Materiały źródłowe

• #1 How Can Hemochromatosis Be Prevented? | Hematology-Oncology Associates of CNY

  https://www.hoacny.com/patient-resources/blood-disorders/what-hemochromatosis/how-can-hemochromatosis-be-prevented

  You can’t prevent primary, or inherited, hemochromatosis. However, not everyone who inherits hemochromatosis genes develops symptoms or complications of the disease. […] People who have hemochromatosis (or a family history of it) and are planning to have children may want to consider genetic testing and counseling. Testing will help show whether one or both parents have faulty HFE genes. A genetic counselor also can help figure out the likelihood of the parents passing the faulty genes on to their children.

• #1 Patient education: Hereditary hemochromatosis (Beyond the Basics) – UpToDate

  https://www.uptodate.com/contents/hereditary-hemochromatosis-beyond-the-basics

  Early identification and treatment of hemochromatosis can prevent complications and ensure a normal life expectancy. Treatment typically involves regular phlebotomy (removal of blood) since red blood cells contain a large amount of the body’s iron. […] Treatment of hemochromatosis requires removal of excessive iron from the body, usually by periodically removing blood (referred to as „therapeutic phlebotomy”). […] Phlebotomy can effectively remove iron and resolve some, but not all, complications of hemochromatosis. If complications have not yet occurred, phlebotomy is very effective in preventing them, as long as sufficient iron is removed from the body. Most people will have a normal life expectancy. […] People who are receiving treatment for hemochromatosis do not have to follow a special diet. There is no evidence that the condition is worsened by consuming moderate amounts of iron-rich foods such as red meat and liver. […] However, people with hemochromatosis should avoid iron supplements (including multivitamins plus iron). […] Phlebotomy is appropriate and beneficial for most people with excess iron stores from hemochromatosis, including older adults and people who have no symptoms.

• #1 Hemochromatosis – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/hemochromatosis/diagnosis-treatment/drc-20351448

  Genetic testing is recommended for all parents, siblings and children of anyone diagnosed with hemochromatosis. If a gene change is found in only one parent, then children do not need to be tested. […] In addition to therapeutic blood removal, making some lifestyle changes may further reduce the risk of complications from hemochromatosis, such as: […] Don’t take iron supplements and multivitamins containing iron. These can increase iron levels even more. […] Don’t take vitamin C supplements. Vitamin C increases absorption of iron. There’s usually no need to restrict vitamin C in your diet, however. […] Stay away from alcohol. Alcohol greatly increases the risk of liver damage in people with hemochromatosis. If you have hemochromatosis and you already have liver disease, avoid alcohol completely.

• #1 About Hereditary Hemochromatosis | Hereditary Hemochromatosis | CDC

  https://www.cdc.gov/hereditary-hemochromatosis/about/index.html

  Early diagnosis and treatment are critical to prevent complications from the disease. […] If you have a family member, especially a sibling, who is known to have hereditary hemochromatosis, talk to your healthcare provider about genetic testing. […] If you are diagnosed with hemochromatosis, regularly scheduled blood removal is the most effective way to lower the amount of iron in your body. […] Your healthcare provider may also recommend annual blood tests to check your iron levels. […] Dietary changes, such as avoiding multivitamins, vitamin C supplements, and iron supplements, which can increase iron throughout your body. […] No alcohol use (because alcohol increases the risk of liver damage). […] Steps to prevent infections, including not eating uncooked fish and shellfish and getting recommended vaccinations, including those against hepatitis A and B.

• #1 Hereditary Hemochromatosis: Rapid Evidence Review | AAFP

  https://www.aafp.org/pubs/afp/issues/2021/0900/p263.html

  Genetic testing for the C282Y and H63D mutations of the HFE gene is recommended for first-degree relatives of people with hereditary hemochromatosis; screening does not need to begin until 18 years of age because clinical manifestations are rare before this age. […] Population-level genetic testing or laboratory screening for hereditary hemochromatosis is not recommended because of the cost and the variable prevalence and incomplete penetrance of the C282Y mutation. […] Aside from alcohol cessation, dietary modifications have minimal impact on iron overload and are generally not recommended in patients with hereditary hemochromatosis. […] Lifelong phlebotomy is the mainstay of treatment to maintain a goal serum ferritin level of around 50 ng per mL (50 mcg per L). […] Phlebotomy should be offered to patients with elevated serum ferritin levels (greater than 300 ng per mL in men and greater than 200 ng per mL in women) or a transferrin saturation of greater than 45% in both men and women.

• #1 Treatment of Hemochromatosis – NIDDK

  https://www.niddk.nih.gov/health-information/liver-disease/hemochromatosis/treatment

  Phlebotomy can prevent the complications of hemochromatosis. […] You can’t prevent inheriting the gene mutations that cause primary hemochromatosis. However, early diagnosis is important since early treatment with phlebotomy can prevent complications of iron overload caused by these gene mutations. […] Secondary hemochromatosis due to blood transfusion cannot be prevented easily. However, doctors can check iron levels and start treatment with chelating agents early, before iron overload causes damage to the liver, joints, and other organs. […] If doctors know a pregnant woman is at risk for having an infant with neonatal hemochromatosis due to a family history of the condition, doctors can treat the pregnant woman with IV immunoglobulin to lower the chance that the newborn will have severe iron overload.

• #1 Patient education: Hereditary hemochromatosis (Beyond the Basics) – UpToDate

  https://www.uptodate.com/contents/hereditary-hemochromatosis-beyond-the-basics/print

  Phlebotomy can help prevent the potentially life-threatening complications of cirrhosis and liver cancer. […] Phlebotomy is most likely to reverse liver disease in an early stage, but phlebotomy can still improve liver function in people who have developed cirrhosis. […] Phlebotomy may resolve joint pain and heart disease. […] The primary goal of screening is to detect hemochromatosis before there are symptoms or complications. […] Early testing and treatment can help to prevent complications.

• #1 Hemochromatosis – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/hemochromatosis/diagnosis-treatment/drc-20351448

  Don’t eat raw fish and shellfish. People with hemochromatosis are at risk of infections, particularly those caused by certain bacteria in raw fish and shellfish. […] Treating hemochromatosis can help relieve symptoms of tiredness, stomach pain and skin darkening. It can help prevent serious complications such as liver disease, heart disease and diabetes. If you already have one of these conditions, phlebotomy may slow the progression of the disease. In some cases, it may even reverse it.

• #1

  https://bpac.org.nz/bt/2015/april/haemochromatosis.aspx

  Following a diagnosis, the most important clinical steps are to investigate patients for the presence of haemochromatosis complications and initiate treatment. Patients should be assessed for the presence of complications arising from iron overload and treated, such as diabetes mellitus, joint disease, endocrine disturbances (hypothyroidism and hypogonadism), cardiac disease, porphyria cutanea tarda and osteoporosis. The key clinical intervention for treating haemochromatosis is venesection (phlebotomy) to reduce iron stores. Clinical guidelines recommend that all patients with haemochromatosis are offered venesection to normalise ferritin levels. […] However, as there is no reliable method of predicting which patients will develop complications, and venesection is a low-risk procedure, clinical guidelines recommend offering venesection to all patients with elevated ferritin levels.

• #1

  https://www.nhs.uk/conditions/haemochromatosis/treatment/

  There’s currently no cure for haemochromatosis, but there are treatments that can reduce the amount of iron in your body. […] This can help relieve some of the symptoms and reduce the risk of damage to organs such as the heart, liver and pancreas. […] You do not need to make any big changes to your diet, such as avoiding all foods containing iron, if you have haemochromatosis. […] This is unlikely to be of much extra help if you’re having 1 of the treatments above, and could mean you do not get all the nutrition you need. […] You’ll usually be advised to: have a generally healthy, balanced diet […] avoid breakfast cereals that have been „fortified” with extra iron […] avoid taking iron and vitamin C supplements these may be harmful for people with high iron levels […] be careful not to eat raw oysters and clams these may contain a type of bacteria that can cause serious infections in people with high iron levels […] avoid drinking excessive amounts of alcohol this can increase the level of iron in your body and put extra strain on your liver.

• #1 Hereditary Hemochromatosis | AAFP

  https://www.aafp.org/pubs/afp/issues/2013/0201/p183.html

  Hereditary hemochromatosis is an autosomal recessive disorder that disrupts the body’s regulation of iron. […] Treatment of hereditary hemochromatosis requires phlebotomy, and the frequency is guided by serial measurements of serum ferritin levels and transferrin saturation. […] Dietary modification is generally unnecessary. […] Universal screening for hereditary hemochromatosis is not recommended, but testing should be performed in first-degree relatives of patients with classical HFE-related hemochromatosis, those with evidence of active liver disease, and patients with abnormal iron study results. […] Early diagnosis and treatment may prevent morbidity and mortality. […] Published guidelines are available to guide phlebotomy frequency. […] If patients are intolerant of phlebotomy, iron chelation therapy is a second-line option.

• #1 Alcohol Abuse and Hemochromatosis | Alcohol Effects

  https://www.recoveryranch.com/addiction-blog/hemochromatosis-and-alcohol/

  Hemochromatosis, or iron overload, is a medical condition that occurs when too much of the mineral iron builds up inside the body and produces a toxic reaction. […] One of the causes of iron build-up in the body is too much alcohol. So it’s important to raise awareness about the relationship between alcohol and hemochromatosis. Long-term consumption of excessive amounts of alcohol greatly increases your risk of iron overload. […] Alcohol intake makes your body increase its level of iron storage. […] Chronic, excessive alcohol consumption frequently leads to an abnormal build-up of iron in the liver. […] If you’re abusing alcohol and you’re worried about iron overload, you can reduce your risks. Quitting alcohol is ideal. By abstaining completely, you significantly reduce the risk of hemochromatosis.

• #1 Hereditary Hemochromatosis: Rapid Evidence Review | AAFP

  https://www.aafp.org/pubs/afp/issues/2021/0900/p263.html

  Patients with hereditary hemochromatosis should be vaccinated against hepatitis A and B, if not already immune. […] Although not recommended in patients without other indications (e.g., gastroesophageal reflux disease), proton pump inhibitors lower the acidity of the stomach and reduce iron absorption. A systematic review and meta-analysis demonstrated a decreased need for phlebotomies in patients taking proton pump inhibitors for at least one year.

• #1

  https://bpac.org.nz/bt/2015/april/haemochromatosis.aspx

  The range of complications and other conditions which can arise from iron overload is diverse. Particular attention should be paid to the potential development of liver disease. Clinicians should also ensure that patients with haemochromatosis have up to date hepatitis A and B vaccinations to reduce the risk of liver damage.

• #1 Hemochromatosis | Mays Cancer Center

  https://cancer.uthscsa.edu/patient-care/cancer-center/cancer-types/iron-overload-disorder-hemochromatosis

  Iron overload disorder is often passed down in families through abnormal genes. […] Receiving care from an experienced program such as ours can lower the risk. […] Other recommendations to prevent and check for complications include: Diet and lifestyle changes: These changes may include avoiding supplements and multivitamins that raise iron levels, and quitting alcohol to protect your liver. […] Cancer screening: If you are showing signs of liver damage, regular imaging tests help us detect changes that could signal cancer.

• #1 Hemochromatosis: Symptoms, Causes & Treatment

  https://www.careinsurance.com/blog/health-insurance-articles/hemochromatosis-symptoms-causes-and-treatment

  Hemochromatosis is an inherited disease that is passed down generations. […] However, with the help of on-time medical intervention, the risk of untimely death or organ dysfunction can be reversed. […] The main aim of the treatment of hemochromatosis is to lower iron in the body. […] By making some lifestyle adjustments, you might be able to lower the risk of the disease hemochromatosis: […] Dont miss annual health checkups to monitor the presence of iron in red blood cells […] Avoid the intake of iron or vitamin supplements if you are at risk of hemochromatosis disease […] Avoid alcoholic beverages and smoking cigarettes to prevent the risk of liver damage […] Follow the doctors advice and visit his clinic for regular consultation […] Contact your doctor immediately if you face any severe symptoms. […] Hence, you should not avoid regular annual health checkups if someone in your family is diagnosed with the disease.

• #1 Researchers find potential cure for deadly iron-overload disease | News Center

  https://med.stanford.edu/news/all-news/2020/09/researchers-find-potential-cure-for-deadly-iron-overload-disease.html

  Hemochromatosis can be treated by iron chelation therapy, but for many patients this is not an option due to concurrent kidney problems. […] Chelation therapy is, unfortunately, toxic to the kidneys. […] Angelina’s liver disease had also caused kidney failure, so the chelation therapy wasn’t a safe option. […] In a recently published study in Cell Reports, Rhee and her colleagues at the Stanford School of Medicine determined that a drug called ebselen may be able to prevent heart failure in patients with iron-overload disease. […] Ebselen proved to be the best candidate for blocking the channels for iron entry, potentially protecting against heart failure.

• #1 Patient education: Hereditary hemochromatosis (Beyond the Basics) – UpToDate

  https://www.uptodate.com/contents/hereditary-hemochromatosis-beyond-the-basics/print

  Early identification and treatment of hemochromatosis can prevent complications and ensure a normal life expectancy. […] Treatment typically involves regular phlebotomy (removal of blood) since red blood cells contain a large amount of the body’s iron. […] The decision to begin phlebotomy in a person with hemochromatosis is usually based on a person’s age, sex, level of ferritin in the blood, and results of magnetic resonance imaging (MRI) or liver biopsy. When iron overload is present, phlebotomy should be started. […] Phlebotomy can effectively remove iron and resolve some, but not all, complications of hemochromatosis. If complications have not yet occurred, phlebotomy is very effective in preventing them, as long as sufficient iron is removed from the body. Most people will have a normal life expectancy.

• #1 Hereditary haemochromatosis through 150 years | Tidsskrift for Den norske legeforening

  https://tidsskriftet.no/en/2016/12/medical-history/hereditary-haemochromatosis-through-150-years

  Hereditary haemochromatosis is a congenital disorder which affects the regulation of iron metabolism thus causing increased gut absorption of iron and a gradual build-up of pathologic iron deposits in the liver and other internal organs, joint capsules and the skin (1). […] This article describes a development which over the course of 150 years has transformed haemochromatosis from a life-threatening disease into a disorder which can be picked up in its preclinical stage by routine blood tests and which allows the prevention of disease by venesection therapy. […] Preventive venesection at the preclinical stage of haemochromatosis resulted in a normal lifespan (36). […] Haemochromatosis has been transformed from a life-threatening disease to a risk factor that may be eliminated by preventive venesection therapy.

• #1 Hemochromatosis | Treatment & Management | Point of Care

  https://www.statpearls.com/point-of-care/22724

  Patients should be educated that regular treatment with phlebotomy and chelating agents can prevent most hemochromatosis complications. […] Alcohol should be avoided. Patients should also avoid supplements that contain iron or vitamin C, which promotes iron absorption. […] Early detection of hemochromatosis allows for treatment that can prevent end-organ dysfunction, resulting in minimal mortality or morbidity. […] Patients should avoid eating raw or undercooked shellfish. This is because of the risk of bacterial infections, especially those caused by Vibrio vulnificus, which thrives in iron-rich environments.

• #1 Hemochromatosis – Diet and Natural Remedies for Helping Iron Overload

  https://hemochromatosishelp.com/

  Weve realized there is a lack of clear information out there to help empower people with iron overload to take charge and to learn how to live a healthier life with hemochromatosis. […] Thats why our aim is to help you learn the safest and most effective diet and supplement strategies to help support you or your loved ones health. […] Learn how to incorporate dietary and lifestyle changes to help manage your iron overload. […] Hemochromatosis Help is proud to offer safe, effective, and unique supplements for individuals with hemochromatosis. Handpicked by a naturopathic doctor with the condition, you wont find these remedies anywhere else! […] These instructional videos help you to make sense of your diagnosis and teach you what to do about it its the only online video course in the world for patients with hemochromatosis! […] Sign-up today for in-depth and empowering articles with actionable tips to assist you on your journey with hemochromatosis!

• #1 Hemochromatosis – Knowledge @ AMBOSS

  https://www.amboss.com/us/knowledge/hemochromatosis/

  Hereditary hemochromatosis: Therapeutic phlebotomy and chelation therapy are the primary options for iron removal. […] Counseling and education: Early treatment can stabilize organ damage, improve symptoms, and increase life expectancy. […] Advise avoidance of iron and vitamin C supplements. […] Encourage strict avoidance of alcohol. […] In patients with iron overload, alcohol use significantly increases the risk of progression of both liver fibrosis and cirrhosis. […] Early treatment of iron overload may: improve fatigue and skin hyperpigmentation, reverse early organ damage (e.g., elevated liver chemistries, early cardiomyopathy), increase life expectancy. […] It may be possible to prevent the progression of advanced complications, but they cannot be reversed.

• #2 Treatment of Hemochromatosis – NIDDK

  https://www.niddk.nih.gov/health-information/liver-disease/hemochromatosis/treatment

  Phlebotomy can prevent the complications of hemochromatosis. […] You can’t prevent inheriting the gene mutations that cause primary hemochromatosis. However, early diagnosis is important since early treatment with phlebotomy can prevent complications of iron overload caused by these gene mutations. […] Secondary hemochromatosis due to blood transfusion cannot be prevented easily. However, doctors can check iron levels and start treatment with chelating agents early, before iron overload causes damage to the liver, joints, and other organs. […] If doctors know a pregnant woman is at risk for having an infant with neonatal hemochromatosis due to a family history of the condition, doctors can treat the pregnant woman with IV immunoglobulin to lower the chance that the newborn will have severe iron overload.

• #2 Patient education: Hereditary hemochromatosis (Beyond the Basics) – UpToDate

  https://www.uptodate.com/contents/hereditary-hemochromatosis-beyond-the-basics/print

  Early identification and treatment of hemochromatosis can prevent complications and ensure a normal life expectancy. […] Treatment typically involves regular phlebotomy (removal of blood) since red blood cells contain a large amount of the body’s iron. […] The decision to begin phlebotomy in a person with hemochromatosis is usually based on a person’s age, sex, level of ferritin in the blood, and results of magnetic resonance imaging (MRI) or liver biopsy. When iron overload is present, phlebotomy should be started. […] Phlebotomy can effectively remove iron and resolve some, but not all, complications of hemochromatosis. If complications have not yet occurred, phlebotomy is very effective in preventing them, as long as sufficient iron is removed from the body. Most people will have a normal life expectancy.

• #2 Haemochromatosis – British Liver Trust

  https://britishlivertrust.org.uk/information-and-support/liver-conditions/haemochromatosis/

  If you have a family history of haemochromatosis, you should see a medical professional as soon as you can. […] Relatives may be at risk and need to be encouraged to be screened by genetic testing to find out whether they carry the HFE gene mutation (though children do not need to be tested until they reach adulthood and can decide for themselves). […] It is very important that brothers and sisters are screened because they are more likely to carry both abnormal genes. […] Genetics is a complex and fast-changing area. Genetic counselling can help you to better understand the likely occurrence of haemochromatosis in your family or explain the implications of any diagnosis. […] In general people with haemochromatosis do not need specific dietary advice, although you may be cautioned to: […] Avoid taking supplements or multi-vitamins which contain iron […] Avoid taking supplements which contain vitamin C as this may increase iron absorption […] Keep alcohol intake to a minimum as this may also affect iron absorption and can accelerate liver damage.

• #2 Haemochromatosis: Symptoms, Causes, and Treatment

  https://patient.info/allergies-blood-immune/haemochromatosis-leaflet

  The need for treatment to remove excess iron does not depend on the presence of symptoms. Because of the risk of developing a serious complication such as cirrhosis, treatment to remove iron buildup from the body is very important even if there are no symptoms. […] Treatment of haemochromatosis is simple and effective. It consists of regular removal of blood which is also known as venesection therapy or phlebotomy. This may need to be done frequently (every week) at first, depending on the level of iron overload in the body. […] The clear benefit of being tested is to have treatment early before any complications occur. […] Haemochromatosis cannot be cured because the faulty gene cannot be removed. However, with early diagnosis and the right treatment, symptoms and complications can be avoided. […] Alcohol should be avoided completely if there is liver damage from haemochromatosis or if there is any other liver disease.

• #2 Hemochromatosis | Treatment & Management | Point of Care

  https://www.statpearls.com/point-of-care/22724

  Patients should be educated that regular treatment with phlebotomy and chelating agents can prevent most hemochromatosis complications. […] Alcohol should be avoided. Patients should also avoid supplements that contain iron or vitamin C, which promotes iron absorption. […] Early detection of hemochromatosis allows for treatment that can prevent end-organ dysfunction, resulting in minimal mortality or morbidity. […] Patients should avoid eating raw or undercooked shellfish. This is because of the risk of bacterial infections, especially those caused by Vibrio vulnificus, which thrives in iron-rich environments.

• #2 Patient education: Hereditary hemochromatosis (Beyond the Basics) – UpToDate

  https://www.uptodate.com/contents/hereditary-hemochromatosis-beyond-the-basics

  Early identification and treatment of hemochromatosis can prevent complications and ensure a normal life expectancy. Treatment typically involves regular phlebotomy (removal of blood) since red blood cells contain a large amount of the body’s iron. […] Treatment of hemochromatosis requires removal of excessive iron from the body, usually by periodically removing blood (referred to as „therapeutic phlebotomy”). […] Phlebotomy can effectively remove iron and resolve some, but not all, complications of hemochromatosis. If complications have not yet occurred, phlebotomy is very effective in preventing them, as long as sufficient iron is removed from the body. Most people will have a normal life expectancy. […] People who are receiving treatment for hemochromatosis do not have to follow a special diet. There is no evidence that the condition is worsened by consuming moderate amounts of iron-rich foods such as red meat and liver. […] However, people with hemochromatosis should avoid iron supplements (including multivitamins plus iron). […] Phlebotomy is appropriate and beneficial for most people with excess iron stores from hemochromatosis, including older adults and people who have no symptoms.

• #2 Hemochromatosis (Iron Overload): Causes, Symptoms, Treatment, Diet & More

  https://my.clevelandclinic.org/health/diseases/14971-hemochromatosis-iron-overload

  You cant prevent hemochromatosis, but you can get help controlling your iron levels. By identifying and treating hemochromatosis early, healthcare providers can help you avoid complications. […] Diet changes and other treatments can help ease the symptoms of hemochromatosis. They can also help prevent or delay further damage to your organs: Your healthcare provider will probably ask you to avoid supplements with iron. You may also need to stay away from foods with too much iron and limit vitamin C. Limit your alcohol consumption, too, because its not good for your liver.

• #2 Hemochromatosis | Liver Canada

  https://liver.ca/hemochromatosis/

  Hemochromatosis is a disease caused by genetics, so it cannot be prevented. However, the early detection and treatment of hemochromatosis are crucial in preventing the complications of further developments such as cirrhosis or liver cancer. […] Iron supplements, multi-vitamins, and mineral preparations containing iron should not be taken. Vitamin C, which enhances the absorption of iron when consumed with food, should be avoided or taken only four hours before or after a meal. Also, excess alcohol consumption can also enhance the absorption of iron.

• #2 Haemochromatosis – symptoms and treatment | healthdirect

  https://www.healthdirect.gov.au/haemochromatosis

  Haemochromatosis is a genetic condition, meaning you are born with the genes that cause it. But only some people with faulty genes develop the condition, and early treatment can help prevent serious problems from haemochromatosis. […] In the early stages, the main goal of treatment is to avoid iron overload. Lifestyle adjustments (see below) and monitoring may be all that is needed. […] You can help maintain your health by: avoiding iron-containing supplements, avoiding vitamin C supplements, as these increase iron absorption in your intestine, avoiding breakfast cereals containing added iron, limiting your alcohol intake or stopping drinking alcohol completely if your liver is damaged. […] Your doctor may also suggest that you are vaccinated against: hepatitis A, hepatitis B.

• #2 Treatment and Maintenance – Canadian Hemochromatosis Society

  https://www.toomuchiron.ca/hemochromatosis/treatment-and-maintenance/

  In the active de-ironing phase, reducing iron intake is almost insignificant compared to the 225 mg of iron that are being removed with each phlebotomy. […] In the maintenance phase, restricting iron intake may increase the time between phlebotomies but at no time will reducing iron in the diet replace phlebotomies as effective therapy. […] Vitamin C enhances the absorption of non-heme iron, so it should not be taken with meals. […] Raw shellfish, especially oysters, carry a bacteria called Vibrio vulnificus that can be deadly to people with iron overload because it thrives on iron.

• #2 Hereditary Hemochromatosis | AAFP

  https://www.aafp.org/pubs/afp/issues/2013/0201/p183.html

  The American Association for the Study of Liver Diseases (AASLD) recommends no meal selection adjustments, because 4 mg per day of dietary iron intake is small compared with the amount of iron that is removed with phlebotomy (250 mg per week). […] The AASLD, American Academy of Family Physicians, Centers for Disease Control and Prevention, and U.S. Preventive Services Task Force recommend against universal genetic screening for hereditary hemochromatosis. […] Hepatocellular carcinoma accounts for approximately 30 percent of deaths in patients with hereditary hemochromatosis. […] Early phlebotomy promotes cirrhotic regression and reduces morbidity and mortality.

• #2 Alcohol Abuse and Hemochromatosis | Alcohol Effects

  https://www.recoveryranch.com/addiction-blog/hemochromatosis-and-alcohol/

  Hemochromatosis, or iron overload, is a medical condition that occurs when too much of the mineral iron builds up inside the body and produces a toxic reaction. […] One of the causes of iron build-up in the body is too much alcohol. So it’s important to raise awareness about the relationship between alcohol and hemochromatosis. Long-term consumption of excessive amounts of alcohol greatly increases your risk of iron overload. […] Alcohol intake makes your body increase its level of iron storage. […] Chronic, excessive alcohol consumption frequently leads to an abnormal build-up of iron in the liver. […] If you’re abusing alcohol and you’re worried about iron overload, you can reduce your risks. Quitting alcohol is ideal. By abstaining completely, you significantly reduce the risk of hemochromatosis.

• #2 Alcohol Abuse and Hemochromatosis | Alcohol Effects

  https://www.recoveryranch.com/addiction-blog/hemochromatosis-and-alcohol/

  Drinking at moderate levels should minimize the risk of the condition developing or worsening. By reducing your alcohol intake, you can keep your iron levels within a healthy range. […] Quitting alcohol or minimizing your alcohol consumption can both help. By limiting your alcohol intake, you can relieve yourself of hemochromatosis symptoms and reduce the risk of damage to your heart, liver, and pancreas. […] Dietary changes – As well as limiting your alcohol intake, dietary changes can help maintain healthy iron levels. This includes avoiding breakfast cereals fortified with iron and iron supplements. You may also avoid raw oysters and clams, as these kinds of seafood contain bacteria that can cause infections in people with hemochromatosis. […] It’s important to treat excessive drinking before it turns into full-blown alcohol addiction, which increases your chances of developing hemochromatosis.

• #2 Hemochromatosis: Treatment, the Liver, and Hepatitis B – Hepatitis B Foundation

  https://www.hepb.org/blog/hemochromatosis-treatment-liver-hepatitis-b/

  Not everyone who has the mutant gene develops hemochromatosis. […] Hemochromatosis can easily be identified by a comprehensive look at a persons family health history, a physical exam, and a simple blood sample. […] Your doctor will then use the blood sample to run a series of tests that may include transferrin saturation (TS), serum ferritin, or liver function tests. […] In certain cases, the doctor may also perform genetic testing to see if the mutant HFE gene is present. […] Treatment for hemochromatosis is available! […] Based up tests results, family history, medical history, and the appearance of symptoms, the doctor may suggest a few different treatment methods. […] Through iron chelation therapy, patients can either receive an injection or orally consume a medication that will lower the amount of iron in your blood. […] Finally, some doctors may suggest changes to your diet, such as eating less vitamin C, avoiding alcohol and shellfish, and not taking iron supplements. […] Dietary changes are mainly used to prevent liver damage.

• #2 Hereditary haemochromatosis through 150 years | Tidsskrift for Den norske legeforening

  https://tidsskriftet.no/en/2016/12/medical-history/hereditary-haemochromatosis-through-150-years

  Hereditary haemochromatosis is a congenital disorder which affects the regulation of iron metabolism thus causing increased gut absorption of iron and a gradual build-up of pathologic iron deposits in the liver and other internal organs, joint capsules and the skin (1). […] This article describes a development which over the course of 150 years has transformed haemochromatosis from a life-threatening disease into a disorder which can be picked up in its preclinical stage by routine blood tests and which allows the prevention of disease by venesection therapy. […] Preventive venesection at the preclinical stage of haemochromatosis resulted in a normal lifespan (36). […] Haemochromatosis has been transformed from a life-threatening disease to a risk factor that may be eliminated by preventive venesection therapy.

• #2 Hereditary Hemochromatosis – with Dr. Sid Barritt | Department of Medicine

  https://www.med.unc.edu/medicine/news/chairs-corner/podcast/hereditary-hemochromatosis-barritt/

  One of the challenges with hereditary hemochromatosis is this is a population of patients who will frequently require phlebotomy or blood draws to reduce their iron. […] The goal is to identify this long before the symptoms occur and treat it. […] The treatment is actually quite simple: its phlebotomy. […] Most of the symptoms of hereditary hemochromatosis can be reversed with iron depletion in phlebotomy, especially if we start this early, before a patient is overly symptomatic. […] What Im gathering, then, is early detection, protecting ones liver from alcohol, leading a healthy life, trying to make sure that one is phlebotomized or has blood removed on some regular basis are all part of that therapeutic plan. […] If we can appropriately iron-deplete a patient, then hemochromatosis becomes sort of a back-burner diagnosis, so to speak. Patients can expect a normal life expectancy, if its caught early and there are no long-term changes to the liver, to the heart, the pancreas, et cetera. […] The therapy there would be to avoid drinking beer made from an iron drum. […] Correct, so avoid excessive dietary iron in all of its forms.

• #2 Hereditary Hemochromatosis: Symptoms & Treatment

  https://www.cancercenter.com/cancer-types/liver-cancer/risk-factors/hereditary-hemochromatosis

  Hereditary hemochromatosis (HH) is an inherited disorder that causes your bodys iron regulation to go awry. […] Plus, early treatment can help you avoid troublesome complications such as organ damage. […] The earlier youre diagnosed and seek treatment, the better your chances of preventing serious complications. […] Treatment can improve symptoms, including fatigue and abnormal liver tests. It may also help prevent organ damageand other related conditions such as liver disease, heart disease, arthritis and diabetes. […] Other ways to help prevent complications include: Stay up to date on vaccines, especially for hepatitis A and B. […] Don’t take multivitamins or vitamin C supplements.

• #2 Hereditary Hemochromatosis – Symptoms & Treatment

  https://familydoctor.org/condition/hereditary-hemochromatosis/

  Hereditary hemochromatosis can’t be prevented. But early diagnosis and treatment can improve symptoms. It also can reduce the chance of you getting more serious health conditions. For example, if you’re diagnosed and treated before you get cirrhosis or diabetes, your life expectancy should be normal. […] Other things you can do to improve reduce symptoms include: Don’t take iron supplements. Don’t take the vitamins with iron in them. Don’t take vitamin C supplements. Eat less red meat. Reduce your alcohol intake. Don’t eat raw shellfish. Don’t touch raw shellfish. It can cause a bacterial infection.

Zobacz więcej