Materiały źródłowe

• #1 Alpha-gal syndrome – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/alpha-gal-syndrome/diagnosis-treatment/drc-20428705

  Alpha-gal syndrome treatment involves avoiding the foods that cause your reaction. Always check the ingredient labels on store-bought foods. Make sure they don’t have red meat or meat-based ingredients, such as: […] Be extra careful when you eat at restaurants and social get-togethers. Many people don’t understand how serious an allergic food reaction can be. And few people know that meat allergies exist. Even a small amount of red meat can cause a serious reaction. […] For a serious allergic reaction, you may need a shot of epinephrine and emergency care. Many people with allergies carry a device called an epinephrine auto-injector. It’s a syringe and concealed needle that injects a single dose of medication when you press it against your thigh. If you’ve been diagnosed with alpha-gal syndrome, your doctor or allergist likely will prescribe an epinephrine auto-injector. […] Symptoms of alpha-gal syndrome may lessen or even disappear over time. This is especially true if you don’t get any more bites from ticks that carry alpha-gal. Some people with this condition can eat mammal food products again after 1 to 2 years if they don’t get any more tick bites.

• #2 Alpha-gal Syndrome (AGS) > Fact Sheets > Yale Medicine

  https://www.yalemedicine.org/conditions/alpha-gal-syndrome-ags

  Treatment involves medications for allergic reactions, avoiding consumption of mammalian meat and foods and medications that contain alpha-gal, avoiding additional tick bites […] While there is no treatment for AGS, people with an allergy can prevent allergic reactions from occurring by avoiding meats and other products that contain alpha-gal. […] While there is no treatment or cure for AGS, treatments are available for the allergic reactions, including anaphylaxis, that people with the condition can experience. […] Treatments for allergic reactions caused by alpha-gal exposure. These treatments include epinephrine (also known as adrenaline), antihistamines, and oral corticosteroids. […] Avoidance of additional tick bites. People in the U.S. who are allergic to alpha-gal should avoid new bites from the lone star tick because they increase the level of IgE antibodies against alpha-gal, thereby increasing sensitivity to alpha-gal.

• #3 Alpha-gal Syndrome: Causes, Diagnosis & Treatment

  https://my.clevelandclinic.org/health/diseases/24493-alpha-gal-syndrome

  Currently, there isnt a cure for AGS. Work with your healthcare provider to find ways to avoid triggers and stay healthy. […] There isnt a cure for alpha-gal syndrome. Early detection can help you and your healthcare provider develop a management plan specific to your needs. […] Treatment for alpha-gal (AGS) syndrome typically involves avoiding foods with alpha-gal and taking medications to manage symptoms that may occur with accidental exposure. Your healthcare provider can work with you to help you avoid products and medications containing alpha-gal. […] Physicians may recommend rescue medications, such as antihistamines or an epinephrine (adrenaline) injector. Other treatments depend on your symptoms. Oral cromolyn solution can help with GI symptoms. […] The outlook for alpha-gal syndrome is good when you follow your treatment plan and avoid triggers.

• #4 Alpha-gal Syndrome: Causes, Diagnosis & Treatment

  https://my.clevelandclinic.org/health/diseases/24493-alpha-gal-syndrome

  Currently, there isnt a cure for AGS. Work with your healthcare provider to find ways to avoid triggers and stay healthy. […] There isnt a cure for alpha-gal syndrome. Early detection can help you and your healthcare provider develop a management plan specific to your needs. […] Treatment for alpha-gal (AGS) syndrome typically involves avoiding foods with alpha-gal and taking medications to manage symptoms that may occur with accidental exposure. Your healthcare provider can work with you to help you avoid products and medications containing alpha-gal. […] Physicians may recommend rescue medications, such as antihistamines or an epinephrine (adrenaline) injector. Other treatments depend on your symptoms. Oral cromolyn solution can help with GI symptoms. […] The outlook for alpha-gal syndrome is good when you follow your treatment plan and avoid triggers.

• #5 Diagnosis and management of patients with the α-Gal syndrome

  https://pmc.ncbi.nlm.nih.gov/articles/PMC6980324/

  The -Gal syndrome has many novel features that are relevant to diagnosis and management. In general, the diagnosis also dictates the primary treatment, i.e. avoiding mammalian meat and also dairy in some cases. […] Blood levels of IgE to -Gal often drop in patients who avoid recurrent tick bites, but the rate of decline is variable. Similarly, the delay before reactions is variable and the severity of the allergic reactions is not predicted by the delay or the titer of specific IgE. […] The primary advice for newly diagnosed cases of the syndrome is to completely avoid meat of mammals. […] Avoiding products such as milk, yogurt, and ice cream is relatively easy because there are alternatives made from almond, oat, cashew or other non-mammalian sources. […] The argument about a dairy-free diet changes completely if consumption of -Gal containing products can contribute to inflammation without giving rise to allergic symptoms.

• #6 Alpha-gal Syndrome (AGS) > Fact Sheets > Yale Medicine

  https://www.yalemedicine.org/conditions/alpha-gal-syndrome-ags

  Avoidance of meat, dairy products, and other products that contain alpha-gal. Individuals diagnosed with AGS should completely avoid the consumption of mammalian meat, including beef, pork, lamb, venison, goat, and rabbit. […] Because around 5% to 20% of people with AGS have allergic reactions to dairy products (which contain alpha-gal, though at lower levels than meat), health care providers may also recommend that some individuals with AGS avoid consuming dairy products, in particular those whose symptoms are not adequately controlled through meat avoidance alone. […] Many other products and medications may also contain alpha-gal. People with AGS should consult with their health care provider about which foods or other products they should avoid. […] Your doctor will discuss your history of reactions and monitor blood tests to help determine whether alpha-gal-containing foods can be eaten again.

• #7 Alpha-gal Syndrome (AGS) > Fact Sheets > Yale Medicine

  https://www.yalemedicine.org/conditions/alpha-gal-syndrome-ags

  Avoidance of meat, dairy products, and other products that contain alpha-gal. Individuals diagnosed with AGS should completely avoid the consumption of mammalian meat, including beef, pork, lamb, venison, goat, and rabbit. […] Because around 5% to 20% of people with AGS have allergic reactions to dairy products (which contain alpha-gal, though at lower levels than meat), health care providers may also recommend that some individuals with AGS avoid consuming dairy products, in particular those whose symptoms are not adequately controlled through meat avoidance alone. […] Many other products and medications may also contain alpha-gal. People with AGS should consult with their health care provider about which foods or other products they should avoid. […] Your doctor will discuss your history of reactions and monitor blood tests to help determine whether alpha-gal-containing foods can be eaten again.

• #8 Alpha-gal and Red Meat Allergy

  https://www.aaaai.org/tools-for-the-public/conditions-library/allergies/alpha-gal-and-red-meat-allergy

  How is an alpha-gal allergy treated? Immediate symptoms such as hives or shortness of breath are treated the same as any other food allergy – in an urgent care setting with epinephrine, anti-histamines and other medications. Prevention long-term involves avoidance of all red meat in sensitized individuals. You may be advised to carry epinephrine, to be used in case of subsequent accidental exposures and reaction. These measures do not necessarily mean switching to a full vegetarian diet, since poultry and fish can be consumed and do not cause similar reactions. As with other food allergies, there is the possibility that over time the sensitivity diminishes although these changes may take many years to become apparent. […] The AAAAI’s Find an Allergist / Immunologist service is a trusted resource to help you find a specialist close to home.

• #9 Alpha-gal syndrome – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/alpha-gal-syndrome/diagnosis-treatment/drc-20428705

  Alpha-gal syndrome treatment involves avoiding the foods that cause your reaction. Always check the ingredient labels on store-bought foods. Make sure they don’t have red meat or meat-based ingredients, such as: […] Be extra careful when you eat at restaurants and social get-togethers. Many people don’t understand how serious an allergic food reaction can be. And few people know that meat allergies exist. Even a small amount of red meat can cause a serious reaction. […] For a serious allergic reaction, you may need a shot of epinephrine and emergency care. Many people with allergies carry a device called an epinephrine auto-injector. It’s a syringe and concealed needle that injects a single dose of medication when you press it against your thigh. If you’ve been diagnosed with alpha-gal syndrome, your doctor or allergist likely will prescribe an epinephrine auto-injector. […] Symptoms of alpha-gal syndrome may lessen or even disappear over time. This is especially true if you don’t get any more bites from ticks that carry alpha-gal. Some people with this condition can eat mammal food products again after 1 to 2 years if they don’t get any more tick bites.

• #10 About Alpha-gal Syndrome | Alpha-gal Syndrome | CDC

  https://www.cdc.gov/alpha-gal-syndrome/about/index.html

  AGS should be managed under the care of an allergist or other healthcare provider. […] Most healthcare providers recommend patients with AGS stop eating meat from mammals, such as beef, pork, lamb, venison, or rabbit. However, not all patients with AGS have reactions to every ingredient containing alpha-gal. […] You will need to work with your healthcare provider to understand which products containing alpha-gal you will need to avoid. […] Prevent tick bites. New tick bites may reactivate allergic reactions to alpha-gal. […] Talk to your healthcare provider before taking a new medication or receiving a vaccine. Although very rare, some people with severe AGS may react to ingredients in certain vaccines or medications.

• #11 Alpha-gal Syndrome (AGS) > Fact Sheets > Yale Medicine

  https://www.yalemedicine.org/conditions/alpha-gal-syndrome-ags

  Treatment involves medications for allergic reactions, avoiding consumption of mammalian meat and foods and medications that contain alpha-gal, avoiding additional tick bites […] While there is no treatment for AGS, people with an allergy can prevent allergic reactions from occurring by avoiding meats and other products that contain alpha-gal. […] While there is no treatment or cure for AGS, treatments are available for the allergic reactions, including anaphylaxis, that people with the condition can experience. […] Treatments for allergic reactions caused by alpha-gal exposure. These treatments include epinephrine (also known as adrenaline), antihistamines, and oral corticosteroids. […] Avoidance of additional tick bites. People in the U.S. who are allergic to alpha-gal should avoid new bites from the lone star tick because they increase the level of IgE antibodies against alpha-gal, thereby increasing sensitivity to alpha-gal.

• #12 Alpha-gal Syndrome: Causes, Diagnosis & Treatment

  https://my.clevelandclinic.org/health/diseases/24493-alpha-gal-syndrome

  Currently, there isnt a cure for AGS. Work with your healthcare provider to find ways to avoid triggers and stay healthy. […] There isnt a cure for alpha-gal syndrome. Early detection can help you and your healthcare provider develop a management plan specific to your needs. […] Treatment for alpha-gal (AGS) syndrome typically involves avoiding foods with alpha-gal and taking medications to manage symptoms that may occur with accidental exposure. Your healthcare provider can work with you to help you avoid products and medications containing alpha-gal. […] Physicians may recommend rescue medications, such as antihistamines or an epinephrine (adrenaline) injector. Other treatments depend on your symptoms. Oral cromolyn solution can help with GI symptoms. […] The outlook for alpha-gal syndrome is good when you follow your treatment plan and avoid triggers.

• #13 Alpha-Gal Allergy: Symptoms, Treatment, Causes, and More

  https://www.healthline.com/health/allergies/alpha-gal

  Allergic reactions to alpha-gal can be treated with an over-the-counter antihistamine such as diphenhydramine (Benadryl). Stronger reactions provoked by alpha-gal might need to be addressed with epinephrine. […] Before taking, always read the ingredient list of any medication; some medications may use animal byproducts in their formulations, such as glycerin or gelatin capsules. To confirm safety, patients with AGS should contact the manufacturer to verify the source of magnesium stearate in their medication. […] If you find out that you have an alpha-gal allergy, get to work identifying your triggers. While all sorts of red meat might need to stay off your table for the time being, there could be other trigger foods that will provoke your symptoms. Dairy products, for example, can contain alpha-gal.

• #14 Diagnosis and treatment of the alpha-Gal syndrome | JAA

  https://www.dovepress.com/current-and-future-strategies-for-the-diagnosis-and-treatment-of-the-a-peer-reviewed-fulltext-article-JAA

  Intramuscular epinephrine administration represents the initial recommendation. […] For tick-bite local reactions, symptomatic treatment with oral antihistamines, corticosteroids and cold compresses should be enough to reduce non-serious symptoms such as pruritus, urticaria and angioedema. […] Mammalian meat desensitization by oral immunotherapy (OIT) has been proposed as a promising treatment for AGS as it would improve patients welfare and safer management. […] Allergen-specific immunotherapy (AIT) using natural and recombinant -Gal containing proteins from tick sialome is also being considered for AGS treatment. […] Given the potential risks associated with immunotherapy, the use of allergen non-specific treatments, such as anti-IgE therapeutic monoclonal antibodies (mAbs), has found application in the treatment of food allergy.

• #15 Alpha-gal Syndrome (AGS) > Fact Sheets > Yale Medicine

  https://www.yalemedicine.org/conditions/alpha-gal-syndrome-ags

  Treatment involves medications for allergic reactions, avoiding consumption of mammalian meat and foods and medications that contain alpha-gal, avoiding additional tick bites […] While there is no treatment for AGS, people with an allergy can prevent allergic reactions from occurring by avoiding meats and other products that contain alpha-gal. […] While there is no treatment or cure for AGS, treatments are available for the allergic reactions, including anaphylaxis, that people with the condition can experience. […] Treatments for allergic reactions caused by alpha-gal exposure. These treatments include epinephrine (also known as adrenaline), antihistamines, and oral corticosteroids. […] Avoidance of additional tick bites. People in the U.S. who are allergic to alpha-gal should avoid new bites from the lone star tick because they increase the level of IgE antibodies against alpha-gal, thereby increasing sensitivity to alpha-gal.

• #16 Alpha-Gal Syndrome Allergen Facts, Symptoms, and Treatment | Allergy Insider

  https://www.thermofisher.com/allergy/us/en/allergen-fact-sheets/alpha-gal-syndrome.html

  Your healthcare provider may recommend a plan that includes the following. Exposure Reduction […] Avoid consumption of red meat and organs. In roughly 80 percent of cases, doing so is sufficient treatment. However, up to 20 percent of individuals also need to avoid dairy and gelatin. Less than 1 percent of people must maintain awareness of the large number of products that are derived from mammals. […] Your healthcare provider may direct you to take one of the following medications to improve your allergy symptoms: Antihistamines for ongoing pruritus (aka itching). Oral corticosteroids to limit swelling with angioedema (i.e., swelling under the skin). […] If you experience a severe allergic reaction, you may need an emergency injection of epinephrine and a visit to the emergency room. Once you’ve been diagnosed with alpha-Gal syndrome, your healthcare provider or allergist likely will prescribe an epinephrine autoinjector.

• #17 Alpha-gal Syndrome: Causes, Diagnosis & Treatment

  https://my.clevelandclinic.org/health/diseases/24493-alpha-gal-syndrome

  Currently, there isnt a cure for AGS. Work with your healthcare provider to find ways to avoid triggers and stay healthy. […] There isnt a cure for alpha-gal syndrome. Early detection can help you and your healthcare provider develop a management plan specific to your needs. […] Treatment for alpha-gal (AGS) syndrome typically involves avoiding foods with alpha-gal and taking medications to manage symptoms that may occur with accidental exposure. Your healthcare provider can work with you to help you avoid products and medications containing alpha-gal. […] Physicians may recommend rescue medications, such as antihistamines or an epinephrine (adrenaline) injector. Other treatments depend on your symptoms. Oral cromolyn solution can help with GI symptoms. […] The outlook for alpha-gal syndrome is good when you follow your treatment plan and avoid triggers.

• #18 Alpha-gal syndrome: Recognizing and managing a tick-bite–related meat allergy | Cleveland Clinic Journal of Medicine

  https://www.ccjm.org/content/92/5/311

  An oral cromolyn solution may also be prescribed to stabilize mast cells, particularly to address gastrointestinal symptoms. […] Moreover, for refractory cases, the anti-IgE monoclonal antibody omalizumab may be helpful. […] Referral to an allergist should be placed when patients have symptoms such as facial or throat swelling, voice changes, breathing difficulties, hives, or fainting after eating. […] These symptoms suggest a high risk of anaphylaxis and the need for epinephrine autoinjectors.

• #19 Alpha-gal syndrome – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/alpha-gal-syndrome/diagnosis-treatment/drc-20428705

  Alpha-gal syndrome treatment involves avoiding the foods that cause your reaction. Always check the ingredient labels on store-bought foods. Make sure they don’t have red meat or meat-based ingredients, such as: […] Be extra careful when you eat at restaurants and social get-togethers. Many people don’t understand how serious an allergic food reaction can be. And few people know that meat allergies exist. Even a small amount of red meat can cause a serious reaction. […] For a serious allergic reaction, you may need a shot of epinephrine and emergency care. Many people with allergies carry a device called an epinephrine auto-injector. It’s a syringe and concealed needle that injects a single dose of medication when you press it against your thigh. If you’ve been diagnosed with alpha-gal syndrome, your doctor or allergist likely will prescribe an epinephrine auto-injector. […] Symptoms of alpha-gal syndrome may lessen or even disappear over time. This is especially true if you don’t get any more bites from ticks that carry alpha-gal. Some people with this condition can eat mammal food products again after 1 to 2 years if they don’t get any more tick bites.

• #20 Alpha-gal syndrome – Symptoms and causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/alpha-gal-syndrome/symptoms-causes/syc-20428608

  There’s no treatment other than avoiding red meat and other products made from mammals. […] If you have a serious allergic reaction, you may need medicine called epinephrine and treatment at the emergency room. […] Anaphylaxis is treated with prescription medicine called epinephrine, also known as adrenaline. You can give yourself a shot of epinephrine with a device called an auto-injector (EpiPen, Auvi-Q, others). You also need to go to the emergency room.

• #21 Management of Alpha-gal Syndrome – Alpha-gal Information

  https://alphagalinformation.org/management-of-ags/

  Currently, there is no cure or treatment for alpha-gal syndrome. […] People with AGS need to avoid foods and other products that contain alpha-gal in order to prevent allergic reactions. […] Yes, the symptoms of AGS can be managed, as with any other allergy. […] Your doctor can advise you about medications and strategies for managing your symptoms. […] Your doctor may recommend antihistamines, steroids, or other medications. […] Most, or possibly all, people with AGS need an epinephrine autoinjector, like an epipen. […] If your doctor gives you an epinephrine autoinjector, it is very important that you learn how to use it, follow the directions your doctor gives you, and ask your doctor for a rescue plan.

• #22 Alpha-Gal Syndrome and Meat Allergy – Allergy & Asthma Network

  https://allergyasthmanetwork.org/food-allergies/alpha-gal-syndrome-and-meat-allergy/

  Alpha-gal allergy treatment […] People with AGS should always carry epinephrine in case of a severe or life-threatening allergic reaction, also called anaphylaxis. Epinephrine should be given first and fast to treat anaphylaxis. It’s important to carry two doses of epinephrine in case symptoms worsen or return. […] Like other food allergies, avoidance of the trigger food is the key to preventing symptoms. It is critical for people with AGS to avoid eating red meat and any other meat products that contain the alpha-gal sugar molecule. […] […] […] Is there a cure for alpha-gal syndrome? […] There is no cure for alpha-gal syndrome. If you’re diagnosed with AGS, the best way to avoid an allergic reaction is to not eat red meat. People with AGS who accidentally eat red meat should carry an epinephrine auto-injector, the best treatment for severe allergic reactions. The good news is that AGS is not a lifelong condition. […] […] […] Are there meat allergy home remedies? […] No, there are no home remedies for AGS. The best action to prevent a meat allergy is to avoid tick bites. If you already have the condition, then avoid eating any meat products containing alpha gal.

• #23 Alpha-Gal Syndrome – What You Need to Know

  https://www.drugs.com/cg/alpha-gal-syndrome.html

  AGS cannot be cured, but symptoms may get less severe or stop. This can take 8 months to 5 years. Until then, you will need to avoid being exposed to anything that triggers a reaction. You may need to see specialists, such as an allergist or dietitian, for ongoing care. The following medicines may be needed to manage allergic reactions: […] Antihistamines decrease mild symptoms such as itching or a rash. […] Steroids help reduce swelling. […] Epinephrine is used to treat severe allergic reactions such as anaphylaxis. Anaphylaxis symptoms include throat tightness, trouble breathing, tingling, dizziness, and wheezing. You will be taught how to use epinephrine if you are at risk for anaphylaxis.

• #24 Alpha-gal Syndrome (AGS) > Fact Sheets > Yale Medicine

  https://www.yalemedicine.org/conditions/alpha-gal-syndrome-ags

  Treatment involves medications for allergic reactions, avoiding consumption of mammalian meat and foods and medications that contain alpha-gal, avoiding additional tick bites […] While there is no treatment for AGS, people with an allergy can prevent allergic reactions from occurring by avoiding meats and other products that contain alpha-gal. […] While there is no treatment or cure for AGS, treatments are available for the allergic reactions, including anaphylaxis, that people with the condition can experience. […] Treatments for allergic reactions caused by alpha-gal exposure. These treatments include epinephrine (also known as adrenaline), antihistamines, and oral corticosteroids. […] Avoidance of additional tick bites. People in the U.S. who are allergic to alpha-gal should avoid new bites from the lone star tick because they increase the level of IgE antibodies against alpha-gal, thereby increasing sensitivity to alpha-gal.

• #25 Allergists say alpha-gal red meat allergy better understood, as numbers continue to increase – VUMC News

  https://news.vumc.org/2016/12/21/allergists-say-alpha-gal-red-meat-allergy-better-understood-as-numbers-continue-to-increase/

  We arent sure if the patients get better or develop a tolerance of more mammalian product consumption on diet alone, but I do see that after two years of diet many are able to tolerate some level of mammalian product consumption, Stone said. […] Many patients have elected to pursue an alpha gal-reduced diet by eating only a little red meat and hoping it is below the threshold at which they have an allergic reaction, or using antihistamines to increase that threshold to see how reactive they are, Stone said. […] There are several alpha-gal patients who did not show improvement on a restrictive diet and those were the ones who were again exposed to alpha-gal by tick bite. […] For now, tick bite prevention is the only sure way to avoid alpha-gal red meat allergy.

• #26 Alpha-Gal Allergy: Symptoms, Treatment, Causes, and More

  https://www.healthline.com/health/allergies/alpha-gal

  People with any serious food allergy should be hyperaware of whats in their food. If your symptoms are serious when you have an allergic reaction, you might want to start carrying a portable epinephrine treatment (such as an EpiPen) in case of an emergency. Make sure that your family, co-workers, and people you live with know what to do if you have a severe allergic reaction. Go over possible action plans with them before you need their help. […] Make yourself harder for ticks to target by using insect repellant when exploring wooded areas. Wear long sleeves and long pants whenever possible if youre in the woods. Check your hair, scalp, arms, and ears frequently for ticks that may be trying to latch on to your skin. Know the proper way to remove and dispose of a tick if you do get bitten.

• #27 Alpha-Gal Allergy: Causes, Symptoms And Treatment

  https://familymedicineaustin.com/alpha-gal-allergy-treatment/

  Alpha-Gal Allergy Treatment and Prevention […] Ticks can be a nuisance theyre tiny and can hide in human skin and hair. You should try your best to prevent tick bites. […] You can avoid AGS symptoms by maintaining a diet with minimum consumption of: […] In 2020, the FDA approved the genetic modification of pigs so that alpha-gal is absent from their products. If you suffer from AGS and enjoy pork, you may safely consume pork that is developed under the GalSafe trademark. […] Since allergic reactions usually trigger the release of histamine locally or generally in the body, an antihistamine is the most effective alpha-gal allergy treatment. Antihistamine medication is readily available over the counter, such as Benadryl (diphenhydramine). An intense reaction like anaphylaxis must be treated with epinephrine. Your allergist will most likely prescribe an EpiPen for this purpose. […] A small study in 2020 suggested that Omalizumab may help AGS symptoms. According to the findings, 86% of patients in the study reported an improvement in symptoms after being exposed to mammalian food products by accident or on purpose. You may discuss the use of Omalizumab with your doctor if you have AGS. […] AGS is an acquired allergy from a tick bite that causes adverse bodily reactions when eating red meat. A delayed response occurs after three to six hours of eating mammalian products. You should document any symptoms you have to explain to your doctor so they can provide the best diagnosis and alpha-gal allergy treatment. With your doctor, you can discuss the lifestyle changes and medication you will need to prevent a dangerous and possibly fatal reaction.

• #28 Alpha-Gal Syndrome Meat Allergy: Symptoms, Causes & What to Do When Bitten – St. Louis Allergy Relief

  https://stlouisallergyrelief.com/alpha-gal-syndrome-meat-allergy-symptoms-causes-what-to-do-when-bitten/

  The primary strategy for managing AGS involves strict avoidance of red meat and products derived from mammals. Although very rare, some people with severe AGS may react to ingredients in certain vaccines or medications. This dietary adjustment is crucial to preventing allergic reactions and minimizing the impact of AGS on an individual’s quality of life. On the bright side, enjoying other kinds of meats like poultry, fish, and shellfish won’t lead to symptoms of Alpha-Gal Syndrome. Eggs, fruits, and vegetables are also safe to eat! […] Preventing tick bites is paramount in reducing the risk of AGS. Individuals in regions with lone star tick prevalence should adopt measures such as using insect repellent, wearing protective clothing, and conducting thorough tick checks after outdoor activities. Steer clear of grassy, brushy, and wooded areas where ticks may lurk, and stick to the center of trails while walking. For the best defense against tick bites, go for repellents with at least 20% of active stuff like DEET, picaridin, or IR3535. However, it’s worth noting that using DEET products with concentrations exceeding 50% won’t necessarily provide added defense against tick bites. Stick to the recommended range for optimal results.

• #29 Alpha-gal syndrome – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/alpha-gal-syndrome/diagnosis-treatment/drc-20428705

  Alpha-gal syndrome treatment involves avoiding the foods that cause your reaction. Always check the ingredient labels on store-bought foods. Make sure they don’t have red meat or meat-based ingredients, such as: […] Be extra careful when you eat at restaurants and social get-togethers. Many people don’t understand how serious an allergic food reaction can be. And few people know that meat allergies exist. Even a small amount of red meat can cause a serious reaction. […] For a serious allergic reaction, you may need a shot of epinephrine and emergency care. Many people with allergies carry a device called an epinephrine auto-injector. It’s a syringe and concealed needle that injects a single dose of medication when you press it against your thigh. If you’ve been diagnosed with alpha-gal syndrome, your doctor or allergist likely will prescribe an epinephrine auto-injector. […] Symptoms of alpha-gal syndrome may lessen or even disappear over time. This is especially true if you don’t get any more bites from ticks that carry alpha-gal. Some people with this condition can eat mammal food products again after 1 to 2 years if they don’t get any more tick bites.

• #30 Alpha-gal syndrome – Wikipedia

  https://en.wikipedia.org/wiki/Alpha-gal_syndrome

  In addition to avoiding triggers, such as mammalian meat, treatment is aimed at alleviating symptoms and is highly dependent on severity. If an allergic individual who only experiences relatively mild symptoms consumes food containing alpha-gal, then treatment with over-the-counter antihistamines may be acceptable. In cases where more severe reactions like anaphylaxis are observed, admission to a hospital for emergency treatment is necessary. In these situations, treatment is the same as for any anaphylactic reaction, and necessitates epinephrine administration. […] As of 2017, only two successful desensitizations have been performed on patients with an alpha-gal allergy. […] There is no cure for alpha-gal; the main form of management is abstaining from mammalian meat, including lamb, beef, pork, and other mammalian products if necessary. These products have been found to have the highest risk of reaction, whereas dairy products present a much lower risk. Avoidance of dairy is not generally recommended as most afflicted individuals do not have reactions to dairy consumption. Unlike most food allergies, in some people, the alpha-gal allergy may recede over time as long as another tick does not bite the person. It has been found that with avoidance of further tick bites, levels of serum IgE decline. The recovery period can take 8 months to 5 years.

• #31 Life with Alpha-Gal Red Meat Allergy | Entomology

  https://entomology.ca.uky.edu/ef656

  There is no known treatment for alpha-gal syndrome. Instead, lifestyle changes can be made that help manage and reduce the symptoms. People who have alpha gal must remove beef, pork, and lamb from their diets to avoid allergic reactions. […] The symptoms of alpha-gal may decrease over time, particularly if further bites from lone star ticks are prevented. In some cases this has taken 1-2 years. More bites from ticks carrying alpha-gal though could extend the window of symptoms. […] Individuals should work with a health care provider, such as a registered dietitian, to find a diet that works for them and meets their personal nutrition needs.

• #32 Diagnosis and management of patients with the α-Gal syndrome

  https://pmc.ncbi.nlm.nih.gov/articles/PMC6980324/

  The -Gal syndrome has many novel features that are relevant to diagnosis and management. In general, the diagnosis also dictates the primary treatment, i.e. avoiding mammalian meat and also dairy in some cases. […] Blood levels of IgE to -Gal often drop in patients who avoid recurrent tick bites, but the rate of decline is variable. Similarly, the delay before reactions is variable and the severity of the allergic reactions is not predicted by the delay or the titer of specific IgE. […] The primary advice for newly diagnosed cases of the syndrome is to completely avoid meat of mammals. […] Avoiding products such as milk, yogurt, and ice cream is relatively easy because there are alternatives made from almond, oat, cashew or other non-mammalian sources. […] The argument about a dairy-free diet changes completely if consumption of -Gal containing products can contribute to inflammation without giving rise to allergic symptoms.

• #33 Alpha-gal syndrome – Wikipedia

  https://en.wikipedia.org/wiki/Alpha-gal_syndrome

  In addition to avoiding triggers, such as mammalian meat, treatment is aimed at alleviating symptoms and is highly dependent on severity. If an allergic individual who only experiences relatively mild symptoms consumes food containing alpha-gal, then treatment with over-the-counter antihistamines may be acceptable. In cases where more severe reactions like anaphylaxis are observed, admission to a hospital for emergency treatment is necessary. In these situations, treatment is the same as for any anaphylactic reaction, and necessitates epinephrine administration. […] As of 2017, only two successful desensitizations have been performed on patients with an alpha-gal allergy. […] There is no cure for alpha-gal; the main form of management is abstaining from mammalian meat, including lamb, beef, pork, and other mammalian products if necessary. These products have been found to have the highest risk of reaction, whereas dairy products present a much lower risk. Avoidance of dairy is not generally recommended as most afflicted individuals do not have reactions to dairy consumption. Unlike most food allergies, in some people, the alpha-gal allergy may recede over time as long as another tick does not bite the person. It has been found that with avoidance of further tick bites, levels of serum IgE decline. The recovery period can take 8 months to 5 years.

• #34 10 New and Surprising Facts About Alpha-Gal Syndrome | Allergy Insider

  https://www.thermofisher.com/allergy/us/en/living-with-allergies/food-allergies/10-new-and-surprising-facts-about-alpha-gal-syndrome.html

  Blood testing is paramount in testing for alpha-Gal; skin-prick tests (SPTs) aren’t effective. Given the time and money that can be involved in securing a diagnosis, testing for alpha-Gal syndrome is critical. There is no explicit AGS treatment, so its vital to receive a proper diagnosis to know what products and foods to avoid. […] Yes. You can ask your healthcare provider for an alpha-Gal allergy blood test. But instead of a whole allergen blood test, which helps providers rule allergies in or out, an allergen component test for alpha-Gal allergy may help to pinpoint the specific sugar molecule that is causing symptoms. Plus, allergen component testing may offer providers insight into the severity of an individuals reactions. […] Thankfully, according to information from the Mayo Clinic, symptoms may lessen or even disappear over time if sensitized individuals dont receive additional bites from ticks carrying alpha-Gal.

• #35 Diagnosis and treatment of the alpha-Gal syndrome | JAA

  https://www.dovepress.com/current-and-future-strategies-for-the-diagnosis-and-treatment-of-the-a-peer-reviewed-fulltext-article-JAA

  The AGS is an allergic disorder that challenges clinical diagnosis due to inapparent presentation and delayed reactions. […] Daily diet counseling, tick bite avoidance or environmental education should be firstly considered in customizing an accurate treatment for the AGS. […] The prevention of tick bites is relevant because continuous exposure to tick bites may maintain or increase anti–Gal IgE titers and lead to allergic responses to previously tolerated foods. […] Avoidance of mammalian meat, by-products of meat (innards), fat (gelatin and lards) and other -Gal-containing foods such as dairy products represent a crucial management strategy for AGS. […] Another major foundation for AGS management is education. […] Due to the AGS delay and unexpected symptomatology, emergency treatment is of utmost importance to correctly manage allergic reactions and potentially life-threatening anaphylaxis.

• #36 Alpha gal Symptoms, Testing & Treatment Explained – Amy Burkhart, MD, RD

  https://theceliacmd.com/is-your-ibs-due-to-alpha-gal-syndrome/

  An epi-pen should be prescribed to anyone diagnosed with AGS. […] Treatment involves educating the patient on avoiding meat and products containing ingredients derived from mammals. This includes medications and supplements which are commonly made in gelatin-derived capsules. […] Avoiding products that contain alpha-gal is essential. Unlike most allergies, the reaction to alpha-gal tends to decrease with time. However, if additional tick bites occur, the immune response can increase and become more severe. […] All people with alpha-gal allergy should be followed by an allergist and be checked routinely for blood levels and ongoing symptoms. […] Factors such as alcohol, exercise, menstruation, and NSAIDS can worsen the reaction. Cooking does not destroy the alpha-gal molecule in meat. Collagen and gelatin must be avoided.

• #37 ALPHA-GAL SYNDROME: A TICK-TRANSMITTED RED MEAT ALLERGY EVERYONE SHOULD KNOW ABOUT | Mya Care

  https://myacare.com/blog/alphagal-syndrome-a-ticktransmitted-red-meat-allergy-everyone-should-know-about

  An ideal diet for alpha-gal syndrome depends on the persons sensitivity and requires some investigation to pinpoint their unique triggers. The first recommendation is to cut out all red meat from the diet, especially porcine and organ meats. Some patients may be able to tolerate dairy, while others cannot. Fatty dairy, such as ice-cream, may be especially problematic. If symptoms still persist, all dairy can be cut out, and other sources of alpha-gal need to be weeded out of the diet, such as gelatin and carrageenan. Additionally, a healthy diet high in nutrients and fiber may be helpful for lowering immune reactivity. […] It is vital to check all ingredients in any medications or supplements you are taking to ensure they do not contain animal products like gelatin. This includes the inactive ingredients, which are readily overlooked, such as magnesium stearate. […] Symptoms may intensify after exercise, during infection, or while menstruating. Certain foods may only become triggers in the presence of these factors. A person with alpha-gal syndrome should not avoid exercising but should rather avoid triggers that do not allow them to exercise safely.

• #38 Alpha-Gal Allergy: Symptoms, Treatment, Causes, and More

  https://www.healthline.com/health/allergies/alpha-gal

  Allergic reactions to alpha-gal can be treated with an over-the-counter antihistamine such as diphenhydramine (Benadryl). Stronger reactions provoked by alpha-gal might need to be addressed with epinephrine. […] Before taking, always read the ingredient list of any medication; some medications may use animal byproducts in their formulations, such as glycerin or gelatin capsules. To confirm safety, patients with AGS should contact the manufacturer to verify the source of magnesium stearate in their medication. […] If you find out that you have an alpha-gal allergy, get to work identifying your triggers. While all sorts of red meat might need to stay off your table for the time being, there could be other trigger foods that will provoke your symptoms. Dairy products, for example, can contain alpha-gal.

• #39

  https://link.springer.com/article/10.1007/s40521-023-00353-6

  Alpha-gal (-gal) syndrome (AGS) represents a paradigm shift in food allergy since the allergen (-gal), unlike most protein allergens, is an oligosaccharide found in mammalian meat and because of the delayed onset of allergic symptoms (3 to 6 h after consumption). […] Treatment is based on avoiding mammalian meat consumption and in some cases also mammalian-derived products. […] In recent years, a few studies of oral desensitization against -gal have been published with promising results. […] Future treatment strategies may involve combining anti-IgE therapy with oral desensitization to improve management outcomes. […] This report described the first successful desensitization protocol to red meat in adults with alpha-gal syndrome. […] This is the most recent study on the success of alpha-gal oral immunotherapy in a group of patients with alpha-gal syndrome.

• #40 Diagnosis and treatment of the alpha-Gal syndrome | JAA

  https://www.dovepress.com/current-and-future-strategies-for-the-diagnosis-and-treatment-of-the-a-peer-reviewed-fulltext-article-JAA

  Intramuscular epinephrine administration represents the initial recommendation. […] For tick-bite local reactions, symptomatic treatment with oral antihistamines, corticosteroids and cold compresses should be enough to reduce non-serious symptoms such as pruritus, urticaria and angioedema. […] Mammalian meat desensitization by oral immunotherapy (OIT) has been proposed as a promising treatment for AGS as it would improve patients welfare and safer management. […] Allergen-specific immunotherapy (AIT) using natural and recombinant -Gal containing proteins from tick sialome is also being considered for AGS treatment. […] Given the potential risks associated with immunotherapy, the use of allergen non-specific treatments, such as anti-IgE therapeutic monoclonal antibodies (mAbs), has found application in the treatment of food allergy.

• #41 The Alpha-Gal Syndrome: Unique Tick-Borne Illness on the Rise – Clinical Advisor

  https://www.clinicaladvisor.com/features/alpha-gal-syndrome-tick-borne-illness/

  Avoidance of mammalian meat, by-products of meat, fat, and other alpha-gal containing foods such as dairy products is also a critical treatment strategy for AGS. Patients should receive nutrition counseling regarding which foods can trigger allergy. They also need to understand how to attain sufficient calcium, iron, and vitamin B12 in their diet after excluding these foods. […] Symptomatic treatment of an allergy includes antihistamines, corticosteroids, cromolyn-based mast cell stabilizers, antiemetics, and antidiarrheal agents. These are pharmacologic agents that can be prescribed by the health care provider. […] Mammalian meat desensitization by oral immunotherapy (OIT) has been proposed as a promising treatment for AGS. It consists of daily intake of very small and incrementally increasing amounts of allergen in order to reduce the immune response and consequently produce allergen desensitization. However, this procedure has not been sufficiently researched for safe use at this time.

• #42

  https://link.springer.com/article/10.1007/s40521-023-00353-6

  Alpha-gal (-gal) syndrome (AGS) represents a paradigm shift in food allergy since the allergen (-gal), unlike most protein allergens, is an oligosaccharide found in mammalian meat and because of the delayed onset of allergic symptoms (3 to 6 h after consumption). […] Treatment is based on avoiding mammalian meat consumption and in some cases also mammalian-derived products. […] In recent years, a few studies of oral desensitization against -gal have been published with promising results. […] Future treatment strategies may involve combining anti-IgE therapy with oral desensitization to improve management outcomes. […] This report described the first successful desensitization protocol to red meat in adults with alpha-gal syndrome. […] This is the most recent study on the success of alpha-gal oral immunotherapy in a group of patients with alpha-gal syndrome.

• #43 American Academy of Allergy, Asthma & Immunology Annual Meeting

  https://www.healio.com/news/primary-care/20200318/omalizumab-may-help-treat-red-meat-allergy-caused-by-tick-bites

  Omalizumab may effectively treat food allergy symptoms in patients with alpha-gal syndrome, according to research from a small study that was to be presented at the American Academy of Asthma, Allergy Immunology Annual Meeting. […] Based on these early findings, omalizumab may be an effective management and, perhaps, treatment for alpha-gal food allergy, he told Healio Primary Care. […] Commins said that more research is needed to determine if omalizumab is effective in all patients with alpha-gal allergies, and to assess the long-term impact of omalizumab on these and other food allergies.

• #44 Diagnosis and treatment of the alpha-Gal syndrome | JAA

  https://www.dovepress.com/current-and-future-strategies-for-the-diagnosis-and-treatment-of-the-a-peer-reviewed-fulltext-article-JAA

  Intramuscular epinephrine administration represents the initial recommendation. […] For tick-bite local reactions, symptomatic treatment with oral antihistamines, corticosteroids and cold compresses should be enough to reduce non-serious symptoms such as pruritus, urticaria and angioedema. […] Mammalian meat desensitization by oral immunotherapy (OIT) has been proposed as a promising treatment for AGS as it would improve patients welfare and safer management. […] Allergen-specific immunotherapy (AIT) using natural and recombinant -Gal containing proteins from tick sialome is also being considered for AGS treatment. […] Given the potential risks associated with immunotherapy, the use of allergen non-specific treatments, such as anti-IgE therapeutic monoclonal antibodies (mAbs), has found application in the treatment of food allergy.

• #45 The Alpha-Gal Syndrome: Unique Tick-Borne Illness on the Rise – Clinical Advisor

  https://www.clinicaladvisor.com/features/alpha-gal-syndrome-tick-borne-illness/

  The use of anti-IgE therapy has been researched in the treatment of food allergy. In anti-IgE therapy, monoclonal antibodies (mAbs) are administered that bind to IgE and IgE-coated B-cells to reduce the reaction of antibodies with mast cells and basophils. The combination of anti-IgE therapy as a pre-treatment for OIT has also been researched. The anti-IgE monoclonal antibody omalizumab has been used in specialized centers as monotherapy in AGS patients for successfully controlling continued reactivity, allowing the introduction of a small amount of mammalian meat into the diet.

• #46

  https://link.springer.com/article/10.1007/s40521-023-00353-6

  Alpha-gal (-gal) syndrome (AGS) represents a paradigm shift in food allergy since the allergen (-gal), unlike most protein allergens, is an oligosaccharide found in mammalian meat and because of the delayed onset of allergic symptoms (3 to 6 h after consumption). […] Treatment is based on avoiding mammalian meat consumption and in some cases also mammalian-derived products. […] In recent years, a few studies of oral desensitization against -gal have been published with promising results. […] Future treatment strategies may involve combining anti-IgE therapy with oral desensitization to improve management outcomes. […] This report described the first successful desensitization protocol to red meat in adults with alpha-gal syndrome. […] This is the most recent study on the success of alpha-gal oral immunotherapy in a group of patients with alpha-gal syndrome.

• #47 American Academy of Allergy, Asthma & Immunology Annual Meeting

  https://www.healio.com/news/primary-care/20200318/omalizumab-may-help-treat-red-meat-allergy-caused-by-tick-bites

  Omalizumab may effectively treat food allergy symptoms in patients with alpha-gal syndrome, according to research from a small study that was to be presented at the American Academy of Asthma, Allergy Immunology Annual Meeting. […] Based on these early findings, omalizumab may be an effective management and, perhaps, treatment for alpha-gal food allergy, he told Healio Primary Care. […] Commins said that more research is needed to determine if omalizumab is effective in all patients with alpha-gal allergies, and to assess the long-term impact of omalizumab on these and other food allergies.

• #48 Tick-borne red meat allergy prevented in mice through new nanoparticle treatment – Chemical Engineering

  https://che.engin.umich.edu/2024/08/12/tick-borne-red-meat-allergy-prevented-in-mice-through-new-nanoparticle-treatment/

  Nanoparticles delivered intravenously in mice can block the allergic reactions to red meat caused by the bite of the lone star tick, new research led by the University of Michigan shows. […] Developed at U-M, the nanoparticles contain allergens that retrain the immune system to ignore the type of sugar found in beef, pork, lamb and other mammals. […] „Treating food allergies usually means de-sensitizing patients to the allergen so that their immune system does not react inappropriately,” said Lonnie Shea, the Steven A. Goldstein Collegiate Professor of Biomedical Engineering and Professor of Chemical Engineering at U-M and co-corresponding author on the study. „Our nanoparticles, when introduced prior to or after sensitization, have been remarkably effective in reducing the immune response in multiple food allergies.”

• #49 Tick-borne red meat allergy prevented in mice through new nanoparticle treatment – Chemical Engineering

  https://che-dev-01.engin.umich.edu/2024/08/12/tick-borne-red-meat-allergy-prevented-in-mice-through-new-nanoparticle-treatment/

  Nanoparticles delivered intravenously in mice can block the allergic reactions to red meat caused by the bite of the lone star tick, new research led by the University of Michigan shows. […] Developed at U-M, the nanoparticles contain allergens that retrain the immune system to ignore the type of sugar found in beef, pork, lamb and other mammals. […] Treating food allergies usually means de-sensitizing patients to the allergen so that their immune system does not react inappropriately, said Lonnie Shea, the Steven A. Goldstein Collegiate Professor of Biomedical Engineering and Professor of Chemical Engineering at U-M and co-corresponding author on the study. Our nanoparticles, when introduced prior to or after sensitization, have been remarkably effective in reducing the immune response in multiple food allergies.

• #50 Tick-borne red meat allergy prevented in mice through new nanoparticle treatment – Chemical Engineering

  https://che.engin.umich.edu/2024/08/12/tick-borne-red-meat-allergy-prevented-in-mice-through-new-nanoparticle-treatment/

  Nanoparticles delivered intravenously in mice can block the allergic reactions to red meat caused by the bite of the lone star tick, new research led by the University of Michigan shows. […] Developed at U-M, the nanoparticles contain allergens that retrain the immune system to ignore the type of sugar found in beef, pork, lamb and other mammals. […] „Treating food allergies usually means de-sensitizing patients to the allergen so that their immune system does not react inappropriately,” said Lonnie Shea, the Steven A. Goldstein Collegiate Professor of Biomedical Engineering and Professor of Chemical Engineering at U-M and co-corresponding author on the study. „Our nanoparticles, when introduced prior to or after sensitization, have been remarkably effective in reducing the immune response in multiple food allergies.”

• #51 Tick-borne red meat allergy prevented in mice through new nanoparticle treatment – Chemical Engineering

  https://che.engin.umich.edu/2024/08/12/tick-borne-red-meat-allergy-prevented-in-mice-through-new-nanoparticle-treatment/

  „While these findings highlight the first therapeutic potential of nanoparticles to treat red meat allergy, we’re calling for further studies to better understand the implications and the long-lasting effects of nanoparticle treatment.” […] „Our goal with the allergen-encapsulating nanoparticles is to retrain the immune system to be tolerant to the allergen with a small number of doses, with the ultimate goal of achieving long-lived tolerance.”

• #52 Tick-borne red meat allergy prevented in mice through new nanoparticle treatment – Chemical Engineering

  https://che.engin.umich.edu/2024/08/12/tick-borne-red-meat-allergy-prevented-in-mice-through-new-nanoparticle-treatment/

  „While these findings highlight the first therapeutic potential of nanoparticles to treat red meat allergy, we’re calling for further studies to better understand the implications and the long-lasting effects of nanoparticle treatment.” […] „Our goal with the allergen-encapsulating nanoparticles is to retrain the immune system to be tolerant to the allergen with a small number of doses, with the ultimate goal of achieving long-lived tolerance.”

• #53 Successful Treatment for Alpha Gal Mammal Product Allergy Using Auricular Acupuncture: A Case Series

  https://pmc.ncbi.nlm.nih.gov/articles/PMC8729907/

  Alpha gal syndrome (AGS) is an acquired allergy to mammalian products correlates with a tick bite(s) that appears to cause immune sensitization to an oligosaccharide in meat. […] The objective of this study is to describe 2 populations of subjects who underwent Soliman Auricular Allergy Treatment (SAAT) for significant AGS meat and/or dairy allergy. […] The SAAT method showed effectiveness in the large majority of patients. No adverse reactions were noted as a result of auricular acupuncture. This alternative medicine approach to AGS management should be further studied in prospective trials with laboratory confirmation both before and after the procedure. This low-risk treatment shows promise in treating a medical condition that causes distress in an increasing number of patients. […] All patients received treatment for AGS using the SAAT method. For those individuals with available outcome data on SAAT effectiveness (n=126), 121 (96%) patients indicated that their symptoms were in remission after SAAT.

• #54 Successful Treatment for Alpha Gal Mammal Product Allergy Using Auricular Acupuncture: A Case Series

  https://pmc.ncbi.nlm.nih.gov/articles/PMC8729907/

  Alpha gal syndrome (AGS) is an acquired allergy to mammalian products correlates with a tick bite(s) that appears to cause immune sensitization to an oligosaccharide in meat. […] The objective of this study is to describe 2 populations of subjects who underwent Soliman Auricular Allergy Treatment (SAAT) for significant AGS meat and/or dairy allergy. […] The SAAT method showed effectiveness in the large majority of patients. No adverse reactions were noted as a result of auricular acupuncture. This alternative medicine approach to AGS management should be further studied in prospective trials with laboratory confirmation both before and after the procedure. This low-risk treatment shows promise in treating a medical condition that causes distress in an increasing number of patients. […] All patients received treatment for AGS using the SAAT method. For those individuals with available outcome data on SAAT effectiveness (n=126), 121 (96%) patients indicated that their symptoms were in remission after SAAT.

• #55 SAAT Treatment for Alpha-Gal: How Does it Work? – Healing Points Acupuncture & Wellness Center

  https://healingpoints-acu.com/alpha-gal-saat-treatment/?srsltid=AfmBOop_zB3Pl7aG1LmlpiBkzF0pUAhehp0oqMiN4ZhrCqg7N24zRnnR

  Alpha-gal SAAT treatment is a simple and effective method of helping to recede the symptoms of alpha-gal syndrome or red meat allergy with a particular type of auricular (ear) acupuncture. […] Soliman Auricular Allergy Treatment, or SAAT, is a proven acupuncture practice that helps relieve those suffering from an alpha-gal allergy. […] Typically, one to three treatments are needed, and the treatment is simple, economical, and has no known side effects. […] This auricular (ear) acupuncture treatment is basically painless and is medically accepted by the World Health Organization. […] SAAT treatment has been effective for the large majority of patients and showed no adverse reactions, according to a study published in a Medical Acupuncture Journal.

• #56 Successful Treatment for Alpha Gal Mammal Product Allergy Using Auricular Acupuncture: A Case Series

  https://pmc.ncbi.nlm.nih.gov/articles/PMC8729907/

  Based on this study, the SAAT approach is safe and effective to treat AGS. Owing to absence of direct exposure to the actual allergen, patients have no risk of severe allergic reaction or anaphylaxis (in contrast to allergy shots). […] Ninety-six percent of patients with available outcome data had complete remission of AGS mammalian product allergy after SAAT treatment lasting months to years. No adverse reactions were noted as a result of the auricular acupuncture. This alternative medicine approach to AGS management should be further studied in prospective trials with firm laboratory confirmation both before and after the procedure. This low-risk treatment shows promise in treating a medical condition that causes distress in an increasing number of patients.

• #57 SAAT Treatment for Alpha-Gal: How Does it Work? – Healing Points Acupuncture & Wellness Center

  https://healingpoints-acu.com/alpha-gal-saat-treatment/?srsltid=AfmBOop_zB3Pl7aG1LmlpiBkzF0pUAhehp0oqMiN4ZhrCqg7N24zRnnR

  Alpha-gal SAAT treatment is a simple and effective method of helping to recede the symptoms of alpha-gal syndrome or red meat allergy with a particular type of auricular (ear) acupuncture. […] Soliman Auricular Allergy Treatment, or SAAT, is a proven acupuncture practice that helps relieve those suffering from an alpha-gal allergy. […] Typically, one to three treatments are needed, and the treatment is simple, economical, and has no known side effects. […] This auricular (ear) acupuncture treatment is basically painless and is medically accepted by the World Health Organization. […] SAAT treatment has been effective for the large majority of patients and showed no adverse reactions, according to a study published in a Medical Acupuncture Journal.

• #58 Diagnosis and management of patients with the α-Gal syndrome

  https://pmc.ncbi.nlm.nih.gov/articles/PMC6980324/

  It is important to remember that random cohorts of subjects in TN, VA, and NC have found that 15% or more of the population have IgE to -Gal. Thus, there must be many subjects who do not experience allergic symptoms despite having the sensitization. […] The risk and also severity of reactions in the -Gal syndrome relates to the amount of the oligosaccharide that is present in food, drugs or other therapeutics. […] There are hundreds of ways in which food and other products which are not obviously mammalian could nonetheless have products from mammals added during preparation or manufacture. […] We are aware that there are some alternative/complementary medical approaches being offered in the community for the treatment of the -Gal syndrome, e.g. auricular acupuncture, kinesiology and others. An interesting possibility is that the apparent efficacy observed in some of these cases actually reflects the natural history of the syndrome, i.e.- -Gal sIgE levels can drop rapidly in some cases.

• #59 Successful Treatment for Alpha Gal Mammal Product Allergy Using Auricular Acupuncture: A Case Series

  https://pmc.ncbi.nlm.nih.gov/articles/PMC8729907/

  Based on this study, the SAAT approach is safe and effective to treat AGS. Owing to absence of direct exposure to the actual allergen, patients have no risk of severe allergic reaction or anaphylaxis (in contrast to allergy shots). […] Ninety-six percent of patients with available outcome data had complete remission of AGS mammalian product allergy after SAAT treatment lasting months to years. No adverse reactions were noted as a result of the auricular acupuncture. This alternative medicine approach to AGS management should be further studied in prospective trials with firm laboratory confirmation both before and after the procedure. This low-risk treatment shows promise in treating a medical condition that causes distress in an increasing number of patients.

• #60 Diagnosis and treatment of the alpha-Gal syndrome | JAA

  https://www.dovepress.com/current-and-future-strategies-for-the-diagnosis-and-treatment-of-the-a-peer-reviewed-fulltext-article-JAA

  The AGS is an allergic disorder that challenges clinical diagnosis due to inapparent presentation and delayed reactions. […] Daily diet counseling, tick bite avoidance or environmental education should be firstly considered in customizing an accurate treatment for the AGS. […] The prevention of tick bites is relevant because continuous exposure to tick bites may maintain or increase anti–Gal IgE titers and lead to allergic responses to previously tolerated foods. […] Avoidance of mammalian meat, by-products of meat (innards), fat (gelatin and lards) and other -Gal-containing foods such as dairy products represent a crucial management strategy for AGS. […] Another major foundation for AGS management is education. […] Due to the AGS delay and unexpected symptomatology, emergency treatment is of utmost importance to correctly manage allergic reactions and potentially life-threatening anaphylaxis.

• #61 Alpha-Gal Allergy: Symptoms, Treatment, Causes, and More

  https://www.healthline.com/health/allergies/alpha-gal

  There is a lot that we dont know yet about the causes, treatment, and duration of alpha-gal allergies. If youve been bitten by a tick, be aware that an alpha-gal allergy could develop. Document any symptoms that you have. Symptoms can develop quickly within three to six hours of being bitten. […] Theres a good chance that alpha-gal allergies dont last forever. Speak to your doctor if you have a reason to suspect that youve been bitten by a lone star tick. Identifying this allergy can help you to better adjust your diet and make lifestyle choices that will prevent a dangerous allergic reaction.

• #62 About Alpha-gal Syndrome | Alpha-gal Syndrome | CDC

  https://www.cdc.gov/alpha-gal-syndrome/about/index.html

  AGS should be managed under the care of an allergist or other healthcare provider. […] Most healthcare providers recommend patients with AGS stop eating meat from mammals, such as beef, pork, lamb, venison, or rabbit. However, not all patients with AGS have reactions to every ingredient containing alpha-gal. […] You will need to work with your healthcare provider to understand which products containing alpha-gal you will need to avoid. […] Prevent tick bites. New tick bites may reactivate allergic reactions to alpha-gal. […] Talk to your healthcare provider before taking a new medication or receiving a vaccine. Although very rare, some people with severe AGS may react to ingredients in certain vaccines or medications.

• #63 Diagnosis and management of patients with the α-Gal syndrome

  https://pmc.ncbi.nlm.nih.gov/articles/PMC6980324/

  The -Gal syndrome has many novel features that are relevant to diagnosis and management. In general, the diagnosis also dictates the primary treatment, i.e. avoiding mammalian meat and also dairy in some cases. […] Blood levels of IgE to -Gal often drop in patients who avoid recurrent tick bites, but the rate of decline is variable. Similarly, the delay before reactions is variable and the severity of the allergic reactions is not predicted by the delay or the titer of specific IgE. […] The primary advice for newly diagnosed cases of the syndrome is to completely avoid meat of mammals. […] Avoiding products such as milk, yogurt, and ice cream is relatively easy because there are alternatives made from almond, oat, cashew or other non-mammalian sources. […] The argument about a dairy-free diet changes completely if consumption of -Gal containing products can contribute to inflammation without giving rise to allergic symptoms.

• #64 Life with Alpha-Gal Red Meat Allergy | Entomology

  https://entomology.ca.uky.edu/ef656

  There is no known treatment for alpha-gal syndrome. Instead, lifestyle changes can be made that help manage and reduce the symptoms. People who have alpha gal must remove beef, pork, and lamb from their diets to avoid allergic reactions. […] The symptoms of alpha-gal may decrease over time, particularly if further bites from lone star ticks are prevented. In some cases this has taken 1-2 years. More bites from ticks carrying alpha-gal though could extend the window of symptoms. […] Individuals should work with a health care provider, such as a registered dietitian, to find a diet that works for them and meets their personal nutrition needs.

• #65 The Alpha-Gal Syndrome: Unique Tick-Borne Illness on the Rise – Clinical Advisor

  https://www.clinicaladvisor.com/features/alpha-gal-syndrome-tick-borne-illness/

  Avoidance of mammalian meat, by-products of meat, fat, and other alpha-gal containing foods such as dairy products is also a critical treatment strategy for AGS. Patients should receive nutrition counseling regarding which foods can trigger allergy. They also need to understand how to attain sufficient calcium, iron, and vitamin B12 in their diet after excluding these foods. […] Symptomatic treatment of an allergy includes antihistamines, corticosteroids, cromolyn-based mast cell stabilizers, antiemetics, and antidiarrheal agents. These are pharmacologic agents that can be prescribed by the health care provider. […] Mammalian meat desensitization by oral immunotherapy (OIT) has been proposed as a promising treatment for AGS. It consists of daily intake of very small and incrementally increasing amounts of allergen in order to reduce the immune response and consequently produce allergen desensitization. However, this procedure has not been sufficiently researched for safe use at this time.

• #66 University of Illinois Chicago

  https://dig.pharmacy.uic.edu/faqs/2023-2/december-2023-faqs/what-are-institutional-perioperative-practices-for-patients-with-alpha-gal-allergy/

  Due to the increased recognition/awareness of alpha-gal allergy, recent reports have described a need to identify the presence of alpha-gal in products commonly used perioperatively due to the number of products used over a relatively short period of time in this setting. […] Specific questions related to alpha-gal allergy include asking about red meat allergy and a previous allergic reaction to cetuximab, Zostavax (live varicella zoster), or yellow fever vaccine. […] Before attributing GI symptoms after food consumption to GI intolerance or asserting a diagnosis of idiopathic anaphylaxis, healthcare providers should rule out alpha-gal allergy through patient history and IgE testing. […] According to some authors, alpha-gal IgE levels above 2 IU/mL increase the risk of severe allergic reactions.

• #67 Alpha-gal syndrome – Symptoms, diagnosis & treatment – LymeDisease.org

  https://www.lymedisease.org/alpha-gal-syndrome/

  There are currently no U.S. FDA-approved medications for the treatment of AGS. As with most allergies, the mainstay of management is avoidance of the allergen. Therefore, the best practice is to avoid exposure to: […] Knowing you must avoid mammalian products is only half the battle, as these products have worked their way into nearly every level of our modern life. […] As with all serious allergies, it is important to have the proper diagnosis and be prepared with how to respond in the event of an emergency. Most allergists will recommend wearing a medical alert bracelet and carrying an EpiPen and an antihistamine with you at all times. […] Mammalian proteins and parts can be found in many medications and medical products. […] Have your pharmacist ask specifically if it contains galactose-alpha-1,3-galactose, alpha-gal, mammalian meat, or any animal by-products.

• #68 University of Illinois Chicago

  https://dig.pharmacy.uic.edu/faqs/2023-2/december-2023-faqs/what-are-institutional-perioperative-practices-for-patients-with-alpha-gal-allergy/

  Due to the increased recognition/awareness of alpha-gal allergy, recent reports have described a need to identify the presence of alpha-gal in products commonly used perioperatively due to the number of products used over a relatively short period of time in this setting. […] Specific questions related to alpha-gal allergy include asking about red meat allergy and a previous allergic reaction to cetuximab, Zostavax (live varicella zoster), or yellow fever vaccine. […] Before attributing GI symptoms after food consumption to GI intolerance or asserting a diagnosis of idiopathic anaphylaxis, healthcare providers should rule out alpha-gal allergy through patient history and IgE testing. […] According to some authors, alpha-gal IgE levels above 2 IU/mL increase the risk of severe allergic reactions.

• #69 About Alpha-gal Syndrome | Alpha-gal Syndrome | CDC

  https://www.cdc.gov/alpha-gal-syndrome/about/index.html

  AGS should be managed under the care of an allergist or other healthcare provider. […] Most healthcare providers recommend patients with AGS stop eating meat from mammals, such as beef, pork, lamb, venison, or rabbit. However, not all patients with AGS have reactions to every ingredient containing alpha-gal. […] You will need to work with your healthcare provider to understand which products containing alpha-gal you will need to avoid. […] Prevent tick bites. New tick bites may reactivate allergic reactions to alpha-gal. […] Talk to your healthcare provider before taking a new medication or receiving a vaccine. Although very rare, some people with severe AGS may react to ingredients in certain vaccines or medications.

• #70 University of Illinois Chicago

  https://dig.pharmacy.uic.edu/faqs/2023-2/december-2023-faqs/what-are-institutional-perioperative-practices-for-patients-with-alpha-gal-allergy/

  Medications used in the perioperative setting that have been reported to contain alpha-gal are summarized in Table 1. […] Despite the increased incidence of AGS and the animal-derived source of heparin, patients with documented AGS may not necessarily demonstrate a reaction to heparin. […] A prophylactic dose of a heparin product was administered for 53 patient visits (93%). […] The patients alpha-gal IgE level was 24.2 kU/L (reference range, 0.10 kU/L). […] Successful use of bivalirudin as an alternative to heparin is described in a patient undergoing percutaneous coronary intervention (PCI) and left ventricular assist device (LVAD) replacement. […] Based on the available data, a suggested algorithm by Nourian et al can help guide the decision for heparin use in patients with AGS.

• #71 University of Illinois Chicago

  https://dig.pharmacy.uic.edu/faqs/2023-2/december-2023-faqs/what-are-institutional-perioperative-practices-for-patients-with-alpha-gal-allergy/

  In all cases, alpha-gal IgE levels and an allergist consultation are recommended (either before or after the procedure). […] Until more evidence becomes available, health care providers, health care systems, and product manufacturers need to ensure availability and familiarity with medications and products that are alpha-gal free. […] In the case of heparin, several options include alternate anticoagulants, skin testing, and heparin desensitization and depend on alpha-gal IgE levels and urgency of the procedure.

• #72 Diagnosis and treatment of the alpha-Gal syndrome | JAA

  https://www.dovepress.com/current-and-future-strategies-for-the-diagnosis-and-treatment-of-the-a-peer-reviewed-fulltext-article-JAA

  The AGS is an allergic disorder that challenges clinical diagnosis due to inapparent presentation and delayed reactions. […] Daily diet counseling, tick bite avoidance or environmental education should be firstly considered in customizing an accurate treatment for the AGS. […] The prevention of tick bites is relevant because continuous exposure to tick bites may maintain or increase anti–Gal IgE titers and lead to allergic responses to previously tolerated foods. […] Avoidance of mammalian meat, by-products of meat (innards), fat (gelatin and lards) and other -Gal-containing foods such as dairy products represent a crucial management strategy for AGS. […] Another major foundation for AGS management is education. […] Due to the AGS delay and unexpected symptomatology, emergency treatment is of utmost importance to correctly manage allergic reactions and potentially life-threatening anaphylaxis.

• #73 Health Care Provider Knowledge Regarding Alpha-gal Syndrome — United States, March–May 2022 | MMWR

  https://www.cdc.gov/mmwr/volumes/72/wr/mm7230a1.htm

  No treatment or cure is currently available. […] Limited awareness and knowledge of AGS among HCPs likely contributes to underdiagnosis of this condition and inadequate patient management, and underestimates of the number of AGS patients in the United States, which currently relies on laboratory testing data alone. […] A growing number of resources are available for HCPs seeking additional education related to the evaluation, diagnosis, and management of patients with AGS. […] Increased HCP education and awareness of AGS are needed to hasten and improve the accuracy of AGS diagnoses, patient care, and the understanding of the epidemiology of this emerging condition.

• #74 Alpha-gal syndrome – Symptoms, diagnosis & treatment – LymeDisease.org

  https://www.lymedisease.org/alpha-gal-syndrome/

  There are currently no U.S. FDA-approved medications for the treatment of AGS. As with most allergies, the mainstay of management is avoidance of the allergen. Therefore, the best practice is to avoid exposure to: […] Knowing you must avoid mammalian products is only half the battle, as these products have worked their way into nearly every level of our modern life. […] As with all serious allergies, it is important to have the proper diagnosis and be prepared with how to respond in the event of an emergency. Most allergists will recommend wearing a medical alert bracelet and carrying an EpiPen and an antihistamine with you at all times. […] Mammalian proteins and parts can be found in many medications and medical products. […] Have your pharmacist ask specifically if it contains galactose-alpha-1,3-galactose, alpha-gal, mammalian meat, or any animal by-products.

• #75 What Health Officials Should Know About Alpha-Gal Syndrome | ASTHO

  https://www.astho.org/communications/blog/what-health-officials-should-know-about-alpha-gal-syndrome/

  Unfortunately, no treatment or cure for AGS is currently available. Management of AGS includes the use of antihistamines, epinephrine, and eliminating red meat and other alpha-gal-containing products from the diet. […] No treatment or cure is currently availableprevent tick bites to prevent AGS.

• #76

  https://link.springer.com/article/10.1007/s40521-023-00353-6

  Alpha-gal (-gal) syndrome (AGS) represents a paradigm shift in food allergy since the allergen (-gal), unlike most protein allergens, is an oligosaccharide found in mammalian meat and because of the delayed onset of allergic symptoms (3 to 6 h after consumption). […] Treatment is based on avoiding mammalian meat consumption and in some cases also mammalian-derived products. […] In recent years, a few studies of oral desensitization against -gal have been published with promising results. […] Future treatment strategies may involve combining anti-IgE therapy with oral desensitization to improve management outcomes. […] This report described the first successful desensitization protocol to red meat in adults with alpha-gal syndrome. […] This is the most recent study on the success of alpha-gal oral immunotherapy in a group of patients with alpha-gal syndrome.

• #77 Tick-borne red meat allergy prevented in mice through new nanoparticle treatment – Chemical Engineering

  https://che.engin.umich.edu/2024/08/12/tick-borne-red-meat-allergy-prevented-in-mice-through-new-nanoparticle-treatment/

  Nanoparticles delivered intravenously in mice can block the allergic reactions to red meat caused by the bite of the lone star tick, new research led by the University of Michigan shows. […] Developed at U-M, the nanoparticles contain allergens that retrain the immune system to ignore the type of sugar found in beef, pork, lamb and other mammals. […] „Treating food allergies usually means de-sensitizing patients to the allergen so that their immune system does not react inappropriately,” said Lonnie Shea, the Steven A. Goldstein Collegiate Professor of Biomedical Engineering and Professor of Chemical Engineering at U-M and co-corresponding author on the study. „Our nanoparticles, when introduced prior to or after sensitization, have been remarkably effective in reducing the immune response in multiple food allergies.”

• #78 Diagnosis and treatment of the alpha-Gal syndrome | JAA

  https://www.dovepress.com/current-and-future-strategies-for-the-diagnosis-and-treatment-of-the-a-peer-reviewed-fulltext-article-JAA

  The anti-IgE agent omalizumab has been sporadically used in specialized centers as monotherapy in AGS patients for successfully controlling continued reactivity, allowing the introduction of a small amount of mammalian meat in their diet. […] Management of FAs is becoming less generic and more target oriented.

• #79 What to know about alpha-gal syndrome | I.M. Matters from ACP

  https://immattersacp.org/archives/2024/01/what-to-know-about-alpha-gal-syndrome.htm

  Alpha-gal syndrome is not a nationally notifiable condition, so states are not required to report their cases of alpha-gal syndrome to the CDC, so our national awareness of case counts is limited to examining lab testing data. […] We did develop a Medscape CME training for health care providers to help increase knowledge around alpha-gal syndrome. […] A key component of preventing alpha-gal syndrome is preventing tick bites, so taking those same actions that we know can prevent Lyme disease, ehrlichiosis, other tick-borne diseases wearing an EPA-approved tick repellent, showering, and checking for ticks when you return inside are really critical. We know that there is no treatment for alpha-gal syndrome and so prevention is especially important.

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