Materiały źródłowe

• #1 Can Bile Duct Cancer Be Prevented? | Preventing Bile Duct Cancer | American Cancer Society

  https://www.cancer.org/cancer/types/bile-duct-cancer/causes-risks-prevention/be-prevented.html

  There’s no known way to prevent most bile duct cancers in the US. Many of the known risk factors for bile duct cancer, such as age, ethnicity, and bile duct abnormalities, are beyond our control. However, there are things you can do that might help lower your risk. […] Getting to and staying at a healthy weight is one important way you might be able to reduce your risk of bile duct cancer, as well as many other types of cancer. […] The American Cancer Society recommends that people try to stay at a healthy weight, keep physically active, and follow a healthy eating pattern. This includes eating plenty of fruits, vegetables, and whole grains, and limiting or avoiding red and processed meats, sugary drinks, and highly processed foods. […] Other ways you might be able to reduce your risk of bile duct cancer include:

• #2

  https://winshipcancer.emory.edu/cancer-types-and-treatments/bile-duct-cancer/prevention.php

  Cholangiocarcinoma is relatively rare in the U.S. Still, its important to learn about bile duct cancer prevention so you can protect yourself. […] While researchers are still working to understand exactly what causes bile duct cancer and have yet to make specific recommendations regarding bile duct cancer prevention, they have identified some risk factors for the disease. […] While theres no reliable way to prevent cholangiocarcinoma, the following bile duct cancer prevention recommendations may help you reduce your risk for developing the disease: […] Get vaccinated against hepatitis B and take steps to prevent infection with hepatitis C […] Limit alcohol use […] Dont smoke […] Maintain a body mass index below 25 […] Be physically active every day […] Eat a diet rich in fruits and vegetables and limit red and processed meat.

• #3 Bile Duct Cancer: Overview | Cedars-Sinai

  https://www.cedars-sinai.org/health-library/diseases-and-conditions/b/bile-duct-cancer-overview.html

  There’s no sure way to prevent bile duct cancer. Some risk factors can be controlled or treated to help reduce risk. […] Talk with your healthcare provider about your risk factors for bile duct cancer and what you can do about them.

• #4 Cholangiocarcinoma, a rare tumor of the bile duct – Servier

  https://servier.com/en/newsroom/folders/cholangiocarcinoma-a-rare-tumor-of-the-bile-duct/

  Cholangiocarcinoma can be partially prevented through appropriate lifestyle and health measures. Adopting a balanced diet rich in fruits and vegetables, combined with regular physical activity, helps maintain a healthy liver. […] Similarly, limiting alcohol consumption and avoiding smoking are essential measures to protect the liver. […] It is crucial to get vaccinated against the hepatitis B virus (HBV) to prevent chronic infections that may lead to this cancer. […] Treating any existing hepatitis, especially hepatitis B and C, reduces the risk of liver damage that could develop into cholangiocarcinoma. […] By combining these various strategies, it is possible to significantly reduce the risk of developing cholangiocarcinoma.

• #5 Explore Bile Duct Cancer Prevention Risk factors and Prevention Measures at HCG Oncology

  https://www.hcgoncology.com/types-of-cancers/bile-duct-cancer-prevention/

  Bile Duct Cancer Prevention Measures […] Several people, especially those with high bile duct cancer risk, ask about how to prevent bile duct cancer or how to avoid bile duct cancer. Complete bile duct cancer prevention may not be possible; however, certain strategies may help lower its risk. The following are some of the effective bile duct cancer prevention measures: […] Maintaining a healthy weight is an important bile duct cancer prevention measure. People with obesity are prone to developing various bile duct and liver-related conditions. These include NAFLD, gallstones, and bile duct stones. Further, obese people are at risk of developing insulin resistance, leading to diabetes. Diabetes is another risk factor for bile duct cancer. […] Limiting the consumption of alcohol can increase the chances of bile duct cancer prevention. People with underlying liver diseases should completely avoid its consumption.

• #6 Understanding Gallbladder and Bile Duct Cancer: A Comprehensive Overview | GW Cancer Center

  https://cancercenter.gwu.edu/news/understanding-gallbladder-and-bile-duct-cancer-comprehensive-overview

  While it may not be possible to prevent gallbladder and bile duct cancer entirely, certain measures can help reduce the risk: […] Maintain a healthy weight and lifestyle. […] Eat a balanced diet with plenty of fruits and vegetables. […] Exercise regularly. […] Seek prompt medical attention for gallbladder or digestive system issues. […] If you smoke, try to reduce the number of cigarettes you smoke or quit smoking altogether.

• #7 Prevention & Treatment of Gallbladder Cancer and Bile Duct Cancer – Premier Surgical

  https://www.premiersurgical.com/02/prevention-treatment-of-gallbladder-cancer-and-bile-duct-cancer/

  February marks Gallbladder Cancer and Bile Duct Cancer Awareness Month, a time to shed light on these relatively rare but serious cancers. […] While there is no guaranteed way to prevent gallbladder and bile duct cancers, certain lifestyle changes can reduce risk: […] Maintaining a healthy weight through a balanced diet and regular exercise can lower this risk. […] A diet rich in fruits, vegetables, and whole grains, and low in processed and fatty foods, can contribute to overall liver and gallbladder health. […] Exposure to certain industrial chemicals and toxins may increase the risk of bile duct cancer. Its essential to follow safety guidelines if you work in environments with these substances. […] Regular medical check-ups can help identify risk factors, such as gallstones or liver diseases, which may increase the risk of these cancers. […] Awareness, early detection, and advanced treatment options are key to combating gallbladder and bile duct cancers. This February, lets spread awareness about these cancers and the importance of prevention and early intervention.

• #8 Can Bile Duct Cancer Be Prevented? | Preventing Bile Duct Cancer | American Cancer Society

  https://www.cancer.org/cancer/types/bile-duct-cancer/causes-risks-prevention/be-prevented.html

  Get vaccinated against the hepatitis B virus (HBV) to prevent infection with the virus and the cirrhosis it can cause. […] Take precautions to avoid blood-borne or sexually transmitted infections like HBV, hepatitis C, and other viruses that can cause cirrhosis. […] Treat hepatitis infections (such as B and C) to help prevent cirrhosis. […] If you do drink, have no more than 1 drink per day for women or 2 drinks per day for men. […] Quit (or don’t start) smoking. […] Protect yourself against exposure to certain chemicals. […] If you travel to parts of the world where liver flukes are common, drink only purified water and eat only foods that have been thoroughly cooked.

• #9 Bile duct cancer | NHS inform

  https://www.nhsinform.scot/illnesses-and-conditions/cancer/cancer-types-in-adults/bile-duct-cancer-cholangiocarcinoma/

  There are no guaranteed ways to avoid getting bile duct cancer, but you can reduce your chances of developing it. […] The most effective ways of achieving this are reducing your alcohol intake, as cirrhosis is a risk factor, and trying to ensure that you don’t become infected with hepatitis B or hepatitis C. […] The 3 most effective steps to reduce your chances of developing bile duct cancer are: giving up smoking (if you smoke), drinking alcohol in moderation, minimising your exposure to the hepatitis B and hepatitis C viruses. […] Not smoking is the most effective way of preventing bile duct cancer, as well as other serious health conditions, such as stroke, heart attack and lung cancer. […] If you are a heavy drinker, reducing your alcohol intake will help prevent liver damage (cirrhosis). This may, in turn, reduce your risk of developing bile duct cancer. […] A vaccine is available that provides immunisation against hepatitis B. […] The liver fluke is a major cause of bile duct cancer in Asia. It is a parasite which, after infection, damages the tissue of the bile duct and in some cases triggers the onset of bile duct cancer.

• #10 Cholangiocarcinoma (bile duct cancer) | UM Health-Sparrow

  https://www.uofmhealthsparrow.org/departments-conditions/conditions/cholangiocarcinoma-bile-duct-cancer

  To reduce your risk of cholangiocarcinoma, you can: […] Stop smoking. Smoking is linked to an increased risk of cholangiocarcinoma. If you smoke, stop. If you have tried quitting in the past and haven’t been successful, talk with your doctor about strategies to help you quit. […] Reduce your risk of liver disease. Chronic liver disease is associated with an increased risk of cholangiocarcinoma. Some causes of liver disease can’t be prevented, but others can. Do what you can to take care of your liver. […] For instance, to reduce your risk of liver inflammation (cirrhosis), drink alcohol in moderation, if you choose to drink. For healthy adults, that means up to one drink a day for women and up to two drinks a day for men. Maintain a healthy weight. When working with chemicals, follow the safety instructions.

• #11 Bile Duct Cancer – Prevention

  https://ruesch.georgetown.edu/bileductcancerprevention/

  Avoiding risk factors and increasing protective factors may help prevent cancer. […] Chronic Hepatitis B and C infections are risk factors that may lead to liver cancer. […] The following protective factors may decrease the risk of liver cancer: Hepatitis B vaccine, Treatment for chronic hepatitis B infection, Reduced exposure to aflatoxin B1. […] Cancer prevention clinical trials are used to study ways to prevent cancer. […] New ways to prevent liver cancer are being studied in clinical trials.

• #12 Cholangiocarcinoma (Bile Duct Cancer) Causes & Risk Factors

  https://www.cancercenter.com/cancer-types/bile-duct-cancer/risk-factors

  While its not always possible to prevent bile duct cancer, a number of steps patients may take have been found to help lower the risk. Among them: […] Maintain a healthy weight and stay physically active. […] Avoid risky behaviors, such as needle sharing, that may increase the risk of contracting hepatitis C. […] Prevent hepatitis B by getting vaccinated against it. […] Limit or avoid alcohol consumption. […] Quit smoking. […] Avoid exposure to chemicals such as asbestos, radon and dioxin.

• #13 Explore Bile Duct Cancer Prevention Risk factors and Prevention Measures at HCG Oncology

  https://www.hcgoncology.com/types-of-cancers/bile-duct-cancer-prevention/

  As a bile duct cancer prevention measure, one must prevent chronic exposure to these chemicals with the help of protective equipment, such as face shields, chemical-resistant gloves, chemical-resistant glasses, respiratory equipment, shoe covers, etc. […] The different bile duct cancer prevention strategies include maintaining a healthy weight, refraining from alcohol and tobacco consumption, and avoiding chemical exposure.

• #14 Cholangiocarcinoma | Bile Duct Cancer, Asbestos Link

  https://mesothelioma.net/cholangiocarcinoma/

  Knowing more about the causes of cholangiocarcinoma can help people avoid risk factors that could lead to a cancer diagnosis. People are less likely to be exposed to asbestos today, but it is still a risk factor. […] It is important to avoid asbestos, especially in older homes, and rely on asbestos professionals to find and abate the material. […] It is also important to be aware of safety regulations in the workplace, especially where exposure is possible. […] Cholangiocarcinoma is a cancer that may be triggered by asbestos exposure; however, many people develop the disease without experiencing any known exposure. […] Regardless of the cause, it is important to seek a diagnosis and treatment as early as possible.

• #15 Prevention of bile duct cancer in primary sclerosing cholangitis – PubMed

  https://pubmed.ncbi.nlm.nih.gov/10436824/

  Patients with primary sclerosing cholangitis (PSC) have a substantial predisposition to develop bile duct carcinoma. […] However, there is still no effective medical therapy which can halt the progression of the disease or prevent the development of cholangiocarcinoma. […] Ideally, screening patients with PSC would allow the identification of those with dysplastic change in the biliary epithelia before the development of overt carcinoma. […] However, although serum tumour markers such as CA 19.9 and CEA can be of value in aiding the diagnosis of cholangiocarcinoma in PSC there is currently no evidence that they are helpful in identifying those patients with premalignant changes of the biliary epithelia who would benefit from surgery. […] A recent report has suggested that regular biliary cytology sampling to detect dysplasia can predict the development of cholangiocarcinoma. However, regular instrumentation of the biliary tree to obtain cytology is unlikely to be widely adopted.

• #16 Bile Duct Cancer Risk Factors | Parrish Medical Center

  https://www.parrishhealthcare.com/news/2019/february/how-to-lower-your-risk-of-bile-duct-cancer/

  Though it might be impossible to prevent the occurrence of bile duct cancer completely, there are some things you can do to reduce your risk. […] One of the best methods of prevention is to participate in regular checkups and communicate with your doctor if you are feeling symptoms that are out of the ordinary. Older persons, as well as those possessing any of the preceding risk factors, should receive a thorough medical evaluation.

• #17 Cholangiocarcinoma Awareness Month: Symptoms, Risks

  https://txhospitals.in/cholangiocarcinoma-awareness-month-symptoms-risks-prevention-tips/

  Cholangiocarcinoma Awareness Month: Symptoms, Risks Prevention Tips […] February is Cholangiocarcinoma Awareness Month, a time to raise awareness for this rare but aggressive cancer. […] Increased awareness can result in: […] Understanding these risk factors might help people take preventative measures and, if necessary, schedule regular check-ups. […] Awareness empowers people, helps patients, and propels research ahead. This February, take the initiative to spread the word, educate yourself, and promote preventive healthcare. […] While some risk factors, such as heredity, cannot be altered, certain lifestyle changes can help lessen the risk of developing cholangiocarcinoma. […] Regular check-ups are recommended for individuals with risk factors. Consult your doctor for screening alternatives. […] By raising awareness and seeking treatment earlier, we can help enable a future where treatment options are better and survival rates are higher.

• #18 Aspirin Use May Help Prevent Bile Duct Cancer – Mayo Clinic News Network

  https://newsnetwork.mayoclinic.org/discussion/aspirin-use-may-help-prevent-bile-duct-cancer-mayo-led-study-finds/

  A team of current and former Mayo Clinic researchers has discovered that aspirin use is associated with a significantly reduced risk of developing bile duct cancer, also called cholangiocarcinoma. […] “Our study found that individuals who took aspirin had a more than a two-and-a-half to three-and-a-half-fold lesser chance of developing bile duct cancer, compared to individuals who did not take aspirin,” says Lewis Roberts, M.B. Ch.B., Ph.D., the study’s senior author and a gastroenterologist and hepatologist at Mayo Clinic. […] “We know that continuous unremitting inflammation is one of the main factors that promotes cancer of the bile ducts,” Dr. Roberts says. “Aspirin, with its anti-inflammatory properties, may reduce the risk of bile duct cancer by lessening inflammation through inhibition of an enzyme called cyclo-oxygenase (COX), which is known to promote inflammation.”

• #19 February is Gallbladder & Bile Duct Cancer Month – Cancer Exercise Training Institute

  https://www.thecancerspecialist.com/2020/02/27/february-is-gallbladder-bile-duct-cancer-month/

  According to the Mayo Clinic, there was a study published in 2016 that showed aspirin use may help reduce the risk of developing cholangiocarcinoma. The study involved data on nearly 4,800 people. Further study is needed to be certain that long-term aspirin use is safe for cancer prevention. […] Lymphatic drainage exercises, a slow, gradual warm-up, and a slow gradual progression of cardiovascular and strength training exercises will be necessary to prevent and monitor for lymphedema. […] The exercise environment should be impeccably clean and sessions should be cancelled if the CES is sick because of the patients diminished ability to fight infection. […] The same precautions will need to be taken as were mentioned previously.

• #20 Aspirin Use May Help Prevent Bile Duct Cancer – Mayo Clinic News Network

  https://newsnetwork.mayoclinic.org/discussion/aspirin-use-may-help-prevent-bile-duct-cancer-mayo-led-study-finds/

  But, it is not certain that aspirin is safe to use for cancer prevention. Dr. Roberts and his colleagues say additional confirmatory studies are needed before aspirin can be recommended for use in preventing bile duct cancer. Future plans will include population-based studies designed to confirm the associations of aspirin with decreased risk of developing bile duct cancer and clinical trials of aspirin in people at high risk for developing bile duct cancer.

• #21 Cholangiocarcinoma | Nature Reviews Disease Primers

  https://www.nature.com/articles/s41572-021-00300-2

  Cholangiocarcinoma (CCA) is a highly lethal adenocarcinoma of the hepatobiliary system, which can be classified as intrahepatic, perihilar and distal. […] In endemic regions, liver fluke infection is associated with CCA, owing to the oncogenic effect of the associated chronic biliary tract inflammation. Administration of the anthelmintic drug praziquantel decreases the risk of CCA from liver flukes, but reinfection is common and future vaccination strategies may be more effective. […] CCA remains a highly lethal disease and further scientific and clinical insights are needed to improve patient outcomes.

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