Materiały źródłowe

• #1 Current concepts in the management of cardiogenic shock | RRCC

  https://www.dovepress.com/current-concepts-in-the-management-of-cardiogenic-shock-peer-reviewed-fulltext-article-RRCC

  Cardiogenic shock most commonly results from myocardial infarction and is associated with mortality rates ranging from 40% to 50%. […] Prevention of fatal RV failure requires treatment that will result in rapid restoration of flow through the occluded pulmonary arteries. […] Therapeutic anticoagulation, with subcutaneous low-molecular-weight heparin; intravenous or subcutaneous unfractionated heparin with monitoring; unmonitored weight-based subcutaneous unfractionated heparin; or subcutaneous fondaparinux, should be given to patients with objectively confirmed PE and no contraindications to anticoagulation (class I; level of evidence A). […] Thrombolysis may be contemplated to treat massive pulmonary emboli (class IIa; level of evidence B). […] The combination of heparin and fibrinolysis to treat massive pulmonary embolism results in a significant reduction in recurrent emboli or death compared with heparin alone. […] Emergent surgical or catheter-based embolectomy may be effective for patients with massive or submassive pulmonary emboli and RV dysfunction, when thrombolysis is contraindicated.

• #2 Cardiogenic shock in ACS. Part 1: prediction, presentation and medical therapy | Nature Reviews Cardiology

  https://www.nature.com/articles/nrcardio.2011.194

  Ischemic cardiogenic shock is a complex, self-perpetuating pathological process that frequently causes death irrespective of medical therapy. […] Early definition of coronary anatomy is a pivotal step towards survival. […] Early reperfusion of the occluded artery can limit infarct size, but ischemia-reperfusion injury or the 'no-reflow’ phenomenon can preclude improvement in myocardial contractility. […] Survival depends on early recognition of shock, followed by aggressive targeted treatment of left, right, or biventricular failure. […] The goal is to prevent end-organ dysfunction and severe metabolic derangement by raising mean arterial pressure, which is achieved with inotropes and vasopressors, often at the expense of tachycardia, elevated myocardial oxygen consumption, and extended ischemia.

• #3 Treatment and prognosis of cardiogenic shock complicating acute myocardial infarction – UpToDate

  https://www.uptodate.com/contents/treatment-and-prognosis-of-cardiogenic-shock-complicating-acute-myocardial-infarction

  Cardiogenic shock is a clinical condition of inadequate tissue (end-organ) perfusion due to cardiac dysfunction. […] In patients with acute MI and cardiogenic shock, the goal of management is to restore perfusion. As such, agents that decrease inotropy or may worsen hypotension should be avoided and include beta blockers, angiotensin converting enzyme inhibitors, angiotensin II receptor blockers, sacubitril-valsartan, and mineralocorticoid receptor antagonists. While these agents have benefits in stable patients with MI or in stable patients with left ventricular (LV) systolic dysfunction, these agents are likely to worsen cardiogenic shock. […] Pulmonary artery catheters may be used to guide management of patients with cardiogenic shock, including temporary mechanical circulatory support (tMCS) device selection and deescalation of tMCS devices or vasoactive agents.

• #4 Cardiogenic Shock » Cardiovascular Interventional Associates

  https://www.cardiacmd.com/we-treat/interventional-cardiology/cardiogenic-shock/

  The best way to prevent cardiogenic shock is to make lifestyle changes to keep your heart healthy and your blood pressure in check. […] If you have a heart attack, quick action can help prevent cardiogenic shock. Seek emergency medical help if you think you’re having a heart attack.

• #5 Cardiogenic shock primary prevention – wikidoc

  https://www.wikidoc.org/index.php/Cardiogenic_shock_primary_prevention

  The most common causes of cardiogenic shock remain MI. […] Primary prevention is important to reduce the burden of heart disease. […] Therefore, effective therapy for shock must include a prevention strategy. […] Attending to the definition of primary prevention, namely the group of measures that aim to avoid the development of a disease state (preventive measures) and considering the fact that left ventricular failure following acute MI is the most common cause of cardiogenic shock, these patients should undergo primary prevention of myocardial infarction. […] The ACC/AHA guideline stresses the importance of primary prevention. […] In patients with two or more major risk factors, calculation of a 10-year coronary artery disease risk score is recommended to assess the need for primary prevention.

• #6 Cardiogenic shock: Causes, symptoms, and treatment

  https://www.medicalnewstoday.com/articles/cardiogenic-shock

  There are no guaranteed screening tests for cardiogenic shock. As the leading cause of cardiogenic shock is a heart attack, anyone experiencing the signs of a heart attack should seek emergency medical care immediately. […] Additionally, lowering the risk of heart attack and heart disease may help reduce the likelihood of cardiogenic shock. […] The NHLBI recommend steps that people can take to make their lifestyle more heart-healthy and reduce their risk of heart disease. These include: quitting smoking, if a smoker, or avoiding secondhand smoke; limiting alcohol intake; reaching or maintaining a moderate weight; maintaining healthy blood pressure and cholesterol levels; finding ways to manage stress, such as mindfulness, meditation, or deep breathing; getting regular physical exercise; getting 7-9 hours of sleep each night; limiting certain foods, such as those high in sodium, saturated fats, and sugars. […] There is no guarantee that these factors will prevent every case of cardiogenic shock. Other issues, such as injury or complications from surgery, may lead to the issue. However, controlling dietary and lifestyle factors that affect the heart may reduce the risk as much as possible.

• #7 Cardiogenic Shock Program – Heart | NewYork-Presbyterian

  https://www.nyp.org/heart/heart-failure/cardiogenic-shock-program

  NewYork-Presbyterian’s renowned cardiac care programs provide advanced, evidence-based support for cardiogenic shock. […] The best way to prevent cardiogenic shock is to prevent the development of coronary artery disease and heart attacks. Following a heart healthy lifestyle is especially important to prevention. […] Control blood pressure Make sure your blood pressure is checked regularly and work closely with a physician if your blood pressure is not at your goal. […] Do not smoke Seek help with quitting if you are smoking and need support. […] Keep cholesterol in check Have your cholesterol evaluated by a physician and discuss lifestyle changes or medication treatment if needed. Avoid high cholesterol foods. […] Eat a heart healthy diet Limit high fat and high cholesterol foods and enrich your diet with vegetables and fruits. […] Exercise regularly Consistent aerobic exercise (around 30 minutes per day) can help improve your heart health. In addition, exercise can help lower your blood pressure and improve your cholesterol. […] Limit alcohol intake

• #8 Cardiogenic Shock: Signs, Causes, and Treatments

  https://www.healthline.com/health/cardiogenic-shock

  Preventing the occurrence of its root causes is key to preventing cardiogenic shock. This includes prevention and treatment of: […] Seek immediate medical attention if you’re having any symptoms that may reflect a heart attack. […] If you have a previous history of heart attack, your doctor may prescribe medications that keep the heart strong or help it recover after a heart attack. […] If you have high blood pressure or a history of heart attack, work with your doctor to manage your blood pressure. […] Exercise regularly to manage your weight. […] Eat a healthy diet to help manage your cholesterol levels. […] If you smoke, quit. […] Most importantly, call 911 or visit an emergency room immediately if you experience a heart attack or any of the symptoms associated with cardiogenic shock. […] Doctors can help prevent cardiogenic shock, but only if you get the medical attention you need.

• #9 What Is Cardiogenic Shock?

  https://www.icliniq.com/articles/heart-circulatory-health/cardiogenic-shock

  How Can Cardiogenic Shock Be Prevented? The best investment to make is in your health. A healthy body forever leads to a healthy life. Cardiogenic shock and many more diseases that pose a warning sign to depleting health can be kept at bay by following a healthy and mindful lifestyle. Individuals who are diabetic, hypertensive, or suffer from other clinical conditions must always keep regular consultation with their doctors as a priority. Keeping a check on vital signs, optimum blood levels, enzymes, hormones, and staying updated with medication cycles will ward off risks of developing a cardiogenic shock. On the other hand, maintaining a healthy weight, quitting smoking, reducing intake of salt and high cholesterol foods, cutting back on sugar, and exercising regularly have proven to be beneficial in the fight against cardiovascular diseases that include cardiogenic shock, myocardial infarct as well as heart attacks.

• #10 Cardiogenic Shock: Risk Factors, Causes and Symptoms

  https://my.clevelandclinic.org/health/diseases/17837-cardiogenic-shock

  Several factors can increase your risk of heart disease, which can eventually lead to cardiogenic shock. Risk factors include: […] Because a heart attack usually causes cardiogenic shock, getting immediate treatment for a heart attack is the best way to prevent cardiogenic shock. […] See your healthcare provider to find out your risk of heart disease and take steps to improve your heart health. If you have coronary artery disease, its important to see your provider as recommended and follow all steps in your plan of care (medications, lifestyle changes, etc.).

• #11 Cardiogenic shock Information | Mount Sinai – New York

  https://www.mountsinai.org/health-library/diseases-conditions/cardiogenic-shock

  You may reduce the risk for developing cardiogenic shock by: […] Quickly treating its cause (such as heart attack or heart valve problem) […] Preventing and treating the risk factors for heart disease, such as diabetes, high blood pressure, high cholesterol and triglycerides, or tobacco use.

• #12 Cardiogenic Shock | Heart & Vascular | Loyola Medicine

  https://www.loyolamedicine.org/services/heart-and-vascular/heart-vascular-conditions/cardiogenic-shock

  Cardiogenic shock is a heart condition that results in the bodys loss of blood and oxygen due to the heart functioning poorly, including poor pumping of the blood. […] Heart attack prevention is necessary to avoid cardiogenic shock. Prevention measures include: Regular exercise, A diet low in cholesterol and saturated fat, Avoiding smoke and/or quitting smoking, Limited sugar and alcohol intake. […] Individuals who have experienced a heart attack have a direct risk of cardiogenic shock. In general, individuals with a personal or family history of heart failure or coronary artery disease are at risk of cardiogenic shock. Having diabetes and/or high blood pressure also increases the risk. Individuals with a genetically related risk of coronary artery disease are also at risk of cardiogenic shock.

• #13 Cardiogenic shock secondary prevention – wikidoc

  https://www.wikidoc.org/index.php/Cardiogenic_shock_secondary_prevention

  Exercise/physical activity – with an optimal target of daily physical activity and a minimum of 30 minutes/day, 3 to 4 times per week. […] Lipid management – if TG 200 mg/dL, then goal of LDL-C 100 mg/dL; if TG 200 mg/dL, then goal of non-HDL-C 130 mg/dL […] Weight management – goal BMI of 18.5-24.9 kg/m2 and Waist Perimeter: women – 35 inches, men – 40 inches. […] Blood pressure control – goal 140/90 mm Hg or 130/80 mm Hg if concomitant diabetes or kidney disease. […] Control of diabetes – goal of HbA1c 7%. […] Smoking cessation – goal of complete cessation. […] Antiplatelet therapy […] RAAS inhibition […] Beta-blockage […] Hormone therapy in women […] Warfarin therapy […] Antioxidant intake.

• #13 Cardiogenic shock secondary prevention – wikidoc

  https://www.wikidoc.org/index.php/Cardiogenic_shock_secondary_prevention

  Secondary prevention includes early detection and halting the progression of established but asymptomatic disease. […] Attending to the definition of secondary prevention, namely the methods or techniques used in order to avoid the development of symptoms of an already existent disease, and considering the fact that left ventricular failure following MI is the most common cause of cardiogenic shock, these patients should undergo secondary prevention of myocardial infarction. This is a crucial part of the management of STEMI patients, regardless of their gender. […] As secondary prevention, these patients have the following indications: Education of patient and family members before discharge – particularly about the importance of lifestyle changes and adherence to the selected treatment.

• #14 Cardiogenic Shock – Developments and Treatment Strategies | ECR Journal

  https://www.ecrjournal.com/articles/cardiogenic-shock-developments-and-treatment-strategies?language_content_entity=en

  Cardiogenic shock remains one of the most serious and challenging conditions in cardiology and is responsible for the highest in-hospital mortality associated with ST-elevation myocardial infarction. The only significant treatment strategy that has been shown to reduce its incidence and inherent mortality is emergent coronary revascularisation. Prevention should aim at early recognition of symptoms, appropriate pre-hospital emergency medical care and prompt primary revascularisation. […] Therefore, the main focus on the management of CS has turned to prevention by a strategy of early diagnosis and prompt reperfusion of patients with STEMI. […] The only modifiable risk factor is time to reperfusion, as demonstrated in a trial comparing pre-hospital thrombolysis and primary PCI, where reperfusion therapy performed within the first two hours of symptom onset significantly reduced the incidence of CS.

• #14 Cardiogenic Shock – Developments and Treatment Strategies | ECR Journal

  https://www.ecrjournal.com/articles/cardiogenic-shock-developments-and-treatment-strategies?language_content_entity=en

  Several MI programmes designed to improve compliance with STEMI guidelines for earlier diagnosis and mechanical reperfusion are being implemented in many countries. The programmes will certainly confirm the impact of improved compliance on the decline of CS. […] Better control of risk factors, greater patient compliance with established medical therapies for coronary artery disease and subsequent decrease in MI are the current goals. So are increased patient awareness, early diagnosis and widespread availability of reperfusion therapies for acute MI, coupled with in-hospital medical compliance with the guidelines.

• #15 Cardiogenic Shock Left Ventricular Failure | Cardiogenic Shock Ejection Fraction

  https://www.radcliffecardiology.com/articles/cardiogenic-shock-left-ventricular-dysfunction-complicating-acute-st-elevation-myocardial?language_content_entity=en

  Cardiogenic shock from left ventricular dysfunction complicating an acute ST-elevation myocardial infarction is associated with high mortality. […] To further improve outcomes, earlier pre-emptive and preventive strategies to ensure early revascularization should be pursued. […] Despite the advantages of revascularization, the contemporary mortality rate remains approximately 50% in patients with cardiogenic shock. […] The best approach is prevention of shock, which requires early reperfusion therapy and recognition of lack of reperfusion in patients who receive fibrinolytic therapy.

• #16 Cardiogenic shock

  https://www.openaccessjournals.com/articles/cardiogenic-shock-13122.html

  The basic treatment measures include initial stabilization with volume expansion to obtain euvolaemia, vasopressors, and inotropes plus additional therapy for the prevention or treatment of multiorgan system dysfunction. […] Norepinephrine is associated with fewer arrhythmias and may be the vasopressor of choice in many patients with cardiogenic shock. […] Because catecholamines increase myocardial oxygen consumption and vasoconstrictors may impair microcirculation as well as tissue perfusion, their use should be restricted to the shortest possible duration and the lowest possible dose. […] The ACC/ AHA/SCAI guidelines recommend that in patients presenting with STEMI complicated by cardiogenic shock, emergency revascularization with either PCI or CABG irrespective of the time delay from myocardial infarction onset. […] Despite successful revascularization, mortality in patients with cardiogenic shock remains very high. There has been interest in improved mechanical support devices. These may make revascularization safer.

• #17 Cardiogenic Shock: Causes, Symptoms, Treatment | Doctor

  https://patient.info/doctor/cardiogenic-shock

  Early coronary revascularisation in patients post-MI and adequate treatment of patients with structural heart disease may help to prevent cardiogenic shock. […] Better treatment of acute coronary syndrome seems to be reducing the rates of cardiogenic shock.

• #18 Cardiogenic Shock Treatment & Management: Approach Considerations, Prehospital Care, Resuscitation, Ventilation, and Pharmacologic Intervention

  https://emedicine.medscape.com/article/152191-treatment

  Although cardiogenic shock is not entirely preventable, measures can be taken to minimize the risk of occurrence, recognize it at earlier stages, and begin corrective therapy more expeditiously. Deterrence and prevention require a high degree of suspicion and heightened awareness. […] Care is required in treating patients with acute coronary syndrome who are not yet in cardiogenic shock. Careful use of beta blockers and angiotensin-converting enzyme (ACE) inhibitors in these patients is essential to avoid hypotension leading to cardiogenic shock.

• #19 What Is Cardiogenic Shock? | Carda Health

  https://www.cardahealth.com/post/what-is-cardiogenic-shock

  Absolutely prevention is key. While cardiogenic shock can be unexpected, managing known heart disease risk factors is a proactive step toward prevention. Regular monitoring, adhering to medication regimens, and timely healthcare consultations can reduce potential triggers, ensuring heart health remains a priority. […] Cardiac rehab post-cardiogenic shock offers structured exercise, education, and support, ensuring patients reclaim their health while minimizing the risk of further heart events.

• #20 Prevention and management of critical care complications in cardiogenic shock: a narrative review | Journal of Intensive Care | Full Text

  https://jintensivecare.biomedcentral.com/articles/10.1186/s40560-023-00675-2

  Although mechanical circulatory supports have recently become widely available and used in transforming the management of CS, their routine use to improve outcomes has not been established. […] Therefore, a more comprehensive approach is needed to prevent CS-related complications and improve prognosis. However, more guidance is needed to support the development of the best practices specific to CS. Recent studies have suggested that treatment in high-volume centers, standardized treatment algorithms, dedicated care in cardiovascular intensive care units (CICUs), multidisciplinary therapy, and a systemic approach effectively prevent and treat CS-related complications and improve outcomes. […] In summary, the first step in preventing complications of CS and improving outcomes requires the establishment of a system of care, such as a dedicated closed CICU, a multidisciplinary approach, and treatment in a high-volume center.

• #20 Prevention and management of critical care complications in cardiogenic shock: a narrative review | Journal of Intensive Care | Full Text

  https://jintensivecare.biomedcentral.com/articles/10.1186/s40560-023-00675-2

  Preventing bleeding complications is important in managing CS to ensure optimal patient outcomes. […] Bleeding complications can be prevented by taking appropriate preventive measures. […] In summary, although data among patients with CS are scarce, implementing care bundle strategies to minimize infections has shown positive results in critically ill patients.

• #21 Advocacy and Legislation for Cardiogenic Shock | USC Journal

  https://www.uscjournal.com/articles/advocacy-and-legislation-regionalization-practices-treatment-cardiogenic-shock-time-now

  Cardiogenic shock is a complex hemodynamic state that, despite improvements in care, often remains challenging to treat and confers a high mortality rate. […] To enact this, national and state leaders, as well as federal regulatory bodies, physician thought leaders, industry representatives, and national organizations, must collaborate and advocate for a clear, structured cardiac shock center network with a tiered model for delivery of care for the sickest population of cardiac patients. […] The timely recognition, treatment, and referral of patients with CS remains paramount. […] This concept, known as regionalization of care, involves establishing systems of care whereby higher-volume, specialized facilities receive patients from outlying regional hospitals using clearly defined criteria and established transfer protocols to facilitate the timely triage of a special population of patients.

• #21 Advocacy and Legislation for Cardiogenic Shock | USC Journal

  https://www.uscjournal.com/articles/advocacy-and-legislation-regionalization-practices-treatment-cardiogenic-shock-time-now

  Establishing agreed-upon management strategies, delineating clear criteria for the application of advanced MCS, and acknowledging predefined triggers for consideration of transfer are the cornerstones of regionalization efforts. […] Advocacy Matters: National Leaders and Associations Call for Regionalized Cardiac Shock Centers. […] Altogether, it is evident that thought leaders and national associations alike have achieved a consensus: regionalization of cardiac care for patients with CS represents best-practice care and has the potential to improve outcomes for a patient population that has historically seen unacceptably high mortality rates despite innovation in practice. […] The framework for CS patients is also clear, focusing on timely recognition, appropriate triage, and expeditious transfer to an appropriate level 1 receiving cardiac care center. […] The importance of establishing improved processes to obtain clinically rigorous evidence with the goal of establishing clearly defined best practices for this patient population cannot be understated.

• #22 The Contemporary Cardiogenic Shock ‘Playbook’ | USC Journal

  https://www.uscjournal.com/articles/contemporary-cardiogenic-shock-playbook?language_content_entity=en

  Cardiogenic shock (CS) is a state of end-organ hypoperfusion and dysfunction, often complicated by a systemic inflammatory response, due to insufficient cardiac output despite adequate preload, secondary to left ventricular, right ventricular, or biventricular dysfunction. […] In this special collection of US Cardiology Review, published contemporaneously with the multidisciplinary international SCAI Shock 2021 Virtual conference, a collection of worldwide multispecialty experts address the optimal contemporary playbook for CS prevention, diagnosis, management, and research to include: advocacy and legislative initiatives, drug and device development, diagnostic frameworks and modalities, therapeutic technologies, multidisciplinary systems of care, cardiac intensive care unit management strategies, rescue and replacement innovations, ongoing clinical research efforts, and future outlook for the field.

• #22 The Contemporary Cardiogenic Shock ‘Playbook’ | USC Journal

  https://www.uscjournal.com/articles/contemporary-cardiogenic-shock-playbook?language_content_entity=en

  Five key treatment objectives have been increasingly promoted in the acute management of CS: circulatory support, ventricular support, myocardial perfusion, decongestion, and prevention and management of extracardiac critical illness. […] There is also a parallel need for legislative efforts to develop structured local and regional shock care networks with a tiered model for care delivery for this sickest population of cardiac patients.

• #23 Aligning Treatment Goals and Care Pathways in Cardiogenic Shock

  https://www.acc.org/Latest-in-Cardiology/Articles/2018/10/10/06/39/Aligning-Treatment-Goals-and-Care-Pathways-in-Cardiogenic-Shock

  Despite recent advances and availability of multiple mechanical circulatory-support devices, mortality remains at 50% in patients presenting with acute myocardial infarction complicated by cardiogenic shock (AMICS). […] Fundamental to our goals in cardiogenic shock are standardizing care and aligning level I, level II, and level III emergency centers like trauma care. […] The suggested care pathway establishes minimum standards of care. A strong focus is on training and recognition of cardiogenic shock by emergency medical services to enable patient transfer to a shock care center. […] The National Cardiogenic Shock Initiative (NCSI) is a treatment protocol that has shown improved survival. […] The care pathway summarizes our suggested approach to improve treatment goals: Early emergency medical services recognition of cardiogenic shock, bypassing level II and III centers to transfer patient directly to a level I cardiogenic shock center, hypothermia with targeted temperature management in those who have sustained cardiac arrest with cardiogenic shock but have return of spontaneous circulation, rapid assessment in the emergency room for mechanical complications and appropriateness of left ventricular support and revascularization based on NCSI inclusion and exclusion criteria, placement of an Impella CP percutaneous left ventricular assist device to support the left ventricle prior to percutaneous coronary intervention of the culprit lesion only, with goals of achieving both in 90 minutes, hemodynamic assessment with a right heart cardiac catheterization study after revascularization, escalation and de-escalation of support based on the clinical course of the patient and following CPO and PAPI indices to escalate or de-escalate care.

• #24 Windtree Files Istaroxime Cardiogenic Shock and Prevention of Arrythmias Patent for India – BioSpace

  https://www.biospace.com/press-releases/windtree-files-istaroxime-cardiogenic-shock-and-prevention-of-arrythmias-patent-for-india

  Arrythmias are irregular heartbeats that can impact the pumping function of the heart. Patients with heart failure and cardiomyopathy are at risk for arrythmias. […] As we prepare for Phase 3 readiness in cardiogenic shock, we plan to obtain intellectual property protection in key markets such as India. […] Data from multiple Phase 2 studies in patients with early cardiogenic shock or acute decompensated heart failure have demonstrated that istaroxime infused intravenously significantly improves cardiac function and blood pressure without increasing heart rate or the incidence of cardiac rhythm disturbances. […] Windtree Therapeutics, Inc. is a biotechnology company focused on advancing early and late-stage innovative therapies for critical conditions and diseases. Windtrees portfolio of product candidates includes istaroxime, a Phase 2 candidate with SERCA2a activating properties for acute heart failure and associated cardiogenic shock.

• #25 Windtree Files Istaroxime Cardiogenic Shock and Prevention of Arrythmias Patent for India | Windtree Therapeutics, Inc

  https://ir.windtreetx.com/news-releases/news-release-details/windtree-files-istaroxime-cardiogenic-shock-and-prevention

  Istaroxime and derivatives thereof for preventing or reducing the risk of acute myocardial arrhythmia. […] As we prepare for Phase 3 readiness in cardiogenic shock, we plan to obtain intellectual property protection in key markets such as India. […] Data from multiple Phase 2 studies in patients with early cardiogenic shock or acute decompensated heart failure have demonstrated that istaroxime infused intravenously significantly improves cardiac function and blood pressure without increasing heart rate or the incidence of cardiac rhythm disturbances. […] Windtree’s portfolio of product candidates includes istaroxime, a Phase 2 candidate with SERCA2a activating properties for acute heart failure and associated cardiogenic shock.

• #26 Windtree Files Istaroxime Cardiogenic Shock and Prevention

  https://www.globenewswire.com/news-release/2025/02/27/3033807/0/en/Windtree-Files-Istaroxime-Cardiogenic-Shock-and-Prevention-of-Arrythmias-Patent-for-India.html

  Istaroxime and derivatives thereof for preventing or reducing the risk of acute myocardial arrhythmia. […] Arrythmias are irregular heartbeats that can impact the pumping function of the heart. […] As we prepare for Phase 3 readiness in cardiogenic shock, we plan to obtain intellectual property protection in key markets such as India. […] Data from multiple Phase 2 studies in patients with early cardiogenic shock or acute decompensated heart failure have demonstrated that istaroxime infused intravenously significantly improves cardiac function and blood pressure without increasing heart rate or the incidence of cardiac rhythm disturbances. […] Windtree Therapeutics, Inc. is a biotechnology company focused on advancing early and late-stage innovative therapies for critical conditions and diseases. […] The Company may, in some cases, use terms such as predicts, believes, potential, proposed, continue, estimates, anticipates, expects, plans, intends, may, could, might, will, should or other words that convey uncertainty of future events or outcomes to identify these forward-looking statements.

• #27 What You Need To Know About Cardiogenic Shock | Tufts Medicine

  https://www.tuftsmedicine.org/about-us/news/what-you-need-know-about-cardiogenic-shock

  Cardiogenic shock is scary and can be life-threatening. Heart attacks are the most common cause of cardiogenic shock, so it’s important to seek emergency treatment if you think you are having a heart attack. If you have heart disease or other risk factors related to cardiogenic shock, your doctor will talk to you about ways to prevent a heart attack and lifestyle changes to keep your heart healthy. Your doctor may also recommend medications or devices that keep blood moving from your heart to the rest of your body, tissues and organs. […] Cardiogenic shock poses a high risk of death, the good news is that there is extensive research being conducted into how best to treat cardiogenic shock.

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