Materiały źródłowe

• #1

  https://www.nhs.uk/conditions/behcets-disease/treatment/

  There’s currently no cure for Behet’s disease, but a number of treatments can help to relieve symptoms and reduce the risk of serious complications. […] Once a diagnosis of Behet’s disease has been confirmed, you’ll usually be referred to several different specialists who have experience of treating the condition. They’ll help draw up a specific treatment plan for you. […] Your treatment plan usually involves the use of a combination of different medicines. Depending on the type and severity of your symptoms, you may only need to take medicines when you have a flare-up. […] Alternatively, you may have to take medicines on a long-term basis to stop serious complications developing, such as vision loss. […] You may also be offered emotional, employment and welfare support, as well as information about support groups you can join.

• #1 Behcet’s syndrome: providing integrated care | JMDH

  https://www.dovepress.com/behcets-syndrome-providing-integrated-care-peer-reviewed-fulltext-article-JMDH

  Multidisciplinary patient care is essential for the management of BS, as it is for other multisystem diseases. Rheumatologists, dermatologists, ophthalmologists, neurologists, cardiovascular surgeons and gastroenterologists are members of the multidisciplinary team. […] A multidisciplinary team of rheumatologists, dermatologists, ophthalmologists, neurologists, cardiovascular surgeons and gastroenterologists, often led by rheumatologists, take part in the management of patients with BS. […] The treatment should be individualized for each patient. The main principles of treatment are to suppress inflammation quickly during acute attacks in order to prevent damage and to prevent relapses with immunosuppressives if needed. […] The treatment of mucocutaneous lesions depends on the severity of each lesion. For isolated OUs and GUs, topical measures are usually sufficient.

• #1 Behcet Disease Treatment & Management: Approach Considerations, Medical Care, Surgical Care

  https://emedicine.medscape.com/article/329099-treatment

  The goals of therapy in Behet disease are to suppress inflammation and reduce the frequency and severity of recurrences. To be effective, treatment must be started early. The sites and extent of involvement and the severity of disease determine the choice of medication. […] The treatment approach depends on the individual patient, severity of disease, and major organ involvement. […] As disease activity subsides, taper medications to the lowest dose that effectively controls disease activity. Inpatient care is based on individual organ-system involvement. Individualize the transfer situation for each patient based on the specifics of organ-system involvement. […] For oral and genital ulcerations, topical corticosteroids or sucralfate solution are first-line therapy for mild isolated ulcerations.

• #1

  https://www.nhs.uk/conditions/behcets-disease/treatment/

  For severe ulcers and lesions that do not respond to other treatments, other immunosuppressant tablets or biological therapies may be recommended. […] Because of the potential risk of vision loss in serious cases, any eye inflammation caused by Behet’s disease should be carefully monitored by an ophthalmologist. […] Treatment for eye problems often involves taking azathioprine and corticosteroid medicines, although corticosteroid eyedrops may also be useful. […] In severe cases where these treatments have not helped, immunosuppressant medicines, such as azathioprine or ciclosporin, may be recommended. […] For people with joint pain caused by Behet’s disease, conventional painkillers such as paracetamol and non-steroidal anti-inflammatory drugs (NSAIDs) may sometimes help relieve the pain.

• #1 Behcet Disease Treatment & Management: Approach Considerations, Medical Care, Surgical Care

  https://emedicine.medscape.com/article/329099-treatment

  For severe eye disease (significant drop in visual acuity, retinal vasculitis, or macular involvement), either cyclosporine or infliximab may be used in combination with azathioprine and corticosteroids. […] An expert panel has recommended considering infliximab and adalimumab as first-line immunomodulatory agents for the treatment of ocular manifestations. […] Interferon-alfa, alone or in combination with corticosteroids, can be a second choice in severe ocular Behet disease. […] For gastrointestinal lesions, treatment alternatives based on expert opinion are as follows: Minosalicylate (5-ASA) derivatives (eg, sulfasalazine or mesalamine), systemic corticosteroids, azathioprine, tumor necrosis factor (TNF-) antagonists, thalidomide. […] Arthritis may respond to prednisone, local corticosteroid injections, nonsteroidal anti-inflammatory drugs (NSAIDs), and colchicine.

• #1 Behçet’s Disease (Causes, Symptoms, and Treatment)

  https://patient.info/doctor/behcets-disease-pro

  Surgery This may be required for: Gastrointestinal complications – eg, perforation and peritonitis. Aneurysms or ischaemic tissues affected by vasculitis or thrombosis. Ventricular aneurysms and coronary thrombosis. Eye involvement – eg, glaucoma, cataracts or retinal detachment. CNS aneurysms or clots.

• #1 Behçet’s Disease (Causes, Symptoms, and Treatment)

  https://patient.info/doctor/behcets-disease-pro

  Behet’s disease treatment and management The aim of treatment is to prevent long-term damage. The most severe manifestation of Behet’s disease present in the patient usually determines the choice of treatment. Local therapy: Topical corticosteroids (eg, triamcinolone paste) are effective for oral or genital ulcerations if they are applied during the prodromal stage of ulceration when the symptoms are more mild. Systemic manifestations: Lesions resistant to local measures may require systemic treatment. Systemic treatments are usually given for 1-2 years. They may be given longer for those with gastrointestinal involvement. Patients with eye involvement need early and more aggressive treatment, usually with a brief course of corticosteroid with a longer-term immunosuppressant (eg, azathioprine). Patients with CNS involvement require the most aggressive treatment, usually with a corticosteroid plus either azathioprine, cyclophosphamide, or a TNF-alpha inhibitor. Continual use of immunosuppressive medications may be required to suppress disease. Corticosteroids are effective for acute manifestations but there is no evidence of any beneficial effect on disease progression. Biotherapy approaches, including interferon- (IFN-), tumour necrosis factor- (TNF-) antagonists, and other agents that target interleukins and their receptors, have shown promising results in the treatment of patients with refractory Behet’s disease. Mucocutaneous lesions and joint involvement: These may respond to non-steroidal anti-inflammatory drugs, prednisolone, levamisole, colchicine, dapsone, or sulfapyridine and thalidomide. In most patients, arthritis can be managed with colchicine. Local corticosteroid injections may also be used. Immunosuppressive therapy with azathioprine may be effective. Major vessel disease: Vasculitis is treated with immunosuppressive medication. Prevention of acute deep vein thrombosis is by using immunosuppressive agents rather than anticoagulants. If a venous thrombotic event does occur, however, warfarin is usually given. For pulmonary and peripheral arterial aneurysms, immunosuppressants and corticosteroids are usually given.

• #1 Behcet Disease Treatment & Management: Approach Considerations, Medical Care, Surgical Care

  https://emedicine.medscape.com/article/329099-treatment

  Central nervous system (CNS) disease is usually treated with systemic corticosteroids, interferon-alfa, azathioprine, cyclophosphamide, methotrexate, and TNF- antagonists. […] Treatment of major-vessel disease with thrombotic events is with systemic anticoagulation in addition to corticosteroids, azathioprine, cyclophosphamide, or cyclosporine. […] TNF- antagonists are increasingly used and have become standard treatment of Behet disease that is inadequately controlled by standard immunosuppressive regimens. […] Infliximab has been most widely studied, but adalimumab has proved successful in cases refractory to both conventional therapy and infliximab. […] Surgery may also be considered in the following circumstances: Pulmonary aneurysms and areas that incur ischemic damage due to vasculitis or thrombosis may require resection. […] Activity is suggested as tolerated and may be limited owing to systemic symptoms or arthritis.

• #1 Behcet’s disease – Gundry Health – A holistic approach to clinical care. – Dr. Steven Gundry

  https://gundryhealth.com/behcets-disease/

  Treatment for Behcets disease is focused on reducing inflammation and preventing complications. […] Working closely with a healthcare provider to develop a treatment plan appropriate for the individuals needs is essential. In some cases, treatment may involve a combination of medications and lifestyle changes include quitting smoking, maintaining a healthy weight, and engaging in regular physical activity. […] Treatment for Behcets disease is focused on reducing inflammation and preventing complications and may include corticosteroids, immunosuppressive medications, biologics, and antibiotics. Most people with Behcets disease are able to lead everyday lives with proper treatment and management.

• #1 Behcet’s Disease Recovery & Support | NYU Langone Health

  https://nyulangone.org/conditions/behcets-disease/support

  There is no cure for Behcets disease, but treatments can keep symptoms under control. […] Therapies are most effective when started early and monitored regularly. […] The goal of treatment with medication is to get you into remission. […] If your symptoms are under control with medication and eventually subside, your doctor may slowly take you off the medication, with the goal of stopping treatment when Behets disease enters a remission phase. […] Some people, however, need long-term medication to control the symptoms of Behets disease. […] You can expect to follow up with your rheumatologist on a regular basis to ensure the treatment is working and to manage any side effects of medication, such as fatigue, high blood pressure, and an increased risk of infection. […] Its important for people with severe symptoms to continue seeing a rheumatologist after treatment is completed. […] Your doctor may want to see you annually for several years to monitor your health and to check for any signs of relapse. […] If Behets disease does flare up, the experts at NYU Langone can immediately treat you and help alleviate your symptoms.

• #1

  https://www.nhs.uk/conditions/behcets-disease/treatment/

  Daily colchicine tablets can also help by reducing the inflammation in your joints. […] In severe cases where these treatments have not helped, azathioprine or biological therapies may be recommended. […] A number of different medicines may be used to help reduce inflammation of the stomach and bowel caused by Behet’s disease, including corticosteroids, immunosuppressants and biological therapies. […] It’s important to discuss plans to have a baby with your care team, who will be able to adjust your treatment plan to make your pregnancy as safe as possible. […] Corticosteroids can be used to help relieve symptoms of neonatal Behet’s disease. The condition usually resolves within 6 to 8 weeks after the birth.

• #1

  https://link.springer.com/article/10.1007/s11926-021-01011-z

  To assess current management of Behcets disease (BD). […] Glucocorticoids are still the main agents for remission-induction and azathioprine the first-line conventional IS in maintenance phase to prevent relapses of major organ involvement. […] Although both conventional IS and biologic agents are effectively used to suppress inflammation in BD, there is still an unmet need for clear therapeutic strategies in the management for different manifestations. Further controlled studies with new biologic agents, anticoagulants and the benefit of concomitant IS usage with biologics are needed to optimize the management of BD.

• #1 Behçet’s Disease, Pathogenesis, Clinical Features, and Treatment Approaches: A Comprehensive Review

  https://pmc.ncbi.nlm.nih.gov/articles/PMC11051811/

  Behets disease is a systemic inflammatory disorder of unknown etiology. […] Diagnosis is primarily clinical due to the lack of a definitive diagnostic test, and management involves a multidisciplinary approach to control inflammation and manage symptoms. […] The management of Behets disease is complex, typically requiring a multidisciplinary approach. […] Treatment strategies primarily aim to control inflammation and manage symptoms, with the choice of therapeutic agents often guided by the specific organ systems involved and the severity of the disease. […] Regular follow-ups are essential to track the course of the disease and the effectiveness of treatment, in addition to pharmacological interventions. […] The chronic and potentially disabling nature of Behets disease also brings pain specialists and mental health professionals to the fore, providing much-needed pain and psychological support. […] Nurses, physical therapists, and patient educators are integral members of the care team, also in keeping a watchful eye on the patients overall status, including any side effects from the medication.

• #1 Relief from Behcet’s Disease Symptoms: Exploring Interventional Pain Treatments | Ortho Sport & Spine Physicians

  https://orthosportandspine.com/blog/relief-from-behcets-disease-symptoms-exploring-interventional-pain-treatments/

  Behcets disease, a chronic condition characterized by inflammation of blood vessels, can lead to various symptoms, including pain and discomfort. Non-surgical methods that we offer at Ortho Sport Spine Physicians can play a crucial role in providing relief and improving the quality of life for individuals dealing with Behcets Disease. The following are treatments we offer to combat the pain associated with Behcets disease. […] Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly prescribed to reduce inflammation and alleviate pain associated with Behcets. […] For more targeted relief, interventional pain treatments include steroid/anesthetic injections. […] Physical therapy plays a crucial role in managing Behcets disease symptoms, focusing on improving flexibility, strength and mobility.

• #1 French recommendations for the management of Behçet’s disease | Orphanet Journal of Rare Diseases | Full Text

  https://ojrd.biomedcentral.com/articles/10.1186/s13023-020-01620-4

  Behets disease is a vascularity of vessels of all calibers that affects the arterial and venous areas. Specialized multi-disciplinary care in an expert center is necessary for this rare disease with very polymorphic expression and requiring extended treatments and lifelong follow-up. The drug treatments for Behets disease essentially depend on the clinical manifestations and target the abatement of inflammation. Colchicine is the first-choice treatment of mucocutaneous and articular involvement. The most serious, ocular, vascular, or neurological involvements require immunomodulating treatment, most often associating systemic corticosteroid therapy with immunosuppressants and biotherapy (anti-TNF), depending on the indication. […] Therapeutic education is indispensable to optimize the care and compliance of the patient with the therapeutic project. The diagnosis of Behets disease is clinical. The pediatric and familial forms may be syndromic (of genetic origin). Severe organ damage (ocular, digestive, neurological, cardiovascular, and pulmonary) requires care by expert centers. A multidisciplinary team is indispensable for the care of Behets disease. […] The use of anticoagulants in treating vascular involvement is disputed but remains recommended; inflammation of the vascular walls is the main cause of Behets disease-related thrombosis.

• #1 Behçet’s Syndrome – Vasculitis Foundation

  https://vasculitisfoundation.org/education/vasculitis-types/behcets-syndrome/

  Living with Behets can be challenging at times. Fatigue, pain, emotional stress, and medication side effects can take a toll on your sense of well-being, affecting relationships, work, and other aspects of your daily life. Sharing your experience with family and friends, connecting with others through a support group, or talking with a mental health professional can help. […] There is no cure for Behets syndrome at this time, but treatment can relieve symptoms and prevent potentially serious complications such as blindness and stroke. Behets can be a chronic disorder with periods of remission and relapse, so most patients need to see a doctor on an ongoing basis.

• #2 Behçet’s Disease, Pathogenesis, Clinical Features, and Treatment Approaches: A Comprehensive Review

  https://pmc.ncbi.nlm.nih.gov/articles/PMC11051811/

  Behets disease is a systemic inflammatory disorder of unknown etiology. […] Diagnosis is primarily clinical due to the lack of a definitive diagnostic test, and management involves a multidisciplinary approach to control inflammation and manage symptoms. […] The management of Behets disease is complex, typically requiring a multidisciplinary approach. […] Treatment strategies primarily aim to control inflammation and manage symptoms, with the choice of therapeutic agents often guided by the specific organ systems involved and the severity of the disease. […] Regular follow-ups are essential to track the course of the disease and the effectiveness of treatment, in addition to pharmacological interventions. […] The chronic and potentially disabling nature of Behets disease also brings pain specialists and mental health professionals to the fore, providing much-needed pain and psychological support. […] Nurses, physical therapists, and patient educators are integral members of the care team, also in keeping a watchful eye on the patients overall status, including any side effects from the medication.

• #2 French recommendations for the management of Behçet’s disease | Orphanet Journal of Rare Diseases | Full Text

  https://ojrd.biomedcentral.com/articles/10.1186/s13023-020-01620-4

  Behets disease is a vascularity of vessels of all calibers that affects the arterial and venous areas. Specialized multi-disciplinary care in an expert center is necessary for this rare disease with very polymorphic expression and requiring extended treatments and lifelong follow-up. The drug treatments for Behets disease essentially depend on the clinical manifestations and target the abatement of inflammation. Colchicine is the first-choice treatment of mucocutaneous and articular involvement. The most serious, ocular, vascular, or neurological involvements require immunomodulating treatment, most often associating systemic corticosteroid therapy with immunosuppressants and biotherapy (anti-TNF), depending on the indication. […] Therapeutic education is indispensable to optimize the care and compliance of the patient with the therapeutic project. The diagnosis of Behets disease is clinical. The pediatric and familial forms may be syndromic (of genetic origin). Severe organ damage (ocular, digestive, neurological, cardiovascular, and pulmonary) requires care by expert centers. A multidisciplinary team is indispensable for the care of Behets disease. […] The use of anticoagulants in treating vascular involvement is disputed but remains recommended; inflammation of the vascular walls is the main cause of Behets disease-related thrombosis.

• #2 Behçet’s Disease (Causes, Symptoms, and Treatment)

  https://patient.info/doctor/behcets-disease-pro

  Behet’s disease treatment and management The aim of treatment is to prevent long-term damage. The most severe manifestation of Behet’s disease present in the patient usually determines the choice of treatment. Local therapy: Topical corticosteroids (eg, triamcinolone paste) are effective for oral or genital ulcerations if they are applied during the prodromal stage of ulceration when the symptoms are more mild. Systemic manifestations: Lesions resistant to local measures may require systemic treatment. Systemic treatments are usually given for 1-2 years. They may be given longer for those with gastrointestinal involvement. Patients with eye involvement need early and more aggressive treatment, usually with a brief course of corticosteroid with a longer-term immunosuppressant (eg, azathioprine). Patients with CNS involvement require the most aggressive treatment, usually with a corticosteroid plus either azathioprine, cyclophosphamide, or a TNF-alpha inhibitor. Continual use of immunosuppressive medications may be required to suppress disease. Corticosteroids are effective for acute manifestations but there is no evidence of any beneficial effect on disease progression. Biotherapy approaches, including interferon- (IFN-), tumour necrosis factor- (TNF-) antagonists, and other agents that target interleukins and their receptors, have shown promising results in the treatment of patients with refractory Behet’s disease. Mucocutaneous lesions and joint involvement: These may respond to non-steroidal anti-inflammatory drugs, prednisolone, levamisole, colchicine, dapsone, or sulfapyridine and thalidomide. In most patients, arthritis can be managed with colchicine. Local corticosteroid injections may also be used. Immunosuppressive therapy with azathioprine may be effective. Major vessel disease: Vasculitis is treated with immunosuppressive medication. Prevention of acute deep vein thrombosis is by using immunosuppressive agents rather than anticoagulants. If a venous thrombotic event does occur, however, warfarin is usually given. For pulmonary and peripheral arterial aneurysms, immunosuppressants and corticosteroids are usually given.

• #2 Behcet Disease Treatment & Management: Approach Considerations, Medical Care, Surgical Care

  https://emedicine.medscape.com/article/329099-treatment

  Colchicine has also been used to prevent mucocutaneous relapse. […] For severe mucocutaneous lesions, systemic corticosteroids, azathioprine, pentoxifylline, dapsone, interferon-alfa, colchicine, and thalidomide have demonstrated benefit. […] Apremilast is a second-line treatment for oral ulcers associated with Behet disease. […] A study that compared TNF- inhibitors and apremilast for the treatment of refractory oral ulcers showed that both are equally effective. […] Cutaneous disease with erythema nodosum is a special circumstance and may be treated with colchicine or dapsone. […] In patients who have a delayed response, glucocorticoids and other immunosuppressive treatments may be used to prevent the progression to ulceration. […] For ocular disease, azathioprine is widely accepted as the initial agent.

• #2

  https://www.nhs.uk/conditions/behcets-disease/treatment/

  For severe ulcers and lesions that do not respond to other treatments, other immunosuppressant tablets or biological therapies may be recommended. […] Because of the potential risk of vision loss in serious cases, any eye inflammation caused by Behet’s disease should be carefully monitored by an ophthalmologist. […] Treatment for eye problems often involves taking azathioprine and corticosteroid medicines, although corticosteroid eyedrops may also be useful. […] In severe cases where these treatments have not helped, immunosuppressant medicines, such as azathioprine or ciclosporin, may be recommended. […] For people with joint pain caused by Behet’s disease, conventional painkillers such as paracetamol and non-steroidal anti-inflammatory drugs (NSAIDs) may sometimes help relieve the pain.

• #2

  https://www.nhs.uk/conditions/behcets-disease/treatment/

  Daily colchicine tablets can also help by reducing the inflammation in your joints. […] In severe cases where these treatments have not helped, azathioprine or biological therapies may be recommended. […] A number of different medicines may be used to help reduce inflammation of the stomach and bowel caused by Behet’s disease, including corticosteroids, immunosuppressants and biological therapies. […] It’s important to discuss plans to have a baby with your care team, who will be able to adjust your treatment plan to make your pregnancy as safe as possible. […] Corticosteroids can be used to help relieve symptoms of neonatal Behet’s disease. The condition usually resolves within 6 to 8 weeks after the birth.

• #2 Behcet’s syndrome: providing integrated care | JMDH

  https://www.dovepress.com/behcets-syndrome-providing-integrated-care-peer-reviewed-fulltext-article-JMDH

  For joint involvement, colchicine is the first-line treatment choice to prevent arthritis attacks. […] Patients with posterior uveitis with or without retinal vasculitis should be treated with immunosuppressive agents such as azathioprine, cyclosporine, interferon-alpha and anti-TNFs. […] Patients with vascular involvement should be treated with immunosuppressives since they have been shown to reduce relapse rate of venous thrombosis when compared to solo anti-coagulation therapy. […] The conventional treatment modalities for the management of GIBS are glucocorticoids, azathioprine, salazopyrine and other 5-aminosalicylic acid derivatives, similar to inflammatory bowel diseases. […] The treatment of acute NBS includes high-dose intravenous methylprednisolone pulses for 710 days followed by gradual oral tapering over 36 months, depending on the relapse severity. […] Patients are usually seen every 36 months depending on the severity of their diseases. The frequency of mucocutaneous lesions and any new manifestations are recorded in each visit. Eye examination is repeated in every visit in patients presenting with ocular involvement.

• #2 Behçet’s Syndrome – Vasculitis Foundation

  https://vasculitisfoundation.org/education/vasculitis-types/behcets-syndrome/

  More severe disease may require immunosuppressive drugs such as methotrexate, azathioprine, cyclosporine, apremilast, and cyclophosphamide. […] Biologics are also an option when Behets is severe. Biologic medications are complex proteins derived from living organisms. They target certain parts of the immune system to control inflammation. Examples used to treat Behets include infliximab, etanercept, adalimumab, and interferon alpha. […] The medications used to treat Behets have potentially serious side effects, such as lowering the body’s ability to fight infection, among others, so it is important to monitor your child’s symptoms and report them to the doctor. Infection prevention is also very important. […] Even with effective treatment and periods of remission, some individuals will experience relapse of Behets—sometimes months or even years after the original symptoms subside. If your initial symptoms return or you develop new ones, report them to your doctor as soon as possible. Regular doctor visits and ongoing monitoring of laboratory and imaging tests are important in detecting relapses early.

• #2 Behcet Syndrome – What You Need to Know

  https://www.drugs.com/cg/behcet-syndrome.html

  Your healthcare provider will examine you and ask about your symptoms. […] Treatment may depend on your symptoms and problems caused by Behcet syndrome. […] You may only need to take medicine during a flare-up. […] You may be given medicine to decrease pain and inflammation. […] Medicine may also be given to prevent your immune system from attacking healthy tissue. […] Rest during a flare-up. […] Apply ice or heat on painful joints. […] Eat soft, bland foods if you have mouth sores. […] Get regular exercise when your symptoms are gone. […] Join a support group. […] You have the right to help plan your care. […] Discuss treatment options with your healthcare providers to decide what care you want to receive.

• #2 Behçet’s Disease – Rare Awareness Rare Education

  https://rareportal.org.au/rare-disease/behcet-disease/

  There may be special considerations for the emergency management of individuals living with Behets disease presenting to emergency departments. […] We are not aware of any clinical care guidelines for Behets disease in Australia. If you know of any relevant care guidelines, please let us know via the Contribute page. […] Regular monitoring is recommended to identify and prevent complications such as blindness. […] Healthcare professionals involved in the treatment of Behets disease may include general practitioners (GP), nephrologists, neurologists, rheumatologists, dermatologists, ophthalmologists, gastroenterologists, pulmonologists, and vascular physicians. The need for different healthcare professionals may change over a persons lifetime and extend beyond those listed here.

• #2 Behçet’s disease: Treatment, lifestyle tips, and causes

  https://www.medicalnewstoday.com/articles/310313

  There is no cure for Behets disease, but some therapies and lifestyle choices can help relieve symptoms. […] Once a person has a diagnosis of Behets disease, a team of health professionals team will make recommendations about treatment options. […] The team may include an oral health specialist, a dermatologist, ophthalmologist and a rheumatologist, among others. […] Patients should discuss treatment options with their healthcare provider. […] For this reason, it is best for any pregnancy to be planned and discussed first with a health provider. […] Any supplements or complementary therapies should first be discussed with a health provider, as these may worsen symptoms or interact with treatment. […] Medication can relieve pain, control symptoms, and it may help reduce the frequency and severity of flares.

• #2 Interdisciplinary Autoimmune Summit

  https://www.healio.com/news/rheumatology/20200713/behcets-disease-remains-largely-unknown-among-physicians

  The rare and complex Behcets disease is often misdiagnosed or undiagnosed, leading to significant, but unnecessary, morbidity, according to a presenter at the 2020 Interdisciplinary Autoimmune Summit. […] Santos described Behcets disease as a chronic, multisystemic inflammatory disorder that is marked primarily by oral and genital ulcers, along with variable vessel vasculitis meaning that it affects arteries and veins that can bring manifestations to all systems of the body, from the skin to the eyes to neurological centers. […] The oral and genital components of the disease can affect daily living, socializing and other associated quality of life (QOL) parameters. This disease affects your ability to eat and talk, Santos said. Vaginal ulcers can lead to sexual dysfunction. […] In general, individuals with Behcets disease frequently report low self-esteem, negative body image, anxiety, fear and tension, according to Santos. He stressed that the chronic, debilitating nature of the condition makes it imperative that clinicians improve in the entire spectrum from diagnosis to treatment. You have to plan your events around manifestations of this disease, he said.

• #2 Behcet’s Disease (+ 6 Natural Ways to Improve Symptoms) – Dr. Axe

  https://draxe.com/health/behcets-disease/

  Behcets disease is known to affect certain organs and tissues including the eyes, mouth, skin, lungs, joints, genitals, brain, and gastrointestinal tract. […] There is no cure for Behcets disease, but conventional Behcets disease treatment aims to relieve specific symptoms. Treatment typically includes topical and oral medications including corticosteroids and other immunosuppressants. […] According to the Mayo Clinic, no cure exists for Behcets disease. If you have a mild form of the condition, your doctor may offer medications to control temporary flares in pain and inflammation. […] Since people with Behcets are prone to mouth sores, it’s very important that they maintain good oral health, which includes regular brushing and flossing. […] Health complications due to Behcets depends upon your individual signs and symptoms of the disease. Anyone with eye symptoms of Behcets disease should see an ophthalmologist on a regular basis since untreated uveitis can result in decreased vision or even blindness.

• #3 Behçet’s Disease, Pathogenesis, Clinical Features, and Treatment Approaches: A Comprehensive Review

  https://pmc.ncbi.nlm.nih.gov/articles/PMC11051811/

  Behets disease is a systemic inflammatory disorder of unknown etiology. […] Diagnosis is primarily clinical due to the lack of a definitive diagnostic test, and management involves a multidisciplinary approach to control inflammation and manage symptoms. […] The management of Behets disease is complex, typically requiring a multidisciplinary approach. […] Treatment strategies primarily aim to control inflammation and manage symptoms, with the choice of therapeutic agents often guided by the specific organ systems involved and the severity of the disease. […] Regular follow-ups are essential to track the course of the disease and the effectiveness of treatment, in addition to pharmacological interventions. […] The chronic and potentially disabling nature of Behets disease also brings pain specialists and mental health professionals to the fore, providing much-needed pain and psychological support. […] Nurses, physical therapists, and patient educators are integral members of the care team, also in keeping a watchful eye on the patients overall status, including any side effects from the medication.

• #3

  https://www.nhs.uk/conditions/behcets-disease/treatment/

  There’s currently no cure for Behet’s disease, but a number of treatments can help to relieve symptoms and reduce the risk of serious complications. […] Once a diagnosis of Behet’s disease has been confirmed, you’ll usually be referred to several different specialists who have experience of treating the condition. They’ll help draw up a specific treatment plan for you. […] Your treatment plan usually involves the use of a combination of different medicines. Depending on the type and severity of your symptoms, you may only need to take medicines when you have a flare-up. […] Alternatively, you may have to take medicines on a long-term basis to stop serious complications developing, such as vision loss. […] You may also be offered emotional, employment and welfare support, as well as information about support groups you can join.

• #3 Behcet Disease Treatment & Management: Approach Considerations, Medical Care, Surgical Care

  https://emedicine.medscape.com/article/329099-treatment

  The goals of therapy in Behet disease are to suppress inflammation and reduce the frequency and severity of recurrences. To be effective, treatment must be started early. The sites and extent of involvement and the severity of disease determine the choice of medication. […] The treatment approach depends on the individual patient, severity of disease, and major organ involvement. […] As disease activity subsides, taper medications to the lowest dose that effectively controls disease activity. Inpatient care is based on individual organ-system involvement. Individualize the transfer situation for each patient based on the specifics of organ-system involvement. […] For oral and genital ulcerations, topical corticosteroids or sucralfate solution are first-line therapy for mild isolated ulcerations.

• #3

  https://www.nhs.uk/conditions/behcets-disease/treatment/

  For severe ulcers and lesions that do not respond to other treatments, other immunosuppressant tablets or biological therapies may be recommended. […] Because of the potential risk of vision loss in serious cases, any eye inflammation caused by Behet’s disease should be carefully monitored by an ophthalmologist. […] Treatment for eye problems often involves taking azathioprine and corticosteroid medicines, although corticosteroid eyedrops may also be useful. […] In severe cases where these treatments have not helped, immunosuppressant medicines, such as azathioprine or ciclosporin, may be recommended. […] For people with joint pain caused by Behet’s disease, conventional painkillers such as paracetamol and non-steroidal anti-inflammatory drugs (NSAIDs) may sometimes help relieve the pain.

• #3 Behcet Disease Treatment & Management: Approach Considerations, Medical Care, Surgical Care

  https://emedicine.medscape.com/article/329099-treatment

  For severe eye disease (significant drop in visual acuity, retinal vasculitis, or macular involvement), either cyclosporine or infliximab may be used in combination with azathioprine and corticosteroids. […] An expert panel has recommended considering infliximab and adalimumab as first-line immunomodulatory agents for the treatment of ocular manifestations. […] Interferon-alfa, alone or in combination with corticosteroids, can be a second choice in severe ocular Behet disease. […] For gastrointestinal lesions, treatment alternatives based on expert opinion are as follows: Minosalicylate (5-ASA) derivatives (eg, sulfasalazine or mesalamine), systemic corticosteroids, azathioprine, tumor necrosis factor (TNF-) antagonists, thalidomide. […] Arthritis may respond to prednisone, local corticosteroid injections, nonsteroidal anti-inflammatory drugs (NSAIDs), and colchicine.

• #3 Behcet Disease Treatment & Management: Approach Considerations, Medical Care, Surgical Care

  https://emedicine.medscape.com/article/329099-treatment

  Central nervous system (CNS) disease is usually treated with systemic corticosteroids, interferon-alfa, azathioprine, cyclophosphamide, methotrexate, and TNF- antagonists. […] Treatment of major-vessel disease with thrombotic events is with systemic anticoagulation in addition to corticosteroids, azathioprine, cyclophosphamide, or cyclosporine. […] TNF- antagonists are increasingly used and have become standard treatment of Behet disease that is inadequately controlled by standard immunosuppressive regimens. […] Infliximab has been most widely studied, but adalimumab has proved successful in cases refractory to both conventional therapy and infliximab. […] Surgery may also be considered in the following circumstances: Pulmonary aneurysms and areas that incur ischemic damage due to vasculitis or thrombosis may require resection. […] Activity is suggested as tolerated and may be limited owing to systemic symptoms or arthritis.

• #3 Behçet’s Disease (Causes, Symptoms, and Treatment)

  https://patient.info/doctor/behcets-disease-pro

  Behet’s disease treatment and management The aim of treatment is to prevent long-term damage. The most severe manifestation of Behet’s disease present in the patient usually determines the choice of treatment. Local therapy: Topical corticosteroids (eg, triamcinolone paste) are effective for oral or genital ulcerations if they are applied during the prodromal stage of ulceration when the symptoms are more mild. Systemic manifestations: Lesions resistant to local measures may require systemic treatment. Systemic treatments are usually given for 1-2 years. They may be given longer for those with gastrointestinal involvement. Patients with eye involvement need early and more aggressive treatment, usually with a brief course of corticosteroid with a longer-term immunosuppressant (eg, azathioprine). Patients with CNS involvement require the most aggressive treatment, usually with a corticosteroid plus either azathioprine, cyclophosphamide, or a TNF-alpha inhibitor. Continual use of immunosuppressive medications may be required to suppress disease. Corticosteroids are effective for acute manifestations but there is no evidence of any beneficial effect on disease progression. Biotherapy approaches, including interferon- (IFN-), tumour necrosis factor- (TNF-) antagonists, and other agents that target interleukins and their receptors, have shown promising results in the treatment of patients with refractory Behet’s disease. Mucocutaneous lesions and joint involvement: These may respond to non-steroidal anti-inflammatory drugs, prednisolone, levamisole, colchicine, dapsone, or sulfapyridine and thalidomide. In most patients, arthritis can be managed with colchicine. Local corticosteroid injections may also be used. Immunosuppressive therapy with azathioprine may be effective. Major vessel disease: Vasculitis is treated with immunosuppressive medication. Prevention of acute deep vein thrombosis is by using immunosuppressive agents rather than anticoagulants. If a venous thrombotic event does occur, however, warfarin is usually given. For pulmonary and peripheral arterial aneurysms, immunosuppressants and corticosteroids are usually given.

• #3 French recommendations for the management of Behçet’s disease | Orphanet Journal of Rare Diseases | Full Text

  https://ojrd.biomedcentral.com/articles/10.1186/s13023-020-01620-4

  Behets disease is a vascularity of vessels of all calibers that affects the arterial and venous areas. Specialized multi-disciplinary care in an expert center is necessary for this rare disease with very polymorphic expression and requiring extended treatments and lifelong follow-up. The drug treatments for Behets disease essentially depend on the clinical manifestations and target the abatement of inflammation. Colchicine is the first-choice treatment of mucocutaneous and articular involvement. The most serious, ocular, vascular, or neurological involvements require immunomodulating treatment, most often associating systemic corticosteroid therapy with immunosuppressants and biotherapy (anti-TNF), depending on the indication. […] Therapeutic education is indispensable to optimize the care and compliance of the patient with the therapeutic project. The diagnosis of Behets disease is clinical. The pediatric and familial forms may be syndromic (of genetic origin). Severe organ damage (ocular, digestive, neurological, cardiovascular, and pulmonary) requires care by expert centers. A multidisciplinary team is indispensable for the care of Behets disease. […] The use of anticoagulants in treating vascular involvement is disputed but remains recommended; inflammation of the vascular walls is the main cause of Behets disease-related thrombosis.

• #3 Behcets Disease | Arthritis Foundation

  https://www.arthritis.org/diseases/behcets-disease

  Behet’s disease is a rare autoimmune disorder that causes the body’s blood vessels to swell. […] The goal of Behet’s treatment is to reduce pain and prevent complications. Doctors may prescribe medicines such as corticosteroids and immunosuppressive drugs to reduce the underlying inflammation. […] In addition to prescribed treatments, people with Behet’s will benefit from rest during outbreaks of lesions or other symptoms. Moderate exercise, such as swimming or walking, are helpful during symptom-free periods.

• #3 Behcet’s syndrome: providing integrated care | JMDH

  https://www.dovepress.com/behcets-syndrome-providing-integrated-care-peer-reviewed-fulltext-article-JMDH

  For joint involvement, colchicine is the first-line treatment choice to prevent arthritis attacks. […] Patients with posterior uveitis with or without retinal vasculitis should be treated with immunosuppressive agents such as azathioprine, cyclosporine, interferon-alpha and anti-TNFs. […] Patients with vascular involvement should be treated with immunosuppressives since they have been shown to reduce relapse rate of venous thrombosis when compared to solo anti-coagulation therapy. […] The conventional treatment modalities for the management of GIBS are glucocorticoids, azathioprine, salazopyrine and other 5-aminosalicylic acid derivatives, similar to inflammatory bowel diseases. […] The treatment of acute NBS includes high-dose intravenous methylprednisolone pulses for 710 days followed by gradual oral tapering over 36 months, depending on the relapse severity. […] Patients are usually seen every 36 months depending on the severity of their diseases. The frequency of mucocutaneous lesions and any new manifestations are recorded in each visit. Eye examination is repeated in every visit in patients presenting with ocular involvement.

• #3

  https://www.nhs.uk/conditions/behcets-disease/treatment/

  Daily colchicine tablets can also help by reducing the inflammation in your joints. […] In severe cases where these treatments have not helped, azathioprine or biological therapies may be recommended. […] A number of different medicines may be used to help reduce inflammation of the stomach and bowel caused by Behet’s disease, including corticosteroids, immunosuppressants and biological therapies. […] It’s important to discuss plans to have a baby with your care team, who will be able to adjust your treatment plan to make your pregnancy as safe as possible. […] Corticosteroids can be used to help relieve symptoms of neonatal Behet’s disease. The condition usually resolves within 6 to 8 weeks after the birth.

• #3

  https://link.springer.com/article/10.1007/s11926-021-01011-z

  To assess current management of Behcets disease (BD). […] Glucocorticoids are still the main agents for remission-induction and azathioprine the first-line conventional IS in maintenance phase to prevent relapses of major organ involvement. […] Although both conventional IS and biologic agents are effectively used to suppress inflammation in BD, there is still an unmet need for clear therapeutic strategies in the management for different manifestations. Further controlled studies with new biologic agents, anticoagulants and the benefit of concomitant IS usage with biologics are needed to optimize the management of BD.

• #3 Behçet’s Syndrome – Vasculitis Foundation

  https://vasculitisfoundation.org/education/vasculitis-types/behcets-syndrome/

  Effective treatment for Behets may require the coordinated efforts and ongoing care of a team of providers and specialists. In addition to a primary care provider, Behets patients may need to see the following specialists: Rheumatologist (joints, muscles, and immune system), Gynecologist (female reproductive system), Urologist (male reproductive system and urinary system), Dermatologist (skin), Ophthalmologist (eyes), Neurologist (brain and nervous system), Pulmonologist (lungs), Gastroenterologist (digestive system) or others as needed. […] The best way to manage your disease is to actively partner with your health care providers. Get to know the members of your health care team. It may be helpful to keep a health care journal to track medications, symptoms, test results and notes from doctor appointments in one place.

• #3 Relief from Behcet’s Disease Symptoms: Exploring Interventional Pain Treatments | Ortho Sport & Spine Physicians

  https://orthosportandspine.com/blog/relief-from-behcets-disease-symptoms-exploring-interventional-pain-treatments/

  Behcets disease, a chronic condition characterized by inflammation of blood vessels, can lead to various symptoms, including pain and discomfort. Non-surgical methods that we offer at Ortho Sport Spine Physicians can play a crucial role in providing relief and improving the quality of life for individuals dealing with Behcets Disease. The following are treatments we offer to combat the pain associated with Behcets disease. […] Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly prescribed to reduce inflammation and alleviate pain associated with Behcets. […] For more targeted relief, interventional pain treatments include steroid/anesthetic injections. […] Physical therapy plays a crucial role in managing Behcets disease symptoms, focusing on improving flexibility, strength and mobility.

• #3 Behçet’s Syndrome – Vasculitis Foundation

  https://vasculitisfoundation.org/education/vasculitis-types/behcets-syndrome/

  More severe disease may require immunosuppressive drugs such as methotrexate, azathioprine, cyclosporine, apremilast, and cyclophosphamide. […] Biologics are also an option when Behets is severe. Biologic medications are complex proteins derived from living organisms. They target certain parts of the immune system to control inflammation. Examples used to treat Behets include infliximab, etanercept, adalimumab, and interferon alpha. […] The medications used to treat Behets have potentially serious side effects, such as lowering the body’s ability to fight infection, among others, so it is important to monitor your child’s symptoms and report them to the doctor. Infection prevention is also very important. […] Even with effective treatment and periods of remission, some individuals will experience relapse of Behets—sometimes months or even years after the original symptoms subside. If your initial symptoms return or you develop new ones, report them to your doctor as soon as possible. Regular doctor visits and ongoing monitoring of laboratory and imaging tests are important in detecting relapses early.

• #3 Behçet’s Syndrome – Vasculitis Foundation

  https://vasculitisfoundation.org/education/vasculitis-types/behcets-syndrome/

  Living with Behets can be challenging at times. Fatigue, pain, emotional stress, and medication side effects can take a toll on your sense of well-being, affecting relationships, work, and other aspects of your daily life. Sharing your experience with family and friends, connecting with others through a support group, or talking with a mental health professional can help. […] There is no cure for Behets syndrome at this time, but treatment can relieve symptoms and prevent potentially serious complications such as blindness and stroke. Behets can be a chronic disorder with periods of remission and relapse, so most patients need to see a doctor on an ongoing basis.

• #3 Behcet’s Disease (+ 6 Natural Ways to Improve Symptoms) – Dr. Axe

  https://draxe.com/health/behcets-disease/

  According to the American Behcets Disease Association, Behcets Disease affects different parts of the body, therefore, it is likely patients will have different doctors. It will be helpful to have a primary care physician in order to coordinate treatment and monitor care. Communication among various physicians is important in regards to clinical symptoms and treatment options.

• #4

  https://www.nhs.uk/conditions/behcets-disease/treatment/

  There’s currently no cure for Behet’s disease, but a number of treatments can help to relieve symptoms and reduce the risk of serious complications. […] Once a diagnosis of Behet’s disease has been confirmed, you’ll usually be referred to several different specialists who have experience of treating the condition. They’ll help draw up a specific treatment plan for you. […] Your treatment plan usually involves the use of a combination of different medicines. Depending on the type and severity of your symptoms, you may only need to take medicines when you have a flare-up. […] Alternatively, you may have to take medicines on a long-term basis to stop serious complications developing, such as vision loss. […] You may also be offered emotional, employment and welfare support, as well as information about support groups you can join.

• #4 Behcet’s syndrome: providing integrated care | JMDH

  https://www.dovepress.com/behcets-syndrome-providing-integrated-care-peer-reviewed-fulltext-article-JMDH

  Multidisciplinary patient care is essential for the management of BS, as it is for other multisystem diseases. Rheumatologists, dermatologists, ophthalmologists, neurologists, cardiovascular surgeons and gastroenterologists are members of the multidisciplinary team. […] A multidisciplinary team of rheumatologists, dermatologists, ophthalmologists, neurologists, cardiovascular surgeons and gastroenterologists, often led by rheumatologists, take part in the management of patients with BS. […] The treatment should be individualized for each patient. The main principles of treatment are to suppress inflammation quickly during acute attacks in order to prevent damage and to prevent relapses with immunosuppressives if needed. […] The treatment of mucocutaneous lesions depends on the severity of each lesion. For isolated OUs and GUs, topical measures are usually sufficient.

• #4 Behcet’s Disease: What Dental Hygienists Should Know & Look For – Today’s RDH

  https://www.todaysrdh.com/behcets-disease-what-dental-hygienists-should-know-look-for/

  Behcets disease is an autoimmune disorder which attacks the blood vessels and creates inflammation. […] Behcets disease is not contagious and can be treated. Most popular treatments are medications such as corticosteroids and immunosuppressive medications. Other medications used to treat sight-specific issues are eye drops, ointment for sores, and mouthwash for mouth ulcers. […] Oral manifestations of Behcets disease are mouth ulcers. […] It is important to give patients instructions to avoid high citrus diet intake to lessen the frequency of the sores as much as possible. Mouthwashes containing Colchicine, Xylocaine or Lidocaine, and Benadryl are prescribed or recommended to help temporarily relieve pain. […] Along with medications, this can be a manageable disease and is treatable.

• #4

  https://www.nhs.uk/conditions/behcets-disease/treatment/

  For severe ulcers and lesions that do not respond to other treatments, other immunosuppressant tablets or biological therapies may be recommended. […] Because of the potential risk of vision loss in serious cases, any eye inflammation caused by Behet’s disease should be carefully monitored by an ophthalmologist. […] Treatment for eye problems often involves taking azathioprine and corticosteroid medicines, although corticosteroid eyedrops may also be useful. […] In severe cases where these treatments have not helped, immunosuppressant medicines, such as azathioprine or ciclosporin, may be recommended. […] For people with joint pain caused by Behet’s disease, conventional painkillers such as paracetamol and non-steroidal anti-inflammatory drugs (NSAIDs) may sometimes help relieve the pain.

• #4 Behcet Disease Treatment & Management: Approach Considerations, Medical Care, Surgical Care

  https://emedicine.medscape.com/article/329099-treatment

  For severe eye disease (significant drop in visual acuity, retinal vasculitis, or macular involvement), either cyclosporine or infliximab may be used in combination with azathioprine and corticosteroids. […] An expert panel has recommended considering infliximab and adalimumab as first-line immunomodulatory agents for the treatment of ocular manifestations. […] Interferon-alfa, alone or in combination with corticosteroids, can be a second choice in severe ocular Behet disease. […] For gastrointestinal lesions, treatment alternatives based on expert opinion are as follows: Minosalicylate (5-ASA) derivatives (eg, sulfasalazine or mesalamine), systemic corticosteroids, azathioprine, tumor necrosis factor (TNF-) antagonists, thalidomide. […] Arthritis may respond to prednisone, local corticosteroid injections, nonsteroidal anti-inflammatory drugs (NSAIDs), and colchicine.

• #4 Behcet Disease Treatment & Management: Approach Considerations, Medical Care, Surgical Care

  https://emedicine.medscape.com/article/329099-treatment

  Central nervous system (CNS) disease is usually treated with systemic corticosteroids, interferon-alfa, azathioprine, cyclophosphamide, methotrexate, and TNF- antagonists. […] Treatment of major-vessel disease with thrombotic events is with systemic anticoagulation in addition to corticosteroids, azathioprine, cyclophosphamide, or cyclosporine. […] TNF- antagonists are increasingly used and have become standard treatment of Behet disease that is inadequately controlled by standard immunosuppressive regimens. […] Infliximab has been most widely studied, but adalimumab has proved successful in cases refractory to both conventional therapy and infliximab. […] Surgery may also be considered in the following circumstances: Pulmonary aneurysms and areas that incur ischemic damage due to vasculitis or thrombosis may require resection. […] Activity is suggested as tolerated and may be limited owing to systemic symptoms or arthritis.

• #4 Behçet’s Syndrome – Vasculitis Foundation

  https://vasculitisfoundation.org/education/vasculitis-types/behcets-syndrome/

  Living with Behets can be challenging at times. Fatigue, pain, emotional stress, and medication side effects can take a toll on your sense of well-being, affecting relationships, work, and other aspects of your daily life. Sharing your experience with family and friends, connecting with others through a support group, or talking with a mental health professional can help. […] There is no cure for Behets syndrome at this time, but treatment can relieve symptoms and prevent potentially serious complications such as blindness and stroke. Behets can be a chronic disorder with periods of remission and relapse, so most patients need to see a doctor on an ongoing basis.

• #4 Behcet Syndrome – What You Need to Know

  https://www.drugs.com/cg/behcet-syndrome.html

  Your healthcare provider will examine you and ask about your symptoms. […] Treatment may depend on your symptoms and problems caused by Behcet syndrome. […] You may only need to take medicine during a flare-up. […] You may be given medicine to decrease pain and inflammation. […] Medicine may also be given to prevent your immune system from attacking healthy tissue. […] Rest during a flare-up. […] Apply ice or heat on painful joints. […] Eat soft, bland foods if you have mouth sores. […] Get regular exercise when your symptoms are gone. […] Join a support group. […] You have the right to help plan your care. […] Discuss treatment options with your healthcare providers to decide what care you want to receive.

• #4 Behcet’s syndrome: providing integrated care | JMDH

  https://www.dovepress.com/behcets-syndrome-providing-integrated-care-peer-reviewed-fulltext-article-JMDH

  For joint involvement, colchicine is the first-line treatment choice to prevent arthritis attacks. […] Patients with posterior uveitis with or without retinal vasculitis should be treated with immunosuppressive agents such as azathioprine, cyclosporine, interferon-alpha and anti-TNFs. […] Patients with vascular involvement should be treated with immunosuppressives since they have been shown to reduce relapse rate of venous thrombosis when compared to solo anti-coagulation therapy. […] The conventional treatment modalities for the management of GIBS are glucocorticoids, azathioprine, salazopyrine and other 5-aminosalicylic acid derivatives, similar to inflammatory bowel diseases. […] The treatment of acute NBS includes high-dose intravenous methylprednisolone pulses for 710 days followed by gradual oral tapering over 36 months, depending on the relapse severity. […] Patients are usually seen every 36 months depending on the severity of their diseases. The frequency of mucocutaneous lesions and any new manifestations are recorded in each visit. Eye examination is repeated in every visit in patients presenting with ocular involvement.

• #4 Behçet’s disease: Treatment, lifestyle tips, and causes

  https://www.medicalnewstoday.com/articles/310313

  There is no cure for Behets disease, but some therapies and lifestyle choices can help relieve symptoms. […] Once a person has a diagnosis of Behets disease, a team of health professionals team will make recommendations about treatment options. […] The team may include an oral health specialist, a dermatologist, ophthalmologist and a rheumatologist, among others. […] Patients should discuss treatment options with their healthcare provider. […] For this reason, it is best for any pregnancy to be planned and discussed first with a health provider. […] Any supplements or complementary therapies should first be discussed with a health provider, as these may worsen symptoms or interact with treatment. […] Medication can relieve pain, control symptoms, and it may help reduce the frequency and severity of flares.

• #4 Interdisciplinary Autoimmune Summit

  https://www.healio.com/news/rheumatology/20200713/behcets-disease-remains-largely-unknown-among-physicians

  The rare and complex Behcets disease is often misdiagnosed or undiagnosed, leading to significant, but unnecessary, morbidity, according to a presenter at the 2020 Interdisciplinary Autoimmune Summit. […] Santos described Behcets disease as a chronic, multisystemic inflammatory disorder that is marked primarily by oral and genital ulcers, along with variable vessel vasculitis meaning that it affects arteries and veins that can bring manifestations to all systems of the body, from the skin to the eyes to neurological centers. […] The oral and genital components of the disease can affect daily living, socializing and other associated quality of life (QOL) parameters. This disease affects your ability to eat and talk, Santos said. Vaginal ulcers can lead to sexual dysfunction. […] In general, individuals with Behcets disease frequently report low self-esteem, negative body image, anxiety, fear and tension, according to Santos. He stressed that the chronic, debilitating nature of the condition makes it imperative that clinicians improve in the entire spectrum from diagnosis to treatment. You have to plan your events around manifestations of this disease, he said.

• #4 Behçet’s Disease, Pathogenesis, Clinical Features, and Treatment Approaches: A Comprehensive Review

  https://pmc.ncbi.nlm.nih.gov/articles/PMC11051811/

  Behets disease is a systemic inflammatory disorder of unknown etiology. […] Diagnosis is primarily clinical due to the lack of a definitive diagnostic test, and management involves a multidisciplinary approach to control inflammation and manage symptoms. […] The management of Behets disease is complex, typically requiring a multidisciplinary approach. […] Treatment strategies primarily aim to control inflammation and manage symptoms, with the choice of therapeutic agents often guided by the specific organ systems involved and the severity of the disease. […] Regular follow-ups are essential to track the course of the disease and the effectiveness of treatment, in addition to pharmacological interventions. […] The chronic and potentially disabling nature of Behets disease also brings pain specialists and mental health professionals to the fore, providing much-needed pain and psychological support. […] Nurses, physical therapists, and patient educators are integral members of the care team, also in keeping a watchful eye on the patients overall status, including any side effects from the medication.

• #4 Relief from Behcet’s Disease Symptoms: Exploring Interventional Pain Treatments | Ortho Sport & Spine Physicians

  https://orthosportandspine.com/blog/relief-from-behcets-disease-symptoms-exploring-interventional-pain-treatments/

  Heat and cold therapy are simple yet effective interventions for managing pain associated with Behcets disease. […] Massage therapy offers a holistic approach to managing pain and discomfort associated with Behcets disease. […] Behcets disease often requires a multidisciplinary approach to pain management. […] Interventional pain treatments offer valuable options for individuals dealing with Behcets disease symptoms. […] A combination of non-surgical methods, including anti-inflammatory medications, steroid/anesthetic injections, physical therapy, heat and cold therapy and massage, can be tailored to address specific pain patterns and improve overall quality of life. […] Consulting with our pain management team at Ortho Sport Spine Physicians can ensure you receive a personalized and comprehensive treatment plan, which is essential for effectively managing Behcets Disease symptoms and enhancing overall well-being.

• #4 Behçet’s Syndrome – Vasculitis Foundation

  https://vasculitisfoundation.org/education/vasculitis-types/behcets-syndrome/

  More severe disease may require immunosuppressive drugs such as methotrexate, azathioprine, cyclosporine, apremilast, and cyclophosphamide. […] Biologics are also an option when Behets is severe. Biologic medications are complex proteins derived from living organisms. They target certain parts of the immune system to control inflammation. Examples used to treat Behets include infliximab, etanercept, adalimumab, and interferon alpha. […] The medications used to treat Behets have potentially serious side effects, such as lowering the body’s ability to fight infection, among others, so it is important to monitor your child’s symptoms and report them to the doctor. Infection prevention is also very important. […] Even with effective treatment and periods of remission, some individuals will experience relapse of Behets—sometimes months or even years after the original symptoms subside. If your initial symptoms return or you develop new ones, report them to your doctor as soon as possible. Regular doctor visits and ongoing monitoring of laboratory and imaging tests are important in detecting relapses early.

• #5 Resources for Behcet’s Patients and Advocates

  https://www.behcets.com/resources

  Once your primary care physician suspects Behcet’s Disease, a rheumatologist should be the next point of contact in order to confirm the diagnosis. […] ABDA partnered with AAIDA for a Behcet’s Education webinar. Featured faculty rheumatologist Delfin Santos, MD, FACR, discusses information of Behcets Disease, describes clinical features, differential diagnosis, management and patient care. […] If you or a loved one has been diagnosed with a rare medical condition such as Behcet’s Disease, having reliable information is critical for making informed health care decisions.

• #5 Behcet Disease Treatment & Management: Approach Considerations, Medical Care, Surgical Care

  https://emedicine.medscape.com/article/329099-treatment

  The goals of therapy in Behet disease are to suppress inflammation and reduce the frequency and severity of recurrences. To be effective, treatment must be started early. The sites and extent of involvement and the severity of disease determine the choice of medication. […] The treatment approach depends on the individual patient, severity of disease, and major organ involvement. […] As disease activity subsides, taper medications to the lowest dose that effectively controls disease activity. Inpatient care is based on individual organ-system involvement. Individualize the transfer situation for each patient based on the specifics of organ-system involvement. […] For oral and genital ulcerations, topical corticosteroids or sucralfate solution are first-line therapy for mild isolated ulcerations.

• #5 Treatment of Behcet’s Disease

  https://www.behcets.com/treatment

  It is likely that a combination of medicines will be used in the treatment of Behcet’s Disease, depending on symptoms. […] Topical medication is applied directly to the ulcers and skin lesions in order to relieve pain and discomfort. […] Most of these drugs have not received FDA approval for the treatment of Behcet’s Disease but may help reduce the symptoms associated with inflammatory diseases. […] Prednisone is used as therapy for gastrointestinal lesions, acute meningoencephalitis, chronic central nervous system lesions, arthritis, erythema nodosum, anterior uveitis and retinal vasculitis. […] Methotrexate is used as therapy for arthritis, retinal vasculitis and chronic central nervous system lesions. […] MAGIC mouthwash is used to alleviate pain in the oral mucosa.

• #5 Behcet Disease Treatment & Management: Approach Considerations, Medical Care, Surgical Care

  https://emedicine.medscape.com/article/329099-treatment

  For severe eye disease (significant drop in visual acuity, retinal vasculitis, or macular involvement), either cyclosporine or infliximab may be used in combination with azathioprine and corticosteroids. […] An expert panel has recommended considering infliximab and adalimumab as first-line immunomodulatory agents for the treatment of ocular manifestations. […] Interferon-alfa, alone or in combination with corticosteroids, can be a second choice in severe ocular Behet disease. […] For gastrointestinal lesions, treatment alternatives based on expert opinion are as follows: Minosalicylate (5-ASA) derivatives (eg, sulfasalazine or mesalamine), systemic corticosteroids, azathioprine, tumor necrosis factor (TNF-) antagonists, thalidomide. […] Arthritis may respond to prednisone, local corticosteroid injections, nonsteroidal anti-inflammatory drugs (NSAIDs), and colchicine.

• #5

  https://www.nhs.uk/conditions/behcets-disease/treatment/

  Daily colchicine tablets can also help by reducing the inflammation in your joints. […] In severe cases where these treatments have not helped, azathioprine or biological therapies may be recommended. […] A number of different medicines may be used to help reduce inflammation of the stomach and bowel caused by Behet’s disease, including corticosteroids, immunosuppressants and biological therapies. […] It’s important to discuss plans to have a baby with your care team, who will be able to adjust your treatment plan to make your pregnancy as safe as possible. […] Corticosteroids can be used to help relieve symptoms of neonatal Behet’s disease. The condition usually resolves within 6 to 8 weeks after the birth.

• #5 Behcet’s syndrome: providing integrated care | JMDH

  https://www.dovepress.com/behcets-syndrome-providing-integrated-care-peer-reviewed-fulltext-article-JMDH

  For joint involvement, colchicine is the first-line treatment choice to prevent arthritis attacks. […] Patients with posterior uveitis with or without retinal vasculitis should be treated with immunosuppressive agents such as azathioprine, cyclosporine, interferon-alpha and anti-TNFs. […] Patients with vascular involvement should be treated with immunosuppressives since they have been shown to reduce relapse rate of venous thrombosis when compared to solo anti-coagulation therapy. […] The conventional treatment modalities for the management of GIBS are glucocorticoids, azathioprine, salazopyrine and other 5-aminosalicylic acid derivatives, similar to inflammatory bowel diseases. […] The treatment of acute NBS includes high-dose intravenous methylprednisolone pulses for 710 days followed by gradual oral tapering over 36 months, depending on the relapse severity. […] Patients are usually seen every 36 months depending on the severity of their diseases. The frequency of mucocutaneous lesions and any new manifestations are recorded in each visit. Eye examination is repeated in every visit in patients presenting with ocular involvement.

• #5 Behcet Disease Treatment & Management: Approach Considerations, Medical Care, Surgical Care

  https://emedicine.medscape.com/article/329099-treatment

  Central nervous system (CNS) disease is usually treated with systemic corticosteroids, interferon-alfa, azathioprine, cyclophosphamide, methotrexate, and TNF- antagonists. […] Treatment of major-vessel disease with thrombotic events is with systemic anticoagulation in addition to corticosteroids, azathioprine, cyclophosphamide, or cyclosporine. […] TNF- antagonists are increasingly used and have become standard treatment of Behet disease that is inadequately controlled by standard immunosuppressive regimens. […] Infliximab has been most widely studied, but adalimumab has proved successful in cases refractory to both conventional therapy and infliximab. […] Surgery may also be considered in the following circumstances: Pulmonary aneurysms and areas that incur ischemic damage due to vasculitis or thrombosis may require resection. […] Activity is suggested as tolerated and may be limited owing to systemic symptoms or arthritis.

• #5

  https://www.nhs.uk/conditions/behcets-disease/treatment/

  There’s currently no cure for Behet’s disease, but a number of treatments can help to relieve symptoms and reduce the risk of serious complications. […] Once a diagnosis of Behet’s disease has been confirmed, you’ll usually be referred to several different specialists who have experience of treating the condition. They’ll help draw up a specific treatment plan for you. […] Your treatment plan usually involves the use of a combination of different medicines. Depending on the type and severity of your symptoms, you may only need to take medicines when you have a flare-up. […] Alternatively, you may have to take medicines on a long-term basis to stop serious complications developing, such as vision loss. […] You may also be offered emotional, employment and welfare support, as well as information about support groups you can join.

• #5 Behcet Syndrome – What You Need to Know

  https://www.drugs.com/cg/behcet-syndrome.html

  Your healthcare provider will examine you and ask about your symptoms. […] Treatment may depend on your symptoms and problems caused by Behcet syndrome. […] You may only need to take medicine during a flare-up. […] You may be given medicine to decrease pain and inflammation. […] Medicine may also be given to prevent your immune system from attacking healthy tissue. […] Rest during a flare-up. […] Apply ice or heat on painful joints. […] Eat soft, bland foods if you have mouth sores. […] Get regular exercise when your symptoms are gone. […] Join a support group. […] You have the right to help plan your care. […] Discuss treatment options with your healthcare providers to decide what care you want to receive.

• #5 Find Help For Behcet’s Disease Patients: Support Groups, Clinical Resource Downloads & More | Behcet’s Connection – Celgene Corporation

  https://www.behcetsconnection.com/access-resources

  The American Behcets Disease Association (ABDA) supports, educates, and empowers the Behets community, while continuously advocating for better research diagnostics, treatment, and a cure. […] The Vasculitis Foundation is a membership-based organization of patients with vasculitis, caregivers, friends, family, physicians, and researchers advocating for early diagnosis, better treatments, and improving quality of life for patients with vasculitis, including Behets Disease. […] One of the main issues in Behets management is that we dont have adequate resources, neither for the patients nor for the doctors. […] Behets is not a hopeless condition and I think theres a lot of reasons for patients to have hope.

• #5 Behcet’s syndrome: providing integrated care | JMDH

  https://www.dovepress.com/behcets-syndrome-providing-integrated-care-peer-reviewed-fulltext-article-JMDH

  Multidisciplinary patient care is essential for the management of BS, as it is for other multisystem diseases. Rheumatologists, dermatologists, ophthalmologists, neurologists, cardiovascular surgeons and gastroenterologists are members of the multidisciplinary team. […] A multidisciplinary team of rheumatologists, dermatologists, ophthalmologists, neurologists, cardiovascular surgeons and gastroenterologists, often led by rheumatologists, take part in the management of patients with BS. […] The treatment should be individualized for each patient. The main principles of treatment are to suppress inflammation quickly during acute attacks in order to prevent damage and to prevent relapses with immunosuppressives if needed. […] The treatment of mucocutaneous lesions depends on the severity of each lesion. For isolated OUs and GUs, topical measures are usually sufficient.

• #5 Relief from Behcet’s Disease Symptoms: Exploring Interventional Pain Treatments | Ortho Sport & Spine Physicians

  https://orthosportandspine.com/blog/relief-from-behcets-disease-symptoms-exploring-interventional-pain-treatments/

  Behcets disease, a chronic condition characterized by inflammation of blood vessels, can lead to various symptoms, including pain and discomfort. Non-surgical methods that we offer at Ortho Sport Spine Physicians can play a crucial role in providing relief and improving the quality of life for individuals dealing with Behcets Disease. The following are treatments we offer to combat the pain associated with Behcets disease. […] Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly prescribed to reduce inflammation and alleviate pain associated with Behcets. […] For more targeted relief, interventional pain treatments include steroid/anesthetic injections. […] Physical therapy plays a crucial role in managing Behcets disease symptoms, focusing on improving flexibility, strength and mobility.

• #5 Behçet’s Syndrome – Vasculitis Foundation

  https://vasculitisfoundation.org/education/vasculitis-types/behcets-syndrome/

  More severe disease may require immunosuppressive drugs such as methotrexate, azathioprine, cyclosporine, apremilast, and cyclophosphamide. […] Biologics are also an option when Behets is severe. Biologic medications are complex proteins derived from living organisms. They target certain parts of the immune system to control inflammation. Examples used to treat Behets include infliximab, etanercept, adalimumab, and interferon alpha. […] The medications used to treat Behets have potentially serious side effects, such as lowering the body’s ability to fight infection, among others, so it is important to monitor your child’s symptoms and report them to the doctor. Infection prevention is also very important. […] Even with effective treatment and periods of remission, some individuals will experience relapse of Behets—sometimes months or even years after the original symptoms subside. If your initial symptoms return or you develop new ones, report them to your doctor as soon as possible. Regular doctor visits and ongoing monitoring of laboratory and imaging tests are important in detecting relapses early.

• #5 Behçet’s Disease, Pathogenesis, Clinical Features, and Treatment Approaches: A Comprehensive Review

  https://pmc.ncbi.nlm.nih.gov/articles/PMC11051811/

  Behets disease is a systemic inflammatory disorder of unknown etiology. […] Diagnosis is primarily clinical due to the lack of a definitive diagnostic test, and management involves a multidisciplinary approach to control inflammation and manage symptoms. […] The management of Behets disease is complex, typically requiring a multidisciplinary approach. […] Treatment strategies primarily aim to control inflammation and manage symptoms, with the choice of therapeutic agents often guided by the specific organ systems involved and the severity of the disease. […] Regular follow-ups are essential to track the course of the disease and the effectiveness of treatment, in addition to pharmacological interventions. […] The chronic and potentially disabling nature of Behets disease also brings pain specialists and mental health professionals to the fore, providing much-needed pain and psychological support. […] Nurses, physical therapists, and patient educators are integral members of the care team, also in keeping a watchful eye on the patients overall status, including any side effects from the medication.

• #6 Behcet’s syndrome: providing integrated care | JMDH

  https://www.dovepress.com/behcets-syndrome-providing-integrated-care-peer-reviewed-fulltext-article-JMDH

  Multidisciplinary patient care is essential for the management of BS, as it is for other multisystem diseases. Rheumatologists, dermatologists, ophthalmologists, neurologists, cardiovascular surgeons and gastroenterologists are members of the multidisciplinary team. […] A multidisciplinary team of rheumatologists, dermatologists, ophthalmologists, neurologists, cardiovascular surgeons and gastroenterologists, often led by rheumatologists, take part in the management of patients with BS. […] The treatment should be individualized for each patient. The main principles of treatment are to suppress inflammation quickly during acute attacks in order to prevent damage and to prevent relapses with immunosuppressives if needed. […] The treatment of mucocutaneous lesions depends on the severity of each lesion. For isolated OUs and GUs, topical measures are usually sufficient.

• #6 Behcet Disease Treatment & Management: Approach Considerations, Medical Care, Surgical Care

  https://emedicine.medscape.com/article/329099-treatment

  Colchicine has also been used to prevent mucocutaneous relapse. […] For severe mucocutaneous lesions, systemic corticosteroids, azathioprine, pentoxifylline, dapsone, interferon-alfa, colchicine, and thalidomide have demonstrated benefit. […] Apremilast is a second-line treatment for oral ulcers associated with Behet disease. […] A study that compared TNF- inhibitors and apremilast for the treatment of refractory oral ulcers showed that both are equally effective. […] Cutaneous disease with erythema nodosum is a special circumstance and may be treated with colchicine or dapsone. […] In patients who have a delayed response, glucocorticoids and other immunosuppressive treatments may be used to prevent the progression to ulceration. […] For ocular disease, azathioprine is widely accepted as the initial agent.

• #6 Behcet Disease Treatment & Management: Approach Considerations, Medical Care, Surgical Care

  https://emedicine.medscape.com/article/329099-treatment

  For severe eye disease (significant drop in visual acuity, retinal vasculitis, or macular involvement), either cyclosporine or infliximab may be used in combination with azathioprine and corticosteroids. […] An expert panel has recommended considering infliximab and adalimumab as first-line immunomodulatory agents for the treatment of ocular manifestations. […] Interferon-alfa, alone or in combination with corticosteroids, can be a second choice in severe ocular Behet disease. […] For gastrointestinal lesions, treatment alternatives based on expert opinion are as follows: Minosalicylate (5-ASA) derivatives (eg, sulfasalazine or mesalamine), systemic corticosteroids, azathioprine, tumor necrosis factor (TNF-) antagonists, thalidomide. […] Arthritis may respond to prednisone, local corticosteroid injections, nonsteroidal anti-inflammatory drugs (NSAIDs), and colchicine.

• #6 Behcet’s syndrome: providing integrated care | JMDH

  https://www.dovepress.com/behcets-syndrome-providing-integrated-care-peer-reviewed-fulltext-article-JMDH

  For joint involvement, colchicine is the first-line treatment choice to prevent arthritis attacks. […] Patients with posterior uveitis with or without retinal vasculitis should be treated with immunosuppressive agents such as azathioprine, cyclosporine, interferon-alpha and anti-TNFs. […] Patients with vascular involvement should be treated with immunosuppressives since they have been shown to reduce relapse rate of venous thrombosis when compared to solo anti-coagulation therapy. […] The conventional treatment modalities for the management of GIBS are glucocorticoids, azathioprine, salazopyrine and other 5-aminosalicylic acid derivatives, similar to inflammatory bowel diseases. […] The treatment of acute NBS includes high-dose intravenous methylprednisolone pulses for 710 days followed by gradual oral tapering over 36 months, depending on the relapse severity. […] Patients are usually seen every 36 months depending on the severity of their diseases. The frequency of mucocutaneous lesions and any new manifestations are recorded in each visit. Eye examination is repeated in every visit in patients presenting with ocular involvement.

• #6 Behcet Disease Treatment & Management: Approach Considerations, Medical Care, Surgical Care

  https://emedicine.medscape.com/article/329099-treatment

  Central nervous system (CNS) disease is usually treated with systemic corticosteroids, interferon-alfa, azathioprine, cyclophosphamide, methotrexate, and TNF- antagonists. […] Treatment of major-vessel disease with thrombotic events is with systemic anticoagulation in addition to corticosteroids, azathioprine, cyclophosphamide, or cyclosporine. […] TNF- antagonists are increasingly used and have become standard treatment of Behet disease that is inadequately controlled by standard immunosuppressive regimens. […] Infliximab has been most widely studied, but adalimumab has proved successful in cases refractory to both conventional therapy and infliximab. […] Surgery may also be considered in the following circumstances: Pulmonary aneurysms and areas that incur ischemic damage due to vasculitis or thrombosis may require resection. […] Activity is suggested as tolerated and may be limited owing to systemic symptoms or arthritis.

• #6 Behçet’s Disease (Causes, Symptoms, and Treatment)

  https://patient.info/doctor/behcets-disease-pro

  Behet’s disease treatment and management The aim of treatment is to prevent long-term damage. The most severe manifestation of Behet’s disease present in the patient usually determines the choice of treatment. Local therapy: Topical corticosteroids (eg, triamcinolone paste) are effective for oral or genital ulcerations if they are applied during the prodromal stage of ulceration when the symptoms are more mild. Systemic manifestations: Lesions resistant to local measures may require systemic treatment. Systemic treatments are usually given for 1-2 years. They may be given longer for those with gastrointestinal involvement. Patients with eye involvement need early and more aggressive treatment, usually with a brief course of corticosteroid with a longer-term immunosuppressant (eg, azathioprine). Patients with CNS involvement require the most aggressive treatment, usually with a corticosteroid plus either azathioprine, cyclophosphamide, or a TNF-alpha inhibitor. Continual use of immunosuppressive medications may be required to suppress disease. Corticosteroids are effective for acute manifestations but there is no evidence of any beneficial effect on disease progression. Biotherapy approaches, including interferon- (IFN-), tumour necrosis factor- (TNF-) antagonists, and other agents that target interleukins and their receptors, have shown promising results in the treatment of patients with refractory Behet’s disease. Mucocutaneous lesions and joint involvement: These may respond to non-steroidal anti-inflammatory drugs, prednisolone, levamisole, colchicine, dapsone, or sulfapyridine and thalidomide. In most patients, arthritis can be managed with colchicine. Local corticosteroid injections may also be used. Immunosuppressive therapy with azathioprine may be effective. Major vessel disease: Vasculitis is treated with immunosuppressive medication. Prevention of acute deep vein thrombosis is by using immunosuppressive agents rather than anticoagulants. If a venous thrombotic event does occur, however, warfarin is usually given. For pulmonary and peripheral arterial aneurysms, immunosuppressants and corticosteroids are usually given.

• #6 Behcet’s Disease: A 32-year-old female with recurrent ocular inflammation.

  https://webeye.ophth.uiowa.edu/eyeforum/cases/195-Behcets.htm

  A discussion with rheumatology was held and it was felt that her best option was implementing Humira (adalimumab) while switching from azathioprine to mycophenolate mofetil, and starting a rapid steroid taper. […] With the addition of adalimumab her ocular inflammation was rapidly controlled. […] The treatment mantra is generally long-term control with systemic immunosuppressives, such as steroid-sparing agents. […] Corticosteroids are initially used to control acute inflammation, but they are a poor long-term option as resistance can develop and side effects may become severe. […] Biologic agents are gaining acceptance in the treatment of BD. Biologic agents are used to inhibit cytokine signaling, such as tumor necrosis factor (TNF)-alpha (infliximab, adalimumab), as well as lymphocyte-targeted therapies, such as anti-CD20 (rituximab).

• #6

  https://www.nhs.uk/conditions/behcets-disease/treatment/

  There’s currently no cure for Behet’s disease, but a number of treatments can help to relieve symptoms and reduce the risk of serious complications. […] Once a diagnosis of Behet’s disease has been confirmed, you’ll usually be referred to several different specialists who have experience of treating the condition. They’ll help draw up a specific treatment plan for you. […] Your treatment plan usually involves the use of a combination of different medicines. Depending on the type and severity of your symptoms, you may only need to take medicines when you have a flare-up. […] Alternatively, you may have to take medicines on a long-term basis to stop serious complications developing, such as vision loss. […] You may also be offered emotional, employment and welfare support, as well as information about support groups you can join.

• #6 Behcet’s Disease: What Dental Hygienists Should Know & Look For – Today’s RDH

  https://www.todaysrdh.com/behcets-disease-what-dental-hygienists-should-know-look-for/

  Behcets disease is an autoimmune disorder which attacks the blood vessels and creates inflammation. […] Behcets disease is not contagious and can be treated. Most popular treatments are medications such as corticosteroids and immunosuppressive medications. Other medications used to treat sight-specific issues are eye drops, ointment for sores, and mouthwash for mouth ulcers. […] Oral manifestations of Behcets disease are mouth ulcers. […] It is important to give patients instructions to avoid high citrus diet intake to lessen the frequency of the sores as much as possible. Mouthwashes containing Colchicine, Xylocaine or Lidocaine, and Benadryl are prescribed or recommended to help temporarily relieve pain. […] Along with medications, this can be a manageable disease and is treatable.

• #6 Behcet’s Disease Recovery & Support | NYU Langone Health

  https://nyulangone.org/conditions/behcets-disease/support

  There is no cure for Behcets disease, but treatments can keep symptoms under control. […] Therapies are most effective when started early and monitored regularly. […] The goal of treatment with medication is to get you into remission. […] If your symptoms are under control with medication and eventually subside, your doctor may slowly take you off the medication, with the goal of stopping treatment when Behets disease enters a remission phase. […] Some people, however, need long-term medication to control the symptoms of Behets disease. […] You can expect to follow up with your rheumatologist on a regular basis to ensure the treatment is working and to manage any side effects of medication, such as fatigue, high blood pressure, and an increased risk of infection. […] Its important for people with severe symptoms to continue seeing a rheumatologist after treatment is completed. […] Your doctor may want to see you annually for several years to monitor your health and to check for any signs of relapse. […] If Behets disease does flare up, the experts at NYU Langone can immediately treat you and help alleviate your symptoms.

• #6 Behçet’s disease: Treatment, lifestyle tips, and causes

  https://www.medicalnewstoday.com/articles/310313

  There is no cure for Behets disease, but some therapies and lifestyle choices can help relieve symptoms. […] Once a person has a diagnosis of Behets disease, a team of health professionals team will make recommendations about treatment options. […] The team may include an oral health specialist, a dermatologist, ophthalmologist and a rheumatologist, among others. […] Patients should discuss treatment options with their healthcare provider. […] For this reason, it is best for any pregnancy to be planned and discussed first with a health provider. […] Any supplements or complementary therapies should first be discussed with a health provider, as these may worsen symptoms or interact with treatment. […] Medication can relieve pain, control symptoms, and it may help reduce the frequency and severity of flares.

• #6

  https://link.springer.com/article/10.1007/s11926-021-01011-z

  To assess current management of Behcets disease (BD). […] Glucocorticoids are still the main agents for remission-induction and azathioprine the first-line conventional IS in maintenance phase to prevent relapses of major organ involvement. […] Although both conventional IS and biologic agents are effectively used to suppress inflammation in BD, there is still an unmet need for clear therapeutic strategies in the management for different manifestations. Further controlled studies with new biologic agents, anticoagulants and the benefit of concomitant IS usage with biologics are needed to optimize the management of BD.

• #6 Behcet’s Disease: What Dental Hygienists Should Know & Look For – Today’s RDH

  https://www.todaysrdh.com/behcets-disease-what-dental-hygienists-should-know-look-for/

  As dental professionals, it is important to keep Behcets disease on our radar and ask questions to patients who seem to have regular bouts of ulcers or sores in the mouth. Keeping an active log in our documentation on how often oral symptoms occur can help pinpoint and possibly lead to a definitive diagnosis. We can also use this opportunity to educate patients on Behcets, give oral hygiene instruction, and recommend patients keep us up to date about this medical issue.

• #6 Relief from Behcet’s Disease Symptoms: Exploring Interventional Pain Treatments | Ortho Sport & Spine Physicians

  https://orthosportandspine.com/blog/relief-from-behcets-disease-symptoms-exploring-interventional-pain-treatments/

  Heat and cold therapy are simple yet effective interventions for managing pain associated with Behcets disease. […] Massage therapy offers a holistic approach to managing pain and discomfort associated with Behcets disease. […] Behcets disease often requires a multidisciplinary approach to pain management. […] Interventional pain treatments offer valuable options for individuals dealing with Behcets disease symptoms. […] A combination of non-surgical methods, including anti-inflammatory medications, steroid/anesthetic injections, physical therapy, heat and cold therapy and massage, can be tailored to address specific pain patterns and improve overall quality of life. […] Consulting with our pain management team at Ortho Sport Spine Physicians can ensure you receive a personalized and comprehensive treatment plan, which is essential for effectively managing Behcets Disease symptoms and enhancing overall well-being.

• #6 Behçet’s disease – Clarewell Clinics

  https://clarewellclinics.co.uk/genital-dermatology/behcets-disease/

  It is important for people with Behcets disease to receive regular eye exams to monitor for any vision changes or complications. […] They should also see a dentist regularly to manage any mouth sores and prevent dental complications. […] We will offer you the appropriate medications to help manage your condition. […] With proper management and care, people with Behcets disease can lead healthy, fulfilling lives.

• #6 Behçet’s Syndrome – Vasculitis Foundation

  https://vasculitisfoundation.org/education/vasculitis-types/behcets-syndrome/

  Living with Behets can be challenging at times. Fatigue, pain, emotional stress, and medication side effects can take a toll on your sense of well-being, affecting relationships, work, and other aspects of your daily life. Sharing your experience with family and friends, connecting with others through a support group, or talking with a mental health professional can help. […] There is no cure for Behets syndrome at this time, but treatment can relieve symptoms and prevent potentially serious complications such as blindness and stroke. Behets can be a chronic disorder with periods of remission and relapse, so most patients need to see a doctor on an ongoing basis.

• #6 Behçet’s Syndrome – Vasculitis Foundation

  https://vasculitisfoundation.org/education/vasculitis-types/behcets-syndrome/

  Effective treatment for Behets may require the coordinated efforts and ongoing care of a team of providers and specialists. In addition to a primary care provider, Behets patients may need to see the following specialists: Rheumatologist (joints, muscles, and immune system), Gynecologist (female reproductive system), Urologist (male reproductive system and urinary system), Dermatologist (skin), Ophthalmologist (eyes), Neurologist (brain and nervous system), Pulmonologist (lungs), Gastroenterologist (digestive system) or others as needed. […] The best way to manage your disease is to actively partner with your health care providers. Get to know the members of your health care team. It may be helpful to keep a health care journal to track medications, symptoms, test results and notes from doctor appointments in one place.

• #7

  https://www.nhs.uk/conditions/behcets-disease/treatment/

  For severe ulcers and lesions that do not respond to other treatments, other immunosuppressant tablets or biological therapies may be recommended. […] Because of the potential risk of vision loss in serious cases, any eye inflammation caused by Behet’s disease should be carefully monitored by an ophthalmologist. […] Treatment for eye problems often involves taking azathioprine and corticosteroid medicines, although corticosteroid eyedrops may also be useful. […] In severe cases where these treatments have not helped, immunosuppressant medicines, such as azathioprine or ciclosporin, may be recommended. […] For people with joint pain caused by Behet’s disease, conventional painkillers such as paracetamol and non-steroidal anti-inflammatory drugs (NSAIDs) may sometimes help relieve the pain.

• #7

  https://www.nhs.uk/conditions/behcets-disease/treatment/

  Daily colchicine tablets can also help by reducing the inflammation in your joints. […] In severe cases where these treatments have not helped, azathioprine or biological therapies may be recommended. […] A number of different medicines may be used to help reduce inflammation of the stomach and bowel caused by Behet’s disease, including corticosteroids, immunosuppressants and biological therapies. […] It’s important to discuss plans to have a baby with your care team, who will be able to adjust your treatment plan to make your pregnancy as safe as possible. […] Corticosteroids can be used to help relieve symptoms of neonatal Behet’s disease. The condition usually resolves within 6 to 8 weeks after the birth.

• #7 Behcet’s Disease: A 32-year-old female with recurrent ocular inflammation.

  https://webeye.ophth.uiowa.edu/eyeforum/cases/195-Behcets.htm

  Expert panel recommendations for ocular manifestations of BD now include treatment with anti-TNF therapy with infliximab or adalimumab. This may be considered as first or second-line corticosteroid-sparing therapy. […] There is no cure for BD. The most prevalent morbidity is ocular disease. […] Even with treatment, up to 75% of patients lose useful vision after a 6-10 year period following the onset of ocular symptoms. […] BD may be fatal, with a mortality rate of up to 6%.

• #7 Behcet Disease Treatment & Management: Approach Considerations, Medical Care, Surgical Care

  https://emedicine.medscape.com/article/329099-treatment

  For severe eye disease (significant drop in visual acuity, retinal vasculitis, or macular involvement), either cyclosporine or infliximab may be used in combination with azathioprine and corticosteroids. […] An expert panel has recommended considering infliximab and adalimumab as first-line immunomodulatory agents for the treatment of ocular manifestations. […] Interferon-alfa, alone or in combination with corticosteroids, can be a second choice in severe ocular Behet disease. […] For gastrointestinal lesions, treatment alternatives based on expert opinion are as follows: Minosalicylate (5-ASA) derivatives (eg, sulfasalazine or mesalamine), systemic corticosteroids, azathioprine, tumor necrosis factor (TNF-) antagonists, thalidomide. […] Arthritis may respond to prednisone, local corticosteroid injections, nonsteroidal anti-inflammatory drugs (NSAIDs), and colchicine.

• #7 Treatment of Behcet’s Disease

  https://www.behcets.com/treatment

  It is likely that a combination of medicines will be used in the treatment of Behcet’s Disease, depending on symptoms. […] Topical medication is applied directly to the ulcers and skin lesions in order to relieve pain and discomfort. […] Most of these drugs have not received FDA approval for the treatment of Behcet’s Disease but may help reduce the symptoms associated with inflammatory diseases. […] Prednisone is used as therapy for gastrointestinal lesions, acute meningoencephalitis, chronic central nervous system lesions, arthritis, erythema nodosum, anterior uveitis and retinal vasculitis. […] Methotrexate is used as therapy for arthritis, retinal vasculitis and chronic central nervous system lesions. […] MAGIC mouthwash is used to alleviate pain in the oral mucosa.

• #7 French recommendations for the management of Behçet’s disease | Orphanet Journal of Rare Diseases | Full Text

  https://ojrd.biomedcentral.com/articles/10.1186/s13023-020-01620-4

  Behets disease is a vascularity of vessels of all calibers that affects the arterial and venous areas. Specialized multi-disciplinary care in an expert center is necessary for this rare disease with very polymorphic expression and requiring extended treatments and lifelong follow-up. The drug treatments for Behets disease essentially depend on the clinical manifestations and target the abatement of inflammation. Colchicine is the first-choice treatment of mucocutaneous and articular involvement. The most serious, ocular, vascular, or neurological involvements require immunomodulating treatment, most often associating systemic corticosteroid therapy with immunosuppressants and biotherapy (anti-TNF), depending on the indication. […] Therapeutic education is indispensable to optimize the care and compliance of the patient with the therapeutic project. The diagnosis of Behets disease is clinical. The pediatric and familial forms may be syndromic (of genetic origin). Severe organ damage (ocular, digestive, neurological, cardiovascular, and pulmonary) requires care by expert centers. A multidisciplinary team is indispensable for the care of Behets disease. […] The use of anticoagulants in treating vascular involvement is disputed but remains recommended; inflammation of the vascular walls is the main cause of Behets disease-related thrombosis.

• #7 Behçet’s Syndrome – Vasculitis Foundation

  https://vasculitisfoundation.org/education/vasculitis-types/behcets-syndrome/

  More severe disease may require immunosuppressive drugs such as methotrexate, azathioprine, cyclosporine, apremilast, and cyclophosphamide. […] Biologics are also an option when Behets is severe. Biologic medications are complex proteins derived from living organisms. They target certain parts of the immune system to control inflammation. Examples used to treat Behets include infliximab, etanercept, adalimumab, and interferon alpha. […] The medications used to treat Behets have potentially serious side effects, such as lowering the body’s ability to fight infection, among others, so it is important to monitor your child’s symptoms and report them to the doctor. Infection prevention is also very important. […] Even with effective treatment and periods of remission, some individuals will experience relapse of Behets—sometimes months or even years after the original symptoms subside. If your initial symptoms return or you develop new ones, report them to your doctor as soon as possible. Regular doctor visits and ongoing monitoring of laboratory and imaging tests are important in detecting relapses early.

• #7 Behçet’s Syndrome – Vasculitis Foundation

  https://vasculitisfoundation.org/education/vasculitis-types/behcets-syndrome/

  Living with Behets can be challenging at times. Fatigue, pain, emotional stress, and medication side effects can take a toll on your sense of well-being, affecting relationships, work, and other aspects of your daily life. Sharing your experience with family and friends, connecting with others through a support group, or talking with a mental health professional can help. […] There is no cure for Behets syndrome at this time, but treatment can relieve symptoms and prevent potentially serious complications such as blindness and stroke. Behets can be a chronic disorder with periods of remission and relapse, so most patients need to see a doctor on an ongoing basis.

• #7 Behcets Disease- Symptoms, Causes and Treatment | Dr. Agarwals

  https://www.dragarwal.com/diseases-conditions/behcets-disease/

  There is no specific cure for this disease. However, when it comes to treatment for behcets disease, it consists of medications to reduce your discomfort, control the Inflammation of your and prevent severe complications. Medications include steroids to suppress the errant immune system, colchicine etc. Steroid eye drops and steroid injections next to your eye may be given. […] It is suggested that you make certain lifestyle changes to control the symptoms. These lifestyle changes include eating a balanced diet, including healthy vegetables and fruits. It is also suggested to avoid containing excess sugar and fat to protect overall gut health. […] Additionally, if mouth ulcers are a symptom you are experiencing, it is suggested that you cut down foods such as pineapple, nuts and lemon that can aggregate the symptoms.

• #7 Red Whale | Behçet’s syndrome

  https://www.redwhale.co.uk/content/behcets-syndrome

  Behçet’s syndrome, also known as Behçet’s disease, is a rare multi-system inflammatory condition. […] In primary care, we can help by being aware of when to suspect and refer, and by having some understanding of the associated risks to watch out for. […] If we suspect Behçet’s, we should refer to secondary care for MDT review and diagnostic assessment. […] At MDT review, the specialist teams should use a disease-specific tool to assess disease activity and quality of life. […] Treatment depends on the manifestation of the disease, but will usually involve potent topical corticosteroids followed by systemic steroids (oral or IM), with disease-modifying steroid-sparing drugs once the condition is stabilised. […] Refer any suspected case to secondary care for diagnosis and management with DMARDs and corticosteroids.

• #7 Interdisciplinary Autoimmune Summit

  https://www.healio.com/news/rheumatology/20200713/behcets-disease-remains-largely-unknown-among-physicians

  The rare and complex Behcets disease is often misdiagnosed or undiagnosed, leading to significant, but unnecessary, morbidity, according to a presenter at the 2020 Interdisciplinary Autoimmune Summit. […] Santos described Behcets disease as a chronic, multisystemic inflammatory disorder that is marked primarily by oral and genital ulcers, along with variable vessel vasculitis meaning that it affects arteries and veins that can bring manifestations to all systems of the body, from the skin to the eyes to neurological centers. […] The oral and genital components of the disease can affect daily living, socializing and other associated quality of life (QOL) parameters. This disease affects your ability to eat and talk, Santos said. Vaginal ulcers can lead to sexual dysfunction. […] In general, individuals with Behcets disease frequently report low self-esteem, negative body image, anxiety, fear and tension, according to Santos. He stressed that the chronic, debilitating nature of the condition makes it imperative that clinicians improve in the entire spectrum from diagnosis to treatment. You have to plan your events around manifestations of this disease, he said.

• #7 Behcet’s Disease Signs & Symptoms | Rush

  https://www.rush.edu/conditions/behcets-disease

  Behcet’s disease is treatable but not curable. Symptoms may disappear (go into remission) and come back (flare). Your Rush rheumatologist will work with you to develop a personalized plan to reduce your pain, and prevent flares and complications. With effective treatment, flares typically become less frequent. […] Your treatment at Rush might include the following medications: Corticosteroids to reduce pain and inflammation, Immunosuppressive medicine to control the immune system, reduce inflammation and prevent flares, Eye drops for inflammation in the eyes, Topical steroids to treat rashes and other skin symptoms. […] Getting a lot of rest when your symptoms are flaring may help. During periods of remission, moderate exercise, such as swimming or walking, can help prevent flares. […] Behcets disease affects several organ systems. Other specialists may be consulted during your diagnosis, including some of the following: Ophthalmologists to identify and treat complications from eye inflammation, Dermatologists to address mouth or skin lesions, Gynecologists to treat womens genital sores, Urologists to treat mens genital sores, Gastroenterologists to identify and manage digestive problems.

• #7 Relief from Behcet’s Disease Symptoms: Exploring Interventional Pain Treatments | Ortho Sport & Spine Physicians

  https://orthosportandspine.com/blog/relief-from-behcets-disease-symptoms-exploring-interventional-pain-treatments/

  Heat and cold therapy are simple yet effective interventions for managing pain associated with Behcets disease. […] Massage therapy offers a holistic approach to managing pain and discomfort associated with Behcets disease. […] Behcets disease often requires a multidisciplinary approach to pain management. […] Interventional pain treatments offer valuable options for individuals dealing with Behcets disease symptoms. […] A combination of non-surgical methods, including anti-inflammatory medications, steroid/anesthetic injections, physical therapy, heat and cold therapy and massage, can be tailored to address specific pain patterns and improve overall quality of life. […] Consulting with our pain management team at Ortho Sport Spine Physicians can ensure you receive a personalized and comprehensive treatment plan, which is essential for effectively managing Behcets Disease symptoms and enhancing overall well-being.

• #7 Behcet’s Disease (+ 6 Natural Ways to Improve Symptoms) – Dr. Axe

  https://draxe.com/health/behcets-disease/

  Behcets disease is known to affect certain organs and tissues including the eyes, mouth, skin, lungs, joints, genitals, brain, and gastrointestinal tract. […] There is no cure for Behcets disease, but conventional Behcets disease treatment aims to relieve specific symptoms. Treatment typically includes topical and oral medications including corticosteroids and other immunosuppressants. […] According to the Mayo Clinic, no cure exists for Behcets disease. If you have a mild form of the condition, your doctor may offer medications to control temporary flares in pain and inflammation. […] Since people with Behcets are prone to mouth sores, it’s very important that they maintain good oral health, which includes regular brushing and flossing. […] Health complications due to Behcets depends upon your individual signs and symptoms of the disease. Anyone with eye symptoms of Behcets disease should see an ophthalmologist on a regular basis since untreated uveitis can result in decreased vision or even blindness.

• #7 Behçet’s Syndrome – Vasculitis Foundation

  https://vasculitisfoundation.org/education/vasculitis-types/behcets-syndrome/

  Effective treatment for Behets may require the coordinated efforts and ongoing care of a team of providers and specialists. In addition to a primary care provider, Behets patients may need to see the following specialists: Rheumatologist (joints, muscles, and immune system), Gynecologist (female reproductive system), Urologist (male reproductive system and urinary system), Dermatologist (skin), Ophthalmologist (eyes), Neurologist (brain and nervous system), Pulmonologist (lungs), Gastroenterologist (digestive system) or others as needed. […] The best way to manage your disease is to actively partner with your health care providers. Get to know the members of your health care team. It may be helpful to keep a health care journal to track medications, symptoms, test results and notes from doctor appointments in one place.

• #8 Behcet’s syndrome: providing integrated care | JMDH

  https://www.dovepress.com/behcets-syndrome-providing-integrated-care-peer-reviewed-fulltext-article-JMDH

  Multidisciplinary patient care is essential for the management of BS, as it is for other multisystem diseases. Rheumatologists, dermatologists, ophthalmologists, neurologists, cardiovascular surgeons and gastroenterologists are members of the multidisciplinary team. […] A multidisciplinary team of rheumatologists, dermatologists, ophthalmologists, neurologists, cardiovascular surgeons and gastroenterologists, often led by rheumatologists, take part in the management of patients with BS. […] The treatment should be individualized for each patient. The main principles of treatment are to suppress inflammation quickly during acute attacks in order to prevent damage and to prevent relapses with immunosuppressives if needed. […] The treatment of mucocutaneous lesions depends on the severity of each lesion. For isolated OUs and GUs, topical measures are usually sufficient.

• #8 Behcet Disease Treatment & Management: Approach Considerations, Medical Care, Surgical Care

  https://emedicine.medscape.com/article/329099-treatment

  Colchicine has also been used to prevent mucocutaneous relapse. […] For severe mucocutaneous lesions, systemic corticosteroids, azathioprine, pentoxifylline, dapsone, interferon-alfa, colchicine, and thalidomide have demonstrated benefit. […] Apremilast is a second-line treatment for oral ulcers associated with Behet disease. […] A study that compared TNF- inhibitors and apremilast for the treatment of refractory oral ulcers showed that both are equally effective. […] Cutaneous disease with erythema nodosum is a special circumstance and may be treated with colchicine or dapsone. […] In patients who have a delayed response, glucocorticoids and other immunosuppressive treatments may be used to prevent the progression to ulceration. […] For ocular disease, azathioprine is widely accepted as the initial agent.

• #8 Behcet Disease Treatment & Management: Approach Considerations, Medical Care, Surgical Care

  https://emedicine.medscape.com/article/329099-treatment

  For severe eye disease (significant drop in visual acuity, retinal vasculitis, or macular involvement), either cyclosporine or infliximab may be used in combination with azathioprine and corticosteroids. […] An expert panel has recommended considering infliximab and adalimumab as first-line immunomodulatory agents for the treatment of ocular manifestations. […] Interferon-alfa, alone or in combination with corticosteroids, can be a second choice in severe ocular Behet disease. […] For gastrointestinal lesions, treatment alternatives based on expert opinion are as follows: Minosalicylate (5-ASA) derivatives (eg, sulfasalazine or mesalamine), systemic corticosteroids, azathioprine, tumor necrosis factor (TNF-) antagonists, thalidomide. […] Arthritis may respond to prednisone, local corticosteroid injections, nonsteroidal anti-inflammatory drugs (NSAIDs), and colchicine.

• #8 Behçet’s Disease (Causes, Symptoms, and Treatment)

  https://patient.info/doctor/behcets-disease-pro

  Behet’s disease treatment and management The aim of treatment is to prevent long-term damage. The most severe manifestation of Behet’s disease present in the patient usually determines the choice of treatment. Local therapy: Topical corticosteroids (eg, triamcinolone paste) are effective for oral or genital ulcerations if they are applied during the prodromal stage of ulceration when the symptoms are more mild. Systemic manifestations: Lesions resistant to local measures may require systemic treatment. Systemic treatments are usually given for 1-2 years. They may be given longer for those with gastrointestinal involvement. Patients with eye involvement need early and more aggressive treatment, usually with a brief course of corticosteroid with a longer-term immunosuppressant (eg, azathioprine). Patients with CNS involvement require the most aggressive treatment, usually with a corticosteroid plus either azathioprine, cyclophosphamide, or a TNF-alpha inhibitor. Continual use of immunosuppressive medications may be required to suppress disease. Corticosteroids are effective for acute manifestations but there is no evidence of any beneficial effect on disease progression. Biotherapy approaches, including interferon- (IFN-), tumour necrosis factor- (TNF-) antagonists, and other agents that target interleukins and their receptors, have shown promising results in the treatment of patients with refractory Behet’s disease. Mucocutaneous lesions and joint involvement: These may respond to non-steroidal anti-inflammatory drugs, prednisolone, levamisole, colchicine, dapsone, or sulfapyridine and thalidomide. In most patients, arthritis can be managed with colchicine. Local corticosteroid injections may also be used. Immunosuppressive therapy with azathioprine may be effective. Major vessel disease: Vasculitis is treated with immunosuppressive medication. Prevention of acute deep vein thrombosis is by using immunosuppressive agents rather than anticoagulants. If a venous thrombotic event does occur, however, warfarin is usually given. For pulmonary and peripheral arterial aneurysms, immunosuppressants and corticosteroids are usually given.

• #8 Behcet Disease Treatment & Management: Approach Considerations, Medical Care, Surgical Care

  https://emedicine.medscape.com/article/329099-treatment

  Central nervous system (CNS) disease is usually treated with systemic corticosteroids, interferon-alfa, azathioprine, cyclophosphamide, methotrexate, and TNF- antagonists. […] Treatment of major-vessel disease with thrombotic events is with systemic anticoagulation in addition to corticosteroids, azathioprine, cyclophosphamide, or cyclosporine. […] TNF- antagonists are increasingly used and have become standard treatment of Behet disease that is inadequately controlled by standard immunosuppressive regimens. […] Infliximab has been most widely studied, but adalimumab has proved successful in cases refractory to both conventional therapy and infliximab. […] Surgery may also be considered in the following circumstances: Pulmonary aneurysms and areas that incur ischemic damage due to vasculitis or thrombosis may require resection. […] Activity is suggested as tolerated and may be limited owing to systemic symptoms or arthritis.

• #8 Behçet’s Disease (Causes, Symptoms, and Treatment)

  https://patient.info/doctor/behcets-disease-pro

  Surgery This may be required for: Gastrointestinal complications – eg, perforation and peritonitis. Aneurysms or ischaemic tissues affected by vasculitis or thrombosis. Ventricular aneurysms and coronary thrombosis. Eye involvement – eg, glaucoma, cataracts or retinal detachment. CNS aneurysms or clots.

• #8 Behçet’s Syndrome – Vasculitis Foundation

  https://vasculitisfoundation.org/education/vasculitis-types/behcets-syndrome/

  Effective treatment for Behets may require the coordinated efforts and ongoing care of a team of providers and specialists. In addition to a primary care provider, Behets patients may need to see the following specialists: Rheumatologist (joints, muscles, and immune system), Gynecologist (female reproductive system), Urologist (male reproductive system and urinary system), Dermatologist (skin), Ophthalmologist (eyes), Neurologist (brain and nervous system), Pulmonologist (lungs), Gastroenterologist (digestive system) or others as needed. […] The best way to manage your disease is to actively partner with your health care providers. Get to know the members of your health care team. It may be helpful to keep a health care journal to track medications, symptoms, test results and notes from doctor appointments in one place.

• #8 Behcets Disease | Arthritis Foundation

  https://www.arthritis.org/diseases/behcets-disease

  Behet’s disease is a rare autoimmune disorder that causes the body’s blood vessels to swell. […] The goal of Behet’s treatment is to reduce pain and prevent complications. Doctors may prescribe medicines such as corticosteroids and immunosuppressive drugs to reduce the underlying inflammation. […] In addition to prescribed treatments, people with Behet’s will benefit from rest during outbreaks of lesions or other symptoms. Moderate exercise, such as swimming or walking, are helpful during symptom-free periods.

• #8 Behcet’s Disease Recovery & Support | NYU Langone Health

  https://nyulangone.org/conditions/behcets-disease/support

  There is no cure for Behcets disease, but treatments can keep symptoms under control. […] Therapies are most effective when started early and monitored regularly. […] The goal of treatment with medication is to get you into remission. […] If your symptoms are under control with medication and eventually subside, your doctor may slowly take you off the medication, with the goal of stopping treatment when Behets disease enters a remission phase. […] Some people, however, need long-term medication to control the symptoms of Behets disease. […] You can expect to follow up with your rheumatologist on a regular basis to ensure the treatment is working and to manage any side effects of medication, such as fatigue, high blood pressure, and an increased risk of infection. […] Its important for people with severe symptoms to continue seeing a rheumatologist after treatment is completed. […] Your doctor may want to see you annually for several years to monitor your health and to check for any signs of relapse. […] If Behets disease does flare up, the experts at NYU Langone can immediately treat you and help alleviate your symptoms.

• #8 Find Help For Behcet’s Disease Patients: Support Groups, Clinical Resource Downloads & More | Behcet’s Connection – Celgene Corporation

  https://www.behcetsconnection.com/access-resources

  The American Behcets Disease Association (ABDA) supports, educates, and empowers the Behets community, while continuously advocating for better research diagnostics, treatment, and a cure. […] The Vasculitis Foundation is a membership-based organization of patients with vasculitis, caregivers, friends, family, physicians, and researchers advocating for early diagnosis, better treatments, and improving quality of life for patients with vasculitis, including Behets Disease. […] One of the main issues in Behets management is that we dont have adequate resources, neither for the patients nor for the doctors. […] Behets is not a hopeless condition and I think theres a lot of reasons for patients to have hope.

• #8 Interdisciplinary Autoimmune Summit

  https://www.healio.com/news/rheumatology/20200713/behcets-disease-remains-largely-unknown-among-physicians

  The rare and complex Behcets disease is often misdiagnosed or undiagnosed, leading to significant, but unnecessary, morbidity, according to a presenter at the 2020 Interdisciplinary Autoimmune Summit. […] Santos described Behcets disease as a chronic, multisystemic inflammatory disorder that is marked primarily by oral and genital ulcers, along with variable vessel vasculitis meaning that it affects arteries and veins that can bring manifestations to all systems of the body, from the skin to the eyes to neurological centers. […] The oral and genital components of the disease can affect daily living, socializing and other associated quality of life (QOL) parameters. This disease affects your ability to eat and talk, Santos said. Vaginal ulcers can lead to sexual dysfunction. […] In general, individuals with Behcets disease frequently report low self-esteem, negative body image, anxiety, fear and tension, according to Santos. He stressed that the chronic, debilitating nature of the condition makes it imperative that clinicians improve in the entire spectrum from diagnosis to treatment. You have to plan your events around manifestations of this disease, he said.

• #8 Relief from Behcet’s Disease Symptoms: Exploring Interventional Pain Treatments | Ortho Sport & Spine Physicians

  https://orthosportandspine.com/blog/relief-from-behcets-disease-symptoms-exploring-interventional-pain-treatments/

  Heat and cold therapy are simple yet effective interventions for managing pain associated with Behcets disease. […] Massage therapy offers a holistic approach to managing pain and discomfort associated with Behcets disease. […] Behcets disease often requires a multidisciplinary approach to pain management. […] Interventional pain treatments offer valuable options for individuals dealing with Behcets disease symptoms. […] A combination of non-surgical methods, including anti-inflammatory medications, steroid/anesthetic injections, physical therapy, heat and cold therapy and massage, can be tailored to address specific pain patterns and improve overall quality of life. […] Consulting with our pain management team at Ortho Sport Spine Physicians can ensure you receive a personalized and comprehensive treatment plan, which is essential for effectively managing Behcets Disease symptoms and enhancing overall well-being.

• #8 May 20: Behcet’s Awareness Day

  https://www.aiarthritis.org/behcet-s-awareness-day

  Behcet’s disease is considered part of a group of rare autoimmune disorders known as vasculitis, in which the immune system attacks healthy blood vessels. […] While there is no cure for Behcet’s disease, several treatment options can help control inflammation and manage symptoms: […] Medications: These may include corticosteroids, immunosuppressants, and biologics to reduce inflammation and regulate immune activity. […] Symptom-specific care: Topical treatments for ulcers, as well as eye drops for uveitis, can provide targeted relief. […] Lifestyle changes: Stress management, a healthy diet, and avoiding known triggers may help reduce flare-ups. […] Ongoing monitoring: Regular check-ups with specialists, such as rheumatologists or ophthalmologists, are crucial for comprehensive care. […] Behcet’s Disease Awareness Day emphasizes the importance of: […] Educating patients and families about available treatments and resources. […] Support networks and advocacy groups to ensure those with Behcets disease feel empowered and understood.

• #9 Behcet Disease Treatment & Management: Approach Considerations, Medical Care, Surgical Care

  https://emedicine.medscape.com/article/329099-treatment

  For severe eye disease (significant drop in visual acuity, retinal vasculitis, or macular involvement), either cyclosporine or infliximab may be used in combination with azathioprine and corticosteroids. […] An expert panel has recommended considering infliximab and adalimumab as first-line immunomodulatory agents for the treatment of ocular manifestations. […] Interferon-alfa, alone or in combination with corticosteroids, can be a second choice in severe ocular Behet disease. […] For gastrointestinal lesions, treatment alternatives based on expert opinion are as follows: Minosalicylate (5-ASA) derivatives (eg, sulfasalazine or mesalamine), systemic corticosteroids, azathioprine, tumor necrosis factor (TNF-) antagonists, thalidomide. […] Arthritis may respond to prednisone, local corticosteroid injections, nonsteroidal anti-inflammatory drugs (NSAIDs), and colchicine.

• #9 Treatment of Behcet’s Disease

  https://www.behcets.com/treatment

  Apremilast (Otezla), an oral selective phosphodiesterase 4 (PDE4) inhibitor, is the first and only approved treatment by the US Food and Drug Administration (FDA) for oral ulcers associated with Behcet’s Disease. […] Treatment of Behcet’s Disease typically focuses on reducing discomfort and preventing serious complications. […] It is important to treat the manifestations of the disease accordingly. […] It will be helpful to have a primary care physician in order to coordinate treatment and monitor care. […] Communication among various physicians is very important in order to achieve optimal care. […] Patients can control symptoms of Behcet’s Disease with proper medication, rest, exercise, and a healthy lifestyle. […] The goal of treatment is to reduce discomfort and prevent serious complications.

• #9

  https://www.nhs.uk/conditions/behcets-disease/treatment/

  For severe ulcers and lesions that do not respond to other treatments, other immunosuppressant tablets or biological therapies may be recommended. […] Because of the potential risk of vision loss in serious cases, any eye inflammation caused by Behet’s disease should be carefully monitored by an ophthalmologist. […] Treatment for eye problems often involves taking azathioprine and corticosteroid medicines, although corticosteroid eyedrops may also be useful. […] In severe cases where these treatments have not helped, immunosuppressant medicines, such as azathioprine or ciclosporin, may be recommended. […] For people with joint pain caused by Behet’s disease, conventional painkillers such as paracetamol and non-steroidal anti-inflammatory drugs (NSAIDs) may sometimes help relieve the pain.

• #9 Behçet’s Disease (Causes, Symptoms, and Treatment)

  https://patient.info/doctor/behcets-disease-pro

  Surgery This may be required for: Gastrointestinal complications – eg, perforation and peritonitis. Aneurysms or ischaemic tissues affected by vasculitis or thrombosis. Ventricular aneurysms and coronary thrombosis. Eye involvement – eg, glaucoma, cataracts or retinal detachment. CNS aneurysms or clots.

• #9 Behcet Disease Treatment & Management: Approach Considerations, Medical Care, Surgical Care

  https://emedicine.medscape.com/article/329099-treatment

  Central nervous system (CNS) disease is usually treated with systemic corticosteroids, interferon-alfa, azathioprine, cyclophosphamide, methotrexate, and TNF- antagonists. […] Treatment of major-vessel disease with thrombotic events is with systemic anticoagulation in addition to corticosteroids, azathioprine, cyclophosphamide, or cyclosporine. […] TNF- antagonists are increasingly used and have become standard treatment of Behet disease that is inadequately controlled by standard immunosuppressive regimens. […] Infliximab has been most widely studied, but adalimumab has proved successful in cases refractory to both conventional therapy and infliximab. […] Surgery may also be considered in the following circumstances: Pulmonary aneurysms and areas that incur ischemic damage due to vasculitis or thrombosis may require resection. […] Activity is suggested as tolerated and may be limited owing to systemic symptoms or arthritis.

• #9 Behçet’s Syndrome – Vasculitis Foundation

  https://vasculitisfoundation.org/education/vasculitis-types/behcets-syndrome/

  More severe disease may require immunosuppressive drugs such as methotrexate, azathioprine, cyclosporine, apremilast, and cyclophosphamide. […] Biologics are also an option when Behets is severe. Biologic medications are complex proteins derived from living organisms. They target certain parts of the immune system to control inflammation. Examples used to treat Behets include infliximab, etanercept, adalimumab, and interferon alpha. […] The medications used to treat Behets have potentially serious side effects, such as lowering the body’s ability to fight infection, among others, so it is important to monitor your child’s symptoms and report them to the doctor. Infection prevention is also very important. […] Even with effective treatment and periods of remission, some individuals will experience relapse of Behets—sometimes months or even years after the original symptoms subside. If your initial symptoms return or you develop new ones, report them to your doctor as soon as possible. Regular doctor visits and ongoing monitoring of laboratory and imaging tests are important in detecting relapses early.

• #9 Behcet Syndrome – What You Need to Know

  https://www.drugs.com/cg/behcet-syndrome.html

  Your healthcare provider will examine you and ask about your symptoms. […] Treatment may depend on your symptoms and problems caused by Behcet syndrome. […] You may only need to take medicine during a flare-up. […] You may be given medicine to decrease pain and inflammation. […] Medicine may also be given to prevent your immune system from attacking healthy tissue. […] Rest during a flare-up. […] Apply ice or heat on painful joints. […] Eat soft, bland foods if you have mouth sores. […] Get regular exercise when your symptoms are gone. […] Join a support group. […] You have the right to help plan your care. […] Discuss treatment options with your healthcare providers to decide what care you want to receive.

• #9 Behcet’s Disease Signs & Symptoms | Rush

  https://www.rush.edu/conditions/behcets-disease

  Behcet’s disease is treatable but not curable. Symptoms may disappear (go into remission) and come back (flare). Your Rush rheumatologist will work with you to develop a personalized plan to reduce your pain, and prevent flares and complications. With effective treatment, flares typically become less frequent. […] Your treatment at Rush might include the following medications: Corticosteroids to reduce pain and inflammation, Immunosuppressive medicine to control the immune system, reduce inflammation and prevent flares, Eye drops for inflammation in the eyes, Topical steroids to treat rashes and other skin symptoms. […] Getting a lot of rest when your symptoms are flaring may help. During periods of remission, moderate exercise, such as swimming or walking, can help prevent flares. […] Behcets disease affects several organ systems. Other specialists may be consulted during your diagnosis, including some of the following: Ophthalmologists to identify and treat complications from eye inflammation, Dermatologists to address mouth or skin lesions, Gynecologists to treat womens genital sores, Urologists to treat mens genital sores, Gastroenterologists to identify and manage digestive problems.

• #9 Behçet’s Disease, Pathogenesis, Clinical Features, and Treatment Approaches: A Comprehensive Review

  https://pmc.ncbi.nlm.nih.gov/articles/PMC11051811/

  Behets disease is a systemic inflammatory disorder of unknown etiology. […] Diagnosis is primarily clinical due to the lack of a definitive diagnostic test, and management involves a multidisciplinary approach to control inflammation and manage symptoms. […] The management of Behets disease is complex, typically requiring a multidisciplinary approach. […] Treatment strategies primarily aim to control inflammation and manage symptoms, with the choice of therapeutic agents often guided by the specific organ systems involved and the severity of the disease. […] Regular follow-ups are essential to track the course of the disease and the effectiveness of treatment, in addition to pharmacological interventions. […] The chronic and potentially disabling nature of Behets disease also brings pain specialists and mental health professionals to the fore, providing much-needed pain and psychological support. […] Nurses, physical therapists, and patient educators are integral members of the care team, also in keeping a watchful eye on the patients overall status, including any side effects from the medication.

• #9 Interdisciplinary Autoimmune Summit

  https://www.healio.com/news/rheumatology/20200713/behcets-disease-remains-largely-unknown-among-physicians

  The rare and complex Behcets disease is often misdiagnosed or undiagnosed, leading to significant, but unnecessary, morbidity, according to a presenter at the 2020 Interdisciplinary Autoimmune Summit. […] Santos described Behcets disease as a chronic, multisystemic inflammatory disorder that is marked primarily by oral and genital ulcers, along with variable vessel vasculitis meaning that it affects arteries and veins that can bring manifestations to all systems of the body, from the skin to the eyes to neurological centers. […] The oral and genital components of the disease can affect daily living, socializing and other associated quality of life (QOL) parameters. This disease affects your ability to eat and talk, Santos said. Vaginal ulcers can lead to sexual dysfunction. […] In general, individuals with Behcets disease frequently report low self-esteem, negative body image, anxiety, fear and tension, according to Santos. He stressed that the chronic, debilitating nature of the condition makes it imperative that clinicians improve in the entire spectrum from diagnosis to treatment. You have to plan your events around manifestations of this disease, he said.

• #10 Behcet’s syndrome: providing integrated care | JMDH

  https://www.dovepress.com/behcets-syndrome-providing-integrated-care-peer-reviewed-fulltext-article-JMDH

  Multidisciplinary patient care is essential for the management of BS, as it is for other multisystem diseases. Rheumatologists, dermatologists, ophthalmologists, neurologists, cardiovascular surgeons and gastroenterologists are members of the multidisciplinary team. […] A multidisciplinary team of rheumatologists, dermatologists, ophthalmologists, neurologists, cardiovascular surgeons and gastroenterologists, often led by rheumatologists, take part in the management of patients with BS. […] The treatment should be individualized for each patient. The main principles of treatment are to suppress inflammation quickly during acute attacks in order to prevent damage and to prevent relapses with immunosuppressives if needed. […] The treatment of mucocutaneous lesions depends on the severity of each lesion. For isolated OUs and GUs, topical measures are usually sufficient.

• #10 Behcet Disease Treatment & Management: Approach Considerations, Medical Care, Surgical Care

  https://emedicine.medscape.com/article/329099-treatment

  Colchicine has also been used to prevent mucocutaneous relapse. […] For severe mucocutaneous lesions, systemic corticosteroids, azathioprine, pentoxifylline, dapsone, interferon-alfa, colchicine, and thalidomide have demonstrated benefit. […] Apremilast is a second-line treatment for oral ulcers associated with Behet disease. […] A study that compared TNF- inhibitors and apremilast for the treatment of refractory oral ulcers showed that both are equally effective. […] Cutaneous disease with erythema nodosum is a special circumstance and may be treated with colchicine or dapsone. […] In patients who have a delayed response, glucocorticoids and other immunosuppressive treatments may be used to prevent the progression to ulceration. […] For ocular disease, azathioprine is widely accepted as the initial agent.

• #10 Behcet’s Disease (+ 6 Natural Ways to Improve Symptoms) – Dr. Axe

  https://draxe.com/health/behcets-disease/

  Behcets disease is known to affect certain organs and tissues including the eyes, mouth, skin, lungs, joints, genitals, brain, and gastrointestinal tract. […] There is no cure for Behcets disease, but conventional Behcets disease treatment aims to relieve specific symptoms. Treatment typically includes topical and oral medications including corticosteroids and other immunosuppressants. […] According to the Mayo Clinic, no cure exists for Behcets disease. If you have a mild form of the condition, your doctor may offer medications to control temporary flares in pain and inflammation. […] Since people with Behcets are prone to mouth sores, it’s very important that they maintain good oral health, which includes regular brushing and flossing. […] Health complications due to Behcets depends upon your individual signs and symptoms of the disease. Anyone with eye symptoms of Behcets disease should see an ophthalmologist on a regular basis since untreated uveitis can result in decreased vision or even blindness.

• #10 Behçet’s Disease (Causes, Symptoms, and Treatment)

  https://patient.info/doctor/behcets-disease-pro

  Behet’s disease treatment and management The aim of treatment is to prevent long-term damage. The most severe manifestation of Behet’s disease present in the patient usually determines the choice of treatment. Local therapy: Topical corticosteroids (eg, triamcinolone paste) are effective for oral or genital ulcerations if they are applied during the prodromal stage of ulceration when the symptoms are more mild. Systemic manifestations: Lesions resistant to local measures may require systemic treatment. Systemic treatments are usually given for 1-2 years. They may be given longer for those with gastrointestinal involvement. Patients with eye involvement need early and more aggressive treatment, usually with a brief course of corticosteroid with a longer-term immunosuppressant (eg, azathioprine). Patients with CNS involvement require the most aggressive treatment, usually with a corticosteroid plus either azathioprine, cyclophosphamide, or a TNF-alpha inhibitor. Continual use of immunosuppressive medications may be required to suppress disease. Corticosteroids are effective for acute manifestations but there is no evidence of any beneficial effect on disease progression. Biotherapy approaches, including interferon- (IFN-), tumour necrosis factor- (TNF-) antagonists, and other agents that target interleukins and their receptors, have shown promising results in the treatment of patients with refractory Behet’s disease. Mucocutaneous lesions and joint involvement: These may respond to non-steroidal anti-inflammatory drugs, prednisolone, levamisole, colchicine, dapsone, or sulfapyridine and thalidomide. In most patients, arthritis can be managed with colchicine. Local corticosteroid injections may also be used. Immunosuppressive therapy with azathioprine may be effective. Major vessel disease: Vasculitis is treated with immunosuppressive medication. Prevention of acute deep vein thrombosis is by using immunosuppressive agents rather than anticoagulants. If a venous thrombotic event does occur, however, warfarin is usually given. For pulmonary and peripheral arterial aneurysms, immunosuppressants and corticosteroids are usually given.

• #10 Behcet’s Disease for Glendale and Milwaukee, WI | Rheumatic Disease Center | Rheumatologists & Rheumatology

  https://www.rheumaticdiseasecenter.com/service/behcets-disease

  Behets disease is a rare vasculitis where inflamed blood vessels cause problems like open sores and mouth ulcers. […] At the Rheumatic Disease Center offices in Milwaukee and Glendale, Wisconsin, the experienced rheumatologists offer specialized treatment to patients with Behets disease. […] They use advanced treatments like immunosuppressants and biological medication to manage your symptoms. […] Behets disease has no cure, but medication can control the symptoms and help you manage flare-ups. Treatments include: Topical steroid creams and gels, Steroid mouth rinses, Anti-inflammatory eyedrops, Colchicine (Mitigare and Colcrys), Oral corticosteroids, Immunosuppressant medication, Biological therapies. […] Rest and take care of yourself during flare-ups. Exercise more between flare-ups. Walking or swimming helps you stay strong, improves your mood, and keeps your joints flexible. […] Call the Rheumatic Disease Center today or book an appointment online if you have Behets disease symptoms.

• #11 Behçet’s Syndrome – Vasculitis Foundation

  https://vasculitisfoundation.org/education/vasculitis-types/behcets-syndrome/

  Effective treatment for Behets may require the coordinated efforts and ongoing care of a team of providers and specialists. In addition to a primary care provider, Behets patients may need to see the following specialists: Rheumatologist (joints, muscles, and immune system), Gynecologist (female reproductive system), Urologist (male reproductive system and urinary system), Dermatologist (skin), Ophthalmologist (eyes), Neurologist (brain and nervous system), Pulmonologist (lungs), Gastroenterologist (digestive system) or others as needed. […] The best way to manage your disease is to actively partner with your health care providers. Get to know the members of your health care team. It may be helpful to keep a health care journal to track medications, symptoms, test results and notes from doctor appointments in one place.

• #11 Behçet’s Syndrome – Vasculitis Foundation

  https://vasculitisfoundation.org/education/vasculitis-types/behcets-syndrome/

  More severe disease may require immunosuppressive drugs such as methotrexate, azathioprine, cyclosporine, apremilast, and cyclophosphamide. […] Biologics are also an option when Behets is severe. Biologic medications are complex proteins derived from living organisms. They target certain parts of the immune system to control inflammation. Examples used to treat Behets include infliximab, etanercept, adalimumab, and interferon alpha. […] The medications used to treat Behets have potentially serious side effects, such as lowering the body’s ability to fight infection, among others, so it is important to monitor your child’s symptoms and report them to the doctor. Infection prevention is also very important. […] Even with effective treatment and periods of remission, some individuals will experience relapse of Behets—sometimes months or even years after the original symptoms subside. If your initial symptoms return or you develop new ones, report them to your doctor as soon as possible. Regular doctor visits and ongoing monitoring of laboratory and imaging tests are important in detecting relapses early.

• #11

  https://www.nhs.uk/conditions/behcets-disease/treatment/

  Daily colchicine tablets can also help by reducing the inflammation in your joints. […] In severe cases where these treatments have not helped, azathioprine or biological therapies may be recommended. […] A number of different medicines may be used to help reduce inflammation of the stomach and bowel caused by Behet’s disease, including corticosteroids, immunosuppressants and biological therapies. […] It’s important to discuss plans to have a baby with your care team, who will be able to adjust your treatment plan to make your pregnancy as safe as possible. […] Corticosteroids can be used to help relieve symptoms of neonatal Behet’s disease. The condition usually resolves within 6 to 8 weeks after the birth.

• #11 Behcet Disease Treatment & Management: Approach Considerations, Medical Care, Surgical Care

  https://emedicine.medscape.com/article/329099-treatment

  For severe eye disease (significant drop in visual acuity, retinal vasculitis, or macular involvement), either cyclosporine or infliximab may be used in combination with azathioprine and corticosteroids. […] An expert panel has recommended considering infliximab and adalimumab as first-line immunomodulatory agents for the treatment of ocular manifestations. […] Interferon-alfa, alone or in combination with corticosteroids, can be a second choice in severe ocular Behet disease. […] For gastrointestinal lesions, treatment alternatives based on expert opinion are as follows: Minosalicylate (5-ASA) derivatives (eg, sulfasalazine or mesalamine), systemic corticosteroids, azathioprine, tumor necrosis factor (TNF-) antagonists, thalidomide. […] Arthritis may respond to prednisone, local corticosteroid injections, nonsteroidal anti-inflammatory drugs (NSAIDs), and colchicine.

• #11 Behcets Disease- Symptoms, Causes and Treatment | Dr. Agarwals

  https://www.dragarwal.com/diseases-conditions/behcets-disease/

  There is no specific cure for this disease. However, when it comes to treatment for behcets disease, it consists of medications to reduce your discomfort, control the Inflammation of your and prevent severe complications. Medications include steroids to suppress the errant immune system, colchicine etc. Steroid eye drops and steroid injections next to your eye may be given. […] It is suggested that you make certain lifestyle changes to control the symptoms. These lifestyle changes include eating a balanced diet, including healthy vegetables and fruits. It is also suggested to avoid containing excess sugar and fat to protect overall gut health. […] Additionally, if mouth ulcers are a symptom you are experiencing, it is suggested that you cut down foods such as pineapple, nuts and lemon that can aggregate the symptoms.

• #12 Behçet’s Disease, Pathogenesis, Clinical Features, and Treatment Approaches: A Comprehensive Review

  https://pmc.ncbi.nlm.nih.gov/articles/PMC11051811/

  Behets disease is a systemic inflammatory disorder of unknown etiology. […] Diagnosis is primarily clinical due to the lack of a definitive diagnostic test, and management involves a multidisciplinary approach to control inflammation and manage symptoms. […] The management of Behets disease is complex, typically requiring a multidisciplinary approach. […] Treatment strategies primarily aim to control inflammation and manage symptoms, with the choice of therapeutic agents often guided by the specific organ systems involved and the severity of the disease. […] Regular follow-ups are essential to track the course of the disease and the effectiveness of treatment, in addition to pharmacological interventions. […] The chronic and potentially disabling nature of Behets disease also brings pain specialists and mental health professionals to the fore, providing much-needed pain and psychological support. […] Nurses, physical therapists, and patient educators are integral members of the care team, also in keeping a watchful eye on the patients overall status, including any side effects from the medication.

• #12 Behçet’s Syndrome – Vasculitis Foundation

  https://vasculitisfoundation.org/education/vasculitis-types/behcets-syndrome/

  Behets syndrome is a form of vasculitis, a family of rare disorders characterized by inflammation of the blood vessels, which can restrict blood flow and damage vital organs and tissues. Treatment is essential in controlling symptoms and preventing serious complications such as blindness and stroke. […] Treatment depends on the severity of disease and organ system involvement. In mild cases, topical glucocorticoids may be applied to affected areas. For more serious disease, medications that suppress the immune system are used. Behets is a chronic disease and relapses are common, thus ongoing medical care is important. […] Treatment for Behets is aimed at reducing inflammation and preventing organ damage. Treatment depends on disease severity, symptoms, and organ involvement. The first line of treatment may include topical glucocorticoids applied directly to the affected area such as skin creams, gels and ointments, eye drops and mouth rinses. Oral glucocorticoids such as prednisone may also be prescribed to reduce inflammation. If topical or oral steroids aren’t effective, your doctor may prescribe other medications to fight inflammation including colchicine, which is commonly used to treat gout.

• #12 Behcet’s Disease: A 32-year-old female with recurrent ocular inflammation.

  https://webeye.ophth.uiowa.edu/eyeforum/cases/195-Behcets.htm

  Expert panel recommendations for ocular manifestations of BD now include treatment with anti-TNF therapy with infliximab or adalimumab. This may be considered as first or second-line corticosteroid-sparing therapy. […] There is no cure for BD. The most prevalent morbidity is ocular disease. […] Even with treatment, up to 75% of patients lose useful vision after a 6-10 year period following the onset of ocular symptoms. […] BD may be fatal, with a mortality rate of up to 6%.

• #12 Behcet’s disease – Gundry Health – A holistic approach to clinical care. – Dr. Steven Gundry

  https://gundryhealth.com/behcets-disease/

  Treatment for Behcets disease is focused on reducing inflammation and preventing complications. […] Working closely with a healthcare provider to develop a treatment plan appropriate for the individuals needs is essential. In some cases, treatment may involve a combination of medications and lifestyle changes include quitting smoking, maintaining a healthy weight, and engaging in regular physical activity. […] Treatment for Behcets disease is focused on reducing inflammation and preventing complications and may include corticosteroids, immunosuppressive medications, biologics, and antibiotics. Most people with Behcets disease are able to lead everyday lives with proper treatment and management.

• #13

  https://www.nhs.uk/conditions/behcets-disease/treatment/

  There’s currently no cure for Behet’s disease, but a number of treatments can help to relieve symptoms and reduce the risk of serious complications. […] Once a diagnosis of Behet’s disease has been confirmed, you’ll usually be referred to several different specialists who have experience of treating the condition. They’ll help draw up a specific treatment plan for you. […] Your treatment plan usually involves the use of a combination of different medicines. Depending on the type and severity of your symptoms, you may only need to take medicines when you have a flare-up. […] Alternatively, you may have to take medicines on a long-term basis to stop serious complications developing, such as vision loss. […] You may also be offered emotional, employment and welfare support, as well as information about support groups you can join.

• #13 Behcet Disease Treatment & Management: Approach Considerations, Medical Care, Surgical Care

  https://emedicine.medscape.com/article/329099-treatment

  Colchicine has also been used to prevent mucocutaneous relapse. […] For severe mucocutaneous lesions, systemic corticosteroids, azathioprine, pentoxifylline, dapsone, interferon-alfa, colchicine, and thalidomide have demonstrated benefit. […] Apremilast is a second-line treatment for oral ulcers associated with Behet disease. […] A study that compared TNF- inhibitors and apremilast for the treatment of refractory oral ulcers showed that both are equally effective. […] Cutaneous disease with erythema nodosum is a special circumstance and may be treated with colchicine or dapsone. […] In patients who have a delayed response, glucocorticoids and other immunosuppressive treatments may be used to prevent the progression to ulceration. […] For ocular disease, azathioprine is widely accepted as the initial agent.

• #13 Behçet’s disease – Clarewell Clinics

  https://clarewellclinics.co.uk/genital-dermatology/behcets-disease/

  It is important for people with Behcets disease to receive regular eye exams to monitor for any vision changes or complications. […] They should also see a dentist regularly to manage any mouth sores and prevent dental complications. […] We will offer you the appropriate medications to help manage your condition. […] With proper management and care, people with Behcets disease can lead healthy, fulfilling lives.

• #14 Behcet’s Disease (+ 6 Natural Ways to Improve Symptoms) – Dr. Axe

  https://draxe.com/health/behcets-disease/

  Behcets disease is known to affect certain organs and tissues including the eyes, mouth, skin, lungs, joints, genitals, brain, and gastrointestinal tract. […] There is no cure for Behcets disease, but conventional Behcets disease treatment aims to relieve specific symptoms. Treatment typically includes topical and oral medications including corticosteroids and other immunosuppressants. […] According to the Mayo Clinic, no cure exists for Behcets disease. If you have a mild form of the condition, your doctor may offer medications to control temporary flares in pain and inflammation. […] Since people with Behcets are prone to mouth sores, it’s very important that they maintain good oral health, which includes regular brushing and flossing. […] Health complications due to Behcets depends upon your individual signs and symptoms of the disease. Anyone with eye symptoms of Behcets disease should see an ophthalmologist on a regular basis since untreated uveitis can result in decreased vision or even blindness.

• #15 Behçet’s disease – Clarewell Clinics

  https://clarewellclinics.co.uk/genital-dermatology/behcets-disease/

  It is important for people with Behcets disease to receive regular eye exams to monitor for any vision changes or complications. […] They should also see a dentist regularly to manage any mouth sores and prevent dental complications. […] We will offer you the appropriate medications to help manage your condition. […] With proper management and care, people with Behcets disease can lead healthy, fulfilling lives.

• #16 Behcet’s Disease Recovery & Support | NYU Langone Health

  https://nyulangone.org/conditions/behcets-disease/support

  There is no cure for Behcets disease, but treatments can keep symptoms under control. […] Therapies are most effective when started early and monitored regularly. […] The goal of treatment with medication is to get you into remission. […] If your symptoms are under control with medication and eventually subside, your doctor may slowly take you off the medication, with the goal of stopping treatment when Behets disease enters a remission phase. […] Some people, however, need long-term medication to control the symptoms of Behets disease. […] You can expect to follow up with your rheumatologist on a regular basis to ensure the treatment is working and to manage any side effects of medication, such as fatigue, high blood pressure, and an increased risk of infection. […] Its important for people with severe symptoms to continue seeing a rheumatologist after treatment is completed. […] Your doctor may want to see you annually for several years to monitor your health and to check for any signs of relapse. […] If Behets disease does flare up, the experts at NYU Langone can immediately treat you and help alleviate your symptoms.

• #17 Behcet’s syndrome: providing integrated care | JMDH

  https://www.dovepress.com/behcets-syndrome-providing-integrated-care-peer-reviewed-fulltext-article-JMDH

  For joint involvement, colchicine is the first-line treatment choice to prevent arthritis attacks. […] Patients with posterior uveitis with or without retinal vasculitis should be treated with immunosuppressive agents such as azathioprine, cyclosporine, interferon-alpha and anti-TNFs. […] Patients with vascular involvement should be treated with immunosuppressives since they have been shown to reduce relapse rate of venous thrombosis when compared to solo anti-coagulation therapy. […] The conventional treatment modalities for the management of GIBS are glucocorticoids, azathioprine, salazopyrine and other 5-aminosalicylic acid derivatives, similar to inflammatory bowel diseases. […] The treatment of acute NBS includes high-dose intravenous methylprednisolone pulses for 710 days followed by gradual oral tapering over 36 months, depending on the relapse severity. […] Patients are usually seen every 36 months depending on the severity of their diseases. The frequency of mucocutaneous lesions and any new manifestations are recorded in each visit. Eye examination is repeated in every visit in patients presenting with ocular involvement.

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