Materiały źródłowe

• #1 Can Celiac Disease Be Prevented?

  https://pmc.ncbi.nlm.nih.gov/articles/PMC8160282/

  Celiac disease (CD) is an autoimmune disorder triggered by gluten in genetically susceptible individuals characterized by a variable combination of gluten-dependent symptoms, presence of specific autoantibodies and enteropathy. The health burden of CD is considerable, as it reduces quality of life and, at a societal level, has extensive negative economic consequences. Prevention strategies are based on the identification of at-risk subjects and identification and elimination of risk factors. […] A strategy for primary prevention is based on the identification of at risk subjects primary target of the intervention and on the identification of environmental factors that favor disease development whose manipulation may decrease the risk. […] Early diagnosis through screening policies based on the detection of CD-associated autoantibodies and efforts to assure compliance with the gluten free diet represent the basis for secondary and tertiary prevention of CD. However, this mini-review will mainly focus on primary prevention and on the possible strategies to halt the disease process before mucosal damage occurs.

• #2 Mayo Clinic Q and A: No proven way to prevent celiac disease – Mayo Clinic News Network

  https://newsnetwork.mayoclinic.org/discussion/mayo-clinic-q-and-a-no-proven-way-to-prevent-celiac-disease/

  At this time, there is no proven way to prevent celiac disease. But if your child is considered to be at high risk for the disease due to family or medical history, there may be some steps you can take to lower that risk or to identify the disease early. […] Based on those findings, the current recommendation is for parents of children at high risk for celiac disease to follow the guidelines issued by the American Academy of Pediatrics, or AAP, for food introduction. […] If you have a family history of celiac disease, you could have your child tested to see if she or he has the permissive genotype for celiac disease, known as HLA DQ2/8. If the child doesn’t have it, you don’t need to worry about celiac disease. […] If the child has that genotype, you should still introduce foods, including those that contain gluten, according to the American Academy of Pediatrics guidelines. Then, you could consider having the child screened for celiac disease three to five years after gluten introduction — or sooner if you notice symptoms that could be related to celiac disease.

• #3 Celiac Disease Prevention

  https://pmc.ncbi.nlm.nih.gov/articles/PMC6284033/

  Celiac disease (CD) is a common autoimmune disorder induced by ingestion of gluten in genetically susceptible individuals. […] The incidence of CD has increased over the last half-century, resulting in rising interest in identifying risk factors for CD to enable primary prevention. […] Early infant feeding practices have been suggested as one of the factors influencing the risk of CD in genetically susceptible individuals. However, recent large prospective studies have shown that neither the timing of gluten introduction nor the duration or maintenance of breastfeeding influence the risk of CD. […] Secondary prevention is possible through early diagnosis and treatment. […] As following a gluten-free diet is a major challenge, tertiary prevention strategies are discussed as well. […] The purpose of this review is to present the current knowledge of the preventive strategies for CD.

• #4 Celiac Disease Prevention

  https://pmc.ncbi.nlm.nih.gov/articles/PMC6284033/

  Prevention is defined as any activity that reduces the burden of mortality or morbidity from disease, taking place at the primary, secondary, or tertiary level. […] In accordance with the results from the above-mentioned studies, ESPGHAN has updated its guidelines for gluten introduction into the diet of young children. The current recommendation no longer suggests introducing gluten between 4 and 6 months of age; rather they recommend that gluten may be introduced into the infant’s diet anytime between 4 and 12 completed months of age, since gluten introduction in these infants does not seem to influence the absolute risk of developing CDA or CD during childhood. […] In conclusion, in the field of primary prevention, infant feeding practices have been explored by interventional studies with long-term follow up, but have shown no protection for risk of CD. Other possible influences on the development of CD, especially the role of infections and the gut microbiome, need further research.

• #5 Celiac Disease Prevention

  https://pmc.ncbi.nlm.nih.gov/articles/PMC6284033/

  Secondary prevention focuses on early detection and treatment. […] Screening the general population, also called mass screening, would theoretically be the best form of secondary prevention since it could potentially detect all cases of CD, including those in asymptomatic patients as well as those in patients who lack symptoms. […] However, mass screening for CD is still debated, partly because evidence has been lacking on the accuracy of diagnostic tests and on the health benefits after diagnosis and treatment of asymptomatic detected patients. […] Tertiary prevention focuses on reducing the impact of existing disease by improved treatment. […] One of these strategies involves optimizing adherence to the GFD. […] However, not all of these therapies have been tested in clinical trials (yet). The most advanced studies are devoted to larazotide acetate and prolyl-endopeptidases degrading toxic gluten peptides and to therapeutic vaccination.

• #6 What Causes Celiac Disease, and Can It Be Prevented? – Lompoc Valley Medical Center

  https://www.lompocvmc.com/blogs/2022/august/what-causes-celiac-disease-and-can-it-be-prevent/

  Celiac disease cannot necessarily be prevented, but it can be successfully managed and improved with the right diet and behaviors. […] There are currently no proven ways to prevent celiac disease. According to a 2018 study published in Frontiers in Pediatrics, only a small percentage of people at genetic risk end up getting this disease. […] If you are diagnosed with celiac disease, you may be able to prevent it from causing further damage to your small intestine. This can be achieved by eating a healthy and strict gluten-free diet. Researchers say a gluten-free diet may even reverse damage to the small intestine caused by celiac disease. […] Diagnosing celiac disease often requires changing your diet and lifestyle to avoid gluten. If you need help adjusting to life with celiac disease, ask your doctor about support groups in your area for people with this condition.

• #7 Celiac Disease – familydoctor.org

  https://familydoctor.org/condition/celiac-disease/

  There is no way to prevent or avoid getting celiac disease. […] Celiac disease is serious. Fortunately, you can control the disease by following a gluten-free diet. This means you remove gluten completely from your diet. By doing this, you can reverse the damage caused by celiac disease. You’ll feel better. But if you “cheat” on your diet, the damage will come back. Sometimes you may not feel sick right away, so you think it’s okay to eat gluten. But it’s not.

• #8 Celiac Disease: Symptoms, Testing, Treatment & Research

  https://www.beyondceliac.org/celiac-disease/

  Celiac disease is hereditary, which means that in order to develop it you have to have one or both of the HLA-DQ2 and HLA-DQ8 genes. […] Beyond Celiac is dedicated to supporting research to identify the factors that lead to the development of celiac disease, with the goal of being able to actually prevent the disease from starting.

• #9 Celiac Disease Prevention | SpringerLink

  https://link.springer.com/chapter/10.1007/978-3-030-82401-3_11

  Only a minority of the 40% of the Caucasian population that has a genetic predisposition for celiac disease develops it. […] Environmental and/or lifestyle factors may play a causal role in the development of the disease and their identification may allow its primary prevention. […] Recent studies in birth cohorts suggest that the quantity of gluten consumed early in life, especially if accompanied by viral infections, as well as the type of diet after weaning, may be preventable risk factors for celiac disease development, but randomized controlled intervention trials are needed. […] The role of the gut microbiome is being extensively studied, but at this moment no causal role has been found and the results of prospective studies are expected.

• #10 Can Celiac Disease Be Prevented?

  https://pmc.ncbi.nlm.nih.gov/articles/PMC8160282/

  Breastfeeding has for long time been considered the main protective factor for the development of CD. More recently, the evidence coming from most studies including the two large interventional studies on children at risk for CD, have concluded that exclusive or any breastfeeding, as well as breastfeeding at the time of gluten introduction, did not reduce the risk of developing celiac disease during childhood. […] Given the important role of infections, vaccination has been indicated as a strategy for prevention. In fact, several studies have shown a reduced incidence of disease in subjects vaccinated for Rotavirus. […] The pathogenesis of CD need to be clarified: environmental factors and genetic factors need to be better understood. Prospective studies have much improved our knowledge of the natural history and have provided biomarkers that help to define the different level to which intervene. Primary prevention remains the main goal to achieve, with interventions planned as early as possible even before birth.

• #11 Celiac disease primary prevention – wikidoc

  https://www.wikidoc.org/index.php/Celiac_disease_primary_prevention

  Effective measures for the primary prevention of celiac disease include breastfeeding, delayed introduction of gluten-including diet, and preventing gastrointestinal (GI) infections.[1] […] Infants who were breastfed for periods less than one month were found to be at four times increased risk of having celiac disease and those who were breastfed for periods less than three months had five times increased risk.[2] […] Six months of exclusive breastfeeding were associated with delayed onset of symptoms of celiac disease and improved outcome of the disease.[4] […] Continued breastfeeding decreases the amount of gluten delivered to the intestine and protects against GI infections (which are believed to increase the risk of disease).[3] […] Following these measures is believed to decrease the incidence of new cases in Sweden.[2][5][6][7] […] GI infections are believed to increase the permeability of the GI mucosa which allows for penetration of antigens. Also, some hypotheses suggest the disease might be viral in origin (namely rotavirus)

• #12 Azthena logo with the word Azthena

  https://www.news-medical.net/news/20200928/Early-introduction-of-gluten-may-be-an-effective-celiac-disease-prevention-strategy.aspx

  Introducing high doses of gluten from four months of age into infants’ diets could prevent them from developing celiac disease, a study has found. […] The results suggest the early introduction of high-dose gluten may be an effective prevention strategy for the disease, though researchers say further studies are needed before being applied in practice. […] This is the first study that provides evidence that early introduction of significant amounts of wheat into a baby’s diet before six months of age may prevent the development of celiac disease. […] Early introduction of gluten and its role in the prevention of celiac disease should be explored further, using the results of the EAT Study as the basis for larger clinical trials to definitively answer this question.

• #13 Celiac Disease | Boston Children’s Hospital

  https://www.childrenshospital.org/conditions/celiac-disease

  This is an area of ongoing research. There has been some evidence that introducing gluten while breastfeeding (and not before 4 months of age) may be helpful, and a rotavirus vaccine may help to prevent an infection that might trigger celiac disease. […] The only treatment for celiac disease is strict adherence to a gluten-free diet for life. This will allow your child’s intestines to heal, and, in almost all cases, eliminate the symptoms related to celiac disease.

• #14 Babies Could Hold the Key to Personalized Prevention of Celiac Disease

  https://www.massgeneral.org/children/celiac-disease/babies-could-hold-the-key-to-personalized-prevention-of-celiac-disease

  Babies Could Hold the Key to Personalized Prevention of Celiac Disease […] The risk of developing CD for these infants is increased by 8-25% over that of the general population. […] A main aim of the study is to track the development of the gut microbiome by collecting the child’s stool samples and watching how the microbial communities evolve over time. We hope to identify a distinct microbial pattern that will allow us to predict who will develop CD before it happens so that we can learn how to prevent it.

• #15 Coeliac disease | healthdirect

  https://www.healthdirect.gov.au/coeliac-disease

  Coeliac disease can’t be cured, but it can be managed by following a strict lifelong gluten-free diet. […] For help learning how to maintain a gluten-free diet contact an Accredited Practicing Dietitian or Coeliac Australia. […] It is not possible to prevent coeliac disease. Factors such as when you give children gluten for the first time and how long you breastfeed haven’t been shown to affect a child’s lifelong risk of developing coeliac disease. […] However, early diagnosis and treatment can reduce the chance of experiencing complications of coeliac disease. […] Early diagnosis and treatment of coeliac disease significantly reduces the risk of developing most of these complications.

• #16

  https://myhealth.alberta.ca/Health/aftercareinformation/pages/conditions.aspx?hwid=abp7938

  Celiac disease causes damage to the small intestine. This makes it hard for the body to absorb vitamins and other nutrients. You cannot prevent celiac disease. But you can stop and reverse the damage to the small intestine by eating a strict gluten-free diet. […] Eat a gluten-free diet to prevent symptoms and damage to the small intestine. Even a small amount of gluten may cause damage. […] Avoid all foods that contain wheat, rye, and barley. Foods that are often made with these grains include bread, bagels, pasta, pizza, malted breakfast cereals, and crackers. […] Health professionals vary in their long-term recommendations regarding eating foods with oats. But most agree it is safe to eat oats labelled as gluten-free.

• #17 Celiac Disease – Gastrointestinal Disorders – Merck Manual Professional Edition

  https://www.merckmanuals.com/professional/gastrointestinal-disorders/malabsorption-syndromes/celiac-disease

  Celiac disease involves an inflammatory response to gluten that causes villous atrophy and malabsorption. […] Instruct the patient to follow a gluten-free diet and replace any vitamin or mineral deficiencies. […] Treatment of celiac disease is a gluten-free diet (avoiding foods containing wheat, rye, or barley). Gluten is widely used in commercially prepared foods, so patients need a detailed list of foods to avoid. […] Adherence to a gluten-free diet can significantly reduce the risk of cancer.

• #18

  https://www2.hse.ie/conditions/coeliac-disease/treatment/

  Coeliac disease is usually treated by cutting out foods that contain gluten. […] If you have coeliac disease, you must give up all sources of gluten for life. If you don’t, your symptoms will return. This will cause long-term damage to your health. […] Eating gluten often increases the risk of osteoporosis and cancer in later life. […] Many gluten-free alternatives are available. This includes pasta, pizza bases and bread. […] By law, food labelled as gluten-free cannot contain more than 20mg/kg of gluten. […] For most people with coeliac disease, trace amounts of gluten will not cause a problem. But for a small number of people, they will. These people need to have a diet completely free from cereals. […] Do not add gluten into your baby’s diet before they’re 6 months old. […] If you have coeliac disease, foods containing gluten should get introduced gradually. This needs to be monitored.

• #19 Celiac Disease

  https://mydoctor.kaiserpermanente.org/mas/structured-content/Condition_Celiac_Disease.xml?co=%2Fregions%2Fmas

  There’s no cure for celiac disease. Surgery isn’t a treatment option. […] But your symptoms can be reduced or even eliminated by following a gluten-free diet. […] For most people, this diet stops symptoms, heals intestinal damage, and prevents further damage. You often begin to feel better within weeks of starting the diet. Usually the small intestine heals completely in 6 to 18 months. […] For a small number of people, symptoms don’t decrease with a gluten-free diet. In these rare cases, we may prescribe medications to suppress the immune system. […] Following a gluten-free diet means that you avoid all foods that contain wheat (including spelt, triticale, and kamut), rye, and barley. […] If you have celiac disease, you’ll need to stick to a gluten-free diet for the rest of your life. You can still enjoy a balanced diet. Include foods that are gluten-free such as: […] Being gluten-free can require a bit of research and practice. […] If you accidentally eat gluten, we recommend limiting your exposure by carefully avoiding other gluten foods.

• #20

  https://www.nhs.uk/conditions/coeliac-disease/treatment/

  Coeliac disease is treated by excluding foods that contain gluten from your diet. […] If you have coeliac disease, you must stop eating all sources of gluten for life. […] A dietitian can help you identify which foods are safe to eat and which are not. […] It’s important to always check the labels on the foods you buy. […] By law, food labelled as gluten-free can contain no more than 20 parts per million (ppm) of gluten. […] Do not introduce gluten into your baby’s diet before they’re 6 months old. […] As well as eliminating foods that contain gluten from your diet, there are other treatments available for coeliac disease. […] A GP or dietitian may also recommend taking vitamin and mineral supplements if you need them, for example for iron deficiency anaemia. […] If you have dermatitis herpetiformis (an itchy rash that can be caused by gluten intolerance), cutting gluten out of your diet should help.

• #21 Celiac Disease: Diagnosis and Management | AAFP

  https://www.aafp.org/pubs/afp/issues/2014/0115/p99.html

  The dietary threshold to promote healing of intestinal inflammation in celiac disease has been found to be less than 50 mg of gluten per day. […] Dietary education should focus on identifying hidden sources of gluten, planning balanced meals, reading labels, grocery shopping, dining out, and dining during travel. […] An empiric trial of a gluten-free diet without a biopsy is not recommended because symptoms of other disorders can improve in patients following this diet.

• #22 Coeliac disease and gluten sensitivity | Better Health ChannelExternal LinkExternal LinkExternal LinkExternal LinkExternal LinkExternal LinkExternal LinkExternal LinkExternal LinkExternal LinkExternal LinkExternal LinkExternal LinkExternal LinkExternal Li

  https://www.betterhealth.vic.gov.au/health/conditionsandtreatments/coeliac-disease-and-gluten-sensitivity

  Under mandatory labelling standards, all ingredients and food additives derived from wheat, rye, barley, or oats must be declared in the ingredient list of foods sold in Australia. The use of an allergen summary statement is also now mandatory; ‘gluten’ must be declared as ‘Contains gluten’, if present. […] If you are diagnosed with coeliac disease, ask your GP (doctor) and pharmacist about making sure that any medicines you are taking orally are suitable.

• #23 Best Celiac Disease Treatment Options | North Shore Gastroenterology

  https://www.northshoregastro.org/2022/10/07/the-best-celiac-disease-treatment-options/

  People with celiac disease are more likely to develop anemia and nutritional deficiencies because the gut inflammation associated with the condition can result in damaged villi. […] Medications, such as steroids, are recommended to control inflammation in people who have severely damaged small intestines or have refractory celiac disease. These medications ease the inflammation of the intestine while it heals.

• #24 Celiac Disease Treatment – Medications, Self-Care, Therapies, Prevention, Specialists

  https://www.webmd.com/digestive-disorders/celiac-disease/celiac-disease-treatment

  The only way to manage the symptoms of celiac disease is to eat a strict gluten-free diet. Eating foods without gluten lets your small intestine heal, and stops future problems and inflammation. […] Once you start a gluten-free diet, your intestines should recover and you should be able to absorb these nutrients again. But talk to your doctor to see if you need to take a gluten-free multivitamin or supplement.

• #25 Drugs for Celiac Disease May Be on the Horizon | Columbia University Irving Medical Center

  https://www.cuimc.columbia.edu/news/drugs-celiac-disease-may-be-horizon

  The only safe and effective treatment for celiac disease is to avoid food and drinks that contain gluten, a protein found naturally in wheat, barley, and rye. […] For these reasons, many companies and researchers are looking for drugs to treat celiac disease in addition toor instead ofthe gluten-free diet. […] Some of the candidates work by preventing the consequences of accidental gluten exposure. […] A second category of drugs attempts to re-educate the patients immune system so it no longer reacts to gluten. […] If found to be effective, this category of medication may allow people with celiac disease to eat gluten without harmful consequences. […] The number of drugs in development and the variety of mechanisms make it likely that one of these approaches will allow for a safe and effective non-dietary therapy to emerge, he says.

• #26 Transcriptomic analysis of intestine following administration of a transglutaminase 2 inhibitor to prevent gluten-induced intestinal damage in celiac disease | Nature Immunology

  https://www.nature.com/articles/s41590-024-01867-0

  Transglutaminase 2 (TG2) plays a pivotal role in the pathogenesis of celiac disease (CeD) by deamidating dietary gluten peptides, which facilitates antigenic presentation and a strong anti-gluten T cell response. […] At the transcriptome level, orally administered ZED1227 effectively prevented gluten-induced intestinal damage and inflammation, providing molecular-level evidence that TG2 inhibition is an effective strategy for treating CeD. […] Thus, adjunctive pharmacological therapy, together with a strict GFD, is needed to efficiently treat CeD. […] TG2, being crucial for CeD pathogenesis, is a pertinent target for therapy, and this approach was recently tested in a phase 2, randomized, double-blind, placebo-controlled, dose-finding gluten challenge trial using the oral TG2 inhibitor ZED1227.

• #27 World First Celiac Disease Treatment Inbound? – BioTechniques

  https://www.biotechniques.com/drug-discovery-development/is-this-inhibitor-the-future-of-celiac-disease-treatment/

  The efficacy of a novel therapeutic candidate for celiac disease has been validated at the molecular level, marking an initial step towards the first pharmaceutical intervention for the disease. […] There are currently no interventions for this disease beyond a gluten-free diet (GFD). Whats more, even in celiac patients who strictly avoid gluten, evidence has shown that markers of intestinal damage are still present and the expression of nutrient-absorbing proteins is reduced, suggesting that hidden gluten can still make its way into their diet. […] Previous studies have revealed that the TG2 inhibitor ZED1227 can prevent gluten-induced damage in people with celiac disease; however, its molecular impacts have not been revealed. […] By measuring gene activity, we found that orally ingested ZED1227 effectively prevented gluten-induced intestinal mucosal damage and inflammation. […] Viiri is excited by the potential of ZED1227, stating that, it is a strong drug candidate that could potentially be used in conjunction with a gluten-free diet.

• #28 Transcriptomic analysis of intestine following administration of a transglutaminase 2 inhibitor to prevent gluten-induced intestinal damage in celiac disease | Nature Immunology

  https://www.nature.com/articles/s41590-024-01867-0

  Here, we sought to assess the efficacy of ZED1227 in preventing gluten-induced mucosal damage at the transcriptomic level. […] Overall, our transcriptomic findings strongly support the results of the clinical trial with ZED1227, which demonstrated that the inhibition of TG2 activity can efficiently and specifically prevent gluten-induced mucosal damage. […] Our analysis also suggests that, based on HLA-DQ2.5 genetics, the dose or dose interval of ZED1227 may have to be adjusted for optimal efficacy, but larger sample sizes are required to confirm this assumption. […] Thus, an adjunctive TG2 inhibition-based therapy combined with a GFD would especially benefit highly gluten-sensitive individuals (possibly carrying a homozygous HLA-DQ genotype) by providing protection against intestinal damage that can occur even in a low-gluten environment.

• #29 New treatment may reverse celiac disease – Northwestern Now

  https://news.northwestern.edu/stories/2019/10/new-treatment-may-reverse-celiac-disease/

  Results of a new phase 2 clinical trial using technology developed at Northwestern Medicine show it is possible to induce immune tolerance to gluten in individuals with celiac disease. The findings may pave the way for treated celiac patients to eventually tolerate gluten in their diet. […] The technology is a biodegradable nanoparticle containing gluten that teaches the immune system the antigen (allergen) is safe. […] Celiac patients treated with the COUR nanoparticle, CNP-101, showed 90% less immune inflammation response than untreated patients. By stopping the inflammatory response, CNP-101 showed the capacity to protect the intestines from gluten related injury. […] Doctors can only prescribe gluten avoidance, which is not always effective and carries a heavy social and economic toll for celiac patients, Miller said. […] CNP-101 does not suppress the immune system but reverses the course of disease. […] This makes celiac disease a perfect condition to address using this exciting nanoparticle induced immune tolerance approach.

• #30

  https://penntoday.upenn.edu/news/penn-medicine-pursuing-vaccines-stop-celiac-disease

  Currently, theres no treatment for celiac disease aside from avoiding gluten. […] For diseases like COVID, you want to induce an infection-fighting response; for celiac disease, we want to stop the immune response already happening in the body. […] The idea is to make what experts call a tolerizing vaccine, or a vaccine that would allow someones body to tolerate the thing its reacting to; in this case, that would be the gluten protein.

• #31 Barinthus Bio Initiates Phase 1 Clinical Trial of VTP-1000

  https://www.globenewswire.com/news-release/2024/09/24/2952091/0/en/Barinthus-Bio-Initiates-Phase-1-Clinical-Trial-of-VTP-1000-for-the-Treatment-of-Celiac-Disease.html

  Investigational immunotherapy candidate, VTP-1000, seeks to address significant unmet need in people with celiac disease. […] Celiac disease remains an area that currently does not have any approved treatments. VTP-1000 aims to restore immune system tolerance to gluten and we are very excited to see VTP-1000 and the SNAP-TI platform in the clinic for the first time, added Dr. Nadge Pelletier, Chief Scientific Officer of Barinthus Bio, Restoring the correct balance of regulatory over pathogenic effector T cells aims to prevent or reduce inflammation in the small intestine following exposure to gluten. […] Celiac disease is an area of high unmet need with no currently approved treatments; instead, people with celiac disease are advised to strictly avoid consuming gluten, which can be difficult due to the presence of gluten in many foods and cross-contamination of food production surfaces.

• #32 Celiac disease diet: Avoiding foods that contain gluten – Harvard Health

  https://www.health.harvard.edu/diseases-and-conditions/celiac-disease-diet-avoiding-foods-that-contain-gluten

  Celiac disease is a chronic digestive and immune disorder in which consuming foods containing gluten triggers an immune reaction that causes gastrointestinal discomfort and, over time, damages the small intestine. […] For this reason, it’s important for people with celiac disease to follow a strict diet that excludes gluten. […] While there is no „cure” for celiac disease, avoiding gluten can prevent recurring symptoms. A gluten-free diet can also relieve celiac disease symptoms and even allow damage to the small intestine to heal. […] Because avoiding gluten is the only way to prevent symptoms and intestinal damage from celiac disease from returning, people with celiac disease must follow a gluten-free diet for life. […] It is important to adhere to a gluten-free diet if you have celiac disease. If left untreated, celiac disease can lead to severe malnutrition and can put you at risk of serious consequences, including osteoporosis (thin bones), anemia, infertility, liver disease, neuropathy (damaged nerves), and seizures.

• #33 Celiac Disease | MedlinePlus

  https://medlineplus.gov/celiacdisease.html

  Celiac disease is triggered by eating foods that contain gluten. Gluten is a protein found in wheat, barley, rye, and other grains. […] The treatment for celiac disease is following a gluten-free diet for the rest of your life. Sticking with a gluten-free diet will treat or prevent many of the symptoms and other health problems caused by celiac disease. In most cases, it can also heal damage in the small intestine and prevent more damage.

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