Nietolerancja pokarmowa
Etiologia i przyczyny

Nietolerancja pokarmowa to reakcja organizmu na określone składniki pokarmowe niezwiązana z układem immunologicznym, wynikająca głównie z zaburzeń trawienia lub metabolizmu. Najczęstszą formą jest nietolerancja laktozy, dotykająca około 65% populacji, spowodowana niedoborem enzymu laktazy, co prowadzi do fermentacji niestrawionej laktozy w jelicie grubym i objawów takich jak wzdęcia, bóle brzucha, gazy i biegunka. Inne mechanizmy obejmują niedobory enzymów (np. oksydazy diaminowej w nietolerancji histaminy), reakcje na naturalne związki chemiczne (salicylany, aminy biogenne), dodatki do żywności (siarczyny, glutaminian monosodowy, benzoesany) oraz zaburzenia mikrobioty jelitowej i zwiększoną przepuszczalność jelitową. Nietolerancje często współistnieją z chorobami przewodu pokarmowego, takimi jak IBS, IBD czy celiakia, a także mają podłoże genetyczne i środowiskowe. Czynniki psychologiczne, w tym stres, mogą nasilać objawy poprzez wpływ na mikrobiotę i funkcjonowanie jelit.

Etiologia nietolerancji pokarmowej

Nietolerancja pokarmowa definiowana jest jako reakcja organizmu na określone pokarmy lub składniki pokarmowe, która nie jest związana z układem immunologicznym. W przeciwieństwie do alergii pokarmowej, nietolerancja pokarmowa dotyczy głównie układu pokarmowego i jest spowodowana trudnościami w trawieniu lub metabolizowaniu określonych produktów spożywczych.12 Szacuje się, że nietolerancje pokarmowe dotykają nawet 20% światowej populacji, a ich liczba wydaje się wzrastać w ostatnich latach.34

Przyczyny nietolerancji pokarmowych są złożone i nie do końca poznane. W przeciwieństwie do alergii pokarmowej, w której uczestniczy układ odpornościowy reagujący na białka pokarmowe, nietolerancja pokarmowa wynika z zaburzeń funkcjonowania układu trawiennego lub metabolicznego.56 Mechanizmy prowadzące do rozwoju nietolerancji pokarmowych są różnorodne i obejmują czynniki zarówno genetyczne, jak i środowiskowe.7

Niedobór enzymów trawiennych

Jedną z najczęstszych przyczyn nietolerancji pokarmowej jest niedobór lub brak określonych enzymów trawiennych, niezbędnych do prawidłowego trawienia i wchłaniania składników pokarmowych.89 Klasycznym przykładem jest nietolerancja laktozy, która występuje, gdy organizm nie produkuje wystarczającej ilości enzymu laktazy, potrzebnego do rozkładu laktozy – cukru występującego w mleku i produktach mlecznych.10

Laktaza jest enzymem wytwarzanym w błonie śluzowej jelita cienkiego i jej niedobór prowadzi do niepełnego trawienia laktozy, przez co niestrawiony cukier mleczny trafia do jelita grubego, gdzie jest fermentowany przez bakterie jelitowe.11 Proces ten powoduje wytwarzanie gazów i innych produktów fermentacji, prowadząc do objawów takich jak wzdęcia, bóle brzucha, gazy i biegunka.12 Według badań, nietolerancja laktozy dotyka około 65% światowej populacji, co czyni ją najczęstszą formą nietolerancji pokarmowej.13

Podobnie, nietolerancja fruktozy może wynikać z niedoboru specyficznych enzymów lub transporterów, takich jak GLUT-5 i GLUT-2, odpowiedzialnych za transport fruktozy przez błonę komórkową enterocytów.14 W przypadku dziedzicznej nietolerancji fruktozy mamy do czynienia z rzadkim zaburzeniem genetycznym, polegającym na braku enzymu rozkładającego fruktozę, co prowadzi do jej gromadzenia się w organizmie i poważnych konsekwencji metabolicznych.15

Innym przykładem nietolerancji spowodowanej niedoborem enzymatycznym jest niedobór oksydazy diaminowej (DAO), enzymu odpowiedzialnego za rozkład histaminy, co może prowadzić do nietolerancji histaminy.16 Osoby z nietolerancją histaminy doświadczają reakcji po spożyciu pokarmów bogatych w histaminę, takich jak sery dojrzewające, wino, fermentowane produkty czy marynowane pokarmy.17

Reakcje na naturalne związki chemiczne w żywności

Wiele nietolerancji pokarmowych wynika z reakcji na naturalnie występujące związki chemiczne w żywności, które mają działanie farmakologiczne.18 Do tej kategorii należą nietolerancje na histaminę, salicylany, aminy biogenne i inne substancje bioaktywne.19

Salicylany to naturalne związki chemiczne występujące w wielu produktach roślinnych, przypominające swoją strukturą i działaniem kwas acetylosalicylowy (aspirynę). Występują one w dużych ilościach w herbacie, kawie, miodzie, owocach, warzywach, przyprawach i orzechach.20 Nietolerancja salicylanów dotyka około 2,5% populacji europejskiej i może powodować różnorodne objawy, od dolegliwości oddechowych (zablokowany lub cieknący nos, zapalenie zatok, polipy nosa, astma oskrzelowa), po problemy żołądkowo-jelitowe, w tym wzdęcia, gazy, biegunki, a w rzadkich przypadkach zapalenie jelita grubego z zwężeniami i owrzodzeniami.21

Patogeneza nietolerancji salicylanów opiera się na hamowaniu cyklooksygenazy-1 przez salicylany i inne niesteroidowe leki przeciwbólowe, ale także przez żywność zawierającą salicylany i inne kwasy (takie jak kwas benzoesowy lub barwniki), co prowadzi do zmniejszonej syntezy prostaglandyn.22

Aminy wazoaktywne, takie jak tyramina, serotonina i histamina, mogą również wywoływać reakcje nietolerancji. Osoby z nietolerancją amin nie są w stanie prawidłowo metabolizować tych związków.23 Objawy nietolerancji histaminy są bardzo zróżnicowane i mogą dotyczyć prawie wszystkich narządów, od objawów skórnych po dolegliwości żołądkowo-jelitowe.24

Reakcje na dodatki do żywności

Wiele osób doświadcza nietolerancji na dodatki do żywności, takie jak konserwanty, barwniki, wzmacniacze smaku czy przeciwutleniacze. Substancje te są dodawane do żywności w celu poprawy jej wyglądu, smaku lub ochrony przed rozwojem bakterii i grzybów.25

Siarczyny (dodatki o numerach E220-228) są powszechnie stosowane jako konserwanty w suszonych owocach, winie i innych produktach. Mogą one wywoływać reakcje nietolerancji u osób wrażliwych, prowadząc do objawów takich jak zatkany nos, świszczący oddech i niskie ciśnienie krwi.2627

Glutaminian monosodowy (MSG, dodatki o numerach E621-625) jest popularnym wzmacniaczem smaku dodawanym do wielu potraw, szczególnie w kuchni azjatyckiej. U niektórych osób może wywoływać reakcje nietolerancji, manifestujące się bólami głowy, uczuciem pieczenia, nudnościami i zmęczeniem.28

Benzoesany, często używane w napojach bezalkoholowych jako konserwanty, również mogą być przyczyną reakcji nietolerancji u wrażliwych osób.29

Zaburzenia mikrobioty jelitowej

Coraz więcej dowodów wskazuje na istotną rolę mikrobioty jelitowej w rozwoju nietolerancji pokarmowych.30 Dysbioza, czyli zaburzenie równowagi mikrobiomu jelitowego, może prowadzić do zwiększonej przepuszczalności jelitowej (tzw. zespołu nieszczelnego jelita), co ułatwia przenikanie nieprawidłowo strawionych cząsteczek pokarmowych przez barierę jelitową do krwiobiegu.31

Przewlekłe stosowanie antybiotyków, stres, choroby zapalne czy inne czynniki wpływające na skład mikrobioty jelitowej mogą zwiększać ryzyko rozwoju nietolerancji pokarmowych.32

Osoby z przerostem bakteryjnym jelita cienkiego (SIBO) są szczególnie narażone na rozwój nietolerancji pokarmowych, ponieważ bakterie bytujące w niewłaściwym miejscu przewodu pokarmowego fermentują składniki pokarmowe, prowadząc do produkcji nadmiernych ilości gazów i innych metabolitów.33

Badania wykazały również związek między zmianami w składzie bakterii jelitowych a rozwojem nietolerancji glutenu i celiakii. W jednym z badań zaobserwowano, że zmiana składu bakterii w jelitach była związana z rozwojem celiakii u osób, u których zdiagnozowano tę chorobę 15 lat później.34

Strukturalne i funkcjonalne przyczyny nietolerancji pokarmowej

Nietolerancje pokarmowe można podzielić na funkcjonalne i strukturalne, w zależności od mechanizmu, który leży u ich podstawy.35

Funkcjonalna nietolerancja pokarmowa wynika z izolowanych zaburzeń funkcjonalnych, takich jak niedobór enzymów trawiennych, bez widocznych zmian anatomicznych czy morfologicznych w przewodzie pokarmowym. Przykładem jest nietolerancja laktozy spowodowana niedoborem laktazy.36

Strukturalna nietolerancja pokarmowa wynika natomiast z nieprawidłowości anatomicznych lub morfologicznych przewodu pokarmowego, takich jak uchyłki jelitowe, które mogą prowadzić do produkcji nieprawidłowych produktów fermentacji i wtórnych objawów żołądkowo-jelitowych, takich jak wzdęcia i biegunka.37

Choroby przewlekłe przewodu pokarmowego, takie jak zespół jelita drażliwego (IBS), choroba Leśniowskiego-Crohna, wrzodziejące zapalenie jelita grubego czy celiakia, mogą również przyczyniać się do rozwoju nietolerancji pokarmowych.38 Osoby z tymi schorzeniami często rozwijają wtórne nietolerancje na różne pokarmy.39

Czynniki genetyczne i środowiskowe

Nietolerancje pokarmowe mają często podłoże genetyczne, co tłumaczy ich częstsze występowanie w określonych grupach etnicznych.40 Na przykład nietolerancja laktozy jest częstsza wśród osób pochodzenia azjatyckiego i afrykańskiego, podczas gdy u osób pochodzenia północnoeuropejskiego występuje rzadziej.41

Czynniki środowiskowe, takie jak dieta bogata w wysoko przetworzoną żywność, stosowanie pestycydów, konserwantów i innych dodatków do żywności, a także narażenie na zanieczyszczenia środowiskowe, mogą również przyczyniać się do rozwoju nietolerancji pokarmowych.42

Istnieje teoria, że zmiany w naszej współczesnej diecie, polegające na większym spożyciu żywności przetworzonej, a mniejszym naturalnej, przyczyniają się do wzrostu częstości występowania nietolerancji pokarmowych. Niektórzy eksperci sugerują, że nasze organizmy mogą nie rozpoznawać zmodyfikowanych białek w żywności genetycznie modyfikowanej lub przetworzonej.43

Czynniki psychologiczne w nietolerancji pokarmowej

Aspekty psychologiczne mogą również odgrywać rolę w rozwoju i manifestacji nietolerancji pokarmowych. U niektórych osób, konkretne pokarmy mogą wywoływać nudności i inne problemy trawienne z przyczyn psychologicznych.44

Stres przewlekły może wpływać na ogólny stan zdrowia i funkcjonowanie układu trawiennego, co może prowadzić do objawów sugerujących nietolerancję pokarmową, gdy w rzeczywistości przyczyną może być niepokój psychiczny lub stres.45

Badania pokazują, że reakcja stresowa może zmieniać naturalną równowagę zdrowych bakterii w jelitach, powodując, że ekologia jelitowa przesuwa się na korzyść bardziej niekorzystnej grupy bakterii, co może przyczyniać się do rozwoju objawów nietolerancji pokarmowej.46

Specyficzne mechanizmy nietolerancji pokarmowych

Nietolerancja laktozy

Nietolerancja laktozy, będąca najczęstszą formą nietolerancji pokarmowej, dotyka około 65% światowej populacji.47 Wynika ona z niedoboru enzymu laktazy, który jest niezbędny do trawienia laktozy – cukru występującego w mleku i produktach mlecznych.48

Laktoza jest disacharydem, który musi zostać rozłożony na glukozę i galaktozę przez enzym laktazę, aby mógł być wchłonięty w jelicie cienkim. Przy niedoborze laktazy, niestrawiona laktoza przechodzi do jelita grubego, gdzie jest fermentowana przez bakterie jelitowe. Proces ten prowadzi do produkcji gazów (wodoru, metanu, dwutlenku węgla) oraz kwasów tłuszczowych o krótkich łańcuchach, co wywołuje objawy takie jak wzdęcia, gazy, bóle brzucha i biegunka.49

Nietolerancja laktozy może być wrodzona, ale częściej rozwija się wraz z wiekiem, gdy produkcja laktazy stopniowo maleje.50 Jest to normalny proces ewolucyjny, ponieważ większość ssaków po okresie karmienia mlekiem matki traci zdolność do trawienia laktozy. Zdolność do trawienia laktozy w dorosłym życiu, tzw. przetrwała laktaza, jest mutacją genetyczną, która rozpowszechniła się głównie wśród populacji, które historycznie zajmowały się hodowlą bydła i spożywały duże ilości nabiału.51

Nietolerancja glutenu i celiakia

Nietolerancja glutenu, znana również jako nieceliakalna wrażliwość na gluten (NCGS – Non-Celiac Gluten Sensitivity), jest stanem, w którym spożycie glutenu wywołuje objawy podobne do celiakii, ale bez charakterystycznych zmian w błonie śluzowej jelita cienkiego i bez typowej odpowiedzi immunologicznej.52

Celiakia natomiast jest chorobą autoimmunologiczną, w której spożycie glutenu prowadzi do uszkodzenia kosmków jelitowych, co upośledza wchłanianie składników odżywczych. W celiakii układ odpornościowy reaguje na gluten, wytwarzając przeciwciała, które atakują błonę śluzową jelita cienkiego.53

Mechanizmy nietolerancji glutenu nie są do końca poznane, ale istnieje kilka hipotez. Jedna z nich sugeruje, że gluten lub inne składniki pszenicy, takie jak inhibitory amylazy/trypsyny (ATI), mogą aktywować wrodzoną odpowiedź immunologiczną, prowadząc do stanu zapalnego i objawów żołądkowo-jelitowych.54

U osób z nietolerancją glutenu, pewne komponenty żywności zawierającej gluten (takie jak pszenica) mogą zwiększać przepuszczalność jelit. Oznacza to, że mikroby mogą przekraczać barierę jelitową i wchodzić w interakcję z układem odpornościowym, wywołując łagodną reakcję zapalną wraz z objawami takimi jak ból brzucha, biegunka i wzdęcia.55

Badania wykazują, że nietolerancja glutenu często współistnieje z zespołem jelita drażliwego, a objawy obu stanów mogą być trudne do rozróżnienia.56

Nietolerancja histaminy

Nietolerancja histaminy wynika z zaburzenia równowagi między gromadzoną lub spożywaną histaminą a zmniejszoną zdolnością organizmu do jej rozkładu.57 Histamina jest naturalnie występującym związkiem chemicznym, który odgrywa ważną rolę w procesach zapalnych i alergicznych, a także działa jako neuroprzekaźnik.

Głównym enzymem odpowiedzialnym za rozkład histaminy jest oksydaza diaminowa (DAO). Niedobór tego enzymu może prowadzić do nagromadzenia histaminy w organizmie i rozwoju objawów nietolerancji.58 Nietolerancja histaminy może być również związana z mastocytozą, stanem charakteryzującym się zwiększoną liczbą komórek tucznych w organizmie, lub tzw. zespołem aktywacji komórek tucznych (MCAS).59

Objawy nietolerancji histaminy są bardzo zróżnicowane i mogą dotyczyć prawie wszystkich narządów. Obejmują one: zaczerwienienie skóry, bóle głowy, pokrzywkę, świąd, niepokój, skurcze żołądka, biegunkę i niskie ciśnienie krwi.60

Pokarmy bogate w histaminę obejmują fermentowane produkty (ser, wino, piwo, kiszona kapusta), wędzone mięsa, niektóre owoce morza, a także produkty, które stymulują uwalnianie histaminy w organizmie, takie jak alkohol czy kakao.61

Nietolerancja FODMAP

FODMAP to akronim od angielskich słów: Fermentable Oligosaccharides, Disaccharides, Monosaccharides And Polyols, co oznacza fermentujące oligosacharydy, disacharydy, monosacharydy i poliole. Są to krótkołańcuchowe węglowodany i alkohole cukrowe, które są słabo wchłaniane w jelicie cienkim.62

Nietolerancje FODMAP są bardzo powszechne u osób z zespołem jelita drażliwego (IBS).63 FODMAP nie są wchłaniane w jelicie cienkim w znaczącym stopniu i przechodzą do jelita grubego, gdzie są fermentowane przez bakterie jelitowe, co prowadzi do produkcji gazów, wzdęć, bólów brzucha i zmian w rytmie wypróżnień.64

Do produktów bogatych w FODMAP należą: pszenica, żyto, niektóre owoce (jabłka, gruszki, mango), warzywa (cebula, czosnek, brokuły), mleko i produkty mleczne, a także produkty zawierające fruktozę (miód, agawa) czy poliole (sorbitol, mannitol).65

Nietolerancja fruktozy

Nietolerancja fruktozy może mieć charakter wrodzony lub nabyty. Dziedziczna nietolerancja fruktozy jest rzadką chorobą genetyczną, spowodowaną brakiem enzymu aldolazy B, niezbędnego do metabolizmu fruktozy w wątrobie. Prowadzi to do gromadzenia się fruktozo-1-fosforanu, co zaburza metabolizm glukozy i może prowadzić do hipoglikemii, uszkodzenia wątroby i nerek.66

Znacznie częstsza jest nabyta nietolerancja fruktozy (malabsorpcja fruktozy), która wynika z ograniczonej zdolności jelita cienkiego do wchłaniania fruktozy. W normalnych warunkach fruktoza jest transportowana przez błonę komórkową enterocytów za pomocą specyficznego białka transportowego GLUT-5. Gdy ilość fruktozy przekracza zdolność transportową GLUT-5 lub gdy działanie tego transportera jest upośledzone, fruktoza przechodzi do jelita grubego, gdzie jest fermentowana przez bakterie, prowadząc do produkcji gazów i objawów nietolerancji.67

Objawy nietolerancji fruktozy obejmują refluks, gazy, biegunkę, nudności, ból brzucha, wymioty i wzdęcia.68

Nietolerancja fruktozy może być wrodzona lub nabyta w wyniku uszkodzenia jelit, cukrzycy, celiakii lub choroby Leśniowskiego-Crohna.69

Współbystępowanie z innymi schorzeniami

Nietolerancje pokarmowe często współistnieją z innymi schorzeniami, co może utrudniać diagnostykę i leczenie. Zrozumienie tych zależności jest kluczowe dla skutecznego zarządzania nietolerancjami pokarmowymi.

Zespół jelita drażliwego a nietolerancja pokarmowa

Zespół jelita drażliwego (IBS) jest częstym zaburzeniem czynnościowym jelit, charakteryzującym się bólem brzucha, wzdęciami i zmianami w rytmie wypróżnień. Badania wskazują, że większość osób z IBS ma nietolerancje pokarmowe.70

IBS może powodować uciążliwe i często bolesne objawy związane z jelitami, czasami w reakcji na spożycie określonych pokarmów.71 Nietolerancje FODMAP są szczególnie powszechne wśród osób z IBS, a dieta niskofodmapowa jest często stosowana jako metoda leczenia objawów IBS.72

Badania wykazały również, że osoby z IBS mogą mieć zwiększoną przepuszczalność jelitową, co może ułatwiać rozwój nietolerancji pokarmowych.73

Choroby zapalne jelit

Choroby zapalne jelit (IBD), takie jak choroba Leśniowskiego-Crohna i wrzodziejące zapalenie jelita grubego, mogą zwiększać podatność na nietolerancje pokarmowe.74

Przewlekły stan zapalny w jelitach może prowadzić do uszkodzenia błony śluzowej jelita i zwiększonej przepuszczalności jelitowej, co może sprzyjać rozwojowi różnych nietolerancji pokarmowych. Ponadto, leczenie IBD może wpływać na mikrobiotę jelitową, co również może przyczyniać się do rozwoju nietolerancji pokarmowych.75

Celiakia i nietolerancja glutenu

Celiakia jest chorobą autoimmunologiczną, w której spożycie glutenu prowadzi do uszkodzenia błony śluzowej jelita cienkiego. Nie jest to forma nietolerancji pokarmowej, ale przewlekłe schorzenie trawienne wywołane spożyciem glutenu.76

Nietolerancja glutenu (nieceliakalna wrażliwość na gluten) natomiast jest stanem, w którym spożycie glutenu wywołuje objawy podobne do celiakii, ale bez specyficznych zmian w jelicie i bez typowej odpowiedzi immunologicznej charakterystycznej dla celiakii.77

Badania wskazują, że osoby z chorobami wątroby są od czterech do sześciu razy bardziej narażone na rozwój nietolerancji glutenu i celiakii, co wskazuje na wyraźny związek między nietolerancją glutenu a rozwojem chorób wątroby, i odwrotnie.78

Mastocytoza i zespół aktywacji komórek tucznych

Mastocytoza to stan charakteryzujący się zwiększoną liczbą i aktywnością komórek tucznych w różnych tkankach i narządach. Komórki tuczne odgrywają kluczową rolę w reakcjach alergicznych i zapalnych, a ich nadmierna aktywacja może prowadzić do objawów przypominających nietolerancję pokarmową.79

Objawy mastocytozy mogą obejmować nie tylko objawy skórne, ale także epizodyczne dolegliwości żołądkowo-jelitowe, takie jak nudności, pieczenie w brzuchu, biegunka, choroba wrzodowa, krwawienia z przewodu pokarmowego i zaburzenia wchłaniania.80

Patogeneza mastocytozy układowej opiera się głównie na mutacji przezbłonowej receptora kinazy tyrozynowej c-kit, odpowiedzialnego za proliferację i dojrzewanie komórek tucznych.81

Czynniki środowiskowe i żywieniowe

Wpływ diety współczesnej

Choroby zapalne i procesy degeneracyjne znacznie nasiliły się w ostatnich dziesięcioleciach i przebiegają równolegle z industrializacją żywności i współczesnym stylem życia.82 Dieta uboga w składniki odżywcze, a bogata w kalorie, może osłabiać układ odpornościowy. Nieodpowiednia dieta jest główną przyczyną niedoborów odporności na świecie.83

Powtarzające się stosowanie niektórych powszechnych pokarmów oraz rozległe stosowanie chemikaliów, takich jak pestycydy i dodatki, barwniki, konserwanty i aromaty, zwiększyło ryzyko rozwoju nietolerancji.84

Wiele osób z meticulousnie zdrowymi dietami ma ukryte nietolerancje pokarmowe (zwane także wrażliwościami), które potajemnie sabotują ich zdrowie.85

Stosowanie pestycydów i dodatków do żywności

Stosowanie pestycydów i dodatków do żywności może powodować, że organizm myli chemikalia z pokarmami, z którymi są one używane.86 Wiele osób sugeruje, że nasze organizmy nie rozpoznają zmodyfikowanych białek w żywności genetycznie modyfikowanej lub przetworzonej.87

Alergie pokarmowe są również na wzrost z powodu napływu przetworzonych i pakowanych pokarmów, które niosą ze sobą wiele dodatków, barwników i syntetycznych chemikaliów.88

Higiena i ekspozycja na mikroorganizmy

Jedna z teorii sugeruje, że wzrost liczby alergii pokarmowych w erze nowożytnej jest spowodowany zakłóceniem równowagi mikroorganizmów, które kolonizują jelita.89 Być może ten styl życia wywołał zmiany w naszych bakteriach jelitowych, które doprowadziły do większej nietolerancji pokarmowej.90

Inna teoria sugeruje, że dzieci coraz częściej dorastają w środowiskach wolnych od zarazków. Oznacza to, że ich układy odpornościowe mogą nie otrzymywać wystarczającej wczesnej ekspozycji na drobnoustroje potrzebne do prawidłowego rozwoju. Jest to znane jako hipoteza higieny.91

Stres i czynniki psychologiczne

Dobrostan psychologiczny może wpływać na ogólne zdrowie i stan układu trawiennego. Może to prowadzić do kwestionowania, czy ktoś ma nietolerancje pokarmowe, gdy w rzeczywistości stres psychologiczny i/lub stres może być winowajcą zaostrzenia problemów żołądkowych.92

Nagła wrażliwość na niektóre pokarmy może również wystąpić w wyniku przyjmowania leków (np. antybiotyków) przez dłuższy czas lub z powodu stresującego wydarzenia życiowego, takiego jak utrata pracy, rozstanie lub rozwód, poddanie się poważnej operacji lub walka z poważną chorobą.93

Badania pokazują, że reakcja stresowa może zmieniać naturalną równowagę zdrowych bakterii w jelitach, powodując, że ekologia jelitowa przesuwa się na korzyść bardziej wrogiej grupy bakterii.94 Inne badania pokazują, że stres i zaburzenia nastroju, takie jak depresja, wzmacniają się nawzajem i przyczyniają się do przeciekającego jelita i dysbiozy, tworząc reakcję zapalną, która zaczyna się w jelitach, ale jak pożar, rozprzestrzenia się po całym ciele.95

U niektórych osób określone pokarmy mogą wywoływać nudności i inne problemy trawienne z przyczyn psychologicznych. W takich przypadkach, gdy dany pokarm jest podawany w zamaskowany sposób, może być dobrze tolerowany.96

Niediagnostyczne biomarkery dla nietolerancji pokarmowych

Brak wiarygodnych biomarkerów diagnostycznych dla wszystkich nietolerancji pokarmowych powoduje niemożność ukierunkowania na określone pokarmy u danej osoby.97

Ze względu na brak zwalidowanych biomarkerów diagnostycznych, definicja nieceliakialnej wrażliwości na gluten według literatury naukowej obejmuje przypadki, w których osoby reagują na dietę bezglutenową i reagują na ponowne wprowadzenie glutenu w porównaniu z placebo.98

Nie ma testów diagnostycznych do oceny wrażliwości na dodatki do żywności lub chemikalia.99

Badania wykazały, że nietolerancje FODMAP (krótko łańcuchowych węglowodanów) są powszechne u osób z zespołem jelita drażliwego (IBS), ale brak specyficznych biomarkerów utrudnia diagnostykę.100

Podsumowanie etiologii nietolerancji pokarmowej

Nietolerancja pokarmowa jest złożonym stanem, którego etiologia nie została jeszcze w pełni wyjaśniona. W przeciwieństwie do alergii pokarmowej, która jest mediowana przez układ immunologiczny, nietolerancja pokarmowa wynika z różnorodnych mechanizmów, w tym niedoborów enzymatycznych, reakcji na naturalne związki chemiczne w żywności, zaburzeń mikrobioty jelitowej, czynników genetycznych i środowiskowych oraz aspektów psychologicznych.101

Najczęstszą przyczyną nietolerancji pokarmowej jest niedobór określonych enzymów trawiennych, jak w przypadku nietolerancji laktozy, gdzie niewystarczająca ilość enzymu laktazy prowadzi do niepełnego trawienia laktozy i wynikających z tego objawów żołądkowo-jelitowych.102

Inne mechanizmy obejmują reakcje na naturalne związki chemiczne w żywności (takie jak histamina, salicylany, aminy biogenne), reakcje na dodatki do żywności (konserwanty, barwniki, wzmacniacze smaku), zaburzenia mikrobioty jelitowej i zwiększoną przepuszczalność jelitową, choroby przewodu pokarmowego (takie jak IBS, IBD, celiakia) oraz czynniki genetyczne i środowiskowe.103104

Czynniki psychologiczne, takie jak stres przewlekły, mogą również odgrywać rolę w rozwoju i manifestacji nietolerancji pokarmowych, wpływając na funkcjonowanie układu trawiennego i mikrobiotę jelitową.105

Pomimo postępów w zrozumieniu etiologii nietolerancji pokarmowych, wiele aspektów pozostaje niewyjaśnionych, a brak wiarygodnych biomarkerów diagnostycznych utrudnia precyzyjną diagnostykę i leczenie. Dalsze badania są niezbędne, aby lepiej zrozumieć złożone mechanizmy leżące u podstaw nietolerancji pokarmowych i opracować skuteczniejsze strategie diagnostyczne i terapeutyczne.106107

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  1. 12.04.2026
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Materiały źródłowe

  • #1 Food intolerance
    https://www.nhs.uk/conditions/food-intolerance/
    A food intolerance is caused by your body not being able to digest a certain food or an ingredient in food. […] Unlike a food allergy, a food intolerance is not caused by your immune system overreacting to certain types of food, which means you cannot have a serious allergic reaction.
  • #2 Food Intolerance | Children’s Hospital of Philadelphia
    https://www.chop.edu/conditions-diseases/food-intolerance
    People have a food intolerance when they have difficulty digesting certain foods and have an unpleasant physical reaction when they eat those foods. […] Food intolerances and food allergies are caused by different biological processes and are diagnosed and treated differently. The problem in food intolerance lies in the digestive system, not in the immune system as in food allergies, though the symptoms of the two types of food reactions can be similar. […] Food intolerance may be caused by: Lack of an enzyme needed to digest a certain food, or insufficient enzymes to digest a food fully. […] Sensitivity to certain chemicals in food. […] Irritable bowel syndrome (IBS). This chronic condition causes annoying and often painful abdominal and bowel symptoms, sometimes in reaction to eating particular foods. […] Psychological factors. For some people, certain foods can cause nausea and other digestive problems for psychological reasons.
  • #3 The 8 Most Common Food Intolerances
    https://www.healthline.com/nutrition/common-food-intolerances
    Food intolerance may cause symptoms similar to a food allergy in some people. […] Food intolerances and sensitivities are extremely common and seem to be on the rise. […] In fact, it’s estimated that up to 20% of the world’s population may have a food intolerance. […] Food intolerances and sensitivities can be hard to diagnose due to their wide range of symptoms. […] A food intolerance is not the same as a food allergy, although some of the symptoms may be similar. […] When you have a food intolerance, symptoms usually begin within a few hours of eating the food that you are intolerant to. […] Symptoms can be delayed by up to 48 hours and last for hours or even days, making the offending food especially difficult to pinpoint. […] While symptoms of food intolerances vary, they most often involve the digestive system, skin and respiratory system.
  • #4 The Differential Diagnosis of Food Intolerance
    https://pmc.ncbi.nlm.nih.gov/articles/PMC2695393/
    More than 20% of the population in industrialized countries suffer from food intolerance or food allergy. […] The majority of cases of food intolerance (15% to 20%) are due to non-immunological causes. These causes range from pseudoallergic reactions to enzymopathies, chronic infections, and psychosomatic reactions that are associated with food intolerance. […] The term food intolerance is used to describe a range of food related complaints of varying etiology. […] Food intolerance of functional origin is often caused only by an isolated functional disorder (such as lactase deficiency in the small intestine) and is initially unaccompanied by any other anatomical or morphological changes in the gastrointestinal tract. Food intolerance of structural etiology, on the other hand, has its origin in an anatomically and morphologically demonstrable disease involving a structural alteration in the gastrointestinal tract.
  • #5 Food Allergy and Food Intolerance – Causes, Symptoms, Treatments
    https://www.webmd.com/allergies/food-allergy-intolerances
    People often have an unpleasant reaction to something they ate and think they have a food allergy. But they may be having something else: a reaction called food intolerance. […] A food allergy is caused by your immune system reacting to the food when it doesn’t need to. […] With a food intolerance, your immune system isn’t responsible. Most of the time it’s a problem with digesting the food. […] Lactose intolerance, the most common food intolerance, affects at least 1 out of 10 people. Lactase is an enzyme in the lining of the gut. It breaks down lactose, a type of sugar in milk and other dairy products. If you don’t have enough lactase, you can’t digest lactose. Instead, bacteria eat the lactose, which creates gas, and you can get bloating, stomach pain, and diarrhea. […] Gluten intolerance is not the same as celiac disease. Celiac disease is caused by an abnormal immune response to gluten, a protein found in wheat and some other grains. Gluten intolerance, on the other hand, involves how the digestive system handles gluten. Both of these are different from food allergies. […] Some people may have a food intolerance with a psychological trigger. An unpleasant event, often during childhood, that’s tied to eating a particular food can bring on a rush of unpleasant sensations when you eat that food later, even as an adult.
  • #6 Azthena logo with the word Azthena
    https://www.news-medical.net/health/Causes-of-Food-Intolerance.aspx
    Food intolerance is a functional or structural intolerance to food, which is non-immunologic and non-toxic in origin, but is chemically based instead. […] A third type of food intolerance involves the effects produced by pharmacologically active amines and other compounds present in foods. […] Thus, food intolerance describes a range of food-related symptoms that are not immunologically-mediated. These account for the majority of food reactions. […] Functional food intolerance is not associated with structural abnormalities of the digestive tract, but may be due to an isolated enzyme deficiency. […] A prime example of functional food intolerance is lactose intolerance. […] Carbohydrate intolerances involve the inability to digest and absorb sorbitol, fructose or other simple sugars.
  • #7 What Causes Food Intolerances? A Comprehensive Guide – Healthpath
    https://healthpath.com/gut-health/what-causes-food-intolerances/
    Nobody really knows for sure what causes food intolerances. […] Research is beginning to help us uncover some of the likely reasons, but here at Healthpath we believe that food intolerances are at least partly caused by poor gut health. […] Food intolerances happen when your body reacts to food because its unable to digest or break it down. This can happen for endless reasons. For instance, your body may lack the enzyme to break down a particular part of that food. This is the case with the lactose in dairy, if you have a lactose intolerance. […] Food intolerances develop because of problems with the functioning of the digestive system, such as leaky gut. […] Nobody knows for sure why food intolerances (or allergies) develop. Experts have some ideas, but its important to say that at this stage, we dont have a lot of research to back these claims up.
  • #8 Food Intolerance | Children’s Hospital of Philadelphia
    https://www.chop.edu/conditions-diseases/food-intolerance
    People have a food intolerance when they have difficulty digesting certain foods and have an unpleasant physical reaction when they eat those foods. […] Food intolerances and food allergies are caused by different biological processes and are diagnosed and treated differently. The problem in food intolerance lies in the digestive system, not in the immune system as in food allergies, though the symptoms of the two types of food reactions can be similar. […] Food intolerance may be caused by: Lack of an enzyme needed to digest a certain food, or insufficient enzymes to digest a food fully. […] Sensitivity to certain chemicals in food. […] Irritable bowel syndrome (IBS). This chronic condition causes annoying and often painful abdominal and bowel symptoms, sometimes in reaction to eating particular foods. […] Psychological factors. For some people, certain foods can cause nausea and other digestive problems for psychological reasons.
  • #9 Food intolerance: Causes, types, symptoms, and diagnosis
    https://www.medicalnewstoday.com/articles/263965
    Food intolerances arise if the body is unable to digest a certain food. This impairment may be due to a lack of digestive enzymes or a sensitivity to certain chemicals. […] Food intolerances are more common in those with digestive system disorders, such as irritable bowel syndrome (IBS). According to the IBS network, most people with IBS have food intolerances. […] Lactose is a sugar that occurs in milk. People with lactose intolerance do not have enough lactase, an enzyme that breaks lactose into smaller molecules that the body can easily absorb through the intestine. […] Fructose is a sugar present in fruit, some vegetables, and honey. Although rare, fructose intolerance can also be due to the lack of an enzyme known as hereditary fructose intolerance. […] Gluten intolerance is also known as nonceliac gluten sensitivity. […] Food intolerances arise when the body cannot properly digest certain foods.
  • #10 Azthena logo with the word Azthena
    https://www.news-medical.net/health/Causes-of-Food-Intolerance.aspx
    Food intolerance is a functional or structural intolerance to food, which is non-immunologic and non-toxic in origin, but is chemically based instead. […] A third type of food intolerance involves the effects produced by pharmacologically active amines and other compounds present in foods. […] Thus, food intolerance describes a range of food-related symptoms that are not immunologically-mediated. These account for the majority of food reactions. […] Functional food intolerance is not associated with structural abnormalities of the digestive tract, but may be due to an isolated enzyme deficiency. […] A prime example of functional food intolerance is lactose intolerance. […] Carbohydrate intolerances involve the inability to digest and absorb sorbitol, fructose or other simple sugars.
  • #11 Azthena logo with the word Azthena
    https://www.news-medical.net/health/Causes-of-Food-Intolerance.aspx
    Lactase deficiency is the best known and is the cause of intolerance to milk and other dairy products, which contain lactose, also known as milk sugar. […] Other examples include the isolated or combined disaccharide malabsorption syndrome, which prevents the absorption of sucrose, lactose and other disaccharides, either one in particular or all together. […] When these sugars are not absorbed properly, they reach the large intestine in increased amounts, resulting in excessive fermentation and bacterial overgrowth. […] The production of osmotic sugars and their fermentation products in larger quantities causes symptoms, such as meteorism (i.e. the accumulation of excess gas in the gastrointestinal tract), flatulence and diarrhea. […] Diamine oxidase deficiency may cause histamine intolerance.
  • #12 Food allergy – Symptoms and causes – Mayo Clinic
    https://www.mayoclinic.org/diseases-conditions/food-allergy/symptoms-causes/syc-20355095
    Depending on the type of food intolerance you have, you may be able to eat small amounts of problem foods without a reaction. By contrast, if you have a true food allergy, even a tiny amount of the food may trigger an allergic reaction. […] One of the tricky aspects of diagnosing food intolerance is that some people are sensitive not to the food itself but to a substance or ingredient used in the preparation of the food. […] Common conditions that can cause symptoms mistaken for a food allergy include: Absence of an enzyme needed to fully digest a food. You may not have enough of some of the enzymes needed to digest certain foods. Insufficient amounts of the enzyme lactase, for example, reduce your ability to digest lactose, the main sugar in milk products. Lactose intolerance can cause bloating, cramping, diarrhea and excess gas.
  • #13 The 8 Most Common Food Intolerances
    https://www.healthline.com/nutrition/common-food-intolerances
    Food intolerances are commonly diagnosed by elimination diets specifically designed to narrow down offending foods or through other testing methods. […] Lactose intolerance is caused by a shortage of lactase enzymes, which causes an inability to digest lactose and results in digestive symptoms. […] In fact, it is estimated that 65% of the world’s population has trouble digesting lactose. […] Non-celiac gluten sensitivity is a milder form of gluten intolerance that has been estimated to impact anywhere from 0.5 to 13% of the population. […] Symptoms of non-celiac gluten sensitivity are similar to those of celiac disease. […] Some people are more sensitive to caffeine and experience reactions even after consuming a small amount. […] Symptoms of salicylate intolerance include stuffy nose, sinus infections, nasal and sinus polyps, asthma, diarrhea, gut inflammation, and hives.
  • #14 Azthena logo with the word Azthena
    https://www.news-medical.net/health/Causes-of-Food-Intolerance.aspx
    Other than enzyme deficiencies, transporter molecule defects may be present. […] These include defects in GLUT 5, which transports fructose, or GLUT 2 for glucose, galactose or fructose. […] The inability to transport these carbohydrates into the intestinal cells results in their metabolism in the large intestine where they are transported intact in large quantities. […] Patients who are at risk for bacterial overgrowth include those who have been surgically treated by bowel resection, or are on chronic treatment with proton pump inhibitors, such as ranitidine or omeprazole. […] This leads to symptoms of food intolerance following ingestion of a number of foods, due to the release of excessive bacterial decomposition products in the gut. […] Many foods contain compounds with intrinsic biologic activity, such as salicylates, biogenic amines, and other substances that may lead to intolerance due to enzyme deficiencies.
  • #15 Food intolerance: Causes, types, symptoms, and diagnosis
    https://www.medicalnewstoday.com/articles/263965
    Food intolerances arise if the body is unable to digest a certain food. This impairment may be due to a lack of digestive enzymes or a sensitivity to certain chemicals. […] Food intolerances are more common in those with digestive system disorders, such as irritable bowel syndrome (IBS). According to the IBS network, most people with IBS have food intolerances. […] Lactose is a sugar that occurs in milk. People with lactose intolerance do not have enough lactase, an enzyme that breaks lactose into smaller molecules that the body can easily absorb through the intestine. […] Fructose is a sugar present in fruit, some vegetables, and honey. Although rare, fructose intolerance can also be due to the lack of an enzyme known as hereditary fructose intolerance. […] Gluten intolerance is also known as nonceliac gluten sensitivity. […] Food intolerances arise when the body cannot properly digest certain foods.
  • #16 Azthena logo with the word Azthena
    https://www.news-medical.net/health/Causes-of-Food-Intolerance.aspx
    Lactase deficiency is the best known and is the cause of intolerance to milk and other dairy products, which contain lactose, also known as milk sugar. […] Other examples include the isolated or combined disaccharide malabsorption syndrome, which prevents the absorption of sucrose, lactose and other disaccharides, either one in particular or all together. […] When these sugars are not absorbed properly, they reach the large intestine in increased amounts, resulting in excessive fermentation and bacterial overgrowth. […] The production of osmotic sugars and their fermentation products in larger quantities causes symptoms, such as meteorism (i.e. the accumulation of excess gas in the gastrointestinal tract), flatulence and diarrhea. […] Diamine oxidase deficiency may cause histamine intolerance.
  • #17 Food intolerance – Australasian Society of Clinical Immunology and Allergy (ASCIA)
    https://www.allergy.org.au/patients/food-other-adverse-reactions/food-intolerance
    Adverse reactions to artificial preservatives such as sulfites (often used in dried fruits) and benzoates (often used in soft drinks) have been shown to cause symptoms. […] Symptoms caused by food intolerance can affect the: […] Lactose intolerance is an enzyme deficiency where people dont have enough lactase enzyme to break down lactose in their diet. […] Monosodium glutamate (MSG, additive numbers 621-625) is added to some foods to enhance flavour. […] Vasoactive amines include tyramine, serotonin, and histamine. […] Salicylates are natural aspirin-like compounds that are found in many herbs, spices, fruits, and vegetables. […] Toxins can cause severe symptoms. […] Irritants such as caffeine and curry can trigger indigestion in some people. […] Food intolerances can often be difficult to diagnose as symptoms can depend on the substance and amount eaten.
  • #18 Azthena logo with the word Azthena
    https://www.news-medical.net/health/Causes-of-Food-Intolerance.aspx
    Food intolerance is a functional or structural intolerance to food, which is non-immunologic and non-toxic in origin, but is chemically based instead. […] A third type of food intolerance involves the effects produced by pharmacologically active amines and other compounds present in foods. […] Thus, food intolerance describes a range of food-related symptoms that are not immunologically-mediated. These account for the majority of food reactions. […] Functional food intolerance is not associated with structural abnormalities of the digestive tract, but may be due to an isolated enzyme deficiency. […] A prime example of functional food intolerance is lactose intolerance. […] Carbohydrate intolerances involve the inability to digest and absorb sorbitol, fructose or other simple sugars.
  • #19 Food intolerance – Australasian Society of Clinical Immunology and Allergy (ASCIA)
    https://www.allergy.org.au/patients/food-other-adverse-reactions/food-intolerance
    Adverse reactions to artificial preservatives such as sulfites (often used in dried fruits) and benzoates (often used in soft drinks) have been shown to cause symptoms. […] Symptoms caused by food intolerance can affect the: […] Lactose intolerance is an enzyme deficiency where people dont have enough lactase enzyme to break down lactose in their diet. […] Monosodium glutamate (MSG, additive numbers 621-625) is added to some foods to enhance flavour. […] Vasoactive amines include tyramine, serotonin, and histamine. […] Salicylates are natural aspirin-like compounds that are found in many herbs, spices, fruits, and vegetables. […] Toxins can cause severe symptoms. […] Irritants such as caffeine and curry can trigger indigestion in some people. […] Food intolerances can often be difficult to diagnose as symptoms can depend on the substance and amount eaten.
  • #20 Food intolerance – Australasian Society of Clinical Immunology and Allergy (ASCIA)
    https://www.allergy.org.au/patients/food-other-adverse-reactions/food-intolerance
    Adverse reactions to artificial preservatives such as sulfites (often used in dried fruits) and benzoates (often used in soft drinks) have been shown to cause symptoms. […] Symptoms caused by food intolerance can affect the: […] Lactose intolerance is an enzyme deficiency where people dont have enough lactase enzyme to break down lactose in their diet. […] Monosodium glutamate (MSG, additive numbers 621-625) is added to some foods to enhance flavour. […] Vasoactive amines include tyramine, serotonin, and histamine. […] Salicylates are natural aspirin-like compounds that are found in many herbs, spices, fruits, and vegetables. […] Toxins can cause severe symptoms. […] Irritants such as caffeine and curry can trigger indigestion in some people. […] Food intolerances can often be difficult to diagnose as symptoms can depend on the substance and amount eaten.
  • #21 The Differential Diagnosis of Food Intolerance
    https://pmc.ncbi.nlm.nih.gov/articles/PMC2695393/
    Nontoxic reactions are divided into two further principal mechanisms: immunologically and non-immunologically mediated reactions. Overall, non-immunologically mediated reactions account for the majority of all reactions to food (15% to 20%). […] The range of differential diagnoses of the non-immunologically mediated forms of food intolerance further includes chronic infections (such as lambliasis), neuroendocrine tumors (such as carcinoid), and psychosomatic reactions that cause or can imitate symptoms of intolerance. […] The prevalence of true food allergy, i.e., immunologically mediated intolerance reactions, is only 2% to 5%. […] The differential diagnosis of food intolerance is broad. […] The prevalence of salicylate intolerance in Europe is 2.5%. […] The classical symptoms of salicylate intolerance are respiratory complaints (blocked or runny nose, sinusitis, nasal polyposis, bronchial asthma), but can also lead to gastrointestinal complaints with meteorism, flatulence, diarrhea and, rarely, to colitis with strictures and ulcers.
  • #22 The Differential Diagnosis of Food Intolerance
    https://pmc.ncbi.nlm.nih.gov/articles/PMC2695393/
    The pathogenesis of salicylate intolerance is based on an inhibition of cyclooxygenase-1 by salicylates and other non-steroidal pain medications, but also by salicylate-containing foods and other acids (such as benzoic acid or colorants) resulting in reduced prostaglandin synthesis. […] The symptoms of histamine intolerance are highly variable and affect almost all organs. […] The symptoms resemble those of the underlying diseases, most likely histamine intolerance or food allergy. […] The diagnosis has to be confirmed by a histological analysis of tissue (skin, gastrointestinal tract) or bone marrow biopsy to demonstrate mast cell infiltration. […] The symptoms of systemic mastocytosis can include not only cutaneous signs but also episodic gastrointestinal complaints such as nausea, burning abdominal pain, diarrhea, ulcer diseases, gastrointestinal bleeding and malabsorption.
  • #23 What Causes Sudden Food Intolerance? – New Life Nutrition
    https://www.newlifenutrition.com.au/food-intolerances-and-allergies/what-causes-sudden-food-intolerance/
    Similar to lactose intolerance, a study revealed that gluten sensitivity develops as people get older. […] This phenomenon is linked to the change in the bacterial composition in the intestines of the subjects who were diagnosed with coeliac disease 15 years later. […] Caffeine intolerance may be a result of your body’s decreasing ability to digest caffeine as you age, or stress-related. […] If you have an intolerance to amines, it means your body is unable to properly metabolise them. […] Histamine intolerance can be attributed to a deficiency of diamine oxidase and N-methyltransferase the enzymes responsible for breaking down histamine. […] Only a few types of food additives are believed to cause negative reactions in a very small population.
  • #24 The Differential Diagnosis of Food Intolerance
    https://pmc.ncbi.nlm.nih.gov/articles/PMC2695393/
    The pathogenesis of salicylate intolerance is based on an inhibition of cyclooxygenase-1 by salicylates and other non-steroidal pain medications, but also by salicylate-containing foods and other acids (such as benzoic acid or colorants) resulting in reduced prostaglandin synthesis. […] The symptoms of histamine intolerance are highly variable and affect almost all organs. […] The symptoms resemble those of the underlying diseases, most likely histamine intolerance or food allergy. […] The diagnosis has to be confirmed by a histological analysis of tissue (skin, gastrointestinal tract) or bone marrow biopsy to demonstrate mast cell infiltration. […] The symptoms of systemic mastocytosis can include not only cutaneous signs but also episodic gastrointestinal complaints such as nausea, burning abdominal pain, diarrhea, ulcer diseases, gastrointestinal bleeding and malabsorption.
  • #25 What is Food Intolerance? Causes, Symptoms, and Treatment
    https://www.kauveryhospital.com/blog/gastroenterology/what-is-food-intolerance/
    Food intolerance and food-related allergies are common problems, but they are different medical conditions and should not be confused. Food intolerance is a reaction of the digestive system when a portion of food eaten causes irritation to the system or is something that cannot be adequately digested. […] There is no single cause of food intolerance. In some cases, it is caused by a person not being able to produce the enzymes that are required to digest the proteins that some foods contain correctly. This is what causes lactose intolerance. Chemicals that are added to some foods are another common cause of intolerance. The additives are often introduced into foods to improve the colour (visual appeal), taste, or protection against bacteria and fungal growth. Monosodium glutamate (MSG) is a flavor enhancer that often causes intolerance. Substances known as sulfites which both occur naturally (as in the case of red wine) or are added to foods to prevent the development of mould are another common cause. Salicylates, a set of plant chemicals found in fruits, vegetables, coffee, beer, wine, and nuts are yet another cause. Some medications like aspirin also contain salicylates.
  • #26 The 8 Most Common Food Intolerances
    https://www.healthline.com/nutrition/common-food-intolerances
    The most common reason for histamine intolerance is impaired function of the enzymes responsible for breaking down histamine. […] Symptoms of histamine intolerance include flushing of the skin, headaches, hives, itching, anxiety, stomach cramps, diarrhea, and low blood pressure. […] FODMAP intolerances are very common in people with irritable bowel syndrome, or IBS. […] Symptoms of a FODMAP intolerance include bloating, diarrhea, gas, abdominal pain, and constipation. […] People who are intolerant to sulfites can experience symptoms like stuffy nose, wheezing, and low blood pressure. […] In people with fructose intolerance, fructose isn’t efficiently absorbed into the blood. […] Symptoms of fructose malabsorption include reflux, gas, diarrhea, nausea, abdominal pain, vomiting, and bloating. […] Food intolerances differ from allergies. Most do not trigger the immune system, and their symptoms are usually less severe. […] Many people are intolerant or hypersensitive to foods and additives like dairy products, caffeine, and gluten.
  • #27 Food intolerance – Australasian Society of Clinical Immunology and Allergy (ASCIA)
    https://www.allergy.org.au/patients/food-other-adverse-reactions/food-intolerance
    Adverse reactions to artificial preservatives such as sulfites (often used in dried fruits) and benzoates (often used in soft drinks) have been shown to cause symptoms. […] Symptoms caused by food intolerance can affect the: […] Lactose intolerance is an enzyme deficiency where people dont have enough lactase enzyme to break down lactose in their diet. […] Monosodium glutamate (MSG, additive numbers 621-625) is added to some foods to enhance flavour. […] Vasoactive amines include tyramine, serotonin, and histamine. […] Salicylates are natural aspirin-like compounds that are found in many herbs, spices, fruits, and vegetables. […] Toxins can cause severe symptoms. […] Irritants such as caffeine and curry can trigger indigestion in some people. […] Food intolerances can often be difficult to diagnose as symptoms can depend on the substance and amount eaten.
  • #28 Food intolerance – Australasian Society of Clinical Immunology and Allergy (ASCIA)
    https://www.allergy.org.au/patients/food-other-adverse-reactions/food-intolerance
    Adverse reactions to artificial preservatives such as sulfites (often used in dried fruits) and benzoates (often used in soft drinks) have been shown to cause symptoms. […] Symptoms caused by food intolerance can affect the: […] Lactose intolerance is an enzyme deficiency where people dont have enough lactase enzyme to break down lactose in their diet. […] Monosodium glutamate (MSG, additive numbers 621-625) is added to some foods to enhance flavour. […] Vasoactive amines include tyramine, serotonin, and histamine. […] Salicylates are natural aspirin-like compounds that are found in many herbs, spices, fruits, and vegetables. […] Toxins can cause severe symptoms. […] Irritants such as caffeine and curry can trigger indigestion in some people. […] Food intolerances can often be difficult to diagnose as symptoms can depend on the substance and amount eaten.
  • #29 Food intolerance – Australasian Society of Clinical Immunology and Allergy (ASCIA)
    https://www.allergy.org.au/patients/food-other-adverse-reactions/food-intolerance
    Adverse reactions to artificial preservatives such as sulfites (often used in dried fruits) and benzoates (often used in soft drinks) have been shown to cause symptoms. […] Symptoms caused by food intolerance can affect the: […] Lactose intolerance is an enzyme deficiency where people dont have enough lactase enzyme to break down lactose in their diet. […] Monosodium glutamate (MSG, additive numbers 621-625) is added to some foods to enhance flavour. […] Vasoactive amines include tyramine, serotonin, and histamine. […] Salicylates are natural aspirin-like compounds that are found in many herbs, spices, fruits, and vegetables. […] Toxins can cause severe symptoms. […] Irritants such as caffeine and curry can trigger indigestion in some people. […] Food intolerances can often be difficult to diagnose as symptoms can depend on the substance and amount eaten.
  • #30 What Causes Food Intolerances? A Comprehensive Guide – Healthpath
    https://healthpath.com/gut-health/what-causes-food-intolerances/
    Dysbiosis compromises your gut immunity and digestive power, and increases your chances of leaky gut (which has in fact been linked in research to food intolerances and allergies). […] The use of pesticides and food additives could mean that your body gets confused between the chemicals and the foods theyre used with. […] Many people suggest that our bodies cannot recognise the altered proteins in genetically modified or processed food. […] Our nutrient-poor, calorie-dense diets compromise our immune systems. Poor diets are the leading cause of immunodeficiency worldwide. […] However, we do know which foods or components of foods, to be more precise, are most likely to give you your symptoms. […] Many experts believe that food intolerances are at least partly caused by poor gut health and changes in your microbiome, brought on by illness, medications or pregnancy, for example.
  • #31 What Causes Food Intolerances? A Comprehensive Guide – Healthpath
    https://healthpath.com/gut-health/what-causes-food-intolerances/
    Dysbiosis compromises your gut immunity and digestive power, and increases your chances of leaky gut (which has in fact been linked in research to food intolerances and allergies). […] The use of pesticides and food additives could mean that your body gets confused between the chemicals and the foods theyre used with. […] Many people suggest that our bodies cannot recognise the altered proteins in genetically modified or processed food. […] Our nutrient-poor, calorie-dense diets compromise our immune systems. Poor diets are the leading cause of immunodeficiency worldwide. […] However, we do know which foods or components of foods, to be more precise, are most likely to give you your symptoms. […] Many experts believe that food intolerances are at least partly caused by poor gut health and changes in your microbiome, brought on by illness, medications or pregnancy, for example.
  • #32 FOOD SENSITIVITIES AND INTOLERANCE: FROM TRIGGERS TO TREATMENT (PT. 1) | Mya Care
    https://myacare.com/blog/food-sensitivities-and-intolerance-from-triggers-to-treatment-pt-1
    Chronic antibiotic use is associated with gut dysbiosis and stands as a substantial risk for inflammatory and allergic diseases, including chronic food sensitivities. […] The inability to properly digest one’s food can easily increase the risk of developing food sensitivities. […] As immune reactivity is often a component of adverse reactions to food, those with autoimmune diseases are typically at a higher risk for developing them compared to others. […] Exposure to toxins, pollutants, or chemicals is known to incite a direct loss of oral tolerance and promote sensitivity towards chemicals, inhaled substances, and cross-reactive food antigens. […] Nutritional deficiencies have been linked to an increased prevalence of allergies and food sensitivities.
  • #33 Azthena logo with the word Azthena
    https://www.news-medical.net/health/Causes-of-Food-Intolerance.aspx
    Other than enzyme deficiencies, transporter molecule defects may be present. […] These include defects in GLUT 5, which transports fructose, or GLUT 2 for glucose, galactose or fructose. […] The inability to transport these carbohydrates into the intestinal cells results in their metabolism in the large intestine where they are transported intact in large quantities. […] Patients who are at risk for bacterial overgrowth include those who have been surgically treated by bowel resection, or are on chronic treatment with proton pump inhibitors, such as ranitidine or omeprazole. […] This leads to symptoms of food intolerance following ingestion of a number of foods, due to the release of excessive bacterial decomposition products in the gut. […] Many foods contain compounds with intrinsic biologic activity, such as salicylates, biogenic amines, and other substances that may lead to intolerance due to enzyme deficiencies.
  • #34 What Causes Sudden Food Intolerance? – New Life Nutrition
    https://www.newlifenutrition.com.au/food-intolerances-and-allergies/what-causes-sudden-food-intolerance/
    Similar to lactose intolerance, a study revealed that gluten sensitivity develops as people get older. […] This phenomenon is linked to the change in the bacterial composition in the intestines of the subjects who were diagnosed with coeliac disease 15 years later. […] Caffeine intolerance may be a result of your body’s decreasing ability to digest caffeine as you age, or stress-related. […] If you have an intolerance to amines, it means your body is unable to properly metabolise them. […] Histamine intolerance can be attributed to a deficiency of diamine oxidase and N-methyltransferase the enzymes responsible for breaking down histamine. […] Only a few types of food additives are believed to cause negative reactions in a very small population.
  • #35 The Differential Diagnosis of Food Intolerance
    https://pmc.ncbi.nlm.nih.gov/articles/PMC2695393/
    More than 20% of the population in industrialized countries suffer from food intolerance or food allergy. […] The majority of cases of food intolerance (15% to 20%) are due to non-immunological causes. These causes range from pseudoallergic reactions to enzymopathies, chronic infections, and psychosomatic reactions that are associated with food intolerance. […] The term food intolerance is used to describe a range of food related complaints of varying etiology. […] Food intolerance of functional origin is often caused only by an isolated functional disorder (such as lactase deficiency in the small intestine) and is initially unaccompanied by any other anatomical or morphological changes in the gastrointestinal tract. Food intolerance of structural etiology, on the other hand, has its origin in an anatomically and morphologically demonstrable disease involving a structural alteration in the gastrointestinal tract.
  • #36 Azthena logo with the word Azthena
    https://www.news-medical.net/health/Causes-of-Food-Intolerance.aspx
    Food intolerance is a functional or structural intolerance to food, which is non-immunologic and non-toxic in origin, but is chemically based instead. […] A third type of food intolerance involves the effects produced by pharmacologically active amines and other compounds present in foods. […] Thus, food intolerance describes a range of food-related symptoms that are not immunologically-mediated. These account for the majority of food reactions. […] Functional food intolerance is not associated with structural abnormalities of the digestive tract, but may be due to an isolated enzyme deficiency. […] A prime example of functional food intolerance is lactose intolerance. […] Carbohydrate intolerances involve the inability to digest and absorb sorbitol, fructose or other simple sugars.
  • #37 Azthena logo with the word Azthena
    https://www.news-medical.net/health/Causes-of-Food-Intolerance.aspx
    Some intolerance-like symptoms are due to chronic infections of the digestive organs, carcinoid tumors, psychosomatic reactions, and chronic bowel disease. […] Structural intolerance is due to abnormal structure of the digestive tract; for example, this occurs with intestinal diverticula. […] The production of abnormal fermentation products results in secondary gastrointestinal symptoms, such as bloating and diarrhea.
  • #38 Food Intolerance: Symptoms, Causes and Treatment Options
    https://my.clevelandclinic.org/health/diseases/21688-food-intolerance
    Food intolerance means your gut is sensitive to certain foods and cant tolerate them. […] People with food intolerances often dont make enough of a particular enzyme that the digestive system needs to break down a certain food or ingredient. Experts arent sure why some people develop food intolerances. […] Certain gastrointestinal conditions may make you more prone to food sensitivities. These conditions include: Celiac disease. Inflammatory bowel disease (IBD), including Crohns disease and ulcerative colitis.
  • #39 Food intolerance: Causes, types, symptoms, and diagnosis
    https://www.medicalnewstoday.com/articles/263965
    Food intolerances arise if the body is unable to digest a certain food. This impairment may be due to a lack of digestive enzymes or a sensitivity to certain chemicals. […] Food intolerances are more common in those with digestive system disorders, such as irritable bowel syndrome (IBS). According to the IBS network, most people with IBS have food intolerances. […] Lactose is a sugar that occurs in milk. People with lactose intolerance do not have enough lactase, an enzyme that breaks lactose into smaller molecules that the body can easily absorb through the intestine. […] Fructose is a sugar present in fruit, some vegetables, and honey. Although rare, fructose intolerance can also be due to the lack of an enzyme known as hereditary fructose intolerance. […] Gluten intolerance is also known as nonceliac gluten sensitivity. […] Food intolerances arise when the body cannot properly digest certain foods.
  • #40 Food Intolerance | Asthma & Allergy Center
    https://www.priyabansal.com/food-intolerance.php
    Food intolerance occurs when an individual has an adverse reaction to certain food or foods. Food intolerance is differentiated from food allergy because the former denotes a sensitivity, the latter a reaction of the immune system. […] There seem to be both genetic and environmental factors at play in the development of food intolerance. Since being intolerant to particular foods is more common in certain ethnic groups, there is clearly a genetic component to the condition. Reasons for food intolerance have not been wholly deciphered, however, though the following causes have been isolated: […] The causes of food intolerance may be difficult to assess, particularly if they have a psychological root. In such cases, when the affecting food is served in a disguised fashion it may be well-tolerated.
  • #41 What Causes Food Intolerances? Can They Develop Over Time? – CircleDNA
    https://circledna.com/blog/causes-of-food-intolerance/?srsltid=AfmBOopCEnGKvlAU6jQH4cmIIJBUhUBAZOTo29xKa_HJLo_3bUCpAmrK
    Food intolerances are a common issue for many people, and the associated health problems can be quite severe. The question is, where do these food intolerances come from? Food intolerances aren’t the same as a food allergy, where consuming a problem food can be potentially life-threatening. With food intolerance or food sensitivity, you’re more likely to have negative side effects when you eat a certain kind of food. A food intolerance might be something you’re born with. Genes can sometimes lead to someone having a higher chance of intolerance. For instance, people of East Asian descent are more likely to have an inherited genetic mutation that causes alcohol intolerance. However, anyone can have the enzyme problem that causes this condition. Other kinds of food intolerance naturally progress over time. Look at lactose intolerance, for example. According to the National Institutes of Health, about 65% of people develop lactose intolerance over time. However, there are other factors that might affect how likely you are to get this intolerance too. For most food intolerances, the causes seem to be a combination of genetic influence, natural exposure to certain substances over time, and countless other factors. Today, researchers still aren’t sure where some intolerances come from. In some circumstances, you’re born with a condition that affects the way you process certain foods. In other situations, you may develop a food intolerance over time, particularly if your body is exposed to other conditions like IBS, gut problems, and immune system issues.
  • #42 What Causes Food Intolerances? A Comprehensive Guide – Healthpath
    https://healthpath.com/gut-health/what-causes-food-intolerances/
    Dysbiosis compromises your gut immunity and digestive power, and increases your chances of leaky gut (which has in fact been linked in research to food intolerances and allergies). […] The use of pesticides and food additives could mean that your body gets confused between the chemicals and the foods theyre used with. […] Many people suggest that our bodies cannot recognise the altered proteins in genetically modified or processed food. […] Our nutrient-poor, calorie-dense diets compromise our immune systems. Poor diets are the leading cause of immunodeficiency worldwide. […] However, we do know which foods or components of foods, to be more precise, are most likely to give you your symptoms. […] Many experts believe that food intolerances are at least partly caused by poor gut health and changes in your microbiome, brought on by illness, medications or pregnancy, for example.
  • #43 What Causes Food Intolerances? A Comprehensive Guide – Healthpath
    https://healthpath.com/gut-health/what-causes-food-intolerances/
    Dysbiosis compromises your gut immunity and digestive power, and increases your chances of leaky gut (which has in fact been linked in research to food intolerances and allergies). […] The use of pesticides and food additives could mean that your body gets confused between the chemicals and the foods theyre used with. […] Many people suggest that our bodies cannot recognise the altered proteins in genetically modified or processed food. […] Our nutrient-poor, calorie-dense diets compromise our immune systems. Poor diets are the leading cause of immunodeficiency worldwide. […] However, we do know which foods or components of foods, to be more precise, are most likely to give you your symptoms. […] Many experts believe that food intolerances are at least partly caused by poor gut health and changes in your microbiome, brought on by illness, medications or pregnancy, for example.
  • #44 Food Intolerance | Children’s Hospital of Philadelphia
    https://www.chop.edu/conditions-diseases/food-intolerance
    People have a food intolerance when they have difficulty digesting certain foods and have an unpleasant physical reaction when they eat those foods. […] Food intolerances and food allergies are caused by different biological processes and are diagnosed and treated differently. The problem in food intolerance lies in the digestive system, not in the immune system as in food allergies, though the symptoms of the two types of food reactions can be similar. […] Food intolerance may be caused by: Lack of an enzyme needed to digest a certain food, or insufficient enzymes to digest a food fully. […] Sensitivity to certain chemicals in food. […] Irritable bowel syndrome (IBS). This chronic condition causes annoying and often painful abdominal and bowel symptoms, sometimes in reaction to eating particular foods. […] Psychological factors. For some people, certain foods can cause nausea and other digestive problems for psychological reasons.
  • #45
    https://www.everlywell.com/blog/food-sensitivity/what-are-the-causes-of-food-intolerance/?srsltid=AfmBOorpwd4C78tZXMp-kwzTnFhsFA6pcq0w8siuInf47BJst3HpJq2u
    Food intolerances are any adverse reaction you experience after eating certain foods. […] Food intolerances can be caused by a variety of reasons, including but not limited to: […] Irritable bowel syndrome is a common gastrointestinal disorder that affects many people around the world. IBS can be uncomfortable to live with and can be triggered by certain food intake. […] Psychological well-being can affect overall health and the state of the digestive system. This can lead to questioning if someone has food intolerances when, in actuality, psychological distress and/or stress may be the culprit of exacerbating stomach issues. […] In the research surrounding food intolerances and genetics, there is still much to be discovered. […] If you are experiencing food intolerances, you may wonder if your environment and/or lifestyle contribute.
  • #46 Sudden Food Intolerances in Adults (and Possible Causes) – JJ Virgin
    https://jjvirgin.com/sudden-food-intolerances-in-adults-and-possible-causes/
    Research shows the stress response can alter the natural balance of healthy bacteria in your gut, causing the gut ecology to shift in favor of a more hostile group of bacteria. […] Other studies show that stress and mood disorders such as depression compound each other and contribute to leaky gut and dysbiosis, creating an inflammatory response that starts in your gut, but like wildfire, spreads throughout your body. […] While new food intolerances may seem to come on suddenly, their development is a gradual process.
  • #47 The 8 Most Common Food Intolerances
    https://www.healthline.com/nutrition/common-food-intolerances
    Food intolerances are commonly diagnosed by elimination diets specifically designed to narrow down offending foods or through other testing methods. […] Lactose intolerance is caused by a shortage of lactase enzymes, which causes an inability to digest lactose and results in digestive symptoms. […] In fact, it is estimated that 65% of the world’s population has trouble digesting lactose. […] Non-celiac gluten sensitivity is a milder form of gluten intolerance that has been estimated to impact anywhere from 0.5 to 13% of the population. […] Symptoms of non-celiac gluten sensitivity are similar to those of celiac disease. […] Some people are more sensitive to caffeine and experience reactions even after consuming a small amount. […] Symptoms of salicylate intolerance include stuffy nose, sinus infections, nasal and sinus polyps, asthma, diarrhea, gut inflammation, and hives.
  • #48 Azthena logo with the word Azthena
    https://www.news-medical.net/health/Causes-of-Food-Intolerance.aspx
    Food intolerance is a functional or structural intolerance to food, which is non-immunologic and non-toxic in origin, but is chemically based instead. […] A third type of food intolerance involves the effects produced by pharmacologically active amines and other compounds present in foods. […] Thus, food intolerance describes a range of food-related symptoms that are not immunologically-mediated. These account for the majority of food reactions. […] Functional food intolerance is not associated with structural abnormalities of the digestive tract, but may be due to an isolated enzyme deficiency. […] A prime example of functional food intolerance is lactose intolerance. […] Carbohydrate intolerances involve the inability to digest and absorb sorbitol, fructose or other simple sugars.
  • #49 Azthena logo with the word Azthena
    https://www.news-medical.net/health/Causes-of-Food-Intolerance.aspx
    Lactase deficiency is the best known and is the cause of intolerance to milk and other dairy products, which contain lactose, also known as milk sugar. […] Other examples include the isolated or combined disaccharide malabsorption syndrome, which prevents the absorption of sucrose, lactose and other disaccharides, either one in particular or all together. […] When these sugars are not absorbed properly, they reach the large intestine in increased amounts, resulting in excessive fermentation and bacterial overgrowth. […] The production of osmotic sugars and their fermentation products in larger quantities causes symptoms, such as meteorism (i.e. the accumulation of excess gas in the gastrointestinal tract), flatulence and diarrhea. […] Diamine oxidase deficiency may cause histamine intolerance.
  • #50 What Causes Sudden Food Intolerance? – New Life Nutrition
    https://www.newlifenutrition.com.au/food-intolerances-and-allergies/what-causes-sudden-food-intolerance/
    Food intolerance also referred to as food sensitivity is a reaction of certain chemicals in your body to particular substances found in the foods you eat. […] Food intolerance may be hereditary and detected during childhood, but it can also emerge later in life. […] A sudden sensitivity to certain foods can also occur as a result of taking medications (e.g. antibiotics) for a considerable time or due to a stressful life event like losing your job, going through a breakup or divorce, undergoing major surgery or battling a serious illness. […] If your body reacts negatively to foods that contain FODMAPs, it may be due to its inability to produce the enzymes required to metabolise FODMAPs. […] Symptoms of lactose intolerance may suddenly appear as you grow older and your production of lactase declines.
  • #51 What Causes Food Intolerances? Can They Develop Over Time? – CircleDNA
    https://circledna.com/blog/causes-of-food-intolerance/?srsltid=AfmBOopCEnGKvlAU6jQH4cmIIJBUhUBAZOTo29xKa_HJLo_3bUCpAmrK
    Food intolerances are a common issue for many people, and the associated health problems can be quite severe. The question is, where do these food intolerances come from? Food intolerances aren’t the same as a food allergy, where consuming a problem food can be potentially life-threatening. With food intolerance or food sensitivity, you’re more likely to have negative side effects when you eat a certain kind of food. A food intolerance might be something you’re born with. Genes can sometimes lead to someone having a higher chance of intolerance. For instance, people of East Asian descent are more likely to have an inherited genetic mutation that causes alcohol intolerance. However, anyone can have the enzyme problem that causes this condition. Other kinds of food intolerance naturally progress over time. Look at lactose intolerance, for example. According to the National Institutes of Health, about 65% of people develop lactose intolerance over time. However, there are other factors that might affect how likely you are to get this intolerance too. For most food intolerances, the causes seem to be a combination of genetic influence, natural exposure to certain substances over time, and countless other factors. Today, researchers still aren’t sure where some intolerances come from. In some circumstances, you’re born with a condition that affects the way you process certain foods. In other situations, you may develop a food intolerance over time, particularly if your body is exposed to other conditions like IBS, gut problems, and immune system issues.
  • #52 Food intolerance: Causes, types, symptoms, and diagnosis
    https://www.medicalnewstoday.com/articles/263965
    Food intolerances arise if the body is unable to digest a certain food. This impairment may be due to a lack of digestive enzymes or a sensitivity to certain chemicals. […] Food intolerances are more common in those with digestive system disorders, such as irritable bowel syndrome (IBS). According to the IBS network, most people with IBS have food intolerances. […] Lactose is a sugar that occurs in milk. People with lactose intolerance do not have enough lactase, an enzyme that breaks lactose into smaller molecules that the body can easily absorb through the intestine. […] Fructose is a sugar present in fruit, some vegetables, and honey. Although rare, fructose intolerance can also be due to the lack of an enzyme known as hereditary fructose intolerance. […] Gluten intolerance is also known as nonceliac gluten sensitivity. […] Food intolerances arise when the body cannot properly digest certain foods.
  • #53 Food allergy – Symptoms and causes – Mayo Clinic
    https://www.mayoclinic.org/diseases-conditions/food-allergy/symptoms-causes/syc-20355095
    Celiac disease. While celiac disease is sometimes referred to as a gluten allergy, it does not result in anaphylaxis. Like a food allergy, celiac disease does involve an immune system response, but it’s a unique reaction that’s more complex than a simple food allergy. This ongoing digestive condition is triggered by eating gluten, a protein found in bread, pasta, cookies and many other foods containing wheat, barley or rye. If you have celiac disease and eat foods containing gluten, an immune reaction happens that causes damage to the surface of your small intestine. This leads to an inability to absorb certain nutrients.
  • #54 Food Intolerances
    https://pmc.ncbi.nlm.nih.gov/articles/PMC6682924/
    The definition of food intolerance is a non-immunological response initiated by a food or food component at a dose normally tolerated and account for most adverse food responses. […] This is further complicated by the various mechanisms of food intolerance that can exist, ranging from pharmacological (e.g. caffeine), to enzyme deficiencies (e.g. lactose malabsorption), to non-specific gastrointestinal (GI) functioning. […] The two parts of wheat relevant for discussion for food intolerance are the protein and carbohydrate fractions. […] Despite frequent self-diagnosis of NCG/WS, reproducibility of these symptoms is limited following a process of double-blind, placebo-controlled (DBPC) challenges. […] Due to the lack of reproducibility in clinical response, the mechanisms by which gluten causes symptoms within the food intolerance setting have been difficult to conclusively understand.
  • #55 Food allergy or food intolerance? A Q&A for parents – UChicago Medicine
    https://www.uchicagomedicine.org/forefront/gastrointestinal-articles/2023/january/food-allergies-vs-food-intolerance
    Another common sensitivity is gluten intolerance. Researchers are still unsure whether gluten causes this intolerance, but certain components of foods (such as wheat) that contain gluten may increase your intestines permeability. This means that microbes can cross the intestinal barrier and interact with the immune system, triggering a mild inflammatory reaction along with symptoms like abdominal pain, diarrhea and bloating.
  • #56 Food Intolerances
    https://pmc.ncbi.nlm.nih.gov/articles/PMC6682924/
    The definition of food intolerance is a non-immunological response initiated by a food or food component at a dose normally tolerated and account for most adverse food responses. […] This is further complicated by the various mechanisms of food intolerance that can exist, ranging from pharmacological (e.g. caffeine), to enzyme deficiencies (e.g. lactose malabsorption), to non-specific gastrointestinal (GI) functioning. […] The two parts of wheat relevant for discussion for food intolerance are the protein and carbohydrate fractions. […] Despite frequent self-diagnosis of NCG/WS, reproducibility of these symptoms is limited following a process of double-blind, placebo-controlled (DBPC) challenges. […] Due to the lack of reproducibility in clinical response, the mechanisms by which gluten causes symptoms within the food intolerance setting have been difficult to conclusively understand.
  • #57 Food Intolerances
    https://pmc.ncbi.nlm.nih.gov/articles/PMC6682924/
    The evidence for mechanisms of ATIs remains in its infancy. […] The heterogeneity of results combined with consistent evidence indicative of the overlap between IBS and gluten-related disorders and high placebo and nocebo responses means elucidating the underlying mechanisms of true wheat or gluten intolerance requires much more data. […] Histamine intolerance results from an imbalance of accumulated or ingested histamine and the reduced ability to degrade histamine. […] Histamine produced in the body seems to have less effect on histamine intolerance, except in situations such as mastocytosis with an increased number of mast cells or the so-called mast cell activation syndrome (MCAS). […] There are no validated diagnostic biomarkers, the definition according to the scientific literature for NCG/WS is where subjects are responsive to a gluten-free diet and react to re-challenge with gluten compared to placebo.
  • #58 Azthena logo with the word Azthena
    https://www.news-medical.net/health/Causes-of-Food-Intolerance.aspx
    Lactase deficiency is the best known and is the cause of intolerance to milk and other dairy products, which contain lactose, also known as milk sugar. […] Other examples include the isolated or combined disaccharide malabsorption syndrome, which prevents the absorption of sucrose, lactose and other disaccharides, either one in particular or all together. […] When these sugars are not absorbed properly, they reach the large intestine in increased amounts, resulting in excessive fermentation and bacterial overgrowth. […] The production of osmotic sugars and their fermentation products in larger quantities causes symptoms, such as meteorism (i.e. the accumulation of excess gas in the gastrointestinal tract), flatulence and diarrhea. […] Diamine oxidase deficiency may cause histamine intolerance.
  • #59 Food Intolerances
    https://pmc.ncbi.nlm.nih.gov/articles/PMC6682924/
    The evidence for mechanisms of ATIs remains in its infancy. […] The heterogeneity of results combined with consistent evidence indicative of the overlap between IBS and gluten-related disorders and high placebo and nocebo responses means elucidating the underlying mechanisms of true wheat or gluten intolerance requires much more data. […] Histamine intolerance results from an imbalance of accumulated or ingested histamine and the reduced ability to degrade histamine. […] Histamine produced in the body seems to have less effect on histamine intolerance, except in situations such as mastocytosis with an increased number of mast cells or the so-called mast cell activation syndrome (MCAS). […] There are no validated diagnostic biomarkers, the definition according to the scientific literature for NCG/WS is where subjects are responsive to a gluten-free diet and react to re-challenge with gluten compared to placebo.
  • #60 The 8 Most Common Food Intolerances
    https://www.healthline.com/nutrition/common-food-intolerances
    The most common reason for histamine intolerance is impaired function of the enzymes responsible for breaking down histamine. […] Symptoms of histamine intolerance include flushing of the skin, headaches, hives, itching, anxiety, stomach cramps, diarrhea, and low blood pressure. […] FODMAP intolerances are very common in people with irritable bowel syndrome, or IBS. […] Symptoms of a FODMAP intolerance include bloating, diarrhea, gas, abdominal pain, and constipation. […] People who are intolerant to sulfites can experience symptoms like stuffy nose, wheezing, and low blood pressure. […] In people with fructose intolerance, fructose isn’t efficiently absorbed into the blood. […] Symptoms of fructose malabsorption include reflux, gas, diarrhea, nausea, abdominal pain, vomiting, and bloating. […] Food intolerances differ from allergies. Most do not trigger the immune system, and their symptoms are usually less severe. […] Many people are intolerant or hypersensitive to foods and additives like dairy products, caffeine, and gluten.
  • #61 Food Intolerance Causes Types and Diagnosis – HealthcareOnTime
    https://www.healthcareontime.com/health-tips/food-intolerance-causes-types-and-diagnosis/?srsltid=AfmBOoq7Xh5P3Jc7wlPDD-7jM30qII4qk7iCG0imxjgKXI1kXK3UQDZ8
    The most common example of enzymatic defect is lactose intolerance. It arises due to the deficiency of the enzyme beta-galactosidase that aids in the hydrolysis of lactose into two monosaccharides making them easily available to body. […] High levels of histamine are found in fish, two other diamines produced in spoiled fish are- putrescine and cadaverine. They are responsible for hindering the DAO activity followed by histaminic effect like erythema vasodilation tachycardia, hypertension, migraine, vomiting and diarrhea. […] Food may even contain toxins of the bacterial or plant origin that provoke intolerance symptoms. […] Intolerance due to food additive reactions can be termed as undefined intolerance. Generally, additives used in food production are limited to their legal dosage, and are Generally Recognized as safe (GRAS) products.
  • #62 Food Intolerance – Causes Symptoms Diagnosis Treatment Prevention
    https://www.medindia.net/health/conditions/food-intolerance.htm
    Food intolerance can be due to various foods. […] Common food intolerances include the following: Dairy and dairy products – Lactose (a sugar found in milk) intolerance (due to lactase enzyme deficiency which is needed to digest lactose). […] Gluten – General term for proteins found in wheat, barley, rye, and triticale. […] Caffeine – A bitter chemical found in certain beverages such as tea, coffee, soda, and energy drinks. […] Salicylates – A natural chemical found in certain foods such as tea, coffee, honey, fruits, vegetables, spice, and nuts. […] Amines – These are chemicals found in several foods and are produced on storage due to bacterial action and fermentation. […] FODMAPs – Stands for (fermentable oligo-, di-, mono-saccharides and polyols). […] Sulfites – These are chemicals found naturally occurring in certain foods such as grapes and aged cheese. […] Fructose – It is a simple sugar occurring in honey, high fructose corn syrup, certain fruits, and vegetables.
  • #63 The 8 Most Common Food Intolerances
    https://www.healthline.com/nutrition/common-food-intolerances
    The most common reason for histamine intolerance is impaired function of the enzymes responsible for breaking down histamine. […] Symptoms of histamine intolerance include flushing of the skin, headaches, hives, itching, anxiety, stomach cramps, diarrhea, and low blood pressure. […] FODMAP intolerances are very common in people with irritable bowel syndrome, or IBS. […] Symptoms of a FODMAP intolerance include bloating, diarrhea, gas, abdominal pain, and constipation. […] People who are intolerant to sulfites can experience symptoms like stuffy nose, wheezing, and low blood pressure. […] In people with fructose intolerance, fructose isn’t efficiently absorbed into the blood. […] Symptoms of fructose malabsorption include reflux, gas, diarrhea, nausea, abdominal pain, vomiting, and bloating. […] Food intolerances differ from allergies. Most do not trigger the immune system, and their symptoms are usually less severe. […] Many people are intolerant or hypersensitive to foods and additives like dairy products, caffeine, and gluten.
  • #64
    https://cz.macromo.com/en/blogs/articles/food-intolerance-what-causes-it
    FODMAPs are not absorbed in the small intestine to any significant degree, and so they travel to the large intestine. […] Fructose intolerance can be inborn, or acquired by intestinal damage, diabetes, celiac disease or Crohn disease. […] Food intolerances are, unlike food allergies, not life-threatening and not mediated by the immune system.
  • #65 Food Intolerance – Causes Symptoms Diagnosis Treatment Prevention
    https://www.medindia.net/health/conditions/food-intolerance.htm
    Food intolerance can be due to various foods. […] Common food intolerances include the following: Dairy and dairy products – Lactose (a sugar found in milk) intolerance (due to lactase enzyme deficiency which is needed to digest lactose). […] Gluten – General term for proteins found in wheat, barley, rye, and triticale. […] Caffeine – A bitter chemical found in certain beverages such as tea, coffee, soda, and energy drinks. […] Salicylates – A natural chemical found in certain foods such as tea, coffee, honey, fruits, vegetables, spice, and nuts. […] Amines – These are chemicals found in several foods and are produced on storage due to bacterial action and fermentation. […] FODMAPs – Stands for (fermentable oligo-, di-, mono-saccharides and polyols). […] Sulfites – These are chemicals found naturally occurring in certain foods such as grapes and aged cheese. […] Fructose – It is a simple sugar occurring in honey, high fructose corn syrup, certain fruits, and vegetables.
  • #66 Food intolerance: Causes, types, symptoms, and diagnosis
    https://www.medicalnewstoday.com/articles/263965
    Food intolerances arise if the body is unable to digest a certain food. This impairment may be due to a lack of digestive enzymes or a sensitivity to certain chemicals. […] Food intolerances are more common in those with digestive system disorders, such as irritable bowel syndrome (IBS). According to the IBS network, most people with IBS have food intolerances. […] Lactose is a sugar that occurs in milk. People with lactose intolerance do not have enough lactase, an enzyme that breaks lactose into smaller molecules that the body can easily absorb through the intestine. […] Fructose is a sugar present in fruit, some vegetables, and honey. Although rare, fructose intolerance can also be due to the lack of an enzyme known as hereditary fructose intolerance. […] Gluten intolerance is also known as nonceliac gluten sensitivity. […] Food intolerances arise when the body cannot properly digest certain foods.
  • #67 Azthena logo with the word Azthena
    https://www.news-medical.net/health/Causes-of-Food-Intolerance.aspx
    Other than enzyme deficiencies, transporter molecule defects may be present. […] These include defects in GLUT 5, which transports fructose, or GLUT 2 for glucose, galactose or fructose. […] The inability to transport these carbohydrates into the intestinal cells results in their metabolism in the large intestine where they are transported intact in large quantities. […] Patients who are at risk for bacterial overgrowth include those who have been surgically treated by bowel resection, or are on chronic treatment with proton pump inhibitors, such as ranitidine or omeprazole. […] This leads to symptoms of food intolerance following ingestion of a number of foods, due to the release of excessive bacterial decomposition products in the gut. […] Many foods contain compounds with intrinsic biologic activity, such as salicylates, biogenic amines, and other substances that may lead to intolerance due to enzyme deficiencies.
  • #68 The 8 Most Common Food Intolerances
    https://www.healthline.com/nutrition/common-food-intolerances
    The most common reason for histamine intolerance is impaired function of the enzymes responsible for breaking down histamine. […] Symptoms of histamine intolerance include flushing of the skin, headaches, hives, itching, anxiety, stomach cramps, diarrhea, and low blood pressure. […] FODMAP intolerances are very common in people with irritable bowel syndrome, or IBS. […] Symptoms of a FODMAP intolerance include bloating, diarrhea, gas, abdominal pain, and constipation. […] People who are intolerant to sulfites can experience symptoms like stuffy nose, wheezing, and low blood pressure. […] In people with fructose intolerance, fructose isn’t efficiently absorbed into the blood. […] Symptoms of fructose malabsorption include reflux, gas, diarrhea, nausea, abdominal pain, vomiting, and bloating. […] Food intolerances differ from allergies. Most do not trigger the immune system, and their symptoms are usually less severe. […] Many people are intolerant or hypersensitive to foods and additives like dairy products, caffeine, and gluten.
  • #69
    https://cz.macromo.com/en/blogs/articles/food-intolerance-what-causes-it
    FODMAPs are not absorbed in the small intestine to any significant degree, and so they travel to the large intestine. […] Fructose intolerance can be inborn, or acquired by intestinal damage, diabetes, celiac disease or Crohn disease. […] Food intolerances are, unlike food allergies, not life-threatening and not mediated by the immune system.
  • #70 Food intolerance: Causes, types, symptoms, and diagnosis
    https://www.medicalnewstoday.com/articles/263965
    Food intolerances arise if the body is unable to digest a certain food. This impairment may be due to a lack of digestive enzymes or a sensitivity to certain chemicals. […] Food intolerances are more common in those with digestive system disorders, such as irritable bowel syndrome (IBS). According to the IBS network, most people with IBS have food intolerances. […] Lactose is a sugar that occurs in milk. People with lactose intolerance do not have enough lactase, an enzyme that breaks lactose into smaller molecules that the body can easily absorb through the intestine. […] Fructose is a sugar present in fruit, some vegetables, and honey. Although rare, fructose intolerance can also be due to the lack of an enzyme known as hereditary fructose intolerance. […] Gluten intolerance is also known as nonceliac gluten sensitivity. […] Food intolerances arise when the body cannot properly digest certain foods.
  • #71 Food Intolerance | Children’s Hospital of Philadelphia
    https://www.chop.edu/conditions-diseases/food-intolerance
    People have a food intolerance when they have difficulty digesting certain foods and have an unpleasant physical reaction when they eat those foods. […] Food intolerances and food allergies are caused by different biological processes and are diagnosed and treated differently. The problem in food intolerance lies in the digestive system, not in the immune system as in food allergies, though the symptoms of the two types of food reactions can be similar. […] Food intolerance may be caused by: Lack of an enzyme needed to digest a certain food, or insufficient enzymes to digest a food fully. […] Sensitivity to certain chemicals in food. […] Irritable bowel syndrome (IBS). This chronic condition causes annoying and often painful abdominal and bowel symptoms, sometimes in reaction to eating particular foods. […] Psychological factors. For some people, certain foods can cause nausea and other digestive problems for psychological reasons.
  • #72 The 8 Most Common Food Intolerances
    https://www.healthline.com/nutrition/common-food-intolerances
    The most common reason for histamine intolerance is impaired function of the enzymes responsible for breaking down histamine. […] Symptoms of histamine intolerance include flushing of the skin, headaches, hives, itching, anxiety, stomach cramps, diarrhea, and low blood pressure. […] FODMAP intolerances are very common in people with irritable bowel syndrome, or IBS. […] Symptoms of a FODMAP intolerance include bloating, diarrhea, gas, abdominal pain, and constipation. […] People who are intolerant to sulfites can experience symptoms like stuffy nose, wheezing, and low blood pressure. […] In people with fructose intolerance, fructose isn’t efficiently absorbed into the blood. […] Symptoms of fructose malabsorption include reflux, gas, diarrhea, nausea, abdominal pain, vomiting, and bloating. […] Food intolerances differ from allergies. Most do not trigger the immune system, and their symptoms are usually less severe. […] Many people are intolerant or hypersensitive to foods and additives like dairy products, caffeine, and gluten.
  • #73 FOOD SENSITIVITIES AND INTOLERANCE: FROM TRIGGERS TO TREATMENT (PT. 1) | Mya Care
    https://myacare.com/blog/food-sensitivities-and-intolerance-from-triggers-to-treatment-pt-1
    Loss of oral tolerance has been linked to increased intestinal permeability and heightened immune reactivity towards antigens. […] The reactivity of the immune system can facilitate a loss of oral tolerance to a specific antigen. […] Gut dysbiosis refers to a chronic imbalance in the microbial ecology of the gut, which has been linked to the perpetuation of food sensitivities, intolerances, and allergies. […] It is common for those with chronic food sensitivities to be sensitive to multiple types of food that share a common molecular overlap. […] Food sensitivities and intolerances are generally associated with elevations in IgG antibodies, which is often how they are also tested for. […] Specific genetic alleles can predispose individuals to allergies and sensitivities by promoting increased gut permeability and reduced IgA production.
  • #74 Food Intolerance: Symptoms, Causes and Treatment Options
    https://my.clevelandclinic.org/health/diseases/21688-food-intolerance
    Food intolerance means your gut is sensitive to certain foods and cant tolerate them. […] People with food intolerances often dont make enough of a particular enzyme that the digestive system needs to break down a certain food or ingredient. Experts arent sure why some people develop food intolerances. […] Certain gastrointestinal conditions may make you more prone to food sensitivities. These conditions include: Celiac disease. Inflammatory bowel disease (IBD), including Crohns disease and ulcerative colitis.
  • #75 Azthena logo with the word Azthena
    https://www.news-medical.net/health/Causes-of-Food-Intolerance.aspx
    Other than enzyme deficiencies, transporter molecule defects may be present. […] These include defects in GLUT 5, which transports fructose, or GLUT 2 for glucose, galactose or fructose. […] The inability to transport these carbohydrates into the intestinal cells results in their metabolism in the large intestine where they are transported intact in large quantities. […] Patients who are at risk for bacterial overgrowth include those who have been surgically treated by bowel resection, or are on chronic treatment with proton pump inhibitors, such as ranitidine or omeprazole. […] This leads to symptoms of food intolerance following ingestion of a number of foods, due to the release of excessive bacterial decomposition products in the gut. […] Many foods contain compounds with intrinsic biologic activity, such as salicylates, biogenic amines, and other substances that may lead to intolerance due to enzyme deficiencies.
  • #76 Food allergy – Symptoms and causes – Mayo Clinic
    https://www.mayoclinic.org/diseases-conditions/food-allergy/symptoms-causes/syc-20355095
    Celiac disease. While celiac disease is sometimes referred to as a gluten allergy, it does not result in anaphylaxis. Like a food allergy, celiac disease does involve an immune system response, but it’s a unique reaction that’s more complex than a simple food allergy. This ongoing digestive condition is triggered by eating gluten, a protein found in bread, pasta, cookies and many other foods containing wheat, barley or rye. If you have celiac disease and eat foods containing gluten, an immune reaction happens that causes damage to the surface of your small intestine. This leads to an inability to absorb certain nutrients.
  • #77 Food intolerance – Australasian Society of Clinical Immunology and Allergy (ASCIA)
    https://www.allergy.org.au/patients/food-other-adverse-reactions/food-intolerance
    Temporary elimination diet: the only reliable way to determine if diet is playing a role is being placed on a temporary elimination diet, under the supervision of a dietitian and medical practitioner. […] Coeliac disease is not an allergy but does involve an immune system response to foods containing gluten. […] Non-coeliac gluten intolerance is a recently recognised condition which can cause symptoms such as abdominal disturbance (usually bloating but sometimes other symptoms as well), and occasionally discomfort and tiredness.
  • #78 5 things that could be causing your food intolerance
    https://allergytest-london.co.uk/2016/08/09/5-things-that-could-be-causing-your-food-intolerances/
    Many of us experience food intolerances (non-allergic food hypersensitivity) that result in difficulty digesting a particular type of food. […] Food intolerances can be caused by several different things. […] The British Allergy Foundation identifies enzyme deficiencies as a common cause of food intolerances. […] Studies have shown that individuals with liver disease are four to six times more likely to develop an intolerance to gluten, and Celiac disease (the autoimmune reaction to dietary gluten). […] This clearly links an intolerance to gluten with the development of liver disease, and vice versa. […] Sensitivity to histamine is quite common. […] Leaky gut (intestinal permeability) is a common cause of food intolerances. […] Leaky gut is extremely common and causes heartburn, wind, bloating, pain, constipation, and diarrhoea. […] Your food intolerances could also be caused by parasites infecting your intestines.
  • #79 The Differential Diagnosis of Food Intolerance
    https://pmc.ncbi.nlm.nih.gov/articles/PMC2695393/
    The pathogenesis of salicylate intolerance is based on an inhibition of cyclooxygenase-1 by salicylates and other non-steroidal pain medications, but also by salicylate-containing foods and other acids (such as benzoic acid or colorants) resulting in reduced prostaglandin synthesis. […] The symptoms of histamine intolerance are highly variable and affect almost all organs. […] The symptoms resemble those of the underlying diseases, most likely histamine intolerance or food allergy. […] The diagnosis has to be confirmed by a histological analysis of tissue (skin, gastrointestinal tract) or bone marrow biopsy to demonstrate mast cell infiltration. […] The symptoms of systemic mastocytosis can include not only cutaneous signs but also episodic gastrointestinal complaints such as nausea, burning abdominal pain, diarrhea, ulcer diseases, gastrointestinal bleeding and malabsorption.
  • #80 The Differential Diagnosis of Food Intolerance
    https://pmc.ncbi.nlm.nih.gov/articles/PMC2695393/
    The pathogenesis of salicylate intolerance is based on an inhibition of cyclooxygenase-1 by salicylates and other non-steroidal pain medications, but also by salicylate-containing foods and other acids (such as benzoic acid or colorants) resulting in reduced prostaglandin synthesis. […] The symptoms of histamine intolerance are highly variable and affect almost all organs. […] The symptoms resemble those of the underlying diseases, most likely histamine intolerance or food allergy. […] The diagnosis has to be confirmed by a histological analysis of tissue (skin, gastrointestinal tract) or bone marrow biopsy to demonstrate mast cell infiltration. […] The symptoms of systemic mastocytosis can include not only cutaneous signs but also episodic gastrointestinal complaints such as nausea, burning abdominal pain, diarrhea, ulcer diseases, gastrointestinal bleeding and malabsorption.
  • #81 The Differential Diagnosis of Food Intolerance
    https://pmc.ncbi.nlm.nih.gov/articles/PMC2695393/
    The pathogenesis of systemic mastocytosis is based mainly on a mutation of transmembrane c-kit receptor tyrosine kinase, which is responsible for the proliferation and maturation of mast cells. […] The most important therapeutic measures are avoiding the known trigger factors, mast cell stabilization, reducing mast cell growth, and antagonizing secreted mediators.
  • #82 Inflammatory symptoms, immune system and food intolerance: One cause – many symptoms – Alcat Education
    https://cellsciencesystems.com/education/research/inflammatory-symptoms-immune-system-and-food-intolerance-one-cause-many-symptoms/
    Inflammatory diseases and degenerative processes have greatly increased in the last decades and parallel the industrialization of food and modern life style. […] An important cause may be food intolerance, which is mediated by the innate immune system. It leads to typical adverse reactions and inflammatory processes. […] Various influences, which the immune system is exposed, can decide between “alien / dangerous” and “self / harmless” disrupt and normally harmless dietary components put an immune reaction. […] Food intolerance mediated by the innate immune response happens often. Specific pattern recognition receptors in the cell membrane of immune cells initiate the release of an inflammatory cascade. […] The consequences of food-induced activation of the immune system can initially be subtle, but may become serious over time.
  • #83 What Causes Food Intolerances? A Comprehensive Guide – Healthpath
    https://healthpath.com/gut-health/what-causes-food-intolerances/
    Dysbiosis compromises your gut immunity and digestive power, and increases your chances of leaky gut (which has in fact been linked in research to food intolerances and allergies). […] The use of pesticides and food additives could mean that your body gets confused between the chemicals and the foods theyre used with. […] Many people suggest that our bodies cannot recognise the altered proteins in genetically modified or processed food. […] Our nutrient-poor, calorie-dense diets compromise our immune systems. Poor diets are the leading cause of immunodeficiency worldwide. […] However, we do know which foods or components of foods, to be more precise, are most likely to give you your symptoms. […] Many experts believe that food intolerances are at least partly caused by poor gut health and changes in your microbiome, brought on by illness, medications or pregnancy, for example.
  • #84 Food Intolerance / Non-allergic Food Hypersensitivity | The Burghwood Clinic
    https://www.burghwoodclinic.co.uk/clinical/conditions/food-intolerance-non-allergic-food-hypersensitivity
    The concept of food intolerance, like other types of immune reactivity, is complex because it is responsible for many modern-day conditions and ill health. […] The most common culprits are usually frequently eaten foods, such as grains, dairy, chicken, egg, tea, coffee, chocolate, sugar, citrus fruits, yeast, potato, onion, alcoholic beverages and food additives. […] The repetitive use of some common foods and the extensive use of chemicals, such as pesticides and additives, colourings, preservatives and flavourings, has increased the risk to develop intolerance. […] The immune system often reduces the severity of symptoms, as a result of frequent use of various foods. […] Food intolerance involves a number of foods causing a variety of symptoms in different individuals. […] Food intolerance can be reversed, i.e some people can start tolerating some foods following long term avoidance or a careful adjustment of their diet.
  • #85 The Root Cause Of Food Sensitivities | Dr. Brian Lum
    https://www.drbrianlum.com/food-sensitivities
    Many of these well-informed patients with meticulously healthy diets have hidden food intolerances (also called sensitivities) that secretly sabotage their health. […] Food intolerances can cause painful and debilitating symptoms. […] Food intolerance can cause severe symptoms and the lack of an antibody (which would classify their reaction as an allergy) is no reason not to take this condition seriously. […] Food sensitivities, particularly multiple food sensitivities (to gluten, soy, eggs, dairy, etc.) are, in the vast majority of cases a sign that your body’s ability to function is compromised. […] To fix the reason why you are having a food intolerance in the first place requires treatment of the underlying biochemical issue that caused you to become reactive to foods. […] The second step is to correct an immune imbalance – there is a reason why your immune system is launching a response against a formerly harmless food.
  • #86 What Causes Food Intolerances? A Comprehensive Guide – Healthpath
    https://healthpath.com/gut-health/what-causes-food-intolerances/
    Dysbiosis compromises your gut immunity and digestive power, and increases your chances of leaky gut (which has in fact been linked in research to food intolerances and allergies). […] The use of pesticides and food additives could mean that your body gets confused between the chemicals and the foods theyre used with. […] Many people suggest that our bodies cannot recognise the altered proteins in genetically modified or processed food. […] Our nutrient-poor, calorie-dense diets compromise our immune systems. Poor diets are the leading cause of immunodeficiency worldwide. […] However, we do know which foods or components of foods, to be more precise, are most likely to give you your symptoms. […] Many experts believe that food intolerances are at least partly caused by poor gut health and changes in your microbiome, brought on by illness, medications or pregnancy, for example.
  • #87 What Causes Food Intolerances? A Comprehensive Guide – Healthpath
    https://healthpath.com/gut-health/what-causes-food-intolerances/
    Dysbiosis compromises your gut immunity and digestive power, and increases your chances of leaky gut (which has in fact been linked in research to food intolerances and allergies). […] The use of pesticides and food additives could mean that your body gets confused between the chemicals and the foods theyre used with. […] Many people suggest that our bodies cannot recognise the altered proteins in genetically modified or processed food. […] Our nutrient-poor, calorie-dense diets compromise our immune systems. Poor diets are the leading cause of immunodeficiency worldwide. […] However, we do know which foods or components of foods, to be more precise, are most likely to give you your symptoms. […] Many experts believe that food intolerances are at least partly caused by poor gut health and changes in your microbiome, brought on by illness, medications or pregnancy, for example.
  • #88 Causes Food Intolerances | Difference Between Food Allergy & Food Intolerance
    https://www.soulfoodshonali.com/blog/food-allergies/
    Food allergies is a response of the immune system to any foods that may not suit you. […] Causes for food intolerances include lacking an enzyme to digest the food; in the case of dairy the enzyme you may not have is lactase. Most people stop making this enzyme after the age of 4. […] Irritable bowel syndrome inflammation in the gut could lead to some food intolerances, e.g., gluten intolerance (celiac disease). […] Stress could also trigger a response to not digesting some foods. […] Some medication could make your gut very weak and cause a food intolerance; e.g., prolonged use of pain medication could throw off your gut and make you less tolerant of leafy greens or raw foods. […] Food allergies are also on the rise due to an influx of processed and packaged foods that carry a host of additives, colourings and synthetic chemicals.
  • #89 What Causes Food Allergies? | MyFoodAllergyTeam
    https://www.myfoodallergyteam.com/resources/what-causes-food-allergies
    Food allergies develop when the immune system mistakenly identifies a specific food protein as a dangerous invader. Symptoms of food allergies are caused by the immune systems inflammatory attack on the food protein. […] Most scientists believe food allergies are probably caused by a combination of inherited and environmental factors. Still, no one has identified why some people develop food allergies and some people dont. […] Many risk factors for food allergies have been identified and are being studied, but none have been pinpointed as the cause of food allergies. […] One theory suggests that the increase in food allergies in the modern era is caused by disruption in the balance of microorganisms that colonize the gut. […] Perhaps this lifestyle has triggered changes in our gut bacteria that has led to greater food intolerance. […] Another theory under consideration links low levels of vitamin D, including sunlight, with an increased risk for developing food allergies.
  • #90 What Causes Food Allergies? | MyFoodAllergyTeam
    https://www.myfoodallergyteam.com/resources/what-causes-food-allergies
    Food allergies develop when the immune system mistakenly identifies a specific food protein as a dangerous invader. Symptoms of food allergies are caused by the immune systems inflammatory attack on the food protein. […] Most scientists believe food allergies are probably caused by a combination of inherited and environmental factors. Still, no one has identified why some people develop food allergies and some people dont. […] Many risk factors for food allergies have been identified and are being studied, but none have been pinpointed as the cause of food allergies. […] One theory suggests that the increase in food allergies in the modern era is caused by disruption in the balance of microorganisms that colonize the gut. […] Perhaps this lifestyle has triggered changes in our gut bacteria that has led to greater food intolerance. […] Another theory under consideration links low levels of vitamin D, including sunlight, with an increased risk for developing food allergies.
  • #91 Food allergy | NHS inform
    https://www.nhsinform.scot/illnesses-and-conditions/nutritional/food-allergy/
    Food allergies happen when the immune system the bodys defence against infection mistakenly treats proteins found in food as a threat. […] A food allergy is caused by your immune system handling harmless proteins in certain foods as a threat. It releases a number of chemicals, which trigger an allergic reaction. […] Exactly what causes the immune system to mistake harmless proteins as a threat is unclear. However, a number of risk factors for food allergies have been identified, which are outlined below. […] The number of people with food allergies has risen sharply over the past few decades and, although the reason is unclear, other allergic conditions such as atopic dermatitis have also increased. […] Another theory is that children are increasingly growing up in germ-free environments. This means their immune systems may not receive sufficient early exposure to the germs needed to develop properly. This is known as the hygiene hypothesis.
  • #92
    https://www.everlywell.com/blog/food-sensitivity/what-are-the-causes-of-food-intolerance/?srsltid=AfmBOorpwd4C78tZXMp-kwzTnFhsFA6pcq0w8siuInf47BJst3HpJq2u
    Food intolerances are any adverse reaction you experience after eating certain foods. […] Food intolerances can be caused by a variety of reasons, including but not limited to: […] Irritable bowel syndrome is a common gastrointestinal disorder that affects many people around the world. IBS can be uncomfortable to live with and can be triggered by certain food intake. […] Psychological well-being can affect overall health and the state of the digestive system. This can lead to questioning if someone has food intolerances when, in actuality, psychological distress and/or stress may be the culprit of exacerbating stomach issues. […] In the research surrounding food intolerances and genetics, there is still much to be discovered. […] If you are experiencing food intolerances, you may wonder if your environment and/or lifestyle contribute.
  • #93 What Causes Sudden Food Intolerance? – New Life Nutrition
    https://www.newlifenutrition.com.au/food-intolerances-and-allergies/what-causes-sudden-food-intolerance/
    Food intolerance also referred to as food sensitivity is a reaction of certain chemicals in your body to particular substances found in the foods you eat. […] Food intolerance may be hereditary and detected during childhood, but it can also emerge later in life. […] A sudden sensitivity to certain foods can also occur as a result of taking medications (e.g. antibiotics) for a considerable time or due to a stressful life event like losing your job, going through a breakup or divorce, undergoing major surgery or battling a serious illness. […] If your body reacts negatively to foods that contain FODMAPs, it may be due to its inability to produce the enzymes required to metabolise FODMAPs. […] Symptoms of lactose intolerance may suddenly appear as you grow older and your production of lactase declines.
  • #94 Sudden Food Intolerances in Adults (and Possible Causes) – JJ Virgin
    https://jjvirgin.com/sudden-food-intolerances-in-adults-and-possible-causes/
    Research shows the stress response can alter the natural balance of healthy bacteria in your gut, causing the gut ecology to shift in favor of a more hostile group of bacteria. […] Other studies show that stress and mood disorders such as depression compound each other and contribute to leaky gut and dysbiosis, creating an inflammatory response that starts in your gut, but like wildfire, spreads throughout your body. […] While new food intolerances may seem to come on suddenly, their development is a gradual process.
  • #95 Sudden Food Intolerances in Adults (and Possible Causes) – JJ Virgin
    https://jjvirgin.com/sudden-food-intolerances-in-adults-and-possible-causes/
    Research shows the stress response can alter the natural balance of healthy bacteria in your gut, causing the gut ecology to shift in favor of a more hostile group of bacteria. […] Other studies show that stress and mood disorders such as depression compound each other and contribute to leaky gut and dysbiosis, creating an inflammatory response that starts in your gut, but like wildfire, spreads throughout your body. […] While new food intolerances may seem to come on suddenly, their development is a gradual process.
  • #96 Food Intolerance | Asthma & Allergy Center
    https://www.priyabansal.com/food-intolerance.php
    Food intolerance occurs when an individual has an adverse reaction to certain food or foods. Food intolerance is differentiated from food allergy because the former denotes a sensitivity, the latter a reaction of the immune system. […] There seem to be both genetic and environmental factors at play in the development of food intolerance. Since being intolerant to particular foods is more common in certain ethnic groups, there is clearly a genetic component to the condition. Reasons for food intolerance have not been wholly deciphered, however, though the following causes have been isolated: […] The causes of food intolerance may be difficult to assess, particularly if they have a psychological root. In such cases, when the affecting food is served in a disguised fashion it may be well-tolerated.
  • #97 Food Intolerances
    https://pmc.ncbi.nlm.nih.gov/articles/PMC6682924/
    Food intolerances are estimated to affect up to 20% of the population but complete understanding of diagnosis and management is complicated, given presentation and non-immunological mechanisms associated vary greatly. […] For many of the other food intolerances reviewed including non-coeliac gluten/wheat sensitivity, food additives and bioactive food chemicals, the findings show that there is a shortage of reproducible well-designed double-blind, placebo-controlled studies, making understanding of the mechanisms, diagnosis and management difficult. […] Enzyme deficiencies have been proposed to result in other food sensitivities including low amine oxidase activity resulting in histamine intolerance and sucrase-isomaltase deficiency resulting in reduced tolerance to sugars and starch. […] Lack of reliable diagnostic biomarkers for all food intolerances result in an inability to target specific foods in the individual.
  • #98 Food Intolerances
    https://pmc.ncbi.nlm.nih.gov/articles/PMC6682924/
    The evidence for mechanisms of ATIs remains in its infancy. […] The heterogeneity of results combined with consistent evidence indicative of the overlap between IBS and gluten-related disorders and high placebo and nocebo responses means elucidating the underlying mechanisms of true wheat or gluten intolerance requires much more data. […] Histamine intolerance results from an imbalance of accumulated or ingested histamine and the reduced ability to degrade histamine. […] Histamine produced in the body seems to have less effect on histamine intolerance, except in situations such as mastocytosis with an increased number of mast cells or the so-called mast cell activation syndrome (MCAS). […] There are no validated diagnostic biomarkers, the definition according to the scientific literature for NCG/WS is where subjects are responsive to a gluten-free diet and react to re-challenge with gluten compared to placebo.
  • #99 Food Intolerances
    https://pmc.ncbi.nlm.nih.gov/articles/PMC6682924/
    Given there are no validated diagnostic biomarkers, the definition according to the scientific literature for NCG/WS is where subjects are responsive to a gluten-free diet and react to re-challenge with gluten compared to placebo. […] There are no diagnostic tests available to assess food additive or chemical sensitivity.
  • #100 The 8 Most Common Food Intolerances
    https://www.healthline.com/nutrition/common-food-intolerances
    The most common reason for histamine intolerance is impaired function of the enzymes responsible for breaking down histamine. […] Symptoms of histamine intolerance include flushing of the skin, headaches, hives, itching, anxiety, stomach cramps, diarrhea, and low blood pressure. […] FODMAP intolerances are very common in people with irritable bowel syndrome, or IBS. […] Symptoms of a FODMAP intolerance include bloating, diarrhea, gas, abdominal pain, and constipation. […] People who are intolerant to sulfites can experience symptoms like stuffy nose, wheezing, and low blood pressure. […] In people with fructose intolerance, fructose isn’t efficiently absorbed into the blood. […] Symptoms of fructose malabsorption include reflux, gas, diarrhea, nausea, abdominal pain, vomiting, and bloating. […] Food intolerances differ from allergies. Most do not trigger the immune system, and their symptoms are usually less severe. […] Many people are intolerant or hypersensitive to foods and additives like dairy products, caffeine, and gluten.
  • #101 Food intolerance – Wikipedia
    https://en.wikipedia.org/wiki/Food_intolerance
    Pharmacological responses to naturally occurring compounds in food, or chemical intolerance, can occur in individuals from both allergic and non-allergic family backgrounds. Symptoms may begin at any age, and may develop quickly or slowly. […] Food intolerances can be caused by enzymatic defects in the digestive system, can also result from pharmacological effects of vasoactive amines present in foods (e.g. histamine), among other metabolic, pharmacological and digestive abnormalities.
  • #102 Food intolerance – Wikipedia
    https://en.wikipedia.org/wiki/Food_intolerance
    Food intolerances can be classified according to their mechanism. Intolerance can result from the absence of specific chemicals or enzymes needed to digest a food substance, as in hereditary fructose intolerance. […] A deficiency in digestive enzymes can also cause some types of food intolerances. Lactose intolerance is a result of the body not producing sufficient lactase to digest the lactose in milk; dairy foods which are lower in lactose, such as cheese, are less likely to trigger a reaction in this case. […] Reactions to chemical components of the diet may be more common than true food allergies, although there is no evidence to support this. They are caused by various organic chemicals occurring naturally in a wide variety of foods, animal and vegetable, more often than to food additives, preservatives, colourings and flavourings, such as sulfites or dyes.
  • #103 Azthena logo with the word Azthena
    https://www.news-medical.net/health/Causes-of-Food-Intolerance.aspx
    Food intolerance is a functional or structural intolerance to food, which is non-immunologic and non-toxic in origin, but is chemically based instead. […] A third type of food intolerance involves the effects produced by pharmacologically active amines and other compounds present in foods. […] Thus, food intolerance describes a range of food-related symptoms that are not immunologically-mediated. These account for the majority of food reactions. […] Functional food intolerance is not associated with structural abnormalities of the digestive tract, but may be due to an isolated enzyme deficiency. […] A prime example of functional food intolerance is lactose intolerance. […] Carbohydrate intolerances involve the inability to digest and absorb sorbitol, fructose or other simple sugars.
  • #104 Azthena logo with the word Azthena
    https://www.news-medical.net/health/Causes-of-Food-Intolerance.aspx
    Other than enzyme deficiencies, transporter molecule defects may be present. […] These include defects in GLUT 5, which transports fructose, or GLUT 2 for glucose, galactose or fructose. […] The inability to transport these carbohydrates into the intestinal cells results in their metabolism in the large intestine where they are transported intact in large quantities. […] Patients who are at risk for bacterial overgrowth include those who have been surgically treated by bowel resection, or are on chronic treatment with proton pump inhibitors, such as ranitidine or omeprazole. […] This leads to symptoms of food intolerance following ingestion of a number of foods, due to the release of excessive bacterial decomposition products in the gut. […] Many foods contain compounds with intrinsic biologic activity, such as salicylates, biogenic amines, and other substances that may lead to intolerance due to enzyme deficiencies.
  • #105 Sudden Food Intolerances in Adults (and Possible Causes) – JJ Virgin
    https://jjvirgin.com/sudden-food-intolerances-in-adults-and-possible-causes/
    Research shows the stress response can alter the natural balance of healthy bacteria in your gut, causing the gut ecology to shift in favor of a more hostile group of bacteria. […] Other studies show that stress and mood disorders such as depression compound each other and contribute to leaky gut and dysbiosis, creating an inflammatory response that starts in your gut, but like wildfire, spreads throughout your body. […] While new food intolerances may seem to come on suddenly, their development is a gradual process.
  • #106 Food Intolerances
    https://pmc.ncbi.nlm.nih.gov/articles/PMC6682924/
    Food intolerances are estimated to affect up to 20% of the population but complete understanding of diagnosis and management is complicated, given presentation and non-immunological mechanisms associated vary greatly. […] For many of the other food intolerances reviewed including non-coeliac gluten/wheat sensitivity, food additives and bioactive food chemicals, the findings show that there is a shortage of reproducible well-designed double-blind, placebo-controlled studies, making understanding of the mechanisms, diagnosis and management difficult. […] Enzyme deficiencies have been proposed to result in other food sensitivities including low amine oxidase activity resulting in histamine intolerance and sucrase-isomaltase deficiency resulting in reduced tolerance to sugars and starch. […] Lack of reliable diagnostic biomarkers for all food intolerances result in an inability to target specific foods in the individual.
  • #107 Food Intolerances
    https://pmc.ncbi.nlm.nih.gov/articles/PMC6682924/
    Given there are no validated diagnostic biomarkers, the definition according to the scientific literature for NCG/WS is where subjects are responsive to a gluten-free diet and react to re-challenge with gluten compared to placebo. […] There are no diagnostic tests available to assess food additive or chemical sensitivity.