Materiały źródłowe

• #1 Cytomegalovirus (CMV) infection – Symptoms & causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/cmv/symptoms-causes/syc-20355358

  Cytomegalovirus (CMV) is a common virus. Once infected, your body retains the virus for life. Most people don’t know they have cytomegalovirus (CMV) because it rarely causes problems in healthy people. […] If you’re pregnant or if your immune system is weakened, CMV is cause for concern. Women who develop an active CMV infection during pregnancy can pass the virus to their babies, who might then experience symptoms. For people who have weakened immune systems, especially people who have had an organ, stem cell or bone marrow transplant, CMV infection can be fatal. […] Most healthy people who are infected with CMV may experience no symptoms. Some experience minor symptoms. People who are more likely to experience signs and symptoms of CMV include: Newborns who became infected with CMV before they were born (congenital CMV). Infants who become infected during birth or shortly afterward (perinatal CMV). This group includes babies infected through breast milk.

• #2 Cytomegalovirus (CMV) Infection – Infections – Merck Manual Consumer Version

  https://www.merckmanuals.com/home/infections/herpesvirus-infections/cytomegalovirus-cmv-infection

  Cytomegalovirus infection is a common herpesvirus infection with a wide range of symptoms: from no symptoms to fever and fatigue (resembling infectious mononucleosis) to severe symptoms involving the eyes, brain, or other internal organs. […] Most people have no symptoms, but some feel ill and have a fever, and people with a weakened immune system can have serious symptoms, including blindness. […] Usually, CMV infection causes no symptoms. Serious infections typically develop only in infants infected before birth and in people with a weakened immune systemfor example, people with AIDS or those who have received an organ transplant. […] A few infected people feel ill and have a fever. […] In people with a weakened immune system, CMV can cause serious disease or death. […] In people with AIDS, CMV infection is a common viral complication. The virus can infect the retina of the eye. This infection (CMV retinitis) can cause blindness.

• #3 Cytomegalovirus (CMV)

  https://www.health.ny.gov/diseases/communicable/cytomegalovirus/fact_sheet.htm

  CMV is a common virus that infects 50 to 80 percent of people at some time during their lives but rarely causes obvious illness. […] Most children and adults who are infected with CMV do not develop symptoms. Those who develop symptoms may experience an illness resembling infectious mononucleosis and have fever, swollen glands and feel tired. […] Approximately 8 out of every 1,000 babies born in the United States will have CMV infection, of which 1 to 2 may have significant illness involving nervous system damage or developmental disabilities. […] Although most people never develop symptoms after exposure, the incubation period appears to be between 3 and 12 weeks. […] No treatment is currently indicated for CMV infection in healthy individuals. Antiviral treatment is used for immunocompromised individuals who have eye infections or life-threatening illnesses due to CMV.

• #4 Cytomegalovirus (cmv) | Health and wellbeing | Queensland Government

  https://www.qld.gov.au/health/condition/infections-and-parasites/viral-infections/cytomegalovirus-cmv

  By adulthood, 40% or more of the adult population have been infected. Most of these infections will have been acquired in childhood and many of the children would have had no symptoms. Because most infections with CMV are not apparent, people may be infected or acquire the infection and not realise it. As the infection is never eliminated from the body, the symptoms from the virus can show years later if the person’s immune system is weakened, such as those with some cancers, those undergoing cancer treatment, or people with AIDS. […] The most severe form of the illness occurs in infants infected in utero, however most babies born with CMV infection grow up with normal health.

• #5 Cytomegalovirus (CMV) infection – including symptoms treatment and prevention | SA Health

  https://www.sahealth.sa.gov.au/wps/wcm/connect/public+content/sa+health+internet/conditions/infectious+diseases/cytomegalovirus+cmv+infection/cytomegalovirus+cmv+infection+-+including+symptoms+treatment+and+prevention

  This infection is caused by cytomegalovirus (CMV). This virus occurs worldwide and humans are the only source of human CMV. […] CMV infection can spread in different ways. The virus can be passed from person-to-person, usually through close contact with saliva, breast milk, urine or other body fluid, or through sexual contact with someone with the infection. […] Infection in children and adults is usually without symptoms. […] Occasionally, symptoms similar to glandular fever such as fever, sore throat, swollen glands, abdomen pain and jaundice (yellow skin and eyes) can occur. […] CMV infection can result in severe disease for: babies, people who receive solid organ transplants or bone marrow/stem cell transplants, people with severe immune suppression such as advanced human immunodeficiency virus (HIV) infection.

• #6 Cytomegalovirus (CMV): Symptoms, Causes, Treatment

  https://www.webmd.com/hiv-aids/aids-hiv-opportunistic-infections-cytomegalovirus

  Cytomegalovirus infection is common, and most people have had it without knowing. But if you get infected during pregnancy, it may cause health problems for your developing baby. […] CMV spreads easily through an infected person’s saliva or other body fluids. […] In people who have advanced HIV, CMV can cause an eye infection called retinitis, which may lead to blindness. […] Most healthy people who get CMV don’t know it. You could have minor symptoms. Those who are most likely to have symptoms include: Newborns who get CMV before birth, Infants infected during or soon after birth, Recipients of organ, bone marrow, or stem cell transplants, Those infected with HIV. […] If you have symptoms of primary CMV, they’re mild and include: Fatigue, Swollen glands, Fever, Chills, Sore throat, Muscle aches, Headache, Antibiotic rash, Changes in liver function, Mononucleosis syndrome.

• #7 Cytomegalovirus and pregnancy | March of Dimes

  https://www.marchofdimes.org/find-support/topics/planning-baby/cytomegalovirus-and-pregnancy

  Cytomegalovirus (also called CMV) is the most common infection passed from pregnant people to babies during pregnancy. […] If you get infected with CMV during pregnancy, it may cause pregnancy loss or serious health problems in your baby, including preterm birth or low birthweight, or hearing loss at birth or later in life. […] Most people with CMV infection have no symptoms and aren’t aware that they have been infected. […] Signs and symptoms of CMV can be different in healthy people, babies and people with weak immune systems. […] Signs and symptoms of CMV in healthy people may include: Chills and/or sweats, Decreased appetite, Fatigue (being very tired and having little energy), Fever, Headache, Muscle aches, Sore throat, Swollen glands. […] People with weakened immune systems who get CMV can have more serious problems that can affect the eyes, lungs, liver, esophagus, stomach and intestines.

• #8 About Cytomegalovirus | Cytomegalovirus (CMV) and Congenital CMV Infection | CDC

  https://www.cdc.gov/cytomegalovirus/about/index.html

  Most people with CMV show no signs or symptoms and arent aware that they have been infected. […] Sometimes, infection in healthy people can cause mild illness like: Fever, Sore throat, Fatigue, Swollen glands. […] Occasionally, CMV can cause mononucleosis or hepatitis (liver problems). […] If you have a weakened immune system and get CMV, you can have more serious symptoms affecting the eyes; lungs; liver; esophagus; stomach; and intestines. […] Babies born with CMV can have brain, liver, spleen, lung, and growth problems. The most common long-term health problem in babies born with CMV infection is hearing loss. This may be detected soon after birth or may develop later in childhood. […] About 1 in 200 babies is born with congenital CMV infection. About 1 in 5 babies with congenital CMV infection will have birth defects or other long-term health problems.

• #9 Cytomegalovirus (CMV) | Better Health Channel

  https://www.betterhealth.vic.gov.au/health/conditionsandtreatments/cytomegalovirus-cmv

  Cytomegalovirus (CMV) is a member of the herpes family. In healthy people, it causes a mild flu-like illness that lasts a few days or weeks. In susceptible people, such as those with suppressed immunity or unborn babies, CMV can be a dangerous infection. […] In healthy people, CMV infection causes nothing more than a flu-like illness that lasts a few days. In certain people, however, including transplant patients and pregnant women, the effects can be much more serious. […] Symptoms may vary depending on which organ is affected, but generally a person with CMV will experience lethargy, a high temperature and a drop in white blood cell levels. […] For most people, a CMV infection poses no real health threat. The symptoms are generally mild and flu-like, although some may feel unwell for a few weeks, rather than a few days. Some people experience no symptoms.

• #10 Cytomegalovirus (CMV) infection – Symptoms & causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/cmv/symptoms-causes/syc-20355358

  Cytomegalovirus (CMV) is a common virus. Once infected, your body retains the virus for life. Most people don’t know they have cytomegalovirus (CMV) because it rarely causes problems in healthy people. […] If you’re pregnant or if your immune system is weakened, CMV is cause for concern. Women who develop an active CMV infection during pregnancy can pass the virus to their babies, who might then experience symptoms. For people who have weakened immune systems, especially people who have had an organ, stem cell or bone marrow transplant, CMV infection can be fatal. […] Most healthy people who are infected with CMV may experience no symptoms. Some experience minor symptoms. People who are more likely to experience signs and symptoms of CMV include: Newborns who became infected with CMV before they were born (congenital CMV). Infants who become infected during birth or shortly afterward (perinatal CMV). This group includes babies infected through breast milk.

• #11 Cytomegalovirus (CMV) Infection: Causes & Symptoms

  https://my.clevelandclinic.org/health/diseases/21166-cytomegalovirus

  Cytomegalovirus (CMV) is a common infection from a herpes virus. If you get infected shortly before or during pregnancy, you can give birth to a baby with congenital CMV. Congenital CMV can cause hearing loss and developmental issues. CMV can cause serious complications in people who have a compromised immune system, such as transplant recipients. […] Symptoms of CMV vary depending on: […] Whether the person whos infected has a healthy or compromised immune system. […] Whether the infection is present at birth (congenital) or happens later. […] Most people who have a healthy immune system dont get symptoms of CMV. Those with noticeable symptoms often have CMV mononucleosis, which can cause: […] Extreme tiredness (fatigue). […] Muscle aches. […] Sweating. […] Headache. […] Sore throat.

• #12 Cytomegalovirus (CMV) Infection – Infections – Merck Manual Consumer Version

  https://www.merckmanuals.com/home/infections/herpesvirus-infections/cytomegalovirus-cmv-infection

  Cytomegalovirus infection is a common herpesvirus infection with a wide range of symptoms: from no symptoms to fever and fatigue (resembling infectious mononucleosis) to severe symptoms involving the eyes, brain, or other internal organs. […] Most people have no symptoms, but some feel ill and have a fever, and people with a weakened immune system can have serious symptoms, including blindness. […] Usually, CMV infection causes no symptoms. Serious infections typically develop only in infants infected before birth and in people with a weakened immune systemfor example, people with AIDS or those who have received an organ transplant. […] A few infected people feel ill and have a fever. […] In people with a weakened immune system, CMV can cause serious disease or death. […] In people with AIDS, CMV infection is a common viral complication. The virus can infect the retina of the eye. This infection (CMV retinitis) can cause blindness.

• #13 Cytomegalovirus (CMV) Infection: Causes & Symptoms

  https://my.clevelandclinic.org/health/diseases/21166-cytomegalovirus

  Cytomegalovirus (CMV) is a common infection from a herpes virus. If you get infected shortly before or during pregnancy, you can give birth to a baby with congenital CMV. Congenital CMV can cause hearing loss and developmental issues. CMV can cause serious complications in people who have a compromised immune system, such as transplant recipients. […] Symptoms of CMV vary depending on: […] Whether the person whos infected has a healthy or compromised immune system. […] Whether the infection is present at birth (congenital) or happens later. […] Most people who have a healthy immune system dont get symptoms of CMV. Those with noticeable symptoms often have CMV mononucleosis, which can cause: […] Extreme tiredness (fatigue). […] Muscle aches. […] Sweating. […] Headache. […] Sore throat.

• #14 Cytomegalovirus (CMV) Infection – Infections – Merck Manual Consumer Version

  https://www.merckmanuals.com/home/infections/herpesvirus-infections/cytomegalovirus-cmv-infection

  Cytomegalovirus infection is a common herpesvirus infection with a wide range of symptoms: from no symptoms to fever and fatigue (resembling infectious mononucleosis) to severe symptoms involving the eyes, brain, or other internal organs. […] Most people have no symptoms, but some feel ill and have a fever, and people with a weakened immune system can have serious symptoms, including blindness. […] Usually, CMV infection causes no symptoms. Serious infections typically develop only in infants infected before birth and in people with a weakened immune systemfor example, people with AIDS or those who have received an organ transplant. […] A few infected people feel ill and have a fever. […] In people with a weakened immune system, CMV can cause serious disease or death. […] In people with AIDS, CMV infection is a common viral complication. The virus can infect the retina of the eye. This infection (CMV retinitis) can cause blindness.

• #15 Cytomegalovirus (CMV) Infection: Causes & Symptoms

  https://my.clevelandclinic.org/health/diseases/21166-cytomegalovirus

  Cytomegalovirus (CMV) is a common infection from a herpes virus. If you get infected shortly before or during pregnancy, you can give birth to a baby with congenital CMV. Congenital CMV can cause hearing loss and developmental issues. CMV can cause serious complications in people who have a compromised immune system, such as transplant recipients. […] Symptoms of CMV vary depending on: […] Whether the person whos infected has a healthy or compromised immune system. […] Whether the infection is present at birth (congenital) or happens later. […] Most people who have a healthy immune system dont get symptoms of CMV. Those with noticeable symptoms often have CMV mononucleosis, which can cause: […] Extreme tiredness (fatigue). […] Muscle aches. […] Sweating. […] Headache. […] Sore throat.

• #16 Cytomegalovirus (CMV) Infection: Causes & Symptoms

  https://my.clevelandclinic.org/health/diseases/21166-cytomegalovirus

  Cytomegalovirus (CMV) is a common infection from a herpes virus. If you get infected shortly before or during pregnancy, you can give birth to a baby with congenital CMV. Congenital CMV can cause hearing loss and developmental issues. CMV can cause serious complications in people who have a compromised immune system, such as transplant recipients. […] Symptoms of CMV vary depending on: […] Whether the person whos infected has a healthy or compromised immune system. […] Whether the infection is present at birth (congenital) or happens later. […] Most people who have a healthy immune system dont get symptoms of CMV. Those with noticeable symptoms often have CMV mononucleosis, which can cause: […] Extreme tiredness (fatigue). […] Muscle aches. […] Sweating. […] Headache. […] Sore throat.

• #17 Cytomegalovirus (CMV) Infection: Causes & Symptoms

  https://my.clevelandclinic.org/health/diseases/21166-cytomegalovirus

  Swollen lymph nodes. […] Rash. […] If you have a weakened immune system (immunocompromised), you might get a new CMV infection or have a previous infection that reactivates when your body is no longer able to fight it off easily. Symptoms depend on what part of your body the virus infects and could include: […] Fever. […] Fatigue. […] CMV pneumonitis (shortness of breath, cough, muscle aches, weakness). […] CMV retinitis (blurry vision or loss of vision). […] CMV gastritis or colitis (stomach pain, blood in your poop, nausea, vomiting, diarrhea). […] CMV encephalitis (seizures, headaches, confusion). […] Congenital (present at birth) CMV is when the virus passes through the placenta to the fetus. Some babies wont have any symptoms at birth but go on to develop certain symptoms later on. Symptoms present at birth include:

• #18 Cytomegalovirus (CMV) infection: MedlinePlus Medical EncyclopediaLock

  https://medlineplus.gov/ency/article/000568.htm

  Cytomegalovirus (CMV) infection is a disease caused by a type of herpes virus. […] Most people come into contact with CMV in their lifetime, often early in life. But usually, people with a weakened immune system, such as those with HIV/AIDS, become ill from CMV infection. Some otherwise healthy people with CMV infection develop mononucleosis-like symptoms. […] Many people are exposed to CMV early in life, but do not realize it because they have no symptoms, or they have mild symptoms that resemble the common cold or flu. These may include: Enlarged lymph nodes, especially in the neck, Fever, Fatigue, Loss of appetite, Malaise, Muscle aches, Rash, Sore throat. […] CMV can cause infections in different parts of the body. Symptoms vary depending on the area that is affected. Examples of body areas that can be infected by CMV are: The lungs, The stomach or intestine, The back of the eye (retina), A baby while still in the womb (congenital CMV). […] The outcome is good with treatment. The symptoms may be relieved in a few weeks to months.

• #19 Cytomegalovirus (CMV) Infection: Causes & Symptoms

  https://my.clevelandclinic.org/health/diseases/21166-cytomegalovirus

  Swollen lymph nodes. […] Rash. […] If you have a weakened immune system (immunocompromised), you might get a new CMV infection or have a previous infection that reactivates when your body is no longer able to fight it off easily. Symptoms depend on what part of your body the virus infects and could include: […] Fever. […] Fatigue. […] CMV pneumonitis (shortness of breath, cough, muscle aches, weakness). […] CMV retinitis (blurry vision or loss of vision). […] CMV gastritis or colitis (stomach pain, blood in your poop, nausea, vomiting, diarrhea). […] CMV encephalitis (seizures, headaches, confusion). […] Congenital (present at birth) CMV is when the virus passes through the placenta to the fetus. Some babies wont have any symptoms at birth but go on to develop certain symptoms later on. Symptoms present at birth include:

• #20 Cytomegalovirus (CMV) Infection: Causes & Symptoms

  https://my.clevelandclinic.org/health/diseases/21166-cytomegalovirus

  Cytomegalovirus (CMV) is a common infection from a herpes virus. If you get infected shortly before or during pregnancy, you can give birth to a baby with congenital CMV. Congenital CMV can cause hearing loss and developmental issues. CMV can cause serious complications in people who have a compromised immune system, such as transplant recipients. […] Symptoms of CMV vary depending on: […] Whether the person whos infected has a healthy or compromised immune system. […] Whether the infection is present at birth (congenital) or happens later. […] Most people who have a healthy immune system dont get symptoms of CMV. Those with noticeable symptoms often have CMV mononucleosis, which can cause: […] Extreme tiredness (fatigue). […] Muscle aches. […] Sweating. […] Headache. […] Sore throat.

• #21 Cytomegalovirus (CMV) Infection: Causes & Symptoms

  https://my.clevelandclinic.org/health/diseases/21166-cytomegalovirus

  Cytomegalovirus (CMV) is a common infection from a herpes virus. If you get infected shortly before or during pregnancy, you can give birth to a baby with congenital CMV. Congenital CMV can cause hearing loss and developmental issues. CMV can cause serious complications in people who have a compromised immune system, such as transplant recipients. […] Symptoms of CMV vary depending on: […] Whether the person whos infected has a healthy or compromised immune system. […] Whether the infection is present at birth (congenital) or happens later. […] Most people who have a healthy immune system dont get symptoms of CMV. Those with noticeable symptoms often have CMV mononucleosis, which can cause: […] Extreme tiredness (fatigue). […] Muscle aches. […] Sweating. […] Headache. […] Sore throat.

• #22 Cytomegalovirus (CMV) infection: MedlinePlus Medical EncyclopediaLock

  https://medlineplus.gov/ency/article/000568.htm

  Cytomegalovirus (CMV) infection is a disease caused by a type of herpes virus. […] Most people come into contact with CMV in their lifetime, often early in life. But usually, people with a weakened immune system, such as those with HIV/AIDS, become ill from CMV infection. Some otherwise healthy people with CMV infection develop mononucleosis-like symptoms. […] Many people are exposed to CMV early in life, but do not realize it because they have no symptoms, or they have mild symptoms that resemble the common cold or flu. These may include: Enlarged lymph nodes, especially in the neck, Fever, Fatigue, Loss of appetite, Malaise, Muscle aches, Rash, Sore throat. […] CMV can cause infections in different parts of the body. Symptoms vary depending on the area that is affected. Examples of body areas that can be infected by CMV are: The lungs, The stomach or intestine, The back of the eye (retina), A baby while still in the womb (congenital CMV). […] The outcome is good with treatment. The symptoms may be relieved in a few weeks to months.

• #23 Cytomegalovirus – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK459185/

  Cytomegalovirus (CMV) is a wide-spread virus, with manifestations ranging from asymptomatic to severe end-organ dysfunction in immunocompromised patients with congenital CMV disease. […] CMV infection may be asymptomatic in healthy people, but it can be life-threatening in an immunocompromised patient. Congenital cytomegalovirus infection can cause morbidity and even death. After infection, CMV often remains latent, but it can reactivate at any time. Eventually, it causes mucoepidermoid carcinoma, and it may be responsible for prostate cancer. […] Primary CMV infection usually has an asymptomatic or subclinical course. Mononucleosis is the most prevalent presentation of CMV in patients with an intact immune system, characterized by fever, rash, and leukocytosis. […] In patients with a depressed immune system, CMV is more aggressive. Specific disease entities include: CMV hepatitis which may lead to fulminant liver failure, Cytomegalovirus retinitis characterized by a „pizza pie appearance” on ophthalmic exam, CMV esophagitis, Cytomegalovirus colitis, CMV pneumonitis, Polyradiculopathy, Transverse myelitis, Subacute encephalitis.

• #24 Cytomegalovirus (CMV) Infection: Symptoms, Treatment, Pregnancy

  https://www.medicinenet.com/cytomegalovirus_cmv/article.htm

  Cytomegalovirus (pronounced si-to-MEG-a-lo-virus), or CMV, is a virus that belongs to the Herpesviridae family, hence its older name, „human herpesvirus 5 (HHV 5)”. After primary infection, this group of viruses can infect many-body systems and remain dormant in those cells for life. This is called „latent” infection. Latent infection can „reactivate” later in life to cause disease again. Primary infection with CMV is common and may be asymptomatic. Primary CMV is one of the common causes of mononucleosis, or flu-like syndrome, including fever, fatigue, tiredness, malaise, and other symptoms. […] Most people infected with CMV do not report a history of symptoms or complications and do not recall any contact with an infected person, so most people are unaware they have been infected. Acute CMV infection may mimic flu or infectious mononucleosis caused by Epstein-Barr virus or liver infection by hepatitis A, B, or C. Mono-like symptoms may include fever, malaise (feeling unwell), enlarged lymph nodes, sore throat, muscle aches, loss of appetite, enlarged liver or spleen, and fatigue.

• #25 Cytomegalovirus (CMV) (for Parents) | Nemours KidsHealth

  https://kidshealth.org/en/parents/cytomegalovirus.html

  These babies are also at risk for hearing, vision, neurological, and developmental problems. Even babies without clear symptoms are at risk for congenital hearing loss. CMV is the most common cause of non-genetic hearing loss at birth. […] CMV infections that happen in kids after the newborn period usually don’t cause serious illness. But some kids may develop pneumonia, hepatitis (inflammation of the liver), or a rash. […] Older kids and teens who are infected may have mono-like symptoms, including tiredness, muscle aches, headache, fever, and an enlarged liver and spleen. These symptoms tend to be mild and usually last only 2 to 3 weeks. […] CMV can cause serious infections in people who have had organ transplants or those with weak immune systems. In someone with AIDS or HIV, CMV infection may affect the lungs, nervous system, gastrointestinal tract, and the eyes, sometimes causing blindness.

• #26

  https://111.wales.nhs.uk/cytomegalovirus/

  Cytomegalovirus (CMV) is a common virus that is usually harmless. Sometimes it causes problems in babies if you get it during pregnancy (congenital CMV). […] CMV does not usually cause symptoms. Some people get flu-like symptoms the first time they get CMV, including: a high temperature, aching muscles, tiredness, skin rash, feeling sick, sore throat, swollen glands. […] If you do have symptoms, they usually get better without treatment within about 3 weeks. […] Pregnant women can pass an „active” CMV infection on to their unborn baby. This is known as congenital CMV. […] If CMV is not causing symptoms, you or your baby may not need any treatment. […] Treatment weakens the virus and reduces the chance of serious problems, but it does not cure the CMV infection. […] Pregnant women who work closely with children or already have a young family are more at risk of getting CMV.

• #27 Cytomegalovirus | AAFP

  https://www.aafp.org/pubs/afp/issues/2003/0201/p519.html

  Cytomegalovirus (CMV) is a prevalent viral pathogen. The majority of persons with acute CMV will experience an inapparent infection. Primary CMV infection will cause up to 7 percent of cases of mononucleosis syndrome and will manifest symptoms almost indistinguishable from those of Epstein-Barr virus-induced mononucleosis. […] CMV-induced mononucleosis can be symptomatically indistinguishable from EBV-induced mononucleosis. Malaise, fever up to 39.4C (103.0F), chills, sore throat, headache, and fatigue can be the predominant features of both viruses. Many of the same clinical manifestations typical of EBV-induced mononucleosis (e.g., lymphadenopathy, splenomegaly, pharyngeal erythema) also can occur with CMV, although less frequently. […] Elevation of liver transaminase levels is a common feature of acute CMV infection, occurring in up to 92 percent of patients, and often it can be mistaken for acute hepatitis. In contrast to other viral causes of hepatitis, patients with CMV are anicteric, and their aspartate transaminase and alanine transaminase levels rarely go above five times their normal ranges.

• #28 Cytomegalovirus | AAFP

  https://www.aafp.org/pubs/afp/issues/2003/0201/p519.html

  Cytomegalovirus (CMV) is a prevalent viral pathogen. The majority of persons with acute CMV will experience an inapparent infection. Primary CMV infection will cause up to 7 percent of cases of mononucleosis syndrome and will manifest symptoms almost indistinguishable from those of Epstein-Barr virus-induced mononucleosis. […] CMV-induced mononucleosis can be symptomatically indistinguishable from EBV-induced mononucleosis. Malaise, fever up to 39.4C (103.0F), chills, sore throat, headache, and fatigue can be the predominant features of both viruses. Many of the same clinical manifestations typical of EBV-induced mononucleosis (e.g., lymphadenopathy, splenomegaly, pharyngeal erythema) also can occur with CMV, although less frequently. […] Elevation of liver transaminase levels is a common feature of acute CMV infection, occurring in up to 92 percent of patients, and often it can be mistaken for acute hepatitis. In contrast to other viral causes of hepatitis, patients with CMV are anicteric, and their aspartate transaminase and alanine transaminase levels rarely go above five times their normal ranges.

• #29 Cytomegalovirus (CMV) – MD Searchlight

  https://mdsearchlight.com/infectious-disease/cytomegalovirus-cmv/

  Cytomegalovirus (CMV) infection often doesn’t show symptoms, especially in individuals with a functioning immune system. The most common form this infection takes is mononucleosis, with symptoms including fever, skin rash, and an increased number of white blood cells. However, CMV mononucleosis differs from the usual mononucleosis caused by the Epstein-Barr Virus (EBV), as it often lacks pharyngeal exudate (a type of throat discharge) and heterophile antibodies. […] Other symptoms that could appear in your blood tests include anemia, abnormal liver functions, low platelet count, positive rheumatoid factor, and positive antinuclear antibody levels. Although rare, organ complications can occur. CMV becomes a significant threat to those with weakened immune systems, such as persons with HIV or those who have undergone solid organ or bone marrow transplants, where it can cause diseases specific to certain organs like the liver, lungs, and colon.

• #30 Cytomegalovirus | AAFP

  https://www.aafp.org/pubs/afp/issues/2003/0201/p519.html

  Cytomegalovirus (CMV) is a prevalent viral pathogen. The majority of persons with acute CMV will experience an inapparent infection. Primary CMV infection will cause up to 7 percent of cases of mononucleosis syndrome and will manifest symptoms almost indistinguishable from those of Epstein-Barr virus-induced mononucleosis. […] CMV-induced mononucleosis can be symptomatically indistinguishable from EBV-induced mononucleosis. Malaise, fever up to 39.4C (103.0F), chills, sore throat, headache, and fatigue can be the predominant features of both viruses. Many of the same clinical manifestations typical of EBV-induced mononucleosis (e.g., lymphadenopathy, splenomegaly, pharyngeal erythema) also can occur with CMV, although less frequently. […] Elevation of liver transaminase levels is a common feature of acute CMV infection, occurring in up to 92 percent of patients, and often it can be mistaken for acute hepatitis. In contrast to other viral causes of hepatitis, patients with CMV are anicteric, and their aspartate transaminase and alanine transaminase levels rarely go above five times their normal ranges.

• #31 Cytomegalovirus | AAFP

  https://www.aafp.org/pubs/afp/issues/2003/0201/p519.html

  Cytomegalovirus (CMV) is a prevalent viral pathogen. The majority of persons with acute CMV will experience an inapparent infection. Primary CMV infection will cause up to 7 percent of cases of mononucleosis syndrome and will manifest symptoms almost indistinguishable from those of Epstein-Barr virus-induced mononucleosis. […] CMV-induced mononucleosis can be symptomatically indistinguishable from EBV-induced mononucleosis. Malaise, fever up to 39.4C (103.0F), chills, sore throat, headache, and fatigue can be the predominant features of both viruses. Many of the same clinical manifestations typical of EBV-induced mononucleosis (e.g., lymphadenopathy, splenomegaly, pharyngeal erythema) also can occur with CMV, although less frequently. […] Elevation of liver transaminase levels is a common feature of acute CMV infection, occurring in up to 92 percent of patients, and often it can be mistaken for acute hepatitis. In contrast to other viral causes of hepatitis, patients with CMV are anicteric, and their aspartate transaminase and alanine transaminase levels rarely go above five times their normal ranges.

• #32 Cytomegalovirus – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK459185/

  Cytomegalovirus (CMV) is a wide-spread virus, with manifestations ranging from asymptomatic to severe end-organ dysfunction in immunocompromised patients with congenital CMV disease. […] CMV infection may be asymptomatic in healthy people, but it can be life-threatening in an immunocompromised patient. Congenital cytomegalovirus infection can cause morbidity and even death. After infection, CMV often remains latent, but it can reactivate at any time. Eventually, it causes mucoepidermoid carcinoma, and it may be responsible for prostate cancer. […] Primary CMV infection usually has an asymptomatic or subclinical course. Mononucleosis is the most prevalent presentation of CMV in patients with an intact immune system, characterized by fever, rash, and leukocytosis. […] In patients with a depressed immune system, CMV is more aggressive. Specific disease entities include: CMV hepatitis which may lead to fulminant liver failure, Cytomegalovirus retinitis characterized by a „pizza pie appearance” on ophthalmic exam, CMV esophagitis, Cytomegalovirus colitis, CMV pneumonitis, Polyradiculopathy, Transverse myelitis, Subacute encephalitis.

• #33 Cytomegalovirus (CMV) Infection – Infections – Merck Manual Consumer Version

  https://www.merckmanuals.com/home/infections/herpesvirus-infections/cytomegalovirus-cmv-infection

  Cytomegalovirus infection is a common herpesvirus infection with a wide range of symptoms: from no symptoms to fever and fatigue (resembling infectious mononucleosis) to severe symptoms involving the eyes, brain, or other internal organs. […] Most people have no symptoms, but some feel ill and have a fever, and people with a weakened immune system can have serious symptoms, including blindness. […] Usually, CMV infection causes no symptoms. Serious infections typically develop only in infants infected before birth and in people with a weakened immune systemfor example, people with AIDS or those who have received an organ transplant. […] A few infected people feel ill and have a fever. […] In people with a weakened immune system, CMV can cause serious disease or death. […] In people with AIDS, CMV infection is a common viral complication. The virus can infect the retina of the eye. This infection (CMV retinitis) can cause blindness.

• #34 Cytomegalovirus (CMV) | Causes, Symptoms, and Treatment

  https://patient.info/doctor/cytomegalovirus

  Cytomegalovirus (CMV) is a member of the herpesvirus family. Infection is worldwide and usually asymptomatic. CMV may cause a mononucleosis infection in healthy individuals but can cause severe illness in congenital infection and in an immunocompromised host. […] The most common disease manifestation is gastrointestinal disease. CMV pneumonia is the most serious complication but has become less common with prevention strategies for at-risk patients. Rare manifestations include retinitis and encephalitis. CMV also has an immunosuppressive effect, which can lead to an increased susceptibility to invasive bacterial and fungal disease as well as graft-versus-host disease (GvHD). […] After initial infection, human CMV remains in a persistent state within the host. Immunity against the virus controls replication, although intermittent viral shedding can still take place in the immunocompetent person.

• #35 Cytomegalovirus | AAFP

  https://www.aafp.org/pubs/afp/issues/2003/0201/p519.html

  Initial infection in newborns and reactivation of the virus in immunocompromised persons can result in severe pathology. CMV also is a serious pathogen in patients who have received an organ transplant. […] The second most common context in which a family physician will encounter the clinical sequelae of CMV infection is in patients with HIV who have a CD4 T-lymphocyte count of less than 50 per mm3 (50 106 per L). In the era before highly active antiretroviral therapy (HAART), CMV was the most common viral opportunistic infection in HIV patients. CMV-induced end-organ damage, mostly in the form of retinitis, manifested in 21 to 45 percent of such patients. […] A patient with HIV may present with a diverse variety of visual complaints secondary to CMV retinitis, including painless blurred vision, unilateral floaters, light flashes, scotoma, or the loss of central vision, depending on the location and extent of the retinal lesion. The retinitis caused by CMV is a focal necrotizing type, with or without hemorrhages. The destruction of the retina, which causes irreversible blindness, can be arrested and suppressed by anti-CMV agents. […] Patients with HIV who have low CD4 counts may experience complications from CMV involvement of the esophagus, colon, mucous membranes (ulcerative lesions and colitis), brain (meningoencephalitis), peripheral nerves (radiculopathy and myelopathy), and lungs (interstitial pneumonia).

• #36 Cytomegalovirus – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK459185/

  Cytomegalovirus (CMV) is a wide-spread virus, with manifestations ranging from asymptomatic to severe end-organ dysfunction in immunocompromised patients with congenital CMV disease. […] CMV infection may be asymptomatic in healthy people, but it can be life-threatening in an immunocompromised patient. Congenital cytomegalovirus infection can cause morbidity and even death. After infection, CMV often remains latent, but it can reactivate at any time. Eventually, it causes mucoepidermoid carcinoma, and it may be responsible for prostate cancer. […] Primary CMV infection usually has an asymptomatic or subclinical course. Mononucleosis is the most prevalent presentation of CMV in patients with an intact immune system, characterized by fever, rash, and leukocytosis. […] In patients with a depressed immune system, CMV is more aggressive. Specific disease entities include: CMV hepatitis which may lead to fulminant liver failure, Cytomegalovirus retinitis characterized by a „pizza pie appearance” on ophthalmic exam, CMV esophagitis, Cytomegalovirus colitis, CMV pneumonitis, Polyradiculopathy, Transverse myelitis, Subacute encephalitis.

• #37 Cytomegalovirus (CMV) | Causes, Symptoms, and Treatment

  https://patient.info/doctor/cytomegalovirus

  Cytomegalovirus (CMV) is a member of the herpesvirus family. Infection is worldwide and usually asymptomatic. CMV may cause a mononucleosis infection in healthy individuals but can cause severe illness in congenital infection and in an immunocompromised host. […] The most common disease manifestation is gastrointestinal disease. CMV pneumonia is the most serious complication but has become less common with prevention strategies for at-risk patients. Rare manifestations include retinitis and encephalitis. CMV also has an immunosuppressive effect, which can lead to an increased susceptibility to invasive bacterial and fungal disease as well as graft-versus-host disease (GvHD). […] After initial infection, human CMV remains in a persistent state within the host. Immunity against the virus controls replication, although intermittent viral shedding can still take place in the immunocompetent person.

• #38 Frequently Asked Questions About Cytomegalovirus Disease (CMV) | BCM

  https://www.bcm.edu/departments/pediatrics/divisions-and-centers/congenital-cmv-disease-research-clinic-registry/about-cmv/faqs

  When a person is infected with CMV any time after birth, it is known as an acquired infection. In normally healthy children and adults, CMV infection is usually not a concern. Ninety percent of the time it will not produce any signs or symptoms of infection. However, occasionally a flu-like or mononucleosis type of illness may occur and produce symptoms such as fever, sore throat, fatigue and swollen glands. […] In persons with a weakened immune system, such as patients who are infected with HIV, organ/bone marrow transplant recipients, chemotherapy/radiation patients, and people on steroid therapy, the signs and symptoms of CMV infection can be serious. Signs and symptoms can occur when an old CMV infection reactivates or when the person catches the virus for the first time. CMV infection in people with a weakened immune system puts them at risk for pneumonia, retinitis (an infection of the eye that can cause blindness), hepatitis (inflammation of the liver), esophagitis and colitis (gastrointestinal diseases), meningoencephalitis (an infection of the brain and the fluid that surrounds it), and even death.

• #39 Frequently Asked Questions About Cytomegalovirus Disease (CMV) | BCM

  https://www.bcm.edu/departments/pediatrics/divisions-and-centers/congenital-cmv-disease-research-clinic-registry/about-cmv/faqs

  When a person is infected with CMV any time after birth, it is known as an acquired infection. In normally healthy children and adults, CMV infection is usually not a concern. Ninety percent of the time it will not produce any signs or symptoms of infection. However, occasionally a flu-like or mononucleosis type of illness may occur and produce symptoms such as fever, sore throat, fatigue and swollen glands. […] In persons with a weakened immune system, such as patients who are infected with HIV, organ/bone marrow transplant recipients, chemotherapy/radiation patients, and people on steroid therapy, the signs and symptoms of CMV infection can be serious. Signs and symptoms can occur when an old CMV infection reactivates or when the person catches the virus for the first time. CMV infection in people with a weakened immune system puts them at risk for pneumonia, retinitis (an infection of the eye that can cause blindness), hepatitis (inflammation of the liver), esophagitis and colitis (gastrointestinal diseases), meningoencephalitis (an infection of the brain and the fluid that surrounds it), and even death.

• #40 Approach to the diagnosis of cytomegalovirus infection – UpToDate

  https://www.uptodate.com/contents/approach-to-the-diagnosis-of-cytomegalovirus-infection

  Cytomegalovirus (CMV) is a common infection, and, although serious disease is rare in immunocompetent individuals, CMV is a major pathogen for immunocompromised patients, including solid organ transplant recipients, hematopoietic cell transplant recipients, human immunodeficiency virus (HIV)-infected patients, and patients treated with immunomodulating drugs. […] The range of clinical disease due to CMV in immunocompromised patients is broad and includes febrile syndromes, hepatitis, pneumonitis, retinitis, encephalitis, esophagitis, and colitis. […] Since the signs and symptoms of CMV disease often overlap with other infectious processes and rejection, the diagnosis is made by integrating the clinical history, clinical presentation, and laboratory data. […] Because CMV produces lifelong latent infection, distinguishing active disease from latent infection and asymptomatic reactivation presents an additional diagnostic challenge. […] CMV infection and disease are not synonymous terms; not all patients with infection develop overt clinical disease. […] CMV infection refers to virus isolation or detection of viral proteins (antigens) or nucleic acid in any body fluid or tissue specimen regardless of symptoms or signs.

• #41 Cytomegalovirus (CMV) Infection: Causes & Symptoms

  https://my.clevelandclinic.org/health/diseases/21166-cytomegalovirus

  Swollen lymph nodes. […] Rash. […] If you have a weakened immune system (immunocompromised), you might get a new CMV infection or have a previous infection that reactivates when your body is no longer able to fight it off easily. Symptoms depend on what part of your body the virus infects and could include: […] Fever. […] Fatigue. […] CMV pneumonitis (shortness of breath, cough, muscle aches, weakness). […] CMV retinitis (blurry vision or loss of vision). […] CMV gastritis or colitis (stomach pain, blood in your poop, nausea, vomiting, diarrhea). […] CMV encephalitis (seizures, headaches, confusion). […] Congenital (present at birth) CMV is when the virus passes through the placenta to the fetus. Some babies wont have any symptoms at birth but go on to develop certain symptoms later on. Symptoms present at birth include:

• #42 Cytomegalovirus infection – Knowledge @ AMBOSS

  https://www.amboss.com/us/knowledge/cytomegalovirus-infection/

  Cytomegalovirus infection is generally asymptomatic in immunocompetent individuals but can cause mild, mononucleosis-like symptoms. […] Severe manifestations occur in patients with immunocompromise (e.g., following organ transplantation, AIDS). […] 90%: asymptomatic course. […] CMV mononucleosis: Fever, malaise, myalgia/arthralgia, fatigue, headache. […] Less common: sore throat, cervical lymphadenopathy, hepatomegaly, splenomegaly. […] Rare: severe infection with organ involvement (e.g., colitis, encephalitis). […] Asymptomatic CMV infection: evidence of viral replication (e.g., viral DNA or antigen in serum) but no symptoms. […] Viral syndrome: malaise and fever with leukopenia and/or thrombocytopenia in individuals with a positive serum CMV antigen or PCR. […] CMV pneumonia: interstitial pneumonitis; Clinical features: fever, nonproductive cough, dyspnea.

• #43 Cytomegalovirus (CMV): Practice Essentials, Background, Pathophysiology

  https://emedicine.medscape.com/article/215702-overview

  CMV pneumonia in marrow transplant recipients once carried a mortality rate higher than 85%. The use of ganciclovir plus high-dose immune globulin for the treatment of CMV pneumonia in allogeneic marrow transplant recipients has lowered the mortality rate to 30-60%. […] Because patients who develop CMV disease are immunocompromised, their prognosis may be determined by their underlying disease. The need for mechanical ventilation is a poor prognostic sign.

• #44 Cytomegalovirus (CMV) | Causes, Symptoms, and Treatment

  https://patient.info/doctor/cytomegalovirus

  Cytomegalovirus (CMV) is a member of the herpesvirus family. Infection is worldwide and usually asymptomatic. CMV may cause a mononucleosis infection in healthy individuals but can cause severe illness in congenital infection and in an immunocompromised host. […] The most common disease manifestation is gastrointestinal disease. CMV pneumonia is the most serious complication but has become less common with prevention strategies for at-risk patients. Rare manifestations include retinitis and encephalitis. CMV also has an immunosuppressive effect, which can lead to an increased susceptibility to invasive bacterial and fungal disease as well as graft-versus-host disease (GvHD). […] After initial infection, human CMV remains in a persistent state within the host. Immunity against the virus controls replication, although intermittent viral shedding can still take place in the immunocompetent person.

• #45 Cytomegalovirus (CMV) Infection: Causes & Symptoms

  https://my.clevelandclinic.org/health/diseases/21166-cytomegalovirus

  Swollen lymph nodes. […] Rash. […] If you have a weakened immune system (immunocompromised), you might get a new CMV infection or have a previous infection that reactivates when your body is no longer able to fight it off easily. Symptoms depend on what part of your body the virus infects and could include: […] Fever. […] Fatigue. […] CMV pneumonitis (shortness of breath, cough, muscle aches, weakness). […] CMV retinitis (blurry vision or loss of vision). […] CMV gastritis or colitis (stomach pain, blood in your poop, nausea, vomiting, diarrhea). […] CMV encephalitis (seizures, headaches, confusion). […] Congenital (present at birth) CMV is when the virus passes through the placenta to the fetus. Some babies wont have any symptoms at birth but go on to develop certain symptoms later on. Symptoms present at birth include:

• #46 CMV – gastroenteritis/colitis: MedlinePlus Medical EncyclopediaLock

  https://medlineplus.gov/ency/article/000667.htm

  CMV gastroenteritis/colitis is inflammation of the stomach or intestine due to infection with cytomegalovirus. […] Infection with CMV is very common. It is spread by saliva, urine, respiratory droplets, sexual contact, and blood transfusions. Most people are exposed at some point, but most of the time, the virus produces mild or no symptoms in healthy people. […] Serious CMV infections can occur in people with weakened immune systems due to: AIDS, Chemotherapy treatment for cancer, During or after bone marrow or organ transplant, Ulcerative colitis or Crohn disease. […] Gastrointestinal (GI) CMV disease may affect one area or the entire GI system. Ulcers due to CMV can occur in the esophagus, stomach, small intestine, or colon. These ulcers are associated with symptoms such as: Abdominal pain, Difficulty swallowing or pain with swallowing, Nausea, Vomiting.

• #47 Cytomegalovirus: Symptoms, treatments, and types

  https://www.medicalnewstoday.com/articles/173811

  Cytomegalovirus (CMV) is a herpes virus. Infection can cause flu-like symptoms, although it is often symptomless. In people with weakened immune systems, it can reactivate and affect the eyes, lungs, liver, and other organs. It can pass on to a fetus during pregnancy, which can lead to complications. […] The symptoms will depend on the type of CMV. […] Most people with acquired CMV have no noticeable symptoms, but if symptoms do occur, they may include: fever, night sweats, tiredness and uneasiness, sore throat, swollen glands, joint and muscle pain, low appetite and weight loss. Symptoms will generally go away after 2 weeks. […] Symptoms of recurring CMV vary, depending on which organs the virus has affected. Areas likely to be affected are the eyes, lungs, or digestive system. Symptoms may include: fever, diarrhea, gastrointestinal ulcerations, and gastrointestinal bleeding, shortness of breath, pneumonia with hypoxemia, or low blood oxygen, mouth ulcers that can be large, problems with vision, including floaters, blind spots, and blurred vision, hepatitis, or inflamed liver, with prolonged fever, encephalitis, or inflammation of the brain, leading to behavioral changes, seizures, and even coma. A person with a weakened immune system who experiences any of these symptoms should seek medical attention.

• #48 Cytomegalovirus (CMV): Symptoms, Causes, Treatment

  https://www.webmd.com/hiv-aids/aids-hiv-opportunistic-infections-cytomegalovirus

  Babies born with CMV usually look healthy when they’re born. But 1 in 5 will show signs of the infection at birth or over time. These symptoms include: Premature delivery, Small size or low birth weight, Bruise-like rashes, Yellow skin or eyes (jaundice), Swollen liver and spleen, Small head (microcephaly), Seizures, Hearing loss, Pneumonia, Liver inflammation (hepatitis), Developmental delay, Motor delay, Vision problems. […] If you also have advanced HIV, CMV can affect different parts of your body. You could have: Blind spots or moving black spots (floaters) in your eyesight, Blurry vision, Loss of central vision, Blindness, Diarrhea that may be bloody, Belly pain, Trouble swallowing or painful swallowing because of ulcers in your mouth or esophagus, Confusion, Lower back pain, Weight loss, Fatigue, Weakness in your legs, Headache, Trouble concentrating, Fever, Weight loss, Shortness of breath, Apathy, Withdrawal, Changes in personality.

• #49 Cytomegalovirus (CMV): Practice Essentials, Background, Pathophysiology

  https://emedicine.medscape.com/article/215702-overview

  Rarer manifestations of CMV infections in immunocompetent individuals include Guillain-Barr syndrome, meningoencephalitis, pericarditis, myocarditis, thrombocytopenia, and hemolytic anemia. […] CMV is an opportunistic infection in patients with advanced HIV/AIDS and can effect multiorgan systems. […] The most common sites of CMV related gastrointestinal infection are the esophagus and the colon. […] Symptoms include dry cough, shortness of breath, and fever. […] CMV hepatitis is defined as elevated bilirubin and/or liver enzymes levels in combination with the detection of CMV in the absence of other causes for hepatitis. […] Hepatitis has been commonly observed in patients with primary CMV infection and mononucleosis. […] The prognosis of CMV hepatitis generally is good. Most patients recover completely. Symptoms can persist, usually in the form of fatigue, for several months after primary infection.

• #50 Cytomegalovirus (CMV) – MD Searchlight

  https://mdsearchlight.com/infectious-disease/cytomegalovirus-cmv/

  In patients with weakened immune systems, CMV can lead to severe conditions. Here are some of the specific conditions: CMV hepatitis, which might result in complete liver failure; Cytomegalovirus retinitis, which shows a pizza pie appearance during an eye exam; CMV esophagitis; Cytomegalovirus colitis; CMV pneumonitis; Polyradiculopathy; Transverse myelitis; Subacute encephalitis. […] Signs and symptoms of Cytomegalovirus (CMV) infection include: – Fever – Skin rash – Increased number of white blood cells – Absence of pharyngeal exudate (throat discharge) and heterophile antibodies, which differentiate CMV mononucleosis from mononucleosis caused by Epstein-Barr Virus (EBV) – Anemia – Abnormal liver functions – Low platelet count – Positive rheumatoid factor – Positive antinuclear antibody levels – Rare organ complications, such as liver, lung, and colon diseases – In individuals with weakened immune systems, CMV can lead to severe conditions, including CMV hepatitis (which can result in complete liver failure), cytomegalovirus retinitis (which shows a „pizza pie appearance” during an eye exam), CMV esophagitis, cytomegalovirus colitis, CMV pneumonitis, polyradiculopathy, transverse myelitis, and subacute encephalitis.

• #51 Cytomegalovirus (CMV) Retinitis: Symptoms & Causes

  https://my.clevelandclinic.org/health/diseases/25224-cytomegalovirus-cmv-retinitis

  CMV retinitis is a serious eye condition caused by cytomegalovirus, a herpes virus. It most often affects people with compromised immune systems. Its treated with antiviral medications. […] Cytomegalovirus (CMV) retinitis is a serious eye infection. It often happens in people with immune systems that dont work as well as they should. The term retinitis means inflammation of your retina, which is the part of your eye that senses light. […] CMV retinitis can result in long-term vision loss. In fact, its the main cause of blindness among people with HIV/AIDS. […] You may not have symptoms of CMV retinitis right away. When you do develop them, symptoms may include: Floaters in your eye. Blind spots that move (scintillating scotoma). Decreased side vision (peripheral vision). Seeing wavy images (metamorphopsia). Blurred vision. Sensitivity to light (photophobia). Red eye. Eye pain.

• #52 Cytomegalovirus (CMV) Retinitis: Symptoms & Causes

  https://my.clevelandclinic.org/health/diseases/25224-cytomegalovirus-cmv-retinitis

  CMV retinitis is a serious eye condition caused by cytomegalovirus, a herpes virus. It most often affects people with compromised immune systems. Its treated with antiviral medications. […] Cytomegalovirus (CMV) retinitis is a serious eye infection. It often happens in people with immune systems that dont work as well as they should. The term retinitis means inflammation of your retina, which is the part of your eye that senses light. […] CMV retinitis can result in long-term vision loss. In fact, its the main cause of blindness among people with HIV/AIDS. […] You may not have symptoms of CMV retinitis right away. When you do develop them, symptoms may include: Floaters in your eye. Blind spots that move (scintillating scotoma). Decreased side vision (peripheral vision). Seeing wavy images (metamorphopsia). Blurred vision. Sensitivity to light (photophobia). Red eye. Eye pain.

• #53 Cytomegalovirus – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK459185/

  Cytomegalovirus (CMV) is a wide-spread virus, with manifestations ranging from asymptomatic to severe end-organ dysfunction in immunocompromised patients with congenital CMV disease. […] CMV infection may be asymptomatic in healthy people, but it can be life-threatening in an immunocompromised patient. Congenital cytomegalovirus infection can cause morbidity and even death. After infection, CMV often remains latent, but it can reactivate at any time. Eventually, it causes mucoepidermoid carcinoma, and it may be responsible for prostate cancer. […] Primary CMV infection usually has an asymptomatic or subclinical course. Mononucleosis is the most prevalent presentation of CMV in patients with an intact immune system, characterized by fever, rash, and leukocytosis. […] In patients with a depressed immune system, CMV is more aggressive. Specific disease entities include: CMV hepatitis which may lead to fulminant liver failure, Cytomegalovirus retinitis characterized by a „pizza pie appearance” on ophthalmic exam, CMV esophagitis, Cytomegalovirus colitis, CMV pneumonitis, Polyradiculopathy, Transverse myelitis, Subacute encephalitis.

• #54 Cytomegalovirus (CMV) Infection: Causes & Symptoms

  https://my.clevelandclinic.org/health/diseases/21166-cytomegalovirus

  Swollen lymph nodes. […] Rash. […] If you have a weakened immune system (immunocompromised), you might get a new CMV infection or have a previous infection that reactivates when your body is no longer able to fight it off easily. Symptoms depend on what part of your body the virus infects and could include: […] Fever. […] Fatigue. […] CMV pneumonitis (shortness of breath, cough, muscle aches, weakness). […] CMV retinitis (blurry vision or loss of vision). […] CMV gastritis or colitis (stomach pain, blood in your poop, nausea, vomiting, diarrhea). […] CMV encephalitis (seizures, headaches, confusion). […] Congenital (present at birth) CMV is when the virus passes through the placenta to the fetus. Some babies wont have any symptoms at birth but go on to develop certain symptoms later on. Symptoms present at birth include:

• #55 Cytomegalovirus: Symptoms, treatments, and types

  https://www.medicalnewstoday.com/articles/173811

  Cytomegalovirus (CMV) is a herpes virus. Infection can cause flu-like symptoms, although it is often symptomless. In people with weakened immune systems, it can reactivate and affect the eyes, lungs, liver, and other organs. It can pass on to a fetus during pregnancy, which can lead to complications. […] The symptoms will depend on the type of CMV. […] Most people with acquired CMV have no noticeable symptoms, but if symptoms do occur, they may include: fever, night sweats, tiredness and uneasiness, sore throat, swollen glands, joint and muscle pain, low appetite and weight loss. Symptoms will generally go away after 2 weeks. […] Symptoms of recurring CMV vary, depending on which organs the virus has affected. Areas likely to be affected are the eyes, lungs, or digestive system. Symptoms may include: fever, diarrhea, gastrointestinal ulcerations, and gastrointestinal bleeding, shortness of breath, pneumonia with hypoxemia, or low blood oxygen, mouth ulcers that can be large, problems with vision, including floaters, blind spots, and blurred vision, hepatitis, or inflamed liver, with prolonged fever, encephalitis, or inflammation of the brain, leading to behavioral changes, seizures, and even coma. A person with a weakened immune system who experiences any of these symptoms should seek medical attention.

• #56 Cytomegalovirus – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK459185/

  Cytomegalovirus (CMV) is a wide-spread virus, with manifestations ranging from asymptomatic to severe end-organ dysfunction in immunocompromised patients with congenital CMV disease. […] CMV infection may be asymptomatic in healthy people, but it can be life-threatening in an immunocompromised patient. Congenital cytomegalovirus infection can cause morbidity and even death. After infection, CMV often remains latent, but it can reactivate at any time. Eventually, it causes mucoepidermoid carcinoma, and it may be responsible for prostate cancer. […] Primary CMV infection usually has an asymptomatic or subclinical course. Mononucleosis is the most prevalent presentation of CMV in patients with an intact immune system, characterized by fever, rash, and leukocytosis. […] In patients with a depressed immune system, CMV is more aggressive. Specific disease entities include: CMV hepatitis which may lead to fulminant liver failure, Cytomegalovirus retinitis characterized by a „pizza pie appearance” on ophthalmic exam, CMV esophagitis, Cytomegalovirus colitis, CMV pneumonitis, Polyradiculopathy, Transverse myelitis, Subacute encephalitis.

• #57 Cytomegalovirus (CMV): Symptoms, Causes, Treatment

  https://www.webmd.com/hiv-aids/aids-hiv-opportunistic-infections-cytomegalovirus

  Babies born with CMV usually look healthy when they’re born. But 1 in 5 will show signs of the infection at birth or over time. These symptoms include: Premature delivery, Small size or low birth weight, Bruise-like rashes, Yellow skin or eyes (jaundice), Swollen liver and spleen, Small head (microcephaly), Seizures, Hearing loss, Pneumonia, Liver inflammation (hepatitis), Developmental delay, Motor delay, Vision problems. […] If you also have advanced HIV, CMV can affect different parts of your body. You could have: Blind spots or moving black spots (floaters) in your eyesight, Blurry vision, Loss of central vision, Blindness, Diarrhea that may be bloody, Belly pain, Trouble swallowing or painful swallowing because of ulcers in your mouth or esophagus, Confusion, Lower back pain, Weight loss, Fatigue, Weakness in your legs, Headache, Trouble concentrating, Fever, Weight loss, Shortness of breath, Apathy, Withdrawal, Changes in personality.

• #58 About Cytomegalovirus | Cytomegalovirus (CMV) and Congenital CMV Infection | CDC

  https://www.cdc.gov/cytomegalovirus/about/index.html

  Most people with CMV show no signs or symptoms and arent aware that they have been infected. […] Sometimes, infection in healthy people can cause mild illness like: Fever, Sore throat, Fatigue, Swollen glands. […] Occasionally, CMV can cause mononucleosis or hepatitis (liver problems). […] If you have a weakened immune system and get CMV, you can have more serious symptoms affecting the eyes; lungs; liver; esophagus; stomach; and intestines. […] Babies born with CMV can have brain, liver, spleen, lung, and growth problems. The most common long-term health problem in babies born with CMV infection is hearing loss. This may be detected soon after birth or may develop later in childhood. […] About 1 in 200 babies is born with congenital CMV infection. About 1 in 5 babies with congenital CMV infection will have birth defects or other long-term health problems.

• #59 Cytomegalovirus | Boston Children’s Hospital

  https://www.childrenshospital.org/conditions/cytomegalovirus

  Cytomegalovirus (CMV) is a virus related to the herpes virus group of infections. Like herpes, it is inactive at times, but it is an incurable life-time infection. CMV is a major concern if a mother becomes first infected while pregnant. […] Symptoms of a CMV infection may look similar to mononucleosis (fever, swollen glands, constant fatigue, tonsillitis, liver malfunction). […] Most people who have CMV aren’t aware of it because the virus rarely produces symptoms. The biggest concern is for people who have weak immune systems and women who become infected while pregnant. […] About 5 to 10 percent of babies with congenital CMV will have signs of the infection at birth. Of these, over 90 percent will have serious complications including hearing loss, visual impairment, mental retardation, autism, attention deficit/hyperactivity disorder, epilepsy, or sometimes death.

• #60 Cytomegalovirus (CMV) in Pregnancy | ACOG

  https://www.acog.org/clinical-information/physician-faqs/cytomegalovirus-in-pregnancy

  With primary maternal CMV infection, the overall risk of transmission to the fetus is approximately 30-40%. Transmission rates for primary infection are 30% in the first trimester, 34-38% in the second trimester, and 40-72% in the third trimester. Vertical transmission after a recurrent infection is approximately 0.15-2%. Infants infected after maternal CMV reactivation generally are asymptomatic at birth. Congenital hearing loss is typically the most severe sequela of secondary infection, and congenital infection after recurrent infection is unlikely to produce severe sequelae.

• #61 Cytomegalovirus (CMV) in Pregnancy | ACOG

  https://www.acog.org/clinical-information/physician-faqs/cytomegalovirus-in-pregnancy

  With primary maternal CMV infection, the overall risk of transmission to the fetus is approximately 30-40%. Transmission rates for primary infection are 30% in the first trimester, 34-38% in the second trimester, and 40-72% in the third trimester. Vertical transmission after a recurrent infection is approximately 0.15-2%. Infants infected after maternal CMV reactivation generally are asymptomatic at birth. Congenital hearing loss is typically the most severe sequela of secondary infection, and congenital infection after recurrent infection is unlikely to produce severe sequelae.

• #62 Cytomegalovirus or CMV | Texas Children’s

  https://www.texaschildrens.org/content/conditions/cytomegalovirus-or-cmv

  Cytomegalovirus or CMV is a common virus that infects almost everyone at some time in their life. Most infections with CMV are “silent” and cause no signs or symptoms. If CMV causes symptoms it usually is fever, fatigue, and aches or a mononucelosis “mono” syndrome. CMV may cause severe illness and damage to organs and vision in people whose immune systems are low. […] Most people with CMV have no symptoms and never know they’ve been infected. Others have a mild flu-like illness or mononucleosis, with symptoms that may include: Fever, Headache, Sore throat, Swollen lymph glands, Muscle aches, Tiredness, Rash. […] Healthy babies may be born with silent congenital CMV and have no symptoms. Some babies with congenital CMV will have deafness at birth. More severely affected newborns with congenital CMV may have rash, enlarged liver and spleen, vision problems, or abnormalities of their brain development, such as microcephaly (small head), calcifications, or polymicrogyria (PMG). […] Most newborns with CMV are normal, but some newborns may have serious disease from CMV.

• #63 Cytomegalovirus (CMV) in Pregnancy: Symptoms, Causes & Treatment

  https://www.whattoexpect.com/pregnancy/pregnancy-health/complications/cytomegalovirus.aspx

  About 1 in 200 babies is born with congenital CMV (or a CMV infection at birth). Of the approximately 1 to 4% of people who get CMV during pregnancy, about 1 in 3 pass the infection on to their babies. […] Even if you do pass CMV on to your baby during pregnancy, most babies born with the virus don’t have health problems. In all, about 1 in 5 babies with congenital CMV have birth defects or other long-term problems. Research suggests about 80 to 90% of babies with congenital CMV are asymptomatic at birth and have very low chances of long-term complications. The odds of long-term complications increase significantly in babies who are infected early on in pregnancy and in newborns who experience symptoms at birth. […] Although CMV often comes and goes without any obvious symptoms, you may experience the following signs of CMV: Fever that lasts a few days, Constant, persistent fatigue, Swollen glands, Sore throat. […] Rarely, CMV can lead to mononucleosis (a condition caused by certain viruses that causes extreme fatigue among other symptoms).

• #64 Clinical Overview of CMV and Congenital CMV | Cytomegalovirus (CMV) and Congenital CMV Infection | CDC

  https://www.cdc.gov/cytomegalovirus/hcp/clinical-overview/index.html

  Most healthy people, children, and infants who acquire CMV after birth have few symptoms and no long-term health complications from infection. […] Some people who acquire CMV infection may experience a mononucleosis-like condition with prolonged fever and hepatitis. […] Most infants born with CMV infection never have health problems. About 10% of infants with congenital CMV infection will have signs at birth, which include: Petechiae/purpura (blood spots), Jaundice (yellowing of the skin or whites of the eyes), Microcephaly (small head), Intrauterine growth (low birth weight), Hepatosplenomegaly (enlarged liver and spleen), Seizures, Retinitis (damaged eye retina). […] About 40 to 60% of infants born with signs of congenital CMV disease at birth will have long-term health problems. These can be: Hearing loss, Developmental and motor delay, Vision loss, Microcephaly (small head), Lack of coordination or weakness, Seizures. […] Some babies may have hearing loss that may or may not be detected by newborn hearing test.

• #65 Cytomegalovirus | Boston Children’s Hospital

  https://www.childrenshospital.org/conditions/cytomegalovirus

  Most babies with congenital CMV do not have symptoms of the infection at birth. However, each baby may experience symptoms differently. Symptoms may include: Premature birth, Low birth weight, Liver enlargement and jaundice, Spleen enlargement, Lung infection, Anemia, Purple skin blotches and/or rashes, Seizures, Hearing loss. […] Children with a CMV infection may receive: The anti-viral medication ganciclovir, CMV-Ig, which contains CMV antibodies from a blood donor. Data suggests these anti-viral agents can reduce hearing loss, CMV-related hepatitis, and CMV-related gastroenteritis in newborns.

• #66 Cytomegalovirus | Boston Children’s Hospital

  https://www.childrenshospital.org/conditions/cytomegalovirus

  Most babies with congenital CMV do not have symptoms of the infection at birth. However, each baby may experience symptoms differently. Symptoms may include: Premature birth, Low birth weight, Liver enlargement and jaundice, Spleen enlargement, Lung infection, Anemia, Purple skin blotches and/or rashes, Seizures, Hearing loss. […] Children with a CMV infection may receive: The anti-viral medication ganciclovir, CMV-Ig, which contains CMV antibodies from a blood donor. Data suggests these anti-viral agents can reduce hearing loss, CMV-related hepatitis, and CMV-related gastroenteritis in newborns.

• #67 Clinical Overview of CMV and Congenital CMV | Cytomegalovirus (CMV) and Congenital CMV Infection | CDC

  https://www.cdc.gov/cytomegalovirus/hcp/clinical-overview/index.html

  Most healthy people, children, and infants who acquire CMV after birth have few symptoms and no long-term health complications from infection. […] Some people who acquire CMV infection may experience a mononucleosis-like condition with prolonged fever and hepatitis. […] Most infants born with CMV infection never have health problems. About 10% of infants with congenital CMV infection will have signs at birth, which include: Petechiae/purpura (blood spots), Jaundice (yellowing of the skin or whites of the eyes), Microcephaly (small head), Intrauterine growth (low birth weight), Hepatosplenomegaly (enlarged liver and spleen), Seizures, Retinitis (damaged eye retina). […] About 40 to 60% of infants born with signs of congenital CMV disease at birth will have long-term health problems. These can be: Hearing loss, Developmental and motor delay, Vision loss, Microcephaly (small head), Lack of coordination or weakness, Seizures. […] Some babies may have hearing loss that may or may not be detected by newborn hearing test.

• #68 Clinical Overview of CMV and Congenital CMV | Cytomegalovirus (CMV) and Congenital CMV Infection | CDC

  https://www.cdc.gov/cytomegalovirus/hcp/clinical-overview/index.html

  Most healthy people, children, and infants who acquire CMV after birth have few symptoms and no long-term health complications from infection. […] Some people who acquire CMV infection may experience a mononucleosis-like condition with prolonged fever and hepatitis. […] Most infants born with CMV infection never have health problems. About 10% of infants with congenital CMV infection will have signs at birth, which include: Petechiae/purpura (blood spots), Jaundice (yellowing of the skin or whites of the eyes), Microcephaly (small head), Intrauterine growth (low birth weight), Hepatosplenomegaly (enlarged liver and spleen), Seizures, Retinitis (damaged eye retina). […] About 40 to 60% of infants born with signs of congenital CMV disease at birth will have long-term health problems. These can be: Hearing loss, Developmental and motor delay, Vision loss, Microcephaly (small head), Lack of coordination or weakness, Seizures. […] Some babies may have hearing loss that may or may not be detected by newborn hearing test.

• #69 Cytomegalovirus | Boston Children’s Hospital

  https://www.childrenshospital.org/conditions/cytomegalovirus

  Most babies with congenital CMV do not have symptoms of the infection at birth. However, each baby may experience symptoms differently. Symptoms may include: Premature birth, Low birth weight, Liver enlargement and jaundice, Spleen enlargement, Lung infection, Anemia, Purple skin blotches and/or rashes, Seizures, Hearing loss. […] Children with a CMV infection may receive: The anti-viral medication ganciclovir, CMV-Ig, which contains CMV antibodies from a blood donor. Data suggests these anti-viral agents can reduce hearing loss, CMV-related hepatitis, and CMV-related gastroenteritis in newborns.

• #70 Clinical Overview of CMV and Congenital CMV | Cytomegalovirus (CMV) and Congenital CMV Infection | CDC

  https://www.cdc.gov/cytomegalovirus/hcp/clinical-overview/index.html

  Most healthy people, children, and infants who acquire CMV after birth have few symptoms and no long-term health complications from infection. […] Some people who acquire CMV infection may experience a mononucleosis-like condition with prolonged fever and hepatitis. […] Most infants born with CMV infection never have health problems. About 10% of infants with congenital CMV infection will have signs at birth, which include: Petechiae/purpura (blood spots), Jaundice (yellowing of the skin or whites of the eyes), Microcephaly (small head), Intrauterine growth (low birth weight), Hepatosplenomegaly (enlarged liver and spleen), Seizures, Retinitis (damaged eye retina). […] About 40 to 60% of infants born with signs of congenital CMV disease at birth will have long-term health problems. These can be: Hearing loss, Developmental and motor delay, Vision loss, Microcephaly (small head), Lack of coordination or weakness, Seizures. […] Some babies may have hearing loss that may or may not be detected by newborn hearing test.

• #71 Cytomegalovirus | Boston Children’s Hospital

  https://www.childrenshospital.org/conditions/cytomegalovirus

  Most babies with congenital CMV do not have symptoms of the infection at birth. However, each baby may experience symptoms differently. Symptoms may include: Premature birth, Low birth weight, Liver enlargement and jaundice, Spleen enlargement, Lung infection, Anemia, Purple skin blotches and/or rashes, Seizures, Hearing loss. […] Children with a CMV infection may receive: The anti-viral medication ganciclovir, CMV-Ig, which contains CMV antibodies from a blood donor. Data suggests these anti-viral agents can reduce hearing loss, CMV-related hepatitis, and CMV-related gastroenteritis in newborns.

• #72 Cytomegalovirus | Boston Children’s Hospital

  https://www.childrenshospital.org/conditions/cytomegalovirus

  Most babies with congenital CMV do not have symptoms of the infection at birth. However, each baby may experience symptoms differently. Symptoms may include: Premature birth, Low birth weight, Liver enlargement and jaundice, Spleen enlargement, Lung infection, Anemia, Purple skin blotches and/or rashes, Seizures, Hearing loss. […] Children with a CMV infection may receive: The anti-viral medication ganciclovir, CMV-Ig, which contains CMV antibodies from a blood donor. Data suggests these anti-viral agents can reduce hearing loss, CMV-related hepatitis, and CMV-related gastroenteritis in newborns.

• #73 Clinical Overview of CMV and Congenital CMV | Cytomegalovirus (CMV) and Congenital CMV Infection | CDC

  https://www.cdc.gov/cytomegalovirus/hcp/clinical-overview/index.html

  Most healthy people, children, and infants who acquire CMV after birth have few symptoms and no long-term health complications from infection. […] Some people who acquire CMV infection may experience a mononucleosis-like condition with prolonged fever and hepatitis. […] Most infants born with CMV infection never have health problems. About 10% of infants with congenital CMV infection will have signs at birth, which include: Petechiae/purpura (blood spots), Jaundice (yellowing of the skin or whites of the eyes), Microcephaly (small head), Intrauterine growth (low birth weight), Hepatosplenomegaly (enlarged liver and spleen), Seizures, Retinitis (damaged eye retina). […] About 40 to 60% of infants born with signs of congenital CMV disease at birth will have long-term health problems. These can be: Hearing loss, Developmental and motor delay, Vision loss, Microcephaly (small head), Lack of coordination or weakness, Seizures. […] Some babies may have hearing loss that may or may not be detected by newborn hearing test.

• #74 Clinical Overview of CMV and Congenital CMV | Cytomegalovirus (CMV) and Congenital CMV Infection | CDC

  https://www.cdc.gov/cytomegalovirus/hcp/clinical-overview/index.html

  Most healthy people, children, and infants who acquire CMV after birth have few symptoms and no long-term health complications from infection. […] Some people who acquire CMV infection may experience a mononucleosis-like condition with prolonged fever and hepatitis. […] Most infants born with CMV infection never have health problems. About 10% of infants with congenital CMV infection will have signs at birth, which include: Petechiae/purpura (blood spots), Jaundice (yellowing of the skin or whites of the eyes), Microcephaly (small head), Intrauterine growth (low birth weight), Hepatosplenomegaly (enlarged liver and spleen), Seizures, Retinitis (damaged eye retina). […] About 40 to 60% of infants born with signs of congenital CMV disease at birth will have long-term health problems. These can be: Hearing loss, Developmental and motor delay, Vision loss, Microcephaly (small head), Lack of coordination or weakness, Seizures. […] Some babies may have hearing loss that may or may not be detected by newborn hearing test.

• #75 Cytomegalovirus | Boston Children’s Hospital

  https://www.childrenshospital.org/conditions/cytomegalovirus

  Most babies with congenital CMV do not have symptoms of the infection at birth. However, each baby may experience symptoms differently. Symptoms may include: Premature birth, Low birth weight, Liver enlargement and jaundice, Spleen enlargement, Lung infection, Anemia, Purple skin blotches and/or rashes, Seizures, Hearing loss. […] Children with a CMV infection may receive: The anti-viral medication ganciclovir, CMV-Ig, which contains CMV antibodies from a blood donor. Data suggests these anti-viral agents can reduce hearing loss, CMV-related hepatitis, and CMV-related gastroenteritis in newborns.

• #76 Clinical Overview of CMV and Congenital CMV | Cytomegalovirus (CMV) and Congenital CMV Infection | CDC

  https://www.cdc.gov/cytomegalovirus/hcp/clinical-overview/index.html

  Most healthy people, children, and infants who acquire CMV after birth have few symptoms and no long-term health complications from infection. […] Some people who acquire CMV infection may experience a mononucleosis-like condition with prolonged fever and hepatitis. […] Most infants born with CMV infection never have health problems. About 10% of infants with congenital CMV infection will have signs at birth, which include: Petechiae/purpura (blood spots), Jaundice (yellowing of the skin or whites of the eyes), Microcephaly (small head), Intrauterine growth (low birth weight), Hepatosplenomegaly (enlarged liver and spleen), Seizures, Retinitis (damaged eye retina). […] About 40 to 60% of infants born with signs of congenital CMV disease at birth will have long-term health problems. These can be: Hearing loss, Developmental and motor delay, Vision loss, Microcephaly (small head), Lack of coordination or weakness, Seizures. […] Some babies may have hearing loss that may or may not be detected by newborn hearing test.

• #77 Cytomegalovirus | Boston Children’s Hospital

  https://www.childrenshospital.org/conditions/cytomegalovirus

  Most babies with congenital CMV do not have symptoms of the infection at birth. However, each baby may experience symptoms differently. Symptoms may include: Premature birth, Low birth weight, Liver enlargement and jaundice, Spleen enlargement, Lung infection, Anemia, Purple skin blotches and/or rashes, Seizures, Hearing loss. […] Children with a CMV infection may receive: The anti-viral medication ganciclovir, CMV-Ig, which contains CMV antibodies from a blood donor. Data suggests these anti-viral agents can reduce hearing loss, CMV-related hepatitis, and CMV-related gastroenteritis in newborns.

• #78 Clinical Overview of CMV and Congenital CMV | Cytomegalovirus (CMV) and Congenital CMV Infection | CDC

  https://www.cdc.gov/cytomegalovirus/hcp/clinical-overview/index.html

  Most healthy people, children, and infants who acquire CMV after birth have few symptoms and no long-term health complications from infection. […] Some people who acquire CMV infection may experience a mononucleosis-like condition with prolonged fever and hepatitis. […] Most infants born with CMV infection never have health problems. About 10% of infants with congenital CMV infection will have signs at birth, which include: Petechiae/purpura (blood spots), Jaundice (yellowing of the skin or whites of the eyes), Microcephaly (small head), Intrauterine growth (low birth weight), Hepatosplenomegaly (enlarged liver and spleen), Seizures, Retinitis (damaged eye retina). […] About 40 to 60% of infants born with signs of congenital CMV disease at birth will have long-term health problems. These can be: Hearing loss, Developmental and motor delay, Vision loss, Microcephaly (small head), Lack of coordination or weakness, Seizures. […] Some babies may have hearing loss that may or may not be detected by newborn hearing test.

• #79 Cytomegalovirus | Boston Children’s Hospital

  https://www.childrenshospital.org/conditions/cytomegalovirus

  Most babies with congenital CMV do not have symptoms of the infection at birth. However, each baby may experience symptoms differently. Symptoms may include: Premature birth, Low birth weight, Liver enlargement and jaundice, Spleen enlargement, Lung infection, Anemia, Purple skin blotches and/or rashes, Seizures, Hearing loss. […] Children with a CMV infection may receive: The anti-viral medication ganciclovir, CMV-Ig, which contains CMV antibodies from a blood donor. Data suggests these anti-viral agents can reduce hearing loss, CMV-related hepatitis, and CMV-related gastroenteritis in newborns.

• #80 Cytomegalovirus | Boston Children’s Hospital

  https://www.childrenshospital.org/conditions/cytomegalovirus

  Most babies with congenital CMV do not have symptoms of the infection at birth. However, each baby may experience symptoms differently. Symptoms may include: Premature birth, Low birth weight, Liver enlargement and jaundice, Spleen enlargement, Lung infection, Anemia, Purple skin blotches and/or rashes, Seizures, Hearing loss. […] Children with a CMV infection may receive: The anti-viral medication ganciclovir, CMV-Ig, which contains CMV antibodies from a blood donor. Data suggests these anti-viral agents can reduce hearing loss, CMV-related hepatitis, and CMV-related gastroenteritis in newborns.

• #81 Clinical Overview of CMV and Congenital CMV | Cytomegalovirus (CMV) and Congenital CMV Infection | CDC

  https://www.cdc.gov/cytomegalovirus/hcp/clinical-overview/index.html

  Most healthy people, children, and infants who acquire CMV after birth have few symptoms and no long-term health complications from infection. […] Some people who acquire CMV infection may experience a mononucleosis-like condition with prolonged fever and hepatitis. […] Most infants born with CMV infection never have health problems. About 10% of infants with congenital CMV infection will have signs at birth, which include: Petechiae/purpura (blood spots), Jaundice (yellowing of the skin or whites of the eyes), Microcephaly (small head), Intrauterine growth (low birth weight), Hepatosplenomegaly (enlarged liver and spleen), Seizures, Retinitis (damaged eye retina). […] About 40 to 60% of infants born with signs of congenital CMV disease at birth will have long-term health problems. These can be: Hearing loss, Developmental and motor delay, Vision loss, Microcephaly (small head), Lack of coordination or weakness, Seizures. […] Some babies may have hearing loss that may or may not be detected by newborn hearing test.

• #82 Cytomegalovirus (CMV) Infection in Newborns – Children’s Health Issues – Merck Manual Consumer Version

  https://www.merckmanuals.com/home/children-s-health-issues/infections-in-newborns/cytomegalovirus-cmv-infection-in-newborns

  Some newborns have all of these symptoms. […] CMV infection is fatal in 5 to 10% of newborns who have symptoms. Most of the infants who have symptoms who survive develop hearing loss. […] About 5 to 15% of newborns who do not have symptoms eventually develop neurologic problems (most commonly hearing loss). Some degree of hearing loss is the most common.

• #83 Clinical Overview of CMV and Congenital CMV | Cytomegalovirus (CMV) and Congenital CMV Infection | CDC

  https://www.cdc.gov/cytomegalovirus/hcp/clinical-overview/index.html

  Most healthy people, children, and infants who acquire CMV after birth have few symptoms and no long-term health complications from infection. […] Some people who acquire CMV infection may experience a mononucleosis-like condition with prolonged fever and hepatitis. […] Most infants born with CMV infection never have health problems. About 10% of infants with congenital CMV infection will have signs at birth, which include: Petechiae/purpura (blood spots), Jaundice (yellowing of the skin or whites of the eyes), Microcephaly (small head), Intrauterine growth (low birth weight), Hepatosplenomegaly (enlarged liver and spleen), Seizures, Retinitis (damaged eye retina). […] About 40 to 60% of infants born with signs of congenital CMV disease at birth will have long-term health problems. These can be: Hearing loss, Developmental and motor delay, Vision loss, Microcephaly (small head), Lack of coordination or weakness, Seizures. […] Some babies may have hearing loss that may or may not be detected by newborn hearing test.

• #84 Congenital Cytomegalovirus (CMV) Infection – American Academy of Audiology

  https://www.audiology.org/consumers-and-patients/hearing-and-balance/congenital-cytomegalovirus-cmv-infection/

  One in every 200 babies are born with Congenital Cytomegalovirus (CMV) Infection.1 […] One in five of these babies will have long-term health problems.1 […] CMV is a common virus that can infect people of all ages. […] Usually there are no signs or symptoms. In some cases, a mild illness including fever, sore throat, fatigue, and swollen glands may happen. […] Infants with congenital CMV may be at risk for long-term health concerns. […] Children with congenital CMV can be asymptomatic or symptomatic at birth. […] Most children are asymptomatic, meaning that they do not have significant health problems. […] Children with symptomatic CMV may have many symptoms present at birth or have symptoms that develop in early childhood. […] Common signs include: Premature birth, Problems with the liver, lungs, spleen, Small size at birth, Small head size, Seizures.

• #85 Congenital cytomegalovirus infection – Wikipedia

  https://en.wikipedia.org/wiki/Congenital_cytomegalovirus_infection

  Another 5% to 10% of infants who are infected but without symptoms at birth will subsequently have varying degrees of hearing and mental or coordination problems. CMV is the most common cause of non-genetic sensorineural hearing loss in children. The onset of hearing loss can occur at any point during childhood, although commonly within the first decade. It is progressive and can affect both ears. […] Symptoms associated with CMV, such as hearing loss, can result in further developmental delay. A delay in general speech and language development is more common in children with CMV. Children with symptomatic CMV have been found to have a greater incidence of long-term neurological and neurodevelopmental complications than children with fetal alcohol syndrome or down syndrome. […] Congenital cytomegalovirus infection can be an important cause of intraventricular hemorrhage and neonatal encephalopathy.

• #86 Clinical Overview of CMV and Congenital CMV | Cytomegalovirus (CMV) and Congenital CMV Infection | CDC

  https://www.cdc.gov/cytomegalovirus/hcp/clinical-overview/index.html

  Most healthy people, children, and infants who acquire CMV after birth have few symptoms and no long-term health complications from infection. […] Some people who acquire CMV infection may experience a mononucleosis-like condition with prolonged fever and hepatitis. […] Most infants born with CMV infection never have health problems. About 10% of infants with congenital CMV infection will have signs at birth, which include: Petechiae/purpura (blood spots), Jaundice (yellowing of the skin or whites of the eyes), Microcephaly (small head), Intrauterine growth (low birth weight), Hepatosplenomegaly (enlarged liver and spleen), Seizures, Retinitis (damaged eye retina). […] About 40 to 60% of infants born with signs of congenital CMV disease at birth will have long-term health problems. These can be: Hearing loss, Developmental and motor delay, Vision loss, Microcephaly (small head), Lack of coordination or weakness, Seizures. […] Some babies may have hearing loss that may or may not be detected by newborn hearing test.

• #87 Cytomegalovirus (CMV) in Pregnancy: Symptoms, Causes & Treatment

  https://www.whattoexpect.com/pregnancy/pregnancy-health/complications/cytomegalovirus.aspx

  The majority of babies who are infected with CMV during pregnancy never show any signs of infection at birth. For the few who do, symptoms may include: Seizures, Small head size (microcephaly), Small size at birth, Liver, spleen and lung problems, Damaged retinas. […] A small percentage of babies with no symptoms at birth may show more serious effects later in life, including: Learning and motor disabilities, Vision or hearing loss (CMV transmitted before birth is the leading cause of hearing loss in children), Seizures. […] Women who have not been infected with CMV before pregnancy are most at risk (though it can be hard to know if that’s you, since symptoms are so similar to other viral infections). The most serious problems from CMV infection are likely to occur earlier in pregnancy, particularly the first trimester so it’s an especially good idea to take extra hygiene precautions during that time.

• #88 Cytomegalovirus (CMV) in Pregnancy: Symptoms, Causes & Treatment

  https://www.whattoexpect.com/pregnancy/pregnancy-health/complications/cytomegalovirus.aspx

  The majority of babies who are infected with CMV during pregnancy never show any signs of infection at birth. For the few who do, symptoms may include: Seizures, Small head size (microcephaly), Small size at birth, Liver, spleen and lung problems, Damaged retinas. […] A small percentage of babies with no symptoms at birth may show more serious effects later in life, including: Learning and motor disabilities, Vision or hearing loss (CMV transmitted before birth is the leading cause of hearing loss in children), Seizures. […] Women who have not been infected with CMV before pregnancy are most at risk (though it can be hard to know if that’s you, since symptoms are so similar to other viral infections). The most serious problems from CMV infection are likely to occur earlier in pregnancy, particularly the first trimester so it’s an especially good idea to take extra hygiene precautions during that time.

• #89 Cytomegalovirus: Symptoms, treatments, and types

  https://www.medicalnewstoday.com/articles/173811

  According to the National CMV Foundation, around 90% of babies born with CMV have no symptoms, but 10-15% of them will develop hearing loss, typically during their first 6 months of life. The severity ranges from slight to total hearing loss. […] If there are symptoms of congenital CMV at birth, they may include: jaundice, pneumonia, spots under the skin, purple skin splotches, a rash, or both, enlarged liver, enlarged spleen, low birth weight, seizures. Some of these symptoms are treatable. […] CMV will impact the brain in about 75% of babies born with congenital CMV. This may lead to challenges later in life. Conditions that they may face include: autism, central vision loss, scarring of the retina, and uveitis, or swelling and irritation of the eye, cognitive and learning difficulties, deafness or partial hearing loss, epilepsy, impaired vision, problems with physical coordination, seizures, small head. […] The symptoms may be severe, and they include vision and hearing loss, small head size, weakness, difficulty using muscles, coordination problems, and seizures.

• #90 Clinical Overview of CMV and Congenital CMV | Cytomegalovirus (CMV) and Congenital CMV Infection | CDC

  https://www.cdc.gov/cytomegalovirus/hcp/clinical-overview/index.html

  Most healthy people, children, and infants who acquire CMV after birth have few symptoms and no long-term health complications from infection. […] Some people who acquire CMV infection may experience a mononucleosis-like condition with prolonged fever and hepatitis. […] Most infants born with CMV infection never have health problems. About 10% of infants with congenital CMV infection will have signs at birth, which include: Petechiae/purpura (blood spots), Jaundice (yellowing of the skin or whites of the eyes), Microcephaly (small head), Intrauterine growth (low birth weight), Hepatosplenomegaly (enlarged liver and spleen), Seizures, Retinitis (damaged eye retina). […] About 40 to 60% of infants born with signs of congenital CMV disease at birth will have long-term health problems. These can be: Hearing loss, Developmental and motor delay, Vision loss, Microcephaly (small head), Lack of coordination or weakness, Seizures. […] Some babies may have hearing loss that may or may not be detected by newborn hearing test.

• #91 Cytomegalovirus (CMV) infection – Symptoms & causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/cmv/symptoms-causes/syc-20355358

  Most babies who have congenital CMV appear healthy at birth. A few babies who have congenital CMV who appear healthy at birth develop signs over time sometimes not for months or years after birth. The most common of these late-occurring signs are hearing loss and developmental delay. A small number of babies may also develop vision problems. […] If your immune system is weakened, you might experience serious problems that affect your: Eyes, Lungs, Liver, Esophagus, Stomach, Intestines, Brain. […] Most people who are infected with CMV who are otherwise healthy experience few if any symptoms. When first infected, some adults may have symptoms similar to infectious mononucleosis, including: Fatigue, Fever, Sore throat, Muscle aches. […] See your doctor if: You have a weakened immune system and you’re experiencing symptoms of CMV infection. For people who have weakened immune systems, CMV infection can be serious or even fatal. People who have undergone stem cell or organ transplants seem to be at greatest risk. […] An infant whose mother first became infected with CMV during pregnancy is more likely to experience complications. Complications for the baby can include: Hearing loss, Intellectual disability, Vision problems, Seizures, Lack of coordination, Weakness or problems using muscles.

• #92 Clinical Overview of CMV and Congenital CMV | Cytomegalovirus (CMV) and Congenital CMV Infection | CDC

  https://www.cdc.gov/cytomegalovirus/hcp/clinical-overview/index.html

  Most healthy people, children, and infants who acquire CMV after birth have few symptoms and no long-term health complications from infection. […] Some people who acquire CMV infection may experience a mononucleosis-like condition with prolonged fever and hepatitis. […] Most infants born with CMV infection never have health problems. About 10% of infants with congenital CMV infection will have signs at birth, which include: Petechiae/purpura (blood spots), Jaundice (yellowing of the skin or whites of the eyes), Microcephaly (small head), Intrauterine growth (low birth weight), Hepatosplenomegaly (enlarged liver and spleen), Seizures, Retinitis (damaged eye retina). […] About 40 to 60% of infants born with signs of congenital CMV disease at birth will have long-term health problems. These can be: Hearing loss, Developmental and motor delay, Vision loss, Microcephaly (small head), Lack of coordination or weakness, Seizures. […] Some babies may have hearing loss that may or may not be detected by newborn hearing test.

• #93 Cytomegalovirus (CMV) infection – Symptoms & causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/cmv/symptoms-causes/syc-20355358

  Most babies who have congenital CMV appear healthy at birth. A few babies who have congenital CMV who appear healthy at birth develop signs over time sometimes not for months or years after birth. The most common of these late-occurring signs are hearing loss and developmental delay. A small number of babies may also develop vision problems. […] If your immune system is weakened, you might experience serious problems that affect your: Eyes, Lungs, Liver, Esophagus, Stomach, Intestines, Brain. […] Most people who are infected with CMV who are otherwise healthy experience few if any symptoms. When first infected, some adults may have symptoms similar to infectious mononucleosis, including: Fatigue, Fever, Sore throat, Muscle aches. […] See your doctor if: You have a weakened immune system and you’re experiencing symptoms of CMV infection. For people who have weakened immune systems, CMV infection can be serious or even fatal. People who have undergone stem cell or organ transplants seem to be at greatest risk. […] An infant whose mother first became infected with CMV during pregnancy is more likely to experience complications. Complications for the baby can include: Hearing loss, Intellectual disability, Vision problems, Seizures, Lack of coordination, Weakness or problems using muscles.

• #94 Cytomegalovirus (CMV) during pregnancy | Pregnancy Birth and Baby

  https://www.pregnancybirthbaby.org.au/cytomegalovirus-cmv-during-pregnancy

  If your baby is born with symptoms of congenital CMV, these may include: rash, small head size, enlarged liver and spleen, pneumonia, low platelet count. […] Congenital CMV also increases your baby’s risk of poor growth, miscarriage, stillbirth and death before 3 months of age. […] If your baby is born without symptoms, there’s a chance they could develop health problems later. These may include: poor hearing this is the most common problem, poor vision, intellectual impairment, developmental delay, cerebral palsy, seizures. […] Babies who are born without any obvious symptoms or hearing loss have a lower chance of problems.

• #95 Cytomegalovirus | Boston Children’s Hospital

  https://www.childrenshospital.org/conditions/cytomegalovirus

  Cytomegalovirus (CMV) is a virus related to the herpes virus group of infections. Like herpes, it is inactive at times, but it is an incurable life-time infection. CMV is a major concern if a mother becomes first infected while pregnant. […] Symptoms of a CMV infection may look similar to mononucleosis (fever, swollen glands, constant fatigue, tonsillitis, liver malfunction). […] Most people who have CMV aren’t aware of it because the virus rarely produces symptoms. The biggest concern is for people who have weak immune systems and women who become infected while pregnant. […] About 5 to 10 percent of babies with congenital CMV will have signs of the infection at birth. Of these, over 90 percent will have serious complications including hearing loss, visual impairment, mental retardation, autism, attention deficit/hyperactivity disorder, epilepsy, or sometimes death.

• #96 About Cytomegalovirus | Cytomegalovirus (CMV) and Congenital CMV Infection | CDC

  https://www.cdc.gov/cytomegalovirus/about/index.html

  Healthy people who are infected with CMV usually do not require medical treatment. […] Medications called antivirals are available to treat: CMV infection in people who have weakened immune systems. […] Babies with signs of congenital CMV at birth. […] Valganciclovir is an antiviral that might improve hearing and developmental outcomes in babies. […] Children with congenital CMV should have regular hearing and vision checks.

• #97 Cytomegalovirus (CMV) infection – Symptoms & causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/cmv/symptoms-causes/syc-20355358

  Cytomegalovirus (CMV) is a common virus. Once infected, your body retains the virus for life. Most people don’t know they have cytomegalovirus (CMV) because it rarely causes problems in healthy people. […] If you’re pregnant or if your immune system is weakened, CMV is cause for concern. Women who develop an active CMV infection during pregnancy can pass the virus to their babies, who might then experience symptoms. For people who have weakened immune systems, especially people who have had an organ, stem cell or bone marrow transplant, CMV infection can be fatal. […] Most healthy people who are infected with CMV may experience no symptoms. Some experience minor symptoms. People who are more likely to experience signs and symptoms of CMV include: Newborns who became infected with CMV before they were born (congenital CMV). Infants who become infected during birth or shortly afterward (perinatal CMV). This group includes babies infected through breast milk.

• #98 Cytomegalovirus (CMV) Infection | American Pregnancy Association

  https://americanpregnancy.org/healthy-pregnancy/pregnancy-complications/cytomegalovirus-infection/

  The following potential problems can occur for infants who are infected from their mothers before birth (during pregnancy): Moderate enlargement of the liver and spleen, small red spots on the skin, problems with the eyes and seizures are potential complications. 85-95% will have no symptoms or complications at birth, and the majority will not develop problems later in life. 10-15% of those at birth with no symptoms will go on to develop varying degrees of hearing and mental or coordination problems. […] When cytomegalovirus is transmitted at the time of delivery from contact with genital secretions or later in infancy through breast milk, these infections usually result in few, if any, symptoms or complications. […] Although vaccines for CMV are still in the research and developmental stages, there are some treatment options. One study revealed that hyperimmune globulin, when given to pregnant women with CMV, may help prevent the fetus from contracting the infection. Although there is currently no medication that can fully prevent symptoms and long-term effects of CMV in infants, antiviral medications, including Ganciclovir and Valganciclovir, may be used to treat some aspects of congenital CMV. These medications may even foster brain development and prevent hearing loss.

• #99 Cytomegalovirus | Health | Province of Manitoba

  https://www.gov.mb.ca/health/publichealth/diseases/cmv.html

  Neonatal Infection: Perinatally infected infants do not usually appear to have any disease unless they are premature or immunocompromised. Infection in premature infants can result in swollen liver and various blood disorders. Many may die or become severely ill. […] Infection in immunocompromised people: Symptoms can include fever, muscle pain, general feeling of ill health, joint pain, inflamed and swollen liver, and various blood disorders.

• #100 Cytomegalovirus | Health | Province of Manitoba

  https://www.gov.mb.ca/health/publichealth/diseases/cmv.html

  Neonatal Infection: Perinatally infected infants do not usually appear to have any disease unless they are premature or immunocompromised. Infection in premature infants can result in swollen liver and various blood disorders. Many may die or become severely ill. […] Infection in immunocompromised people: Symptoms can include fever, muscle pain, general feeling of ill health, joint pain, inflamed and swollen liver, and various blood disorders.

• #101 Cytomegalovirus | Health | Province of Manitoba

  https://www.gov.mb.ca/health/publichealth/diseases/cmv.html

  Neonatal Infection: Perinatally infected infants do not usually appear to have any disease unless they are premature or immunocompromised. Infection in premature infants can result in swollen liver and various blood disorders. Many may die or become severely ill. […] Infection in immunocompromised people: Symptoms can include fever, muscle pain, general feeling of ill health, joint pain, inflamed and swollen liver, and various blood disorders.

• #102 Cytomegalovirus (CMV) in Newborns | Cedars-Sinai

  https://www.cedars-sinai.org/health-library/diseases-and-conditions—pediatrics/c/cytomegalovirus-cmv-in-newborns.html

  CMV (cytomegalovirus) is a type of herpes virus. It’s very common. It affects people of all ages and in all parts of the U.S. In most cases, CMV causes mild symptoms, or no symptoms at all. But it can cause serious problems in an unborn baby or newborn. […] Most babies with CMV that is present at birth (congenital CMV) dont have symptoms. If present, symptoms may include: Hearing loss (this may be found during regular newborn hearing screening), Small size, including small head size, Enlarged liver and spleen, Yellow color to skin (jaundice), Small broken blood vessels under the skin, Eye problems. […] Babies with CMV that is passed along during birth or through breastmilk (perinatal CMV) may not have symptoms. Signs and symptoms are usually seen only in very premature or sick newborns between 3 weeks and 6 months of age. They may include: Abnormal blood test results. For example, the results may show low platelet levels, low white blood cell counts, or abnormal liver function, Enlarged liver and spleen, Swelling (inflammation) of the lungs (pneumonitis).

• #103 Cytomegalovirus (CMV) in Newborns | Cedars-Sinai

  https://www.cedars-sinai.org/health-library/diseases-and-conditions—pediatrics/c/cytomegalovirus-cmv-in-newborns.html

  CMV (cytomegalovirus) is a type of herpes virus. It’s very common. It affects people of all ages and in all parts of the U.S. In most cases, CMV causes mild symptoms, or no symptoms at all. But it can cause serious problems in an unborn baby or newborn. […] Most babies with CMV that is present at birth (congenital CMV) dont have symptoms. If present, symptoms may include: Hearing loss (this may be found during regular newborn hearing screening), Small size, including small head size, Enlarged liver and spleen, Yellow color to skin (jaundice), Small broken blood vessels under the skin, Eye problems. […] Babies with CMV that is passed along during birth or through breastmilk (perinatal CMV) may not have symptoms. Signs and symptoms are usually seen only in very premature or sick newborns between 3 weeks and 6 months of age. They may include: Abnormal blood test results. For example, the results may show low platelet levels, low white blood cell counts, or abnormal liver function, Enlarged liver and spleen, Swelling (inflammation) of the lungs (pneumonitis).

• #104 Cytomegalovirus (CMV) Infection | American Pregnancy Association

  https://americanpregnancy.org/healthy-pregnancy/pregnancy-complications/cytomegalovirus-infection/

  The following potential problems can occur for infants who are infected from their mothers before birth (during pregnancy): Moderate enlargement of the liver and spleen, small red spots on the skin, problems with the eyes and seizures are potential complications. 85-95% will have no symptoms or complications at birth, and the majority will not develop problems later in life. 10-15% of those at birth with no symptoms will go on to develop varying degrees of hearing and mental or coordination problems. […] When cytomegalovirus is transmitted at the time of delivery from contact with genital secretions or later in infancy through breast milk, these infections usually result in few, if any, symptoms or complications. […] Although vaccines for CMV are still in the research and developmental stages, there are some treatment options. One study revealed that hyperimmune globulin, when given to pregnant women with CMV, may help prevent the fetus from contracting the infection. Although there is currently no medication that can fully prevent symptoms and long-term effects of CMV in infants, antiviral medications, including Ganciclovir and Valganciclovir, may be used to treat some aspects of congenital CMV. These medications may even foster brain development and prevent hearing loss.

• #105 Cytomegalovirus (CMV) | Better Health Channel

  https://www.betterhealth.vic.gov.au/health/conditionsandtreatments/cytomegalovirus-cmv

  Once a person has contracted CMV, they will carry it for life. This is because the virus lies dormant inside the body and may or may not reactivate itself at any time. […] Women can catch CMV during pregnancy and pass it on to their baby this is called congenital CMV. Around one in ten infected babies will have lasting problems. These can include deafness, poor eyesight, intellectual disability, an enlarged liver or spleen, and a small head. […] People with compromised immune systems, such as people receiving organ transplants, and people receiving treatment for HIV/AIDS or cancer are at increased risk of serious complications of CMV. […] Treatment depends on the severity of the condition. In a healthy person, bed rest, drinking plenty of fluids and medical supervision are all that is generally required. Pregnant women and patients with suppressed immunity need careful medical monitoring and frequent testing, including blood, sputum and urine tests. Antiviral medication may be prescribed.

• #106 Cytomegalovirus (CMV) (for Parents) | Nemours KidsHealth

  https://kidshealth.org/en/parents/cytomegalovirus.html

  For example, a serious CMV infection before birth may cause lifelong developmental problems. But cytomegalovirus infection in teens may last only 2 to 3 weeks and cause no lasting problems. […] After a person has the infection, the virus stays in the body, lying dormant (not active). It can become „reactivated” (come back) weeks or years later. In people with very weak immune systems (such as people who have AIDS or who get chemotherapy), the reactivated virus may cause serious illness. Most people, though, will not get symptoms of CMV again.

• #107 Cytomegalovirus (CMV) in Pregnancy | ACOG

  https://www.acog.org/clinical-information/physician-faqs/cytomegalovirus-in-pregnancy

  Cytomegalovirus (CMV) is a ubiquitous double-stranded DNA herpesvirus that is transmitted by sexual contact or direct contact with infected blood, urine, or saliva. After an incubation period of 28-60 days (mean, 40 days), CMV infection induces immunoglobulin M (IgM) antibody production followed by an IgG antibody response. Viremia can be detected for 2-3 weeks after primary infection (infection in a previously seronegative individual). After the primary infection, CMV remains latent in host cells and recurrent, or secondary, infection can occur. […] Although adults with primary CMV infection are usually asymptomatic, individuals may experience a mononucleosis-like syndrome, with fever, chills, myalgias, malaise, leukocytosis, lymphocytosis, abnormal liver function, and lymphadenopathy. […] Congenital CMV may be suspected prenatally after a documented maternal primary infection or, more commonly, because universal screening is not recommended, after ultrasound findings suggestive of infection. These findings include abdominal and liver calcifications, hepatosplenomegaly, echogenic bowel or kidneys, ascites, cerebral ventriculomegaly, intracranial calcifications, microcephaly, hydrops fetalis, and growth restriction.

• #108 Cytomegalovirus (CMV) in Pregnancy | ACOG

  https://www.acog.org/clinical-information/physician-faqs/cytomegalovirus-in-pregnancy

  Cytomegalovirus (CMV) is a ubiquitous double-stranded DNA herpesvirus that is transmitted by sexual contact or direct contact with infected blood, urine, or saliva. After an incubation period of 28-60 days (mean, 40 days), CMV infection induces immunoglobulin M (IgM) antibody production followed by an IgG antibody response. Viremia can be detected for 2-3 weeks after primary infection (infection in a previously seronegative individual). After the primary infection, CMV remains latent in host cells and recurrent, or secondary, infection can occur. […] Although adults with primary CMV infection are usually asymptomatic, individuals may experience a mononucleosis-like syndrome, with fever, chills, myalgias, malaise, leukocytosis, lymphocytosis, abnormal liver function, and lymphadenopathy. […] Congenital CMV may be suspected prenatally after a documented maternal primary infection or, more commonly, because universal screening is not recommended, after ultrasound findings suggestive of infection. These findings include abdominal and liver calcifications, hepatosplenomegaly, echogenic bowel or kidneys, ascites, cerebral ventriculomegaly, intracranial calcifications, microcephaly, hydrops fetalis, and growth restriction.

• #109 Cytomegalovirus (CMV) | Better Health Channel

  https://www.betterhealth.vic.gov.au/health/conditionsandtreatments/cytomegalovirus-cmv

  Cytomegalovirus (CMV) is a member of the herpes family. In healthy people, it causes a mild flu-like illness that lasts a few days or weeks. In susceptible people, such as those with suppressed immunity or unborn babies, CMV can be a dangerous infection. […] In healthy people, CMV infection causes nothing more than a flu-like illness that lasts a few days. In certain people, however, including transplant patients and pregnant women, the effects can be much more serious. […] Symptoms may vary depending on which organ is affected, but generally a person with CMV will experience lethargy, a high temperature and a drop in white blood cell levels. […] For most people, a CMV infection poses no real health threat. The symptoms are generally mild and flu-like, although some may feel unwell for a few weeks, rather than a few days. Some people experience no symptoms.

• #110 Cytomegalovirus (CMV) Infection: Symptoms, Treatment, Pregnancy

  https://www.medicinenet.com/cytomegalovirus_cmv/article.htm

  CMV rarely causes complications in healthy people. The risk of complications is higher in individuals with weakened immune systems. CMV can infect the stomach and intestines, causing fever, abdominal pain, blood in the stool, and inflammation of the colon (colitis). Inflammation can also occur in the liver (hepatitis), lung (pneumonitis), and brain (encephalitis). Infection in the eye (retinitis) can cause blindness. Newborns with congenital CMV infection can develop hearing and vision loss, mental disability, and seizures. […] Most healthy children and adults who develop symptoms will recover without any complications. Fatigue may last for several months after the asymptomatic infection is over. Prognosis depends on how severe the CMV infection is and the person’s underlying immune system. Giving antiviral medication to people who have a very weak immune system, such as bone marrow transplant recipients, improves prognosis.

• #111 Cytomegalovirus (CMV) | Causes, Symptoms, and Treatment

  https://patient.info/doctor/cytomegalovirus

  Cytomegalovirus (CMV) is a member of the herpesvirus family. Infection is worldwide and usually asymptomatic. CMV may cause a mononucleosis infection in healthy individuals but can cause severe illness in congenital infection and in an immunocompromised host. […] The most common disease manifestation is gastrointestinal disease. CMV pneumonia is the most serious complication but has become less common with prevention strategies for at-risk patients. Rare manifestations include retinitis and encephalitis. CMV also has an immunosuppressive effect, which can lead to an increased susceptibility to invasive bacterial and fungal disease as well as graft-versus-host disease (GvHD). […] After initial infection, human CMV remains in a persistent state within the host. Immunity against the virus controls replication, although intermittent viral shedding can still take place in the immunocompetent person.

• #112 Cytomegalovirus (CMV) | Causes, Symptoms, and Treatment

  https://patient.info/doctor/cytomegalovirus

  Cytomegalovirus (CMV) is a member of the herpesvirus family. Infection is worldwide and usually asymptomatic. CMV may cause a mononucleosis infection in healthy individuals but can cause severe illness in congenital infection and in an immunocompromised host. […] The most common disease manifestation is gastrointestinal disease. CMV pneumonia is the most serious complication but has become less common with prevention strategies for at-risk patients. Rare manifestations include retinitis and encephalitis. CMV also has an immunosuppressive effect, which can lead to an increased susceptibility to invasive bacterial and fungal disease as well as graft-versus-host disease (GvHD). […] After initial infection, human CMV remains in a persistent state within the host. Immunity against the virus controls replication, although intermittent viral shedding can still take place in the immunocompetent person.

• #113 Cytomegalovirus infection – Symptoms, diagnosis and treatment | BMJ Best Practice

  https://bestpractice.bmj.com/topics/en-gb/560

  Cytomegalovirus (CMV) infection often presents asymptomatically or as an infectious mononucleosis-like syndrome (fever, lymphadenopathy, and atypical lymphocytosis) in people with normal immune systems. […] In immunocompromised people (patients with AIDS and transplant recipients), the disease manifests with fever, bone marrow suppression, and tissue-invasive conditions such as pneumonitis, hepatitis, colitis, nephritis, and retinitis. […] In fetuses, CMV infection can lead to cytomegalic inclusion disease, characterised by severe neurological abnormalities, intellectual disability, and hearing defects. […] When reactivation (or primary infection) occurs in patients with severely compromised immune function (such as transplant recipients or patients with AIDS and a CD4 count 50 cells/microlitre), uncontrolled CMV replication often ensues, which leads to the clinical manifestations characterised by fever, bone marrow suppression, and tissue-invasive disease. […] Key diagnostic factors include malaise, fever, diarrhoea, nausea and vomiting, visual floaters and blindness, and abnormalities on fundoscopy. […] In newborns, CMV infection can present with microcephaly, poor tone and motor function, abnormal head lag, and hearing loss.

• #114 Cytomegalovirus (CMV): Symptoms, Causes, Treatment

  https://www.webmd.com/hiv-aids/aids-hiv-opportunistic-infections-cytomegalovirus

  In severe cases, CMV can lead to a miscarriage. […] Its rare, but CMV can cause complications including: Mononucleosis, Guillain-Barr syndrome, Brain inflammation (encephalitis), Heart inflammation (myocarditis). […] In people with HIV, complications include: Retinitis, Pneumonia, Skin rashes and lesions, Problems in the nerves, esophagus, lungs, colon, or mucous membranes, Brain swelling. […] Congenital CMV can have lifelong effects. The risks are highest if you have your first CMV infection while you are pregnant. […] If you have a weakened immune system, you might need treatment for the rest of your life to prevent complications.

• #115 Cytomegalovirus (CMV) Infection: Causes & Symptoms

  https://my.clevelandclinic.org/health/diseases/21166-cytomegalovirus

  If you have a weakened immune system, how a CMV infection will affect you depends on how soon its treated and where the infection is in your body. Youll probably need to be hospitalized for treatment. Early treatment of a CMV infection gives you the best chance of a full recovery. […] People with weakened immune systems, especially those whove received a stem cell transplant, are most likely to experience serious or life-threatening complications of cytomegalovirus. Complications include: […] Lasting cognitive issues, including trouble focusing, remembering and problem-solving. […] Partial or complete loss of vision. […] A tear (perforation) in your esophagus or intestines. […] Pneumonia, possibly leading to respiratory failure. […] Rejection of donor organ.

• #116 Cytomegalovirus (CMV): Practice Essentials, Background, Pathophysiology

  https://emedicine.medscape.com/article/215702-overview

  Rarer manifestations of CMV infections in immunocompetent individuals include Guillain-Barr syndrome, meningoencephalitis, pericarditis, myocarditis, thrombocytopenia, and hemolytic anemia. […] CMV is an opportunistic infection in patients with advanced HIV/AIDS and can effect multiorgan systems. […] The most common sites of CMV related gastrointestinal infection are the esophagus and the colon. […] Symptoms include dry cough, shortness of breath, and fever. […] CMV hepatitis is defined as elevated bilirubin and/or liver enzymes levels in combination with the detection of CMV in the absence of other causes for hepatitis. […] Hepatitis has been commonly observed in patients with primary CMV infection and mononucleosis. […] The prognosis of CMV hepatitis generally is good. Most patients recover completely. Symptoms can persist, usually in the form of fatigue, for several months after primary infection.

• #117 Cytomegalovirus (CMV) | Causes, Symptoms, and Treatment

  https://patient.info/doctor/cytomegalovirus

  Cytomegalovirus (CMV) is a member of the herpesvirus family. Infection is worldwide and usually asymptomatic. CMV may cause a mononucleosis infection in healthy individuals but can cause severe illness in congenital infection and in an immunocompromised host. […] The most common disease manifestation is gastrointestinal disease. CMV pneumonia is the most serious complication but has become less common with prevention strategies for at-risk patients. Rare manifestations include retinitis and encephalitis. CMV also has an immunosuppressive effect, which can lead to an increased susceptibility to invasive bacterial and fungal disease as well as graft-versus-host disease (GvHD). […] After initial infection, human CMV remains in a persistent state within the host. Immunity against the virus controls replication, although intermittent viral shedding can still take place in the immunocompetent person.

• #118 Cytomegalovirus (CMV) Infection in Newborns – Children’s Health Issues – Merck Manual Consumer Version

  https://www.merckmanuals.com/home/children-s-health-issues/infections-in-newborns/cytomegalovirus-cmv-infection-in-newborns

  Some newborns have all of these symptoms. […] CMV infection is fatal in 5 to 10% of newborns who have symptoms. Most of the infants who have symptoms who survive develop hearing loss. […] About 5 to 15% of newborns who do not have symptoms eventually develop neurologic problems (most commonly hearing loss). Some degree of hearing loss is the most common.

• #119 Cytomegalovirus (CMV) Infection in Newborns – Children’s Health Issues – Merck Manual Consumer Version

  https://www.merckmanuals.com/home/children-s-health-issues/infections-in-newborns/cytomegalovirus-cmv-infection-in-newborns

  Some newborns have all of these symptoms. […] CMV infection is fatal in 5 to 10% of newborns who have symptoms. Most of the infants who have symptoms who survive develop hearing loss. […] About 5 to 15% of newborns who do not have symptoms eventually develop neurologic problems (most commonly hearing loss). Some degree of hearing loss is the most common.

• #120 Congenital cytomegalovirus infection – Wikipedia

  https://en.wikipedia.org/wiki/Congenital_cytomegalovirus_infection

  Another 5% to 10% of infants who are infected but without symptoms at birth will subsequently have varying degrees of hearing and mental or coordination problems. CMV is the most common cause of non-genetic sensorineural hearing loss in children. The onset of hearing loss can occur at any point during childhood, although commonly within the first decade. It is progressive and can affect both ears. […] Symptoms associated with CMV, such as hearing loss, can result in further developmental delay. A delay in general speech and language development is more common in children with CMV. Children with symptomatic CMV have been found to have a greater incidence of long-term neurological and neurodevelopmental complications than children with fetal alcohol syndrome or down syndrome. […] Congenital cytomegalovirus infection can be an important cause of intraventricular hemorrhage and neonatal encephalopathy.

• #121 Congenital cytomegalovirus infection – Wikipedia

  https://en.wikipedia.org/wiki/Congenital_cytomegalovirus_infection

  Another 5% to 10% of infants who are infected but without symptoms at birth will subsequently have varying degrees of hearing and mental or coordination problems. CMV is the most common cause of non-genetic sensorineural hearing loss in children. The onset of hearing loss can occur at any point during childhood, although commonly within the first decade. It is progressive and can affect both ears. […] Symptoms associated with CMV, such as hearing loss, can result in further developmental delay. A delay in general speech and language development is more common in children with CMV. Children with symptomatic CMV have been found to have a greater incidence of long-term neurological and neurodevelopmental complications than children with fetal alcohol syndrome or down syndrome. […] Congenital cytomegalovirus infection can be an important cause of intraventricular hemorrhage and neonatal encephalopathy.

• #122 Cytomegalovirus (CMV) in Pregnancy: Symptoms, Causes & Treatment

  https://www.whattoexpect.com/pregnancy/pregnancy-health/complications/cytomegalovirus.aspx

  About 1 in 200 babies is born with congenital CMV (or a CMV infection at birth). Of the approximately 1 to 4% of people who get CMV during pregnancy, about 1 in 3 pass the infection on to their babies. […] Even if you do pass CMV on to your baby during pregnancy, most babies born with the virus don’t have health problems. In all, about 1 in 5 babies with congenital CMV have birth defects or other long-term problems. Research suggests about 80 to 90% of babies with congenital CMV are asymptomatic at birth and have very low chances of long-term complications. The odds of long-term complications increase significantly in babies who are infected early on in pregnancy and in newborns who experience symptoms at birth. […] Although CMV often comes and goes without any obvious symptoms, you may experience the following signs of CMV: Fever that lasts a few days, Constant, persistent fatigue, Swollen glands, Sore throat. […] Rarely, CMV can lead to mononucleosis (a condition caused by certain viruses that causes extreme fatigue among other symptoms).

• #123 Cytomegalovirus (CMV) in Pregnancy: Symptoms, Causes & Treatment

  https://www.whattoexpect.com/pregnancy/pregnancy-health/complications/cytomegalovirus.aspx

  About 1 in 200 babies is born with congenital CMV (or a CMV infection at birth). Of the approximately 1 to 4% of people who get CMV during pregnancy, about 1 in 3 pass the infection on to their babies. […] Even if you do pass CMV on to your baby during pregnancy, most babies born with the virus don’t have health problems. In all, about 1 in 5 babies with congenital CMV have birth defects or other long-term problems. Research suggests about 80 to 90% of babies with congenital CMV are asymptomatic at birth and have very low chances of long-term complications. The odds of long-term complications increase significantly in babies who are infected early on in pregnancy and in newborns who experience symptoms at birth. […] Although CMV often comes and goes without any obvious symptoms, you may experience the following signs of CMV: Fever that lasts a few days, Constant, persistent fatigue, Swollen glands, Sore throat. […] Rarely, CMV can lead to mononucleosis (a condition caused by certain viruses that causes extreme fatigue among other symptoms).

• #124 Cytomegalovirus (CMV) Infection: Causes & Symptoms

  https://my.clevelandclinic.org/health/diseases/21166-cytomegalovirus

  If you have a weakened immune system, how a CMV infection will affect you depends on how soon its treated and where the infection is in your body. Youll probably need to be hospitalized for treatment. Early treatment of a CMV infection gives you the best chance of a full recovery. […] People with weakened immune systems, especially those whove received a stem cell transplant, are most likely to experience serious or life-threatening complications of cytomegalovirus. Complications include: […] Lasting cognitive issues, including trouble focusing, remembering and problem-solving. […] Partial or complete loss of vision. […] A tear (perforation) in your esophagus or intestines. […] Pneumonia, possibly leading to respiratory failure. […] Rejection of donor organ.

• #125 Cytomegalovirus – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK459185/

  The prognosis for most patients with CMV is good as long as they do not have a state of immunosuppression. Recovery is usually complete with treatment. However, fatigue may persist for several months. […] CMV pneumonia in marrow transplant patients can carry high mortality if the treatment is delayed. […] Relapse of CMV is very common in transplant patients. […] In the non-immunocompromised patient, CMV is rarely associated with mortality. However, in patients who are immunocompromised, receiving chemotherapy, or are using corticosteroids, CMV can have significant morbidity and mortality. After bone marrow transplants, mortality rates of 10-75% have been reported. […] Overall, patients with comorbidity and immunosuppression have poor prognosis. Patients who develop CMV pneumonitis and require ventilation have an abysmal prognosis.

• #126 Cytomegalovirus – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK459185/

  The prognosis for most patients with CMV is good as long as they do not have a state of immunosuppression. Recovery is usually complete with treatment. However, fatigue may persist for several months. […] CMV pneumonia in marrow transplant patients can carry high mortality if the treatment is delayed. […] Relapse of CMV is very common in transplant patients. […] In the non-immunocompromised patient, CMV is rarely associated with mortality. However, in patients who are immunocompromised, receiving chemotherapy, or are using corticosteroids, CMV can have significant morbidity and mortality. After bone marrow transplants, mortality rates of 10-75% have been reported. […] Overall, patients with comorbidity and immunosuppression have poor prognosis. Patients who develop CMV pneumonitis and require ventilation have an abysmal prognosis.

• #127 Cytomegalovirus – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK459185/

  The prognosis for most patients with CMV is good as long as they do not have a state of immunosuppression. Recovery is usually complete with treatment. However, fatigue may persist for several months. […] CMV pneumonia in marrow transplant patients can carry high mortality if the treatment is delayed. […] Relapse of CMV is very common in transplant patients. […] In the non-immunocompromised patient, CMV is rarely associated with mortality. However, in patients who are immunocompromised, receiving chemotherapy, or are using corticosteroids, CMV can have significant morbidity and mortality. After bone marrow transplants, mortality rates of 10-75% have been reported. […] Overall, patients with comorbidity and immunosuppression have poor prognosis. Patients who develop CMV pneumonitis and require ventilation have an abysmal prognosis.

• #128 Cytomegalovirus – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK459185/

  The prognosis for most patients with CMV is good as long as they do not have a state of immunosuppression. Recovery is usually complete with treatment. However, fatigue may persist for several months. […] CMV pneumonia in marrow transplant patients can carry high mortality if the treatment is delayed. […] Relapse of CMV is very common in transplant patients. […] In the non-immunocompromised patient, CMV is rarely associated with mortality. However, in patients who are immunocompromised, receiving chemotherapy, or are using corticosteroids, CMV can have significant morbidity and mortality. After bone marrow transplants, mortality rates of 10-75% have been reported. […] Overall, patients with comorbidity and immunosuppression have poor prognosis. Patients who develop CMV pneumonitis and require ventilation have an abysmal prognosis.

• #129 Cytomegalovirus – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK459185/

  The prognosis for most patients with CMV is good as long as they do not have a state of immunosuppression. Recovery is usually complete with treatment. However, fatigue may persist for several months. […] CMV pneumonia in marrow transplant patients can carry high mortality if the treatment is delayed. […] Relapse of CMV is very common in transplant patients. […] In the non-immunocompromised patient, CMV is rarely associated with mortality. However, in patients who are immunocompromised, receiving chemotherapy, or are using corticosteroids, CMV can have significant morbidity and mortality. After bone marrow transplants, mortality rates of 10-75% have been reported. […] Overall, patients with comorbidity and immunosuppression have poor prognosis. Patients who develop CMV pneumonitis and require ventilation have an abysmal prognosis.

• #130 Cytomegalovirus – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK459185/

  The prognosis for most patients with CMV is good as long as they do not have a state of immunosuppression. Recovery is usually complete with treatment. However, fatigue may persist for several months. […] CMV pneumonia in marrow transplant patients can carry high mortality if the treatment is delayed. […] Relapse of CMV is very common in transplant patients. […] In the non-immunocompromised patient, CMV is rarely associated with mortality. However, in patients who are immunocompromised, receiving chemotherapy, or are using corticosteroids, CMV can have significant morbidity and mortality. After bone marrow transplants, mortality rates of 10-75% have been reported. […] Overall, patients with comorbidity and immunosuppression have poor prognosis. Patients who develop CMV pneumonitis and require ventilation have an abysmal prognosis.

• #131 Cytomegalovirus (CMV) Infection: Causes & Symptoms

  https://my.clevelandclinic.org/health/diseases/21166-cytomegalovirus

  If you have a weakened immune system, how a CMV infection will affect you depends on how soon its treated and where the infection is in your body. Youll probably need to be hospitalized for treatment. Early treatment of a CMV infection gives you the best chance of a full recovery. […] People with weakened immune systems, especially those whove received a stem cell transplant, are most likely to experience serious or life-threatening complications of cytomegalovirus. Complications include: […] Lasting cognitive issues, including trouble focusing, remembering and problem-solving. […] Partial or complete loss of vision. […] A tear (perforation) in your esophagus or intestines. […] Pneumonia, possibly leading to respiratory failure. […] Rejection of donor organ.

• #132 Cytomegalovirus (CMV) Infection: Causes & Symptoms

  https://my.clevelandclinic.org/health/diseases/21166-cytomegalovirus

  Low birth weight or poor weight gain. […] Anemia. […] Yellowish skin and eyes (jaundice). […] Red spots of blood under the skin that look like a rash (purpura or petechiae). […] Enlarged liver (hepatomegaly). […] Enlarged spleen (splenomegaly). […] Small head size (microcephaly). […] Seizures. […] Hearing loss. […] Delays or differences in motor skill development. […] The outlook for CMV varies depending on whether you or your child were born with CMV and whether you have a weakened immune system. […] People with healthy immune systems who develop symptoms of CMV can be sick for one week to several months. Serious complications from CMV are rare. […] About 50% of children who have symptoms of CMV at birth will have lasting health effects. These often include hearing or vision loss and developmental differences. Hearing loss can develop later even if your child didnt have symptoms of CMV at birth. Infants with severe symptoms may have life-threatening complications of CMV.

• #133 Cytomegalovirus (CMV) Infection: Causes & Symptoms

  https://my.clevelandclinic.org/health/diseases/21166-cytomegalovirus

  Low birth weight or poor weight gain. […] Anemia. […] Yellowish skin and eyes (jaundice). […] Red spots of blood under the skin that look like a rash (purpura or petechiae). […] Enlarged liver (hepatomegaly). […] Enlarged spleen (splenomegaly). […] Small head size (microcephaly). […] Seizures. […] Hearing loss. […] Delays or differences in motor skill development. […] The outlook for CMV varies depending on whether you or your child were born with CMV and whether you have a weakened immune system. […] People with healthy immune systems who develop symptoms of CMV can be sick for one week to several months. Serious complications from CMV are rare. […] About 50% of children who have symptoms of CMV at birth will have lasting health effects. These often include hearing or vision loss and developmental differences. Hearing loss can develop later even if your child didnt have symptoms of CMV at birth. Infants with severe symptoms may have life-threatening complications of CMV.

• #134 Cytomegalovirus (CMV) | Healthify

  https://healthify.nz/health-a-z/c/cytomegalovirus-cmv

  Most people infected with CMV show no signs or symptoms. Thats because a healthy persons immune system usually keeps the virus from causing illness. […] Some people get symptoms similar to the flu or glandular fever the first time they catch CMV, including: a high temperature of 38C or more, aching muscles, tiredness, feeling sick, sore throat, swollen glands. […] If you do have symptoms, they normally get better on their own within about 3 weeks. Its rare to get symptoms again unless your immune system becomes weakened, eg, due to organ transplant or chemotherapy. It can also be reactivated during pregnancy. […] If you have a weakened immune system and get CMV, you can have more serious symptoms affecting your eyes, lungs, liver, oesophagus, stomach and intestines. […] A small number of babies with congenital CMV are sick at birth and have significant signs and symptoms. These include: premature birth, low birth weight, yellow skin and eyes (jaundice), enlarged and poorly functioning liver, purple skin splotches or a rash or both, abnormally small head (microencephaly), enlarged spleen, pneumonia, seizures. […] In the most severe cases, congenital CMV can lead to stillbirth (your baby born dead) or neonatal death (dying after birth). […] Some babies with signs of congenital CMV infection at birth may have long-term health problems, eg, hearing loss, developmental and motor delay, and vision loss.

• #135 Cytomegalovirus (CMV) Infection: Causes & Symptoms

  https://my.clevelandclinic.org/health/diseases/21166-cytomegalovirus

  Low birth weight or poor weight gain. […] Anemia. […] Yellowish skin and eyes (jaundice). […] Red spots of blood under the skin that look like a rash (purpura or petechiae). […] Enlarged liver (hepatomegaly). […] Enlarged spleen (splenomegaly). […] Small head size (microcephaly). […] Seizures. […] Hearing loss. […] Delays or differences in motor skill development. […] The outlook for CMV varies depending on whether you or your child were born with CMV and whether you have a weakened immune system. […] People with healthy immune systems who develop symptoms of CMV can be sick for one week to several months. Serious complications from CMV are rare. […] About 50% of children who have symptoms of CMV at birth will have lasting health effects. These often include hearing or vision loss and developmental differences. Hearing loss can develop later even if your child didnt have symptoms of CMV at birth. Infants with severe symptoms may have life-threatening complications of CMV.

• #136 About Cytomegalovirus | Cytomegalovirus (CMV) and Congenital CMV Infection | CDC

  https://www.cdc.gov/cytomegalovirus/about/index.html

  Healthy people who are infected with CMV usually do not require medical treatment. […] Medications called antivirals are available to treat: CMV infection in people who have weakened immune systems. […] Babies with signs of congenital CMV at birth. […] Valganciclovir is an antiviral that might improve hearing and developmental outcomes in babies. […] Children with congenital CMV should have regular hearing and vision checks.

• #137 Congenital and Perinatal Cytomegalovirus Infection (CMV) – Pediatrics – MSD Manual Professional Edition

  https://www.msdmanuals.com/professional/pediatrics/infections-in-neonates/congenital-and-perinatal-cytomegalovirus-infection-cmv

  Symptomatic neonates have a mortality rate of up to 5 to 10%. Approximately 30 to 65% of survivors of symptomatic congenital CMV develop sensorineural hearing loss. […] Among asymptomatic neonates, 5 to 15% eventually develop neurologic sequelae; hearing loss is the most common. […] Parenteral ganciclovir or oral valganciclovir may prevent hearing deterioration and improve neurodevelopmental outcomes in infants with symptomatic infection.

• #138 Cytomegalovirus – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK459185/

  Cytomegalovirus (CMV) is a wide-spread virus, with manifestations ranging from asymptomatic to severe end-organ dysfunction in immunocompromised patients with congenital CMV disease. […] CMV infection may be asymptomatic in healthy people, but it can be life-threatening in an immunocompromised patient. Congenital cytomegalovirus infection can cause morbidity and even death. After infection, CMV often remains latent, but it can reactivate at any time. Eventually, it causes mucoepidermoid carcinoma, and it may be responsible for prostate cancer. […] Primary CMV infection usually has an asymptomatic or subclinical course. Mononucleosis is the most prevalent presentation of CMV in patients with an intact immune system, characterized by fever, rash, and leukocytosis. […] In patients with a depressed immune system, CMV is more aggressive. Specific disease entities include: CMV hepatitis which may lead to fulminant liver failure, Cytomegalovirus retinitis characterized by a „pizza pie appearance” on ophthalmic exam, CMV esophagitis, Cytomegalovirus colitis, CMV pneumonitis, Polyradiculopathy, Transverse myelitis, Subacute encephalitis.

• #139 Cytomegalovirus infection – Symptoms, diagnosis and treatment | BMJ Best Practice

  https://bestpractice.bmj.com/topics/en-gb/560

  Cytomegalovirus (CMV) infection often presents asymptomatically or as an infectious mononucleosis-like syndrome (fever, lymphadenopathy, and atypical lymphocytosis) in people with normal immune systems. […] In immunocompromised people (patients with AIDS and transplant recipients), the disease manifests with fever, bone marrow suppression, and tissue-invasive conditions such as pneumonitis, hepatitis, colitis, nephritis, and retinitis. […] In fetuses, CMV infection can lead to cytomegalic inclusion disease, characterised by severe neurological abnormalities, intellectual disability, and hearing defects. […] When reactivation (or primary infection) occurs in patients with severely compromised immune function (such as transplant recipients or patients with AIDS and a CD4 count 50 cells/microlitre), uncontrolled CMV replication often ensues, which leads to the clinical manifestations characterised by fever, bone marrow suppression, and tissue-invasive disease. […] Key diagnostic factors include malaise, fever, diarrhoea, nausea and vomiting, visual floaters and blindness, and abnormalities on fundoscopy. […] In newborns, CMV infection can present with microcephaly, poor tone and motor function, abnormal head lag, and hearing loss.

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