Materiały źródłowe

• #1 Molluscum contagiosum – Diagnosis & treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/molluscum-contagiosum/diagnosis-treatment/drc-20375230

  Molluscum contagiosum usually gets better without treatment in 6 months to 2 years. Once the bumps are gone, you’re no longer contagious. After healing, it’s possible to become reinfected with the virus. […] For severe or widespread disease, your health care provider might refer you to a specialist in skin conditions (dermatologist) to discuss options for removing the bumps. […] Treatment might involve one or a combination of the following: A medicine that irritates the sores, such as retinoic acid or benzoyl peroxide, A medicine that causes blisters (cantharidin), which lifts off the bumps, Scraping, Freezing (cryotherapy), Laser therapy, which might be an option for people with a weakened immune system. […] Some procedures can be painful, so your health care provider may numb your skin first. Possible side effects of treatment are infection and scarring.

• #2 Molluscum Contagiosum: What it is, Symptoms & Treatment

  https://my.clevelandclinic.org/health/diseases/12175-molluscum-contagiosum

  Treatment for molluscum contagiosum isnt necessary, as the infection can clear up on its own. […] For children, people with a weakened immune system or people who have symptoms that cause pain and discomfort, treatment could include: […] Removing the papules: Your provider could use different therapies to remove visible signs of the condition from your skin by freezing the papule (cryotherapy), scraping out the papule (curettage) or using a laser to remove it (laser therapy). […] Taking medicine: Medicine is common to treat infections in kids like cimetidine (oral). […] Using topical creams or ointments: Topical creams and ointments speed up your recovery time and reduce symptoms. Topical medicine could include podophyllum, potassium hydroxide, salicylic acid, benzoyl peroxide and tretinoin. […] Removal of the papules could cause scarring. […] Treatment can reduce your symptoms, especially pain and itching, and can speed up your healing time.

• #3 Molluscum Contagiosum – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK441898/

  People frequently seek treatment for cosmetic reasons, to avoid social stigma, or because they have concerns of transmission to other individuals. […] The treatment depends on the patients (or their parent’s) preferences. Because the condition is usually self-limiting, awaiting spontaneous resolution should be considered. However, the patients should be aware that the resolution of molluscum contagiosum may take several months. Even though many treatments had been proposed for molluscum contagiosum, none has proven its effectiveness. Current treatment options include physical removal of mollusca, topical medications, and systemic treatment. […] Physical removal is based mainly on cryotherapy with liquid nitrogen or curettage. Techniques might be associated. Laser treatment (carbon dioxide or pulsed dye laser) may also be used but not as first-line therapy. Physical removal is usually painful and may require local anesthesia. Postoperative scarring is possible. Topical trichloroacetic acid can be used to treat mollusca with minimal scarring.

• #3 Molluscum Contagiosum – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK441898/

  Doctors recommend many topical treatments for molluscum contagiosum. Podophyllotoxin (contraindicated in pregnant women), potassium hydroxide, salicylic acid (associated or not with povidone-iodine), benzoyl peroxide, and tretinoin are used as home treatments and must be applied to each lesion. They are used with the aim to induce an inflammatory reaction, thus accelerating recovery. In a recent analysis, imiquimod, which is used as a modulator of the immune system, and cantharidin, a blistering topical applied by the physician, has not been found to be more effective than other vehicles. […] The use of oral cimetidine has been described as a safe alternative to physical removal in children who fear pain (except for facial involvement). However, a recent meta-analysis did not show any difference with cimetidine. Cidofovir, a DNA polymerase inhibitor, has been used successfully in immunosuppressed persons, but it may induce nephrotoxicity and neutropenia when used intravenously. In people living with HIV/AIDS, molluscum contagiosum is best managed with highly active antiretroviral therapy (HAART).

• #4 Molluscum Contagiosum Treatment & Management: Approach Considerations, Pharmacologic Therapy, Benign Neglect

  https://emedicine.medscape.com/article/910570-treatment

  In healthy patients, molluscum contagiosum is generally self-limited and heals spontaneously after several months. Individual lesions are seldom present for more than 2 months. Although treatment is not required, it may help to reduce autoinoculation or transmission to close contacts and improve clinical appearance. […] Intervention may also be indicated if lesions persist. Therapeutic modalities include topical application of various medications, radiation therapy, and/or surgery. Each technique may result in scarring or postinflammatory pigmentary changes. Frequently, multiple treatment sessions are necessary because of the recurrence of treated lesions and/or the appearance of new lesions. […] Therapeutic options for molluscum contagiosum can be divided into broad categories, including the following: Benign neglect, Direct lesional trauma, Antiviral therapy, Immune response stimulation.

• #4 Molluscum Contagiosum Treatment & Management: Approach Considerations, Pharmacologic Therapy, Benign Neglect

  https://emedicine.medscape.com/article/910570-treatment

  In a study of the treatment of molluscum contagiosum in children, Hanna et al determined that curettage was the most efficacious therapy. […] Curettage was found to be the most efficacious treatment and had the lowest rate of adverse effects. […] Repeat examination is recommended 2-4 weeks after treatment. Retreatment often is necessary. Consider combination therapy in patients whose lesions respond poorly. […] Clinical success has been reported with the use of the following topical agents, which may act as irritants, stimulating an immunologic response: Cantharidin topical, Berdazimer topical, Tretinoin, Bichloracetic acid, Trichloroacetic acid, Salicylic acid, Lactic acid, Glycolic acid, Silver nitrate, Potassium hydroxide, Dilute povidone iodine. […] Cantharidin is a chemovesicant that is highly effective in treating molluscum contagiosum; however, this agent has lost favor with some physicians because of concerns regarding its safety.

• #4 Molluscum Contagiosum Treatment & Management: Approach Considerations, Pharmacologic Therapy, Benign Neglect

  https://emedicine.medscape.com/article/910570-treatment

  The most appropriate therapeutic approach largely depends on the clinical situation. In healthy children, a major goal is to limit discomfort, and benign neglect or minor, direct lesional trauma is appropriate. In adults who are more motivated to have their lesions treated, cryotherapy or curettage of individual lesions is effective and well tolerated. […] In immunocompromised individuals, molluscum contagiosum may be very extensive and difficult to treat. The goal may be to treat the most troublesome lesions only. In severe cases, these patients may warrant more aggressive therapy with lasers, antiviral therapy, or a combination of these. […] In 2023, the US Food and Drug Administration (FDA) approved the first topical agent, cantharidin, for treatment of molluscum contagiosum. Another topical agent, berdazimer, was approved in early 2024.

• #5 Molluscum contagiosum: Diagnosis and treatment

  https://www.aad.org/public/diseases/a-z/molluscum-contagiosum-treatment

  If you have molluscum, your dermatologist may recommend letting this condition clear on its own rather than treating it. […] Treatment may be recommended for patients who have: […] If you have an HIV infection and molluscum, the bumps can be big and cover a large area of skin. Starting antiretroviral therapy (ART) can help clear your skin of molluscum. […] To avoid products that dont work and to prevent possible side effects, use a non-prescription product only when recommended by your dermatologist. […] If treatment is recommended, your dermatologist may recommend treatment that you: […] The goal of an in-office treatment is to destroy the bumps without harming the skin. […] When your dermatologist uses cantharidin (beetle juice) to treat molluscum, you need to wash it off at home with soap and water, within the time frame that your dermatologist gives you.

• #5 Molluscum contagiosum: Diagnosis and treatment

  https://www.aad.org/public/diseases/a-z/molluscum-contagiosum-treatment

  When applied by a dermatologist, cantharidin is a safe and effective treatment for molluscum. […] Cryosurgery can be painful, so its not always recommended for young children. […] During this treatment, your dermatologist uses a medical device called a curette to remove the molluscum bumps from the skin. […] This may be a treatment option for someone who has many molluscum bumps. […] Sometimes, molluscum is best treated with a medication that you apply at home. […] This prescription medication works to clear or reduce the bumps. […] This prescription medication helps stimulate the bodys immune system so that it will clear the bumps. […] While this is a non-prescription treatment, you should only use it if your dermatologist recommends it. […] For most people, the skin will clear without treatment, usually within 18 months. […] Treating molluscum may clear the skin more quickly; however, the bumps can return after treatment.

• #6 Molluscum Contagiosum: Epidemiology, Considerations, Treatment Options, and Therapeutic Gaps

  https://pmc.ncbi.nlm.nih.gov/articles/PMC10453394/

  Molluscum contagiosum (MC) is a viral infection that affects primarily pediatric patients, sexually active young adults, and immunocompromised people of all ages. […] Many treatments exist, but only onea drug-device product using topical cantharidin is approved by the United States (US) Food and Drug Administration (FDA) for treatment of MC. […] Unfortunately, this noninterventional approach can increase risk of spreading infection and result in longer duration of infection, physical discomfort, and psychosocial issues due to persistence of the MC lesions. […] The recently updated Red Book Atlas of Pediatric Infectious Diseases states that therapy for MC may be warranted to alleviate discomfort, including itching; reduce autoinoculation; limit transmission of the virus to close contacts and reduce cosmetic concerns and prevent secondary infections.

• #7 Update on the Treatment of Molluscum Contagiosum in Children | Actas Dermo-Sifiliográficas

  https://www.actasdermo.org/es-update-on-treatment-molluscum-contagiosum-articulo-S1578219018301379

  Because MC is benign and self-limiting, a wait-and-see approach is reasonable. […] The choice of treatment depends on the number of lesions, their location, potential adverse effects, parental preferences, and the physician’s experience. […] In principle, MC should be treated using modalities that cause minimal pain and scarring.

• #7 Update on the Treatment of Molluscum Contagiosum in Children | Actas Dermo-Sifiliográficas

  https://www.actasdermo.org/es-update-on-treatment-molluscum-contagiosum-articulo-S1578219018301379

  Molluscum contagiosum is one of the most common viral infections in childhood. It is a benign and usually self-limiting infection, but its treatment in children can be challenging, particularly when the patient presents multiple lesions or when lesions are symptomatic or highly visible. Several treatment options exist. Choice of treatment depends on the number and location of lesions, the prior experience of the treating physician, and the preferences of the child’s parents or carers. This article provides an update on treatment options for molluscum contagiosum, with a particular focus on immunocompetent pediatric patients. […] Treatment options for MC lesions are listed in Table 1. Those that have been used in pediatric patients are described below. […] Destructive methods are the most commonly used methods in routine practice and result in the destruction of keratinocytes infected by the MC virus. These simple and inexpensive procedures, when carried out by a suitably qualified health care professional, are very effective.

• #7 Update on the Treatment of Molluscum Contagiosum in Children | Actas Dermo-Sifiliográficas

  https://www.actasdermo.org/es-update-on-treatment-molluscum-contagiosum-articulo-S1578219018301379

  Curettage is a simple and relatively inexpensive procedure, with the added advantage that the tissue removed can be kept for histopathological analysis in case of diagnostic doubt. […] Curettage is probably one of the most effective methods. […] The umbilicated nucleus of the lesion can be manually removed using the hands or any one of a variety of instruments, including a scalpel, lancet, insulin needle, slide, or forceps. […] Trichloroacetic acid causes tissue destruction by immediate chemical coagulation and superficial necrosis. […] Salicylic acid is a keratolytic agent sold at concentrations of 10% to 30%. […] Hydrogen peroxide (HP) is a powerful oxidizing agent and antiseptic that can inactivate poxvirus in vitro. […] Cantharidin is a vesicant agent produced by the beetle Lytta vesicatoria.

• #7 Update on the Treatment of Molluscum Contagiosum in Children | Actas Dermo-Sifiliográficas

  https://www.actasdermo.org/es-update-on-treatment-molluscum-contagiosum-articulo-S1578219018301379

  Potassium hydroxide (KOH) is an alkali that penetrates and destroys the skin by dissolving keratin. […] The application of liquid nitrogen at 196C induces the formation of intracellular and extracellular ice crystals, which cause tissue destruction and changes in the cell membrane and circulation in the skin. […] Immunotherapeutic methods are based on the stimulation of a cellular and/or humoral immune response that can eliminate the viral infection. […] Oral cimetidine is an antagonist of H2 histamine receptors. […] Candidin, a substance derived from the purified extract of Candida albicans, is usually used to treat warts but has been proposed as a treatment option for MC. […] Silver nitrate is prepared with 0.2mL of a 40% aqueous solution of silver nitrate and 0.05g of flour. […] The evidence base supporting several treatments of scarce efficacy is weak, but they are harmless and generally well accepted by parents and caregivers.

• #8 FDA approves first treatment for molluscum contagiosum | FDA

  https://www.fda.gov/drugs/news-events-human-drugs/fda-approves-first-treatment-molluscum-contagiosum

  FDA has approved Ycanth (cantharidin) for the topical (used on the skin) treatment of molluscum contagiosum in adult and pediatric patients 2 years of age and older. Ycanth is the first FDA-approved treatment for molluscum. Ycanth is administered to patients only by health care providers. Providers apply a single application of Ycanth on the areas of patients skin with molluscum bumps every 3 weeks as needed. […] The efficacy of Ycanth for the treatment of molluscum in patients 2 years and older was established in two double-blind, randomized, placebo-controlled trials (Trial 1 [NCT03377790] and Trial 2 [NCT03377803]). […] Fifty-four percent of subjects treated with Ycanth achieved complete clearance of all treated molluscum bumps by day 84 compared to 13% of subjects treated with placebo.

• #9 Clinical Overview of Molluscum Contagiosum | Molluscum Contagiosum | CDC

  https://www.cdc.gov/molluscum-contagiosum/hcp/clinical-overview/index.html

  The lesions caused by molluscum are usually benign and resolve without scarring if left alone. Trying to remove lesions by scraping and scooping increases the risk of scarring and is not recommended for otherwise healthy people. […] Physical removal such as cryotherapy, curettage and laser therapy require a trained healthcare provider and often local anesthesia. These procedures can result in post-procedural pain, irritation, and scarring. […] Gradual removal of lesions may be achieved by oral therapy with cimetidine. This option is often preferred for pediatric patients because: It is less painful. Parents can administer it at home. It has less chance of leaving scars. […] While cimetidine is safe, painless, and well tolerated, facial mollusca do not respond as well as lesions elsewhere on the body. In patients with facial mollusca, consider other treatment options, such as topical therapy.

• #9 Clinical Overview of Molluscum Contagiosum | Molluscum Contagiosum | CDC

  https://www.cdc.gov/molluscum-contagiosum/hcp/clinical-overview/index.html

  There are a number of topical treatments that are available for molluscum infections. These treatments must be prescribed by a healthcare professional. […] Podophyllotoxin cream (0.5%) is a reliable home therapy for women who are not pregnant. Each lesion must be treated individually as the therapeutic effect is localized. It is not recommended during pregnancy due to the potential risk to the fetus. […] Other options for topical therapy include iodine and salicylic acid, potassium hydroxide and tretinoin. Another therapy, the blistering agent cantharidin, is available but must be applied in a healthcare provider’s office. […] Imiquimod (a T-cell modifier) is available for adults. It has not been proven effective in children and is not recommended for children due to possible adverse events.

• #9 Clinical Overview of Molluscum Contagiosum | Molluscum Contagiosum | CDC

  https://www.cdc.gov/molluscum-contagiosum/hcp/clinical-overview/index.html

  Thus far, the most effective therapy for immunocompromised people who have molluscum are those that boost their immune systems. […] In extreme cases, intralesional interferon has been used to treat facial lesions in these patients. However, interferon can cause severe and unpleasant side effects (flu-like symptoms, site tenderness, depression, and lethargy). These side effects make interferon a less desirable treatment. […] Radiation therapy is also of little benefit.

• #10 Molluscum contagiosum: Causes and treatment — DermNet

  https://dermnetnz.org/topics/molluscum-contagiosum

  There is no single perfect treatment of molluscum contagiosum since we are currently unable to kill the virus. In many cases no specific treatment is necessary. […] Physical treatments include picking out the soft white core (note, this could lead to autoinoculation), cryotherapy (can leave white marks), gentle curettage or electrodessication (can scar), and laser ablation (can scar). […] Medical treatments include antiseptics such as hydrogen peroxide cream or povidone iodine solution, podophyllotoxin cream, wart paints containing salicylic acid, cantharidine solution, and under review: berdazimer gel is under FDA review with anticipated approval in early 2024. […] Secondary dermatitis may be treated symptomatically with a mild topical topical corticosteroid such as hydrocortisone cream. Dermatitis is unlikely to fully resolve until the molluscum infection has cleared up.

• #11 Molluscum Contagiosum Treatment | Connecticut Dermatologist

  https://dermatologyofct.com/what-we-do/medical-surgical-dermatology/molluscum/

  As molluscum contagiosum is caused by a virus, the condition will persist until the immune system clears the virus. […] Your dermatologist will provide a customized treatment plan to help clear your childs molluscum infection as quickly as possible. […] There are many treatment options available for molluscum. Topical creams (imiquimod, tretinoin) might be used alone or in conjunction with other procedures aimed at eliminating the lesions. […] Procedures performed in dermatologist offices to remove molluscum lesions include cryotherapy (light freezing), curettage (scraping), and cantharidin (beetlejuice!) application. […] Your dermatologist will formulate a treatment plan that will minimize discomfort and speed resolution of this bothersome condition.

• #12 Molluscum contagiosum – Wikipedia

  https://en.wikipedia.org/wiki/Molluscum_contagiosum

  Prevention includes hand washing and not sharing personal items. […] While treatment is not necessary, some may wish to have the lesions removed for cosmetic reasons or to prevent spread. Removal may occur with freezing, laser therapy, or opening up the lesion and scraping the inside. […] The oral medication cimetidine, or podophyllotoxin cream applied to the skin, may also be used for treatment. […] Studies have found cantharidin to be an effective and safe treatment for removing molluscum contagiosum. […] Surgical treatments include cryosurgery, in which liquid nitrogen is used to freeze and destroy lesions, as well as scraping them off with a curette. […] A 2014 systematic review of case reports and case series concluded that the limited available data suggest pulsed dye laser therapy is a safe and effective treatment for molluscum contagiosum and is generally well tolerated by children. […] Berdazimer sodium is a medication used for the treatment for molluscum contagiosum. […] Imiquimod is a form of immunotherapy initially proposed as a treatment for molluscum based on promising results in small case series and clinical trials.

• #13

  https://link.springer.com/article/10.1007/s13555-022-00826-7

  Robust phase III trials are available for both drugs, showing complete clearance in 50% of patients treated with VP-102 and 32% of patients treated with SB206, with mild to moderate local skin reactions. […] Based on good results in terms of safety and efficacy, VP-102 and SB2016 have the potential to be the first FDA-approved MC therapies. […] Treatment of MC is especially indicated in patients with extensive disease, for esthetic reasons, or in case of secondary complications (bacterial superinfection, molluscum dermatitis, or conjunctivitis). […] A wide variety of treatments with different levels of evidence are available for the management of MC. […] The choice to adopt one approach or another depends on different factors, including the number/localization of lesions, the clinicians experience, and the patients characteristics and compliance.

• #13

  https://link.springer.com/article/10.1007/s13555-022-00826-7

  A large variety of treatments for molluscum contagiosum (MC) are available, but none are Food and Drug Administration (FDA) approved and there is no consensus on the optimal approach, mainly owing to a lack of high-level data. […] Two experimental topical drugs, a new standardized preparation of topical cantharidin, called VP-102, and a topical nitric oxide (NO)-releasing product containing berdazimer, called SB206, represent promising products that have been designed to overcome the limitations of current treatments. […] VP-102 is a proprietary drug-delivery device combination containing cantharidin 0.7% [w/v] in a film-forming topical solution designed to overcome compounded cantharidin formulation limitations and application concerns. […] SB206 is a new nitric oxide (NO)-releasing topical drug consisting of a gel containing berdazimer sodium and a carboxymethyl cellulose hydrogel that acts as a proton donor.

• #14

  https://111.wales.nhs.uk/molluscumcontagiosum/?locale=en

  Treatment is also be recommended for people with weakened immune systems, as the condition can take several years to clear in these cases. […] There are a number of topical treatments (creams, lotions and ointments) that can be used to treat MC, although there’s not enough evidence to know if any particular treatment is more effective than the others. […] Potassium hydroxide is a medicine available in liquid form that can improve MC by breaking down the skin cells infected by the virus. […] Podophyllotoxin comes in liquid form and poisons the cells of the spots. […] Imiquimod is a cream that can be used to treat larger spots or large clusters of spots. […] Benzoyl peroxide is usually available in cream or gel form. […] Tretinoin is available as a liquid that’s applied once or twice a day to individual spots.

• #15 Safely Treating Molluscum, a Common Skin Condition | FDA

  https://www.fda.gov/consumers/consumer-updates/safely-treating-molluscum-common-skin-condition

  Do not purchase or use nonprescription (over-the-counter, or OTC) products that claim to treat molluscum, even if the companies make statements that suggest their product may have been reviewed or is endorsed by the FDA. […] Its likely that unapproved products marketed to treat molluscum do not do what they claim, and the ingredients in them could cause adverse effects (bad reactions). The FDA has received reports of side effects in children and adults associated with some of these products, including skin reddening, abrasion from skin scratching, and permanent scarring. […] Many unapproved products claiming to treat molluscum contain essential oils. Even natural substances, such as essential oils, may cause an allergic reaction or irritate sensitive skin.

• #16 Molluscum Contagiosum – Dermatologic Disorders – Merck Manual Professional Edition

  https://www.merckmanuals.com/professional/dermatologic-disorders/viral-skin-diseases/molluscum-contagiosum

  Cantharidin is safe and effective but can cause blistering. […] Curettage or cryotherapy (using liquid nitrogen) can be performed 40 to 60 minutes after application of a topical anesthetic such as EMLA (lidocaine/prilocaine) cream or 4% lidocaine cream under an occlusive dressing. […] Other treatments include intralesional injection (eg, with Candida antigen or rarely interferon alpha in immunocompromised patients) and photodynamic therapy. […] Oral cimetidine is a histamine-receptor antagonist with immunomodulatory properties, has been effective in clearing topical lesions in some pediatric patients. […] Before selecting a treatment option, it is helpful to evaluate the strength of evidence backing these therapies, their local availabilities and costs.

• #16 Molluscum Contagiosum – Dermatologic Disorders – Merck Manual Professional Edition

  https://www.merckmanuals.com/professional/dermatologic-disorders/viral-skin-diseases/molluscum-contagiosum

  Treatment of molluscum contagiosum is aimed at preventing spread or removing cosmetically unacceptable lesions and can include mechanical methods (eg, curettage, cryosurgery) and topical agents (eg, cantharidin, tretinoin, berdazimer). […] Treatment of molluscum contagiosum is indicated for cosmetic reasons and for prevention of spread. Options include curettage, cryosurgery, laser therapy, electrocautery, trichloroacetic acid (25 to 40% solution), cantharidin, podophyllotoxin (podofilox) in adults, berdazimer, tretinoin, and tazarotene. […] Treatments that cause minimal pain (eg, tretinoin, tazarotene, cantharidin) used first, especially in children. […] Berdazimer 10.3% gel is a topical agent available for use in patients 1 year and older that has demonstrated favorable efficacy (ie, clearing all molluscum lesions in over one-third of patients) and safety in randomized trials.

• #17 Molluscum Contagiosum: Causes, Symptoms, and More

  https://www.healthline.com/health/molluscum-contagiosum

  creams that contain iodine and salicylic acid or potassium hydroxide […] trichloroacetic acid […] topical podophyllotoxin cream (Condylox) […] cantharidin (Cantharone), a blistering agent that a doctor usually applies […] imiquimod (Aldara), a T cell modifier […] Antiretroviral therapy (ART) is the most effective treatment for people who live with HIV if they contract molluscum contagiosum. It can help strengthen the immune system and fight the virus. […] Seek consultation with your doctor before attempting any treatments for molluscum contagiosum.

• #18 Comprehensive Management of Molluscum Contagiosum: Assessment of Clinical Associations, Comorbidities, and Management Principles | JCAD – The Journal of Clinical and Aesthetic Dermatology

  https://jcadonline.com/comprehensive-management-of-molluscum-contagiosum/

  Recently, however, the FDA approved a pharmaceutical-grade, ether-free, topical cantharidin 0.7% solution prepared as a combined drug-device product (YCANTH, Verrica Pharmaceuticals, West Chester, Pennsylvania), which now provides clinicians with an evidence-based, standardized formulation of topical cantharidin that can be delivered with specified dosing recommendations and application technique to individual MC lesions. […] The availability of the first FDA-approved MC treatment is a drug-device product that allows a healthcare professional to apply pharmaceutical-grade topical cantharidin 0.7% solution to MC lesions in a directed fashion, the use of which is supported by randomized, controlled, pivotal trials establishing both efficacy and safety.

• #18 Comprehensive Management of Molluscum Contagiosum: Assessment of Clinical Associations, Comorbidities, and Management Principles | JCAD – The Journal of Clinical and Aesthetic Dermatology

  https://jcadonline.com/comprehensive-management-of-molluscum-contagiosum/

  While the benign neglect approach to treating MC might appeal to patients with MC, especially the parents/caretakers of children with MC, what is often lost in its explanation is that MC can potentially persist for several months to years in many individuals, can be spread to others who are in close personal contact with the patient, and can lead to real world psychosocial issues in the patient (e.g., feelings of embarrassment and/or fear of transmitting the virus to others, anxiety, social isolation). […] Additionally, the pain and pruritus associated with MC can also negatively impact a pediatric patients quality of life, which further underscores the importance of taking an active approach to treatment of MC and should be factored in the clinician-patient/parent decision-making process.

• #18 Comprehensive Management of Molluscum Contagiosum: Assessment of Clinical Associations, Comorbidities, and Management Principles | JCAD – The Journal of Clinical and Aesthetic Dermatology

  https://jcadonline.com/comprehensive-management-of-molluscum-contagiosum/

  When treating patients with MC, the initial assessment should involve a thorough clinical examination to determine the extent, location(s), and number of lesions. […] Clinicians are encouraged to be thorough when discussing treatment options of MC with their patients or patient caregivers, including educating them on the lack of cure, the potential need for repeated courses of therapy, and the potential adverse effects of individual treatment options. […] There are numerous treatment options for MC, which are thoroughly reviewed elsewhere as well as in more detail in the article, Molluscum Contagiosum: Epidemiology, Treatment Options, and Therapeutic Gaps. […] Topical application of cantharidin is a commonly used clinician-directed treatment that is supported by a thorough literature review on its use in MC and verrucae.

• #18 Comprehensive Management of Molluscum Contagiosum: Assessment of Clinical Associations, Comorbidities, and Management Principles | JCAD – The Journal of Clinical and Aesthetic Dermatology

  https://jcadonline.com/comprehensive-management-of-molluscum-contagiosum/

  Despite its high global prevalence, molluscum contagiosum (MC) is not well understood outside of dermatology. […] A primary goal of this review is to increase awareness among dermatologists and other healthcare professionals of the importance of actively treating MC in all presenting patients, especially those with compromised immune systems, versus letting the virus run its course with no active intervention. […] There are multiple treatment approaches to managing MC that have been described in the literature. […] A cross-sectional survey of 2,000 healthcare professionals that included primary care physicians, pediatricians, obstetrician-gynecologists, dermatologists, nurse practitioners, and registered dietitians evaluated clinician knowledge, attitudes, and practice related to treatment of MC.

• #19 Molluscum Contagiosum | Lurie Children’s

  https://www.luriechildrens.org/en/specialties-conditions/molluscum-contagiosum/

  Although molluscum eventually resolve, lesions spread easily, may become infected, may be itchy or irritated and are sometimes cosmetically objectionable. Therefore, they are often removed. The treatment depends on the age of the patient and the size and location of the growths. […] Cantharone, a blistering agent made from beetles, is applied with a wooden applicator to the skin growth. The medicine should be washed off in 4 to 6 hours. A small blister usually forms in a few hours to one day. When the scab falls off, the growth is gone. This treatment is useful because the application is not painful; it is used carefully and selectively on the face and in skin creases. Occasionally no blistering occurs, but sometimes, children are quite sensitive and extensive blistering is seen. Scarring does not occur from Cantharone treatment. Although the blisters are uncomfortable, they are very superficial and resolve within a few days. Compresses with lukewarm water and breaking the blisters with a sterile needle may help.

• #20 Molluscum contagiosum: Tips for managing

  https://www.aad.org/public/diseases/a-z/molluscum-contagiosum-tips

  If the bumps itch, ask your dermatologist if you can apply hydrocortisone cream or ointment to reduce the itch. […] Treat the bumps only if your dermatologist or other health care provider recommends doing so. […] If molluscum bumps appear in the genital area, stop sexual activity and see a board-certified dermatologist or your healthcare provider. Treatment is usually recommended for anyone who has molluscum bumps in the genital area (on or near the penis, vulva, vagina, or anus). Your healthcare provider can tell you when you can have sexual activity again.

• #21 Molluscum contagiosum — treatment and symptoms | healthdirect

  https://www.healthdirect.gov.au/molluscum-contagiosum

  Molluscum contagiosum usually heals in about 6 to 9 months without any treatment. Some people, for example if you have problems with your immune system, can have spots for years. […] Treatment may involve: freezing the spots off with liquid nitrogen, squeezing them gently and pricking with a needle, surgically scraping them off, using a cream or lotion, using wart paint. […] The spots usually heal without leaving a scar, but some treatments and scratching can leave marks. […] If the person has a skin condition such as eczema, its best to treat the condition before treating molluscum contagiosum.

• #22 Molluscum Contagiosum (for Parents) | Nemours KidsHealth

  https://kidshealth.org/en/parents/molluscum-contagiosum.html

  Most of the time, molluscum clears up on its own without treatment. Each bump goes away in about 2-3 months. New bumps can appear as old ones go away, so it can take 6-12 months (and sometimes longer) for molluscum to fully go away. […] Sometimes, doctors remove the bumps or help them go away more quickly. To do this, they can: Freeze the bumps off. Scrape or cut the bumps off. Put a chemical on the bumps to make the body fight them away faster. Put medicine on the bumps or give medicine to swallow. […] Many doctors don’t recommend these treatments for kids, though. That’s because they can be painful and burn, blister, stain, or scar the skin. When deciding to treat a rash, they consider where the bumps are and if they’re causing itching, pain, or other problems. […] Talk with your child’s doctor about the pros and cons of treating molluscum. The rash usually doesn’t cause long-term problems or leave scars. Often, the best way to handle it is to be patient, as hard as that might be.

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