Materiały źródłowe

• #1 Aplastic Anemia: Symptoms, Causes & Treatment

  https://my.clevelandclinic.org/health/diseases/16747-aplastic-anemia

  Aplastic anemia symptoms usually develop over weeks and months, so you may not notice changes in your body right away. In some cases, people have immediate severe symptoms. If you do develop symptoms, they may include: Frequent viral infections that last longer than usual. Fatigue. Bleeding or bruising more easily. Feeling short of breath (dyspnea). Skin color that’s paler than usual. Dizziness. Headache. Fever. […] Some aplastic anemia symptoms mimic other, less serious illnesses. Having a cold or flu doesn’t mean you have aplastic anemia. You should talk to a healthcare provider if you’ve been sick for several weeks and you feel very tired all the time. […] People with aplastic anemia may have the following complications, some of which may be life-threatening: Anemia. Severe infections. Excessive bleeding. Arrhythmia or heart failure. Myelodysplastic syndrome.

• #2 Aplastic anemia | Altru Health System

  https://www.altru.org/health-library/conditions/aplastic-anemia

  Aplastic anemia is a condition that happens when your bone marrow stops making enough new blood cells. The condition leaves you tired and more prone to infections and uncontrolled bleeding. […] Aplastic anemia can have no symptoms. When present, symptoms can include: Fatigue. Shortness of breath. Rapid or irregular heart rate. Frequent or prolonged infections. Unexplained or easy bruising. Nosebleeds and bleeding gums. Prolonged bleeding from cuts. Pale skin. Skin rash. Fever. […] Aplastic anemia can be short-lived, or it can become chronic. It can be serious and even fatal.

• #3 Aplastic Anemia – Hematology and Oncology – Merck Manual Professional Edition

  https://www.merckmanuals.com/professional/hematology-and-oncology/anemias-caused-by-deficient-erythropoiesis/aplastic-anemia

  Aplastic anemia is a disorder of the hematopoietic stem cell that results in a loss of blood cell precursors, hypoplasia or aplasia of bone marrow, and cytopenias in two or more cell lines (red blood cells, white blood cells, and/or platelets). Symptoms result from anemia, thrombocytopenia (petechiae, bleeding), or leukopenia (infections). […] The onset of aplastic anemia usually is insidious, often occurring over weeks or months after exposure to a virus, medication or toxin (eg, insecticides, benzene), though occasionally it can be acute. […] In aplastic anemia, anemia may cause weakness and easy fatigability while severe thrombocytopenia may cause petechiae, ecchymosis, and bleeding from the gums, into the conjunctivae, or other tissues. Agranulocytosis commonly causes life-threatening infections. Splenomegaly is absent unless induced by transfusion hemosiderosis.

• #4 Symptoms & Causes of Aplastic Anemia & Myelodysplastic Syndromes – NIDDK

  https://www.niddk.nih.gov/health-information/blood-diseases/aplastic-anemia-myelodysplastic-syndromes/symptoms-causes

  The symptoms of aplastic anemia and MDS are very similar. Symptoms of the disorders may include fatigue or tiredness […] Symptoms vary from person to person, depending on which type of blood cells are most affected and the cause of the disorder. In the early stages of MDS, you may have only mild symptoms or no symptoms at all. Severe aplastic anemia and higher-risk MDS, which occur when you have very low levels of one or more types of blood cells, can be life-threatening if not treated right away.

• #5 Aplastic Anemia – Seattle Children’s

  https://www.seattlechildrens.org/conditions/aplastic-anemia/

  Aplastic anemia can cause low levels of white blood cells, red blood cells or platelets. Most children with this disease have low levels of all 3 types of cells. […] Your child’s symptoms will depend on which cells are low and how low they are. Your child may: […] Have more infections and not get over them as quickly as other children. Low levels of white blood cells increase the risk of infection. […] Be tired, dizzy or short of breath. Without enough red blood cells (anemia), your child may have low energy or these other symptoms. […] Bruise or bleed easily because of low platelet levels. […] Some people with aplastic anemia do not notice any symptoms. They may learn about a problem after a routine blood test is done for another reason.

• #6 Aplastic anaemia – Leukaemia Foundation

  https://www.leukaemia.org.au/blood-cancer/types-of-blood-cancer/aplastic-anaemia/

  Aplastic anaemia is a rare disorder in which the bone marrow fails to produce enough blood cells. This happens because the normal blood forming cells (stem cells) are replaced by abnormal fat cells. […] Although aplastic anaemia is not a malignant disease (cancer) it can be very serious, especially if the bone marrow is severely affected and there are very few blood cells left in circulation. Without adequate numbers of blood cells people with aplastic anaemia can become anaemic (low red blood cells) and more susceptible to infections (low white blood cells), and to bleeding and bruising more easily (low platelets). […] The main symptoms of aplastic anaemia are caused by a lack of normal blood cells. Common symptoms include: anaemia due to a lack of red cells, causing persistent tiredness, dizziness, paleness, or shortness of breath when physically active; frequent or repeated infections and slow healing, due to a lack of normal white cells, especially neutrophils; increased or unexplained bleeding or bruising, due to a very low platelet count. […] Occasionally people have no symptoms at all and aplastic anaemia is diagnosed during a routine blood test. Some of these symptoms described may also be seen in other illnesses, including viral infections, so it is important to see your doctor so that you can be examined and treated properly.

• #7 What Are the Signs and Symptoms of Aplastic Anemia? | Hematology-Oncology Associates of CNY

  https://www.hoacny.com/patient-resources/blood-disorders/aplastic-anemia/what-are-signs-and-symptoms-aplastic-anemia

  Lower than normal numbers of red blood cells, white blood cells, and platelets cause most of the signs and symptoms of aplastic anemia. […] The most common symptom of a low red blood cell count is fatigue (tiredness). A low red blood cell count also can cause shortness of breath; dizziness, especially when standing up; headaches; coldness in your hands or feet; pale skin; and chest pain. […] White blood cells help fight infections. Signs and symptoms of a low white blood cell count include fevers, frequent infections that can be severe, and flu-like illnesses that linger. […] People who have low platelet counts tend to bruise and bleed easily, and the bleeding may be hard to stop. Common types of bleeding associated with a low platelet count include nosebleeds, bleeding gums, pinpoint red spots on the skin, and blood in the stool. Women also may have heavy menstrual bleeding.

• #8 Aplastic Anemia: Types, Symptoms, Causes & Treatment

  https://www.webmd.com/a-to-z-guides/aplastic-anemia

  Aplastic anemia symptoms may come on gradually or appear suddenly and severely. Your symptoms may vary depending on what types of blood cells you’re low on, but you may be low on all three. […] Symptoms of low red blood cell count include tiredness, shortness of breath, dizziness, pale skin, headaches, chest pain, and fast heartbeat. […] Symptoms of low white blood cell count include infections and fever. […] Symptoms of low platelet count include easy bruising and bleeding, and nosebleeds.

• #9 Aplastic anemia Information | Mount Sinai – New York

  https://www.mountsinai.org/health-library/diseases-conditions/aplastic-anemia

  Aplastic anemia is a condition in which the bone marrow does not make enough blood cells. Bone marrow is the soft, tissue in the center of bones that is responsible for producing blood cells and platelets. […] Symptoms are due to the underproduction of red cells, white cells, and platelets. Symptoms may be severe from the start or gradually worsen over time as the disease progresses. […] Low red cell count (anemia) can cause: Fatigue, Pallor (paleness), Rapid heart rate, Shortness of breath with exercise, Weakness, Lightheadedness upon standing. […] Low white cell count (leukopenia) causes an increased risk for infection. […] Low platelet count (thrombocytopenia) can result in bleeding. Symptoms include: Bleeding gums, Easy bruising, Nose bleeds, Rash, small pinpoint red marks on the skin (petechiae), Frequent or severe infections (less common).

• #10 Aplastic Anemia Symptoms | Aplastic Anemia and MDS International Foundation (AAMDSIF)

  https://www.aamds.org/aplastic-anemia/symptoms

  Aplastic anemia symptoms vary from person to person. Specific symptoms depend on which of your blood cell types are affected and how low your blood counts have fallen. […] A low red blood cell count is called anemia. If you have a low red blood cell count, you may: Feel a little tired or very tired, Feel less alert or have trouble concentrating, Have a loss of appetite or lose weight, Have paler-than-normal skin, Have trouble breathing, Have rapid heartbeat, Have difficulty exercising or climbing stairs. […] A low white blood cell count is called neutropenia. In general, a low white cell count lowers an aplastic anemia patient’s ability to fight bacterial infections. If you have a low white blood cell count, you may: Have repeated fevers and infections, Get bladder infections that make it painful to urinate or make you urinate more often, Get lung infections that cause coughing and difficulty breathing, Get mouth sores, Get sinus infections and a stuffy nose, Get skin infections. A fever in an aplastic anemia patient is potentially serious. A doctor should be notified if a fever occurs.

• #11 Aplastic Anemia – Together by St. Jude™

  https://together.stjude.org/en-us/conditions/blood-disorders/aplastic-anemia.html

  Aplastic anemia is a rare blood disorder that occurs when bone marrow does not make enough blood cells. It is a type of bone marrow failure. […] Aplastic anemia can develop at any age. It is a severe and life-threatening blood disorder. […] Symptoms are caused by low numbers of red blood cells, white blood cells, and platelets. Your child’s signs and symptoms depend on which type of blood cell is affected and the severity of their condition. […] Low red blood cells (anemia) can cause fatigue or feeling tired, pale skin, gums, or nail beds, headache, dizziness or feeling lightheaded, cold hands or feet, fast or irregular heart rate, and shortness of breath. […] Low white blood cells (leukopenia) and low neutrophils (neutropenia) can cause fever, more infections than normal, especially from bacteria or fungi, and mouth ulcers.

• #12 Content – Health Encyclopedia – University of Rochester Medical Center

  https://www.urmc.rochester.edu/encyclopedia/content?ContentTypeID=90&ContentID=P02312

  Aplastic anemia is a serious condition in which the bone marrow doesnt make enough new blood cells. With fewer blood cells, a child with aplastic anemia has: […] The most common symptoms of aplastic anemia are below. […] Low levels of red blood cells can cause: Pale skin, Chest pain, Irregular heart beat, Enlarged heart. […] Low levels of white blood cells can cause: Fevers, Mouth sores, Infections. […] Low levels of platelets can cause: Easy bruising, Nosebleeds, Bleeding gums, Blood in the stool, Heavy bleeding with menstrual periods. […] Other symptoms can include: Nausea, Skin rashes. […] Some symptoms include tiredness, paleness, frequent infections, and easy bruising and bleeding.

• #13 What Are the Signs and Symptoms of Aplastic Anemia? | Hematology-Oncology Associates of CNY

  https://www.hoacny.com/patient-resources/blood-disorders/aplastic-anemia/what-are-signs-and-symptoms-aplastic-anemia

  Lower than normal numbers of red blood cells, white blood cells, and platelets cause most of the signs and symptoms of aplastic anemia. […] The most common symptom of a low red blood cell count is fatigue (tiredness). A low red blood cell count also can cause shortness of breath; dizziness, especially when standing up; headaches; coldness in your hands or feet; pale skin; and chest pain. […] White blood cells help fight infections. Signs and symptoms of a low white blood cell count include fevers, frequent infections that can be severe, and flu-like illnesses that linger. […] People who have low platelet counts tend to bruise and bleed easily, and the bleeding may be hard to stop. Common types of bleeding associated with a low platelet count include nosebleeds, bleeding gums, pinpoint red spots on the skin, and blood in the stool. Women also may have heavy menstrual bleeding.

• #14 Aplastic Anemia Symptoms | Aplastic Anemia and MDS International Foundation (AAMDSIF)

  https://www.aamds.org/aplastic-anemia/symptoms

  Aplastic anemia symptoms vary from person to person. Specific symptoms depend on which of your blood cell types are affected and how low your blood counts have fallen. […] A low red blood cell count is called anemia. If you have a low red blood cell count, you may: Feel a little tired or very tired, Feel less alert or have trouble concentrating, Have a loss of appetite or lose weight, Have paler-than-normal skin, Have trouble breathing, Have rapid heartbeat, Have difficulty exercising or climbing stairs. […] A low white blood cell count is called neutropenia. In general, a low white cell count lowers an aplastic anemia patient’s ability to fight bacterial infections. If you have a low white blood cell count, you may: Have repeated fevers and infections, Get bladder infections that make it painful to urinate or make you urinate more often, Get lung infections that cause coughing and difficulty breathing, Get mouth sores, Get sinus infections and a stuffy nose, Get skin infections. A fever in an aplastic anemia patient is potentially serious. A doctor should be notified if a fever occurs.

• #15 Aplastic Anemia – Together by St. Jude™

  https://together.stjude.org/en-us/conditions/blood-disorders/aplastic-anemia.html

  Aplastic anemia is a rare blood disorder that occurs when bone marrow does not make enough blood cells. It is a type of bone marrow failure. […] Aplastic anemia can develop at any age. It is a severe and life-threatening blood disorder. […] Symptoms are caused by low numbers of red blood cells, white blood cells, and platelets. Your child’s signs and symptoms depend on which type of blood cell is affected and the severity of their condition. […] Low red blood cells (anemia) can cause fatigue or feeling tired, pale skin, gums, or nail beds, headache, dizziness or feeling lightheaded, cold hands or feet, fast or irregular heart rate, and shortness of breath. […] Low white blood cells (leukopenia) and low neutrophils (neutropenia) can cause fever, more infections than normal, especially from bacteria or fungi, and mouth ulcers.

• #16 Severe Aplastic Anemia – Leukemia / Bone Marrow Transplant Program

  https://www.leukemiabmtprogram.org/patients-support-givers/diseases-treatments/severe-aplastic-anemia/

  Platelets are cells that help the blood to clot. Some chemotherapy drugs can cause your bone marrow to make fewer platelets. If you have a very low platelet count, you may get symptoms such as: Bruises on the skin without an apparent injury, Bleeding from the gums or nose, Blood blisters in the mouth, Pinhead-sized red spots in the skin, especially on the lower legs and feet. These are called petechiae. […] Neutrophils are one of the types of white blood cells. These cells are important in protecting you from infection. Chemotherapy will temporarily affect your bone marrows ability to make neutrophils. A fever can be a sign of infection. If you have a fever when your neutrophils are low, we may need to act quickly to give you antibiotics to stop a potential infection from causing serious harm.

• #17 Severe Aplastic Anemia – Leukemia / Bone Marrow Transplant Program

  https://www.leukemiabmtprogram.org/patients-support-givers/diseases-treatments/severe-aplastic-anemia/

  Fatigue is a feeling of being very tired. It is a common symptom felt by people with SAA. It is caused by a combination of many factors such as low blood counts, underlying infections, eating less food due to loss of appetite and being less active. […] White blood cells make up an individuals immune system. Normally, these cells protect you from bacteria, viruses and other harmful organisms you encounter every day. However, individuals with SAA have a weakened immune system due to not having enough white blood cells. It makes an individual more prone to infections and they may get more sick than usual when they develop a common infection. […] Having a fever is a common symptom of an infection. It is an important sign that your body may be fighting an infection.

• #18 Aplastic Anemia in Children

  https://www.nationwidechildrens.org/conditions/health-library/aplastic-anemia-in-children

  Aplastic anemia occurs when the bone marrow produces too few of all types of blood cells: red cells, white cells, and platelets. A reduced number of red blood cells causes the red cell number and hemoglobin (a type of protein in the red blood cells that carries oxygen to the tissues of the body) to drop. A reduced number of white blood cells causes the patient to be susceptible to infection. A reduced number of platelets can cause the blood not to clot the way it should. […] The following are the most common symptoms of aplastic anemia. However, each child may experience symptoms differently. Symptoms may include: Headache, Dizziness, Nausea, Shortness of breath, Bruising, Lack of energy or tiring easily (fatigue), Abnormal paleness or lack of color of the skin, Blood in stool, Nosebleeds, Bleeding gums, Fevers, Sinus tenderness, Enlarged liver or spleen, Oral thrush (white patches on a red, moist, swollen surface, occurring anywhere in the mouth). […] The symptoms of aplastic anemia may resemble other blood disorders or medical problems. Always consult your child’s doctor for a diagnosis.

• #19 Aplastic Anemia Symptoms | Aplastic Anemia and MDS International Foundation (AAMDSIF)

  https://www.aamds.org/aplastic-anemia/symptoms

  Aplastic anemia symptoms vary from person to person. Specific symptoms depend on which of your blood cell types are affected and how low your blood counts have fallen. […] A low red blood cell count is called anemia. If you have a low red blood cell count, you may: Feel a little tired or very tired, Feel less alert or have trouble concentrating, Have a loss of appetite or lose weight, Have paler-than-normal skin, Have trouble breathing, Have rapid heartbeat, Have difficulty exercising or climbing stairs. […] A low white blood cell count is called neutropenia. In general, a low white cell count lowers an aplastic anemia patient’s ability to fight bacterial infections. If you have a low white blood cell count, you may: Have repeated fevers and infections, Get bladder infections that make it painful to urinate or make you urinate more often, Get lung infections that cause coughing and difficulty breathing, Get mouth sores, Get sinus infections and a stuffy nose, Get skin infections. A fever in an aplastic anemia patient is potentially serious. A doctor should be notified if a fever occurs.

• #20 Aplastic anemia | Beacon Health System

  https://www.beaconhealthsystem.org/library/diseases-and-conditions/aplastic-anemia?content_id=CON-20212607

  Having aplastic anemia weakens your immune system, which leaves you more prone to infections. […] If you have aplastic anemia, see your healthcare professional at the first sign of infection, such as a fever. You don’t want the infection to get worse because it could prove life-threatening. If you have severe aplastic anemia, your doctor might prescribe antibiotics or antiviral medicines to help prevent infections.

• #21 What Are the Signs and Symptoms of Aplastic Anemia? | Hematology-Oncology Associates of CNY

  https://www.hoacny.com/patient-resources/blood-disorders/aplastic-anemia/what-are-signs-and-symptoms-aplastic-anemia

  Lower than normal numbers of red blood cells, white blood cells, and platelets cause most of the signs and symptoms of aplastic anemia. […] The most common symptom of a low red blood cell count is fatigue (tiredness). A low red blood cell count also can cause shortness of breath; dizziness, especially when standing up; headaches; coldness in your hands or feet; pale skin; and chest pain. […] White blood cells help fight infections. Signs and symptoms of a low white blood cell count include fevers, frequent infections that can be severe, and flu-like illnesses that linger. […] People who have low platelet counts tend to bruise and bleed easily, and the bleeding may be hard to stop. Common types of bleeding associated with a low platelet count include nosebleeds, bleeding gums, pinpoint red spots on the skin, and blood in the stool. Women also may have heavy menstrual bleeding.

• #22 Aplastic Anemia Symptoms | Aplastic Anemia and MDS International Foundation (AAMDSIF)

  https://www.aamds.org/aplastic-anemia/symptoms

  A low platelet count is called thrombocytopenia. If you have a low platelet count, you may: Bruise or bleed more easily, even from minor scrapes and bumps, Get heavier than normal menstrual periods, Get nose bleeds, Get tiny, flat red spots under your skin (petechiae) caused by bleeding, Have bleeding gums, especially after dental work or from brushing your teeth. If platelet counts are not too low, there may be no obvious symptoms. In rare cases, the number of platelets can get so low that dangerous internal bleeding occurs. […] Bleeding that will not stop is a medical emergency. An aplastic anemia patient needs to seek immediate medical help if they have bleeding that can’t be stopped by usual methods, such as applying pressure to the area.

• #23 Severe Aplastic Anemia – Leukemia / Bone Marrow Transplant Program

  https://www.leukemiabmtprogram.org/patients-support-givers/diseases-treatments/severe-aplastic-anemia/

  Platelets are cells that help the blood to clot. Some chemotherapy drugs can cause your bone marrow to make fewer platelets. If you have a very low platelet count, you may get symptoms such as: Bruises on the skin without an apparent injury, Bleeding from the gums or nose, Blood blisters in the mouth, Pinhead-sized red spots in the skin, especially on the lower legs and feet. These are called petechiae. […] Neutrophils are one of the types of white blood cells. These cells are important in protecting you from infection. Chemotherapy will temporarily affect your bone marrows ability to make neutrophils. A fever can be a sign of infection. If you have a fever when your neutrophils are low, we may need to act quickly to give you antibiotics to stop a potential infection from causing serious harm.

• #24 Aplastic Anemia – Together by St. Jude™

  https://together.stjude.org/en-us/conditions/blood-disorders/aplastic-anemia.html

  Low Platelets (thrombocytopenia) can cause small red or purple spots under the skin (petechiae), nosebleeds, bleeding gums, bleeding that lasts longer than normal, bruising on the skin or purplish areas on the skin, lips, or inside the mouth, blood in urine or stool, and heavy bleeding during menstrual periods. […] Without treatment, aplastic anemia is life-threatening. Complications include severe infections, bleeding, and organ failure due to anemia. With prompt diagnosis and treatment, the overall five-year survival rate is more than 90% for children with aplastic anemia.

• #25 Aplastic Anemia | Children’s Hospital of Philadelphia

  https://www.chop.edu/conditions-diseases/aplastic-anemia

  The symptoms of AA are caused by low blood cell counts and include: […] Anemia, which may lead to tiredness, pale skin, headaches and fast heart rate […] Shortness of breath […] Weight loss […] Increase in bruises with an unknown cause […] Spontaneous nose bleeds that are difficult to stop […] Bleeding under the skin, causing tiny, flat red spots (called petechiae) which most often occur on the trunk and lower legs.

• #26 Aplastic Anemia | UVA Health

  https://uvahealth.com/services/blood-disorders/aplastic-anemia

  Aplastic anemia Symptoms include: […] Symptoms of aplastic anemia include: Fatigue, Shortness of breath with activity, Weakness, Rapid heart rate, Pale skin, Easy bruising, Nosebleeds and bleeding gums, Lengthy bleeding from cuts, Skin rash, Fever, Shortened attention span. […] Aplastic anemia is a type of anemia caused by problems with bone marrow. It can range from mild to severe.

• #27 Aplastic Anemia Symptoms | Aplastic Anemia and MDS International Foundation (AAMDSIF)

  https://www.aamds.org/aplastic-anemia/symptoms

  A low platelet count is called thrombocytopenia. If you have a low platelet count, you may: Bruise or bleed more easily, even from minor scrapes and bumps, Get heavier than normal menstrual periods, Get nose bleeds, Get tiny, flat red spots under your skin (petechiae) caused by bleeding, Have bleeding gums, especially after dental work or from brushing your teeth. If platelet counts are not too low, there may be no obvious symptoms. In rare cases, the number of platelets can get so low that dangerous internal bleeding occurs. […] Bleeding that will not stop is a medical emergency. An aplastic anemia patient needs to seek immediate medical help if they have bleeding that can’t be stopped by usual methods, such as applying pressure to the area.

• #28 What Are the Signs and Symptoms of Aplastic Anemia? | Hematology-Oncology Associates of CNY

  https://www.hoacny.com/patient-resources/blood-disorders/aplastic-anemia/what-are-signs-and-symptoms-aplastic-anemia

  Aplastic anemia can cause signs and symptoms that aren’t directly related to low blood cell counts. Examples include nausea (feeling sick to your stomach) and skin rashes. […] If symptoms do occur, they may include shortness of breath, swelling or pain in the abdomen or swelling in the legs caused by blood clots, blood in the urine, headaches, jaundice (a yellowish color of the skin or whites of the eyes).

• #29 Aplastic Anemia – Causes, Symptoms, and Treatment Options | Medanta

  https://www.medanta.org/pillar/understanding-aplastic-anemia-causes-symptoms-and-treatment-options

  In some cases, aplastic anemia can cause a skin rash or other skin abnormalities due to the lack of proper blood circulation or the body’s immune response. […] Dizziness or vertigo can occur due to the reduced oxygen supply to the brain, a common consequence of low red blood cell levels. […] Headaches are another potential symptom of aplastic anemia, which develops due to insufficient oxygen or the buildup of toxins in the body due to impaired blood cell production. […] Individuals with aplastic anemia may experience fever, particularly if they have an underlying infection. This is because low white blood cell counts weaken their immune system. […] It’s essential to note that the symptoms of aplastic anemia can vary in severity and may not be present in all individuals. Some people may experience only mild symptoms, while others may experience more severe manifestations.

• #30 About aplastic anaemia | NHS inform

  https://www.nhsinform.scot/illnesses-and-conditions/blood-and-lymph/aplastic-anaemia/about-aplastic-anaemia/

  Symptoms of aplastic anaemia can vary in severity. They are caused by low blood counts, which affect red blood cells, white blood cells and platelets. […] Symptoms of aplastic anaemia can include: fatigue, shortness of breath, headaches, chest pains, bleeding, bruising, reoccurring severe infections. […] Some patients also report experiencing general symptoms like: brain fog, poor concentration. […] If you have aplastic anaemia and a low white blood count, you’re at a higher risk of severe infections. […] People with aplastic anaemia who have a low platelet count are also at a higher risk of bruising and bleeding.

• #31 Content – Health Encyclopedia – University of Rochester Medical Center

  https://www.urmc.rochester.edu/encyclopedia/content?ContentTypeID=90&ContentID=P02312

  Aplastic anemia is a serious condition in which the bone marrow doesnt make enough new blood cells. With fewer blood cells, a child with aplastic anemia has: […] The most common symptoms of aplastic anemia are below. […] Low levels of red blood cells can cause: Pale skin, Chest pain, Irregular heart beat, Enlarged heart. […] Low levels of white blood cells can cause: Fevers, Mouth sores, Infections. […] Low levels of platelets can cause: Easy bruising, Nosebleeds, Bleeding gums, Blood in the stool, Heavy bleeding with menstrual periods. […] Other symptoms can include: Nausea, Skin rashes. […] Some symptoms include tiredness, paleness, frequent infections, and easy bruising and bleeding.

• #32 What is Aplastic Anemia: Causes, Symptoms, Diagnosis, Treatment – Cura4U

  https://cura4u.com/blog/what-is-aplastic-anemia-causes-symptoms-diagnosis-treatment

  Patients with aplastic anemia usually experience an extremely low quantity of each of three blood cells found in the body. This is the first sign that points to the likelihood of the disease. Commonly, people are low on all three blood cells, but each blood cell has a different symptom. […] Symptoms of low red blood cell count are tiredness, dizziness, pale skin, headaches, shortness of breath, chest pain, and irregular heartbeat. Low white blood cell symptoms include infection. Symptoms of a low platelet count are nosebleeds, easy bruising, and bleeding. In light of any of these symptoms, a complete blood count test may be ordered. In addition, the doctor may order a biopsy of the bone marrow as well. […] Overall, the most common symptoms are fatigue, weakness, recurring infections, the appearance of small red dots under the skin and headaches.

• #33 Aplastic Anemia | Colorado Blood Cancer Institute

  https://bloodcancerinstitute.com/service/aplastic-anemia

  Aplastic anemia occurs when the bone marrow stops or slows down production of all three types of blood cells: red blood cells, white blood cells and platelets. […] A reduced number of red blood cells causes the hemoglobin to drop, while a reduced number of white blood cells reduces the ability to fight infections. A reduced number of platelets can lead to bleeding. […] Although individuals may experience symptoms differently, the most common symptoms of aplastic anemia include: […] Headache, dizziness, nausea […] Shortness of breath and lack of energy […] Bruising and pale skin […] Excessive bleeding (nosebleeds, blood in the stool, bleeding gums) […] Fever […] Sinus tenderness […] Enlarged liver or spleen. […] Aplastic anemia is classified as mild, moderate, or severe. Severe aplastic anemia is life threatening and may require immediate hospitalization and treatment. Moderate and mild aplastic anemia is still serious, but usually does not require hospitalization to treat.

• #34 Marrowforums.org: Aplastic Anemia

  http://www.marrowforums.org/aa.html

  Aplastic anemia can be mild, moderate, severe, or very severe. Moderate aplastic anemia (MAA) is the classification for those who have significantly reduced blood counts but not as reduced as occurs in severe or very severe aplastic anemia. […] Severe aplastic anemia (SAA) is defined by a bone marrow cellularity of less than 25% and at least two of the following: absolute neutrophil count (ANC) less than 500 per microliter, absolute reticulocyte count (ARC) less than 20 thousand per microliter, platelet count less than 20 thousand per microliter. […] Very severe aplastic anemia (VSAA) is defined by an ANC less than 200 per microliter.

• #35 Aplastic Anemia – Hematology and Oncology – Merck Manual Professional Edition

  https://www.merckmanuals.com/professional/hematology-and-oncology/anemias-caused-by-deficient-erythropoiesis/aplastic-anemia

  Aplastic anemia is suspected in patients, particularly young patients, with pancytopenia. Severe aplastic anemia is defined by a bone marrow with […] Very severe aplastic anemia is defined as absolute neutrophil count 9/L). […] Long-term relapse or clonal evolution to myeloid malignancy occurs in up to half of patients.

• #36 Marrowforums.org: Aplastic Anemia

  http://www.marrowforums.org/aa.html

  Aplastic anemia can be mild, moderate, severe, or very severe. Moderate aplastic anemia (MAA) is the classification for those who have significantly reduced blood counts but not as reduced as occurs in severe or very severe aplastic anemia. […] Severe aplastic anemia (SAA) is defined by a bone marrow cellularity of less than 25% and at least two of the following: absolute neutrophil count (ANC) less than 500 per microliter, absolute reticulocyte count (ARC) less than 20 thousand per microliter, platelet count less than 20 thousand per microliter. […] Very severe aplastic anemia (VSAA) is defined by an ANC less than 200 per microliter.

• #37 Aplastic anemia – Symptoms & causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/aplastic-anemia/symptoms-causes/syc-20355015

  Aplastic anemia can have no symptoms. When present, symptoms can include: […] Aplastic anemia can be short-lived, or it can become chronic. It can be serious and even fatal.

• #38 Aplastic Anemia: Symptoms, Causes & Treatment

  https://my.clevelandclinic.org/health/diseases/16747-aplastic-anemia

  Aplastic anemia symptoms usually develop over weeks and months, so you may not notice changes in your body right away. In some cases, people have immediate severe symptoms. If you do develop symptoms, they may include: Frequent viral infections that last longer than usual. Fatigue. Bleeding or bruising more easily. Feeling short of breath (dyspnea). Skin color that’s paler than usual. Dizziness. Headache. Fever. […] Some aplastic anemia symptoms mimic other, less serious illnesses. Having a cold or flu doesn’t mean you have aplastic anemia. You should talk to a healthcare provider if you’ve been sick for several weeks and you feel very tired all the time. […] People with aplastic anemia may have the following complications, some of which may be life-threatening: Anemia. Severe infections. Excessive bleeding. Arrhythmia or heart failure. Myelodysplastic syndrome.

• #39 Aplastic anemia Information | Mount Sinai – New York

  https://www.mountsinai.org/health-library/diseases-conditions/aplastic-anemia

  Aplastic anemia is a condition in which the bone marrow does not make enough blood cells. Bone marrow is the soft, tissue in the center of bones that is responsible for producing blood cells and platelets. […] Symptoms are due to the underproduction of red cells, white cells, and platelets. Symptoms may be severe from the start or gradually worsen over time as the disease progresses. […] Low red cell count (anemia) can cause: Fatigue, Pallor (paleness), Rapid heart rate, Shortness of breath with exercise, Weakness, Lightheadedness upon standing. […] Low white cell count (leukopenia) causes an increased risk for infection. […] Low platelet count (thrombocytopenia) can result in bleeding. Symptoms include: Bleeding gums, Easy bruising, Nose bleeds, Rash, small pinpoint red marks on the skin (petechiae), Frequent or severe infections (less common).

• #40 Aplastic anemia – Diagnosis & treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/aplastic-anemia/diagnosis-treatment/drc-20355020

  Blood tests. Normally, red blood cell, white blood cell and platelet levels stay within certain ranges. In aplastic anemia, all three of these blood cell levels are low. […] Severe aplastic anemia, in which your blood cell counts are extremely low, is life-threatening and requires immediate hospitalization. […] Although not a cure for aplastic anemia, blood transfusions can provide blood cells your bone marrow isn’t producing. This can help control bleeding and relieve symptoms. […] Having aplastic anemia weakens your immune system, which leaves you more prone to infections. […] If you have aplastic anemia, see your healthcare professional at the first sign of infection, such as a fever. You don’t want the infection to get worse because it could prove life-threatening. […] Aplastic anemia caused by radiation and chemotherapy treatments for cancer usually improves after those treatments stop. The same is true for most other drugs that can cause aplastic anemia. […] Pregnant women with aplastic anemia are treated with blood transfusions. For many women, pregnancy-related aplastic anemia improves once the pregnancy ends. If that doesn’t happen, treatment is still necessary.

• #41 Aplastic anemia – Wikipedia

  https://en.wikipedia.org/wiki/Aplastic_anemia

  Overall, the five-year survival rate is higher than 75% among recipients of bone marrow transplantation. […] Older people (who are generally too frail to undergo bone marrow transplants) and people who are unable to find a good bone marrow match have five-year survival rates of up to 35% when undergoing immune suppression. […] Relapses are common. Relapse following ATG/ciclosporin use can sometimes be treated with a repeated course of therapy. In addition, 10-15% of severe aplastic anemia cases evolve into myelodysplastic syndrome and leukemia. […] Milder disease may resolve on its own.

• #42 Aplastic anemia – Diagnosis & treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/aplastic-anemia/diagnosis-treatment/drc-20355020

  Blood tests. Normally, red blood cell, white blood cell and platelet levels stay within certain ranges. In aplastic anemia, all three of these blood cell levels are low. […] Severe aplastic anemia, in which your blood cell counts are extremely low, is life-threatening and requires immediate hospitalization. […] Although not a cure for aplastic anemia, blood transfusions can provide blood cells your bone marrow isn’t producing. This can help control bleeding and relieve symptoms. […] Having aplastic anemia weakens your immune system, which leaves you more prone to infections. […] If you have aplastic anemia, see your healthcare professional at the first sign of infection, such as a fever. You don’t want the infection to get worse because it could prove life-threatening. […] Aplastic anemia caused by radiation and chemotherapy treatments for cancer usually improves after those treatments stop. The same is true for most other drugs that can cause aplastic anemia. […] Pregnant women with aplastic anemia are treated with blood transfusions. For many women, pregnancy-related aplastic anemia improves once the pregnancy ends. If that doesn’t happen, treatment is still necessary.

• #43 Aplastic Anemia: Symptoms, Causes & Treatment

  https://my.clevelandclinic.org/health/diseases/16747-aplastic-anemia

  Aplastic anemia symptoms usually develop over weeks and months, so you may not notice changes in your body right away. In some cases, people have immediate severe symptoms. If you do develop symptoms, they may include: Frequent viral infections that last longer than usual. Fatigue. Bleeding or bruising more easily. Feeling short of breath (dyspnea). Skin color that’s paler than usual. Dizziness. Headache. Fever. […] Some aplastic anemia symptoms mimic other, less serious illnesses. Having a cold or flu doesn’t mean you have aplastic anemia. You should talk to a healthcare provider if you’ve been sick for several weeks and you feel very tired all the time. […] People with aplastic anemia may have the following complications, some of which may be life-threatening: Anemia. Severe infections. Excessive bleeding. Arrhythmia or heart failure. Myelodysplastic syndrome.

• #44 Anemia – Aplastic Anemia | NHLBI, NIH

  https://www.nhlbi.nih.gov/health/anemia/aplastic-anemia

  Symptoms of aplastic anemia include: […] Aplastic anemia can raise your risk of complications such as bleeding, leukemia, or other serious blood conditions. Without treatment, aplastic anemia can lead to serious medical conditions such as an irregular heartbeat and heart failure.

• #45 Aplastic Anemia | MedlinePlus

  https://medlineplus.gov/aplasticanemia.html

  Aplastic anemia can develop suddenly or slowly. It can be mild or severe. The symptoms of aplastic anemia can include: […] Aplastic anemia can cause other problems, including frequent infections and bleeding. It raises your risk of developing a serious blood disorder. […] If not treated, aplastic anemia can also lead to heart problems such as an arrhythmia (a problem with the rate or rhythm of your heartbeat), an enlarged heart, or heart failure.

• #46 Aplastic anemia – Wikipedia

  https://en.wikipedia.org/wiki/Aplastic_anemia

  Overall, the five-year survival rate is higher than 75% among recipients of bone marrow transplantation. […] Older people (who are generally too frail to undergo bone marrow transplants) and people who are unable to find a good bone marrow match have five-year survival rates of up to 35% when undergoing immune suppression. […] Relapses are common. Relapse following ATG/ciclosporin use can sometimes be treated with a repeated course of therapy. In addition, 10-15% of severe aplastic anemia cases evolve into myelodysplastic syndrome and leukemia. […] Milder disease may resolve on its own.

• #47 Is aplastic anemia cancer? Definition and more

  https://www.medicalnewstoday.com/articles/is-aplastic-anemia-cancer

  Aplastic anemia is a condition in which the bone marrow does not produce enough of at least two of the following: […] The symptoms of aplastic anemia may include: fatigue, recurring infections or infections that last for a long time, paler skin than usual, bruising and bleeding easily or without a clear cause, frequent nosebleeds or bleeding gums, shortness of breath while exercising or being active, heart palpitations, dizziness, headaches, a fast or irregular heartbeat, fever, weakness, a purpura rash. […] Aplastic anemia can increase a person’s risk of developing leukemia. […] Additionally, the symptoms of leukemia and aplastic anemia are similar, as both conditions affect the bone marrow and production of blood cells. […] Aplastic anemia is a condition that affects the bone marrow and reduces the number of blood cells it makes. It is not a form of cancer, though a person’s risk of developing leukemia increases when they have aplastic anemia.

• #48 Pediatric Anemia (aplastic) – Conditions and Treatments | Children’s National Hospital

  https://www.childrensnational.org/get-care/health-library/aplastic-anemia

  Low levels of platelets can cause: Easy bruising, Nosebleeds, Bleeding gums, Blood in the stool, Heavy bleeding with menstrual periods. […] Other symptoms can include: Nausea, Skin rashes. […] The symptoms of aplastic anemia may look like other blood disorders or medical problems. Always check with your child’s doctor for a diagnosis. […] Treatment will depend on your child’s symptoms, age, general health and how severe the condition is. Treatment for aplastic anemia also depends on the cause. For mild aplastic anemia, treatment may not be needed. Treatment may include: Blood transfusions, Platelet transfusions, Antibiotics, Hormones or other medicines (to stimulate the bone marrow to produce cells), Immunosuppressive medicine, Stem cell transplant. […] Without treatment, complications of aplastic anemia include: Medicine used to treat anemia may cause side effects, Problems with growth and development, Cancers, Heart failure, Uncontrolled bleeding, Severe infections.

• #49 Idiopathic Aplastic Anemia: Symptoms, Causes, and Treatment

  https://www.healthline.com/health/idiopathic-aplastic-anemia

  The life expectancy of idiopathic aplastic anemia depends on several factors, such as the severity of the condition and your age. However, receiving treatment is crucial for increasing your life expectancy. […] Research suggests that more than 7 out of 10 people are alive 5 years after receiving a bone marrow transplant for aplastic anemia, while most people who don’t receive treatment die within 1 year of experiencing complications.

• #50 Aplastic anemia – Wikipedia

  https://en.wikipedia.org/wiki/Aplastic_anemia

  Aplastic anemia Specialty Oncology, hematology Symptoms pale skin, fatigue, fast heart rate, rash, dizziness, headache, frequent or prolonged infections, nosebleeds, bleeding gums, prolonged bleeding from cuts, unexplained or easy bruising, hematoma […] Anemia may lead to fatigue, pale skin, severe bruising, and a fast heart rate. […] Low platelets are associated with an increased risk of bleeding, bruising, and petechiae, because of the inability of the blood to clot appropriately. Low white blood cells result in chronic infections and a higher incidence of infections. […] Untreated, severe aplastic anemia has a high risk of death. Modern treatment produces a five-year survival rate that exceeds 85%, with younger age associated with higher survival. […] Survival rates for stem cell transplants vary depending on the age and availability of a well-matched donor. They are better for patients who have donors that are matched siblings and worse for patients who receive their marrow from unrelated donors.

• #51 Aplastic Anemia – Together by St. Jude™

  https://together.stjude.org/en-us/conditions/blood-disorders/aplastic-anemia.html

  Low Platelets (thrombocytopenia) can cause small red or purple spots under the skin (petechiae), nosebleeds, bleeding gums, bleeding that lasts longer than normal, bruising on the skin or purplish areas on the skin, lips, or inside the mouth, blood in urine or stool, and heavy bleeding during menstrual periods. […] Without treatment, aplastic anemia is life-threatening. Complications include severe infections, bleeding, and organ failure due to anemia. With prompt diagnosis and treatment, the overall five-year survival rate is more than 90% for children with aplastic anemia.

• #52 Aplastic Anemia: Signs, Symptoms, Causes & Treatments

  https://resources.healthgrades.com/right-care/blood-conditions/aplastic-anemia

  When aplastic anemia is severe, hospital treatment is often necessary to prevent potentially fatal complications. […] Left untreated, aplastic anemia has a high fatality rate. About 70% of people will die within a year if they do not get treatment. […] Even with treatment, the disease was often fatal in the past. However, with today’s treatments, the survival rate is vastly better. Standard treatment with immunosuppressants or a stem cell transplant allows about 80% of aplastic anemia patients to recover.

• #53

  https://healthmatch.io/anemia/aplastic-anemia-life-expectancy

  Without treatment, most people with aplastic anemia will likely die within a year. […] With treatment for aplastic anemia, most people experience improvement in their symptoms. […] Without treatment, most people with aplastic anemia die within the first year of experiencing symptoms of the condition. People who receive treatment have a higher survival rate than those who don’t receive treatment. Those who undergo a bone marrow transplant may even recover fully. […] Aplastic anemia life expectancy can depend on several factors, including: Age of the patient, The underlying cause of the disease, The severity of the condition, How long it took to start treatment after symptoms were first noticed, Type of treatment. […] In general, children with aplastic anemia have a very good chance of long-term survival. More than 90% of children with this condition survive for at least five years.

• #54 Aplastic anemia – Wikipedia

  https://en.wikipedia.org/wiki/Aplastic_anemia

  Overall, the five-year survival rate is higher than 75% among recipients of bone marrow transplantation. […] Older people (who are generally too frail to undergo bone marrow transplants) and people who are unable to find a good bone marrow match have five-year survival rates of up to 35% when undergoing immune suppression. […] Relapses are common. Relapse following ATG/ciclosporin use can sometimes be treated with a repeated course of therapy. In addition, 10-15% of severe aplastic anemia cases evolve into myelodysplastic syndrome and leukemia. […] Milder disease may resolve on its own.

• #55 Severe Aplastic Anemia: Symptoms, Causes, and Treatment

  https://www.healthline.com/health/anemia/severe-aplastic-anemia

  Severe aplastic anemia symptoms […] People with severe aplastic anemia have low levels of: […] Most symptoms of aplastic anemia are related to low levels of these three types of blood cells. Potential symptoms include: […] The symptoms of aplastic anemia can be vague in the early stages but tend to get worse over time. […] Severe aplastic anemia may lead to rapid death if its untreated. […] More than 75% of people with aplastic anemia survive at least 5 years after receiving a bone marrow transplant from a suitable donor. […] With treatment, many people with severe aplastic anemia are now able to live for many years in remission.

• #56

  https://healthmatch.io/anemia/aplastic-anemia-life-expectancy

  Aplastic anemia diagnosis is not a death sentence. With the right approach to treatment, it’s possible to live a normal life for many years. […] With an early diagnosis and an appropriate treatment plan, there’s a good chance that you’ll be able to live a relatively normal life for many years. However, this condition can be fatal, especially if left untreated. […] If left untreated, aplastic anemia can lead to many serious complications, including death. However, with timely diagnosis and treatment, the aplastic anemia survival rate can be relatively high. Most studies have shown that most patients survive for at least five years in most age groups.

• #57 Aplastic Anemia – Together by St. Jude™

  https://together.stjude.org/en-us/conditions/blood-disorders/aplastic-anemia.html

  Aplastic anemia is a rare blood disorder that occurs when bone marrow does not make enough blood cells. It is a type of bone marrow failure. […] Aplastic anemia can develop at any age. It is a severe and life-threatening blood disorder. […] Symptoms are caused by low numbers of red blood cells, white blood cells, and platelets. Your child’s signs and symptoms depend on which type of blood cell is affected and the severity of their condition. […] Low red blood cells (anemia) can cause fatigue or feeling tired, pale skin, gums, or nail beds, headache, dizziness or feeling lightheaded, cold hands or feet, fast or irregular heart rate, and shortness of breath. […] Low white blood cells (leukopenia) and low neutrophils (neutropenia) can cause fever, more infections than normal, especially from bacteria or fungi, and mouth ulcers.

• #58 Aplastic Anemia

  https://encyclopedia.nm.org/library/testsprocedures/Gynecology/85,P00075

  Aplastic anemia is a rare and serious condition. It occurs when your bone marrow doesnt make enough red and white blood cells, and platelets. Having fewer red blood cells causes hemoglobin to drop. […] Aplastic anemia can occur at any age. But it’s more common among teens, young adults, and older adults. Your risk increases if you: […] Each persons symptoms may vary. Symptoms may include: Headache. Dizziness. Upset stomach (nausea). Shortness of breath. Bruising. Lack of energy or tiring easily (fatigue). Fast or irregular heart rate. Abnormal paleness or lack of color in the skin. Blood in stool. Nosebleeds. Bleeding gums. Fevers. Sore sinuses. Enlarged liver or spleen. White patches in the mouth (oral thrush). […] This condition can make you feel tired, raise your risk of infections, and make you bruise or bleed more easily. […] To treat low blood counts, early treatment involves easing symptoms.

• #59 Aplastic Anemia (for Parents) | Nemours KidsHealth

  https://kidshealth.org/en/parents/aplastic-anemia.html

  Symptoms of aplastic (ay-PLASS-tik) anemia can range from mild to very severe. […] Someone with anemia might: look pale, have fast breathing and a fast heart rate, be short of breath, be very tired. […] Too few white blood cells leads to many infections. […] Not enough platelets can cause: nosebleeds, bleeding from the gums, blood in the poop (stool), easy bruising, small red or purple spots on the skin called petechiae (peh-TEE-kee-eye), in girls, very heavy periods.

• #60 Aplastic Anemia in Children | Boston Children’s Hospital

  https://www.childrenshospital.org/conditions/aplastic-anemia

  Aplastic anemia occurs when the bone marrow produces too few platelets, leading to a decrease in hemoglobin and symptoms of fatigue. A reduced number of a major type of white blood cell important for defense against bacterial and fungal infections, called neutrophils, increases susceptibility to infection. Too few platelets leads to increased risk of bleeding or bruising. […] Each child may experience symptoms differently, but the most common symptoms of aplastic anemia are: Lack of energy or tiring easily, Pale skin, lips, and hands, or paleness under the eyelids, Shortness of breath, Fevers or infections bleeding, such as bruising, bleeding gums, nosebleeds, or blood in the stool, Irregular heartbeat, Dizziness or headache. […] It is important to understand that some symptoms of anemia may resemble those of other more common medical problems or other blood disorders. Because some of these symptoms can also point to other conditions, and because anemia itself can be a symptom of another medical problem, its important to have your child evaluated by a qualified medical professional for an accurate diagnosis and prompt treatment.

• #61 Aplastic Anemia in Children

  https://www.nationwidechildrens.org/conditions/health-library/aplastic-anemia-in-children

  Aplastic anemia occurs when the bone marrow produces too few of all types of blood cells: red cells, white cells, and platelets. A reduced number of red blood cells causes the red cell number and hemoglobin (a type of protein in the red blood cells that carries oxygen to the tissues of the body) to drop. A reduced number of white blood cells causes the patient to be susceptible to infection. A reduced number of platelets can cause the blood not to clot the way it should. […] The following are the most common symptoms of aplastic anemia. However, each child may experience symptoms differently. Symptoms may include: Headache, Dizziness, Nausea, Shortness of breath, Bruising, Lack of energy or tiring easily (fatigue), Abnormal paleness or lack of color of the skin, Blood in stool, Nosebleeds, Bleeding gums, Fevers, Sinus tenderness, Enlarged liver or spleen, Oral thrush (white patches on a red, moist, swollen surface, occurring anywhere in the mouth). […] The symptoms of aplastic anemia may resemble other blood disorders or medical problems. Always consult your child’s doctor for a diagnosis.

• #62 Aplastic Anemia – Seattle Children’s

  https://www.seattlechildrens.org/conditions/aplastic-anemia/

  Aplastic anemia can cause low levels of white blood cells, red blood cells or platelets. Most children with this disease have low levels of all 3 types of cells. […] Your child’s symptoms will depend on which cells are low and how low they are. Your child may: […] Have more infections and not get over them as quickly as other children. Low levels of white blood cells increase the risk of infection. […] Be tired, dizzy or short of breath. Without enough red blood cells (anemia), your child may have low energy or these other symptoms. […] Bruise or bleed easily because of low platelet levels. […] Some people with aplastic anemia do not notice any symptoms. They may learn about a problem after a routine blood test is done for another reason.

• #63 When Your Child Has Aplastic Anemia | Saint Luke’s Health System

  https://www.saintlukeskc.org/health-library/when-your-child-has-aplastic-anemia

  Some children have no symptoms. If symptoms are present, they may include […] Pale skin […] Crankiness […] Weakness […] Lack of energy (fatigue) […] Shortness of breath […] Trouble doing normal amounts of physical activity (exercise intolerance) […] Rapid heartbeat […] Dizziness or fainting […] Fever […] Recurrent or severe infections […] Excessive bruising or bleeding […] Ulcers in the mouth.

• #64 Aplastic anaemia | Great Ormond Street Hospital

  https://www.gosh.nhs.uk/conditions-and-treatments/conditions-we-treat/aplastic-anaemia/

  Aplastic anaemia is a serious condition affecting the blood, where the bone marrow and stem cells do not produce enough blood cells. […] In aplastic anaemia, all types of blood cells are reduced. This is called pancytopenia pan means all, cyto means cells and penia means few. […] The most common symptom of aplastic anaemia is bruising. A child may bruise easily often without having a fall or knock. This is caused by low numbers of platelets in the childs blood stream, which reduces the bloods ability to clot. […] Another symptom is anaemia, which is caused by a low red blood cell count. This means that oxygen is not getting to the muscles as normal, which can make the child lack energy and become tired more quickly. […] Neutropenia is another symptom of aplastic anaemia, and is the medical term for a low neutrophil count. This means the child may seem to catch more infections than normal or they last longer than in other children. The risk of infection depends on the neutrophil count. Neutropenia is diagnosed when the neutrophil count falls below 0.5 x 109/l.

• #65 Aplastic Anemia: Types, Symptoms, Causes & Treatment

  https://www.webmd.com/a-to-z-guides/aplastic-anemia

  Aplastic anemia symptoms may come on gradually or appear suddenly and severely. Your symptoms may vary depending on what types of blood cells you’re low on, but you may be low on all three. […] Symptoms of low red blood cell count include tiredness, shortness of breath, dizziness, pale skin, headaches, chest pain, and fast heartbeat. […] Symptoms of low white blood cell count include infections and fever. […] Symptoms of low platelet count include easy bruising and bleeding, and nosebleeds.

• #66 What is aplastic anemia? Symptoms, causes, and treatment

  https://www.medicalnewstoday.com/articles/326781

  Headaches, dizziness, and fatigue are common symptoms of aplastic anemia. […] Symptoms of aplastic anemia include: dizziness, easy bruising, fatigue, headache, irritability, lightheadedness, pale skin, problems breathing, weakness. […] These symptoms may be severe. Some people may have heart-related symptoms, such as chest pain.

• #67 Aplastic Anemia – Causes, Symptoms, and Treatment Options | Medanta

  https://www.medanta.org/pillar/understanding-aplastic-anemia-causes-symptoms-and-treatment-options

  Aplastic anemia can manifest with a range of symptoms. The severity of the condition and the specific blood cell types affected can influence its symptoms. The most common symptoms include: […] One of the most prominent manifestations of aplastic anemia is fatigue or extreme tiredness. This symptom is due to the lack of RBCs, which carry oxygen throughout the body. Without sufficient oxygen, individuals may feel weak, lethargic, and unable to perform daily activities. […] Shortness of breath, or dyspnea, is another common manifestation of aplastic anemia. As red blood cells decrease, the body struggles to transport enough oxygen to the lungs and other organs, leading to difficulty breathing, especially during physical exertion. […] The heart may beat faster or irregularly to compensate for the lack of oxygen in the bloodstream. It can also cause palpitations, dizziness, and lightheadedness.

• #68 Aplastic Anemia – Causes, Symptoms, and Treatment Options | Medanta

  https://www.medanta.org/pillar/understanding-aplastic-anemia-causes-symptoms-and-treatment-options

  Due to insufficient red blood cells, people with aplastic anemia may appear pale or have a yellowish tint to their skin, known as jaundice. […] A low white blood cell count (leukopenia) increases the likelihood of infections, as white blood cells are the body’s primary defense against pathogens. Individuals with aplastic anemia may experience frequent or prolonged infections, such as colds, flu, or other respiratory diseases. […] Platelets are vital for blood clotting, and a low platelet count (thrombocytopenia) can lead to easy bruising or the appearance of small reddish-purple spots on the skin, known as petechiae. […] People with aplastic anemia may experience frequent nosebleeds or bleeding gums due to the lack of platelets essential for proper blood clotting. […] Minor cuts, abrasions, or injuries may take longer to stop bleeding in individuals with aplastic anemia, as the lack of platelets impairs the body’s ability to form clots and stop bleeding effectively.

• #69 Severe Aplastic Anemia – Leukemia / Bone Marrow Transplant Program

  https://www.leukemiabmtprogram.org/patients-support-givers/diseases-treatments/severe-aplastic-anemia/

  Severe aplastic anemia (SAA) is a disorder of the blood and bone marrow. In SAA the immune system stops the bone marrow from producing blood cells normally. Individuals with SAA may not have any associated symptoms and therefore require no active treatment. Treatment may be necessary for patients, who are experiencing symptoms related to low blood cell levels and/or whose blood cell levels are clinically considered too low. […] The blood counts to which the nurses and doctors will refer are the hemoglobin, platelets, and neutrophils. […] Anemia is a condition in which you dont have enough healthy red blood cells to carry adequate oxygen to the bodys tissues. […] Some treatments can reduce your red blood cells and cause anemia. You may feel very tired, weak, dizzy or short of breath. You may notice that your skin, gums, and nails are pale. The symptoms will improve as your body produces more red blood cells.

• #70 Aplastic Anemia Signs & Symptoms | Rush

  https://www.rush.edu/conditions/aplastic-anemia

  Aplastic anemia can leave you feeling exhausted and increase your infection risk. […] Symptoms of Aplastic Anemia include fatigue, dizziness, shortness of breath (dyspnea), cold hands and feet, pale skin, headache, irregular heartbeat, frequent infections, fever and flu-like symptoms, bruising easily, nosebleeds, bleeding gums, bloody stool and other types of bleeding, which may be hard to stop, and heavy menstrual bleeding. […] If you experience any of the symptoms listed above, tell your primary care doctor. Your provider will examine you and order blood tests or imaging scans.

• #71 Aplastic Anemia: Symptoms, Causes & Treatment

  https://my.clevelandclinic.org/health/diseases/16747-aplastic-anemia

  Aplastic anemia symptoms usually develop over weeks and months, so you may not notice changes in your body right away. In some cases, people have immediate severe symptoms. If you do develop symptoms, they may include: Frequent viral infections that last longer than usual. Fatigue. Bleeding or bruising more easily. Feeling short of breath (dyspnea). Skin color that’s paler than usual. Dizziness. Headache. Fever. […] Some aplastic anemia symptoms mimic other, less serious illnesses. Having a cold or flu doesn’t mean you have aplastic anemia. You should talk to a healthcare provider if you’ve been sick for several weeks and you feel very tired all the time. […] People with aplastic anemia may have the following complications, some of which may be life-threatening: Anemia. Severe infections. Excessive bleeding. Arrhythmia or heart failure. Myelodysplastic syndrome.

• #72 Marrowforums.org: Aplastic Anemia

  http://www.marrowforums.org/aa.html

  Symptoms of a low white blood cell count include fevers, frequent infections that can be severe, and flu-like illnesses that linger. […] Symptoms of a low platelet count include the tendency to bruise and bleed easily and to have bleeding that may be hard to stop. Common types of bleeding include nosebleeds, bleeding gums, pinpoint red bleeding spots on the skin (petechiae), and blood in the stool. […] Because many of these symptoms can result from other conditions, a patient who experiences one or more symptoms of aplastic anemia does not necessarily have aplastic anemia. For the same reason, aplastic anemia may not be recognized or diagnosed at first. It is essential to consult a doctor for a professional diagnosis. […] The low blood counts and resulting symptoms experienced by aplastic anemia patients result from the lack of mature cells: anemia: insufficient red blood cells; neutropenia: insufficient white blood cells; thrombocytopenia: insufficient platelets.

• #73 Aplastic Anemia: Symptoms, Causes & Treatment

  https://my.clevelandclinic.org/health/diseases/16747-aplastic-anemia

  Aplastic anemia symptoms usually develop over weeks and months, so you may not notice changes in your body right away. In some cases, people have immediate severe symptoms. If you do develop symptoms, they may include: Frequent viral infections that last longer than usual. Fatigue. Bleeding or bruising more easily. Feeling short of breath (dyspnea). Skin color that’s paler than usual. Dizziness. Headache. Fever. […] Some aplastic anemia symptoms mimic other, less serious illnesses. Having a cold or flu doesn’t mean you have aplastic anemia. You should talk to a healthcare provider if you’ve been sick for several weeks and you feel very tired all the time. […] People with aplastic anemia may have the following complications, some of which may be life-threatening: Anemia. Severe infections. Excessive bleeding. Arrhythmia or heart failure. Myelodysplastic syndrome.

• #74 Aplastic Anemia Symptoms | Aplastic Anemia and MDS International Foundation (AAMDSIF)

  https://www.aamds.org/aplastic-anemia/symptoms

  Aplastic anemia symptoms vary from person to person. Specific symptoms depend on which of your blood cell types are affected and how low your blood counts have fallen. […] A low red blood cell count is called anemia. If you have a low red blood cell count, you may: Feel a little tired or very tired, Feel less alert or have trouble concentrating, Have a loss of appetite or lose weight, Have paler-than-normal skin, Have trouble breathing, Have rapid heartbeat, Have difficulty exercising or climbing stairs. […] A low white blood cell count is called neutropenia. In general, a low white cell count lowers an aplastic anemia patient’s ability to fight bacterial infections. If you have a low white blood cell count, you may: Have repeated fevers and infections, Get bladder infections that make it painful to urinate or make you urinate more often, Get lung infections that cause coughing and difficulty breathing, Get mouth sores, Get sinus infections and a stuffy nose, Get skin infections. A fever in an aplastic anemia patient is potentially serious. A doctor should be notified if a fever occurs.

• #75 Aplastic anemia | Beacon Health System

  https://www.beaconhealthsystem.org/library/diseases-and-conditions/aplastic-anemia?content_id=CON-20212607

  Having aplastic anemia weakens your immune system, which leaves you more prone to infections. […] If you have aplastic anemia, see your healthcare professional at the first sign of infection, such as a fever. You don’t want the infection to get worse because it could prove life-threatening. If you have severe aplastic anemia, your doctor might prescribe antibiotics or antiviral medicines to help prevent infections.

• #76 Aplastic Anemia Signs & Symptoms | Rush

  https://www.rush.edu/conditions/aplastic-anemia

  Aplastic anemia can leave you feeling exhausted and increase your infection risk. […] Symptoms of Aplastic Anemia include fatigue, dizziness, shortness of breath (dyspnea), cold hands and feet, pale skin, headache, irregular heartbeat, frequent infections, fever and flu-like symptoms, bruising easily, nosebleeds, bleeding gums, bloody stool and other types of bleeding, which may be hard to stop, and heavy menstrual bleeding. […] If you experience any of the symptoms listed above, tell your primary care doctor. Your provider will examine you and order blood tests or imaging scans.

• #77 Aplastic Anemia: Symptoms & Treatment | Baptist Cancer Center

  https://www.baptistcancercenter.com/Cancers-We-Treat/Aplastic-Anemia

  Aplastic anemia, or bone marrow aplasia, forms when the body does not produce enough new blood cells. People with aplastic anemia experience a higher risk of infection and uncontrolled bleeding, and they often feel fatigued. Though rare, aplastic anemia may occur suddenly or develop slowly and worsen over time. […] Symptoms of aplastic anemia can include: dizziness, frequent or prolonged infections, headache, nosebleeds and bleeding gums, pale skin, prolonged bleeding from cuts, rapid or irregular heart rate, shortness of breath with exertion, skin rash, unexplained or easy bruising. […] Your doctor may suspect aplastic anemia if the quantity of three blood cell types is much lower than normal. If you experience these symptoms, your doctor may order a complete blood count test or perform a biopsy of your bone marrow to check for aplastic anemia.

• #78 Aplastic Crisis: Causes, Symptoms & Treatment

  https://my.clevelandclinic.org/health/diseases/24557-aplastic-crisis

  Aplastic crisis happens when your bone marrow suddenly stops making red blood cells. Aplastic crises can be life-threatening because they cause severe anemia. Aplastic crisis symptoms include: Fatigue (extreme tiredness). Fever (temperature of 101 degrees Fahrenheit, or 38 degrees Celsius). Dizziness. Shortness of breath (dyspnea). Irregular or rapid heartbeat. Pallor (or lips, gums or fingernails that are paler than usual). […] Aplastic crisis is a medical emergency. If you have sickle cell anemia or a similar blood disorder, contact your healthcare provider right away if you notice sudden changes in your body such as suddenly feeling weak or feeling extremely tired. […] Prognosis is your expected outcome given your situation. People with aplastic crisis usually recover within 10 to 14 days after starting treatment. But some people may have recurring aplastic crises, or crises that keep on happening.

• #79 Aplastic Anemia | Conditions | UCSF Benioff Children’s Hospitals

  https://www.ucsfbenioffchildrens.org/conditions/aplastic-anemia

  Aplastic anemia is suspected when test results indicate that all three blood cell levels are extremely low, but the cells themselves have a relatively normal appearance. […] In addition to low blood cell counts, aplastic anemia is characterized by other physical symptoms of anemia such as pale skin and fingernails, rapid pulse, heart murmur and fatigue. Children also may exhibit abnormal bleeding including multiple bruises, nosebleeds, bleeding gums and small hemorrhages under the skin as well as infection, especially fever. However, each child may experience symptoms differently. Other possible symptoms include: […] Aplastic anemia usually depends on the underlying cause. For certain causes, recovery can be expected after treatment. However, relapses can occur. If all treatments fail, aplastic anemia can be fatal. […] To treat the low blood counts, initial treatment is supportive, meaning it is necessary to treat the symptoms but it doesn’t cure the disease.

• #80 Aplastic Anemia – Blood Disorders – Merck Manual Consumer Version

  https://www.merckmanuals.com/home/blood-disorders/anemia/aplastic-anemia

  Aplastic anemia is a disorder in which the cells of the bone marrow that develop into mature blood cells are destroyed, leading to low numbers of red blood cells, white blood cells, and/or platelets. […] Symptoms of aplastic anemia usually develop slowly over weeks to months. The anemia causes fatigue, weakness, and paleness. The leukopenia causes increased susceptibility to infection. The thrombocytopenia causes easy bruising and bleeding. […] Aplastic anemia is diagnosed when microscopic examination of a sample of bone marrow (bone marrow biopsy) reveals a sharp decrease in bone marrow cells.

• #81 Aplastic Anemia: Practice Essentials, Background, Etiology

  https://emedicine.medscape.com/article/198759-overview

  Aplastic anemia is a syndrome of bone marrow failure characterized by peripheral pancytopenia and marrow hypoplasia. The clinical presentation of patients with aplastic anemia includes signs and symptoms related to the decrease in bone marrow production of hematopoietic cells. The onset is insidious, and the initial clinical manifestation is frequently related to anemia or bleeding, although fever or infections may be noted at presentation. Signs and symptoms of aplastic anemia may include the following: Pallor, Headache, Palpitations, dyspnea, Fatigue, Foot swelling, Gingival bleeding, petechial rashes, Overt and/or recurrent infections, Oropharyngeal ulcerations. A subset of patients with aplastic anemia present with jaundice or other evidence of hepatitis. […] Severe or very severe aplastic anemia is a hematologic emergency, and care should be instituted promptly. The outcome of patients with aplastic anemia has substantially improved because of improved supportive care. The natural history of aplastic anemia suggests that a small number of patients may spontaneously recover with supportive care; however, observation and/or supportive care alone is rarely indicated. Specific therapies, including hematopoietic cell transplantation (HCT) and immunosuppressive regimens, can be curative, particularly in cases with an identical HLA family donor, where overall survival probability is as high as 90%.

• #82 Aplastic anemia – Diagnosis & treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/aplastic-anemia/diagnosis-treatment/drc-20355020

  Blood tests. Normally, red blood cell, white blood cell and platelet levels stay within certain ranges. In aplastic anemia, all three of these blood cell levels are low. […] Severe aplastic anemia, in which your blood cell counts are extremely low, is life-threatening and requires immediate hospitalization. […] Although not a cure for aplastic anemia, blood transfusions can provide blood cells your bone marrow isn’t producing. This can help control bleeding and relieve symptoms. […] Having aplastic anemia weakens your immune system, which leaves you more prone to infections. […] If you have aplastic anemia, see your healthcare professional at the first sign of infection, such as a fever. You don’t want the infection to get worse because it could prove life-threatening. […] Aplastic anemia caused by radiation and chemotherapy treatments for cancer usually improves after those treatments stop. The same is true for most other drugs that can cause aplastic anemia. […] Pregnant women with aplastic anemia are treated with blood transfusions. For many women, pregnancy-related aplastic anemia improves once the pregnancy ends. If that doesn’t happen, treatment is still necessary.

• #83 Aplastic Anemia Clinical Presentation: History, Physical Examination

  https://emedicine.medscape.com/article/198759-clinical

  The clinical presentation of patients with aplastic anemia includes symptoms related to the decrease in bone marrow production of hematopoietic cells. The onset is insidious, and the initial symptom is frequently related to anemia or bleeding, although fever or infections may be noted at presentation. Specific manifestations include the following: […] Anemia: May manifest as pallor, headache, palpitations, dyspnea, fatigue, or foot swelling […] Thrombocytopenia: May result in mucosal and gingival bleeding or petechial rashes […] Neutropenia: May manifest as overt infections, recurrent infections, or mouth and pharyngeal ulcerations. […] Physical examination may show signs of anemia (eg, pallor, tachycardia) and of thrombocytopenia (eg, petechiae, purpura, ecchymoses). Overt signs of infection are usually not apparent at diagnosis. A subset of patients with aplastic anemia present with jaundice and evidence of hepatitis.

• #84 Marrowforums.org: Aplastic Anemia

  http://www.marrowforums.org/aa.html

  Aplastic anemia can be mild, moderate, severe, or very severe. Moderate aplastic anemia (MAA) is the classification for those who have significantly reduced blood counts but not as reduced as occurs in severe or very severe aplastic anemia. […] Severe aplastic anemia (SAA) is defined by a bone marrow cellularity of less than 25% and at least two of the following: absolute neutrophil count (ANC) less than 500 per microliter, absolute reticulocyte count (ARC) less than 20 thousand per microliter, platelet count less than 20 thousand per microliter. […] Very severe aplastic anemia (VSAA) is defined by an ANC less than 200 per microliter.

• #85 Aplastic Anemia – Hematology and Oncology – Merck Manual Professional Edition

  https://www.merckmanuals.com/professional/hematology-and-oncology/anemias-caused-by-deficient-erythropoiesis/aplastic-anemia

  Aplastic anemia is suspected in patients, particularly young patients, with pancytopenia. Severe aplastic anemia is defined by a bone marrow with […] Very severe aplastic anemia is defined as absolute neutrophil count 9/L). […] Long-term relapse or clonal evolution to myeloid malignancy occurs in up to half of patients.

• #86 Aplastic Anemia in Children | Boston Children’s Hospital

  https://www.childrenshospital.org/conditions/aplastic-anemia

  Aplastic anemia occurs when the bone marrow produces too few platelets, leading to a decrease in hemoglobin and symptoms of fatigue. A reduced number of a major type of white blood cell important for defense against bacterial and fungal infections, called neutrophils, increases susceptibility to infection. Too few platelets leads to increased risk of bleeding or bruising. […] Each child may experience symptoms differently, but the most common symptoms of aplastic anemia are: Lack of energy or tiring easily, Pale skin, lips, and hands, or paleness under the eyelids, Shortness of breath, Fevers or infections bleeding, such as bruising, bleeding gums, nosebleeds, or blood in the stool, Irregular heartbeat, Dizziness or headache. […] It is important to understand that some symptoms of anemia may resemble those of other more common medical problems or other blood disorders. Because some of these symptoms can also point to other conditions, and because anemia itself can be a symptom of another medical problem, its important to have your child evaluated by a qualified medical professional for an accurate diagnosis and prompt treatment.

• #87 Aplastic anaemia – Leukaemia Foundation

  https://www.leukaemia.org.au/blood-cancer/types-of-blood-cancer/aplastic-anaemia/

  Aplastic anaemia is a rare disorder in which the bone marrow fails to produce enough blood cells. This happens because the normal blood forming cells (stem cells) are replaced by abnormal fat cells. […] Although aplastic anaemia is not a malignant disease (cancer) it can be very serious, especially if the bone marrow is severely affected and there are very few blood cells left in circulation. Without adequate numbers of blood cells people with aplastic anaemia can become anaemic (low red blood cells) and more susceptible to infections (low white blood cells), and to bleeding and bruising more easily (low platelets). […] The main symptoms of aplastic anaemia are caused by a lack of normal blood cells. Common symptoms include: anaemia due to a lack of red cells, causing persistent tiredness, dizziness, paleness, or shortness of breath when physically active; frequent or repeated infections and slow healing, due to a lack of normal white cells, especially neutrophils; increased or unexplained bleeding or bruising, due to a very low platelet count. […] Occasionally people have no symptoms at all and aplastic anaemia is diagnosed during a routine blood test. Some of these symptoms described may also be seen in other illnesses, including viral infections, so it is important to see your doctor so that you can be examined and treated properly.

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