Rak piersi u mężczyzn
Diagnostyka i diagnoza
Rak piersi u mężczyzn stanowi mniej niż 1% wszystkich przypadków raka piersi, jednak wymaga równie skrupulatnej diagnostyki jak u kobiet. Diagnostyka rozpoczyna się od szczegółowego wywiadu medycznego i rodzinnego oraz badania fizykalnego piersi i węzłów chłonnych. Badania obrazowe obejmują mammografię o czułości 92-95% i swoistości 90-95%, ultrasonografię oraz rezonans magnetyczny (MRI), który cechuje się najwyższą czułością w wykrywaniu zmian. Biopsja gruboigłowa pod kontrolą USG jest preferowaną metodą potwierdzenia diagnozy. Ocena zaawansowania choroby opiera się na badaniach krwi, RTG klatki piersiowej, tomografii komputerowej, scyntygrafii kości oraz PET. Klasyfikacja nowotworu uwzględnia typ histologiczny (najczęściej rak przewodowy naciekający 85-90%), stopień zróżnicowania, status receptorowy (około 80% hormonozależnych, 15% HER2 dodatnich, 4% potrójnie ujemnych) oraz system TNM, który determinuje stadium zaawansowania (I-IV). W diagnostyce genetycznej istotne jest badanie mutacji BRCA1/2, szczególnie BRCA2, co ma wpływ na leczenie i profilaktykę rodzinną.
- Rak piersi u mężczyzn – Diagnostyka
- Badanie kliniczne i wywiad medyczny
- Badania obrazowe
- Biopsja – złoty standard diagnostyczny
- Ocena węzłów chłonnych
- Badania dodatkowe po diagnozie
- Klasyfikacja raka piersi u mężczyzn
- Genetyczne aspekty diagnostyki
- Wyzwania diagnostyczne w raku piersi u mężczyzn
- Podsumowanie podejścia diagnostycznego
Rak piersi u mężczyzn – Diagnostyka
Rak piersi u mężczyzn jest rzadką chorobą, stanowiącą mniej niż 1% wszystkich przypadków raka piersi. Pomimo rzadkości występowania, choroba ta wymaga dokładnej diagnostyki, podobnie jak w przypadku kobiet. Ze względu na brak świadomości i rutynowych badań przesiewowych, rak piersi u mężczyzn jest często diagnozowany w późniejszym stadium zaawansowania, co może wpływać na gorsze rokowanie12.
Badanie kliniczne i wywiad medyczny
Diagnostyka raka piersi u mężczyzn rozpoczyna się od dokładnego wywiadu medycznego i rodzinnego. Lekarz zbiera informacje na temat objawów, potencjalnych czynników ryzyka oraz historii chorób w rodzinie. Jest to kluczowy etap, który może dostarczyć wskazówek dotyczących przyczyny objawów oraz ocenić, czy pacjent znajduje się w grupie zwiększonego ryzyka zachorowania na raka piersi34.
Następnie przeprowadzane jest dokładne badanie piersi, w trakcie którego lekarz poszukuje guzków lub podejrzanych obszarów oraz ocenia ich teksturę, rozmiar i stosunek do skóry i mięśni. Badanie obejmuje także ocenę węzłów chłonnych pod pachą i nad obojczykiem oraz analizę innych potencjalnych objawów, takich jak wydzielina z brodawki sutkowej czy zmiany skórne56.
Badania obrazowe
Jeśli na podstawie badania klinicznego istnieje podejrzenie raka piersi, lekarz może zalecić przeprowadzenie jednego lub kilku badań obrazowych7:
Mammografia
Mammografia to badanie rentgenowskie piersi, które pozwala lekarzom radiologom obserwować zmiany w tkance piersiowej. W przypadku mężczyzn z objawami sugerującymi raka piersi wykonuje się mammografię diagnostyczną. Badanie to ma wysoką czułość (92-95%) i swoistość (90-95%) w wykrywaniu raka piersi u mężczyzn89.
W badaniu mammograficznym raka piersi u mężczyzn najczęściej obserwuje się niezwapniałą masę (69%), masę z mikrozwapnieniami (29%) lub mikrozwapnienia bez masy (2%). Rak piersi u mężczyzn zazwyczaj występuje w lokalizacji podsutkowej, z zajęciem brodawki w 40-50% przypadków10.
Ultrasonografia
Badanie ultrasonograficzne piersi jest często wykorzystywane do oceny zmian w piersi wykrytych podczas mammografii lub badania fizykalnego. Jest to bezbolesne badanie wykorzystujące fale dźwiękowe do tworzenia obrazu tkanek piersi. USG pomaga określić, czy guz piersi jest lity, czy wypełniony płynem (torbiel), co może pomóc w różnicowaniu między zmianami łagodnymi a potencjalnie złośliwymi1112.
W badaniu ultrasonograficznym rak piersi u mężczyzn zwykle pojawia się jako hipoechogeniczne zmiany z kątowymi, mikropłatowymi lub spikularmi brzegami. USG może również być wykorzystywane do oceny, czy węzły chłonne pod pachą są powiększone, co może wskazywać na rozprzestrzenianie się nowotworu1314.
Rezonans magnetyczny (MRI)
W niektórych przypadkach może być zalecane wykonanie badania rezonansu magnetycznego piersi. MRI wykazuje najwyższą czułość w wykrywaniu raka piersi u mężczyzn w porównaniu z USG i mammografią. Badanie to jest szczególnie przydatne w ocenie rozległości guza i określeniu, czy doszło do inwazji ściany klatki piersiowej1516.
Biopsja – złoty standard diagnostyczny
Biopsja jest jedynym pewnym sposobem na zdiagnozowanie raka piersi. Jest to procedura, podczas której pobiera się próbkę tkanki z podejrzanego obszaru, a następnie bada się ją pod mikroskopem w celu potwierdzenia obecności komórek nowotworowych1718.
Istnieje kilka rodzajów biopsji stosowanych w diagnostyce raka piersi u mężczyzn:
- Biopsja cienkoigłowa (FNA) – pobiera się próbkę komórek za pomocą cienkiej igły. Jest to najłatwiejszy rodzaj biopsji, ale może czasami pominąć komórki rakowe, jeśli igła nie trafi w nie bezpośrednio19.
- Biopsja gruboigłowa (CNB) – najczęściej stosowany rodzaj biopsji w diagnostyce raka piersi. Pozwala na pobranie większej próbki tkanki niż biopsja cienkoigłowa, co zwiększa dokładność diagnozy2021.
- Biopsja chirurgiczna – może być wykonana, jeśli inne procedury biopsyjne nie dają jednoznacznej diagnozy. Podczas biopsji chirurgicznej podejrzana tkanka piersi jest usuwana w całości lub pobierany jest reprezentatywny fragment do analizy22.
Biopsja gruboigłowa pod kontrolą USG daje najbardziej definitywną diagnozę raka piersi u mężczyzn i jest preferowana w stosunku do biopsji cienkoigłowej23.
Ocena węzłów chłonnych
W ramach diagnostyki raka piersi u mężczyzn ważna jest również ocena węzłów chłonnych, szczególnie w dole pachowym. Komórki rakowe mogą oderwać się od guza i rozprzestrzenić się przez układ limfatyczny do węzłów chłonnych2425.
Jeśli węzły chłonne są powiększone, może być wykonana biopsja w celu sprawdzenia, czy zawierają komórki nowotworowe. Biopsja węzła wartowniczego to procedura, w której usuwa się i bada pierwszy węzeł chłonny, do którego najprawdopodobniej rozprzestrzeniłby się nowotwór26.
Badania dodatkowe po diagnozie
Po postawieniu diagnozy raka piersi u mężczyzny, wykonuje się dodatkowe badania w celu oceny stopnia zaawansowania nowotworu i planowania leczenia. Mogą one obejmować2728:
- Badania krwi
- RTG klatki piersiowej
- Tomografię komputerową (CT)
- Scyntygrafię kości
- Pozytonową tomografię emisyjną (PET)
Wyniki tych badań pomagają określić, czy rak rozprzestrzenił się poza pierś i węzły chłonne pachowe, co jest kluczowe dla wyboru odpowiedniej metody leczenia29.
Klasyfikacja raka piersi u mężczyzn
Typy histologiczne
Rak piersi u mężczyzn jest klasyfikowany na podstawie typu komórek, z których się wywodzi. Najczęstszym typem jest rak przewodowy naciekający (inwazyjny), stanowiący 85-90% wszystkich przypadków raka piersi u mężczyzn. Inne, rzadziej występujące typy to rak przewodowy in situ (DCIS), rak zapalny piersi oraz choroba Pageta brodawki sutkowej3031.
Warto zauważyć, że rak zrazikowy jest niezwykle rzadki u mężczyzn, ponieważ w normalnej tkance piersi mężczyzn nie występują zraziki i pęcherzyki32.
Status receptorowy
Badanie statusu receptorowego jest istotną częścią diagnozy raka piersi u mężczyzn. Komórki nowotworowe są badane pod kątem obecności receptorów hormonalnych (estrogenowych i progesteronowych) oraz nadekspresji receptora HER233.
Większość przypadków raka piersi u mężczyzn (około 80%) jest hormonozależna, czyli posiada receptory estrogenowe i/lub progesteronowe. Około 15% wykazuje nadekspresję receptora HER2, a 4% to tzw. raki potrójnie ujemne (bez receptorów estrogenowych, progesteronowych i HER2)3435.
Znajomość statusu receptorowego jest kluczowa dla wyboru odpowiedniej metody leczenia. Na przykład, raki z dodatnimi receptorami hormonalnymi mogą być leczone terapią hormonalną, taką jak tamoksyfen36.
Stopień zróżnicowania (grading)
Komórkom rakowym przypisuje się stopień zróżnicowania (grade) na podstawie tego, jak bardzo przypominają one normalne komórki piersi. Stopień ten jest używany do przewidywania rokowania i pomocy w ustaleniu, które metody leczenia mogą być najbardziej skuteczne37.
Stopień zaawansowania (staging)
Rak piersi u mężczyzn jest klasyfikowany według systemu TNM (Tumor-Nodes-Metastasis), który uwzględnia3839:
- T – rozmiar guza pierwotnego
- N – zajęcie węzłów chłonnych
- M – obecność przerzutów odległych
Na podstawie systemu TNM określa się stadium zaawansowania nowotworu (I-IV), co ma kluczowe znaczenie dla rokowania i wyboru strategii leczenia. Niestety, ze względu na często opóźnioną diagnozę raka piersi u mężczyzn, około 40% wszystkich przypadków w momencie rozpoznania jest w stadium III lub IV40.
Genetyczne aspekty diagnostyki
Badania genetyczne odgrywają istotną rolę w diagnostyce raka piersi u mężczyzn. Osoby z mutacjami genów BRCA1 i BRCA2, szczególnie BRCA2, mają zwiększone ryzyko zachorowania na raka piersi4142.
Krajowa Kompleksowa Sieć Onkologiczna (NCCN) zaleca, aby wszyscy mężczyźni z diagnozą raka piersi przeszli badania genetyczne pod kątem mutacji genów BRCA1/2. Wyniki tych badań mogą mieć wpływ na decyzje dotyczące leczenia oraz identyfikację innych członków rodziny, którzy mogą być narażeni na zwiększone ryzyko43.
Wyzwania diagnostyczne w raku piersi u mężczyzn
Późne rozpoznanie
Jednym z głównych wyzwań w diagnostyce raka piersi u mężczyzn jest późne rozpoznanie choroby. Badania wykazały, że mężczyźni czekali średnio dziesięć miesięcy po pojawieniu się objawów, zanim skonsultowali się z lekarzem. Przyczynia się to do faktu, że rak piersi u mężczyzn jest często diagnozowany w bardziej zaawansowanym stadium niż u kobiet4445.
Czynniki wpływające na opóźnioną diagnozę obejmują4647:
- Brak świadomości o możliwości wystąpienia raka piersi u mężczyzn
- Zwlekanie z szukaniem pomocy medycznej
- Poczucie wstydu związane ze zmianami fizycznymi w okolicy piersi
- Brak rutynowych badań przesiewowych dla mężczyzn
Stygmatyzacja
Stygmatyzacja związana z rakiem piersi u mężczyzn może stanowić barierę w dostępie do opieki zdrowotnej. Badania pokazują, że wielu mężczyzn odczuwa zakłopotanie podczas prezentacji objawów (64,2%) oraz podczas wizyt w klinice piersi (67,8%). Uczucia te są często przypisywane izolacji w klinice i ośrodkach leczenia, gdzie występuje większa liczba pacjentek z rakiem piersi48.
Brak jasnych wytycznych
Brak jasnych wytycznych dotyczących badań przesiewowych w kierunku raka piersi u mężczyzn przyczynia się do późniejszego rozpoznania choroby. W przeciwieństwie do kobiet, dla których zaleca się regularne mammografie po 40. roku życia, nie ma rutynowych zaleceń dotyczących badań przesiewowych dla mężczyzn4950.
NCCN zaleca, aby mężczyźni z mutacjami BRCA przeszli szkolenie w zakresie samobadania piersi i rozpoczęli coroczne kliniczne badania piersi od 35. roku życia. Jednak obecnie nie zaleca się rutynowego wykonywania mammografii ani badań MRI u mężczyzn, nawet nosicieli mutacji BRCA51.
Podsumowanie podejścia diagnostycznego
Diagnostyka raka piersi u mężczyzn obejmuje kompleksowe podejście, podobnie jak w przypadku kobiet. Kluczowe elementy to52:
- Dokładna ocena kliniczna, w tym wywiad medyczny i rodzinny oraz badanie fizykalne piersi
- Badania obrazowe: mammografia i ultrasonografia
- Biopsja (najczęściej gruboigłowa) w celu potwierdzenia diagnozy
- Określenie typu histologicznego, stopnia zróżnicowania i statusu receptorowego nowotworu
- Ocena zaawansowania choroby za pomocą dodatkowych badań obrazowych
- W niektórych przypadkach badania genetyczne pod kątem mutacji BRCA1/2
Wczesne rozpoznanie raka piersi u mężczyzn jest kluczowe dla skutecznego leczenia i poprawy rokowania. Dlatego tak ważne jest zwiększanie świadomości na temat tej choroby zarówno wśród pacjentów, jak i pracowników ochrony zdrowia5354.
Znaczenie wczesnej diagnostyki
Rokowanie dla mężczyzn z rakiem piersi jest podobne do rokowania u kobiet w tym samym wieku i stadium zaawansowania choroby. Jednakże, mężczyźni są często diagnozowani na późniejszym etapie niż kobiety, co może prowadzić do gorszych wyników leczenia55.
W przypadku wykrycia raka we wczesnym stadium zlokalizowanym, 5-letni względny wskaźnik przeżycia wynosi 95%. Dla stadium regionalnego (z zajęciem węzłów chłonnych) spada do 84%, a dla stadium z przerzutami odległymi – do zaledwie 20%56.
Dlatego tak istotne jest, aby mężczyźni byli świadomi możliwości wystąpienia raka piersi i zgłaszali się do lekarza przy jakichkolwiek niepokojących zmianach w okolicy piersi. Wczesna diagnostyka znacząco poprawia szanse na skuteczne leczenie i przeżycie57.
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Materiały źródłowe
- #1 Male Breast Cancer – StatPearls – NCBI Bookshelfhttps://www.ncbi.nlm.nih.gov/books/NBK526036/
Although breast cancer is typically synonymous as a disease that commonly occurs in women, it does occur in men as well. This is because although minimal in quantity, men do have breast tissue that has the potential to become malignant similarly to women, albeit much less commonly. While male breast cancer (MBC) is rare, only occurring in 1% of all breast cancers, it does occur, and it is important to be cognizant of its reality and potential. This activity examines when this condition should be considered in the differential diagnosis and how to evaluate it properly. This activity highlights the role of the interprofessional team in caring for patients with this condition. […] In the United States (US), there are about 2800 cases of male breast cancer annually. Unfortunately, men with breast cancer are often diagnosed late and have high mortality. However, stage for stage, the survival between men and women is similar.
- #2 Male Breast Cancer: Imaging Considerations for Diagnosis and Surveillancehttps://pmc.ncbi.nlm.nih.gov/articles/PMC11161189/
Male breast cancer accounts for less than 1% of all breast cancer cases. […] Despite its rarity, numerous studies have investigated the data on imaging considerations (mammogram, ultrasound, and magnetic resonance imaging (MRI)), but have addressed only certain aspects of male breast cancer. […] The purpose of this review article was to provide a comprehensive overview of the imaging findings, optimal timing to obtain imaging, and the appropriate follow-up strategies in male breast cancer survivors. […] Male breast cancer poses diagnostic imaging challenges as benign breast conditions like gynecomastia must be differentiated from breast cancer. […] The sensitivity and specificity of mammogram in detecting male breast cancer is about 92-95% and 90-95%, respectively. […] The guidelines do not recommend screening mammography or MRI in male BRCA mutation carriers.
- #3 Tests to Help Diagnose Breast Cancer in Men | American Cancer Societyhttps://www.cancer.org/cancer/types/breast-cancer-in-men/detection-diagnosis-staging/how-diagnosed.html
If there is a chance you have breast cancer, your doctor will want to get a complete personal and family medical history. This may give some clues about the cause of any symptoms you are having and if you might be at increased risk for breast cancer. […] A complete breast exam will be done to find any lumps or suspicious areas and to feel their texture, size, and relationship to the skin and muscle. […] If you have signs or symptoms that could mean breast cancer or another breast disease, your doctor might recommend one or more or the following imaging tests. […] A mammogram is a low dose x-ray exam of the breast that allows doctors called radiologists to look for changes in breast tissue. […] It is called a diagnostic mammogram when it is done because problems are present. […] The results of this test might suggest that a biopsy is needed to tell if the abnormal area is cancer.
- #4 Breast Cancer in Men > Fact Sheets > Yale Medicinehttps://www.yalemedicine.org/conditions/male-breast-cancer
Men may not realize that, for them too, any changes in their breasts, including lumps in the chest or underarm area or changes to the nipple could be a sign of breast cancer and should be checked out by a doctor. […] Since men are usually less familiar with its signs and symptoms and because many are unaware that they can be affected by it, their breast cancer is often not diagnosed until it’s in a later, more advanced stage. […] Your doctor will begin to make a diagnosis by asking about your symptoms, whether you have taken or are currently taking certain medications associated with breast cancer, and whether you have any other known risk factors. A breast exam is also an important part of diagnosis. Your doctor will visually examine and feel your chest/breasts for signs of breast cancer.
- #5 Tests to Help Diagnose Breast Cancer in Men | American Cancer Societyhttps://www.cancer.org/cancer/types/breast-cancer-in-men/detection-diagnosis-staging/how-diagnosed.html
If there is a chance you have breast cancer, your doctor will want to get a complete personal and family medical history. This may give some clues about the cause of any symptoms you are having and if you might be at increased risk for breast cancer. […] A complete breast exam will be done to find any lumps or suspicious areas and to feel their texture, size, and relationship to the skin and muscle. […] If you have signs or symptoms that could mean breast cancer or another breast disease, your doctor might recommend one or more or the following imaging tests. […] A mammogram is a low dose x-ray exam of the breast that allows doctors called radiologists to look for changes in breast tissue. […] It is called a diagnostic mammogram when it is done because problems are present. […] The results of this test might suggest that a biopsy is needed to tell if the abnormal area is cancer.
- #6 Breast cancer in men | Canadian Cancer Societyhttps://cancer.ca/en/cancer-information/cancer-types/breast/what-is-breast-cancer/breast-cancer-in-men
During a physical exam, your doctor may do a clinical breast exam to check for lumps in the breast and lymph nodes, hardening or thickening of the breast tissue and changes to the skin or nipple. […] Diagnostic mammography is an x-ray that uses small doses of radiation to make an image of the breast. It is used to follow up on abnormal results of a clinical breast exam. […] An ultrasound uses high-frequency sound waves to make images of parts of the body. It is used to find out if a breast lump is a solid tumour or a cyst. […] During a biopsy, the doctor removes tissues or cells from the body so they can be tested in a lab. A report from the pathologist will confirm whether or not cancer cells are present in the sample. […] A breast biopsy is the only definite way to diagnose breast cancer.
- #7 Tests to Help Diagnose Breast Cancer in Men | American Cancer Societyhttps://www.cancer.org/cancer/types/breast-cancer-in-men/detection-diagnosis-staging/how-diagnosed.html
If there is a chance you have breast cancer, your doctor will want to get a complete personal and family medical history. This may give some clues about the cause of any symptoms you are having and if you might be at increased risk for breast cancer. […] A complete breast exam will be done to find any lumps or suspicious areas and to feel their texture, size, and relationship to the skin and muscle. […] If you have signs or symptoms that could mean breast cancer or another breast disease, your doctor might recommend one or more or the following imaging tests. […] A mammogram is a low dose x-ray exam of the breast that allows doctors called radiologists to look for changes in breast tissue. […] It is called a diagnostic mammogram when it is done because problems are present. […] The results of this test might suggest that a biopsy is needed to tell if the abnormal area is cancer.
- #8 Male Breast Cancer: Imaging Considerations for Diagnosis and Surveillancehttps://pmc.ncbi.nlm.nih.gov/articles/PMC11161189/
Male breast cancer accounts for less than 1% of all breast cancer cases. […] Despite its rarity, numerous studies have investigated the data on imaging considerations (mammogram, ultrasound, and magnetic resonance imaging (MRI)), but have addressed only certain aspects of male breast cancer. […] The purpose of this review article was to provide a comprehensive overview of the imaging findings, optimal timing to obtain imaging, and the appropriate follow-up strategies in male breast cancer survivors. […] Male breast cancer poses diagnostic imaging challenges as benign breast conditions like gynecomastia must be differentiated from breast cancer. […] The sensitivity and specificity of mammogram in detecting male breast cancer is about 92-95% and 90-95%, respectively. […] The guidelines do not recommend screening mammography or MRI in male BRCA mutation carriers.
- #9 Diagnosing Male Breast Cancer | NYU Langone Healthhttps://nyulangone.org/conditions/male-breast-cancer/diagnosis
NYU Langone doctors have extensive experience diagnosing male breast cancer, a rare condition. They use sophisticated imaging and other tests to determine what type of breast cancer is present. […] After a physical exam, NYU Langone doctors may perform one or more diagnostic tests. […] Your NYU Langone doctor may use a mammogram, an X-ray of the breasts, to help diagnose male breast cancer. […] In ultrasound imaging, sound waves create images of the breasts. Ultrasound can help determine whether a breast mass found on a mammogram or a physical exam is solid or a cyst, meaning its fluid filled. […] If a suspicious mass is found, your NYU Langone doctor may use a core needle biopsy to determine whether the growth is breast cancer. […] NYU Langone pathologists, specialists who study diseases in a laboratory, examine tumor tissue under a microscope to determine whether breast cancer is present and, if it is, what type it is. […] Pathologists test tumor tissue for certain hormonal and genetic features, which can help your doctors decide how best to treat the cancer.
- #10 Male Breast Cancer: Imaging Considerations for Diagnosis and Surveillancehttps://pmc.ncbi.nlm.nih.gov/articles/PMC11161189/
The important mammogram findings observed were noncalcified mass alone (69%), a mass with microcalcifications (29%), and microcalcifications without a mass (2%). […] The mammographic appearance in male breast cancer usually occurs in a subareolar location with nipple involvement in 40-50% of cases. […] In general, on ultrasound male breast cancer appears as hypoechoic lesions with angulated, microlobulated, or spiculated margins. […] Breast MRI has been shown to have the highest sensitivity in detecting male breast cancer compared to ultrasound and mammogram. […] The absolute risk of second breast cancer in male breast cancer is less than 2%, and hence, in general, a follow-up mammogram is not routinely recommended for the early-stage disease. […] Imaging techniques in the male breast are done as a diagnostic tool. […] All imaging modalities have their unique advantages and applications in the diagnosis of male breast cancer.
- #11 Tests to Help Diagnose Breast Cancer in Men | American Cancer Societyhttps://www.cancer.org/cancer/types/breast-cancer-in-men/detection-diagnosis-staging/how-diagnosed.html
Breast ultrasound is often used to examine some types of breast changes. […] This test does not expose you to radiation. […] Breast ultrasound is often used to look at breast changes that are found during a mammogram or physical exam. […] In someone with a breast tumor, ultrasound can also be used to check if the lymph nodes under the arm are enlarged. […] When other tests show that you might have breast cancer, you will probably need to have a biopsy. […] A biopsy is the only sure way to diagnose breast cancer. […] Most biopsy results are not cancer, but a biopsy is the only way to find out. […] An FNA biopsy is the easiest type of biopsy to have, but it can sometimes miss a cancer if the needle does not go into the cancer cells. […] This is the most common type of biopsy used to make a breast cancer diagnosis.
- #12 Male Breast Cancer – Symptoms, Causes, Treatment | NBCFNational Breast Cancer Foundation logoNational Breast Cancer Foundation logohttps://nbcf.org.au/about-breast-cancer/further-information-on-breast-cancer/breast-cancer-in-men/
ABOUT 1 IN 550 MEN ARE DIAGNOSED […] Breast cancer in men […] In Australia, about one in 550 men will be diagnosed with breast cancer in their lifetime. […] It is important that men speak with their doctor as soon as possible if they notice any new or unusual breast changes. […] Cancer Australia recommends that men who detect any new or unusual breast changes see their doctor without delay. If the changes are caused by cancer, finding breast cancer early improves the chances that it can be treated successfully. […] Diagnosis of breast cancer in men […] Your doctor will investigate any new or unusual breast changes using a variety of diagnostic tests. These tests are the same as the ones used to study breast changes in women. They may include: Clinical breast examination, and taking a complete personal medical history. Mammogram â a low level x-ray of the breast. Though mammograms are not recommended for male breast cancer screening in Australia, they can be used to help diagnose breast cancer in men. Ultrasound â an imaging technique that uses sound waves to look at breast changes. It may help to determine whether a lump found in the breast is a fluid-filled cyst (which is unlikely to be cancer) or solid (which may require further testing to ensure it is not cancer). Biopsy â your doctor may recommend a biopsy if an abnormality is found during clinical examination and/or imaging tests. A biopsy involves removing a small sample of tissue and a specialist examining the sample under microscope. […] If you are diagnosed with breast cancer, your doctor may send you for further tests to help determine the extent of cancer spread in the body. Additional tests will be done to determine the molecular characteristics of the tumour, such the cancerâs hormone receptor status. These tests will help you and your doctors decide on the best treatment options.
- #13 Male Breast Cancer: Imaging Considerations for Diagnosis and Surveillancehttps://pmc.ncbi.nlm.nih.gov/articles/PMC11161189/
The important mammogram findings observed were noncalcified mass alone (69%), a mass with microcalcifications (29%), and microcalcifications without a mass (2%). […] The mammographic appearance in male breast cancer usually occurs in a subareolar location with nipple involvement in 40-50% of cases. […] In general, on ultrasound male breast cancer appears as hypoechoic lesions with angulated, microlobulated, or spiculated margins. […] Breast MRI has been shown to have the highest sensitivity in detecting male breast cancer compared to ultrasound and mammogram. […] The absolute risk of second breast cancer in male breast cancer is less than 2%, and hence, in general, a follow-up mammogram is not routinely recommended for the early-stage disease. […] Imaging techniques in the male breast are done as a diagnostic tool. […] All imaging modalities have their unique advantages and applications in the diagnosis of male breast cancer.
- #14 Tests to Help Diagnose Breast Cancer in Men | American Cancer Societyhttps://www.cancer.org/cancer/types/breast-cancer-in-men/detection-diagnosis-staging/how-diagnosed.html
Breast ultrasound is often used to examine some types of breast changes. […] This test does not expose you to radiation. […] Breast ultrasound is often used to look at breast changes that are found during a mammogram or physical exam. […] In someone with a breast tumor, ultrasound can also be used to check if the lymph nodes under the arm are enlarged. […] When other tests show that you might have breast cancer, you will probably need to have a biopsy. […] A biopsy is the only sure way to diagnose breast cancer. […] Most biopsy results are not cancer, but a biopsy is the only way to find out. […] An FNA biopsy is the easiest type of biopsy to have, but it can sometimes miss a cancer if the needle does not go into the cancer cells. […] This is the most common type of biopsy used to make a breast cancer diagnosis.
- #15 Male Breast Cancer: Imaging Considerations for Diagnosis and Surveillancehttps://pmc.ncbi.nlm.nih.gov/articles/PMC11161189/
The important mammogram findings observed were noncalcified mass alone (69%), a mass with microcalcifications (29%), and microcalcifications without a mass (2%). […] The mammographic appearance in male breast cancer usually occurs in a subareolar location with nipple involvement in 40-50% of cases. […] In general, on ultrasound male breast cancer appears as hypoechoic lesions with angulated, microlobulated, or spiculated margins. […] Breast MRI has been shown to have the highest sensitivity in detecting male breast cancer compared to ultrasound and mammogram. […] The absolute risk of second breast cancer in male breast cancer is less than 2%, and hence, in general, a follow-up mammogram is not routinely recommended for the early-stage disease. […] Imaging techniques in the male breast are done as a diagnostic tool. […] All imaging modalities have their unique advantages and applications in the diagnosis of male breast cancer.
- #16 Breast Cancer in Men > Fact Sheets > Yale Medicinehttps://www.yalemedicine.org/conditions/male-breast-cancer
Additional tests are required for diagnosis. Your doctor may order imaging tests such as a mammogram, ultrasound, or a magnetic resonance imaging (MRI) study of the affected breast. But to make a definitive diagnosis, a biopsy of the breast tissue is necessary. In this procedure, a small piece of breast tissue is removed, usually with a needle (though sometimes a surgical biopsy is required). A pathologist will analyze the tissue sample to check for the presence of cancer cells, and, if they are present, their hormone receptor and HER2 status. […] If the biopsy confirms a diagnosis of breast cancer, your doctor will order more tests to see whether the cancer has spread beyond the breast. This is known as staging. It may involve additional imaging tests such as a chest X-ray, positron emission tomography (PET), or a bone scan. In some cases, a sentinel lymph node biopsy is necessary.
- #17 Tests to Help Diagnose Breast Cancer in Men | American Cancer Societyhttps://www.cancer.org/cancer/types/breast-cancer-in-men/detection-diagnosis-staging/how-diagnosed.html
Breast ultrasound is often used to examine some types of breast changes. […] This test does not expose you to radiation. […] Breast ultrasound is often used to look at breast changes that are found during a mammogram or physical exam. […] In someone with a breast tumor, ultrasound can also be used to check if the lymph nodes under the arm are enlarged. […] When other tests show that you might have breast cancer, you will probably need to have a biopsy. […] A biopsy is the only sure way to diagnose breast cancer. […] Most biopsy results are not cancer, but a biopsy is the only way to find out. […] An FNA biopsy is the easiest type of biopsy to have, but it can sometimes miss a cancer if the needle does not go into the cancer cells. […] This is the most common type of biopsy used to make a breast cancer diagnosis.
- #18 Male Breast Cancer: Signs, Symptoms, Treatment & Morehttps://www.nationalbreastcancer.org/male-breast-cancer/
If you have family history or breast cancer symptoms, your doctor may recommend some of these diagnostic tests: Physical exam, Mammogram, Ultrasound, Biopsy. […] A breast biopsy is the only diagnostic test that can officially determine if the suspicious area is cancerous or not. […] If you are diagnosed with breast cancer, you may undergo additional tests at your physicianâs recommendation, such as blood marker tests, a chest x-ray, or a bone scan. […] A man diagnosed with breast cancer should consider genetic testing to determine if there is a mutation in a gene that can cause breast cancer. […] Treatment for male breast cancer varies based on the type and stage of cancer, with surgery being the main treatment for both women and men. […] The primary treatments for male breast cancer include: Surgery, Chemotherapy, Radiation, Hormonal therapy, Biologic targeted therapy. […] When detected in its earliest, localized stages, the 5-year relative survival rate of male breast cancer is 95%, according to the American Cancer Society.
- #19 Tests to Help Diagnose Breast Cancer in Men | American Cancer Societyhttps://www.cancer.org/cancer/types/breast-cancer-in-men/detection-diagnosis-staging/how-diagnosed.html
Breast ultrasound is often used to examine some types of breast changes. […] This test does not expose you to radiation. […] Breast ultrasound is often used to look at breast changes that are found during a mammogram or physical exam. […] In someone with a breast tumor, ultrasound can also be used to check if the lymph nodes under the arm are enlarged. […] When other tests show that you might have breast cancer, you will probably need to have a biopsy. […] A biopsy is the only sure way to diagnose breast cancer. […] Most biopsy results are not cancer, but a biopsy is the only way to find out. […] An FNA biopsy is the easiest type of biopsy to have, but it can sometimes miss a cancer if the needle does not go into the cancer cells. […] This is the most common type of biopsy used to make a breast cancer diagnosis.
- #20 Male Breast Cancer Diagnosis and Detection: Biopsy | Memorial Sloan Kettering Cancer Centerhttps://www.mskcc.org/cancer-care/types/breast-male/diagnosis/detection
A biopsy is done if the results of either a physical examination or imaging tests, such as a mammogram or ultrasound, show a concerning change in the breast. During a breast biopsy, a sample of tissue is taken from the breast. A pathologist a doctor who is trained to diagnose disease then examines the cells or tissue under a microscope to determine whether or not they are cancerous. […] There are different types of biopsy methods. These include: […] A core needle biopsy may be used if the pathologist needs a larger tissue sample than what can be obtained with a fine needle aspiration. It can also be used if the tissue removed during a fine needle aspiration did not yield a definitive diagnosis. […] A surgical biopsy may be done if other biopsy procedures do not provide a definitive diagnosis. A surgical biopsy is also performed if the suspicious area is too deep or too shallow for a core needle biopsy.
- #21 Male Breast Cancer – StatPearls – NCBI Bookshelfhttps://www.ncbi.nlm.nih.gov/books/NBK526036/
Similar to breast cancer in women, the diagnosis of MBC is made by a triple assessment, which includes clinical assessment, mammography, ultrasonography, and core biopsy. Mammography is an effective diagnostic method with a sensitivity of 92% and a specificity of 90%; although due to size and volume differences in male breasts, this modality may be limited at times. Given this, ultrasound-guided core biopsy gives the most definitive diagnosis of MBC and is preferred over fine-needle aspiration. […] Treatment and management of male breast cancer typically follow the same rationale as breast cancer in women, which consists of resection followed by adjuvant endocrine therapy, chemotherapy (CT), or radiotherapy. Management is guided by prognostic factors and is further discussed in the oncology section.
- #22 Male Breast Cancer Diagnosis and Detection: Biopsy | Memorial Sloan Kettering Cancer Centerhttps://www.mskcc.org/cancer-care/types/breast-male/diagnosis/detection
A surgical biopsy takes place in an operating room, but it does not usually require an overnight stay in the hospital. During a surgical biopsy, the patient undergoes twilight sedation but does not require general anesthesia. A small incision is made on the breast, then the suspicious breast tissue is removed entirely, or a representative sample is removed for analysis.
- #23 Male Breast Cancer – StatPearls – NCBI Bookshelfhttps://www.ncbi.nlm.nih.gov/books/NBK526036/
Similar to breast cancer in women, the diagnosis of MBC is made by a triple assessment, which includes clinical assessment, mammography, ultrasonography, and core biopsy. Mammography is an effective diagnostic method with a sensitivity of 92% and a specificity of 90%; although due to size and volume differences in male breasts, this modality may be limited at times. Given this, ultrasound-guided core biopsy gives the most definitive diagnosis of MBC and is preferred over fine-needle aspiration. […] Treatment and management of male breast cancer typically follow the same rationale as breast cancer in women, which consists of resection followed by adjuvant endocrine therapy, chemotherapy (CT), or radiotherapy. Management is guided by prognostic factors and is further discussed in the oncology section.
- #24 Tests to Help Diagnose Breast Cancer in Men | American Cancer Societyhttps://www.cancer.org/cancer/types/breast-cancer-in-men/detection-diagnosis-staging/how-diagnosed.html
If the results of the CNB do not give a clear diagnosis, or your doctor still has concerns, you might need to have a second biopsy or a different type of biopsy. […] Most breast cancer can be diagnosed with a needle biopsy. […] The doctor may also need to biopsy the lymph nodes under the arm to check them for cancer spread.
- #25 Breast cancer in men | Canadian Cancer Societyhttps://cancer.ca/en/cancer-information/cancer-types/breast/what-is-breast-cancer/breast-cancer-in-men
Breast cancer cells can break away from a tumour and travel through the lymphatic system to lymph nodes. […] A lymph node biopsy is used to remove lymph nodes so they can be examined under a microscope to find out if they have cancer in them. […] Hormone receptor status testing is used to find out if the breast cancer cells have estrogen receptors (ERs), progesterone receptors (PRs) or both. […] Most breast cancers found in men are estrogen receptor positive (ER+) and progesterone receptor positive (PR+). […] HER2 status testing is done to find out if the breast cancer cells are making more HER2 protein than normal (called overexpression). […] Only a small number of breast cancers in men are HER2 positive. […] Your doctor may order other tests to check your general health. You may also have tests to find out if the cancer has spread (metastasized) to other parts of the body.
- #26 Azthena logo with the word Azthenahttps://www.news-medical.net/health/Diagnosis-of-male-breast-cancer.aspx
The affected lymph node in the armpit may also be removed and examined to check for possible spread of the cancer. This is called sentinel lymph node biopsy. […] Once diagnosis is made the cancer needs to be staged. This helps in determining appropriate treatment regimen as well as predicts the outcome of therapy.
- #27 Tests and next steps for breast cancer in men – NHShttps://www.nhs.uk/conditions/breast-cancer-in-men/tests-and-next-steps-for-breast-cancer-in-men/
You may be referred to a breast clinic if a GP thinks you have possible breast cancer symptoms that need investigating. […] At the breast clinic, you will have more tests and scans to check for breast cancer or other breast conditions. […] These may include: an examination of your chest, an X-ray of your breast tissue (mammogram), an ultrasound of your breast tissue, taking a small sample of cells (biopsy), usually using a needle, to test for breast cancer and look for certain proteins in the breast cancer cells (which can help decide which treatments are best). […] You may not need all these tests. You will usually have all the tests you need in 1 visit at the breast clinic. […] If you’ve been told you have breast cancer, you may need more tests. These can include: a chest X-ray, scans, such as a CT scan, MRI scan, or a bone scan, blood tests. […] The results of these tests will help show how far the cancer has spread, what type of breast cancer it is, and if the cancer has been caused by certain changes in your genes. […] The specialists will use the results of these tests and talk to you about the best treatment for you.
- #28 Male Breast Cancer: Tests After Diagnosis | UMass Memorial Healthhttps://www.ummhealth.org/health-library/male-breast-cancer-tests-after-diagnosis
You likely will need additional tests to help your provider learn more about the cancer. […] After going through a breast cancer diagnosis, you might feel like you’ve had your fill of tests and exams. But for many men, you will likely need more tests. These help your healthcare providers learn more about the cancer. They can help show if it has grown into nearby areas or spread to other parts of your body. The test results help your healthcare providers decide the best ways to treat the cancer. […] Your provider will walk you through which of these imaging tests you may need. […] Lab tests will be done on the sample of cells that was taken during your breast biopsy. From these tests, your healthcare provider will learn if the tumor needs certain hormones to grow. Tumors that need hormones to grow are called hormone-receptor positive (HR+). This is because they have receptors for either estrogen (ER+) or progesterone (PR+).
- #29 Male Breast Cancer: Symptoms, Treatment and Survival Ratehttps://www.cancercenter.com/cancer-types/breast-cancer/types/rare-breast-cancer-types/breast-cancer-in-men
Men tend to be diagnosed with breast cancers that are hormone receptor-positive and HER2-negative. […] The spread of cancer from breast to lymph nodes and other parts of the body in men appears to be similar to what women experience. […] The stage of breast cancer is determined by your care team based on: The size and location of the cancer, Whether it has spread to nearby lymph nodes or other parts of the body, The grade of the tumoror how likely it is to grow and spread, Whether certain biomarkershormone receptors or other proteinsare present. […] Tests to help with determining the stage of the cancer are: A biopsy of the sentinel lymph nodes, which are removed during surgery, A chest X-ray or CT scan, A bone scan, in which radioactive material is injected into a vein and then can be detected by a scanner, A PET scan, which scans the body after glucose is injected in a vein (malignant cells are brighter in the picture).
- #30 Male breast cancer | Radiology Reference Article | Radiopaedia.orghttps://radiopaedia.org/articles/male-breast-cancer?lang=us
Male breast cancer is exceptionally rare and only accounts for less than 0.25% of male malignancies and ~0.5-1% of all breast cancer (both genders). The diagnosis is sometimes delayed due to the patient’s hesitancy to seek advice. Workup from a radiological point of view is the same as for women, including the use of needle biopsy to confirm the diagnosis. […] The average age of diagnosis of male breast cancer is 60-70 years, which is later than female breast cancer. […] Most commonly, men present with a painless subareolar mass. Male breast cancer is also reported to present at a relatively advanced stage compared with female breast cancer. […] Histologically, the vast majority are invasive ductal carcinoma (85-90%) or ductal carcinoma in situ. It should be noted that invasive lobular carcinoma is extremely rare in male patients because lobules and acini are not found in normal male breast tissue. […] The overall prognosis tends to be worse than for female breast cancer, possibly due to the fact that men seek medical attention for the mass at later stages (i.e. when the mass has already become palpable).
- #31 Male breast cancer – Symptoms and causes – Mayo Clinichttps://www.mayoclinic.org/diseases-conditions/male-breast-cancer/symptoms-causes/syc-20374740
Types of male breast cancer include: Cancer that begins in the milk ducts, called ductal carcinoma. This type of breast cancer starts in the tubes that connect to the nipple. These tubes are called ducts. Ductal carcinoma is the most common type of male breast cancer. […] Cancer that begins in the milk-producing glands, called lobular carcinoma. This type of cancer begins in the glands that have the potential to make breast milk. These glands are called lobules. Lobular carcinoma is less common in people assigned male at birth because they usually have fewer lobular cells. […] Other types of cancer. Other, rarer types of male breast cancer include Paget’s disease of the nipple and inflammatory breast cancer. […] The risk of breast cancer increases with age. Male breast cancer is most often diagnosed in men in their 60s.
- #32 Male breast cancer | Radiology Reference Article | Radiopaedia.orghttps://radiopaedia.org/articles/male-breast-cancer?lang=us
Male breast cancer is exceptionally rare and only accounts for less than 0.25% of male malignancies and ~0.5-1% of all breast cancer (both genders). The diagnosis is sometimes delayed due to the patient’s hesitancy to seek advice. Workup from a radiological point of view is the same as for women, including the use of needle biopsy to confirm the diagnosis. […] The average age of diagnosis of male breast cancer is 60-70 years, which is later than female breast cancer. […] Most commonly, men present with a painless subareolar mass. Male breast cancer is also reported to present at a relatively advanced stage compared with female breast cancer. […] Histologically, the vast majority are invasive ductal carcinoma (85-90%) or ductal carcinoma in situ. It should be noted that invasive lobular carcinoma is extremely rare in male patients because lobules and acini are not found in normal male breast tissue. […] The overall prognosis tends to be worse than for female breast cancer, possibly due to the fact that men seek medical attention for the mass at later stages (i.e. when the mass has already become palpable).
- #33 Lab Tests to Help Classify Breast Cancer in Men | American Cancer Societyhttps://www.cancer.org/cancer/types/breast-cancer-in-men/detection-diagnosis-staging/classifying.html
Breast cancer is classified in different ways, based on the results of lab tests after biopsy or surgery. Breast cancer is given a type, based on the type of cells it started from; a grade, based on how the cells look and how quickly they grow; and other classifications based on the results of tests for different hormone receptors or genes or proteins in the cancer cells. […] The biopsy is also used to determine the cancer’s type, such as invasive ductal carcinoma or invasive lobular carcinoma. […] Cancer cells are given a grade when they are removed from the breast and checked in the lab. The grade is based on how much the cancer cells look like normal breast cells. […] The grade is used to help predict your outcome (prognosis) and help figure out what treatments might work best. […] Knowing the hormone receptor status is important in deciding treatment options.
- #34 Breast Cancer in Men: Overview of Male Breast Cancer, Etiology, Diagnosishttps://emedicine.medscape.com/article/1954174-overview
Most male breast cancers (~80%) are hormone receptor positive, 15% overexpress human epidermal growth factor receptor 2 (HER2), and 4% are triple negative (estrogen receptor, progesterone receptor, and HER2 negative). […] The US Food and Drug Administration (FDA) has issued a draft guidance encouraging the inclusion of male patients in breast cancer clinical trials, noting that many treatments are approved for women only and further data may be necessary to support approval for use in men. […] Recommendations for use of systemic therapy in male breast cancer are generally the same as in female breast cancer, because the rarity of male breast cancer has precluded the performance of clinical studies. […] ASCO guidelines recommend that men with advanced or metastatic, hormone receptor positive, HER2-negative breast cancer should be offered endocrine therapy as first-line therapy, except in cases of visceral crisis or rapidly progressive disease. […] Men who have had breast cancer are at increased risk for a second ipsilateral or contralateral breast cancer, as well as for second primary colorectal, pancreatic and thyroid cancers. […] The risk of breast cancer recurrence continues beyond 15 years after primary treatment.
- #35 Male Breast Cancer Statistics and Research | BCRFhttps://www.bcrf.org/about-breast-cancer/male-breast-cancer-statistics-research/
Most breast cancers in men are estrogen receptor (ER)positive invasive ductal carcinoma. […] Even when a man sees his primary care physician with unusual chest symptoms, neither the doctor nor the patient expects breast cancerand so it often goes undiagnosed until it is more advanced. […] Unfortunately, there has been little research in male breast cancer, especially in how best to treat it, in part because of the diseases rarity and lack of surveillance. […] Men are often excluded fromor at least not actively recruited tobreast cancer clinical trials. […] As a result, treatment in men is much the same as treatment in women, with anti-hormone drugs such as tamoxifen and chemotherapy. […] Pioneering work by Dr. Fatima Cardoso and the BCRF-supported International Male Breast Cancer Program suggests that men are frequently undertreated for breast cancer.
- #36 Lab Tests to Help Classify Breast Cancer in Men | American Cancer Societyhttps://www.cancer.org/cancer/types/breast-cancer-in-men/detection-diagnosis-staging/classifying.html
All newly-diagnosed breast cancers should be tested for HER2 because the outlook for people with HER2-positive cancers is improved if drugs that target the HER2 protein, such as trastuzumab (Herceptin) and lapatinib (Tykerb) are used as part of treatment. […] Doctors often divide invasive breast cancers into groups based on the presence of hormone receptors (ER and PR) and whether or not the cancer has too much HER2. […] Breast cancers in men that are hormone receptor-positive can be treated with hormone therapy drugs that lower estrogen levels, block estrogen receptors, or affect androgen (male hormone) levels. […] If the breast cancer cells don’t have either estrogen or progesterone receptors, they are said to be hormone receptor-negative (or just hormone-negative). Treatment with hormone therapy drugs is not helpful for these cancers.
- #37 Lab Tests to Help Classify Breast Cancer in Men | American Cancer Societyhttps://www.cancer.org/cancer/types/breast-cancer-in-men/detection-diagnosis-staging/classifying.html
Breast cancer is classified in different ways, based on the results of lab tests after biopsy or surgery. Breast cancer is given a type, based on the type of cells it started from; a grade, based on how the cells look and how quickly they grow; and other classifications based on the results of tests for different hormone receptors or genes or proteins in the cancer cells. […] The biopsy is also used to determine the cancer’s type, such as invasive ductal carcinoma or invasive lobular carcinoma. […] Cancer cells are given a grade when they are removed from the breast and checked in the lab. The grade is based on how much the cancer cells look like normal breast cells. […] The grade is used to help predict your outcome (prognosis) and help figure out what treatments might work best. […] Knowing the hormone receptor status is important in deciding treatment options.
- #38 Male Breast Cancer – StatPearls – NCBI Bookshelfhttps://www.ncbi.nlm.nih.gov/books/NBK526036/
The staging workup regarding male breast cancer is classified similarly to breast cancer in women and consists of the tumor, node, and metastasis (TMN) staging system. Unfortunately, due to the common delayed diagnosis of breast cancer in men, approximately 40% of all breast cancer at the initial diagnosis is found to be stage III or IV disease. […] Due to delayed diagnosis commonly found in male breast cancer, the overall 5-year survival is approximately 40% to 65%. When stratified, stage I is 75% to 100%, stage II is 50% to 80%, stage III is 30% to 60%, and stage IV is 20% to 30%. […] Routine screening of men with breast cancer is not established due to the rarity of occurrence. Yet, men (especially those older than 35) should be educated on the potential risk factors discussed and be advised on genetic counseling if they have a family history of breast cancer (in both males and females) or other cancers that may be triggered by a BRCA gene, for example, ovarian, pancreatic, testicular, or prostate cancers.
- #39 Male Breast Cancer: Symptoms, Treatment and Survival Ratehttps://www.cancercenter.com/cancer-types/breast-cancer/types/rare-breast-cancer-types/breast-cancer-in-men
Men tend to be diagnosed with breast cancers that are hormone receptor-positive and HER2-negative. […] The spread of cancer from breast to lymph nodes and other parts of the body in men appears to be similar to what women experience. […] The stage of breast cancer is determined by your care team based on: The size and location of the cancer, Whether it has spread to nearby lymph nodes or other parts of the body, The grade of the tumoror how likely it is to grow and spread, Whether certain biomarkershormone receptors or other proteinsare present. […] Tests to help with determining the stage of the cancer are: A biopsy of the sentinel lymph nodes, which are removed during surgery, A chest X-ray or CT scan, A bone scan, in which radioactive material is injected into a vein and then can be detected by a scanner, A PET scan, which scans the body after glucose is injected in a vein (malignant cells are brighter in the picture).
- #40 Male Breast Cancer – StatPearls – NCBI Bookshelfhttps://www.ncbi.nlm.nih.gov/books/NBK526036/
The staging workup regarding male breast cancer is classified similarly to breast cancer in women and consists of the tumor, node, and metastasis (TMN) staging system. Unfortunately, due to the common delayed diagnosis of breast cancer in men, approximately 40% of all breast cancer at the initial diagnosis is found to be stage III or IV disease. […] Due to delayed diagnosis commonly found in male breast cancer, the overall 5-year survival is approximately 40% to 65%. When stratified, stage I is 75% to 100%, stage II is 50% to 80%, stage III is 30% to 60%, and stage IV is 20% to 30%. […] Routine screening of men with breast cancer is not established due to the rarity of occurrence. Yet, men (especially those older than 35) should be educated on the potential risk factors discussed and be advised on genetic counseling if they have a family history of breast cancer (in both males and females) or other cancers that may be triggered by a BRCA gene, for example, ovarian, pancreatic, testicular, or prostate cancers.
- #41 Male Breast Cancer: Signs, Symptoms, Treatment & Morehttps://www.nationalbreastcancer.org/male-breast-cancer/
If you have family history or breast cancer symptoms, your doctor may recommend some of these diagnostic tests: Physical exam, Mammogram, Ultrasound, Biopsy. […] A breast biopsy is the only diagnostic test that can officially determine if the suspicious area is cancerous or not. […] If you are diagnosed with breast cancer, you may undergo additional tests at your physicianâs recommendation, such as blood marker tests, a chest x-ray, or a bone scan. […] A man diagnosed with breast cancer should consider genetic testing to determine if there is a mutation in a gene that can cause breast cancer. […] Treatment for male breast cancer varies based on the type and stage of cancer, with surgery being the main treatment for both women and men. […] The primary treatments for male breast cancer include: Surgery, Chemotherapy, Radiation, Hormonal therapy, Biologic targeted therapy. […] When detected in its earliest, localized stages, the 5-year relative survival rate of male breast cancer is 95%, according to the American Cancer Society.
- #42 Male Breast Cancer Treatmenthttps://www.komen.org/breast-cancer/treatment/by-diagnosis/male-breast-cancer/
Breast cancer can occur in men. This may be called male breast cancer. In 2025, its estimated 2,800 new cases of male breast cancer will be diagnosed in the U.S. […] Male breast cancers tend to be hormone receptor-positive and HER2-negative. […] The National Comprehensive Cancer Network (NCCN) recommends all men diagnosed with breast cancer get genetic testing for BRCA1 and BRCA2 (BRCA1/2) inherited gene mutations. […] Genetic testing is recommended for all men diagnosed with breast cancer to learn if the breast cancer is related to an inherited gene mutation. […] Men who have a BRCA2 inherited gene mutation, and to a lesser degree men who have a BRCA1 mutation, have an increased risk of breast cancer. […] Treatment for breast cancer in men is similar to treatment for women. […] Most male breast cancers are hormone receptor-positive.
- #43 Male Breast Cancer Treatmenthttps://www.komen.org/breast-cancer/treatment/by-diagnosis/male-breast-cancer/
Breast cancer can occur in men. This may be called male breast cancer. In 2025, its estimated 2,800 new cases of male breast cancer will be diagnosed in the U.S. […] Male breast cancers tend to be hormone receptor-positive and HER2-negative. […] The National Comprehensive Cancer Network (NCCN) recommends all men diagnosed with breast cancer get genetic testing for BRCA1 and BRCA2 (BRCA1/2) inherited gene mutations. […] Genetic testing is recommended for all men diagnosed with breast cancer to learn if the breast cancer is related to an inherited gene mutation. […] Men who have a BRCA2 inherited gene mutation, and to a lesser degree men who have a BRCA1 mutation, have an increased risk of breast cancer. […] Treatment for breast cancer in men is similar to treatment for women. […] Most male breast cancers are hormone receptor-positive.
- #44 Male Breast Cancer: An Overshadowed Diagnosis – Breast Cancer Actionhttps://www.bcaction.org/male-breast-cancer-an-overshadowed-diagnosis/
Many of us are aware that men can and do get breast cancer, but few of us know any more than that. […] About 1,300 men were diagnosed with breast cancer last year, according to the American Cancer Society. […] A study of 217 men with breast cancer who were treated at 18 different U.S. hospitals showed that the men waited an average of ten months after symptoms appeared before consulting a doctor. […] Male breast cancer often first appears as a small, hard, painless lump in the nipple area; researchers believe it tends to occur there in men because most men have small, undeveloped vestiges of milk ducts beneath the areola and nipple. […] Although breast cancer is rare in men, any of these symptoms warrants a visit to a physician. […] Statistically, most men are diagnosed between the ages of 60 and 70, although men of all ages can develop the disease.
- #45 Experiences and perceptions of men following breast cancer diagnosis: a mixed method systematic review | BMC Cancer | Full Texthttps://bmccancer.biomedcentral.com/articles/10.1186/s12885-024-11911-9
Men with breast cancer experience unique physical and emotional challenges. […] Evidence suggests that MBC is mostly diagnosed late (49%) when the disease is more advanced compared to women (33%) leading to relatively worse prognosis. […] Consequently, MBCs are mainly diagnosed with more severe clinical manifestations with relatively complex tumour characteristics (i.e., larger sizes and extensive lymph node involvement), associated with higher proportions of positive hormone receptors, which mostly results in prolonged treatment delay, and metastasis of the disease at diagnosis compared to female breast cancer. […] Treatment for MBC has mainly been informed by available evidence for female breast cancer, and no randomised data exists for optimal management strategies for men including surgery, systemic therapy, and radiation.
- #46 Examining stigma in experiences of male breast cancer patients and its impact as a barrier to care: a narrative review – Raeisi Dehkordi – Annals of Palliative Medicinehttps://apm.amegroups.org/article/view/128974/html
The authors determined that nearly 64.2% of patients felt moderate (or higher) embarrassment during the presentation of symptoms, and 67.8% of patients experienced this at the breast clinic. Oftentimes, patients attributed these feelings to being isolated in the clinic and treatment centers, as there were a greater number of FBC patients present. This suggests that men feel especially excluded during chemotherapy and radiation therapy while being treated in a clinic filled with female patients, and designed for FBC. […] This review has identified the main roots of MBC stigmatization to be the lack of awareness among healthcare professionals and the patients own feelings of embarrassment. As such, this stigmatization leads to the creation of barriers for MBC patients when accessing health care. The study by Co et al. interviewed 56 MBC patients and determined that the time between onset of symptoms to diagnosis ranged from 1 to 10 years among participants. The authors also suggested that this is mainly due to feelings of embarrassment experienced by patients during hospitalization, as well as lack of awareness amongst the public.
- #47 Low Patient Awareness Hinders Male Breast Cancer Diagnosis | North Kansas City Hospitalhttps://www.nkch.org/blog/low-patient-awareness-hinders-male-breast-cancer-diagnosis
More than 30 years after Breast Cancer Awareness Month was established, October has become synonymous with early breast cancer detection and treatment. The incidence of breast cancer in men is rare compared to the incidence in women, with less than 1% of all breast cancers occurring in men. Breast cancer in men is typically identified at a more advanced stage. […] Late-stage diagnosis is due to several issues: Lack of awareness about male breast cancer, Patient procrastination in seeking medical care, Male embarrassment about physical changes in the breast or chest areas. When men present with breast cancer, its typically advanced by the time they feel a painless lump under their areola (pigmented area around the nipple) or a lump in their armpit. Yet, men tend to ignore their symptoms, which is due, in part, to a lack of awareness.
- #48 Examining stigma in experiences of male breast cancer patients and its impact as a barrier to care: a narrative review – Raeisi Dehkordi – Annals of Palliative Medicinehttps://apm.amegroups.org/article/view/128974/html
The authors determined that nearly 64.2% of patients felt moderate (or higher) embarrassment during the presentation of symptoms, and 67.8% of patients experienced this at the breast clinic. Oftentimes, patients attributed these feelings to being isolated in the clinic and treatment centers, as there were a greater number of FBC patients present. This suggests that men feel especially excluded during chemotherapy and radiation therapy while being treated in a clinic filled with female patients, and designed for FBC. […] This review has identified the main roots of MBC stigmatization to be the lack of awareness among healthcare professionals and the patients own feelings of embarrassment. As such, this stigmatization leads to the creation of barriers for MBC patients when accessing health care. The study by Co et al. interviewed 56 MBC patients and determined that the time between onset of symptoms to diagnosis ranged from 1 to 10 years among participants. The authors also suggested that this is mainly due to feelings of embarrassment experienced by patients during hospitalization, as well as lack of awareness amongst the public.
- #49 Breast Cancer in Males: Symptoms, Causes, Diagnosis, Treatmenthttps://www.verywellhealth.com/male-breast-cancer-513617
While those assigned female at birth who are over 40 are advised to get screening mammograms, people assigned male at birth are not generally advised to have this test because it is low yield for people who have a low risk of breast cancer. […] The diagnosis of breast cancer in cisgender men is usually initiated after symptoms develop. In these cases, a mammogram may be used for diagnostic purposes. A healthcare provider may also order a breast magnetic resonance imaging (MRI) scan and a biopsy (removing a sample tissue for testing in a lab) to identify the tumor, and determine its stage, grade, and type. […] Diagnostic testing includes mammograms, magnetic resonance imaging (MRI), and biopsy.
- #50 Male Breast Cancer: Imaging Considerations for Diagnosis and Surveillancehttps://pmc.ncbi.nlm.nih.gov/articles/PMC11161189/
Male breast cancer accounts for less than 1% of all breast cancer cases. […] Despite its rarity, numerous studies have investigated the data on imaging considerations (mammogram, ultrasound, and magnetic resonance imaging (MRI)), but have addressed only certain aspects of male breast cancer. […] The purpose of this review article was to provide a comprehensive overview of the imaging findings, optimal timing to obtain imaging, and the appropriate follow-up strategies in male breast cancer survivors. […] Male breast cancer poses diagnostic imaging challenges as benign breast conditions like gynecomastia must be differentiated from breast cancer. […] The sensitivity and specificity of mammogram in detecting male breast cancer is about 92-95% and 90-95%, respectively. […] The guidelines do not recommend screening mammography or MRI in male BRCA mutation carriers.
- #51 Male Breast Cancer: Imaging Considerations for Diagnosis and Surveillance | Thomas | Journal of Clinical Medicine Researchhttps://www.jocmr.org/index.php/JOCMR/article/view/5169/25893859
The sensitivity and specificity of mammogram in detecting male breast cancer is about 92-95% and 90-95%, respectively. […] The National Comprehensive Cancer Network (NCCN) guidelines recommend that men with BRCA mutations get training for breast self-examination and start receiving yearly clinical breast examinations from 35 years of age. […] The guidelines do not recommend screening mammography or MRI in male BRCA mutation carriers. […] The mammogram findings suggestive of cancer include irregular mass with spiculated or indistinct margins. […] Calcifications are present in 9-31% of male breast cancer cases but are fewer in number, coarser, and less frequently rod-shaped compared to female breast cancer. […] The absolute risk of second breast cancer in male breast cancer is less than 2%, and hence, in general, a follow-up mammogram is not routinely recommended for the early-stage disease. […] Imaging techniques in the male breast are done as a diagnostic tool. […] All imaging modalities have their unique advantages and applications in the diagnosis of male breast cancer.
- #52 Article: The diagnosis of male breast cancer (full text) – December 2019 – NJMhttps://www.njmonline.nl/article_ft.php?a=2169&d=1429&i=231
The diagnosis of male breast cancer can made in most cases by triple assessment: clinical assessment, radiologic assessment (mammography and ultrasound examination), and tissue biopsy (fine-needle aspiration cytology or core biopsy), exactly as in female breast cancer. […] Clinical evaluation should look specifically for male breast cancers risk factors which are divided into high risk groups such as advanced age, antiandrogens therapy, radiotherapy and hormonal imbalance as in liver failure, and strong family history due to BRCA 2 mutations. […] The diagnosis of male breast cancer should follow simple orderly steps similar to female breast cancer diagnosis. Careful attention and good evaluation for breast complaints, especially in high-risk patients, is essential to avoid misdiagnosis.
- #53 Experiences and perceptions of men following breast cancer diagnosis: a mixed method systematic review | BMC Cancer | Full Texthttps://bmccancer.biomedcentral.com/articles/10.1186/s12885-024-11911-9
The breast cancer diagnosis which commenced the illness trajectory was really challenging for the men and filled with varied emotions. […] Professional support should therefore not end after the diagnosis phase but should extend to the entire treatment continuum and aftercare. […] Awareness creation efforts of MBC among the public as well as healthcare practitioners are urgently required to explain to the public through television programmes and awareness meetings that breast cancer is a disease like any other that affects both men and women. […] Research will be needed to develop and test testosterone-preserving treatment modalities or optimising existing therapies in a way that is relevant to the priorities of MBC.
- #54 Male breast cancer: Symptoms, statistics, tests, and treatmenthttps://www.medicalnewstoday.com/articles/179457
Male breast cancer is a relatively rare cancer, but it is one that doctors often diagnose in the later stages. Knowing how to recognize the symptoms can help a person get early treatment. […] The outlook for male breast cancer is excellent if diagnosis occurs in its early stages. However, early diagnosis is not always possible. […] For these and other reasons, around 40% of males with breast cancer receive a diagnosis in stage 3 or 4, when the condition has already spread to other parts of the body. […] For this reason, it is essential to seek help as soon as a person notices any changes in the breast. Early stage breast cancer responds well to treatment. […] If a person notices changes in their breast, they should contact a doctor. […] They may also suggest the following tests: a mammogram, an ultrasound, a nipple discharge test, a biopsy.
- #55 Male Breast Cancer Treatmenthttps://www.komen.org/breast-cancer/treatment/by-diagnosis/male-breast-cancer/
For men with hormone receptor-positive breast cancers, the hormone therapy drug tamoxifen, with or without the CDK4/6 inhibitor abemaciclib (Verzenio), is usually the first drug therapy used. […] For men with hormone receptor-negative breast cancer, chemotherapy is usually the first drug therapy used. […] The chances of survival for breast cancer in men are similar to the chances of survival in women of the same age and cancer stage. […] However, men are often diagnosed at a later stage than women. […] Although the exact treatment for breast cancer varies from person to person, evidence-based guidelines help make sure high-quality care is given.
- #56 Important Numbers to Know About Male Breast Cancerhttps://www.healthline.com/health/breast-cancer/male-breast-cancer-statistics
Male breast cancer treatment has evolved through the years. It is better today than it once was. […] Treatment options and outcomes depend on the stage of cancer. […] According to the American Cancer Society, the 5-year relative survival rates for male breast cancer are: Localized: 95%, Regional: 84%, Distant: 20%. […] The overall 5-year relative survival rate for male breast cancer is 83%, according to the ACS when looking at all cases in the database for all breast cancer stages in males. […] Male breast cancer is a rarer type of cancer. Because of this, diagnosis may be delayed in certain cases. […] Knowing the signs and symptoms of male breast cancer and reaching out to a doctor about any concerns can improve outcomes.
- #57 Early Detection and Diagnosis of Male Breast Cancer | Symptoms, Treatment, & Outcomeshttps://www.nanavatimaxhospital.org/blogs/early-diagnosis-male-breast-cancer
Male breast cancer, though rare, occurs when cancer cells develop in the breast tissue of men, typically between the ages of 60 and 70. Early detection and diagnosis are critical for improving outcomes. […] Early detection can dramatically improve survival rates. Regular screenings, self-examinations, and awareness of potential symptoms are vital in identifying male breast cancer in its early stages. […] Accurate diagnosis involves a combination of physical examinations and advanced tests: […] A biopsy confirms whether a detected lump is cancerous by extracting and examining tissue samples. It remains the gold standard for diagnosing male breast cancer. […] When detected early, treatments are more effective, and survival rates improve significantly. For example, stage 1 breast cancer has a nearly 100% five-year survival rate.