian countries. […] Our findings also show an increase in the incidence of squamous cell carcinoma and basal cell carcinoma in both sexes in South Korea, but an increasing trend in the incidence of melanoma was observed only in women. Further studies are needed to investigate the causes of the increased incidence of these skin cancers in South Korea.

• #34 Non-melanoma skin cancer incidence statistics | Cancer Research UK

  https://www.cancerresearchuk.org/health-professional/cancer-statistics/statistics-by-cancer-type/non-melanoma-skin-cancer/incidence

  New cases of non-melanoma skin cancer, 2016-2018, UK […] Peak rate of non-melanoma skin cases, 2016-2018, UK […] Change in non-melanoma skin cancer incidence rates since the early 1990s, UK […] 43% of non-melanoma skin cancer cases in the UK are in females, and 57% are in males. […] Non-melanoma skin cancer incidence rates (European age-standardised (AS) rate) for persons are significantly higher than the UK average in Wales, significantly lower than the UK average in Scotland and Northern Ireland, and similar to the UK average in England. […] For non-melanoma skin cancer, differences between countries largely reflect differences in diagnosis and data recording. […] Non-melanoma skin cancer incidence is strongly related to age, with the highest incidence rates being in older people. In the UK in 2016-2018, on average each year almost half of new cases (48%) were in people aged 75 and over.

• #35 Non-Melanoma Skin Cancer: Statistical Associations between Clinical Parameters

  https://pmc.ncbi.nlm.nih.gov/articles/PMC9289586/

  According to the latest data, 3.6 million cases of BCC and 1.8 million cases of SCC are diagnosed annually in the United States. The incidence increases with age, and also multiplicity of SCC has been correlated with age. The prevalence values revealed significant increase during the last 20 years, 35% for BCC and 133% for SCC. Most NMSCs have a good prognosis and a low metastatic rate. […] Although for NMSC the impact on mortality is low, globally it causes 5,400 deaths per month, most of which are attributed to SCC. The United States reports 15,000 deaths annually from SCC. Survival is as low as 10-20% for metastatic SCC, this type being responsible for 75% of deaths caused by NMSC. […] The aim of this study was to assess the epidemiological development trends of BCC and SCC, and to analyze the associations between representative clinical parameters.

• #36 Non-Melanoma Skin Cancer: Statistical Associations between Clinical Parameters

  https://pmc.ncbi.nlm.nih.gov/articles/PMC9289586/

  According to the latest data, 3.6 million cases of BCC and 1.8 million cases of SCC are diagnosed annually in the United States. The incidence increases with age, and also multiplicity of SCC has been correlated with age. The prevalence values revealed significant increase during the last 20 years, 35% for BCC and 133% for SCC. Most NMSCs have a good prognosis and a low metastatic rate. […] Although for NMSC the impact on mortality is low, globally it causes 5,400 deaths per month, most of which are attributed to SCC. The United States reports 15,000 deaths annually from SCC. Survival is as low as 10-20% for metastatic SCC, this type being responsible for 75% of deaths caused by NMSC. […] The aim of this study was to assess the epidemiological development trends of BCC and SCC, and to analyze the associations between representative clinical parameters.

• #37 Non-Melanoma Skin Cancer: Statistical Associations between Clinical Parameters

  https://pmc.ncbi.nlm.nih.gov/articles/PMC9289586/

  According to the latest data, 3.6 million cases of BCC and 1.8 million cases of SCC are diagnosed annually in the United States. The incidence increases with age, and also multiplicity of SCC has been correlated with age. The prevalence values revealed significant increase during the last 20 years, 35% for BCC and 133% for SCC. Most NMSCs have a good prognosis and a low metastatic rate. […] Although for NMSC the impact on mortality is low, globally it causes 5,400 deaths per month, most of which are attributed to SCC. The United States reports 15,000 deaths annually from SCC. Survival is as low as 10-20% for metastatic SCC, this type being responsible for 75% of deaths caused by NMSC. […] The aim of this study was to assess the epidemiological development trends of BCC and SCC, and to analyze the associations between representative clinical parameters.

• #38 Skin cancer

  https://www.aad.org/media/stats-skin-cancer

  Research has shown that patients with darker skin tones are less likely than patients with lighter skin tones to survive melanoma. (18-21) […] Twenty-two percent of melanoma cases in African American patients are diagnosed when the cancer has spread to nearby lymph nodes, while 14% are diagnosed when the cancer has spread to distant lymph nodes and other organs. (22) […] Invasive melanoma rates among individuals younger than age 50 have stabilized in women and declined by about 1% per year in men since the early 2000s. (6) […] In adults 50 or older, the rates continue to increase in women by about 3% per year but have stabilized in men in recent years. (6) […] The vast majority of skin cancer deaths are from melanoma. (6) […] Nearly 20 Americans die from melanoma every day. In 2025, it is estimated that 8,430 deaths will be attributed to melanoma 5,470 men and 2,960 women. (6)

• #39 Non Melanoma Skin Cancer and Subsequent Cancer Risk | PLOS One

  https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0099674

  Several studies have shown an increased risk of cancer after non melanoma skin cancers (NMSC) but the individual risk factors underlying this risk have not been elucidated, especially in relation to sun exposure and skin sensitivity to sunlight. […] The non melanoma skin cancers (NMSC) are the most frequently diagnosed malignancies in the United States with an estimated 900,000 to 1,200,000 new cases diagnosed each year. The two major types of NMSC, basal cell (BCC) and squamous cell carcinoma (SCC), have a relatively small impact on mortality but their public health impact is considerable. Dramatic increases in incidence have been documented in recent decades. […] Several studies have reported that individuals diagnosed with non melanoma skin cancers have higher subsequent or prior diagnoses of second primary malignancies by about 2060%.

• #40 Non Melanoma Skin Cancer and Subsequent Cancer Risk | PLOS One

  https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0099674

  By virtue of their high frequency and low mortality, non melanoma skin cancers offer an excellent opportunity to study the factors that put some individuals at increased risk of multiple malignancies. […] Our population-based study indicates an increased cancer risk after NMSC that cannot be fully explained by known cancer risk factors. […] The risk of a subsequent cancer (other than NMSC) was higher after basal cell carcinoma (BCC) than squamous cell carcinoma (SCC) compared to controls. […] An over 3-fold risk of melanoma after SCC and BCC was observed, even after further adjustment for sun exposure-related factors and family history of skin cancer. […] In men, prostate cancer incidence was higher after BCC compared to controls. […] The increased cancer risk after SCC appeared to be largely confined to those with SCC diagnosed before the age of 60.

• #41 Non Melanoma Skin Cancer and Subsequent Cancer Risk | PLOS One

  https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0099674

  By virtue of their high frequency and low mortality, non melanoma skin cancers offer an excellent opportunity to study the factors that put some individuals at increased risk of multiple malignancies. […] Our population-based study indicates an increased cancer risk after NMSC that cannot be fully explained by known cancer risk factors. […] The risk of a subsequent cancer (other than NMSC) was higher after basal cell carcinoma (BCC) than squamous cell carcinoma (SCC) compared to controls. […] An over 3-fold risk of melanoma after SCC and BCC was observed, even after further adjustment for sun exposure-related factors and family history of skin cancer. […] In men, prostate cancer incidence was higher after BCC compared to controls. […] The increased cancer risk after SCC appeared to be largely confined to those with SCC diagnosed before the age of 60.

• #42 Skin carcinomas linked to increased risk of other cancers

  https://theconversation.com/skin-carcinomas-linked-to-increased-risk-of-other-cancers-24066

  We also identified that those who had NMSC before the age of 25 were 53 times more likely to get bone cancer, 26 times more likely to get blood cancers, 20 times more likely to get brain cancer, and 14 times more likely to get any cancer excluding those of the skin. […] Our study shows that NMSC susceptibility is not only a marker of people who have spent too much time in the sun. It is also an important indicator of susceptibility to malignant tumours and the risk is especially high among people who develop NMSC at a young age. […] The recognition that NMSC patients are cancer-prone individuals, especially when diagnosed with their skin cancer at a young age, allows public health agencies to examine options to better target cancer screening.

• #43 Epidemiology of melanoma and nonmelanoma skin cancer–the role of sunlight – PubMed

  https://pubmed.ncbi.nlm.nih.gov/18348450/

  Melanoma and nonmelanoma skin cancer (NMSC) are now the most common types of cancer in white populations. Both tumor entities show an increasing incidence rate worldwide but a stable or decreasing mortality rate. The rising incidence rates of NMSC are probably caused by a combination of increased sun exposure or exposure to ultraviolet (UV) light, increased outdoor activities, changes in clothing style, increased longevity, ozone depletion, genetics and in some cases, immune suppression. […] Epidemiological studies have confirmed the hypothesis that the majority of all melanoma cases are caused, at least in part, by excessive exposure to sunlight. […] In contrast to squamous cell carcinoma, melanoma risk seems not to be associated with cumulative, but intermittent exposure to sunlight. Therefore campaigns for prevention and early detection are necessary.

• #44 The incidence and clinical analysis of non-melanoma skin cancer | Scientific Reports

  https://www.nature.com/articles/s41598-021-83502-8

  Non-melanoma skin cancers (NMSCs) are the most common malignancies diagnosed in Caucasian populations. Basal cell carcinoma (BCC) is the most frequent skin cancer, followed by squamous cell carcinoma (SCC). Unfortunately, most European cancer registries do not record individual types of NMSC. […] To evaluate the incidence of primary BCCs and SCCs regarding age, sex, tumour site and tumour subtype to determine trends in epidemiology of both cancers. […] Non-melanoma skin cancers (NMSCs) are the most common human malignancies, with steadily rising incidence. The term NMSC refers to all non-melanoma malignant neoplasms affecting the skin. The main types of NMSC, basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), account for about 99% of all NMSCs. […] Although NMSC are 1820 times more frequent than cutaneous melanoma, there is little epidemiological data for those tumour types.

• #45 Melanoma of the Skin Statistics | Skin Cancer | CDC

  https://www.cdc.gov/skin-cancer/statistics/index.html

  Skin cancer is the most common form of cancer in the United States. Central cancer registries collect data on melanoma of the skin and nonepithelial skin cancers such as Merkel cell carcinoma. […] Data on basal cell and squamous cell carcinomas, the most common types of skin cancer, are not normally collected by central cancer registries. […] An examination of Medical Expenditure Panel Survey data suggests that each year, about 6.1 million adults are treated for basal cell and squamous cell carcinomas at a cost of about $8.9 billion. […] Cancer Statistics At a Glance: See rates or numbers of melanomas of the skin or melanoma of the skin deaths for the entire United States and individual states. Also, see the top 10 cancers for men and women. […] Cancers by Age, Sex, Race, and Ethnicity: See rates or numbers of melanomas of the skin or melanoma of the skin deaths by race/ethnicity, sex, and age group. […] Trends: See how the rates of melanomas of the skin or melanoma of the skin deaths changed over time for the entire United States and individual states.

• #46 Risk factors for non-melanoma skin cancer | Canadian Cancer Society

  https://cancer.ca/en/cancer-information/cancer-types/skin-non-melanoma/risks

  A risk factor is something that increases the risk of developing cancer. It could be a behaviour, substance or condition. Most cancers are the result of many risk factors. The most important risk factor for non-melanoma skin cancer is ultraviolet radiation (UVR) from the sun and indoor tanning. […] Non-melanoma skin cancer is the most common cancer diagnosed in Canadians. It makes up at least 40% of all new cancer cases in Canada. […] Statistics for non-melanoma skin cancers show that the chance of developing non-melanoma skin cancer increases with age. Most new cases are diagnosed in people between 80 and 90 years of age. But most cancer registries in Canada do not collect information about non-melanoma skin cancers. This is because these cancers are hard to keep track of. The information often doesnt get reported because non-melanoma skin cancer is usually diagnosed and treated easily in a doctors office.

• #47

  https://ehinz.ac.nz/indicators/uv-exposure/non-melanoma-skin-cancer/

  This section provides statistics on non-melanoma skin cancer deaths in Aotearoa New Zealand. […] In 2019, 175 people died from non-melanoma skin cancer (NMSC) in New Zealand. Males represented roughly two-thirds of these deaths (115 male deaths, compared with 60 female deaths). […] The NMSC mortality rate was 1.7 deaths per 100,000 in 2019 (95%CI 1.41.9). Males have consistently had higher mortality rates than females over the period monitored. […] The New Zealand Cancer Registry does not require notification of non-melanoma skin cancers. For this reason, an indicator on non-melanoma skin cancer registrations is not possible.

• #48 Disease Management: Nonmelanoma Skin Cancer

  https://www.clevelandclinicmeded.com/medicalpubs/diseasemanagement/dermatology/nonmelanoma-skin-cancer/

  Compared with BCC, the incidence of SCC seems to be increasing more rapidly, with an estimated lifetime risk of 9% to 14% among men and 4% to 9% among women. […] The most significant risk factors for the development of SCC include sun exposure, fair skin, age, and immunosuppression. […] With the increased incidence, associated morbidity, and cost of treating SCC in the United States, there has been increased interest in prevention and screening. […] The AAD recommends at least annual screening of patients diagnosed with SCC or BCC. […] This recommendation is based on studies that have identified an increased risk of additional NMSC as well as melanoma in individuals that have had at least 1 NMSCs. […] In fact, according to Wehner et al, patients with a history of 2 or more NMSC have an 82.0% risk of an additional NMSC at 5 years and a 91.2% risk of an additional NMSC at 10 years.

• #49 Disease Management: Nonmelanoma Skin Cancer

  https://www.clevelandclinicmeded.com/medicalpubs/diseasemanagement/dermatology/nonmelanoma-skin-cancer/

  Compared with BCC, the incidence of SCC seems to be increasing more rapidly, with an estimated lifetime risk of 9% to 14% among men and 4% to 9% among women. […] The most significant risk factors for the development of SCC include sun exposure, fair skin, age, and immunosuppression. […] With the increased incidence, associated morbidity, and cost of treating SCC in the United States, there has been increased interest in prevention and screening. […] The AAD recommends at least annual screening of patients diagnosed with SCC or BCC. […] This recommendation is based on studies that have identified an increased risk of additional NMSC as well as melanoma in individuals that have had at least 1 NMSCs. […] In fact, according to Wehner et al, patients with a history of 2 or more NMSC have an 82.0% risk of an additional NMSC at 5 years and a 91.2% risk of an additional NMSC at 10 years.

• #50 Epidemiology of melanoma and nonmelanoma skin cancer–the role of sunlight – PubMed

  https://pubmed.ncbi.nlm.nih.gov/18348450/

  Melanoma and nonmelanoma skin cancer (NMSC) are now the most common types of cancer in white populations. Both tumor entities show an increasing incidence rate worldwide but a stable or decreasing mortality rate. The rising incidence rates of NMSC are probably caused by a combination of increased sun exposure or exposure to ultraviolet (UV) light, increased outdoor activities, changes in clothing style, increased longevity, ozone depletion, genetics and in some cases, immune suppression. […] Epidemiological studies have confirmed the hypothesis that the majority of all melanoma cases are caused, at least in part, by excessive exposure to sunlight. […] In contrast to squamous cell carcinoma, melanoma risk seems not to be associated with cumulative, but intermittent exposure to sunlight. Therefore campaigns for prevention and early detection are necessary.

• #51 Changing trends in the disease burden of non-melanoma skin cancer globally from 1990 to 2019 and its predicted level in 25 years | BMC Cancer | Full Text

  https://bmccancer.biomedcentral.com/articles/10.1186/s12885-022-09940-3

  The disease burden of non-melanoma skin cancer (NMSC) has become a significant public health threat. […] The disease burden was significantly higher in males than in females in 2019. […] The better the socio-economic development, the heavier the disease burden of NMSC. […] The age-standardized incidence rate (ASIR) of NMSC increased from 54.08/100,000 in 1990 to 79.10/100,000 in 2019, with an estimated annual percentage change (EAPC) of 1.78. […] Our predictions suggested that the number of new cases, deaths, and DALYs attributable to NMSC would increase by at least 1.5 times from 2020 to 2044. […] The disease burden attributable to NMSC will continue to increase or remain stable at high levels. […] This is the first systematic assessment and prediction of the disease burden of non-melanoma skin cancer worldwide. […] The disease burden will continue to increase or remain relatively stable at high levels in the future.

• #52 Common skin lesions. Epidemiology of non-melanoma skin cancer

  https://dermnetnz.org/cme/lesions/epidemiology-of-non-melanoma-skin-cancer

  The Cancer Society of New Zealand has estimated that 50,000 new cases of non-melanoma skin cancer occur in New Zealand each year, by far the most common of all cancers. […] Some populations are at significantly greater risk of developing non-melanocytic skin cancers, especially basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). […] Immunosuppression results in a greater number of cancers and more aggressive tumours, most often observed in organ transplant patients on long term azathioprine and ciclosporin. […] In contrast to BCC, cumulative sun exposure is the greatest risks factor for SCC. […] General population screening is an unproven public health measure and is not recommended by the cancer societies in Australia and New Zealand. […] Measures to reduce the incidence of skin cancer (primary prevention) may be through governmental or non-governmental health or educational individuals or organisations.

• #53 Common skin lesions. Epidemiology of non-melanoma skin cancer

  https://dermnetnz.org/cme/lesions/epidemiology-of-non-melanoma-skin-cancer

  The Cancer Society of New Zealand has estimated that 50,000 new cases of non-melanoma skin cancer occur in New Zealand each year, by far the most common of all cancers. […] Some populations are at significantly greater risk of developing non-melanocytic skin cancers, especially basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). […] Immunosuppression results in a greater number of cancers and more aggressive tumours, most often observed in organ transplant patients on long term azathioprine and ciclosporin. […] In contrast to BCC, cumulative sun exposure is the greatest risks factor for SCC. […] General population screening is an unproven public health measure and is not recommended by the cancer societies in Australia and New Zealand. […] Measures to reduce the incidence of skin cancer (primary prevention) may be through governmental or non-governmental health or educational individuals or organisations.

• #54 Skin cancer

  https://www.aad.org/media/stats-skin-cancer

  Research has shown that patients with darker skin tones are less likely than patients with lighter skin tones to survive melanoma. (18-21) […] Twenty-two percent of melanoma cases in African American patients are diagnosed when the cancer has spread to nearby lymph nodes, while 14% are diagnosed when the cancer has spread to distant lymph nodes and other organs. (22) […] Invasive melanoma rates among individuals younger than age 50 have stabilized in women and declined by about 1% per year in men since the early 2000s. (6) […] In adults 50 or older, the rates continue to increase in women by about 3% per year but have stabilized in men in recent years. (6) […] The vast majority of skin cancer deaths are from melanoma. (6) […] Nearly 20 Americans die from melanoma every day. In 2025, it is estimated that 8,430 deaths will be attributed to melanoma 5,470 men and 2,960 women. (6)

• #55 Advanced and Metastatic Non-Melanoma Skin Cancer: Epidemiology, Risk Factors, Clinical Features, and Treatment Options

  https://www.mdpi.com/2227-9059/12/7/1448

  Non-melanoma skin cancers (NMSC) form the majority of skin cancers, with basal cell carcinoma (BCC) being the most common and cutaneous squamous cell carcinoma (cSCC) being second. Prolonged ultraviolet (UV) exposure, aging, male gender, and immunosuppression represent most of the causes of this category of diseases. […] The incidence of NMSC has steadily increased by around 3% a year for BCC. […] Overall, NMSCs occur in around 2 million people globally each year. Their prevalence varies based on the population discussed. BCC is much higher in white populations (75–80% of skin cancers) when compared to darker skin tones (20–30%). […] While rarely fatal, BCC is potentially disfiguring and harmful to local tissues, making its increase in incidence (3% yearly) problematic. […] The market size of the skin cancer treatment market was valued at USD 7.2 billion in 2021 and is estimated to double by 2031 to around USD 14.5 billion.

• #56

• #57 Non-Melanoma Skin Cancer: Statistical Associations between Clinical Parameters

  https://pmc.ncbi.nlm.nih.gov/articles/PMC9289586/

  Non-melanoma skin cancer (NMSC) represent an important health problem in medical practice. This is the most frequent type of cancer and its incidence is constantly increasing. Basal cell carcinoma and squamous cell carcinoma constitute the majority of NMSC, respectively 70% and 25% of total cases. The present retrospective study was conducted over a one-year period and included 439 cases of NMSC, of which 336 BCC and 103 SCC. We analyzed a series of clinical parameters: gender, age, tumor size and tumor topography. The statistical analysis of the investigated parameters indicated gender-age associations for BCC, and topography-gender, as well as topography-age for SCC. […] Non-melanoma skin cancers (NMSCs) represent an important health problem in medical practice, being the most frequent types of cancer. Their incidence is constantly increasing, accounting for 90% of all malignant skin tumors, and studies suggest that this trend will continue until at least the year 2040. Between 2007-2017, the incidence of NMSCs increased by 33%, reaching 7.7 million cases worldwide. In the last decade, in Europe, the incidence of BCC has increased annually by 5%, and some studies on SCC show that the incidence is rising and tends to approach that of BCC.

• #58 Advanced and Metastatic Non-Melanoma Skin Cancer: Epidemiology, Risk Factors, Clinical Features, and Treatment Options

  https://www.mdpi.com/2227-9059/12/7/1448

  Non-melanoma skin cancers (NMSC) form the majority of skin cancers, with basal cell carcinoma (BCC) being the most common and cutaneous squamous cell carcinoma (cSCC) being second. Prolonged ultraviolet (UV) exposure, aging, male gender, and immunosuppression represent most of the causes of this category of diseases. […] The incidence of NMSC has steadily increased by around 3% a year for BCC. […] Overall, NMSCs occur in around 2 million people globally each year. Their prevalence varies based on the population discussed. BCC is much higher in white populations (75–80% of skin cancers) when compared to darker skin tones (20–30%). […] While rarely fatal, BCC is potentially disfiguring and harmful to local tissues, making its increase in incidence (3% yearly) problematic. […] The market size of the skin cancer treatment market was valued at USD 7.2 billion in 2021 and is estimated to double by 2031 to around USD 14.5 billion.

• #59 Global, regional, and national trends in the burden of melanoma and non-melanoma skin cancer: insights from the global burden of disease study 1990–2021 | Scientific Reports

  https://www.nature.com/articles/s41598-025-90485-3

  This study examines global, regional, and national trends in melanoma and non-melanoma skin cancer (NMSC) burden from 1990 to 2021, their socioeconomic associations, and projects future trends. […] The global burden of skin cancers has shown significant growth over the study period, with the age-standardized incidence rate (ASIR) rising globally (Estimated Annual Percentage Change, EAPC=1.94%) from 1990 to 2021. […] In 2021, the most recent year covered, the global incidence of skin cancers was 6.64 million cases, with an ASIR of 77.66 per 100,000 and a disability-adjusted life years (DALYs) burden of 2.89 million cases. […] Skin cancer incidence is rising globally, driven by demographic changes, increased UV exposure, and improved detection. […] The burden of melanoma has decreased, which may be related to advances in treatment.

• #60 Epidemiology of Skin Cancer in 2024 | IntechOpen

  https://www.intechopen.com/chapters/1195964

  NMSC rates have increased significantly over the last several decades, with studies showing that the incidence of BCC has risen by 145% and SCC by 263% between the 1970s and the 2010s. […] In Europe, NMSC is also one of the most commonly diagnosed cancers, though incidence varies by region. […] The European Academy of Dermatology and Venereology (EADV) has reported an annual increase of 38% in NMSC cases over recent decades. […] Australia and New Zealand have the highest reported rates of NMSC in the world, with Australia recording an incidence of over 1000 cases per 100,000 people per year. […] In Asia, the incidence of NMSC is generally lower than in Western countries, though it is on the rise in some regions. […] NMSC incidence in Africa is lower than in regions with predominantly lighter-skinned populations, although the data are limited.

• #61 Basal Cell Carcinoma: Practice Essentials, Background, Pathophysiology

  https://emedicine.medscape.com/article/276624-overview

  BCC is the least likely cancer to metastasize. BCC differs from squamous cell carcinoma, which accounts for 16% of skin cancers and is more life-threatening. […] Although BCC is observed in people of all races and skin types, dark-skinned individuals are rarely affected; BCC is most often found in light-skinned individuals (type 1 or type 2 skin). Those with type 1 skin are very fair and have red or blond hair and freckles; these individuals always burn and never tan. Those with type 2 skin are fair and burn easily while tanning minimally. Whites of Celtic ancestry have the highest risk for BCC. Incidence is low in persons with type 5 and 6 skin. […] Historically, men are affected twice as often as women. The higher incidence in men is probably due to increased recreational and occupational exposure to the sun, although these differences are becoming less significant with changes in lifestyle. The current male-to-female ratio is approximately 2.1:1.

• #62 Changing trends in the disease burden of non-melanoma skin cancer globally from 1990 to 2019 and its predicted level in 25 years | BMC Cancer | Full Text

  https://bmccancer.biomedcentral.com/articles/10.1186/s12885-022-09940-3

  The disease burden of non-melanoma skin cancer (NMSC) has become a significant public health threat. […] The disease burden was significantly higher in males than in females in 2019. […] The better the socio-economic development, the heavier the disease burden of NMSC. […] The age-standardized incidence rate (ASIR) of NMSC increased from 54.08/100,000 in 1990 to 79.10/100,000 in 2019, with an estimated annual percentage change (EAPC) of 1.78. […] Our predictions suggested that the number of new cases, deaths, and DALYs attributable to NMSC would increase by at least 1.5 times from 2020 to 2044. […] The disease burden attributable to NMSC will continue to increase or remain stable at high levels. […] This is the first systematic assessment and prediction of the disease burden of non-melanoma skin cancer worldwide. […] The disease burden will continue to increase or remain relatively stable at high levels in the future.

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