Choroba hashimoto
Rokowania, prognozy i postęp choroby

Choroba Hashimoto, będąca autoimmunologicznym zapaleniem tarczycy (AZT), jest jedną z głównych przyczyn niedoczynności tarczycy. Wczesna diagnoza i odpowiednie leczenie, najczęściej terapią zastępczą syntetycznym hormonem T4, znacząco poprawiają rokowanie i jakość życia pacjentów. Nieleczona niedoczynność tarczycy może prowadzić do poważnych powikłań, takich jak hiperlipidemia, choroby serca, nadciśnienie tętnicze, depresja, a w skrajnych przypadkach śpiączka obrzękowa. Szczególnie istotne jest monitorowanie i kontrola niedoczynności tarczycy u kobiet w ciąży, aby zapobiec powikłaniom takim jak poronienie, przedwczesny poród czy stan przedrzucawkowy. Choroba Hashimoto ma charakter postępujący, ale przy regularnych kontrolach i leczeniu pacjenci mogą prowadzić długie i zdrowe życie.

  1. Prognozy i Rokowania w Chorobie Hashimoto
    1. Prognozy dla pacjentów z wcześnie zdiagnozowaną chorobą
    2. Historia naturalna choroby Hashimoto
  2. Powikłania nieleczonej choroby Hashimoto
    1. Powikłania w ciąży
  3. Wpływ na jakość życia
  4. Choroba Hashimoto a nowotwory tarczycy
    1. Wpływ na przebieg raka brodawkowatego tarczycy
    2. Ryzyko wystąpienia przerzutów do węzłów chłonnych
    3. Wpływ na skuteczność leczenia radioaktywnym jodem
  5. Nowe metody przewidywania ryzyka i przebiegu choroby Hashimoto
    1. Wykorzystanie wskaźnika neutrofili do limfocytów
    2. Zastosowanie uczenia maszynowego
  6. Zalecenia dotyczące prowadzenia pacjentów z chorobą Hashimoto
  7. Współtowarzyszące choroby autoimmunologiczne
    1. Kolejne rozdziały

Prognozy i Rokowania w Chorobie Hashimoto

Choroba Hashimoto (autoimmunologiczne zapalenie tarczycy, AZT) to jedna z najczęstszych przyczyn niedoczynności tarczycy. Rokowanie w tej chorobie ma kluczowe znaczenie dla planowania leczenia i oceny jakości życia pacjentów. Przy odpowiednim monitorowaniu i leczeniu, prognozy dla osób z chorobą Hashimoto są doskonałe.12

Prognozy dla pacjentów z wcześnie zdiagnozowaną chorobą

Wczesna diagnoza choroby Hashimoto znacząco poprawia rokowanie i ostatecznie zmniejsza ryzyko długoterminowych powikłań. Pacjenci zdiagnozowani na wczesnym etapie mogą otrzymać proaktywną interwencję w postaci terapii hormonalnej lub monitorowania, w zależności od tego, czy choroba Hashimoto doprowadziła już do niedoczynności tarczycy.3 Leczenie wdrożone na wczesnym etapie może poprawić jakość życia i zapobiec rozwojowi poważniejszych komplikacji.

Historia naturalna choroby Hashimoto

Choroba Hashimoto ma tendencję do powolnej progresji w ciągu wielu lat, powodując stopniowe uszkodzenie gruczołu tarczowego.4 U niektórych pacjentów stan może pozostawać stabilny przez lata. Jeśli powoli postępuje do niedoboru hormonu tarczycy (niedoczynności tarczycy), może być skutecznie leczony terapią zastępczą hormonami.5

Powikłania nieleczonej choroby Hashimoto

Nieleczona niedoczynność tarczycy w przebiegu choroby Hashimoto może prowadzić do szeregu problemów zdrowotnych, które mogą znacząco wpłynąć na rokowanie:6

  • Podwyższony poziom cholesterolu
  • Choroby serca i niewydolność serca
  • Nadciśnienie tętnicze
  • Depresja
  • Śpiączka obrzękowa – rzadkie, ale zagrażające życiu powikłanie ciężkiej niedoczynności tarczycy, w którym funkcje organizmu zwalniają do poziomu zagrażającego życiu

7

W skrajnych przypadkach ciężka nieleczona niedoczynność tarczycy może prowadzić do zmiany świadomości, śpiączki, a nawet śmierci. Takie sytuacje występują zwykle, gdy pacjenci doznają zakażenia, urazu lub przyjmują leki, takie jak opioidy.8

Powikłania w ciąży

Nieleczona niedoczynność tarczycy podczas ciąży może zwiększać ryzyko poważnych powikłań, takich jak:9

  • Poronienie
  • Przedwczesny poród
  • Martwe urodzenie
  • Niebezpieczny wzrost ciśnienia krwi w późnej ciąży (stan przedrzucawkowy)

10

Nieleczona niedoczynność tarczycy może również wpływać na wzrost płodu i rozwój mózgu. Personel medyczny pracuje z pacjentkami, aby upewnić się, że niedoczynność tarczycy jest dobrze kontrolowana podczas ciąży.11

Wpływ na jakość życia

Kobiety z chorobą Hashimoto cierpią z powodu dużego obciążenia objawami. Niedoczynność tarczycy jest tylko jednym z czynników przyczyniających się do rozwoju powiązanych stanów.12 Oznacza to, że nawet przy prawidłowym leczeniu hormonalnym, niektóre objawy mogą utrzymywać się, wpływając na ogólną jakość życia.

Choroba Hashimoto a nowotwory tarczycy

Wpływ na przebieg raka brodawkowatego tarczycy

Interesującym aspektem rokowniczym jest wpływ choroby Hashimoto na przebieg raka brodawkowatego tarczycy (PTC). Badania wskazują, że współistnienie choroby Hashimoto wydaje się mieć korzystny wpływ prognostyczny na PTC.13

Zaobserwowano, że:14

  • Choroba Hashimoto wykazuje związek ze znacznie wyższym wskaźnikiem remisji klinicznej (P≤0.001, OR 4, 95% CI 1.78-8.94)
  • PTC ze współistniejącą chorobą Hashimoto miały znacznie dłuższy okres przeżycia wolnego od nawrotu (RFS) w porównaniu z guzami bez choroby Hashimoto (P=0.004)
  • Po uwzględnieniu innych parametrów wpływających na wynik choroby w analizie jednowymiarowej (wiek w momencie diagnozy, histologia, wielkość guza i wieloogniskowość), efekt prognostyczny choroby Hashimoto pozostał istotny (P=0.006, OR 3.28, 95% CI 1.39-7.72)

15

Ryzyko wystąpienia przerzutów do węzłów chłonnych

Czynniki wpływające na przerzuty do węzłów chłonnych (LNM) u pacjentów z jednoczesnym rakiem brodawkowatym tarczycy (PTC) i chorobą Hashimoto mogą różnić się od tych u pacjentów z PTC bez choroby Hashimoto.16 Chociaż niektóre badania sugerują, że choroba Hashimoto może mieć ochronną rolę przeciwko LNM u pacjentów z PTC, nadal istnieje znaczne ryzyko LNM (28-62%) u pacjentów z jednoczesnym PTC i chorobą Hashimoto.17

Badania zidentyfikowały cztery kluczowe cechy związane z LNM u pacjentów z chorobą Hashimoto i PTC:18

  • Wiek ≤47 lat
  • Obecność zwapnień
  • Stężenie FT3 w surowicy ≥4,825 pmol/L
  • Maksymalny wymiar guza ≥1,15 cm

19

Wpływ na skuteczność leczenia radioaktywnym jodem

Choroba Hashimoto może wpływać na skuteczność leczenia radioaktywnym jodem (RAIT) w przypadku zróżnicowanego raka tarczycy (DTC) o niskim i średnim ryzyku, szczególnie zmniejszając wskaźnik powodzenia doskonałej odpowiedzi po RAIT. Nie ma jednak wpływu prognostycznego na przeżycie wolne od progresji (PFS) i przeżycie całkowite (OS).20

W analizie jednowymiarowej płeć, wiek, grupa ryzyka ATA, stymulowana tyreoglobulina (sTg) i stan choroby po 1 i 5 latach są istotnie związane z PFS. Inne cechy kliniczne i patologiczne, takie jak choroba Hashimoto, nie były istotnie związane z PFS.21

Nowe metody przewidywania ryzyka i przebiegu choroby Hashimoto

Wykorzystanie wskaźnika neutrofili do limfocytów

Podwyższony stosunek neutrofili do limfocytów (NLR) może być przydatny jako wskaźnik obecności choroby Hashimoto, szczególnie w skomplikowanych przypadkach.22 Głównym ustaleniem badań jest to, że NLR był podwyższony u pacjentów z chorobą Hashimoto w porównaniu ze zdrowymi osobami z grupy kontrolnej.23

Zwiększony NLR obserwowany u pacjentów z chorobą Hashimoto jest prawdopodobnie wynikiem przewlekłego stanu zapalnego.24 NLR jest niedrogim i łatwo dostępnym testem, dlatego sugeruje się, że pomiar NLR może być przydatny w diagnostyce choroby Hashimoto, szczególnie w skomplikowanych przypadkach, gdy diagnoza jest niepewna.25

Potrzebne są większe badania prospektywne, aby w pełni ocenić przydatność NLR w diagnostyce i ocenie wyników leczenia u pacjentów z chorobą Hashimoto.26

Zastosowanie uczenia maszynowego

Badania demonstrują możliwość wykorzystania uczenia maszynowego (ML) do dokładnego przewidywania ryzyka rozwoju choroby Hashimoto. Osiągnięte wysokie wskaźniki wydajności podkreślają potencjał tego podejścia, które może stać się cennym narzędziem klinicznym do wczesnej identyfikacji i stratyfikacji ryzyka u pacjentów podatnych na chorobę Hashimoto.27

Modele ML były w stanie przewidzieć ryzyko choroby Hashimoto z wysoką dokładnością. AUC-ROC najlepiej działającego modelu wynosiło 0,87, a AUC-PR 0,85.28

Kluczowymi cechami przyczyniającymi się do predykcji modeli ML były:29

  • Wiek
  • Płeć
  • Pochodzenie etniczne
  • Historia rodzinna choroby Hashimoto
  • Przeciwciała przeciwko peroksydazie tarczycowej (TPOAb)
  • Przeciwciała przeciwko tyreoglobulinie (TgAb)

30

Wartości SHAP wykazały, że wiek i TPOAb były najważniejszymi cechami w przewidywaniu ryzyka choroby Hashimoto.31

Zalecenia dotyczące prowadzenia pacjentów z chorobą Hashimoto

Pomimo powikłań związanych z chorobą Hashimoto, rokowanie jest wyjątkowo dobre przy wczesnej interwencji, odpowiednim leczeniu, regularnych kontrolach lekarskich i proaktywnym podejściu do możliwych powikłań.32

Leczenie zwykle obejmuje leki zawierające syntetyczny hormon tarczycy (tyroksyna). Lekarz zaleci regularne badania krwi w celu monitorowania poziomów hormonów tarczycy, aby upewnić się, że mieszczą się one w zalecanym zakresie. Pacjent będzie musiał przyjmować leki przez całe życie. Lek nie leczy choroby, ale pomaga utrzymać prawidłowy poziom hormonów tarczycy. Objawy powrócą, jeśli lek tarczycowy zostanie odstawiony.33

Regularne wizyty kontrolne u lekarza są doskonałym sposobem na zachowanie proaktywnego podejścia do zdrowia. Choroba Hashimoto ma tendencję do pogarszania się z wiekiem, ponieważ ma charakter postępujący.34

Dobrą wiadomością jest to, że choroba Hashimoto jest możliwa do opanowania, a dostępne są skuteczne opcje leczenia objawów i leczenia niedoczynności tarczycy, takie jak terapia zastępcza hormonem T4. Przy skutecznym leczeniu i rutynowych wizytach kontrolnych u lekarza, osoby z chorobą Hashimoto mogą prowadzić długie, zdrowe życie.35

Współtowarzyszące choroby autoimmunologiczne

Choroba Hashimoto może występować z innymi zaburzeniami autoimmunologicznymi. W rzadkich przypadkach może rozwinąć się rak tarczycy lub chłoniak tarczycy.36 Współwystępowanie innych chorób autoimmunologicznych może wpływać na ogólne rokowanie i wymaga kompleksowego podejścia do leczenia.

Kolejne rozdziały

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  1. 09.04.2026
  2. www.leksykon.com.pl

Materiały źródłowe

  • #1 Hashimoto’s Disease: What It Is, Symptoms & Treatment
    https://my.clevelandclinic.org/health/diseases/17665-hashimotos-disease
    With lifelong monitoring and treatment, the prognosis (outlook) for people with Hashimotos disease is excellent. […] If you have hypothyroidism from Hashimotos disease thats untreated, it can lead to certain health problems, including: High cholesterol. Heart disease and heart failure. High blood pressure. Depression. Myxedema coma. This is a rare complication of severe hypothyroidism. Your bodys functions slow down so much that it can be deadly. […] Without treatment, hypothyroidism can also cause problems during pregnancy. […] Untreated hypothyroidism during pregnancy can increase the risk of: Miscarriage. Premature birth. Stillbirth. […] Or it may cause a dangerous rise in your blood pressure in late pregnancy called preeclampsia. Untreated hypothyroidism can also affect the fetuss growth and brain development. Your providers will work with you to make sure your hypothyroidism is well-managed during pregnancy.
  • #2 Thyroid – Hashimoto’s disease | Better Health Channel
    https://www.betterhealth.vic.gov.au/health/conditionsandtreatments/thyroid-hashimotos-disease
    Hashimotos disease is a common cause of hypothyroidism (underactive thyroid). […] Treatment includes hormone replacement therapy with synthetic thyroid hormone (thyroxine), and the prognosis is usually excellent. […] With treatment, the outlook for most people with Hashimotos disease is excellent. Treatment usually includes medication with the synthetic thyroid hormone (thyroxine). The doctor will recommend regular blood tests to monitor your thyroid hormone levels to ensure they are within the recommended range. You will need to take the medication for life. Medication does not cure the condition, but helps maintain normal thyroid hormone levels. The symptoms will return if thyroid medication is stopped.
  • #3
    https://healthmatch.io/hashimotos-disease/life-expectancy-hashimotos-thyroiditis
    Even though there are complications associated with Hashimoto’s thyroiditis, the prognosis is fairly remarkable with early intervention, receiving the appropriate treatments, follow-up care with a physician, and being proactive about possible complications. […] By following these practices, those living with Hashimoto’s thyroiditis should lead a normal life. […] Getting an early diagnosis of Hashimoto’s disease can improve your outlook and ultimately reduce long-term complications. […] Those diagnosed early by a physician can receive proactive intervention with hormone therapy or monitoring, depending on whether Hashimoto’s disease has led to hypothyroidism. […] If Hashimoto’s disease has led to hypothyroidism, treatment options are available. Implementing treatment can improve your quality of life and help reduce any further complications.
  • #4
    https://healthmatch.io/hashimotos-disease/life-expectancy-hashimotos-thyroiditis
    Following up with your physician is a great way to remain proactive about your health. […] Hashimoto’s disease tends to worsen with age because it is progressive. […] The disease generally progresses slowly over many years and can cause progressive damage to the thyroid glands. […] The good news is that Hashimoto’s disease is manageable, and there are effective treatment options available to manage symptoms and treat hypothyroidism, such as T-4 hormone replacement therapy. […] With effective treatment and routine follow-ups with a physician, those with Hashimoto’s disease can lead a long, healthy life.
  • #5 Chronic thyroiditis (Hashimoto disease) Information | Mount Sinai – New York
    https://www.mountsinai.org/health-library/diseases-conditions/chronic-thyroiditis-hashimoto-disease
    The disease stays stable for years. If it does slowly progress to thyroid hormone deficiency (hypothyroidism), it can be treated with hormone replacement therapy. […] This condition can occur with other autoimmune disorders. In rare cases, thyroid cancer or thyroid lymphoma may develop. […] Severe untreated hypothyroidism can lead to a change in consciousness, coma, and death. This usually occurs if people get an infection, are injured, or take medicines, such as opioids.
  • #6 Hashimoto’s Disease: What It Is, Symptoms & Treatment
    https://my.clevelandclinic.org/health/diseases/17665-hashimotos-disease
    With lifelong monitoring and treatment, the prognosis (outlook) for people with Hashimotos disease is excellent. […] If you have hypothyroidism from Hashimotos disease thats untreated, it can lead to certain health problems, including: High cholesterol. Heart disease and heart failure. High blood pressure. Depression. Myxedema coma. This is a rare complication of severe hypothyroidism. Your bodys functions slow down so much that it can be deadly. […] Without treatment, hypothyroidism can also cause problems during pregnancy. […] Untreated hypothyroidism during pregnancy can increase the risk of: Miscarriage. Premature birth. Stillbirth. […] Or it may cause a dangerous rise in your blood pressure in late pregnancy called preeclampsia. Untreated hypothyroidism can also affect the fetuss growth and brain development. Your providers will work with you to make sure your hypothyroidism is well-managed during pregnancy.
  • #7 Hashimoto’s Disease: What It Is, Symptoms & Treatment
    https://my.clevelandclinic.org/health/diseases/17665-hashimotos-disease
    With lifelong monitoring and treatment, the prognosis (outlook) for people with Hashimotos disease is excellent. […] If you have hypothyroidism from Hashimotos disease thats untreated, it can lead to certain health problems, including: High cholesterol. Heart disease and heart failure. High blood pressure. Depression. Myxedema coma. This is a rare complication of severe hypothyroidism. Your bodys functions slow down so much that it can be deadly. […] Without treatment, hypothyroidism can also cause problems during pregnancy. […] Untreated hypothyroidism during pregnancy can increase the risk of: Miscarriage. Premature birth. Stillbirth. […] Or it may cause a dangerous rise in your blood pressure in late pregnancy called preeclampsia. Untreated hypothyroidism can also affect the fetuss growth and brain development. Your providers will work with you to make sure your hypothyroidism is well-managed during pregnancy.
  • #8 Chronic thyroiditis (Hashimoto disease) Information | Mount Sinai – New York
    https://www.mountsinai.org/health-library/diseases-conditions/chronic-thyroiditis-hashimoto-disease
    The disease stays stable for years. If it does slowly progress to thyroid hormone deficiency (hypothyroidism), it can be treated with hormone replacement therapy. […] This condition can occur with other autoimmune disorders. In rare cases, thyroid cancer or thyroid lymphoma may develop. […] Severe untreated hypothyroidism can lead to a change in consciousness, coma, and death. This usually occurs if people get an infection, are injured, or take medicines, such as opioids.
  • #9 Hashimoto’s Disease: What It Is, Symptoms & Treatment
    https://my.clevelandclinic.org/health/diseases/17665-hashimotos-disease
    With lifelong monitoring and treatment, the prognosis (outlook) for people with Hashimotos disease is excellent. […] If you have hypothyroidism from Hashimotos disease thats untreated, it can lead to certain health problems, including: High cholesterol. Heart disease and heart failure. High blood pressure. Depression. Myxedema coma. This is a rare complication of severe hypothyroidism. Your bodys functions slow down so much that it can be deadly. […] Without treatment, hypothyroidism can also cause problems during pregnancy. […] Untreated hypothyroidism during pregnancy can increase the risk of: Miscarriage. Premature birth. Stillbirth. […] Or it may cause a dangerous rise in your blood pressure in late pregnancy called preeclampsia. Untreated hypothyroidism can also affect the fetuss growth and brain development. Your providers will work with you to make sure your hypothyroidism is well-managed during pregnancy.
  • #10 Hashimoto’s Disease: What It Is, Symptoms & Treatment
    https://my.clevelandclinic.org/health/diseases/17665-hashimotos-disease
    With lifelong monitoring and treatment, the prognosis (outlook) for people with Hashimotos disease is excellent. […] If you have hypothyroidism from Hashimotos disease thats untreated, it can lead to certain health problems, including: High cholesterol. Heart disease and heart failure. High blood pressure. Depression. Myxedema coma. This is a rare complication of severe hypothyroidism. Your bodys functions slow down so much that it can be deadly. […] Without treatment, hypothyroidism can also cause problems during pregnancy. […] Untreated hypothyroidism during pregnancy can increase the risk of: Miscarriage. Premature birth. Stillbirth. […] Or it may cause a dangerous rise in your blood pressure in late pregnancy called preeclampsia. Untreated hypothyroidism can also affect the fetuss growth and brain development. Your providers will work with you to make sure your hypothyroidism is well-managed during pregnancy.
  • #11 Hashimoto’s Disease: What It Is, Symptoms & Treatment
    https://my.clevelandclinic.org/health/diseases/17665-hashimotos-disease
    With lifelong monitoring and treatment, the prognosis (outlook) for people with Hashimotos disease is excellent. […] If you have hypothyroidism from Hashimotos disease thats untreated, it can lead to certain health problems, including: High cholesterol. Heart disease and heart failure. High blood pressure. Depression. Myxedema coma. This is a rare complication of severe hypothyroidism. Your bodys functions slow down so much that it can be deadly. […] Without treatment, hypothyroidism can also cause problems during pregnancy. […] Untreated hypothyroidism during pregnancy can increase the risk of: Miscarriage. Premature birth. Stillbirth. […] Or it may cause a dangerous rise in your blood pressure in late pregnancy called preeclampsia. Untreated hypothyroidism can also affect the fetuss growth and brain development. Your providers will work with you to make sure your hypothyroidism is well-managed during pregnancy.
  • #12 Hashimoto’s thyroiditis affects symptom load and quality of life unrelated to hypothyroidism: a prospective case-control study in women undergoing thyroidectomy for benign goiter – PubMed
    https://pubmed.ncbi.nlm.nih.gov/21186954/
    Hashimoto’s thyroiditis (HT) is a common disease, and is the most prevalent cause of hypothyroidism. […] Women with HT suffer from a high symptom load. Hypothyroidism is only a contributing factor to the development of associated conditions.
  • #13 Hashimoto’s thyroiditis predicts outcome in intrathyroidal papillary thyroid cancer in: Endocrine-Related Cancer Volume 24 Issue 9 (2017)
    https://erc.bioscientifica.com/view/journals/erc/24/9/485.xml
    Hashimotos thyroiditis (HT) seems to have favourable prognostic impact on papillary thyroid cancer (PTC), but data were obtained analysing all disease stages. […] HT showed relationship with significantly higher rate of clinical remission (P0.001, OR 4, 95% CI 1.788.94). PTCs with concomitant HT had significantly longer RFS, as compared with non-HT tumours (P=0.004). […] After adjustment for other parameters affecting disease outcome at univariate analysis (age at diagnosis, histology, tumour size and multifocality), prognostic effect of HT remained significant (P=0.006, OR 3.28, 95% CI 1.397.72). […] In conclusion, our data show that HT represents an independent prognostic parameter in intrathyroidal PTC, but cannot improve prognostic specificity.
  • #14 Hashimoto’s thyroiditis predicts outcome in intrathyroidal papillary thyroid cancer in: Endocrine-Related Cancer Volume 24 Issue 9 (2017)
    https://erc.bioscientifica.com/view/journals/erc/24/9/485.xml
    Hashimotos thyroiditis (HT) seems to have favourable prognostic impact on papillary thyroid cancer (PTC), but data were obtained analysing all disease stages. […] HT showed relationship with significantly higher rate of clinical remission (P0.001, OR 4, 95% CI 1.788.94). PTCs with concomitant HT had significantly longer RFS, as compared with non-HT tumours (P=0.004). […] After adjustment for other parameters affecting disease outcome at univariate analysis (age at diagnosis, histology, tumour size and multifocality), prognostic effect of HT remained significant (P=0.006, OR 3.28, 95% CI 1.397.72). […] In conclusion, our data show that HT represents an independent prognostic parameter in intrathyroidal PTC, but cannot improve prognostic specificity.
  • #15 Hashimoto’s thyroiditis predicts outcome in intrathyroidal papillary thyroid cancer in: Endocrine-Related Cancer Volume 24 Issue 9 (2017)
    https://erc.bioscientifica.com/view/journals/erc/24/9/485.xml
    Hashimotos thyroiditis (HT) seems to have favourable prognostic impact on papillary thyroid cancer (PTC), but data were obtained analysing all disease stages. […] HT showed relationship with significantly higher rate of clinical remission (P0.001, OR 4, 95% CI 1.788.94). PTCs with concomitant HT had significantly longer RFS, as compared with non-HT tumours (P=0.004). […] After adjustment for other parameters affecting disease outcome at univariate analysis (age at diagnosis, histology, tumour size and multifocality), prognostic effect of HT remained significant (P=0.006, OR 3.28, 95% CI 1.397.72). […] In conclusion, our data show that HT represents an independent prognostic parameter in intrathyroidal PTC, but cannot improve prognostic specificity.
  • #16 Predicting lymph node metastasis in papillary thyroid carcinoma with Hashimoto’s thyroiditis using regression and network analysis | Scientific Reports
    https://www.nature.com/articles/s41598-024-78179-8
    The comprehensive study of the relationship between lymph node metastasis (LNM) and its associated factors in patients with concurrent papillary thyroid carcinoma (PTC) and Hashimotos thyroiditis (HT) remains insufficient. […] Current research suggests that the factors influencing LNM in PTC patients with concurrent HT may differ from those in PTC patients without HT. […] The presence of LNM, the number of LNM, and the regions affected significantly influence the surgical approach and prognosis for PTC patients. […] Although some studies suggest that HT may have a protective role against LNM in PTC patients, there remains a considerable risk of LNM (28-62%) in patients with concurrent PTC and HT. […] This study innovatively combined regression models and network analysis to investigate factors related to LNM in patients with PTC and HT, providing a theoretical basis for predicting preoperative LNM in future clinical practice.
  • #17 Predicting lymph node metastasis in papillary thyroid carcinoma with Hashimoto’s thyroiditis using regression and network analysis | Scientific Reports
    https://www.nature.com/articles/s41598-024-78179-8
    The comprehensive study of the relationship between lymph node metastasis (LNM) and its associated factors in patients with concurrent papillary thyroid carcinoma (PTC) and Hashimotos thyroiditis (HT) remains insufficient. […] Current research suggests that the factors influencing LNM in PTC patients with concurrent HT may differ from those in PTC patients without HT. […] The presence of LNM, the number of LNM, and the regions affected significantly influence the surgical approach and prognosis for PTC patients. […] Although some studies suggest that HT may have a protective role against LNM in PTC patients, there remains a considerable risk of LNM (28-62%) in patients with concurrent PTC and HT. […] This study innovatively combined regression models and network analysis to investigate factors related to LNM in patients with PTC and HT, providing a theoretical basis for predicting preoperative LNM in future clinical practice.
  • #18 Predicting lymph node metastasis in papillary thyroid carcinoma with Hashimoto’s thyroiditis using regression and network analysis | Scientific Reports
    https://www.nature.com/articles/s41598-024-78179-8
    We identified four key characteristics associated with LNM in patients with HT and PTC: age 47 years, calcifications, serum FT3 4.825 pmol/L, and TMD 1.15 cm. […] The regression model identified distinct independent risk factors in two subgroups of LNM severity. […] The finding that lower serum FT4 levels are linked to lateral LNM suggests a complex interplay of thyroid hormones affecting tumor behavior. […] Overall, our results provide a theoretical basis for predicting preoperative LNM in patients with PTC and HT in future clinical practice.
  • #19 Predicting lymph node metastasis in papillary thyroid carcinoma with Hashimoto’s thyroiditis using regression and network analysis | Scientific Reports
    https://www.nature.com/articles/s41598-024-78179-8
    We identified four key characteristics associated with LNM in patients with HT and PTC: age 47 years, calcifications, serum FT3 4.825 pmol/L, and TMD 1.15 cm. […] The regression model identified distinct independent risk factors in two subgroups of LNM severity. […] The finding that lower serum FT4 levels are linked to lateral LNM suggests a complex interplay of thyroid hormones affecting tumor behavior. […] Overall, our results provide a theoretical basis for predicting preoperative LNM in patients with PTC and HT in future clinical practice.
  • #20
    https://link.springer.com/article/10.1007/s12149-021-01644-1
    The aim of this study was to investigate the potential role of Hashimoto thyroiditis (HT) in predicting 1-year and 5-year treatment response after RAIT and prognosis. […] HT may affect the efficacy of RAIT in low to intermediate risk DTC, particularly reducing the successful rate of excellent response after RAIT. Instead, HT did not have a prognostic impact such as stimulated sTg. […] In univariate analysis, gender, age, ATA class risk group, sTg and disease status after 1 and 5 years are significantly related with PFS. The other clinical and pathological features, like HT, were not significantly associated with PFS. […] On the other hand, HT does not show a prognostic role in predicting PFS and OS. Other parameters, like age at diagnosis, sTg, and disease status after first-line therapy were significantly correlated with the risk of recurrence.
  • #21
    https://link.springer.com/article/10.1007/s12149-021-01644-1
    The aim of this study was to investigate the potential role of Hashimoto thyroiditis (HT) in predicting 1-year and 5-year treatment response after RAIT and prognosis. […] HT may affect the efficacy of RAIT in low to intermediate risk DTC, particularly reducing the successful rate of excellent response after RAIT. Instead, HT did not have a prognostic impact such as stimulated sTg. […] In univariate analysis, gender, age, ATA class risk group, sTg and disease status after 1 and 5 years are significantly related with PFS. The other clinical and pathological features, like HT, were not significantly associated with PFS. […] On the other hand, HT does not show a prognostic role in predicting PFS and OS. Other parameters, like age at diagnosis, sTg, and disease status after first-line therapy were significantly correlated with the risk of recurrence.
  • #22 SciELO Brazil – Elevated neutrophil-to-lymphocyte ratio in the diagnosis of Hashimoto’s thyroiditis Elevated neutrophil-to-lymphocyte ratio in the diagnosis of Hashimoto’s thyroiditis
    https://www.scielo.br/j/ramb/a/8dhhtMMVftx58Knm3vSZZLP/
    Increased NLR may be useful as an indicator of the presence of HT, especially in complicated cases. […] Larger, prospective studies are required to determine its usefulness in assessing diagnostic potential and treatment outcomes in HT patients. […] The main finding of our study is that NLR was elevated in HT patients compared with the healthy control subjects. […] Therefore, the increased NLR seen in HT patients compared with controls in this study is likely to be a result of chronic inflammation. […] Our study was limited by its retrospective design, which could lead to selection bias, and by the small study cohort that made conclusive interpretation of the results difficult. […] NLR is an inexpensive and easily accessible test and, therefore, we suggest that measurement of NLR may be useful in the diagnosis of HT, especially in complicated cases when a diagnosis is uncertain. […] Larger prospective studies are required to fully assess the usefulness of NLR to diagnose and assess treatment outcomes in HT patients.
  • #23 SciELO Brazil – Elevated neutrophil-to-lymphocyte ratio in the diagnosis of Hashimoto’s thyroiditis Elevated neutrophil-to-lymphocyte ratio in the diagnosis of Hashimoto’s thyroiditis
    https://www.scielo.br/j/ramb/a/8dhhtMMVftx58Knm3vSZZLP/
    Increased NLR may be useful as an indicator of the presence of HT, especially in complicated cases. […] Larger, prospective studies are required to determine its usefulness in assessing diagnostic potential and treatment outcomes in HT patients. […] The main finding of our study is that NLR was elevated in HT patients compared with the healthy control subjects. […] Therefore, the increased NLR seen in HT patients compared with controls in this study is likely to be a result of chronic inflammation. […] Our study was limited by its retrospective design, which could lead to selection bias, and by the small study cohort that made conclusive interpretation of the results difficult. […] NLR is an inexpensive and easily accessible test and, therefore, we suggest that measurement of NLR may be useful in the diagnosis of HT, especially in complicated cases when a diagnosis is uncertain. […] Larger prospective studies are required to fully assess the usefulness of NLR to diagnose and assess treatment outcomes in HT patients.
  • #24 SciELO Brazil – Elevated neutrophil-to-lymphocyte ratio in the diagnosis of Hashimoto’s thyroiditis Elevated neutrophil-to-lymphocyte ratio in the diagnosis of Hashimoto’s thyroiditis
    https://www.scielo.br/j/ramb/a/8dhhtMMVftx58Knm3vSZZLP/
    Increased NLR may be useful as an indicator of the presence of HT, especially in complicated cases. […] Larger, prospective studies are required to determine its usefulness in assessing diagnostic potential and treatment outcomes in HT patients. […] The main finding of our study is that NLR was elevated in HT patients compared with the healthy control subjects. […] Therefore, the increased NLR seen in HT patients compared with controls in this study is likely to be a result of chronic inflammation. […] Our study was limited by its retrospective design, which could lead to selection bias, and by the small study cohort that made conclusive interpretation of the results difficult. […] NLR is an inexpensive and easily accessible test and, therefore, we suggest that measurement of NLR may be useful in the diagnosis of HT, especially in complicated cases when a diagnosis is uncertain. […] Larger prospective studies are required to fully assess the usefulness of NLR to diagnose and assess treatment outcomes in HT patients.
  • #25 SciELO Brazil – Elevated neutrophil-to-lymphocyte ratio in the diagnosis of Hashimoto’s thyroiditis Elevated neutrophil-to-lymphocyte ratio in the diagnosis of Hashimoto’s thyroiditis
    https://www.scielo.br/j/ramb/a/8dhhtMMVftx58Knm3vSZZLP/
    Increased NLR may be useful as an indicator of the presence of HT, especially in complicated cases. […] Larger, prospective studies are required to determine its usefulness in assessing diagnostic potential and treatment outcomes in HT patients. […] The main finding of our study is that NLR was elevated in HT patients compared with the healthy control subjects. […] Therefore, the increased NLR seen in HT patients compared with controls in this study is likely to be a result of chronic inflammation. […] Our study was limited by its retrospective design, which could lead to selection bias, and by the small study cohort that made conclusive interpretation of the results difficult. […] NLR is an inexpensive and easily accessible test and, therefore, we suggest that measurement of NLR may be useful in the diagnosis of HT, especially in complicated cases when a diagnosis is uncertain. […] Larger prospective studies are required to fully assess the usefulness of NLR to diagnose and assess treatment outcomes in HT patients.
  • #26 SciELO Brazil – Elevated neutrophil-to-lymphocyte ratio in the diagnosis of Hashimoto’s thyroiditis Elevated neutrophil-to-lymphocyte ratio in the diagnosis of Hashimoto’s thyroiditis
    https://www.scielo.br/j/ramb/a/8dhhtMMVftx58Knm3vSZZLP/
    Increased NLR may be useful as an indicator of the presence of HT, especially in complicated cases. […] Larger, prospective studies are required to determine its usefulness in assessing diagnostic potential and treatment outcomes in HT patients. […] The main finding of our study is that NLR was elevated in HT patients compared with the healthy control subjects. […] Therefore, the increased NLR seen in HT patients compared with controls in this study is likely to be a result of chronic inflammation. […] Our study was limited by its retrospective design, which could lead to selection bias, and by the small study cohort that made conclusive interpretation of the results difficult. […] NLR is an inexpensive and easily accessible test and, therefore, we suggest that measurement of NLR may be useful in the diagnosis of HT, especially in complicated cases when a diagnosis is uncertain. […] Larger prospective studies are required to fully assess the usefulness of NLR to diagnose and assess treatment outcomes in HT patients.
  • #27 Machine Learning-Based Prediction of Hashimoto’s Thyroiditis Development Risk | medRxiv
    https://www.medrxiv.org/content/10.1101/2024.03.15.24304346v1.full-text
    This study demonstrates the feasibility of utilizing ML for accurate prediction of HT risk. The high performance metrics achieved highlight the potential for this approach to become a valuable clinical tool for early identification and risk stratification of patients susceptible to HT. […] The ML models were able to predict HT risk with high accuracy. The AUC-ROC of the best-performing model was 0.87, and the AUC-PR was 0.85. […] The key features contributing to the predictions of the ML models were age, sex, ethnicity, family history of HT, TPOAb, and TgAb. The SHAP values showed that age and TPOAb were the most important features for predicting HT risk. […] Our investigation demonstrates the potential of ML algorithms in predicting the risk of developing HT. The employed algorithms achieved promising results, as evidenced by robust performance metrics. Therefore, our study successfully implemented these algorithms, yielding satisfactory performance during the evaluation stage, thus paving the way for further exploration of their utility in clinical settings. Continued research is warranted to refine these models and integrate them into comprehensive risk assessment tools for HT.
  • #28 Machine Learning-Based Prediction of Hashimoto’s Thyroiditis Development Risk | medRxiv
    https://www.medrxiv.org/content/10.1101/2024.03.15.24304346v1.full-text
    This study demonstrates the feasibility of utilizing ML for accurate prediction of HT risk. The high performance metrics achieved highlight the potential for this approach to become a valuable clinical tool for early identification and risk stratification of patients susceptible to HT. […] The ML models were able to predict HT risk with high accuracy. The AUC-ROC of the best-performing model was 0.87, and the AUC-PR was 0.85. […] The key features contributing to the predictions of the ML models were age, sex, ethnicity, family history of HT, TPOAb, and TgAb. The SHAP values showed that age and TPOAb were the most important features for predicting HT risk. […] Our investigation demonstrates the potential of ML algorithms in predicting the risk of developing HT. The employed algorithms achieved promising results, as evidenced by robust performance metrics. Therefore, our study successfully implemented these algorithms, yielding satisfactory performance during the evaluation stage, thus paving the way for further exploration of their utility in clinical settings. Continued research is warranted to refine these models and integrate them into comprehensive risk assessment tools for HT.
  • #29 Machine Learning-Based Prediction of Hashimoto’s Thyroiditis Development Risk | medRxiv
    https://www.medrxiv.org/content/10.1101/2024.03.15.24304346v1.full-text
    This study demonstrates the feasibility of utilizing ML for accurate prediction of HT risk. The high performance metrics achieved highlight the potential for this approach to become a valuable clinical tool for early identification and risk stratification of patients susceptible to HT. […] The ML models were able to predict HT risk with high accuracy. The AUC-ROC of the best-performing model was 0.87, and the AUC-PR was 0.85. […] The key features contributing to the predictions of the ML models were age, sex, ethnicity, family history of HT, TPOAb, and TgAb. The SHAP values showed that age and TPOAb were the most important features for predicting HT risk. […] Our investigation demonstrates the potential of ML algorithms in predicting the risk of developing HT. The employed algorithms achieved promising results, as evidenced by robust performance metrics. Therefore, our study successfully implemented these algorithms, yielding satisfactory performance during the evaluation stage, thus paving the way for further exploration of their utility in clinical settings. Continued research is warranted to refine these models and integrate them into comprehensive risk assessment tools for HT.
  • #30 Machine Learning-Based Prediction of Hashimoto’s Thyroiditis Development Risk | medRxiv
    https://www.medrxiv.org/content/10.1101/2024.03.15.24304346v1.full-text
    This study demonstrates the feasibility of utilizing ML for accurate prediction of HT risk. The high performance metrics achieved highlight the potential for this approach to become a valuable clinical tool for early identification and risk stratification of patients susceptible to HT. […] The ML models were able to predict HT risk with high accuracy. The AUC-ROC of the best-performing model was 0.87, and the AUC-PR was 0.85. […] The key features contributing to the predictions of the ML models were age, sex, ethnicity, family history of HT, TPOAb, and TgAb. The SHAP values showed that age and TPOAb were the most important features for predicting HT risk. […] Our investigation demonstrates the potential of ML algorithms in predicting the risk of developing HT. The employed algorithms achieved promising results, as evidenced by robust performance metrics. Therefore, our study successfully implemented these algorithms, yielding satisfactory performance during the evaluation stage, thus paving the way for further exploration of their utility in clinical settings. Continued research is warranted to refine these models and integrate them into comprehensive risk assessment tools for HT.
  • #31 Machine Learning-Based Prediction of Hashimoto’s Thyroiditis Development Risk | medRxiv
    https://www.medrxiv.org/content/10.1101/2024.03.15.24304346v1.full-text
    This study demonstrates the feasibility of utilizing ML for accurate prediction of HT risk. The high performance metrics achieved highlight the potential for this approach to become a valuable clinical tool for early identification and risk stratification of patients susceptible to HT. […] The ML models were able to predict HT risk with high accuracy. The AUC-ROC of the best-performing model was 0.87, and the AUC-PR was 0.85. […] The key features contributing to the predictions of the ML models were age, sex, ethnicity, family history of HT, TPOAb, and TgAb. The SHAP values showed that age and TPOAb were the most important features for predicting HT risk. […] Our investigation demonstrates the potential of ML algorithms in predicting the risk of developing HT. The employed algorithms achieved promising results, as evidenced by robust performance metrics. Therefore, our study successfully implemented these algorithms, yielding satisfactory performance during the evaluation stage, thus paving the way for further exploration of their utility in clinical settings. Continued research is warranted to refine these models and integrate them into comprehensive risk assessment tools for HT.
  • #32
    https://healthmatch.io/hashimotos-disease/life-expectancy-hashimotos-thyroiditis
    Even though there are complications associated with Hashimoto’s thyroiditis, the prognosis is fairly remarkable with early intervention, receiving the appropriate treatments, follow-up care with a physician, and being proactive about possible complications. […] By following these practices, those living with Hashimoto’s thyroiditis should lead a normal life. […] Getting an early diagnosis of Hashimoto’s disease can improve your outlook and ultimately reduce long-term complications. […] Those diagnosed early by a physician can receive proactive intervention with hormone therapy or monitoring, depending on whether Hashimoto’s disease has led to hypothyroidism. […] If Hashimoto’s disease has led to hypothyroidism, treatment options are available. Implementing treatment can improve your quality of life and help reduce any further complications.
  • #33 Thyroid – Hashimoto’s disease | Better Health Channel
    https://www.betterhealth.vic.gov.au/health/conditionsandtreatments/thyroid-hashimotos-disease
    Hashimotos disease is a common cause of hypothyroidism (underactive thyroid). […] Treatment includes hormone replacement therapy with synthetic thyroid hormone (thyroxine), and the prognosis is usually excellent. […] With treatment, the outlook for most people with Hashimotos disease is excellent. Treatment usually includes medication with the synthetic thyroid hormone (thyroxine). The doctor will recommend regular blood tests to monitor your thyroid hormone levels to ensure they are within the recommended range. You will need to take the medication for life. Medication does not cure the condition, but helps maintain normal thyroid hormone levels. The symptoms will return if thyroid medication is stopped.
  • #34
    https://healthmatch.io/hashimotos-disease/life-expectancy-hashimotos-thyroiditis
    Following up with your physician is a great way to remain proactive about your health. […] Hashimoto’s disease tends to worsen with age because it is progressive. […] The disease generally progresses slowly over many years and can cause progressive damage to the thyroid glands. […] The good news is that Hashimoto’s disease is manageable, and there are effective treatment options available to manage symptoms and treat hypothyroidism, such as T-4 hormone replacement therapy. […] With effective treatment and routine follow-ups with a physician, those with Hashimoto’s disease can lead a long, healthy life.
  • #35
    https://healthmatch.io/hashimotos-disease/life-expectancy-hashimotos-thyroiditis
    Following up with your physician is a great way to remain proactive about your health. […] Hashimoto’s disease tends to worsen with age because it is progressive. […] The disease generally progresses slowly over many years and can cause progressive damage to the thyroid glands. […] The good news is that Hashimoto’s disease is manageable, and there are effective treatment options available to manage symptoms and treat hypothyroidism, such as T-4 hormone replacement therapy. […] With effective treatment and routine follow-ups with a physician, those with Hashimoto’s disease can lead a long, healthy life.
  • #36 Chronic thyroiditis (Hashimoto disease) Information | Mount Sinai – New York
    https://www.mountsinai.org/health-library/diseases-conditions/chronic-thyroiditis-hashimoto-disease
    The disease stays stable for years. If it does slowly progress to thyroid hormone deficiency (hypothyroidism), it can be treated with hormone replacement therapy. […] This condition can occur with other autoimmune disorders. In rare cases, thyroid cancer or thyroid lymphoma may develop. […] Severe untreated hypothyroidism can lead to a change in consciousness, coma, and death. This usually occurs if people get an infection, are injured, or take medicines, such as opioids.

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