Materiały źródłowe

• #1 Dementia Prevention and Treatment: A Narrative Review – PubMed

  https://pubmed.ncbi.nlm.nih.gov/38436963/

  Dementia affects 10% of those 65 years or older and 35% of those 90 years or older, often with profound cognitive, behavioral, and functional consequences. […] Preventive measures are aimed at modifiable risk factors, many of which have been identified. […] To date, no randomized clinical trial data conclusively confirm that interventions of any kind can prevent dementia. […] Nevertheless, addressing risk factors may have other health benefits and should be considered. […] Several emerging prevention and treatment strategies hold promise to improve dementia care in the future. […] Although current prevention and treatment approaches to dementia have been less than optimally successful, substantial investments in dementia research will undoubtedly provide new answers to reducing the burden of dementia worldwide.

• #2 Reducing Risk for Dementia | Alzheimer’s Disease and Dementia | CDC

  https://www.cdc.gov/alzheimers-dementia/prevention/index.html

  There are common conditions and lifestyle behaviors that can increase your risk for dementia. […] Learn what they are and the healthy lifestyle habits that can lower your risk of developing dementia, including Alzheimer’s disease. […] Nearly 45% of all dementia cases may be prevented or delayed. […] Small changes can make a big difference to lower your risk of dementia. […] Healthy habits can benefit brain health by: […] Reducing the chances of worsening memory loss. […] Slowing the progression of dementia, including Alzheimer’s. […] Regular physical activity can help you prevent, delay, or manage chronic diseases, like dementia. […] The good news is type 2 diabetes can be prevented or delayed. […] High blood pressure can damage blood vessels and limit blood flow to the brain, which does damage to the brain. […] Treating hearing loss (using hearing aids) may reduce the risk of dementia. […] If you drink alcohol, do so in moderation. […] Quit smoking to reduce your risk dementia. Quitting smoking also reduces other risks for dementia, like stroke, type 2 diabetes, and high blood pressure.

• #3 Nearly half of dementia cases could be prevented or delayed by tackling 14 risk factors | UCL News – UCL – University College London

  https://www.ucl.ac.uk/news/2024/jul/nearly-half-dementia-cases-could-be-prevented-or-delayed-tackling-14-risk-factors

  Addressing 14 modifiable risk factors, starting in childhood and continuing throughout life, could prevent or delay nearly half of dementia cases, according to a new report led by UCL researchers. […] The Commission, authored by 27 world-leading dementia experts, calls for governments and individuals to be ambitious about tackling risks across the life course for dementia, arguing that the earlier we can address and reduce risk factor levels, the better. The report outlines a new set of policy and lifestyle changes to help prevent and better manage dementia. […] To reduce dementia risk throughout life, the Commission outlines 13 recommendations to be adopted by governments and individuals, including: Provide all children with good quality education and be cognitively active in midlife.

• #4 Prevention | Alzheimer’s Drug Discovery Foundation

  https://www.alzdiscovery.org/research-and-grants/funding-opportunities/prevention-pipeline

  The ADDF seeks to support precision prevention studies, combination therapy studies, and comparative effectiveness research that probe whether the use or choice of interventions may reduce the risk of Alzheimers disease or other dementias. […] Primary Prevention studies include people without biomarker evidence of dementia pathology or dementia symptoms but who have specific risk factors for dementia. […] Secondary Prevention studies include people with biomarker evidence of dementia pathology who do not yet have dementia symptoms. […] In July 2024, the Lancet Commission on Dementia Prevention, Intervention and Care reported that 45% of dementia cases may be prevented by fully addressing 14 modifiable risk factors. […] Dementia risk reduction through Precision Prevention can be achieved with a targeted, mechanism-specific preventative intervention in specific populations who are at risk for developing dementia due to these risk factors and/or genetic risk factors, such as APOE4, as well as other medical conditions linked to dementia risk, including postoperative delirium/cognitive decline, menopause-related cognitive symptoms, chemotherapy-induced decline, and long COVID-19.

• #5 Nearly half of dementia cases could be prevented or delayed by tackling 14 risk factors | UCL News – UCL – University College London

  https://www.ucl.ac.uk/news/2024/jul/nearly-half-dementia-cases-could-be-prevented-or-delayed-tackling-14-risk-factors

  Addressing 14 modifiable risk factors, starting in childhood and continuing throughout life, could prevent or delay nearly half of dementia cases, according to a new report led by UCL researchers. […] The Commission, authored by 27 world-leading dementia experts, calls for governments and individuals to be ambitious about tackling risks across the life course for dementia, arguing that the earlier we can address and reduce risk factor levels, the better. The report outlines a new set of policy and lifestyle changes to help prevent and better manage dementia. […] To reduce dementia risk throughout life, the Commission outlines 13 recommendations to be adopted by governments and individuals, including: Provide all children with good quality education and be cognitively active in midlife.

• #6 PROMISING STRATEGIES FOR THE PREVENTION OF DEMENTIA

  https://pmc.ncbi.nlm.nih.gov/articles/PMC2762111/

  The incidence and prevalence of dementia is expected to increase several fold in the coming decades. Given that the current pharmaceutical treatment of dementia can only modestly improve symptoms, risk factor modification remains the cornerstone for dementia prevention. Some of the most promising strategies for the prevention of dementia include vascular risk factor control, cognitive activity, physical activity, social engagement, diet, and recognition of depression. […] Given the expected dramatic increase in the incidence and the prevalence of dementia, the identification of successful prevention and treatment strategies is critical. However, the current pharmaceutical treatment of dementia can only modestly improve symptoms and cannot cure or prevent dementia. As a result, prevention of dementia through risk factor identification and modification is of the utmost importance until disease modifying agents prove efficacious. If the onset of AD can be delayed by five years, the expected prevalence would decrease by more than 1 million cases after 10 years and more than 4 million cases after 50 years.

• #7 Reducing Risk for Dementia | Alzheimer’s Disease and Dementia | CDC

  https://www.cdc.gov/alzheimers-dementia/prevention/index.html

  There are common conditions and lifestyle behaviors that can increase your risk for dementia. […] Learn what they are and the healthy lifestyle habits that can lower your risk of developing dementia, including Alzheimer’s disease. […] Nearly 45% of all dementia cases may be prevented or delayed. […] Small changes can make a big difference to lower your risk of dementia. […] Healthy habits can benefit brain health by: […] Reducing the chances of worsening memory loss. […] Slowing the progression of dementia, including Alzheimer’s. […] Regular physical activity can help you prevent, delay, or manage chronic diseases, like dementia. […] The good news is type 2 diabetes can be prevented or delayed. […] High blood pressure can damage blood vessels and limit blood flow to the brain, which does damage to the brain. […] Treating hearing loss (using hearing aids) may reduce the risk of dementia. […] If you drink alcohol, do so in moderation. […] Quit smoking to reduce your risk dementia. Quitting smoking also reduces other risks for dementia, like stroke, type 2 diabetes, and high blood pressure.

• #8 Reduce your risk of dementia | Alzheimer’s Society

  https://www.alzheimers.org.uk/about-dementia/managing-the-risk-of-dementia/reduce-your-risk-of-dementia

  Social isolation can greatly increase a person’s risk of dementia. […] Certain health conditions, such as high blood pressure, high cholesterol or diabetes can increase the risk of getting dementia. […] Uncorrected vision loss increases a person’s risk of developing dementia. […] Hearing loss is related to an increased risk of developing dementia and may be an early symptom. […] Traumatic brain injuries are caused by a blow or jolt to the head especially when the person is knocked out unconscious. […] Certain forms of air pollution increase a person’s risk of dementia.

• #9 Reducing Risk for Dementia | Alzheimer’s Disease and Dementia | CDC

  https://www.cdc.gov/alzheimers-dementia/prevention/index.html

  There are common conditions and lifestyle behaviors that can increase your risk for dementia. […] Learn what they are and the healthy lifestyle habits that can lower your risk of developing dementia, including Alzheimer’s disease. […] Nearly 45% of all dementia cases may be prevented or delayed. […] Small changes can make a big difference to lower your risk of dementia. […] Healthy habits can benefit brain health by: […] Reducing the chances of worsening memory loss. […] Slowing the progression of dementia, including Alzheimer’s. […] Regular physical activity can help you prevent, delay, or manage chronic diseases, like dementia. […] The good news is type 2 diabetes can be prevented or delayed. […] High blood pressure can damage blood vessels and limit blood flow to the brain, which does damage to the brain. […] Treating hearing loss (using hearing aids) may reduce the risk of dementia. […] If you drink alcohol, do so in moderation. […] Quit smoking to reduce your risk dementia. Quitting smoking also reduces other risks for dementia, like stroke, type 2 diabetes, and high blood pressure.

• #10 Can dementia be prevented – NHS

  https://www.nhs.uk/conditions/dementia/about-dementia/prevention/

  There’s no certain way to prevent all types of dementia, as researchers are still investigating how the condition develops. […] However, there’s good evidence that a healthy lifestyle can help reduce your risk of developing dementia when you’re older. […] The research concluded that by modifying the risk factors we are able to change, around 4 in 10 cases of dementia could be prevented. […] Experts agree that what’s good for your heart is also good for your brain. This means you can help reduce your risk of dementia by: eating a balanced diet, maintaining a healthy weight, exercising regularly, keeping alcohol within recommended limits, stopping smoking, keeping your blood pressure at a healthy level. […] If you are overweight or living with obesity, even losing 5% to 10% of the excess weight can help reduce your risk of dementia.

• #11 Reduce your risk of dementia | Alzheimer’s Society

  https://www.alzheimers.org.uk/about-dementia/managing-the-risk-of-dementia/reduce-your-risk-of-dementia

  There are things you can do to reduce your own risk of developing dementia. These include keeping active, eating healthily and exercising your mind. […] There is a lot of evidence that lifestyle choices can affect our risk of developing dementia. Dementia risk is lowest in people who have healthy behaviours in mid-life (aged 40-65). No single behaviour is guaranteed to prevent dementia, and some are more easy to change than others. […] Doing regular physical activity is one of the best ways to reduce your risk of dementia. […] Drinking too much alcohol increases your risk of developing dementia. […] If you smoke, you’re putting yourself at a much higher risk of developing dementia later in life. […] People who have had periods of depression in their life also have a higher risk of developing dementia.

• #12 Reduce your risk of dementia | Alzheimer’s Society

  https://www.alzheimers.org.uk/about-dementia/managing-the-risk-of-dementia/reduce-your-risk-of-dementia

  There are things you can do to reduce your own risk of developing dementia. These include keeping active, eating healthily and exercising your mind. […] There is a lot of evidence that lifestyle choices can affect our risk of developing dementia. Dementia risk is lowest in people who have healthy behaviours in mid-life (aged 40-65). No single behaviour is guaranteed to prevent dementia, and some are more easy to change than others. […] Doing regular physical activity is one of the best ways to reduce your risk of dementia. […] Drinking too much alcohol increases your risk of developing dementia. […] If you smoke, you’re putting yourself at a much higher risk of developing dementia later in life. […] People who have had periods of depression in their life also have a higher risk of developing dementia.

• #13 Reduce your risk of dementia | Alzheimer’s Society

  https://www.alzheimers.org.uk/about-dementia/managing-the-risk-of-dementia/reduce-your-risk-of-dementia

  Social isolation can greatly increase a person’s risk of dementia. […] Certain health conditions, such as high blood pressure, high cholesterol or diabetes can increase the risk of getting dementia. […] Uncorrected vision loss increases a person’s risk of developing dementia. […] Hearing loss is related to an increased risk of developing dementia and may be an early symptom. […] Traumatic brain injuries are caused by a blow or jolt to the head especially when the person is knocked out unconscious. […] Certain forms of air pollution increase a person’s risk of dementia.

• #14 Reducing Risk for Dementia | Alzheimer’s Disease and Dementia | CDC

  https://www.cdc.gov/alzheimers-dementia/prevention/index.html

  There are common conditions and lifestyle behaviors that can increase your risk for dementia. […] Learn what they are and the healthy lifestyle habits that can lower your risk of developing dementia, including Alzheimer’s disease. […] Nearly 45% of all dementia cases may be prevented or delayed. […] Small changes can make a big difference to lower your risk of dementia. […] Healthy habits can benefit brain health by: […] Reducing the chances of worsening memory loss. […] Slowing the progression of dementia, including Alzheimer’s. […] Regular physical activity can help you prevent, delay, or manage chronic diseases, like dementia. […] The good news is type 2 diabetes can be prevented or delayed. […] High blood pressure can damage blood vessels and limit blood flow to the brain, which does damage to the brain. […] Treating hearing loss (using hearing aids) may reduce the risk of dementia. […] If you drink alcohol, do so in moderation. […] Quit smoking to reduce your risk dementia. Quitting smoking also reduces other risks for dementia, like stroke, type 2 diabetes, and high blood pressure.

• #15 Reducing Risk for Dementia | Alzheimer’s Disease and Dementia | CDC

  https://www.cdc.gov/alzheimers-dementia/prevention/index.html

  There are common conditions and lifestyle behaviors that can increase your risk for dementia. […] Learn what they are and the healthy lifestyle habits that can lower your risk of developing dementia, including Alzheimer’s disease. […] Nearly 45% of all dementia cases may be prevented or delayed. […] Small changes can make a big difference to lower your risk of dementia. […] Healthy habits can benefit brain health by: […] Reducing the chances of worsening memory loss. […] Slowing the progression of dementia, including Alzheimer’s. […] Regular physical activity can help you prevent, delay, or manage chronic diseases, like dementia. […] The good news is type 2 diabetes can be prevented or delayed. […] High blood pressure can damage blood vessels and limit blood flow to the brain, which does damage to the brain. […] Treating hearing loss (using hearing aids) may reduce the risk of dementia. […] If you drink alcohol, do so in moderation. […] Quit smoking to reduce your risk dementia. Quitting smoking also reduces other risks for dementia, like stroke, type 2 diabetes, and high blood pressure.

• #16 Reduce your risk of dementia | Alzheimer’s Society

  https://www.alzheimers.org.uk/about-dementia/managing-the-risk-of-dementia/reduce-your-risk-of-dementia

  Social isolation can greatly increase a person’s risk of dementia. […] Certain health conditions, such as high blood pressure, high cholesterol or diabetes can increase the risk of getting dementia. […] Uncorrected vision loss increases a person’s risk of developing dementia. […] Hearing loss is related to an increased risk of developing dementia and may be an early symptom. […] Traumatic brain injuries are caused by a blow or jolt to the head especially when the person is knocked out unconscious. […] Certain forms of air pollution increase a person’s risk of dementia.

• #17 Targeting 14 lifestyle factors may prevent up to 45% of dementia cases | Cognitive Vitality | Alzheimer’s Drug Discovery Foundation

  https://www.alzdiscovery.org/cognitive-vitality/blog/targeting-14-lifestyle-factors-may-prevent-up-to-45-of-dementia-cases

  Targeting 14 lifestyle factors may prevent up to 45% of dementia cases. […] In July 2024, the Lancet Commission added two new risk factors and reported that 45% of dementia cases could be prevented by fully addressing 14 lifestyle factors. […] Not completing secondary education increases your risk of dementia. […] Lifelong learning is associated with improved brain health, and higher levels of cognitive activity at mid- or late-life are linked to delayed onset of cognitive impairment. […] Many high-quality observational studies suggest an association between hearing loss and subsequent dementia. […] Studies have found that with every 10-dB decrease in hearing ability, there is a 4 to 24% higher risk of dementia. […] High LDL cholesterol in midlife is associated with a higher risk of dementia.

• #18 Nearly half of dementia cases could be prevented or delayed by tackling 14 risk factors | UCL News – UCL – University College London

  https://www.ucl.ac.uk/news/2024/jul/nearly-half-dementia-cases-could-be-prevented-or-delayed-tackling-14-risk-factors

  Healthy lifestyles that involve regular exercise, not smoking, cognitive activity in midlife (including outside formal education) and avoiding excess alcohol can not only lower dementia risk but may also push back dementia onset. […] Prioritising population-level approaches that improve primary prevention (eg, reducing salt and sugar intake) and effective health care for conditions like obesity and high blood pressure, restricting smoking and air pollution, and enabling all children to gain a good education, could have a profound effect on dementia prevalence and inequalities, as well as significant cost savings. […] The authors stress that in many countries, effective interventions known to benefit people with dementia are still not available or a priority, including activity interventions that provide enjoyment and reduce neuropsychiatric symptoms and cholinesterase inhibitors for slowing cognitive decline in Alzheimers.

• #19 Targeting 14 lifestyle factors may prevent up to 45% of dementia cases | Cognitive Vitality | Alzheimer’s Drug Discovery Foundation

  https://www.alzdiscovery.org/cognitive-vitality/blog/targeting-14-lifestyle-factors-may-prevent-up-to-45-of-dementia-cases

  Studies suggest that having hypertension in midlife increases the risk of both vascular dementia and Alzheimer’s disease. […] People who are obese in midlife have an increased risk of dementia compared to those with healthy body weight. […] Heavy drinking is associated with cognitive impairment and dementia. […] Social isolation is a risk factor not only for dementia but also for hypertension, coronary heart disease, and depression. […] Many studies show that air pollution is a risk factor for dementia and cognitive impairment. […] An analysis of numerous cohort studies reported that vision impairment is associated with a higher risk of both dementia and cognitive impairment. […] The Lancet report is great news in that there are concrete steps you can take to reduce dementia risk. […] These recommendations are consistent with evidence from a seminal randomized controlled trial called FINGER that showed a group of lifestyle interventions that addressed many of these risk factors improved cognitive function in older people.

• #20 Nearly half of dementia cases could be prevented or delayed by tackling 14 risk factors | UCL News – UCL – University College London

  https://www.ucl.ac.uk/news/2024/jul/nearly-half-dementia-cases-could-be-prevented-or-delayed-tackling-14-risk-factors

  Healthy lifestyles that involve regular exercise, not smoking, cognitive activity in midlife (including outside formal education) and avoiding excess alcohol can not only lower dementia risk but may also push back dementia onset. […] Prioritising population-level approaches that improve primary prevention (eg, reducing salt and sugar intake) and effective health care for conditions like obesity and high blood pressure, restricting smoking and air pollution, and enabling all children to gain a good education, could have a profound effect on dementia prevalence and inequalities, as well as significant cost savings. […] The authors stress that in many countries, effective interventions known to benefit people with dementia are still not available or a priority, including activity interventions that provide enjoyment and reduce neuropsychiatric symptoms and cholinesterase inhibitors for slowing cognitive decline in Alzheimers.

• #21 Reduce your risk of dementia | Alzheimer’s Society

  https://www.alzheimers.org.uk/about-dementia/managing-the-risk-of-dementia/reduce-your-risk-of-dementia

  Social isolation can greatly increase a person’s risk of dementia. […] Certain health conditions, such as high blood pressure, high cholesterol or diabetes can increase the risk of getting dementia. […] Uncorrected vision loss increases a person’s risk of developing dementia. […] Hearing loss is related to an increased risk of developing dementia and may be an early symptom. […] Traumatic brain injuries are caused by a blow or jolt to the head especially when the person is knocked out unconscious. […] Certain forms of air pollution increase a person’s risk of dementia.

• #22 Reduce your risk of dementia | Alzheimer’s Society

  https://www.alzheimers.org.uk/about-dementia/managing-the-risk-of-dementia/reduce-your-risk-of-dementia

  Social isolation can greatly increase a person’s risk of dementia. […] Certain health conditions, such as high blood pressure, high cholesterol or diabetes can increase the risk of getting dementia. […] Uncorrected vision loss increases a person’s risk of developing dementia. […] Hearing loss is related to an increased risk of developing dementia and may be an early symptom. […] Traumatic brain injuries are caused by a blow or jolt to the head especially when the person is knocked out unconscious. […] Certain forms of air pollution increase a person’s risk of dementia.

• #23 Reduce your risk of dementia | Alzheimer’s Society

  https://www.alzheimers.org.uk/about-dementia/managing-the-risk-of-dementia/reduce-your-risk-of-dementia

  There are things you can do to reduce your own risk of developing dementia. These include keeping active, eating healthily and exercising your mind. […] There is a lot of evidence that lifestyle choices can affect our risk of developing dementia. Dementia risk is lowest in people who have healthy behaviours in mid-life (aged 40-65). No single behaviour is guaranteed to prevent dementia, and some are more easy to change than others. […] Doing regular physical activity is one of the best ways to reduce your risk of dementia. […] Drinking too much alcohol increases your risk of developing dementia. […] If you smoke, you’re putting yourself at a much higher risk of developing dementia later in life. […] People who have had periods of depression in their life also have a higher risk of developing dementia.

• #24 Prevention of dementia – UpToDate

  https://www.uptodate.com/contents/prevention-of-dementia/print

  Prevention of dementia […] While the overall evidence is generally of low quality and does not support any single intervention as effective in delaying or preventing dementia, there is optimism that intensive risk factor modification, especially during midlife (age 45 to 65 years), has the potential to delay or prevent a substantial number of dementia cases worldwide […] Based on epidemiologic evidence and biologic plausibility regarding the relationship between a healthy lifestyle and dementia risk (as well as other health benefits), we encourage patients to maintain or increase physical activity, exercise, cognitive leisure activities, and social interaction. […] Observational evidence supports an inverse association between various components of a healthy lifestyle (eg, social interaction, education and mental activities, physical exercise) and the incidence of dementia, even after adjusting for relevant confounders.

• #25 Alzheimer’s Association International Conference

  https://www.healio.com/news/psychiatry/20240731/eliminating-14-risk-factors-may-prevent-nearly-half-of-dementia-cases

  Eliminating these 14 risk factors may prevent nearly half of dementia cases. Tackling 14 risk factors for dementia beginning in childhood could prevent or delay nearly half of cases worldwide, according to a report from the Lancet Commission presented at the Alzheimer’s Association International Conference. These include two risk factors high cholesterol and vision loss newly identified by the commission on dementia prevention, intervention and care. If these 14 risk factors are eliminated, nearly half of dementias could theoretically be prevented, Livingston and colleagues wrote. Based on their findings, the researchers outlined 13 recommendations for individuals and governments to prevent dementia: ensure children have access to good-quality education and encourage individuals in midlife to participate in cognitively stimulating activities; reduce harmful noise exposure and make hearing aids accessible to those with hearing impairment; treat depression; promote helmets and other head protection during contact sports and when riding bicycles; encourage exercise; reduce smoking through education and by implementing policies that aim to control the cost of cigarettes; prevent or reduce high blood pressure; diagnose and treat high LDL; maintain a healthy weight and treat obesity early; reduce excessive alcohol use through price control and raising awareness about the risks of overconsumption; reduce social isolation by encouraging activities and living with other people, prioritizing an age-friendly and supportive community, environments and housing; ensure access to vision loss screening and treatment; and decrease air pollution exposure. Although addressing risk factors at an early stage of life is desirable, there is also benefit from tackling risk throughout life; it is never too early or too late to reduce dementia risk, Livingston and colleagues wrote.

• #26 Reduce your risk of dementia | Alzheimer’s Society

  https://www.alzheimers.org.uk/about-dementia/managing-the-risk-of-dementia/reduce-your-risk-of-dementia

  There are things you can do to reduce your own risk of developing dementia. These include keeping active, eating healthily and exercising your mind. […] There is a lot of evidence that lifestyle choices can affect our risk of developing dementia. Dementia risk is lowest in people who have healthy behaviours in mid-life (aged 40-65). No single behaviour is guaranteed to prevent dementia, and some are more easy to change than others. […] Doing regular physical activity is one of the best ways to reduce your risk of dementia. […] Drinking too much alcohol increases your risk of developing dementia. […] If you smoke, you’re putting yourself at a much higher risk of developing dementia later in life. […] People who have had periods of depression in their life also have a higher risk of developing dementia.

• #27 Physical activity and the risk of dementia | Alzheimer’s Society

  https://www.alzheimers.org.uk/about-dementia/managing-the-risk-of-dementia/reduce-your-risk-of-dementia/physical-activity

  Regular physical activity is one of the best things that you can do to reduce your risk of developing dementia. […] A lack of physical exercise is one of the main factors where the evidence is strong enough to show that it increases a persons risk of developing dementia. […] A lifelong approach to good health is the best way to lower your risk of dementia. […] There are some lifestyle behaviours with enough evidence to show that changing them will reduce your risk of dementia. […] Research has shown that people who take regular exercise may be up to 20% less likely to develop dementia than those who don’t take regular exercise. […] Sustaining physical activity throughout midlife also seems to have the best effect on reducing dementia risk. […] There is some evidence to show older people can also reduce their risk of dementia with regular exercise.

• #28 Physical activity and the risk of dementia | Alzheimer’s Society

  https://www.alzheimers.org.uk/about-dementia/managing-the-risk-of-dementia/reduce-your-risk-of-dementia/physical-activity

  Regular physical activity is one of the best things that you can do to reduce your risk of developing dementia. […] A lack of physical exercise is one of the main factors where the evidence is strong enough to show that it increases a persons risk of developing dementia. […] A lifelong approach to good health is the best way to lower your risk of dementia. […] There are some lifestyle behaviours with enough evidence to show that changing them will reduce your risk of dementia. […] Research has shown that people who take regular exercise may be up to 20% less likely to develop dementia than those who don’t take regular exercise. […] Sustaining physical activity throughout midlife also seems to have the best effect on reducing dementia risk. […] There is some evidence to show older people can also reduce their risk of dementia with regular exercise.

• #29 Dementia Insights: Primary Prevention of Dementia

  https://practicalneurology.com/articles/2020-oct/dementia-insights-primary-prevention-of-dementia

  Behavioral counseling to promote a healthy diet and physical activity is recommended for adults who are overweight or obese and also have cardiovascular risk factors. […] Physical activity promotes recovery after ischemic insult, and neuronal survival after neurotoxic injury in animal models. […] The World Health Organization recommends 150 minutes of moderate-intensity or 75 minutes of vigorous-intensity aerobic activity per week for adults ages 18 to 64 and suggests additional benefits from doubling the weekly duration of activity. […] A systematic review of 19 randomized clinical trials concluded there is encouraging but inconclusive evidence that physical activity may delay or slow age-related cognitive decline and insufficient evidence of whether physical activity prevents or delays clinical Alzheimer-type dementia.

• #30 Can Alzheimer’s Be Prevented? | Alzheimer’s Association

  https://www.alz.org/alzheimers-dementia/research-and-progress/prevention

  Researchers around the globe are exploring how to prevent Alzheimer’s. While Alzheimer’s prevention has no definitive answers at this time, research has shown that we can take action to reduce our risk of developing it. […] Though research is still evolving, evidence is strong that people can reduce their risk by making key lifestyle changes, including participating in regular activity and maintaining good heart health. Based on this research, the Alzheimer’s Association offers 10 Healthy Habits for Your Brain a collection of tips that can reduce the risk of cognitive decline. […] Regular physical exercise may be a beneficial strategy to lower the risk of Alzheimer’s and vascular dementia. Exercise may directly benefit brain cells by increasing blood and oxygen flow in the brain. Because of its known cardiovascular benefits, a medically approved exercise program is a valuable part of any overall wellness plan.

• #31 How to lower your dementia risk – Harvard Health

  https://www.health.harvard.edu/mind-and-mood/how-to-lower-your-dementia-risk

  „The most convincing evidence continues to be for the boring stuff aerobic exercise, a brain-healthy diet, and quality sleep,” says neuroscientist Dr. Daniel Daneshvar, chief of the division of brain injury rehabilitation with Harvard-affiliated Massachusetts General Hospital. „Even people with a family history of dementia could lower the risk by investing more in these basic healthy lifestyle habits.” Here’s how they help with dementia prevention. […] Aerobic exercise increases blood flow to the brain, supporting blood vessels and decreasing the risk of blood vessel damage. It also helps reduce inflammation, thought to be one of the main causes of abnormal protein buildup. […] There are several extensively studied diets that promote brain health, like the Mediterranean, DASH (Dietary Approaches to Stop Hypertension), and MIND (Mediterranean-DASH Intervention for Neurodegenerative Delay) diets. „These diets are linked to lower levels of brain-damaging chronic inflammation by reducing or eliminating red meat and processed foods and increasing the intake of antioxidant-rich fruits and vegetables and fatty fish high in omega-3 fatty acids,” says Dr. Daneshvar.

• #32 How to lower your dementia risk – Harvard Health

  https://www.health.harvard.edu/mind-and-mood/how-to-lower-your-dementia-risk

  „The most convincing evidence continues to be for the boring stuff aerobic exercise, a brain-healthy diet, and quality sleep,” says neuroscientist Dr. Daniel Daneshvar, chief of the division of brain injury rehabilitation with Harvard-affiliated Massachusetts General Hospital. „Even people with a family history of dementia could lower the risk by investing more in these basic healthy lifestyle habits.” Here’s how they help with dementia prevention. […] Aerobic exercise increases blood flow to the brain, supporting blood vessels and decreasing the risk of blood vessel damage. It also helps reduce inflammation, thought to be one of the main causes of abnormal protein buildup. […] There are several extensively studied diets that promote brain health, like the Mediterranean, DASH (Dietary Approaches to Stop Hypertension), and MIND (Mediterranean-DASH Intervention for Neurodegenerative Delay) diets. „These diets are linked to lower levels of brain-damaging chronic inflammation by reducing or eliminating red meat and processed foods and increasing the intake of antioxidant-rich fruits and vegetables and fatty fish high in omega-3 fatty acids,” says Dr. Daneshvar.

• #33

  https://journals.publishing.umich.edu/ujph/article/id/3946/

  Modifiable risk factors cause about a third of Alzheimers cases worldwide, demonstrating that risk factor reduction can aid in Alzheimers prevention. […] One lifestyle risk factor reduction strategy is regular physical activity due to its increase of neuroplasticity and high-density lipoprotein (HDL) cholesterol, as well as its reduction of inflammation and plaque formation. […] Another lifestyle risk factor reduction strategy is adherence to the MIND Diet for Neurodegenerative Delay, a combination of the Mediterranean diet and the Dietary Approaches to Stop Hypertension (DASH) diet. […] The 2020 Lancet Commission on Dementia Prevention describes population-based interventions and individually targeted interventions for Alzheimers primary prevention. […] Preventive interventions must address racial and ethnic disparities in Alzheimers risk that occur due to the following socioeconomic factors: low household income, low education attainment, and low literacy level.

• #34

  https://journals.publishing.umich.edu/ujph/article/id/3946/

  Modifiable risk factors cause about a third of Alzheimers cases worldwide, demonstrating that risk factor reduction can aid in Alzheimers prevention. […] One lifestyle risk factor reduction strategy is regular physical activity due to its increase of neuroplasticity and high-density lipoprotein (HDL) cholesterol, as well as its reduction of inflammation and plaque formation. […] Another lifestyle risk factor reduction strategy is adherence to the MIND Diet for Neurodegenerative Delay, a combination of the Mediterranean diet and the Dietary Approaches to Stop Hypertension (DASH) diet. […] The 2020 Lancet Commission on Dementia Prevention describes population-based interventions and individually targeted interventions for Alzheimers primary prevention. […] Preventive interventions must address racial and ethnic disparities in Alzheimers risk that occur due to the following socioeconomic factors: low household income, low education attainment, and low literacy level.

• #35

  https://journals.publishing.umich.edu/ujph/article/id/3946/

  Modifiable risk factors cause about a third of Alzheimers cases worldwide, demonstrating that risk factor reduction can aid in Alzheimers prevention. […] One lifestyle risk factor reduction strategy is regular physical activity due to its increase of neuroplasticity and high-density lipoprotein (HDL) cholesterol, as well as its reduction of inflammation and plaque formation. […] Another lifestyle risk factor reduction strategy is adherence to the MIND Diet for Neurodegenerative Delay, a combination of the Mediterranean diet and the Dietary Approaches to Stop Hypertension (DASH) diet. […] The 2020 Lancet Commission on Dementia Prevention describes population-based interventions and individually targeted interventions for Alzheimers primary prevention. […] Preventive interventions must address racial and ethnic disparities in Alzheimers risk that occur due to the following socioeconomic factors: low household income, low education attainment, and low literacy level.

• #36 Small Amounts of Moderate to Vigorous Physical Activity Are Associated with Big Reductions in Dementia Risk | Johns Hopkins | Bloomberg School of Public Health

  https://publichealth.jhu.edu/2025/small-amounts-of-moderate-to-vigorous-physical-activity-are-associated-with-big-reductions-in-dementia-risk

  A little movement could help prevent dementia, even for frail older adults, suggests a new study led by researchers at the Johns Hopkins Bloomberg School of Public Health. […] The researchers found that engaging in as little as 35 minutes of moderate to vigorous physical activity per week, compared to zero minutes per week, was associated with a 41% lower risk of developing dementia over an average four-year follow-up period. […] Our findings suggest that increasing physical activity, even as little as five minutes per day, can reduce dementia risk in older adults, says study lead author Amal Wanigatunga, PhD, MPH, assistant professor in the Bloomberg Schools Department of Epidemiology. […] This adds to a growing body of evidence that some exercise is better than nothing, especially with regard to an aging-related disorder that affects the brain that currently has no cure.

• #37 Physical activity and the risk of dementia | Alzheimer’s Society

  https://www.alzheimers.org.uk/about-dementia/managing-the-risk-of-dementia/reduce-your-risk-of-dementia/physical-activity

  Regular physical activity is one of the best things that you can do to reduce your risk of developing dementia. […] A lack of physical exercise is one of the main factors where the evidence is strong enough to show that it increases a persons risk of developing dementia. […] A lifelong approach to good health is the best way to lower your risk of dementia. […] There are some lifestyle behaviours with enough evidence to show that changing them will reduce your risk of dementia. […] Research has shown that people who take regular exercise may be up to 20% less likely to develop dementia than those who don’t take regular exercise. […] Sustaining physical activity throughout midlife also seems to have the best effect on reducing dementia risk. […] There is some evidence to show older people can also reduce their risk of dementia with regular exercise.

• #38 PROMISING STRATEGIES FOR THE PREVENTION OF DEMENTIA

  https://pmc.ncbi.nlm.nih.gov/articles/PMC2762111/

  Recognition of vascular risk factors may help to identify those people who are most at risk (and should be regularly screened) for dementia and who are most likely to benefit from preventative interventions. […] Recent trials have demonstrated that cognitive interventions may reduce the risk of cognitive impairment and slow cognitive decline. […] Recent attention is being paid to the role of physical activity as a potentially protective factor against the risk of dementia. […] People with limited social networks and low social engagement may be more likely to develop dementia compared to those with socially rich lives. […] Many of the risk factors for dementia, such as hypertension, diabetes, and obesity, may be modified by diet. […] It is well known that people, especially older adults, with depression have reduced cognitive performance.

• #39 Evidence-Based Prevention – Alzheimer’s Disease Research Center

  http://depts.washington.edu/mbwc/adrc/page/prevention

  2020 findings from the SPRINT-MIND study found that lowering blood pressure to under 120 showed a 19% reduction in those participants who went on to develop dementia during the study. […] In terms of brain and cognitive health, the best data support the Mediterranean diet, which includes relatively little red meat and emphasizes whole grains, fruits and vegetables, fish and shellfish, and nuts, olive oil and other healthy fats. […] A study published in Alzheimer’s Dementia of 923 adults aged 58-98 who maintained the MIND diet for 4.5 years showed a 53% reduction in the incidence of Alzheimer’s disease dementia. […] An NIH-funded study found that eating a Mediterranean diet slows some changes in the brain that may indicate early Alzheimers disease. […] According to UW MBWC’s Dr. Kristoffer Rhoads mindfulness meditation can boost memory and improve brain connections in people with mild cognitive impairment (MCI) and early stage dementia.

• #40 Dementia Insights: Primary Prevention of Dementia

  https://practicalneurology.com/articles/2020-oct/dementia-insights-primary-prevention-of-dementia

  The USPSTF recommends clinicians ask all adults about tobacco use. […] The USPSTF is updating 2015 recommendations to screen for high blood pressure in adults age 18 years or more. […] Lifestyle modification is the first line of antihypertensive treatment, and the Dietary Approaches to Stop Hypertension (DASH) diet is effective in treating hypertension with an effect size comparable to drug monotherapy. […] There is currently insufficient evidence to determine the effectiveness of lipid-lowering treatment (statins) and diabetes treatment for preventing age-related cognitive decline or clinical Alzheimer type dementia; both are recognized priorities for future research. […] It is reasonable to counsel patients to increase intake of particular food groups, including vegetables, fruits, fish, olive oil, and nuts. […] It is reasonable to counsel patients to increase intake of vegetables, fruits, nuts, and fish, which have been found protective for cognition in observational studies. […] We recommend screening patients with cognitive impairment for sleep dysfunction.

• #41 How to lower your dementia risk – Harvard Health

  https://www.health.harvard.edu/mind-and-mood/how-to-lower-your-dementia-risk

  „The most convincing evidence continues to be for the boring stuff aerobic exercise, a brain-healthy diet, and quality sleep,” says neuroscientist Dr. Daniel Daneshvar, chief of the division of brain injury rehabilitation with Harvard-affiliated Massachusetts General Hospital. „Even people with a family history of dementia could lower the risk by investing more in these basic healthy lifestyle habits.” Here’s how they help with dementia prevention. […] Aerobic exercise increases blood flow to the brain, supporting blood vessels and decreasing the risk of blood vessel damage. It also helps reduce inflammation, thought to be one of the main causes of abnormal protein buildup. […] There are several extensively studied diets that promote brain health, like the Mediterranean, DASH (Dietary Approaches to Stop Hypertension), and MIND (Mediterranean-DASH Intervention for Neurodegenerative Delay) diets. „These diets are linked to lower levels of brain-damaging chronic inflammation by reducing or eliminating red meat and processed foods and increasing the intake of antioxidant-rich fruits and vegetables and fatty fish high in omega-3 fatty acids,” says Dr. Daneshvar.

• #42

  https://journals.publishing.umich.edu/ujph/article/id/3946/

  Modifiable risk factors cause about a third of Alzheimers cases worldwide, demonstrating that risk factor reduction can aid in Alzheimers prevention. […] One lifestyle risk factor reduction strategy is regular physical activity due to its increase of neuroplasticity and high-density lipoprotein (HDL) cholesterol, as well as its reduction of inflammation and plaque formation. […] Another lifestyle risk factor reduction strategy is adherence to the MIND Diet for Neurodegenerative Delay, a combination of the Mediterranean diet and the Dietary Approaches to Stop Hypertension (DASH) diet. […] The 2020 Lancet Commission on Dementia Prevention describes population-based interventions and individually targeted interventions for Alzheimers primary prevention. […] Preventive interventions must address racial and ethnic disparities in Alzheimers risk that occur due to the following socioeconomic factors: low household income, low education attainment, and low literacy level.

• #43 Evidence-Based Prevention – Alzheimer’s Disease Research Center

  http://depts.washington.edu/mbwc/adrc/page/prevention

  2020 findings from the SPRINT-MIND study found that lowering blood pressure to under 120 showed a 19% reduction in those participants who went on to develop dementia during the study. […] In terms of brain and cognitive health, the best data support the Mediterranean diet, which includes relatively little red meat and emphasizes whole grains, fruits and vegetables, fish and shellfish, and nuts, olive oil and other healthy fats. […] A study published in Alzheimer’s Dementia of 923 adults aged 58-98 who maintained the MIND diet for 4.5 years showed a 53% reduction in the incidence of Alzheimer’s disease dementia. […] An NIH-funded study found that eating a Mediterranean diet slows some changes in the brain that may indicate early Alzheimers disease. […] According to UW MBWC’s Dr. Kristoffer Rhoads mindfulness meditation can boost memory and improve brain connections in people with mild cognitive impairment (MCI) and early stage dementia.

• #44 Can Alzheimer’s Be Prevented? | Alzheimer’s Association

  https://www.alz.org/alzheimers-dementia/research-and-progress/prevention

  Current evidence suggests that heart-healthy eating may also help protect the brain. Heart-healthy eating includes limiting the intake of sugar and saturated fats and making sure to eat plenty of fruits, vegetables, and whole grains. […] A number of studies indicate that maintaining strong social connections and keeping mentally active as we age might lower the risk of cognitive decline and Alzheimer’s. […] While research is not yet conclusive partially due to the need for more large-scale studies in diverse populations certain lifestyle choices, such as physical activity and diet, may help support brain health and prevent Alzheimer’s. Many of these lifestyle changes have been shown to lower the risk of other diseases, like heart disease and diabetes, which have been linked to Alzheimer’s. With few drawbacks and plenty of known benefits, healthy lifestyle choices can improve your health and possibly protect your brain.

• #45 Can Alzheimer’s Be Prevented? | Alzheimer’s Association

  https://www.alz.org/alzheimers-dementia/research-and-progress/prevention

  Current evidence suggests that heart-healthy eating may also help protect the brain. Heart-healthy eating includes limiting the intake of sugar and saturated fats and making sure to eat plenty of fruits, vegetables, and whole grains. […] A number of studies indicate that maintaining strong social connections and keeping mentally active as we age might lower the risk of cognitive decline and Alzheimer’s. […] While research is not yet conclusive partially due to the need for more large-scale studies in diverse populations certain lifestyle choices, such as physical activity and diet, may help support brain health and prevent Alzheimer’s. Many of these lifestyle changes have been shown to lower the risk of other diseases, like heart disease and diabetes, which have been linked to Alzheimer’s. With few drawbacks and plenty of known benefits, healthy lifestyle choices can improve your health and possibly protect your brain.

• #46 Prevent Alzheimer’s Disease – Pillar 1: Diet and Supplements

  https://alzheimersprevention.org/4-pillars-of-prevention/pillar-1-diet-supplements/

  Your brain is a flesh and blood organ that needs proper fuel to function well. Building a better memory, preventing Alzheimers and memory loss, and impacting the causes of Alzheimers disease all depend on your lifestyle. Your diet is critical to your brains health. And with the proper Alzheimers diet, you can actually influence the health of your genes. […] One of the best ways you can feed your brain for better memory is by avoiding a diet high in trans-fat and saturated fat. […] Eating foods that are high in antioxidants like vitamins C and E is a wonderful natural way to eliminate free radicals from your body. […] Scientists believe that a vast intake of fruits and vegetables, eating fish rich in omega-3 oils and vegetarian protein substitutes (such as soy) are protective against memory loss.

• #47 Prevent Alzheimer’s Disease – Pillar 1: Diet and Supplements

  https://alzheimersprevention.org/4-pillars-of-prevention/pillar-1-diet-supplements/

  Your brain is a flesh and blood organ that needs proper fuel to function well. Building a better memory, preventing Alzheimers and memory loss, and impacting the causes of Alzheimers disease all depend on your lifestyle. Your diet is critical to your brains health. And with the proper Alzheimers diet, you can actually influence the health of your genes. […] One of the best ways you can feed your brain for better memory is by avoiding a diet high in trans-fat and saturated fat. […] Eating foods that are high in antioxidants like vitamins C and E is a wonderful natural way to eliminate free radicals from your body. […] Scientists believe that a vast intake of fruits and vegetables, eating fish rich in omega-3 oils and vegetarian protein substitutes (such as soy) are protective against memory loss.

• #48 Dementia Insights: Primary Prevention of Dementia

  https://practicalneurology.com/articles/2020-oct/dementia-insights-primary-prevention-of-dementia

  The USPSTF recommends clinicians ask all adults about tobacco use. […] The USPSTF is updating 2015 recommendations to screen for high blood pressure in adults age 18 years or more. […] Lifestyle modification is the first line of antihypertensive treatment, and the Dietary Approaches to Stop Hypertension (DASH) diet is effective in treating hypertension with an effect size comparable to drug monotherapy. […] There is currently insufficient evidence to determine the effectiveness of lipid-lowering treatment (statins) and diabetes treatment for preventing age-related cognitive decline or clinical Alzheimer type dementia; both are recognized priorities for future research. […] It is reasonable to counsel patients to increase intake of particular food groups, including vegetables, fruits, fish, olive oil, and nuts. […] It is reasonable to counsel patients to increase intake of vegetables, fruits, nuts, and fish, which have been found protective for cognition in observational studies. […] We recommend screening patients with cognitive impairment for sleep dysfunction.

• #49 Dementia Insights: Primary Prevention of Dementia

  https://practicalneurology.com/articles/2020-oct/dementia-insights-primary-prevention-of-dementia

  The USPSTF recommends clinicians ask all adults about tobacco use. […] The USPSTF is updating 2015 recommendations to screen for high blood pressure in adults age 18 years or more. […] Lifestyle modification is the first line of antihypertensive treatment, and the Dietary Approaches to Stop Hypertension (DASH) diet is effective in treating hypertension with an effect size comparable to drug monotherapy. […] There is currently insufficient evidence to determine the effectiveness of lipid-lowering treatment (statins) and diabetes treatment for preventing age-related cognitive decline or clinical Alzheimer type dementia; both are recognized priorities for future research. […] It is reasonable to counsel patients to increase intake of particular food groups, including vegetables, fruits, fish, olive oil, and nuts. […] It is reasonable to counsel patients to increase intake of vegetables, fruits, nuts, and fish, which have been found protective for cognition in observational studies. […] We recommend screening patients with cognitive impairment for sleep dysfunction.

• #50 How to lower your dementia risk – Harvard Health

  https://www.health.harvard.edu/mind-and-mood/how-to-lower-your-dementia-risk

  „The most convincing evidence continues to be for the boring stuff aerobic exercise, a brain-healthy diet, and quality sleep,” says neuroscientist Dr. Daniel Daneshvar, chief of the division of brain injury rehabilitation with Harvard-affiliated Massachusetts General Hospital. „Even people with a family history of dementia could lower the risk by investing more in these basic healthy lifestyle habits.” Here’s how they help with dementia prevention. […] Aerobic exercise increases blood flow to the brain, supporting blood vessels and decreasing the risk of blood vessel damage. It also helps reduce inflammation, thought to be one of the main causes of abnormal protein buildup. […] There are several extensively studied diets that promote brain health, like the Mediterranean, DASH (Dietary Approaches to Stop Hypertension), and MIND (Mediterranean-DASH Intervention for Neurodegenerative Delay) diets. „These diets are linked to lower levels of brain-damaging chronic inflammation by reducing or eliminating red meat and processed foods and increasing the intake of antioxidant-rich fruits and vegetables and fatty fish high in omega-3 fatty acids,” says Dr. Daneshvar.

• #51 Reduce your risk of dementia | Alzheimer’s Society

  https://www.alzheimers.org.uk/about-dementia/managing-the-risk-of-dementia/reduce-your-risk-of-dementia

  Social isolation can greatly increase a person’s risk of dementia. […] Certain health conditions, such as high blood pressure, high cholesterol or diabetes can increase the risk of getting dementia. […] Uncorrected vision loss increases a person’s risk of developing dementia. […] Hearing loss is related to an increased risk of developing dementia and may be an early symptom. […] Traumatic brain injuries are caused by a blow or jolt to the head especially when the person is knocked out unconscious. […] Certain forms of air pollution increase a person’s risk of dementia.

• #52 Reducing Risk for Dementia | Alzheimer’s Disease and Dementia | CDC

  https://www.cdc.gov/alzheimers-dementia/prevention/index.html

  There are common conditions and lifestyle behaviors that can increase your risk for dementia. […] Learn what they are and the healthy lifestyle habits that can lower your risk of developing dementia, including Alzheimer’s disease. […] Nearly 45% of all dementia cases may be prevented or delayed. […] Small changes can make a big difference to lower your risk of dementia. […] Healthy habits can benefit brain health by: […] Reducing the chances of worsening memory loss. […] Slowing the progression of dementia, including Alzheimer’s. […] Regular physical activity can help you prevent, delay, or manage chronic diseases, like dementia. […] The good news is type 2 diabetes can be prevented or delayed. […] High blood pressure can damage blood vessels and limit blood flow to the brain, which does damage to the brain. […] Treating hearing loss (using hearing aids) may reduce the risk of dementia. […] If you drink alcohol, do so in moderation. […] Quit smoking to reduce your risk dementia. Quitting smoking also reduces other risks for dementia, like stroke, type 2 diabetes, and high blood pressure.

• #53 Evidence-Based Prevention – Alzheimer’s Disease Research Center

  http://depts.washington.edu/mbwc/adrc/page/prevention

  2020 findings from the SPRINT-MIND study found that lowering blood pressure to under 120 showed a 19% reduction in those participants who went on to develop dementia during the study. […] In terms of brain and cognitive health, the best data support the Mediterranean diet, which includes relatively little red meat and emphasizes whole grains, fruits and vegetables, fish and shellfish, and nuts, olive oil and other healthy fats. […] A study published in Alzheimer’s Dementia of 923 adults aged 58-98 who maintained the MIND diet for 4.5 years showed a 53% reduction in the incidence of Alzheimer’s disease dementia. […] An NIH-funded study found that eating a Mediterranean diet slows some changes in the brain that may indicate early Alzheimers disease. […] According to UW MBWC’s Dr. Kristoffer Rhoads mindfulness meditation can boost memory and improve brain connections in people with mild cognitive impairment (MCI) and early stage dementia.

• #54 Targeting 14 lifestyle factors may prevent up to 45% of dementia cases | Cognitive Vitality | Alzheimer’s Drug Discovery Foundation

  https://www.alzdiscovery.org/cognitive-vitality/blog/targeting-14-lifestyle-factors-may-prevent-up-to-45-of-dementia-cases

  Studies suggest that having hypertension in midlife increases the risk of both vascular dementia and Alzheimer’s disease. […] People who are obese in midlife have an increased risk of dementia compared to those with healthy body weight. […] Heavy drinking is associated with cognitive impairment and dementia. […] Social isolation is a risk factor not only for dementia but also for hypertension, coronary heart disease, and depression. […] Many studies show that air pollution is a risk factor for dementia and cognitive impairment. […] An analysis of numerous cohort studies reported that vision impairment is associated with a higher risk of both dementia and cognitive impairment. […] The Lancet report is great news in that there are concrete steps you can take to reduce dementia risk. […] These recommendations are consistent with evidence from a seminal randomized controlled trial called FINGER that showed a group of lifestyle interventions that addressed many of these risk factors improved cognitive function in older people.

• #55 Prevention of dementia – Wikipedia

  https://en.wikipedia.org/wiki/Prevention_of_dementia

  Diabetes mellitus is a risk factor for dementia, and thus the risk of dementia is lowered with anti-diabetic drugs. […] Estrogen may play a role in the prevention of dementia. […] Non-steroidal anti-inflammatory drugs (NSAIDs) can decrease the risk of developing Alzheimer’s and Parkinson’s diseases. […] There is as yet no vaccine against dementia. […] Anticholinergic medications are often prescribed to treat health conditions commonly experienced by older people including overactive bladder and many commonly used medications have anticholinergic activity.

• #56 Alzheimer’s Disease Prevention Strategies

  https://www.verywellhealth.com/alzheimers-prevention-4014142

  Research suggests that smoking can affect your brain and memory. […] The results, published in the Journal of Alzheimer’s Disease in 2025, found that people who smoked had a 1.3 times higher odds of developing dementia. […] Obesity is linked to a higher risk for Alzheimers disease. […] The link between high blood sugar and dementia risk is so profound that Alzheimer’s disease has been nicknamed „type 3 diabetes.” […] Keeping blood sugar within the healthy range (using diet, exercise, and medication when needed) can prevent insulin resistance and type 2 diabetes. […] Mental activity has been associated with increased cognitive reserve, which refers to the brain’s resilience and ability to think and function as you age. […] Spending time with friends is essential for maintaining quality of life and improving mental well-being.

• #57 Reducing Risk for Dementia | Alzheimer’s Disease and Dementia | CDC

  https://www.cdc.gov/alzheimers-dementia/prevention/index.html

  There are common conditions and lifestyle behaviors that can increase your risk for dementia. […] Learn what they are and the healthy lifestyle habits that can lower your risk of developing dementia, including Alzheimer’s disease. […] Nearly 45% of all dementia cases may be prevented or delayed. […] Small changes can make a big difference to lower your risk of dementia. […] Healthy habits can benefit brain health by: […] Reducing the chances of worsening memory loss. […] Slowing the progression of dementia, including Alzheimer’s. […] Regular physical activity can help you prevent, delay, or manage chronic diseases, like dementia. […] The good news is type 2 diabetes can be prevented or delayed. […] High blood pressure can damage blood vessels and limit blood flow to the brain, which does damage to the brain. […] Treating hearing loss (using hearing aids) may reduce the risk of dementia. […] If you drink alcohol, do so in moderation. […] Quit smoking to reduce your risk dementia. Quitting smoking also reduces other risks for dementia, like stroke, type 2 diabetes, and high blood pressure.

• #58 Alzheimer’s Disease Prevention Strategies

  https://www.verywellhealth.com/alzheimers-prevention-4014142

  Research suggests that smoking can affect your brain and memory. […] The results, published in the Journal of Alzheimer’s Disease in 2025, found that people who smoked had a 1.3 times higher odds of developing dementia. […] Obesity is linked to a higher risk for Alzheimers disease. […] The link between high blood sugar and dementia risk is so profound that Alzheimer’s disease has been nicknamed „type 3 diabetes.” […] Keeping blood sugar within the healthy range (using diet, exercise, and medication when needed) can prevent insulin resistance and type 2 diabetes. […] Mental activity has been associated with increased cognitive reserve, which refers to the brain’s resilience and ability to think and function as you age. […] Spending time with friends is essential for maintaining quality of life and improving mental well-being.

• #59 Targeting 14 lifestyle factors may prevent up to 45% of dementia cases | Cognitive Vitality | Alzheimer’s Drug Discovery Foundation

  https://www.alzdiscovery.org/cognitive-vitality/blog/targeting-14-lifestyle-factors-may-prevent-up-to-45-of-dementia-cases

  Targeting 14 lifestyle factors may prevent up to 45% of dementia cases. […] In July 2024, the Lancet Commission added two new risk factors and reported that 45% of dementia cases could be prevented by fully addressing 14 lifestyle factors. […] Not completing secondary education increases your risk of dementia. […] Lifelong learning is associated with improved brain health, and higher levels of cognitive activity at mid- or late-life are linked to delayed onset of cognitive impairment. […] Many high-quality observational studies suggest an association between hearing loss and subsequent dementia. […] Studies have found that with every 10-dB decrease in hearing ability, there is a 4 to 24% higher risk of dementia. […] High LDL cholesterol in midlife is associated with a higher risk of dementia.

• #60 Dementia – Symptoms and causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/dementia/symptoms-causes/syc-20352013

  Manage cardiovascular risk factors. Treat high blood pressure, high cholesterol and diabetes. Pay attention to your levels of LDL cholesterol and get treatment if the levels are too high. High levels of LDL in middle age raises the risk of dementia. Lose weight if you’re overweight. […] Treat health conditions. See your doctor for treatment of depression or anxiety. […] Maintain a healthy diet. A diet such as the Mediterranean diet might promote health and lower the risk of developing dementia. A Mediterranean diet is rich in fruits, vegetables, whole grains and omega-3 fatty acids, which are commonly found in certain fish and nuts. This type of diet also improves cardiovascular health, which also may help lower dementia risk. […] Get good-quality sleep. Practice good sleep hygiene. Talk to a health care professional if you snore loudly or have periods where you stop breathing or gasp during sleep.

• #61 Targeting 14 lifestyle factors may prevent up to 45% of dementia cases | Cognitive Vitality | Alzheimer’s Drug Discovery Foundation

  https://www.alzdiscovery.org/cognitive-vitality/blog/targeting-14-lifestyle-factors-may-prevent-up-to-45-of-dementia-cases

  Targeting 14 lifestyle factors may prevent up to 45% of dementia cases. […] In July 2024, the Lancet Commission added two new risk factors and reported that 45% of dementia cases could be prevented by fully addressing 14 lifestyle factors. […] Not completing secondary education increases your risk of dementia. […] Lifelong learning is associated with improved brain health, and higher levels of cognitive activity at mid- or late-life are linked to delayed onset of cognitive impairment. […] Many high-quality observational studies suggest an association between hearing loss and subsequent dementia. […] Studies have found that with every 10-dB decrease in hearing ability, there is a 4 to 24% higher risk of dementia. […] High LDL cholesterol in midlife is associated with a higher risk of dementia.

• #62 Targeting 14 lifestyle factors may prevent up to 45% of dementia cases | Cognitive Vitality | Alzheimer’s Drug Discovery Foundation

  https://www.alzdiscovery.org/cognitive-vitality/blog/targeting-14-lifestyle-factors-may-prevent-up-to-45-of-dementia-cases

  Targeting 14 lifestyle factors may prevent up to 45% of dementia cases. […] In July 2024, the Lancet Commission added two new risk factors and reported that 45% of dementia cases could be prevented by fully addressing 14 lifestyle factors. […] Not completing secondary education increases your risk of dementia. […] Lifelong learning is associated with improved brain health, and higher levels of cognitive activity at mid- or late-life are linked to delayed onset of cognitive impairment. […] Many high-quality observational studies suggest an association between hearing loss and subsequent dementia. […] Studies have found that with every 10-dB decrease in hearing ability, there is a 4 to 24% higher risk of dementia. […] High LDL cholesterol in midlife is associated with a higher risk of dementia.

• #63 Reducing Risk for Dementia | Alzheimer’s Disease and Dementia | CDC

  https://www.cdc.gov/alzheimers-dementia/prevention/index.html

  There are common conditions and lifestyle behaviors that can increase your risk for dementia. […] Learn what they are and the healthy lifestyle habits that can lower your risk of developing dementia, including Alzheimer’s disease. […] Nearly 45% of all dementia cases may be prevented or delayed. […] Small changes can make a big difference to lower your risk of dementia. […] Healthy habits can benefit brain health by: […] Reducing the chances of worsening memory loss. […] Slowing the progression of dementia, including Alzheimer’s. […] Regular physical activity can help you prevent, delay, or manage chronic diseases, like dementia. […] The good news is type 2 diabetes can be prevented or delayed. […] High blood pressure can damage blood vessels and limit blood flow to the brain, which does damage to the brain. […] Treating hearing loss (using hearing aids) may reduce the risk of dementia. […] If you drink alcohol, do so in moderation. […] Quit smoking to reduce your risk dementia. Quitting smoking also reduces other risks for dementia, like stroke, type 2 diabetes, and high blood pressure.

• #64 Dementia – Symptoms and causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/dementia/symptoms-causes/syc-20352013

  Treat hearing loss. People with hearing loss have a greater chance of developing problems with thinking, known as cognitive decline. Early treatment of hearing loss, such as use of hearing aids, might help decrease the risk. […] Get regular eye exams and treat vision loss. Research suggests that not treating vision loss may be associated with a raised risk of dementia.

• #65 Targeting 14 lifestyle factors may prevent up to 45% of dementia cases | Cognitive Vitality | Alzheimer’s Drug Discovery Foundation

  https://www.alzdiscovery.org/cognitive-vitality/blog/targeting-14-lifestyle-factors-may-prevent-up-to-45-of-dementia-cases

  Studies suggest that having hypertension in midlife increases the risk of both vascular dementia and Alzheimer’s disease. […] People who are obese in midlife have an increased risk of dementia compared to those with healthy body weight. […] Heavy drinking is associated with cognitive impairment and dementia. […] Social isolation is a risk factor not only for dementia but also for hypertension, coronary heart disease, and depression. […] Many studies show that air pollution is a risk factor for dementia and cognitive impairment. […] An analysis of numerous cohort studies reported that vision impairment is associated with a higher risk of both dementia and cognitive impairment. […] The Lancet report is great news in that there are concrete steps you can take to reduce dementia risk. […] These recommendations are consistent with evidence from a seminal randomized controlled trial called FINGER that showed a group of lifestyle interventions that addressed many of these risk factors improved cognitive function in older people.

• #66 Dementia – Symptoms and causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/dementia/symptoms-causes/syc-20352013

  Treat hearing loss. People with hearing loss have a greater chance of developing problems with thinking, known as cognitive decline. Early treatment of hearing loss, such as use of hearing aids, might help decrease the risk. […] Get regular eye exams and treat vision loss. Research suggests that not treating vision loss may be associated with a raised risk of dementia.

• #67 Targeting 14 lifestyle factors may prevent up to 45% of dementia cases | Cognitive Vitality | Alzheimer’s Drug Discovery Foundation

  https://www.alzdiscovery.org/cognitive-vitality/blog/targeting-14-lifestyle-factors-may-prevent-up-to-45-of-dementia-cases

  People with depression have a higher risk of dementia than those without depression. […] Depression at all adult ages is associated with higher dementia risk, but the evidence is most clear for midlife depression. […] Traumatic brain injury is associated with a higher dementia risk, possibly leading to earlier onset of dementia by two to three years than in people without traumatic brain injury. […] Being physically active at all ages is associated with better cognition and lower dementia risk. […] Newer evidence suggests that the age of onset makes a difference, with a midlife onset of type 2 diabetes being significantly associated with higher dementia risk. […] Cigarettes and cigarette smoke contain more than 4,700 chemical compounds, including some that are highly toxic. […] Observational studies have shown that people who smoke are at a higher risk of developing all types of dementia and a much higher risk for Alzheimer’s disease.

• #68 Targeting 14 lifestyle factors may prevent up to 45% of dementia cases | Cognitive Vitality | Alzheimer’s Drug Discovery Foundation

  https://www.alzdiscovery.org/cognitive-vitality/blog/targeting-14-lifestyle-factors-may-prevent-up-to-45-of-dementia-cases

  People with depression have a higher risk of dementia than those without depression. […] Depression at all adult ages is associated with higher dementia risk, but the evidence is most clear for midlife depression. […] Traumatic brain injury is associated with a higher dementia risk, possibly leading to earlier onset of dementia by two to three years than in people without traumatic brain injury. […] Being physically active at all ages is associated with better cognition and lower dementia risk. […] Newer evidence suggests that the age of onset makes a difference, with a midlife onset of type 2 diabetes being significantly associated with higher dementia risk. […] Cigarettes and cigarette smoke contain more than 4,700 chemical compounds, including some that are highly toxic. […] Observational studies have shown that people who smoke are at a higher risk of developing all types of dementia and a much higher risk for Alzheimer’s disease.

• #69 Can dementia be prevented – NHS

  https://www.nhs.uk/conditions/dementia/about-dementia/prevention/

  A lack of regular physical activity can increase your risk of cardiovascular disease, becoming overweight or obese, and type 2 diabetes, which are all linked to a higher risk of dementia. […] If you’re concerned that you, a relative, or a friend may be depressed, talk to a GP. They may refer you for cognitive behavioural therapy (CBT), or a talking therapy. […] The NHS Health Check can help find early signs and tell you if you’re at higher risk of certain health problems that can also increase your risk of dementia.

• #70 PROMISING STRATEGIES FOR THE PREVENTION OF DEMENTIA

  https://pmc.ncbi.nlm.nih.gov/articles/PMC2762111/

  Recognition of vascular risk factors may help to identify those people who are most at risk (and should be regularly screened) for dementia and who are most likely to benefit from preventative interventions. […] Recent trials have demonstrated that cognitive interventions may reduce the risk of cognitive impairment and slow cognitive decline. […] Recent attention is being paid to the role of physical activity as a potentially protective factor against the risk of dementia. […] People with limited social networks and low social engagement may be more likely to develop dementia compared to those with socially rich lives. […] Many of the risk factors for dementia, such as hypertension, diabetes, and obesity, may be modified by diet. […] It is well known that people, especially older adults, with depression have reduced cognitive performance.

• #71 Reduce your risk of dementia | Alzheimer’s Society

  https://www.alzheimers.org.uk/about-dementia/managing-the-risk-of-dementia/reduce-your-risk-of-dementia

  Social isolation can greatly increase a person’s risk of dementia. […] Certain health conditions, such as high blood pressure, high cholesterol or diabetes can increase the risk of getting dementia. […] Uncorrected vision loss increases a person’s risk of developing dementia. […] Hearing loss is related to an increased risk of developing dementia and may be an early symptom. […] Traumatic brain injuries are caused by a blow or jolt to the head especially when the person is knocked out unconscious. […] Certain forms of air pollution increase a person’s risk of dementia.

• #72 Alzheimer’s Disease Prevention Strategies

  https://www.verywellhealth.com/alzheimers-prevention-4014142

  Research suggests that smoking can affect your brain and memory. […] The results, published in the Journal of Alzheimer’s Disease in 2025, found that people who smoked had a 1.3 times higher odds of developing dementia. […] Obesity is linked to a higher risk for Alzheimers disease. […] The link between high blood sugar and dementia risk is so profound that Alzheimer’s disease has been nicknamed „type 3 diabetes.” […] Keeping blood sugar within the healthy range (using diet, exercise, and medication when needed) can prevent insulin resistance and type 2 diabetes. […] Mental activity has been associated with increased cognitive reserve, which refers to the brain’s resilience and ability to think and function as you age. […] Spending time with friends is essential for maintaining quality of life and improving mental well-being.

• #73 Preventing Dementia | Stanford Health Care

  https://stanfordhealthcare.org/medical-conditions/brain-and-nerves/dementia/prevention.html

  Can dementia be prevented? […] Dementia is hard to prevent, because what causes it often is not known. But people who have dementia caused by stroke may be able to prevent future declines by lowering their risk of heart disease and stroke. Even if you don’t have these known risks, your overall health can benefit from these strategies: […] Don’t smoke. […] Stay at a healthy weight. […] Get plenty of exercise. […] Eat healthy food. […] Manage health problems including diabetes, high blood pressure, and high cholesterol. […] Stay mentally alert by learning new hobbies, reading, or solving crossword puzzles. […] Stay involved socially. Attend community activities, church, or support groups. […] If your doctor recommends it, take aspirin.

• #74 Preventing Dementia | Stanford Health Care

  https://stanfordhealthcare.org/medical-conditions/brain-and-nerves/dementia/prevention.html

  Can dementia be prevented? […] Dementia is hard to prevent, because what causes it often is not known. But people who have dementia caused by stroke may be able to prevent future declines by lowering their risk of heart disease and stroke. Even if you don’t have these known risks, your overall health can benefit from these strategies: […] Don’t smoke. […] Stay at a healthy weight. […] Get plenty of exercise. […] Eat healthy food. […] Manage health problems including diabetes, high blood pressure, and high cholesterol. […] Stay mentally alert by learning new hobbies, reading, or solving crossword puzzles. […] Stay involved socially. Attend community activities, church, or support groups. […] If your doctor recommends it, take aspirin.

• #75 Preventing Dementia | Stanford Health Care

  https://stanfordhealthcare.org/medical-conditions/brain-and-nerves/dementia/prevention.html

  Can dementia be prevented? […] Dementia is hard to prevent, because what causes it often is not known. But people who have dementia caused by stroke may be able to prevent future declines by lowering their risk of heart disease and stroke. Even if you don’t have these known risks, your overall health can benefit from these strategies: […] Don’t smoke. […] Stay at a healthy weight. […] Get plenty of exercise. […] Eat healthy food. […] Manage health problems including diabetes, high blood pressure, and high cholesterol. […] Stay mentally alert by learning new hobbies, reading, or solving crossword puzzles. […] Stay involved socially. Attend community activities, church, or support groups. […] If your doctor recommends it, take aspirin.

• #76 Dementia prevention and treatment | CIHI

  https://www.cihi.ca/en/dementia-in-canada/spotlight-on-dementia-issues/dementia-prevention-and-treatment

  There is no way to prevent all types of dementia; however, having a healthy lifestyle and managing chronic conditions help improve overall health and reduce the risk. […] Studies suggest that about a third of dementia cases might be delayed or prevented by addressing potentially modifiable risk factors. […] Treat hypertension. Hypertension can affect brain function by damaging blood vessels. Early treatment can reduce the risk of vascular dementia. […] Continue your education. Education maintains an individuals cognitive reserve ones resistance to damage of the brain. […] Get regular physical activity. Exercise helps to improve balance and mood, reduce falls and improve overall function. […] Maintain social engagement. Regular social activity has been shown to help improve thinking, concentration, memory skills and mood. […] Reduce or eliminate smoking. Neurotoxins in cigarettes can harm the brain and lead to poor cardiovascular health, which is linked to cognitive decline. […] Manage other conditions. Chronic conditions like hearing loss, depression, diabetes and obesity increase the risk of dementia.

• #77 Targeting 14 lifestyle factors may prevent up to 45% of dementia cases | Cognitive Vitality | Alzheimer’s Drug Discovery Foundation

  https://www.alzdiscovery.org/cognitive-vitality/blog/targeting-14-lifestyle-factors-may-prevent-up-to-45-of-dementia-cases

  Studies suggest that having hypertension in midlife increases the risk of both vascular dementia and Alzheimer’s disease. […] People who are obese in midlife have an increased risk of dementia compared to those with healthy body weight. […] Heavy drinking is associated with cognitive impairment and dementia. […] Social isolation is a risk factor not only for dementia but also for hypertension, coronary heart disease, and depression. […] Many studies show that air pollution is a risk factor for dementia and cognitive impairment. […] An analysis of numerous cohort studies reported that vision impairment is associated with a higher risk of both dementia and cognitive impairment. […] The Lancet report is great news in that there are concrete steps you can take to reduce dementia risk. […] These recommendations are consistent with evidence from a seminal randomized controlled trial called FINGER that showed a group of lifestyle interventions that addressed many of these risk factors improved cognitive function in older people.

• #78 How to lower your dementia risk – Harvard Health

  https://www.health.harvard.edu/mind-and-mood/how-to-lower-your-dementia-risk

  During sleep, the brain clears out harmful beta-amyloid proteins. But the cleaning process can’t do a complete job if sleep is regularly disrupted by insomnia, sleep apnea, or other issues that cause you to wake during the night. „Eventually, this can cause or exacerbate abnormal protein buildup,” says Dr. Daneshvar. […] Another way to protect your brain from dementia is to socialize more. A study published online Oct. 24, 2023, by JAMA Neurology found that socially isolated older adults have a 27% higher chance of developing dementia than older adults who aren’t isolated. „Regular interactions activate mental processes, including attention and memory, which can bolster cognition,” says neuroscientist Dr. Daniel Daneshvar with Massachusetts General Hospital.

• #79 Dementia – reducing your risk | Better Health Channel

  https://www.betterhealth.vic.gov.au/health/conditionsandtreatments/dementia-reducing-your-risk

  A range of lifestyle and health strategies may keep your brain healthy and reduce your risk of developing dementia. […] Any activity that involves thinking and learning can improve your brain health and help protect against dementia. […] Regular and enjoyable interactions with friends, family and others may help reduce your risk of dementia. […] Drinking an excessive amount of alcohol can damage your brain and increase your risk of dementia. […] Research suggests the foods that are good for your heart and body may also be good for brain health and protect against dementia. […] People who are physically active have a lower risk of heart disease and stroke. […] Research shows that people who have high blood pressure, high cholesterol, diabetes, or are obese, particularly around middle age, have a greater risk of developing dementia later in life.

• #80 Dementia prevention and treatment | CIHI

  https://www.cihi.ca/en/dementia-in-canada/spotlight-on-dementia-issues/dementia-prevention-and-treatment

  There is no way to prevent all types of dementia; however, having a healthy lifestyle and managing chronic conditions help improve overall health and reduce the risk. […] Studies suggest that about a third of dementia cases might be delayed or prevented by addressing potentially modifiable risk factors. […] Treat hypertension. Hypertension can affect brain function by damaging blood vessels. Early treatment can reduce the risk of vascular dementia. […] Continue your education. Education maintains an individuals cognitive reserve ones resistance to damage of the brain. […] Get regular physical activity. Exercise helps to improve balance and mood, reduce falls and improve overall function. […] Maintain social engagement. Regular social activity has been shown to help improve thinking, concentration, memory skills and mood. […] Reduce or eliminate smoking. Neurotoxins in cigarettes can harm the brain and lead to poor cardiovascular health, which is linked to cognitive decline. […] Manage other conditions. Chronic conditions like hearing loss, depression, diabetes and obesity increase the risk of dementia.

• #81 How to lower your dementia risk – Harvard Health

  https://www.health.harvard.edu/mind-and-mood/how-to-lower-your-dementia-risk

  During sleep, the brain clears out harmful beta-amyloid proteins. But the cleaning process can’t do a complete job if sleep is regularly disrupted by insomnia, sleep apnea, or other issues that cause you to wake during the night. „Eventually, this can cause or exacerbate abnormal protein buildup,” says Dr. Daneshvar. […] Another way to protect your brain from dementia is to socialize more. A study published online Oct. 24, 2023, by JAMA Neurology found that socially isolated older adults have a 27% higher chance of developing dementia than older adults who aren’t isolated. „Regular interactions activate mental processes, including attention and memory, which can bolster cognition,” says neuroscientist Dr. Daniel Daneshvar with Massachusetts General Hospital.

• #82 Prevention of dementia – Wikipedia

  https://en.wikipedia.org/wiki/Prevention_of_dementia

  Diabetes mellitus is a risk factor for dementia, and thus the risk of dementia is lowered with anti-diabetic drugs. […] Estrogen may play a role in the prevention of dementia. […] Non-steroidal anti-inflammatory drugs (NSAIDs) can decrease the risk of developing Alzheimer’s and Parkinson’s diseases. […] There is as yet no vaccine against dementia. […] Anticholinergic medications are often prescribed to treat health conditions commonly experienced by older people including overactive bladder and many commonly used medications have anticholinergic activity.

• #83 Prevention of dementia – Wikipedia

  https://en.wikipedia.org/wiki/Prevention_of_dementia

  Diabetes mellitus is a risk factor for dementia, and thus the risk of dementia is lowered with anti-diabetic drugs. […] Estrogen may play a role in the prevention of dementia. […] Non-steroidal anti-inflammatory drugs (NSAIDs) can decrease the risk of developing Alzheimer’s and Parkinson’s diseases. […] There is as yet no vaccine against dementia. […] Anticholinergic medications are often prescribed to treat health conditions commonly experienced by older people including overactive bladder and many commonly used medications have anticholinergic activity.

• #84 Azthena logo with the word Azthena

  https://www.news-medical.net/health/Dementia-Prevention.aspx

  Smoking can cause the blood vessels to narrow. This gives rise to high blood pressure. This also raises the risk of developing cardiovascular diseases, cancer and vascular dementia. […] Excessive alcohol use may lead to several problems including obesity, high blood pressure, liver damage etc. Reduction of risk of high blood pressure, cardiovascular disease and vascular dementia involves adhering to recommended limits for alcohol consumption. […] Being overweight and obese raises the risk of cardiovascular diseases and vascular dementia. […] Regular exercise is good for the cardiovascular system and may prevent vascular dementias. […] Detecting certain medical conditions early and treating them effectively also reduces the risk of dementias. […] This involves certain brain activity exercises. Studies have shown that rates of dementia are lower in people who remain as mentally and physically active as long as possible. […] Certain drugs like Non-steroidal anti-inflammatory drugs (NSAIDs) can decrease the risk of developing Alzheimer’s and Parkinson’s diseases.

• #85 Metformin in Alzheimer’s dementia Prevention (MAP) Study | Division of General Medicine

  https://www.genmed.columbia.edu/research/research-centers-and-programs/center-aging-and-health-disparities-cahd/metformin-alzheimers-dementia-prevention-map-study

  Metformin in Alzheimers dementia Prevention (MAP) is a research study investigating whether Metformin can prevent memory decline in individuals experiencing mild memory concerns. […] Join our cause in combating dementia caused by Alzheimer’s disease.

• #86 Metformin in Alzheimer’s dementia Prevention (MAP) Study | Division of General Medicine

  https://www.genmed.columbia.edu/research/research-centers-and-programs/center-aging-and-health-disparities-cahd/metformin-alzheimers-dementia-prevention-map-study

  Metformin in Alzheimers dementia Prevention (MAP) is a research study investigating whether Metformin can prevent memory decline in individuals experiencing mild memory concerns. […] Join our cause in combating dementia caused by Alzheimer’s disease.

• #87 Blood Pressure Medication and Dementia Prevention: The Promising Link – June 14, 2023 – USC Schaeffer

  https://healthpolicy.usc.edu/research/blood-pressure-medication-and-dementia-prevention-the-promising-link/

  As dementia continues to impact millions of people worldwide, researchers and policymakers have urgently sought effective treatments to prevent and treat the disease. One promising area of research is the potential for existing medications for chronic conditions to reduce the risk of dementia or slow its onset. […] A growing body of research highlights existing blood pressure medications as one potential avenue for reducing dementia risk. […] Antihypertensives may reduce dementia risk directly by lowering blood pressure, a risk factor for cardiovascular disease, stroke and subsequent dementia. […] Some antihypertensives are hypothesized to impact Alzheimer’s disease pathology and provide further protection against this common form of dementia. […] Antihypertensives may provide a low-cost and scalable opportunity to reduce dementia incidence worldwide. […] Real-world pragmatic trials may offer a strategy for measuring the complex relationships between medication class, sex, race and ethnicity for informing effective treatment and prevention strategies for dementia.

• #88 Prevention and Treatments for Dementia – Baptist Health

  https://www.baptisthealth.com/blog/baptist-health/prevention-and-treatments-for-dementia

  Some of the vitamins and supplements used to treat dementia include: B Vitamins. B3, B6, B12 and Folic Acid. Some research indicates that those taking a B supplement vitamin are less likely to develop dementia. Vitamin E. Research has shown patients with dementia taking vitamin E have a slower progression of symptoms. Omega-3 fatty acids. Some research has linked a high intake of omega-3s with a possible decrease in dementia risk and cognitive decline. Vitamin D. Some research shows persons with lower levels of vitamin D have worsened cognitive function.

• #89 Prevention and Treatments for Dementia – Baptist Health

  https://www.baptisthealth.com/blog/baptist-health/prevention-and-treatments-for-dementia

  Some of the vitamins and supplements used to treat dementia include: B Vitamins. B3, B6, B12 and Folic Acid. Some research indicates that those taking a B supplement vitamin are less likely to develop dementia. Vitamin E. Research has shown patients with dementia taking vitamin E have a slower progression of symptoms. Omega-3 fatty acids. Some research has linked a high intake of omega-3s with a possible decrease in dementia risk and cognitive decline. Vitamin D. Some research shows persons with lower levels of vitamin D have worsened cognitive function.

• #90 Prevention and Treatments for Dementia – Baptist Health

  https://www.baptisthealth.com/blog/baptist-health/prevention-and-treatments-for-dementia

  Some of the vitamins and supplements used to treat dementia include: B Vitamins. B3, B6, B12 and Folic Acid. Some research indicates that those taking a B supplement vitamin are less likely to develop dementia. Vitamin E. Research has shown patients with dementia taking vitamin E have a slower progression of symptoms. Omega-3 fatty acids. Some research has linked a high intake of omega-3s with a possible decrease in dementia risk and cognitive decline. Vitamin D. Some research shows persons with lower levels of vitamin D have worsened cognitive function.

• #91 Prevention and Treatments for Dementia – Baptist Health

  https://www.baptisthealth.com/blog/baptist-health/prevention-and-treatments-for-dementia

  Some of the vitamins and supplements used to treat dementia include: B Vitamins. B3, B6, B12 and Folic Acid. Some research indicates that those taking a B supplement vitamin are less likely to develop dementia. Vitamin E. Research has shown patients with dementia taking vitamin E have a slower progression of symptoms. Omega-3 fatty acids. Some research has linked a high intake of omega-3s with a possible decrease in dementia risk and cognitive decline. Vitamin D. Some research shows persons with lower levels of vitamin D have worsened cognitive function.

• #92 Dementia – Symptoms and causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/dementia/symptoms-causes/syc-20352013

  Keep your mind active. Mentally stimulating activities might delay the onset of dementia and decrease its effects. Spend time reading, solving puzzles and playing word games. […] Be physically and socially active. Physical activity and social interaction might delay the onset of dementia and reduce its symptoms. Aim for 150 minutes of exercise a week. […] Quit smoking. Some studies have shown that smoking in middle age and beyond might increase the risk of dementia and blood vessel conditions. Quitting smoking might reduce the risk and improve health. […] Get enough vitamins. Some research suggests that people with low levels of vitamin D in their blood are more likely to develop Alzheimer’s disease and other forms of dementia. You can increase your vitamin D levels with certain foods, supplements and sun exposure.

• #93 Prevent Alzheimer’s Disease – Pillar 1: Diet and Supplements

  https://alzheimersprevention.org/4-pillars-of-prevention/pillar-1-diet-supplements/

  The ideal prevention diet breaks down like this: 20% good fats. Items in this group include extra virgin olive oil, avocado, and flax seed oil; 40% lean proteins. Look to include fish, chicken, turkey, and soy on a daily basis; 40% complex carbohydrates. Discover the rewards of a rainbow of fresh vegetables, whole grains, legumes, and fresh fruits; Superfoods for the brain as much as you want! These superfoods, including blueberries, spinach, and seaweed, have fabulous antioxidant properties preventing causes of Alzheimers. […] If youre serious about the prevention of Alzheimers and improving memory loss, you should definitely take a high potency multiple vitamin and mineral capsule. […] Folic acid reduces homocysteine levelshigh homocysteine levels put you at risk for both heart disease and memory loss. Vitamin C has been shown to reduce your risk of Alzheimers disease by 20% when taken with vitamin E.

• #94 Prevent Alzheimer’s Disease – Pillar 1: Diet and Supplements

  https://alzheimersprevention.org/4-pillars-of-prevention/pillar-1-diet-supplements/

  The ideal prevention diet breaks down like this: 20% good fats. Items in this group include extra virgin olive oil, avocado, and flax seed oil; 40% lean proteins. Look to include fish, chicken, turkey, and soy on a daily basis; 40% complex carbohydrates. Discover the rewards of a rainbow of fresh vegetables, whole grains, legumes, and fresh fruits; Superfoods for the brain as much as you want! These superfoods, including blueberries, spinach, and seaweed, have fabulous antioxidant properties preventing causes of Alzheimers. […] If youre serious about the prevention of Alzheimers and improving memory loss, you should definitely take a high potency multiple vitamin and mineral capsule. […] Folic acid reduces homocysteine levelshigh homocysteine levels put you at risk for both heart disease and memory loss. Vitamin C has been shown to reduce your risk of Alzheimers disease by 20% when taken with vitamin E.

• #95 Targeting 14 lifestyle factors may prevent up to 45% of dementia cases | Cognitive Vitality | Alzheimer’s Drug Discovery Foundation

  https://www.alzdiscovery.org/cognitive-vitality/blog/targeting-14-lifestyle-factors-may-prevent-up-to-45-of-dementia-cases

  People with depression have a higher risk of dementia than those without depression. […] Depression at all adult ages is associated with higher dementia risk, but the evidence is most clear for midlife depression. […] Traumatic brain injury is associated with a higher dementia risk, possibly leading to earlier onset of dementia by two to three years than in people without traumatic brain injury. […] Being physically active at all ages is associated with better cognition and lower dementia risk. […] Newer evidence suggests that the age of onset makes a difference, with a midlife onset of type 2 diabetes being significantly associated with higher dementia risk. […] Cigarettes and cigarette smoke contain more than 4,700 chemical compounds, including some that are highly toxic. […] Observational studies have shown that people who smoke are at a higher risk of developing all types of dementia and a much higher risk for Alzheimer’s disease.

• #96 Targeting 14 lifestyle factors may prevent up to 45% of dementia cases | Cognitive Vitality | Alzheimer’s Drug Discovery Foundation

  https://www.alzdiscovery.org/cognitive-vitality/blog/targeting-14-lifestyle-factors-may-prevent-up-to-45-of-dementia-cases

  People with depression have a higher risk of dementia than those without depression. […] Depression at all adult ages is associated with higher dementia risk, but the evidence is most clear for midlife depression. […] Traumatic brain injury is associated with a higher dementia risk, possibly leading to earlier onset of dementia by two to three years than in people without traumatic brain injury. […] Being physically active at all ages is associated with better cognition and lower dementia risk. […] Newer evidence suggests that the age of onset makes a difference, with a midlife onset of type 2 diabetes being significantly associated with higher dementia risk. […] Cigarettes and cigarette smoke contain more than 4,700 chemical compounds, including some that are highly toxic. […] Observational studies have shown that people who smoke are at a higher risk of developing all types of dementia and a much higher risk for Alzheimer’s disease.

• #97 Reducing Risk for Dementia | Alzheimer’s Disease and Dementia | CDC

  https://www.cdc.gov/alzheimers-dementia/prevention/index.html

  There are common conditions and lifestyle behaviors that can increase your risk for dementia. […] Learn what they are and the healthy lifestyle habits that can lower your risk of developing dementia, including Alzheimer’s disease. […] Nearly 45% of all dementia cases may be prevented or delayed. […] Small changes can make a big difference to lower your risk of dementia. […] Healthy habits can benefit brain health by: […] Reducing the chances of worsening memory loss. […] Slowing the progression of dementia, including Alzheimer’s. […] Regular physical activity can help you prevent, delay, or manage chronic diseases, like dementia. […] The good news is type 2 diabetes can be prevented or delayed. […] High blood pressure can damage blood vessels and limit blood flow to the brain, which does damage to the brain. […] Treating hearing loss (using hearing aids) may reduce the risk of dementia. […] If you drink alcohol, do so in moderation. […] Quit smoking to reduce your risk dementia. Quitting smoking also reduces other risks for dementia, like stroke, type 2 diabetes, and high blood pressure.

• #98 Targeting 14 lifestyle factors may prevent up to 45% of dementia cases | Cognitive Vitality | Alzheimer’s Drug Discovery Foundation

  https://www.alzdiscovery.org/cognitive-vitality/blog/targeting-14-lifestyle-factors-may-prevent-up-to-45-of-dementia-cases

  Studies suggest that having hypertension in midlife increases the risk of both vascular dementia and Alzheimer’s disease. […] People who are obese in midlife have an increased risk of dementia compared to those with healthy body weight. […] Heavy drinking is associated with cognitive impairment and dementia. […] Social isolation is a risk factor not only for dementia but also for hypertension, coronary heart disease, and depression. […] Many studies show that air pollution is a risk factor for dementia and cognitive impairment. […] An analysis of numerous cohort studies reported that vision impairment is associated with a higher risk of both dementia and cognitive impairment. […] The Lancet report is great news in that there are concrete steps you can take to reduce dementia risk. […] These recommendations are consistent with evidence from a seminal randomized controlled trial called FINGER that showed a group of lifestyle interventions that addressed many of these risk factors improved cognitive function in older people.

• #99 Prevention and Treatments for Dementia – Baptist Health

  https://www.baptisthealth.com/blog/baptist-health/prevention-and-treatments-for-dementia

  Dementia Prevention Techniques According to the Alzheimers Organization, there are many things you can do to reduce your risk of developing dementia and Alzheimers disease. Physical Activity. Exercising, such as walking, three or more times a week has been shown to reduce dementia risk. Avoid smoking. Smoking damages the heart and brain and contributes to the shrinking of the brain and increases dementia risk. Alcohol. Data shows a moderate amount of alcohol intake may reduce the risks of dementia, but regular over-consumption can triple the risk of dementia. Sleep. Regular, quality sleep reduces the risk of developing dementia. Diet. Reducing certain vitamin deficiencies and following an anti-inflammatory diet may reduce the development of dementia. […] The use of herbal remedies, dietary supplements, and certain foods to prevent and treat dementia have become increasingly popular. However, its important to note that little scientific research has been performed on these offerings, so you should be careful about using them if you choose to do so.

• #100 Reducing Risk for Dementia | Alzheimer’s Disease and Dementia | CDC

  https://www.cdc.gov/alzheimers-dementia/prevention/index.html

  There are common conditions and lifestyle behaviors that can increase your risk for dementia. […] Learn what they are and the healthy lifestyle habits that can lower your risk of developing dementia, including Alzheimer’s disease. […] Nearly 45% of all dementia cases may be prevented or delayed. […] Small changes can make a big difference to lower your risk of dementia. […] Healthy habits can benefit brain health by: […] Reducing the chances of worsening memory loss. […] Slowing the progression of dementia, including Alzheimer’s. […] Regular physical activity can help you prevent, delay, or manage chronic diseases, like dementia. […] The good news is type 2 diabetes can be prevented or delayed. […] High blood pressure can damage blood vessels and limit blood flow to the brain, which does damage to the brain. […] Treating hearing loss (using hearing aids) may reduce the risk of dementia. […] If you drink alcohol, do so in moderation. […] Quit smoking to reduce your risk dementia. Quitting smoking also reduces other risks for dementia, like stroke, type 2 diabetes, and high blood pressure.

• #101 Dementia – reducing your risk | Better Health Channel

  https://www.betterhealth.vic.gov.au/health/conditionsandtreatments/dementia-reducing-your-risk

  Although there are no guarantees that keeping your heart healthy will prevent dementia, you will give yourself the best chance of avoiding or delaying dementia. […] To reduce your risk of dementia, you should have regular check-ups with your doctor, especially at midlife, and always follow the advice of your doctor. […] Head injury, particularly severe injury (causing unconsciousness for an extended period of time) is a risk factor for the development of Alzheimers disease.

• #102 Targeting 14 lifestyle factors may prevent up to 45% of dementia cases | Cognitive Vitality | Alzheimer’s Drug Discovery Foundation

  https://www.alzdiscovery.org/cognitive-vitality/blog/targeting-14-lifestyle-factors-may-prevent-up-to-45-of-dementia-cases

  People with depression have a higher risk of dementia than those without depression. […] Depression at all adult ages is associated with higher dementia risk, but the evidence is most clear for midlife depression. […] Traumatic brain injury is associated with a higher dementia risk, possibly leading to earlier onset of dementia by two to three years than in people without traumatic brain injury. […] Being physically active at all ages is associated with better cognition and lower dementia risk. […] Newer evidence suggests that the age of onset makes a difference, with a midlife onset of type 2 diabetes being significantly associated with higher dementia risk. […] Cigarettes and cigarette smoke contain more than 4,700 chemical compounds, including some that are highly toxic. […] Observational studies have shown that people who smoke are at a higher risk of developing all types of dementia and a much higher risk for Alzheimer’s disease.

• #103 Alzheimer’s Association International Conference

  https://www.healio.com/news/psychiatry/20240731/eliminating-14-risk-factors-may-prevent-nearly-half-of-dementia-cases

  Eliminating these 14 risk factors may prevent nearly half of dementia cases. Tackling 14 risk factors for dementia beginning in childhood could prevent or delay nearly half of cases worldwide, according to a report from the Lancet Commission presented at the Alzheimer’s Association International Conference. These include two risk factors high cholesterol and vision loss newly identified by the commission on dementia prevention, intervention and care. If these 14 risk factors are eliminated, nearly half of dementias could theoretically be prevented, Livingston and colleagues wrote. Based on their findings, the researchers outlined 13 recommendations for individuals and governments to prevent dementia: ensure children have access to good-quality education and encourage individuals in midlife to participate in cognitively stimulating activities; reduce harmful noise exposure and make hearing aids accessible to those with hearing impairment; treat depression; promote helmets and other head protection during contact sports and when riding bicycles; encourage exercise; reduce smoking through education and by implementing policies that aim to control the cost of cigarettes; prevent or reduce high blood pressure; diagnose and treat high LDL; maintain a healthy weight and treat obesity early; reduce excessive alcohol use through price control and raising awareness about the risks of overconsumption; reduce social isolation by encouraging activities and living with other people, prioritizing an age-friendly and supportive community, environments and housing; ensure access to vision loss screening and treatment; and decrease air pollution exposure. Although addressing risk factors at an early stage of life is desirable, there is also benefit from tackling risk throughout life; it is never too early or too late to reduce dementia risk, Livingston and colleagues wrote.

• #104 Targeting 14 lifestyle factors may prevent up to 45% of dementia cases | Cognitive Vitality | Alzheimer’s Drug Discovery Foundation

  https://www.alzdiscovery.org/cognitive-vitality/blog/targeting-14-lifestyle-factors-may-prevent-up-to-45-of-dementia-cases

  Studies suggest that having hypertension in midlife increases the risk of both vascular dementia and Alzheimer’s disease. […] People who are obese in midlife have an increased risk of dementia compared to those with healthy body weight. […] Heavy drinking is associated with cognitive impairment and dementia. […] Social isolation is a risk factor not only for dementia but also for hypertension, coronary heart disease, and depression. […] Many studies show that air pollution is a risk factor for dementia and cognitive impairment. […] An analysis of numerous cohort studies reported that vision impairment is associated with a higher risk of both dementia and cognitive impairment. […] The Lancet report is great news in that there are concrete steps you can take to reduce dementia risk. […] These recommendations are consistent with evidence from a seminal randomized controlled trial called FINGER that showed a group of lifestyle interventions that addressed many of these risk factors improved cognitive function in older people.

• #105 Alzheimer’s Association International Conference

  https://www.healio.com/news/psychiatry/20240731/eliminating-14-risk-factors-may-prevent-nearly-half-of-dementia-cases

  Eliminating these 14 risk factors may prevent nearly half of dementia cases. Tackling 14 risk factors for dementia beginning in childhood could prevent or delay nearly half of cases worldwide, according to a report from the Lancet Commission presented at the Alzheimer’s Association International Conference. These include two risk factors high cholesterol and vision loss newly identified by the commission on dementia prevention, intervention and care. If these 14 risk factors are eliminated, nearly half of dementias could theoretically be prevented, Livingston and colleagues wrote. Based on their findings, the researchers outlined 13 recommendations for individuals and governments to prevent dementia: ensure children have access to good-quality education and encourage individuals in midlife to participate in cognitively stimulating activities; reduce harmful noise exposure and make hearing aids accessible to those with hearing impairment; treat depression; promote helmets and other head protection during contact sports and when riding bicycles; encourage exercise; reduce smoking through education and by implementing policies that aim to control the cost of cigarettes; prevent or reduce high blood pressure; diagnose and treat high LDL; maintain a healthy weight and treat obesity early; reduce excessive alcohol use through price control and raising awareness about the risks of overconsumption; reduce social isolation by encouraging activities and living with other people, prioritizing an age-friendly and supportive community, environments and housing; ensure access to vision loss screening and treatment; and decrease air pollution exposure. Although addressing risk factors at an early stage of life is desirable, there is also benefit from tackling risk throughout life; it is never too early or too late to reduce dementia risk, Livingston and colleagues wrote.

• #106 How to lower your dementia risk – Harvard Health

  https://www.health.harvard.edu/mind-and-mood/how-to-lower-your-dementia-risk

  During sleep, the brain clears out harmful beta-amyloid proteins. But the cleaning process can’t do a complete job if sleep is regularly disrupted by insomnia, sleep apnea, or other issues that cause you to wake during the night. „Eventually, this can cause or exacerbate abnormal protein buildup,” says Dr. Daneshvar. […] Another way to protect your brain from dementia is to socialize more. A study published online Oct. 24, 2023, by JAMA Neurology found that socially isolated older adults have a 27% higher chance of developing dementia than older adults who aren’t isolated. „Regular interactions activate mental processes, including attention and memory, which can bolster cognition,” says neuroscientist Dr. Daniel Daneshvar with Massachusetts General Hospital.

• #107 How to lower your dementia risk – Harvard Health

  https://www.health.harvard.edu/mind-and-mood/how-to-lower-your-dementia-risk

  During sleep, the brain clears out harmful beta-amyloid proteins. But the cleaning process can’t do a complete job if sleep is regularly disrupted by insomnia, sleep apnea, or other issues that cause you to wake during the night. „Eventually, this can cause or exacerbate abnormal protein buildup,” says Dr. Daneshvar. […] Another way to protect your brain from dementia is to socialize more. A study published online Oct. 24, 2023, by JAMA Neurology found that socially isolated older adults have a 27% higher chance of developing dementia than older adults who aren’t isolated. „Regular interactions activate mental processes, including attention and memory, which can bolster cognition,” says neuroscientist Dr. Daniel Daneshvar with Massachusetts General Hospital.

• #108 For Dementia Prevention, Sleep Quality in Midlife Matters More | UC San Francisco

  https://www.ucsf.edu/news/2023/12/426901/dementia-prevention-sleep-quality-midlife-matters-more

  A new study, led by UC San Francisco, reveals that quality of sleep, not quantity, may play a part in the development of dementia decades before symptoms start. […] Given the long, symptom-free window of Alzheimers disease and the high prevalence of sleep problems, the understanding of midlife sleep disturbances has significant public health implications. […] However, recent studies show that up to 40% of cases may be prevented or delayed by making health changes, including practicing good sleep hygiene. […] Future research is needed to study the link between sleep disturbances and cognition at different stages of life and to identify whether there are critical life periods when sleep is more strongly associated with cognition, added Yaffe, who is a member of the first team of experts to determine that 30% of dementia risk is preventable. This might open up new opportunities for the prevention of Alzheimers in late life.

• #109 Dementia Insights: Primary Prevention of Dementia

  https://practicalneurology.com/articles/2020-oct/dementia-insights-primary-prevention-of-dementia

  The USPSTF recommends clinicians ask all adults about tobacco use. […] The USPSTF is updating 2015 recommendations to screen for high blood pressure in adults age 18 years or more. […] Lifestyle modification is the first line of antihypertensive treatment, and the Dietary Approaches to Stop Hypertension (DASH) diet is effective in treating hypertension with an effect size comparable to drug monotherapy. […] There is currently insufficient evidence to determine the effectiveness of lipid-lowering treatment (statins) and diabetes treatment for preventing age-related cognitive decline or clinical Alzheimer type dementia; both are recognized priorities for future research. […] It is reasonable to counsel patients to increase intake of particular food groups, including vegetables, fruits, fish, olive oil, and nuts. […] It is reasonable to counsel patients to increase intake of vegetables, fruits, nuts, and fish, which have been found protective for cognition in observational studies. […] We recommend screening patients with cognitive impairment for sleep dysfunction.

• #110 Multi‐domain interventions for the prevention of dementia and cognitive decline – Hafdi, M – 2021 | Cochrane Library

  https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD013572.pub2/full

  Dementia is a worldwide concern. Its global prevalence is increasing. Currently, no effective medical treatment exists to cure or to delay the onset of cognitive decline or dementia. Up to 40% of dementia is attributable to potentially modifiable risk factors, which has led to the notion that targeting these risk factors might reduce the incidence of cognitive decline and dementia. Since sporadic dementia is a multifactorial condition, thought to derive from multiple causes and risk factors, multidomain interventions may be more effective for the prevention of dementia than those targeting single risk factors. […] To assess the effects of multidomain interventions for the prevention of cognitive decline and dementia in older adults, including both unselected populations and populations at increased risk of cognitive decline and dementia.

• #111 Multi‐domain interventions for the prevention of dementia and cognitive decline – Hafdi, M – 2021 | Cochrane Library

  https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD013572.pub2/full

  Dementia is a worldwide concern. Its global prevalence is increasing. Currently, no effective medical treatment exists to cure or to delay the onset of cognitive decline or dementia. Up to 40% of dementia is attributable to potentially modifiable risk factors, which has led to the notion that targeting these risk factors might reduce the incidence of cognitive decline and dementia. Since sporadic dementia is a multifactorial condition, thought to derive from multiple causes and risk factors, multidomain interventions may be more effective for the prevention of dementia than those targeting single risk factors. […] To assess the effects of multidomain interventions for the prevention of cognitive decline and dementia in older adults, including both unselected populations and populations at increased risk of cognitive decline and dementia.

• #112

  https://link.springer.com/article/10.14283/jpad.2024.12

  For instance, the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER)-study, a randomized controlled trial based on multimodal nonpharmacological lifestyle interventions, showed effectiveness for preventing dementia due to multimodal interventions and alongside health economic studies on cost-effectiveness of prevention of dementia have been published and indicated a cost-saving potential for prevention strategies. […] This review resulted in three main findings: (i) Prevention programs for preventing people at risk from developing dementia can be cost-effective and cost-saving, (ii) multimodal prevention interventions could be cost saving when the risk factors are defined alongside the evidence from WHO and LANCET, and (iii) there are some indications that life-style prevention in middle-age may be a good strategy for cost-effective prevention strategies. […] Concluding cost-effectiveness and even cost-saving potential due to multidomain interventions for prevention of dementia must be supported by further research and high-quality economic evaluations alongside good designed multicenter RCTs.

• #113

  https://link.springer.com/article/10.14283/jpad.2024.12

  For instance, the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER)-study, a randomized controlled trial based on multimodal nonpharmacological lifestyle interventions, showed effectiveness for preventing dementia due to multimodal interventions and alongside health economic studies on cost-effectiveness of prevention of dementia have been published and indicated a cost-saving potential for prevention strategies. […] This review resulted in three main findings: (i) Prevention programs for preventing people at risk from developing dementia can be cost-effective and cost-saving, (ii) multimodal prevention interventions could be cost saving when the risk factors are defined alongside the evidence from WHO and LANCET, and (iii) there are some indications that life-style prevention in middle-age may be a good strategy for cost-effective prevention strategies. […] Concluding cost-effectiveness and even cost-saving potential due to multidomain interventions for prevention of dementia must be supported by further research and high-quality economic evaluations alongside good designed multicenter RCTs.

• #114

  https://link.springer.com/article/10.14283/jpad.2024.12

  For instance, the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER)-study, a randomized controlled trial based on multimodal nonpharmacological lifestyle interventions, showed effectiveness for preventing dementia due to multimodal interventions and alongside health economic studies on cost-effectiveness of prevention of dementia have been published and indicated a cost-saving potential for prevention strategies. […] This review resulted in three main findings: (i) Prevention programs for preventing people at risk from developing dementia can be cost-effective and cost-saving, (ii) multimodal prevention interventions could be cost saving when the risk factors are defined alongside the evidence from WHO and LANCET, and (iii) there are some indications that life-style prevention in middle-age may be a good strategy for cost-effective prevention strategies. […] Concluding cost-effectiveness and even cost-saving potential due to multidomain interventions for prevention of dementia must be supported by further research and high-quality economic evaluations alongside good designed multicenter RCTs.

• #115

  https://link.springer.com/article/10.14283/jpad.2024.12

  For instance, the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER)-study, a randomized controlled trial based on multimodal nonpharmacological lifestyle interventions, showed effectiveness for preventing dementia due to multimodal interventions and alongside health economic studies on cost-effectiveness of prevention of dementia have been published and indicated a cost-saving potential for prevention strategies. […] This review resulted in three main findings: (i) Prevention programs for preventing people at risk from developing dementia can be cost-effective and cost-saving, (ii) multimodal prevention interventions could be cost saving when the risk factors are defined alongside the evidence from WHO and LANCET, and (iii) there are some indications that life-style prevention in middle-age may be a good strategy for cost-effective prevention strategies. […] Concluding cost-effectiveness and even cost-saving potential due to multidomain interventions for prevention of dementia must be supported by further research and high-quality economic evaluations alongside good designed multicenter RCTs.

• #116

  https://link.springer.com/article/10.14283/jpad.2024.12

  For instance, the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER)-study, a randomized controlled trial based on multimodal nonpharmacological lifestyle interventions, showed effectiveness for preventing dementia due to multimodal interventions and alongside health economic studies on cost-effectiveness of prevention of dementia have been published and indicated a cost-saving potential for prevention strategies. […] This review resulted in three main findings: (i) Prevention programs for preventing people at risk from developing dementia can be cost-effective and cost-saving, (ii) multimodal prevention interventions could be cost saving when the risk factors are defined alongside the evidence from WHO and LANCET, and (iii) there are some indications that life-style prevention in middle-age may be a good strategy for cost-effective prevention strategies. […] Concluding cost-effectiveness and even cost-saving potential due to multidomain interventions for prevention of dementia must be supported by further research and high-quality economic evaluations alongside good designed multicenter RCTs.

• #117 Targeting 14 lifestyle factors may prevent up to 45% of dementia cases | Cognitive Vitality | Alzheimer’s Drug Discovery Foundation

  https://www.alzdiscovery.org/cognitive-vitality/blog/targeting-14-lifestyle-factors-may-prevent-up-to-45-of-dementia-cases

  Studies suggest that having hypertension in midlife increases the risk of both vascular dementia and Alzheimer’s disease. […] People who are obese in midlife have an increased risk of dementia compared to those with healthy body weight. […] Heavy drinking is associated with cognitive impairment and dementia. […] Social isolation is a risk factor not only for dementia but also for hypertension, coronary heart disease, and depression. […] Many studies show that air pollution is a risk factor for dementia and cognitive impairment. […] An analysis of numerous cohort studies reported that vision impairment is associated with a higher risk of both dementia and cognitive impairment. […] The Lancet report is great news in that there are concrete steps you can take to reduce dementia risk. […] These recommendations are consistent with evidence from a seminal randomized controlled trial called FINGER that showed a group of lifestyle interventions that addressed many of these risk factors improved cognitive function in older people.

• #118 One third of dementia cases can be prevented within the next 25 years by tackling risk factors. The case “for” and “against” | Alzheimer’s Research & Therapy | Full Text

  https://alzres.biomedcentral.com/articles/10.1186/s13195-020-00646-x

  One third of dementia cases can be prevented within the next 25 years by tackling risk factors. Recently, it has been suggested that up to a third of the dementia cases might be preventable. This article revises the evidence for and against dementia primary prevention. Evidence for is sustained by the Lancet Commission on Dementia Prevention, Intervention and Care that noted a reduction of age-related incidence of dementia in high-income countries. Based on results from large cohort studies and using population attributable risk, the commission concluded that up to 35% of dementia cases could be prevented by modifying nine risk factors: low education, midlife hearing loss, obesity, hypertension, late-life depression, smoking, physical inactivity, diabetes, and social isolation. In this life course conceptual framework, modifications of risk factors can influence dementia decades before clinical disease onset. The Lancet Commission on Dementia Prevention, Intervention and Care Report suggest that, if nine potentially reversible risk factors are considered, up to a third of the dementia cases might be preventable. While prevention is always better than cure, this is particularly important in the field of dementia as it takes years for the AD pathology to accumulate. Multiple pathways are involved in the development of dementia which are theoretically treatable by managing midlife hearing loss and hypertension, and with physical exercise and education, as suggested by robust observational studies. However, evidence from large clinical trials is not conclusive to support that a third of dementia cases might be prevented. Pharmacological treatments for dementia have not yielded the results that we had hoped for. Observational evidence suggests that it is possible to delay progression to dementia with lifestyle interventions targeting 9 risk factors, as noted in a reduction of age-related incidence of dementia in high-income countries. Ultimately, since even relatively small reductions in dementia incidence would have a dramatic public health impact, one approach based on observational evidence is to encourage patients to be physically and cognitively active, maintain healthy diets, and to manage their hearing loss and cardiovascular risk factors, particularly hypertension. Current ongoing large lifestyle interventional trails, including those under the World Wide Finger initiative, may help to settle this debate.

• #119 Alzheimer’s Prevention

  https://centerforbrainhealth.org/alzheimers-discovery/alzheimers-prevention

  We applaud the Lancet Commissions detailed review and informative state-of-the-research review to upgrade brain care practices on dementia prevention, interventions, and care. Their enlightening synopsis reveals that 45% of dementia is potentially modifiable if we eliminate the noted risk factors. […] The 2024 update to the standing Lancet Commission on dementia prevention, intervention, and care adds two new risk factors (high LDL cholesterol and vision loss) and indicates that nearly half of all dementia cases worldwide could be prevented or delayed by addressing 14 modiable risk factors. […] The study underscores the importance of risk factors that exist at different stages of life, and creates urgency for adopting habits early in life, and beyond, to reduce risk and overall cases of dementia.

• #120 Alzheimer’s Association International Conference

  https://www.healio.com/news/psychiatry/20240731/eliminating-14-risk-factors-may-prevent-nearly-half-of-dementia-cases

  Eliminating these 14 risk factors may prevent nearly half of dementia cases. Tackling 14 risk factors for dementia beginning in childhood could prevent or delay nearly half of cases worldwide, according to a report from the Lancet Commission presented at the Alzheimer’s Association International Conference. These include two risk factors high cholesterol and vision loss newly identified by the commission on dementia prevention, intervention and care. If these 14 risk factors are eliminated, nearly half of dementias could theoretically be prevented, Livingston and colleagues wrote. Based on their findings, the researchers outlined 13 recommendations for individuals and governments to prevent dementia: ensure children have access to good-quality education and encourage individuals in midlife to participate in cognitively stimulating activities; reduce harmful noise exposure and make hearing aids accessible to those with hearing impairment; treat depression; promote helmets and other head protection during contact sports and when riding bicycles; encourage exercise; reduce smoking through education and by implementing policies that aim to control the cost of cigarettes; prevent or reduce high blood pressure; diagnose and treat high LDL; maintain a healthy weight and treat obesity early; reduce excessive alcohol use through price control and raising awareness about the risks of overconsumption; reduce social isolation by encouraging activities and living with other people, prioritizing an age-friendly and supportive community, environments and housing; ensure access to vision loss screening and treatment; and decrease air pollution exposure. Although addressing risk factors at an early stage of life is desirable, there is also benefit from tackling risk throughout life; it is never too early or too late to reduce dementia risk, Livingston and colleagues wrote.

• #121 Nearly half of dementia cases could be prevented or delayed by tackling 14 risk factors | UCL News – UCL – University College London

  https://www.ucl.ac.uk/news/2024/jul/nearly-half-dementia-cases-could-be-prevented-or-delayed-tackling-14-risk-factors

  Addressing 14 modifiable risk factors, starting in childhood and continuing throughout life, could prevent or delay nearly half of dementia cases, according to a new report led by UCL researchers. […] The Commission, authored by 27 world-leading dementia experts, calls for governments and individuals to be ambitious about tackling risks across the life course for dementia, arguing that the earlier we can address and reduce risk factor levels, the better. The report outlines a new set of policy and lifestyle changes to help prevent and better manage dementia. […] To reduce dementia risk throughout life, the Commission outlines 13 recommendations to be adopted by governments and individuals, including: Provide all children with good quality education and be cognitively active in midlife.

• #122 Alzheimer’s Association International Conference

  https://www.healio.com/news/psychiatry/20240731/eliminating-14-risk-factors-may-prevent-nearly-half-of-dementia-cases

  Eliminating these 14 risk factors may prevent nearly half of dementia cases. Tackling 14 risk factors for dementia beginning in childhood could prevent or delay nearly half of cases worldwide, according to a report from the Lancet Commission presented at the Alzheimer’s Association International Conference. These include two risk factors high cholesterol and vision loss newly identified by the commission on dementia prevention, intervention and care. If these 14 risk factors are eliminated, nearly half of dementias could theoretically be prevented, Livingston and colleagues wrote. Based on their findings, the researchers outlined 13 recommendations for individuals and governments to prevent dementia: ensure children have access to good-quality education and encourage individuals in midlife to participate in cognitively stimulating activities; reduce harmful noise exposure and make hearing aids accessible to those with hearing impairment; treat depression; promote helmets and other head protection during contact sports and when riding bicycles; encourage exercise; reduce smoking through education and by implementing policies that aim to control the cost of cigarettes; prevent or reduce high blood pressure; diagnose and treat high LDL; maintain a healthy weight and treat obesity early; reduce excessive alcohol use through price control and raising awareness about the risks of overconsumption; reduce social isolation by encouraging activities and living with other people, prioritizing an age-friendly and supportive community, environments and housing; ensure access to vision loss screening and treatment; and decrease air pollution exposure. Although addressing risk factors at an early stage of life is desirable, there is also benefit from tackling risk throughout life; it is never too early or too late to reduce dementia risk, Livingston and colleagues wrote.

• #123 Alzheimer’s Prevention

  https://centerforbrainhealth.org/alzheimers-discovery/alzheimers-prevention

  In 2024, revised findings now suggest that 45% – almost half – of dementia cases could be delayed or reduced by addressing 14 risk factors in early, middle and late life. […] If intensive lifestyle changes may cause improvement in cognition and function in MCI or early dementia due to AD, then it is reasonable to think that these lifestyle changes may also help to prevent them.

• #124 Targeting 14 lifestyle factors may prevent up to 45% of dementia cases | Cognitive Vitality | Alzheimer’s Drug Discovery Foundation

  https://www.alzdiscovery.org/cognitive-vitality/blog/targeting-14-lifestyle-factors-may-prevent-up-to-45-of-dementia-cases

  Studies suggest that having hypertension in midlife increases the risk of both vascular dementia and Alzheimer’s disease. […] People who are obese in midlife have an increased risk of dementia compared to those with healthy body weight. […] Heavy drinking is associated with cognitive impairment and dementia. […] Social isolation is a risk factor not only for dementia but also for hypertension, coronary heart disease, and depression. […] Many studies show that air pollution is a risk factor for dementia and cognitive impairment. […] An analysis of numerous cohort studies reported that vision impairment is associated with a higher risk of both dementia and cognitive impairment. […] The Lancet report is great news in that there are concrete steps you can take to reduce dementia risk. […] These recommendations are consistent with evidence from a seminal randomized controlled trial called FINGER that showed a group of lifestyle interventions that addressed many of these risk factors improved cognitive function in older people.

• #125 Targeting 14 lifestyle factors may prevent up to 45% of dementia cases | Cognitive Vitality | Alzheimer’s Drug Discovery Foundation

  https://www.alzdiscovery.org/cognitive-vitality/blog/targeting-14-lifestyle-factors-may-prevent-up-to-45-of-dementia-cases

  Studies suggest that having hypertension in midlife increases the risk of both vascular dementia and Alzheimer’s disease. […] People who are obese in midlife have an increased risk of dementia compared to those with healthy body weight. […] Heavy drinking is associated with cognitive impairment and dementia. […] Social isolation is a risk factor not only for dementia but also for hypertension, coronary heart disease, and depression. […] Many studies show that air pollution is a risk factor for dementia and cognitive impairment. […] An analysis of numerous cohort studies reported that vision impairment is associated with a higher risk of both dementia and cognitive impairment. […] The Lancet report is great news in that there are concrete steps you can take to reduce dementia risk. […] These recommendations are consistent with evidence from a seminal randomized controlled trial called FINGER that showed a group of lifestyle interventions that addressed many of these risk factors improved cognitive function in older people.

• #126 Physical activity and the risk of dementia | Alzheimer’s Society

  https://www.alzheimers.org.uk/about-dementia/managing-the-risk-of-dementia/reduce-your-risk-of-dementia/physical-activity

  Regular physical activity is one of the best things that you can do to reduce your risk of developing dementia. […] A lack of physical exercise is one of the main factors where the evidence is strong enough to show that it increases a persons risk of developing dementia. […] A lifelong approach to good health is the best way to lower your risk of dementia. […] There are some lifestyle behaviours with enough evidence to show that changing them will reduce your risk of dementia. […] Research has shown that people who take regular exercise may be up to 20% less likely to develop dementia than those who don’t take regular exercise. […] Sustaining physical activity throughout midlife also seems to have the best effect on reducing dementia risk. […] There is some evidence to show older people can also reduce their risk of dementia with regular exercise.

• #127 Targeting 14 lifestyle factors may prevent up to 45% of dementia cases | Cognitive Vitality | Alzheimer’s Drug Discovery Foundation

  https://www.alzdiscovery.org/cognitive-vitality/blog/targeting-14-lifestyle-factors-may-prevent-up-to-45-of-dementia-cases

  Targeting 14 lifestyle factors may prevent up to 45% of dementia cases. […] In July 2024, the Lancet Commission added two new risk factors and reported that 45% of dementia cases could be prevented by fully addressing 14 lifestyle factors. […] Not completing secondary education increases your risk of dementia. […] Lifelong learning is associated with improved brain health, and higher levels of cognitive activity at mid- or late-life are linked to delayed onset of cognitive impairment. […] Many high-quality observational studies suggest an association between hearing loss and subsequent dementia. […] Studies have found that with every 10-dB decrease in hearing ability, there is a 4 to 24% higher risk of dementia. […] High LDL cholesterol in midlife is associated with a higher risk of dementia.

• #128 Targeting 14 lifestyle factors may prevent up to 45% of dementia cases | Cognitive Vitality | Alzheimer’s Drug Discovery Foundation

  https://www.alzdiscovery.org/cognitive-vitality/blog/targeting-14-lifestyle-factors-may-prevent-up-to-45-of-dementia-cases

  Targeting 14 lifestyle factors may prevent up to 45% of dementia cases. […] In July 2024, the Lancet Commission added two new risk factors and reported that 45% of dementia cases could be prevented by fully addressing 14 lifestyle factors. […] Not completing secondary education increases your risk of dementia. […] Lifelong learning is associated with improved brain health, and higher levels of cognitive activity at mid- or late-life are linked to delayed onset of cognitive impairment. […] Many high-quality observational studies suggest an association between hearing loss and subsequent dementia. […] Studies have found that with every 10-dB decrease in hearing ability, there is a 4 to 24% higher risk of dementia. […] High LDL cholesterol in midlife is associated with a higher risk of dementia.

• #129 Nearly half of dementia cases could be prevented or delayed by tackling 14 risk factors | UCL News – UCL – University College London

  https://www.ucl.ac.uk/news/2024/jul/nearly-half-dementia-cases-could-be-prevented-or-delayed-tackling-14-risk-factors

  Addressing 14 modifiable risk factors, starting in childhood and continuing throughout life, could prevent or delay nearly half of dementia cases, according to a new report led by UCL researchers. […] The Commission, authored by 27 world-leading dementia experts, calls for governments and individuals to be ambitious about tackling risks across the life course for dementia, arguing that the earlier we can address and reduce risk factor levels, the better. The report outlines a new set of policy and lifestyle changes to help prevent and better manage dementia. […] To reduce dementia risk throughout life, the Commission outlines 13 recommendations to be adopted by governments and individuals, including: Provide all children with good quality education and be cognitively active in midlife.

• #130 Targeting 14 lifestyle factors may prevent up to 45% of dementia cases | Cognitive Vitality | Alzheimer’s Drug Discovery Foundation

  https://www.alzdiscovery.org/cognitive-vitality/blog/targeting-14-lifestyle-factors-may-prevent-up-to-45-of-dementia-cases

  Studies suggest that having hypertension in midlife increases the risk of both vascular dementia and Alzheimer’s disease. […] People who are obese in midlife have an increased risk of dementia compared to those with healthy body weight. […] Heavy drinking is associated with cognitive impairment and dementia. […] Social isolation is a risk factor not only for dementia but also for hypertension, coronary heart disease, and depression. […] Many studies show that air pollution is a risk factor for dementia and cognitive impairment. […] An analysis of numerous cohort studies reported that vision impairment is associated with a higher risk of both dementia and cognitive impairment. […] The Lancet report is great news in that there are concrete steps you can take to reduce dementia risk. […] These recommendations are consistent with evidence from a seminal randomized controlled trial called FINGER that showed a group of lifestyle interventions that addressed many of these risk factors improved cognitive function in older people.

• #131 Targeting 14 lifestyle factors may prevent up to 45% of dementia cases | Cognitive Vitality | Alzheimer’s Drug Discovery Foundation

  https://www.alzdiscovery.org/cognitive-vitality/blog/targeting-14-lifestyle-factors-may-prevent-up-to-45-of-dementia-cases

  People with depression have a higher risk of dementia than those without depression. […] Depression at all adult ages is associated with higher dementia risk, but the evidence is most clear for midlife depression. […] Traumatic brain injury is associated with a higher dementia risk, possibly leading to earlier onset of dementia by two to three years than in people without traumatic brain injury. […] Being physically active at all ages is associated with better cognition and lower dementia risk. […] Newer evidence suggests that the age of onset makes a difference, with a midlife onset of type 2 diabetes being significantly associated with higher dementia risk. […] Cigarettes and cigarette smoke contain more than 4,700 chemical compounds, including some that are highly toxic. […] Observational studies have shown that people who smoke are at a higher risk of developing all types of dementia and a much higher risk for Alzheimer’s disease.

• #132 Targeting 14 lifestyle factors may prevent up to 45% of dementia cases | Cognitive Vitality | Alzheimer’s Drug Discovery Foundation

  https://www.alzdiscovery.org/cognitive-vitality/blog/targeting-14-lifestyle-factors-may-prevent-up-to-45-of-dementia-cases

  People with depression have a higher risk of dementia than those without depression. […] Depression at all adult ages is associated with higher dementia risk, but the evidence is most clear for midlife depression. […] Traumatic brain injury is associated with a higher dementia risk, possibly leading to earlier onset of dementia by two to three years than in people without traumatic brain injury. […] Being physically active at all ages is associated with better cognition and lower dementia risk. […] Newer evidence suggests that the age of onset makes a difference, with a midlife onset of type 2 diabetes being significantly associated with higher dementia risk. […] Cigarettes and cigarette smoke contain more than 4,700 chemical compounds, including some that are highly toxic. […] Observational studies have shown that people who smoke are at a higher risk of developing all types of dementia and a much higher risk for Alzheimer’s disease.

• #133 Targeting 14 lifestyle factors may prevent up to 45% of dementia cases | Cognitive Vitality | Alzheimer’s Drug Discovery Foundation

  https://www.alzdiscovery.org/cognitive-vitality/blog/targeting-14-lifestyle-factors-may-prevent-up-to-45-of-dementia-cases

  People with depression have a higher risk of dementia than those without depression. […] Depression at all adult ages is associated with higher dementia risk, but the evidence is most clear for midlife depression. […] Traumatic brain injury is associated with a higher dementia risk, possibly leading to earlier onset of dementia by two to three years than in people without traumatic brain injury. […] Being physically active at all ages is associated with better cognition and lower dementia risk. […] Newer evidence suggests that the age of onset makes a difference, with a midlife onset of type 2 diabetes being significantly associated with higher dementia risk. […] Cigarettes and cigarette smoke contain more than 4,700 chemical compounds, including some that are highly toxic. […] Observational studies have shown that people who smoke are at a higher risk of developing all types of dementia and a much higher risk for Alzheimer’s disease.

• #134 Targeting 14 lifestyle factors may prevent up to 45% of dementia cases | Cognitive Vitality | Alzheimer’s Drug Discovery Foundation

  https://www.alzdiscovery.org/cognitive-vitality/blog/targeting-14-lifestyle-factors-may-prevent-up-to-45-of-dementia-cases

  People with depression have a higher risk of dementia than those without depression. […] Depression at all adult ages is associated with higher dementia risk, but the evidence is most clear for midlife depression. […] Traumatic brain injury is associated with a higher dementia risk, possibly leading to earlier onset of dementia by two to three years than in people without traumatic brain injury. […] Being physically active at all ages is associated with better cognition and lower dementia risk. […] Newer evidence suggests that the age of onset makes a difference, with a midlife onset of type 2 diabetes being significantly associated with higher dementia risk. […] Cigarettes and cigarette smoke contain more than 4,700 chemical compounds, including some that are highly toxic. […] Observational studies have shown that people who smoke are at a higher risk of developing all types of dementia and a much higher risk for Alzheimer’s disease.

• #135 Targeting 14 lifestyle factors may prevent up to 45% of dementia cases | Cognitive Vitality | Alzheimer’s Drug Discovery Foundation

  https://www.alzdiscovery.org/cognitive-vitality/blog/targeting-14-lifestyle-factors-may-prevent-up-to-45-of-dementia-cases

  Studies suggest that having hypertension in midlife increases the risk of both vascular dementia and Alzheimer’s disease. […] People who are obese in midlife have an increased risk of dementia compared to those with healthy body weight. […] Heavy drinking is associated with cognitive impairment and dementia. […] Social isolation is a risk factor not only for dementia but also for hypertension, coronary heart disease, and depression. […] Many studies show that air pollution is a risk factor for dementia and cognitive impairment. […] An analysis of numerous cohort studies reported that vision impairment is associated with a higher risk of both dementia and cognitive impairment. […] The Lancet report is great news in that there are concrete steps you can take to reduce dementia risk. […] These recommendations are consistent with evidence from a seminal randomized controlled trial called FINGER that showed a group of lifestyle interventions that addressed many of these risk factors improved cognitive function in older people.

• #136

  https://journals.publishing.umich.edu/ujph/article/id/3946/

  Secondary prevention aims to target the pre-symptomatic or preclinical stage and prevent the development of Alzheimers symptoms through the appropriate use of screening and early diagnostic tools, including biomarkers, scalable screening technologies, and cognitive assessments, followed by prompt treatment. […] Tertiary prevention aims to target the clinical stage and the disability stage when primary prevention and secondary prevention are unsuccessful. […] The goal of tertiary prevention is to increase life expectancy and quality of life, improve well-being, prevent complications of Alzheimers, and limit disability and immobility. […] Successful Alzheimers management requires open physician, caregiver, and patient communication, behavioral approaches, caregiver support, and pharmacological interventions.

• #137

  https://journals.publishing.umich.edu/ujph/article/id/3946/

  Secondary prevention aims to target the pre-symptomatic or preclinical stage and prevent the development of Alzheimers symptoms through the appropriate use of screening and early diagnostic tools, including biomarkers, scalable screening technologies, and cognitive assessments, followed by prompt treatment. […] Tertiary prevention aims to target the clinical stage and the disability stage when primary prevention and secondary prevention are unsuccessful. […] The goal of tertiary prevention is to increase life expectancy and quality of life, improve well-being, prevent complications of Alzheimers, and limit disability and immobility. […] Successful Alzheimers management requires open physician, caregiver, and patient communication, behavioral approaches, caregiver support, and pharmacological interventions.

• #138 Prevention | Alzheimer’s Drug Discovery Foundation

  https://www.alzdiscovery.org/research-and-grants/funding-opportunities/prevention-pipeline

  The ADDF seeks to support precision prevention studies, combination therapy studies, and comparative effectiveness research that probe whether the use or choice of interventions may reduce the risk of Alzheimers disease or other dementias. […] Primary Prevention studies include people without biomarker evidence of dementia pathology or dementia symptoms but who have specific risk factors for dementia. […] Secondary Prevention studies include people with biomarker evidence of dementia pathology who do not yet have dementia symptoms. […] In July 2024, the Lancet Commission on Dementia Prevention, Intervention and Care reported that 45% of dementia cases may be prevented by fully addressing 14 modifiable risk factors. […] Dementia risk reduction through Precision Prevention can be achieved with a targeted, mechanism-specific preventative intervention in specific populations who are at risk for developing dementia due to these risk factors and/or genetic risk factors, such as APOE4, as well as other medical conditions linked to dementia risk, including postoperative delirium/cognitive decline, menopause-related cognitive symptoms, chemotherapy-induced decline, and long COVID-19.

• #139

  https://journals.publishing.umich.edu/ujph/article/id/3946/

  Secondary prevention aims to target the pre-symptomatic or preclinical stage and prevent the development of Alzheimers symptoms through the appropriate use of screening and early diagnostic tools, including biomarkers, scalable screening technologies, and cognitive assessments, followed by prompt treatment. […] Tertiary prevention aims to target the clinical stage and the disability stage when primary prevention and secondary prevention are unsuccessful. […] The goal of tertiary prevention is to increase life expectancy and quality of life, improve well-being, prevent complications of Alzheimers, and limit disability and immobility. […] Successful Alzheimers management requires open physician, caregiver, and patient communication, behavioral approaches, caregiver support, and pharmacological interventions.

• #140

  https://journals.publishing.umich.edu/ujph/article/id/3946/

  Secondary prevention aims to target the pre-symptomatic or preclinical stage and prevent the development of Alzheimers symptoms through the appropriate use of screening and early diagnostic tools, including biomarkers, scalable screening technologies, and cognitive assessments, followed by prompt treatment. […] Tertiary prevention aims to target the clinical stage and the disability stage when primary prevention and secondary prevention are unsuccessful. […] The goal of tertiary prevention is to increase life expectancy and quality of life, improve well-being, prevent complications of Alzheimers, and limit disability and immobility. […] Successful Alzheimers management requires open physician, caregiver, and patient communication, behavioral approaches, caregiver support, and pharmacological interventions.

• #141

  https://journals.publishing.umich.edu/ujph/article/id/3946/

  Secondary prevention aims to target the pre-symptomatic or preclinical stage and prevent the development of Alzheimers symptoms through the appropriate use of screening and early diagnostic tools, including biomarkers, scalable screening technologies, and cognitive assessments, followed by prompt treatment. […] Tertiary prevention aims to target the clinical stage and the disability stage when primary prevention and secondary prevention are unsuccessful. […] The goal of tertiary prevention is to increase life expectancy and quality of life, improve well-being, prevent complications of Alzheimers, and limit disability and immobility. […] Successful Alzheimers management requires open physician, caregiver, and patient communication, behavioral approaches, caregiver support, and pharmacological interventions.

• #142

  https://journals.publishing.umich.edu/ujph/article/id/3946/

  Secondary prevention aims to target the pre-symptomatic or preclinical stage and prevent the development of Alzheimers symptoms through the appropriate use of screening and early diagnostic tools, including biomarkers, scalable screening technologies, and cognitive assessments, followed by prompt treatment. […] Tertiary prevention aims to target the clinical stage and the disability stage when primary prevention and secondary prevention are unsuccessful. […] The goal of tertiary prevention is to increase life expectancy and quality of life, improve well-being, prevent complications of Alzheimers, and limit disability and immobility. […] Successful Alzheimers management requires open physician, caregiver, and patient communication, behavioral approaches, caregiver support, and pharmacological interventions.

• #143

  https://journals.publishing.umich.edu/ujph/article/id/3946/

  Although current pharmacological interventions cannot stop or reverse Alzheimers disease progression, they can temporarily improve symptoms. […] According to the 2020 report of the Lancet Commission, tertiary prevention interventions that benefit Alzheimers patients include physical activity, cognitive training, psychosocial management of treatment and care, discussions with a psychiatrist or neurologist, and telemedicine.

• #144

  https://journals.publishing.umich.edu/ujph/article/id/3946/

  Although current pharmacological interventions cannot stop or reverse Alzheimers disease progression, they can temporarily improve symptoms. […] According to the 2020 report of the Lancet Commission, tertiary prevention interventions that benefit Alzheimers patients include physical activity, cognitive training, psychosocial management of treatment and care, discussions with a psychiatrist or neurologist, and telemedicine.

• #145

  https://journals.publishing.umich.edu/ujph/article/id/3946/

  Although current pharmacological interventions cannot stop or reverse Alzheimers disease progression, they can temporarily improve symptoms. […] According to the 2020 report of the Lancet Commission, tertiary prevention interventions that benefit Alzheimers patients include physical activity, cognitive training, psychosocial management of treatment and care, discussions with a psychiatrist or neurologist, and telemedicine.

• #146

  https://journals.publishing.umich.edu/ujph/article/id/3946/

  Although current pharmacological interventions cannot stop or reverse Alzheimers disease progression, they can temporarily improve symptoms. […] According to the 2020 report of the Lancet Commission, tertiary prevention interventions that benefit Alzheimers patients include physical activity, cognitive training, psychosocial management of treatment and care, discussions with a psychiatrist or neurologist, and telemedicine.

• #147

  https://journals.publishing.umich.edu/ujph/article/id/3946/

  Although current pharmacological interventions cannot stop or reverse Alzheimers disease progression, they can temporarily improve symptoms. […] According to the 2020 report of the Lancet Commission, tertiary prevention interventions that benefit Alzheimers patients include physical activity, cognitive training, psychosocial management of treatment and care, discussions with a psychiatrist or neurologist, and telemedicine.

• #148 Dementia Prevention and Treatment: A Narrative Review – PubMed

  https://pubmed.ncbi.nlm.nih.gov/38436963/

  Dementia affects 10% of those 65 years or older and 35% of those 90 years or older, often with profound cognitive, behavioral, and functional consequences. […] Preventive measures are aimed at modifiable risk factors, many of which have been identified. […] To date, no randomized clinical trial data conclusively confirm that interventions of any kind can prevent dementia. […] Nevertheless, addressing risk factors may have other health benefits and should be considered. […] Several emerging prevention and treatment strategies hold promise to improve dementia care in the future. […] Although current prevention and treatment approaches to dementia have been less than optimally successful, substantial investments in dementia research will undoubtedly provide new answers to reducing the burden of dementia worldwide.

• #149 Anti-amyloid drug shows signs of preventing Alzheimer’s dementia – WashU Medicine

  https://medicine.washu.edu/news/anti-amyloid-drug-shows-signs-of-preventing-alzheimers-dementia/

  Clinical trial of people destined to develop early-onset Alzheimers disease shows eliminating amyloid from brain may prevent symptoms, supports need for confirmatory studies […] An experimental drug appears to reduce the risk of Alzheimers-related dementia in people destined to develop the disease in their 30s, 40s or 50s, according to the results of a study led by the Knight Family Dominantly Inherited Alzheimer Network-Trials Unit (DIAN-TU), which is based at Washington University School of Medicine in St. Louis. The findings suggest for the first time in a clinical trial that early treatment to remove amyloid plaques from the brain many years before symptoms arise can delay the onset of Alzheimers dementia. […] In order to give them the best opportunity to stay cognitively normal, we have continued treatment with another anti-amyloid antibody in hopes they will never develop symptoms at all. What we do know is that its possible at least to delay the onset of the symptoms of Alzheimers disease and give people more years of healthy life.

• #150 Anti-amyloid drug shows signs of preventing Alzheimer’s dementia – WashU Medicine

  https://medicine.washu.edu/news/anti-amyloid-drug-shows-signs-of-preventing-alzheimers-dementia/

  Clinical trial of people destined to develop early-onset Alzheimers disease shows eliminating amyloid from brain may prevent symptoms, supports need for confirmatory studies […] An experimental drug appears to reduce the risk of Alzheimers-related dementia in people destined to develop the disease in their 30s, 40s or 50s, according to the results of a study led by the Knight Family Dominantly Inherited Alzheimer Network-Trials Unit (DIAN-TU), which is based at Washington University School of Medicine in St. Louis. The findings suggest for the first time in a clinical trial that early treatment to remove amyloid plaques from the brain many years before symptoms arise can delay the onset of Alzheimers dementia. […] In order to give them the best opportunity to stay cognitively normal, we have continued treatment with another anti-amyloid antibody in hopes they will never develop symptoms at all. What we do know is that its possible at least to delay the onset of the symptoms of Alzheimers disease and give people more years of healthy life.

• #151 Anti-amyloid drug shows signs of preventing Alzheimer’s dementia – WashU Medicine

  https://medicine.washu.edu/news/anti-amyloid-drug-shows-signs-of-preventing-alzheimers-dementia/

  The findings provide new evidence to support the so-called amyloid hypothesis of Alzheimers disease, which posits that the first step on the road to dementia is the build-up of amyloid plaques in the brain, and that removing such plaques or blocking their formation can stop symptoms from arising. […] Analysis of this data set revealed that removal of brain amyloid plaques years before symptoms are expected to arise delayed symptom onset and dementia progression, although the results were only statistically significant for the subgroup of people who started with no symptoms and were treated the longest. […] If late-onset Alzheimers prevention trials have similar results to the DIAN-TU trials, there soon could be Alzheimers preventions available for the general population, Bateman said. I am highly optimistic now, as this could be the first clinical evidence of what will become preventions for people at risk for Alzheimers disease. One day soon, we may be delaying the onset of Alzheimers disease for millions.

• #152 Study strengthens link between shingles vaccine and lower dementia risk

  https://med.stanford.edu/news/all-news/2025/03/shingles-vaccination-dementia.html

  A new analysis of a vaccination program in Wales found that the shingles vaccine appeared to lower new dementia diagnoses by 20% more than any other known intervention. […] In a new study led by Stanford Medicine, researchers analyzing the health records of Welsh older adults discovered that those who received the shingles vaccine were 20% less likely to develop dementia over the next seven years than those who did not receive the vaccine. […] If further confirmed, the new findings suggest that a preventive intervention for dementia is already close at hand. […] By 2020, one in eight older adults, who were by then 86 and 87, had been diagnosed with dementia. But those who received the shingles vaccine were 20% less likely to develop dementia than the unvaccinated. […] The only difference was the drop in dementia diagnoses.

• #153 Study strengthens link between shingles vaccine and lower dementia risk

  https://med.stanford.edu/news/all-news/2025/03/shingles-vaccination-dementia.html

  A new analysis of a vaccination program in Wales found that the shingles vaccine appeared to lower new dementia diagnoses by 20% more than any other known intervention. […] In a new study led by Stanford Medicine, researchers analyzing the health records of Welsh older adults discovered that those who received the shingles vaccine were 20% less likely to develop dementia over the next seven years than those who did not receive the vaccine. […] If further confirmed, the new findings suggest that a preventive intervention for dementia is already close at hand. […] By 2020, one in eight older adults, who were by then 86 and 87, had been diagnosed with dementia. But those who received the shingles vaccine were 20% less likely to develop dementia than the unvaccinated. […] The only difference was the drop in dementia diagnoses.

• #154 Dementia Prevention and Treatment: A Narrative Review – PubMed

  https://pubmed.ncbi.nlm.nih.gov/38436963/

  Dementia affects 10% of those 65 years or older and 35% of those 90 years or older, often with profound cognitive, behavioral, and functional consequences. […] Preventive measures are aimed at modifiable risk factors, many of which have been identified. […] To date, no randomized clinical trial data conclusively confirm that interventions of any kind can prevent dementia. […] Nevertheless, addressing risk factors may have other health benefits and should be considered. […] Several emerging prevention and treatment strategies hold promise to improve dementia care in the future. […] Although current prevention and treatment approaches to dementia have been less than optimally successful, substantial investments in dementia research will undoubtedly provide new answers to reducing the burden of dementia worldwide.

• #155 Dementia prevention needs clinical trials | Nature Medicine

  https://www.nature.com/articles/s41591-025-03552-7

  Interventions focused on disease prevention are a promising strategy for combating the rising incidence of dementia, but more evidence from clinical trials is needed to establish their feasibility and effectiveness. […] A growing body of evidence links dementia risk to several modifiable factors, including lifestyle choices. […] However, data from randomized controlled trials (RCTs) on the effectiveness of these interventions are limited and often yield mixed results, posing a considerable challenge to the development of evidence-based prevention strategies. […] There is compelling evidence to support efforts to address various risk factors for dementia. […] The 2024 update of the Lancet Commission on dementia underscores the high potential for prevention, suggesting that nearly half of all dementia cases could theoretically be prevented by mitigating 14 risk factors.

• #156 Dementia Insights: Primary Prevention of Dementia

  https://practicalneurology.com/articles/2020-oct/dementia-insights-primary-prevention-of-dementia

  Behavioral counseling to promote a healthy diet and physical activity is recommended for adults who are overweight or obese and also have cardiovascular risk factors. […] Physical activity promotes recovery after ischemic insult, and neuronal survival after neurotoxic injury in animal models. […] The World Health Organization recommends 150 minutes of moderate-intensity or 75 minutes of vigorous-intensity aerobic activity per week for adults ages 18 to 64 and suggests additional benefits from doubling the weekly duration of activity. […] A systematic review of 19 randomized clinical trials concluded there is encouraging but inconclusive evidence that physical activity may delay or slow age-related cognitive decline and insufficient evidence of whether physical activity prevents or delays clinical Alzheimer-type dementia.

• #157 Evidence-Based Prevention – Alzheimer’s Disease Research Center

  http://depts.washington.edu/mbwc/adrc/page/prevention

  2020 findings from the SPRINT-MIND study found that lowering blood pressure to under 120 showed a 19% reduction in those participants who went on to develop dementia during the study. […] In terms of brain and cognitive health, the best data support the Mediterranean diet, which includes relatively little red meat and emphasizes whole grains, fruits and vegetables, fish and shellfish, and nuts, olive oil and other healthy fats. […] A study published in Alzheimer’s Dementia of 923 adults aged 58-98 who maintained the MIND diet for 4.5 years showed a 53% reduction in the incidence of Alzheimer’s disease dementia. […] An NIH-funded study found that eating a Mediterranean diet slows some changes in the brain that may indicate early Alzheimers disease. […] According to UW MBWC’s Dr. Kristoffer Rhoads mindfulness meditation can boost memory and improve brain connections in people with mild cognitive impairment (MCI) and early stage dementia.

• #158 Dementia – Symptoms and causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/dementia/symptoms-causes/syc-20352013

  Manage cardiovascular risk factors. Treat high blood pressure, high cholesterol and diabetes. Pay attention to your levels of LDL cholesterol and get treatment if the levels are too high. High levels of LDL in middle age raises the risk of dementia. Lose weight if you’re overweight. […] Treat health conditions. See your doctor for treatment of depression or anxiety. […] Maintain a healthy diet. A diet such as the Mediterranean diet might promote health and lower the risk of developing dementia. A Mediterranean diet is rich in fruits, vegetables, whole grains and omega-3 fatty acids, which are commonly found in certain fish and nuts. This type of diet also improves cardiovascular health, which also may help lower dementia risk. […] Get good-quality sleep. Practice good sleep hygiene. Talk to a health care professional if you snore loudly or have periods where you stop breathing or gasp during sleep.

• #159 Dementia – Symptoms and causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/dementia/symptoms-causes/syc-20352013

  Treat hearing loss. People with hearing loss have a greater chance of developing problems with thinking, known as cognitive decline. Early treatment of hearing loss, such as use of hearing aids, might help decrease the risk. […] Get regular eye exams and treat vision loss. Research suggests that not treating vision loss may be associated with a raised risk of dementia.

• #160 How to lower your dementia risk – Harvard Health

  https://www.health.harvard.edu/mind-and-mood/how-to-lower-your-dementia-risk

  During sleep, the brain clears out harmful beta-amyloid proteins. But the cleaning process can’t do a complete job if sleep is regularly disrupted by insomnia, sleep apnea, or other issues that cause you to wake during the night. „Eventually, this can cause or exacerbate abnormal protein buildup,” says Dr. Daneshvar. […] Another way to protect your brain from dementia is to socialize more. A study published online Oct. 24, 2023, by JAMA Neurology found that socially isolated older adults have a 27% higher chance of developing dementia than older adults who aren’t isolated. „Regular interactions activate mental processes, including attention and memory, which can bolster cognition,” says neuroscientist Dr. Daniel Daneshvar with Massachusetts General Hospital.

• #161 Reducing Risk for Dementia | Alzheimer’s Disease and Dementia | CDC

  https://www.cdc.gov/alzheimers-dementia/prevention/index.html

  There are common conditions and lifestyle behaviors that can increase your risk for dementia. […] Learn what they are and the healthy lifestyle habits that can lower your risk of developing dementia, including Alzheimer’s disease. […] Nearly 45% of all dementia cases may be prevented or delayed. […] Small changes can make a big difference to lower your risk of dementia. […] Healthy habits can benefit brain health by: […] Reducing the chances of worsening memory loss. […] Slowing the progression of dementia, including Alzheimer’s. […] Regular physical activity can help you prevent, delay, or manage chronic diseases, like dementia. […] The good news is type 2 diabetes can be prevented or delayed. […] High blood pressure can damage blood vessels and limit blood flow to the brain, which does damage to the brain. […] Treating hearing loss (using hearing aids) may reduce the risk of dementia. […] If you drink alcohol, do so in moderation. […] Quit smoking to reduce your risk dementia. Quitting smoking also reduces other risks for dementia, like stroke, type 2 diabetes, and high blood pressure.

• #162 How to lower your dementia risk – Harvard Health

  https://www.health.harvard.edu/mind-and-mood/how-to-lower-your-dementia-risk

  During sleep, the brain clears out harmful beta-amyloid proteins. But the cleaning process can’t do a complete job if sleep is regularly disrupted by insomnia, sleep apnea, or other issues that cause you to wake during the night. „Eventually, this can cause or exacerbate abnormal protein buildup,” says Dr. Daneshvar. […] Another way to protect your brain from dementia is to socialize more. A study published online Oct. 24, 2023, by JAMA Neurology found that socially isolated older adults have a 27% higher chance of developing dementia than older adults who aren’t isolated. „Regular interactions activate mental processes, including attention and memory, which can bolster cognition,” says neuroscientist Dr. Daniel Daneshvar with Massachusetts General Hospital.

• #163 Alzheimer’s Association International Conference

  https://www.healio.com/news/psychiatry/20240731/eliminating-14-risk-factors-may-prevent-nearly-half-of-dementia-cases

  Eliminating these 14 risk factors may prevent nearly half of dementia cases. Tackling 14 risk factors for dementia beginning in childhood could prevent or delay nearly half of cases worldwide, according to a report from the Lancet Commission presented at the Alzheimer’s Association International Conference. These include two risk factors high cholesterol and vision loss newly identified by the commission on dementia prevention, intervention and care. If these 14 risk factors are eliminated, nearly half of dementias could theoretically be prevented, Livingston and colleagues wrote. Based on their findings, the researchers outlined 13 recommendations for individuals and governments to prevent dementia: ensure children have access to good-quality education and encourage individuals in midlife to participate in cognitively stimulating activities; reduce harmful noise exposure and make hearing aids accessible to those with hearing impairment; treat depression; promote helmets and other head protection during contact sports and when riding bicycles; encourage exercise; reduce smoking through education and by implementing policies that aim to control the cost of cigarettes; prevent or reduce high blood pressure; diagnose and treat high LDL; maintain a healthy weight and treat obesity early; reduce excessive alcohol use through price control and raising awareness about the risks of overconsumption; reduce social isolation by encouraging activities and living with other people, prioritizing an age-friendly and supportive community, environments and housing; ensure access to vision loss screening and treatment; and decrease air pollution exposure. Although addressing risk factors at an early stage of life is desirable, there is also benefit from tackling risk throughout life; it is never too early or too late to reduce dementia risk, Livingston and colleagues wrote.

• #164 Dementia – reducing your risk | Better Health Channel

  https://www.betterhealth.vic.gov.au/health/conditionsandtreatments/dementia-reducing-your-risk

  Dementia cannot be prevented or cured. […] Healthy brain lifestyle choices throughout your life (but especially at midlife) may help to reduce your risk of dementia. […] Staying physically and mentally active, eating well and avoiding smoking, excessive alcohol and head injury may all protect you from dementia later in life. […] Research shows that those who adopt a brain healthy lifestyle have a reduced risk of dementia in later life. […] Living a brain healthy lifestyle is particularly important once you reach middle age, as this is when changes in the brain start to occur. […] Its never too late or too early to live a brain-healthy lifestyle, as brain function can be improved at any age. […] Understanding the risk factors for developing dementia can help you to make decisions about potential strategies for risk reduction.

• #165 Alzheimer’s Association International Conference

  https://www.healio.com/news/psychiatry/20240731/eliminating-14-risk-factors-may-prevent-nearly-half-of-dementia-cases

  Eliminating these 14 risk factors may prevent nearly half of dementia cases. Tackling 14 risk factors for dementia beginning in childhood could prevent or delay nearly half of cases worldwide, according to a report from the Lancet Commission presented at the Alzheimer’s Association International Conference. These include two risk factors high cholesterol and vision loss newly identified by the commission on dementia prevention, intervention and care. If these 14 risk factors are eliminated, nearly half of dementias could theoretically be prevented, Livingston and colleagues wrote. Based on their findings, the researchers outlined 13 recommendations for individuals and governments to prevent dementia: ensure children have access to good-quality education and encourage individuals in midlife to participate in cognitively stimulating activities; reduce harmful noise exposure and make hearing aids accessible to those with hearing impairment; treat depression; promote helmets and other head protection during contact sports and when riding bicycles; encourage exercise; reduce smoking through education and by implementing policies that aim to control the cost of cigarettes; prevent or reduce high blood pressure; diagnose and treat high LDL; maintain a healthy weight and treat obesity early; reduce excessive alcohol use through price control and raising awareness about the risks of overconsumption; reduce social isolation by encouraging activities and living with other people, prioritizing an age-friendly and supportive community, environments and housing; ensure access to vision loss screening and treatment; and decrease air pollution exposure. Although addressing risk factors at an early stage of life is desirable, there is also benefit from tackling risk throughout life; it is never too early or too late to reduce dementia risk, Livingston and colleagues wrote.

• #166 Dementia – reducing your risk | Better Health Channel

  https://www.betterhealth.vic.gov.au/health/conditionsandtreatments/dementia-reducing-your-risk

  Although there are no guarantees that keeping your heart healthy will prevent dementia, you will give yourself the best chance of avoiding or delaying dementia. […] To reduce your risk of dementia, you should have regular check-ups with your doctor, especially at midlife, and always follow the advice of your doctor. […] Head injury, particularly severe injury (causing unconsciousness for an extended period of time) is a risk factor for the development of Alzheimers disease.

• #167 Can dementia be prevented – NHS

  https://www.nhs.uk/conditions/dementia/about-dementia/prevention/

  There’s no certain way to prevent all types of dementia, as researchers are still investigating how the condition develops. […] However, there’s good evidence that a healthy lifestyle can help reduce your risk of developing dementia when you’re older. […] The research concluded that by modifying the risk factors we are able to change, around 4 in 10 cases of dementia could be prevented. […] Experts agree that what’s good for your heart is also good for your brain. This means you can help reduce your risk of dementia by: eating a balanced diet, maintaining a healthy weight, exercising regularly, keeping alcohol within recommended limits, stopping smoking, keeping your blood pressure at a healthy level. […] If you are overweight or living with obesity, even losing 5% to 10% of the excess weight can help reduce your risk of dementia.

• #168 Reducing your risk of dementia – Alzheimer’s Research UK

  https://www.alzheimersresearchuk.org/dementia-information/reducing-your-risk/

  Just as we can protect other areas of our health, we can take steps to keep our brains healthy and reduce our risk of developing dementia later in life. […] Almost half (45%) of dementia cases worldwide could be prevented or delayed. These cases are linked to factors that affect our health throughout our life. […] Some people may find adopting some of the suggestions on this page easier than others. But even making a couple of changes can go a long way to improve your health, and it’s likely you’ll be reducing your dementia risk too. […] What’s good for your heart is good for your brain. That’s because the brain relies on a good blood supply to stay healthy. Taking steps to look after our heart can help lower our risk of cardiovascular diseases, and our risk of dementia too. […] Getting tested for, and managing, certain long-term health conditions can reduce the damage they cause to our brains over time. In turn, this can reduce our risk of dementia.

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