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• #1 Celiac disease – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/celiac-disease/diagnosis-treatment/drc-20352225

  A strict, lifelong gluten-free diet is the only way to manage celiac disease. […] A dietitian who works with people with celiac disease can help you plan a healthy gluten-free diet. Even trace amounts of gluten in your diet can be damaging, even if they don’t cause symptoms. […] Removing gluten from your diet will typically reduce inflammation in your small intestine, causing you to feel better and eventually heal. Children tend to heal more quickly than adults. […] If your anemia or nutritional deficiencies are severe, supplements may be recommended, including: Copper, Folic acid, Iron, Vitamin B-12, Vitamin D, Vitamin K, Zinc. […] Medical follow-up at regular intervals can ensure that your symptoms have responded to a gluten-free diet. Your health care team may monitor your response with blood tests. Nutritional markers also are checked regularly.

• #2 Treatment & Follow-Up | Celiac Disease FoundationBack to HomeBack to HomeAbout the DiseaseGluten-Free ResourcesResearch ResourcesAdvocacy and Public PolicyJoin the EffortSupport the FoundationShare on FacebookShare on TwitterEmail this pageprinter-miniarr

  https://celiac.org/about-celiac-disease/treatment-and-follow-up/

  Lifelong Adherence to the Gluten-Free Diet The only treatment for celiac disease is to follow a strict gluten-free diet for life. This means avoiding foods and beverages that gluten, a protein found in wheat, rye, barley, and triticale (a hybrid of wheat and rye). […] Vitamins and Dietary Supplements Commonly, people with celiac disease are deficient in fiber, iron, calcium, magnesium, zinc, folate, niacin, riboflavin, vitamin B12, and vitamin D, as well as in calories and protein. […] Medication Medication is not normally required except in some cases of dermatitis herpetiformis, in which medication such as dapsone or sulfapyridine is administered for a short period of time to control the rash. In most individuals, following a strict gluten-free diet greatly reduces symptoms of dermatitis herpetiformis.

• #3 Treatment for Celiac Disease – NIDDK

  https://www.niddk.nih.gov/health-information/digestive-diseases/celiac-disease/treatment

  Doctors treat celiac disease by helping people to follow a gluten-free diet. Symptoms greatly improve for most people with celiac disease who stick to a gluten-free diet. For most people, following a gluten-free diet will heal damage in the small intestine and prevent more damage. Your doctor will explain the gluten-free diet and may refer you to a registered dietitian who specializes in treating people who have celiac disease. A gluten-free diet will treat or prevent many of the symptoms and complications of celiac disease. In untreated celiac disease, damage to the small intestine can lead to malabsorption and malnutrition. When you are diagnosed with celiac disease, your doctor may test you for low levels of certain vitamins and minerals and may recommend or prescribe supplements if you need them. If you continue to have celiac disease symptoms while you are following a gluten-free diet, talk with your doctor or a registered dietitian, who can help you find the cause. Refractory celiac disease is a rare condition in which symptoms and damage to the small intestine continue or come back, even while a person is following a strict gluten-free diet. Doctors may recommend additional testing and treatments to diagnose and manage refractory celiac disease.

• #3

  https://www.nhs.uk/conditions/coeliac-disease/treatment/

  Coeliac disease is treated by excluding foods that contain gluten from your diet. […] If you have coeliac disease, you must stop eating all sources of gluten for life. Your symptoms will return if you eat foods containing gluten, and it will cause long-term damage to your health. […] A GP will offer you an annual review during which your height and weight will be measured and your symptoms reviewed. They’ll also ask you about your diet and assess whether you need any further help or specialist nutritional advice. […] When you’re first diagnosed with coeliac disease, you’ll be referred to a dietitian to help you adjust to your new diet without gluten. […] Gluten is not essential in your diet and it can be replaced by other foods. […] Many foods, such as meat, vegetables, cheese, potatoes and rice, are naturally free from gluten so you can still include them in your diet. A dietitian can help you identify which foods are safe to eat and which are not.

• #4 Celiac Disease: Symptoms & How It’s Treated

  https://my.clevelandclinic.org/health/diseases/14240-celiac-disease

  Most people find their symptoms begin to improve almost immediately after starting a gluten-free diet. It may take several weeks to replace your nutritional deficiencies and several months for your gut to fully heal. It can take longer in some cases, depending on the extent of the damage and how long its been going on. You can also delay healing if you arent strict with your diet.

• #5 Celiac Disease Treatment – Medications, Self-Care, Therapies, Prevention, Specialists

  https://www.webmd.com/digestive-disorders/celiac-disease/celiac-disease-treatment

  There is no medication that treats celiac disease. To avoid the health problems that it can cause, you’ll need to go completely gluten-free. […] The only way to manage the symptoms of celiac disease is to eat a strict gluten-free diet. Eating foods without gluten lets your small intestine heal, and stops future problems and inflammation. […] Sometimes people with celiac disease can be deficient in certain nutrients because their body doesn’t absorb them properly. […] Once you start a gluten-free diet, your intestines should recover and you should be able to absorb these nutrients again. But talk to your doctor to see if you need to take a gluten-free multivitamin or supplement. […] Once you start to follow a gluten-free diet, your symptoms should improve within a few weeks. Many people start to feel better in just a few days. […] Children with celiac disease respond to a gluten-free diet dramatically. Not only do symptoms like diarrhea and abdominal pain go away, but any behavioral issues may also improve. Children also usually return to normal growth rates and quickly catch up in height.

• #6 Celiac Disease: Symptoms, Treatment, and More

  https://www.healthline.com/health/celiac-disease-sprue

  Celiac disease is a digestive disorder caused by an abnormal reaction to gluten. […] People with celiac disease need to eliminate all forms of gluten from their diet. This allows your intestinal villi to heal and begin absorbing nutrients properly. […] A doctor or a registered dietitian can teach you how to avoid gluten and how to follow a nutritious gluten-free diet. […] Symptoms can improve within days of removing gluten from your diet. […] The only way to treat celiac disease is to permanently remove gluten from your diet. […] You can talk with a healthcare professional about taking a supplement, such as a multivitamin or an iron supplement. […] Gluten-digesting enzymes are another supplement on the market that may be helpful for non-celiac gluten sensitivity. […] Again, before starting an enzyme or any other supplement, you should schedule an appointment with a healthcare professional to discuss the potential benefits and risks. […] Your symptoms should improve within days to weeks of cutting all gluten out of your diet. In children, the intestine usually heals in 3 to 6 months. Intestinal healing may take several years in adults. Once your intestine completely heals, your body will be able to properly absorb nutrients.

• #7 Celiac Disease Treatment | BeyondCeliac.org

  https://www.beyondceliac.org/celiac-disease/treatment/

  There is no cure for celiac disease, which is a life-long autoimmune condition. However, there is a treatment that can relieve symptoms: eating gluten-free. […] Every patient diagnosed with celiac disease will be instructed to eat gluten-free for the rest of their life. Some may also be prescribed nutritional supplements, and patients with dermatitis herpetiformis, a skin rash associated with celiac disease, may be prescribed dapsone or another drug to relieve itching. Patients with refractory celiac disease, a rare and aggressive form of the condition, may be put on immunosuppressants to calm the immune system. […] Currently, the only treatment for celiac disease is a lifelong gluten-free diet. Even small amounts of gluten can damage the intestine in those with celiac disease, so people with celiac disease don’t have “cheat days.”

• #8 Treatment & Follow-Up | Celiac Disease FoundationBack to HomeBack to HomeAbout the DiseaseGluten-Free ResourcesResearch ResourcesAdvocacy and Public PolicyJoin the EffortSupport the FoundationShare on FacebookShare on TwitterEmail this pageprinter-miniarr

  https://celiac.org/about-celiac-disease/treatment-and-follow-up/

  Physician Follow-Up At Time of Diagnosis At time of diagnosis, your physician should: Recommend a dietitian expert in celiac disease and the gluten-free diet to provide education and counseling. […] Dietitian Follow-Up At Time of Diagnosis At time of diagnosis, your dietitian should: Provide gluten-free dietary counseling, including education on the inclusion of oats, cross-contamination, and label-reading for foods, medications and supplements.

• #9 Celiac Disease: Symptoms & How It’s Treated

  https://my.clevelandclinic.org/health/diseases/14240-celiac-disease

  Celiac disease Treatment Find a Doctor and Specialists Make an Appointment […] The first and most important step in treating celiac disease is to stop eating gluten. You cant change the way your body reacts to gluten, but you can prevent gluten from triggering that reaction. When you stop eating gluten, your small intestine will begin to heal and will soon be able to absorb nutrients again. You have to maintain a strict gluten-free diet for life, though, to avoid hurting your small intestine again. […] Additional treatment may include: Nutritional supplements to replace any serious deficiencies. Specific medications to treat dermatitis herpetiformis, such as dapsone. Corticosteroids for severe inflammation thats not responding fast enough to the diet. Continuous follow-up care, including regular testing to make sure the disease is controlled.

• #10

  https://www.nhs.uk/conditions/coeliac-disease/treatment/

  As well as eliminating foods that contain gluten from your diet, there are other treatments available for coeliac disease. […] A GP or dietitian may also recommend taking vitamin and mineral supplements if you need them, for example for iron deficiency anaemia. […] If you have dermatitis herpetiformis (an itchy rash that can be caused by gluten intolerance), cutting gluten out of your diet should help. […] If refractory coeliac disease is suspected, it’s likely you’ll be referred for a series of tests to make sure your symptoms are not being caused by another condition. […] Treatment options include steroid medicine, such as prednisolone, or immunosuppressant medicine, which help block the harmful effects of the immune system.

• #11

  https://www2.hse.ie/conditions/coeliac-disease/treatment/

  By law, food labelled as gluten-free cannot contain more than 20mg/kg of gluten. […] Other treatments include vaccinations, supplements, and medication to treat rashes. […] Your GP or dietitian may recommend vitamin and mineral supplements. This may be for the first 6 months after diagnosis. This helps you to get all the nutrients you need while your digestive system repairs. Supplements also help correct a lack of iron in the blood. […] Cutting out gluten should clear it up. […] If refractory coeliac disease is suspected, it’s likely you’ll be referred for tests. This is to make sure your symptoms aren’t caused by another condition. […] If the diagnosis is confirmed, you’ll get a referral to a specialist. Treatment options include steroid medication. These help block the harmful effects of the immune system.

• #12 Celiac Disease Treatment | BeyondCeliac.org

  https://www.beyondceliac.org/celiac-disease/treatment/

  While a gluten-free diet is the cornerstone of managing celiac disease, some treatments target the symptoms of this condition. […] Many patients with celiac disease have damaged intestines. The intestines will heal over time, but if your doctor is concerned about nutritional intake after your diagnosis, they may prescribe supplements or injections. […] Dermatitis herpetiformis (DH) is an extremely itchy skin rash associated with celiac disease. The most common medication used to treat it is dapsone. […] For patients with refractory celiac disease, the immune system attacks the intestines even on a gluten-free diet. Immunosuppressants can help. […] Every day, scientists from across the globe work to develop new treatments for celiac disease beyond the gluten-free diet. […] Although researchers are working on additional treatments, there are currently no treatments that allow people with celiac disease to eat foods containing gluten. There are also no proven home remedies or homeopathic treatments for celiac disease. The only treatment that has demonstrated effectiveness is following a completely gluten-free diet (with immunosuppressants on rare occasions).

• #13 Celiac disease – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/celiac-disease/diagnosis-treatment/drc-20352225

  For most people with celiac disease, eating a gluten-free diet allows the small intestine to heal. […] If your small intestine is severely damaged or you have refractory celiac disease, steroids may be recommended to control inflammation. […] If you have this skin rash, a medicine called dapsone may be recommended in addition to a gluten-free diet. […] With refractory celiac disease, the small intestine doesn’t heal. Refractory celiac disease can be quite serious, and there is currently no proven treatment.

• #14 Clinical Practice Update: How to manage refractory celiac disease – American Gastroenterological AssociationAGA Logo_Horizontal

  https://gastro.org/news/clinical-practice-update-how-to-manage-refractory-celiac-disease/

  Corticosteroids, most commonly open-capsule budesonide or, if unavailable, prednisone, are the medication of choice and should be used as first-line therapy in either type 1 or type 2 refractory celiac disease. […] Patients with refractory celiac disease require regular follow-up by a multidisciplinary team, including gastroenterologists and dietitians, to assess clinical and histologic response to therapy. […] Patients with refractory celiac disease without response to steroids may benefit from referral to a center with expertise for management or evaluation for inclusion in clinical trials.

• #15 Treatment for Refractory Celiac Disease

  https://www.verywellhealth.com/refractory-celiac-disease-treatment-562630

  So your healthcare provider may start your treatment by checking your body’s level of vitamins, minerals, and other nutrients, and prescribing nutritional support to help reverse your malnutrition. […] In a few cases involving Type I disease, nutritional support and a very strict gluten-free diet may be all you need to begin healing. But most people also receive drug treatment. […] To date, drug treatment of refractory celiac disease has focused on therapies designed to suppress your immune system in an effort to give your intestines a break from the relentless autoimmune attack. […] In both Type I and Type II refractory celiac disease, the first-line drug treatment is typically a form of steroid medication known as glucocorticoids. […] Research shows that most people with Type I refractory celiac disease will go into remission, in other words, see their symptoms resolve and their intestines begin to heal through the use of steroids, possibly combined with azathioprine.

• #15 Treatment for Refractory Celiac Disease

  https://www.verywellhealth.com/refractory-celiac-disease-treatment-562630

  Refractory celiac disease can be a frightening diagnosis. By definition, it means the standard treatment for celiac disease, the gluten-free diet, has failed to work, and you must now seek alternatives. […] However, if your healthcare provider rules out other causes and you ultimately are diagnosed with refractory celiac disease, you should know that healthcare provider are able to treat the majority of cases successfully; treatment will depend on what type of refractory celiac you suffer from, along with other factors in your medical history and condition. […] Under most circumstances, you will be treated for refractory celiac disease at a celiac center with experience handling and monitoring the condition; because refractory celiac is so rare, many gastroenterologists haven’t handled cases before.

• #16 Old and New Adjunctive Therapies in Celiac Disease and Refractory Celiac Disease: A Review

  https://www.mdpi.com/1422-0067/24/16/12800

  Thus, outdated drugs often already used for other diseases are our best therapeutic tools in this setting. […] The aim of this review is to analyse and discuss the available adjunctive therapies for the treatment of CD and RCD, as well as to present the novel therapies that are emerging in the current literature for the treatment of RCD and the possibilities to consider using them in future clinical practice. […] The standard of care in the management of patients with celiac disease is the GFD; however, clinical, biochemical, and histological recovery are often delayed and could take several months or even years to achieve complete mucosal healing. […] In conclusion, the high-quality RCTs and the overall body of evidence showed little to no effect of the steroids compared to GFD on the improved histological outcome or clinical symptoms regression.

• #17 Celiac Disease (Sprue) Treatment & Management: Approach Considerations, Medical Care, Probiotics

  https://emedicine.medscape.com/article/171805-treatment

  A small percentage of patients with celiac disease fail to respond to a gluten-free diet. In some patients who are refractory, corticosteroids might be helpful. […] Through targeted probiotic use, many clinical trials have investigated the restoration of the balance of the microbiota composition. […] The use of probiotics has also been proposed in multiple pilot randomized controlled trials on children with only a small sample size. […] Nonresponsive celiac disease is commonly encountered in clinical practice, occurring in most cases due to nonadherence to a gluten-free diet. However, refractory celiac disease is rare; it is caused by gluten-independent autoimmunity (type I) or low grade lymphoma in the epithelium (type II). […] Monitor CD patients regularly for persistent or new symptoms, adherence to a GFD, and assessment for complications.

• #18 Celiac Disease | Symptoms, Diagnosis & Treatment

  https://www.cincinnatichildrens.org/health/c/celiac-disease

  When a person with celiac disease eats gluten, their immune system attacks the small intestine. […] Right now, there is no cure for celiac disease. Following a strict, 100% gluten-free diet is the only way to treat it. […] There is no cure for celiac disease. People with this lifelong condition must remove gluten from their diet to have the best health and quality of life possible. […] Children with celiac disease need to follow up with their care team every six to 12 months. This is a chance for the doctor to monitor the child’s progress, ask about symptoms and see how the gluten-free diet is going. Blood tests can help the doctor see if the immune system is still active against gluten. They also show if the small intestine is healing. […] A dietitian can help you as you make changes to your child’s eating habits on the road toward better health. The dietitian can help you: Understand what a gluten-free diet is. Learn how to read food labels to avoid gluten. Find hidden sources of gluten. Ensure your child still gets the nutrition needed for growth and development. Find gluten-free substitutes for your child’s favorite foods.

• #19 Future Therapies | Celiac Disease FoundationBack to HomeBack to HomeAbout the DiseaseGluten-Free ResourcesResearch ResourcesAdvocacy and Public PolicyJoin the EffortSupport the FoundationShare on FacebookShare on TwitterEmail this pageprinter-miniRelated

  https://celiac.org/about-celiac-disease/future-therapies-for-celiac-disease/

  Currently, the only available treatment for a patient with celiac disease is a strict gluten-free diet. A lifelong diet completely free of gluten can be very costly and challenging. Many patients’ intestines don’t heal completely, and they continue to suffer from symptoms, most often due to imperfect adherence to the gluten-free diet. […] Future drug therapies are currently in development with the hope of reducing the burden of living with celiac disease and improving long-term health outcomes. […] Allero is currently developing their lead product for the treatment of celiac disease. […] AMYRA is a biotech company that is developing a novel enzyme-based treatment for celiac disease. […] AnTolRx is a biotechnology company focused on revolutionizing the treatment of autoimmune diseases, including celiac disease.

• #19 Future Therapies | Celiac Disease FoundationBack to HomeBack to HomeAbout the DiseaseGluten-Free ResourcesResearch ResourcesAdvocacy and Public PolicyJoin the EffortSupport the FoundationShare on FacebookShare on TwitterEmail this pageprinter-miniRelated

  https://celiac.org/about-celiac-disease/future-therapies-for-celiac-disease/

  KAN-101 acts by re-educating T cells, or tolerizing them, so they do not respond to gluten antigens. […] Entero is developing latiglutenase (also known as IMGX003), a mixture of two gluten-specific enzymes that break down gluten proteins into small, harmless fragments. […] Investigators at Oslo University Hospital are currently testing the effects of teriflunomide on patients with celiac disease. […] Investigators at the Massachusetts General Hospital are conducting a double-blind, placebo-controlled trial to establish the safety and efficacy of Ritlecitinib to prevent gluten-induced symptoms in celiac disease patients. […] A phase 2b clinical trial was completed in 2024. […] Investigators are conducting a Phase 2a/b study to evaluate the efficacy and safety of Amlitelimab in adult participants with non-responsive celiac disease who are on a gluten-free diet.

• #19 Future Therapies | Celiac Disease FoundationBack to HomeBack to HomeAbout the DiseaseGluten-Free ResourcesResearch ResourcesAdvocacy and Public PolicyJoin the EffortSupport the FoundationShare on FacebookShare on TwitterEmail this pageprinter-miniRelated

  https://celiac.org/about-celiac-disease/future-therapies-for-celiac-disease/

  Takeda is currently conducting a phase 2 dose-ranging study to evaluate the efficacy and safety of TAK-062 for the treatment of active celiac disease in individuals attempting a gluten-free diet. […] Takeda is conducting a phase 2 dose-ranging study to further explore the potential of TAK-101 in the treatment of patients with celiac disease on a gluten-free diet. […] A phase 2a proof-of-concept gluten-challenge study revealed that TAK-227 successfully reduced gluten-induced duodenal mucosal damage in people with celiac disease. […] Teva is now conducting a phase 2a trial assessing whether the study drug reduces intestinal damage and inflammation attributed to celiac disease after gluten consumption.

• #19 Future Therapies | Celiac Disease FoundationBack to HomeBack to HomeAbout the DiseaseGluten-Free ResourcesResearch ResourcesAdvocacy and Public PolicyJoin the EffortSupport the FoundationShare on FacebookShare on TwitterEmail this pageprinter-miniRelated

  https://celiac.org/about-celiac-disease/future-therapies-for-celiac-disease/

  Enteralia is developing E40, an oral enzyme that effectively breaks down gluten even in the absence of pepsin. […] IGY Life Sciences is researching the effectiveness of an oral therapeutic using a capsule-based format to deliver the antibodies directly to the small intestine where the inflammation takes place for better management of celiac disease. […] IM Therapeutics’ approach to celiac disease is to identify and develop an oral small-molecule drug that blocks the function of HLA-DQ2, the major genetic risk factor for celiac disease. […] Imcyse is applying its Imotope™ technology for the treatment of various chronic autoimmune diseases, including celiac disease. […] Parvus is developing a pipeline of novel Navacim™ candidates, which create disease-specific immune suppression while avoiding general immune suppression.

• #19 Future Therapies | Celiac Disease FoundationBack to HomeBack to HomeAbout the DiseaseGluten-Free ResourcesResearch ResourcesAdvocacy and Public PolicyJoin the EffortSupport the FoundationShare on FacebookShare on TwitterEmail this pageprinter-miniRelated

  https://celiac.org/about-celiac-disease/future-therapies-for-celiac-disease/

  Provid focuses on synthetic and medicinal chemistry and is developing inhibitors of DQ2 and DQ8, the two genes associated with celiac disease. […] Barinthus Bio is developing VTP-1000 for the treatment of celiac disease. […] Chugai is developing an investigational medication designed to target an immune complex known to cause celiac disease symptoms. […] Forte initiated patient-based studies in celiac disease in the third quarter of 2024. […] Immunic is currently preparing for further clinical testing of IMU-856. […] Mozart Therapeutics is currently conducting a phase 1a/b clinical trial of MTX-101. […] The goal of this phase 1b study was to learn whether PTG-100 can reduce or prevent inflammatory injury to the small intestine that occurs when people with celiac disease eat food products containing gluten.

• #20 Current and emerging therapies for coeliac disease | Nature Reviews Gastroenterology & Hepatology

  https://www.nature.com/articles/s41575-020-00378-1

  Coeliac disease is a common enteropathy that occurs in genetically susceptible individuals in response to the ingestion of gluten proteins present in wheat, rye and barley. Currently, the only available treatment for the condition is a strict, life-long gluten-free diet that, despite being safe and often effective, is associated with several challenges. […] At present, a gluten-free diet is the only effective treatment for coeliac disease but is associated with several possible challenges, including a high economic and societal burden, inferior quality of life and sometimes inadequate response. […] An increased understanding of the pathogenetic process in coeliac disease has revealed various therapeutic targets for future drugs that could complement or replace a gluten-free diet. […] Novel therapeutic strategies include approaches to detoxify gluten already in the gastrointestinal tract by sequestrants or peptidases.

• #20 Current and emerging therapies for coeliac disease | Nature Reviews Gastroenterology & Hepatology

  https://www.nature.com/articles/s41575-020-00378-1

  Other investigational approaches comprise blocking intestinal epithelial permeability or the enzymatic activity of transglutaminase 2. […] Restoring immune tolerance to gluten or targeting the gluten-induced immune activation has also been investigated as possible therapeutic options. […] The most advanced drug candidates have now entered phase III clinical trials.

• #21 Drugs for Celiac Disease May Be on the Horizon | Columbia University Irving Medical Center

  https://www.cuimc.columbia.edu/news/drugs-celiac-disease-may-be-horizon

  The only safe and effective treatment for celiac disease is to avoid food and drinks that contain gluten, a protein found naturally in wheat, barley, and rye. […] For these reasons, many companies and researchers are looking for drugs to treat celiac disease in addition toor instead ofthe gluten-free diet. […] In the past decade, the landscape of drug therapy for celiac disease has evolved from a mere concept to more than a dozen candidate medications in trials with patients. […] Some of the candidates work by preventing the consequences of accidental gluten exposure. […] For example, latiglutenase is taken with meals and contains enzymes that break down gluten in the stomach, rendering the protein non-toxic to patients with celiac disease. […] A second category of drugs attempts to re-educate the patients immune system so it no longer reacts to gluten.

• #21 Drugs for Celiac Disease May Be on the Horizon | Columbia University Irving Medical Center

  https://www.cuimc.columbia.edu/news/drugs-celiac-disease-may-be-horizon

  If found to be effective, this category of medication may allow people with celiac disease to eat gluten without harmful consequences. […] Columbias Celiac Disease Center has an active clinical research program that is recruiting volunteers to participate in several trials for these potential treatments. […] Our goal is to have a diversity of trials so that we can be at the forefront of the most promising therapies for celiac disease. […] Lebwohl feels optimistic that clinical trials could lead to the approval of at least one of these candidate drugs within the next decade. […] The number of drugs in development and the variety of mechanisms make it likely that one of these approaches will allow for a safe and effective non-dietary therapy to emerge, he says.

• #22 New Treatments for Celiac Disease Gain Traction – BioSpace

  https://www.biospace.com/drug-development/opinion-new-treatments-for-celiac-disease-gain-traction

  There are currently no treatments available for celiac disease beyond a gluten-free diet. […] Several companies are working on late-stage investigational treatments to treat celiac disease via a variety of therapeutic approaches. If ultimately approved, these treatments should change care for the disease profoundly by removing the burdensome need for total gluten avoidance. […] The frontrunner, Entero Therapeutics, is researching latiglutenase, an enzyme that breaks down gluten in the stomach. […] In May 2024, Anokion reported results from the Phase Ib/II ACeD-it trials, revealing that KAN-101 was safe and remained well-tolerated at higher dose levels up to 3 mg/kg. In addition, functional tolerance to gluten was observed. […] Elsewhere, Sanofi is enrolling Phase II trials of amlitelimab, an OX40L subcutaneous monoclonal antibody. […] Finally, Takeda is developing three investigational agents to treat celiac disease. […] In conclusion, several investigational treatments are vying to treat celiac disease.

• #23 New and Developing Therapies for Celiac Disease

  https://pmc.ncbi.nlm.nih.gov/articles/PMC3002532/

  Another therapeutic target is to prevent the migration of luminal gluten peptides across the intestinal epithelium. […] While therapies currently being investigated aim to decrease the amount of gluten reaching the small bowel or its migration across the intestinal epithelium, another potential target of drug therapy is modulation of the immune response to gluten. […] Therapies to decrease gluten exposure, to modify intestinal permeability and to modulate immune activation, represent exciting emerging treatments for celiac disease, but a gluten-free diet is virtually without side effects. […] The gluten-free diet still represents the best and safest treatment for celiac patients. […] Any new potential treatment must have a similar safety profile to the gluten-free diet.

• #24 New Approaches to Treating Celiac Disease – Premier Medical Group

  https://www.premiermedicalhv.com/news/new-approaches-treating-celiac-disease/

  For the last thirty years, the best we could do for our patients with celiac disease was advise them to go on a gluten-free diet. […] Finally, several treatments being developed hold forth the prospect of better management of celiac disease and an enhanced quality of life for those who have it. […] Studies show that it is possible to breed gluten proteins that do not stimulate an autoimmune response. […] Another promising approach involves developing a therapeutic vaccine for celiac disease, Khurana says. […] The vaccine will be given in multiple small doses, by injection, creating immune tolerance and preventing the damaging inflammation of CD. […] One of the treatments closest to becoming available, perhaps within the next five years, is a zonulin inhibitor. […] The zonulin inhibitors will interrupt the process and keep the gluten from getting into the cells and damaging the villi, Khurana says.

• #25 New treatment may reverse celiac disease – Northwestern Now

  https://news.northwestern.edu/stories/2019/10/new-treatment-may-reverse-celiac-disease/

  Results of a new phase 2 clinical trial using technology developed at Northwestern Medicine show it is possible to induce immune tolerance to gluten in individuals with celiac disease. The findings may pave the way for treated celiac patients to eventually tolerate gluten in their diet. […] After treatment with the technology, the patients were able to eat gluten with a substantial reduction in inflammation. […] In the celiac disease trial, the nanoparticle was loaded with gliadin, the major component of dietary gluten, found in cereal grains such as wheat. A week after treatment, the patients were fed gluten for 14 days. Without treatment, celiac patients eating gluten developed marked immune responses to gliadin and damage in their small intestine. Celiac patients treated with the COUR nanoparticle, CNP-101, showed 90% less immune inflammation response than untreated patients. By stopping the inflammatory response, CNP-101 showed the capacity to protect the intestines from gluten related injury.

• #26 Barinthus Bio Initiates Phase 1 Clinical Trial of VTP-1000

  https://www.globenewswire.com/news-release/2024/09/24/2952091/0/en/Barinthus-Bio-Initiates-Phase-1-Clinical-Trial-of-VTP-1000-for-the-Treatment-of-Celiac-Disease.html

  VTP-1000 is an investigational, injectable antigen-specific tolerance immunotherapy that utilizes Barinthus Bios proprietary SNAP-TI platform to co-deliver multiple gluten-derived peptide antigens (from wheat, barley and rye proteins) and the immunomodulator rapamycin in nanoparticles to promote immune tolerance to gluten.

• #27 New Hope for Celiac Disease: Promising Drug Shows Progress in Clinical Trials | Celiac Disease FoundationBack to HomeBack to HomeAbout the DiseaseGluten-Free ResourcesResearch ResourcesAdvocacy and Public PolicyJoin the EffortSupport the Foundation

  https://celiac.org/2024/07/24/maki-trial-2024/

  New research from Tampere University in Finland shows exciting progress in a new drug for celiac disease. This drug, ZED1227 could be used alongside a gluten-free diet to help manage celiac disease. […] The drug ZED1227 could help by blocking TG2, preventing the harmful changes to gluten and reducing intestinal damage. […] The results showed that ZED1227 successfully blocked the harmful immune reactions caused by gluten, preventing damage and inflammation in the intestines. […] ZED1227 represents a promising adjunct therapy to the gluten-free diet, potentially protecting against intestinal damage even in patients with low levels of gluten exposure. […] Research and further development are still out there. The message for patients is that first line therapies will potentially be adjunct to a gluten-free diet, meant to those with symptoms respite their gluten-free diet and or to those where inadvertent gluten ingestion causes small intestinal mucosal lining injury.

• #28 New study demonstrates the efficacy of a promising celiac disease drug at the molecular level

  https://medicalxpress.com/news/2024-06-efficacy-celiac-disease-drug-molecular.html

  A recent study led by researchers at Tampere University investigated whether a transglutaminase 2 inhibitor has potential as a drug to treat celiac disease. Previous tissue studies have shown that the ZED1227 transglutaminase 2 inhibitor prevents gluten-induced intestinal damage. […] The results of the new study, based on an analysis of the molecular activity of more than 10,000 genes, provide very strong evidence that the first successful drug to treat celiac disease may be at hand. […] Currently, no drug therapy exists, and a life-long strict gluten-free diet is the only available treatment. However, symptoms and intestinal damage caused by hidden gluten can occur even in patients who are following a strict diet. […] In a previous tissue study coordinated by Professor Emeritus Markku Mäki from Tampere University, the ZED1227 transglutaminase 2 inhibitor was shown to prevent gluten-induced intestinal damage in patients with celiac disease. However, its mechanisms of action are not fully understood yet.

• #29 What’s New in Celiac Disease News? Chugai Pharmaceutical Publishes Non-Clinical Research Results on DONQ52 for Celiac Disease | Celiac Disease FoundationBack to HomeBack to HomeAbout the DiseaseGluten-Free ResourcesResearch ResourcesAdvocacy and Public Po

  https://celiac.org/2024/01/18/whats-new-in-celiac-disease-news-chugai-pharmaceutical-publishes-non-clinical-research-results-on-donq52-for-celiac-disease/

  Chugai Pharmaceutical Co., Ltd., a Japanese pharmaceutical company, recently published encouraging results from a non-clinical study on DONQ52, an experimental medication for celiac disease. The findings show the potential for DONQ52 to block the immune response to gluten in celiac disease without affecting the rest of the immune system. […] If successful, this medication could represent a significant breakthrough in the treatment of celiac disease. […] The results support DONQ52 as a promising candidate for further clinical testing in celiac disease. A treatment option that could improve or replace a lifelong gluten-free diet would significantly benefit people with celiac disease. […] New experimental treatment options, such as DONQ52, hold promise for bettering the lives of those with celiac disease in the future.

• #30

  https://penntoday.upenn.edu/news/penn-medicine-pursuing-vaccines-stop-celiac-disease

  Currently, theres no treatment for celiac disease aside from avoiding gluten. […] When it comes to treating celiac disease, the need is different. In a way, we want to use mRNA to induce the opposite response youd want for an infectious disease vaccine, says Melamed. For diseases like COVID, you want to induce an infection-fighting response; for celiac disease, we want to stop the immune response already happening in the body. […] The idea is to make what experts call a tolerizing vaccine, or a vaccine that would allow someones body to tolerate the thing its reacting to; in this case, that would be the gluten protein.

• #31 Celiac Disease Psychosocial Services – Stanford Medicine Children’s Health

  https://www.stanfordchildrens.org/en/services/celiac-disease/psychosocial-services.html

  Celiac disease affects not only your child but also your entire family. […] Our celiac disease team is here to support you and your family as you navigate a celiac disease diagnosis and learn ways to cope with stress related to living gluten free. […] This evaluation leads to individualized treatment recommendations, including techniques for stress and pain management, treatment adherence, school support, supportive counseling with the social worker and psychologist, celiac disease support groups, peer-to-peer support, and/or additional support through individual and family therapy in the community. […] A variety of psychological techniques and interventions are available to help your child and family adjust to celiac disease. […] Treatment modalities include cognitive behavioral therapy, relaxation-based therapies, biofeedback, and mindfulness-based treatments.

• #31 Celiac Disease Psychosocial Services – Stanford Medicine Children’s Health

  https://www.stanfordchildrens.org/en/services/celiac-disease/psychosocial-services.html

  We can provide nonpharmacological (nonmedicine) techniques and behavioral therapies to help your child cope with pain and other bothersome symptoms. […] If your child is struggling with following the gluten-free diet, our psychologist, dietitian, and social worker collaborate with you and our medical providers to support adherence (staying on track with a treatment plan) by using creative and innovative strategies. […] Our celiac disease social worker partners with you to support your child’s academic growth and success.

• #32 Get Celiac Disease Treatment | Cleveland Clinic

  https://my.clevelandclinic.org/services/celiac-disease-treatment

  At Cleveland Clinic, we go beyond getting rid of gluten. We offer whole-person care that helps you improve both physically and emotionally. […] Our experienced dietitians will help you put together a personalized diet plan that meets your nutritional needs and prevents vitamin and mineral deficiencies, like vitamin D. […] While your custom treatment plan sets you up for success, youll still need to see us regularly to check on your small intestine and your overall health. […] Its important to remain gluten-free for life because even a small amount can damage your small intestine and restart all of your problems. […] We know it can be exhausting and stressful to face a chronic issue like celiac disease. Thats why your care team includes mental health professionals who treat depression, anxiety and other conditions.

• #33 Management of celiac disease in adults – UpToDate

  https://www.uptodate.com/contents/management-of-celiac-disease-in-adults

  Celiac disease can be defined as a condition in which there is an abnormal small intestinal mucosa that improves morphologically when treated with a gluten-free diet and relapses when gluten is reintroduced. […] As a general rule, there are six key elements in the management of patients with celiac disease, which can be summarized with the following acronym: Consultation with a skilled dietitian, Education about the disease, Lifelong adherence to a gluten-free diet.

• #34 6 Celiac Disease Therapies to Watch Out

  https://www.delveinsight.com/blog/celiac-disease-therapies-to-watch-out

  The introduction of these new therapies for celiac disease is set to have a major impact on the market by providing alternative treatment options for patients who have traditionally relied on a strict gluten-free diet. […] With improved symptom control and the possibility of modifying the disease, these celiac disease therapies could help prevent long-term complications like osteoporosis, infertility, and an elevated risk of certain cancers. […] As science advances, these innovations, combined with personalized medicine, could significantly improve the quality of life for individuals with celiac disease and potentially offer a cure or more effective management options in the future.

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