Materiały źródłowe

• #1 Uterine (Endometrial) Cancer Stages

  https://www.webmd.com/cancer/cervical-cancer/uterine-cancer-stages

  Endometrial cancer often begins in the uterine lining. It’s also called uterine cancer. It’s the most common female reproductive cancer. In fact, uterine cancer is the fourth most common cancer for women in the U.S. […] Although there are many types of uterine cancer, most are endometrial. It starts in the inner lining of your uterus. […] The most common symptom is bleeding that isn’t normal. That can mean spotting or bleeding between your menstrual periods. You may also have watery or blood-tinged discharge from your vagina. […] If you’ve gone through menopause, any vaginal bleeding can be a symptom. Typically, uterine cancer is diagnosed around 60 years of age. So its unusual to menstruate at this stage in life. […] Keep in mind that not everyone has bloody discharge. Sometimes, non-bloody vaginal discharge can signal uterine cancer, too.

• #2 Uterine cancer – Wikipedia

  https://en.wikipedia.org/wiki/Uterine_cancer

  Symptoms of endometrial cancer include changes in vaginal bleeding or pain in the pelvis. […] Both types of uterine cancer can present with abnormal vaginal bleeding and discharge. Abnormalities can include change in duration or amount of menstrual bleeding as well as new bleeding between menses or after menopause. Sensations of new or increasing pelvic pressure or pain can also indicate tumor growth in the uterus. […] Endometrial cancer typically has a good 5-year-survival when diagnosed early. Generally, the prognosis is poorer for uterine sarcomas as compared to endometrial cancers.

• #3 Endometriosis vs. Endometrial Cancer | OCRA

  https://ocrahope.org/news/endometriosis-and-endometrial-cancer-differences/

  Endometrial cancer is a malignant tumor that develops from the endometrial lining inside the uterus. […] Endometrial cancer is the most common gynecologic cancer. Each year about 66,000 new cases are diagnosed in the U.S., and some 600,000 Americans are living with endometrial cancer. The average age at diagnosis is 60. Endometrial cancer is rare among women younger than 45. […] Endometrial cancer symptoms include bleeding or spotting after menopause, unusual vaginal bleeding or bleeding between periods before menopause, pelvic pain, and painful urination.

• #4 Endometriosis vs. Endometrial Cancer | OCRA

  https://ocrahope.org/news/endometriosis-and-endometrial-cancer-differences/

  Endometrial cancer is a malignant tumor that develops from the endometrial lining inside the uterus. […] Endometrial cancer is the most common gynecologic cancer. Each year about 66,000 new cases are diagnosed in the U.S., and some 600,000 Americans are living with endometrial cancer. The average age at diagnosis is 60. Endometrial cancer is rare among women younger than 45. […] Endometrial cancer symptoms include bleeding or spotting after menopause, unusual vaginal bleeding or bleeding between periods before menopause, pelvic pain, and painful urination.

• #5 What Are the First Signs of Uterine Cancer?

  https://www.aarp.org/health/conditions-treatments/info-2024/uterine-cancer-symptoms.html

  When Ursula Matulonis, M.D., started treating women with gynecologic cancers more than 20 years ago, she says it was rare to see a patient who had an aggressive form of uterine cancer. […] Now I see several per week, says Matulonis, chief of the division of gynecologic oncology at Dana-Farber Cancer Institute in Boston and a professor of medicine at Harvard Medical School. […] The most common symptom of uterine cancer is abnormal bleeding after menopause. (The average age of uterine cancer diagnosis is 60.) The American Cancer Society says about 90 percent of women with uterine cancer have abnormal bleeding. […] And when we say bleeding, I’ve started adding other words like spotting, discharge or staining, Mueller says. It doesn’t need to be a lot of blood, she says the smallest amount, a spot even, should prompt you to check in with your doctor. Any kind of discharge that’s abnormal is a huge red flag, Mueller says.

• #6 Endometrial Cancer – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK525981/

  Irregular uterine bleeding associated with EIN and cancer can affect women of all ages, becoming more prevalent during the fifth decade of life, especially in women older than 45 years. […] Therefore, all women who are postmenopausal or women 45 and older with AUB should undergo diagnostic endometrial evaluation. […] However, endometrial cancer can also be found in premenopausal women, particularly individuals with risk factors for endometrial hyperplasia. […] Approximately 75% of women diagnosed with endometrial cancer younger than 25 years also had a body mass index greater than 30. […] Therefore, any premenopausal woman with AUB and risk factors for endometrial cancer (eg, Lynch syndrome), exposure to unopposed estrogen (eg, obesity, exogenous estrogen, and polycystic ovarian syndrome), or persistent or recurrent AUB should prompt endometrial assessment to exclude hyperplasia, malignancy, and other differential diagnoses. […] Less frequent endometrial cancer symptoms include abnormal vaginal discharge, pelvic pain, constipation, or diarrhea.

• #7 Endometrial cancer – Symptoms and causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/endometrial-cancer/symptoms-causes/syc-20352461

  Endometrial cancer is often found at an early stage because it causes symptoms. Often the first symptom is irregular vaginal bleeding. […] Symptoms of endometrial cancer may include: Vaginal bleeding after menopause. […] If endometrial cancer is found early, surgically removing the uterus often cures it. […] Bleeding between periods. […] Pelvic pain.

• #8 Uterine Cancer (Endometrial Cancer): Symptoms & Treatment

  https://my.clevelandclinic.org/health/diseases/16409-uterine-cancer

  Uterine cancer symptoms include bleeding between periods or after menopause. […] Signs of uterine cancer can resemble those of many conditions. […] Symptoms of endometrial cancer or uterine sarcoma include: Vaginal bleeding between periods before menopause. Vaginal bleeding or spotting after menopause, even a slight amount. Lower abdominal pain or cramping in your pelvis, just below your belly. Thin white or clear vaginal discharge if you’re postmenopausal. Extremely prolonged, heavy or frequent vaginal bleeding if you’re older than 40. […] The five-year survival rate for endometrial cancer is 81%. […] Fortunately, endometrial cancer is often diagnosed at an early stage. That’s because many people notice unusual bleeding and tell their healthcare providers. If cancer gets caught early and hasn’t spread to other organs, removing your uterus can cure it.

• #9 Endometrial (Uterine) Cancer | Kaiser Permanente

  https://healthy.kaiserpermanente.org/health-wellness/health-encyclopedia/he.endometrial-uterine-cancer.tm6524

  Abnormal or unexpected bleeding from the vagina is the most common symptom of endometrial cancer. […] Symptoms of more advanced endometrial cancer include pain or a lump in the pelvic area and weight loss. […] Symptoms of more advanced endometrial cancer include: Pain in the pelvic area. A pelvic lump. Weight loss. […] When endometrial cancer comes back after treatment, you will probably have symptoms. These include: Bleeding from the vagina, bladder, or rectum. Decreased appetite. Weight loss. Pain in your belly, hip, or back. Cough. Shortness of breath. Swelling in your belly or legs. […] Normally, the lining of the uterus (endometrium) builds up and then sheds with each menstrual cycle. But in most cases of endometrial cancer, the endometrium has built up and has not shed and thinned. The lining has remained thick. This is called endometrial hyperplasia. If not treated, the lining cells can grow quickly and become cancer cells.

• #10 Endometrial Cancer: Signs, Symptoms, and Complications

  https://www.verywellhealth.com/endometrial-cancer-symptoms-514526

  Endometrial cancer involves the endometrium, the tissue that lines the uterus, and is by far the most frequently diagnosed type of uterine cancer. The most common symptom of endometrial cancer is abnormal vaginal bleeding, which includes bleeding after menopause, changes in bleeding before menopause, and bleeding in between periods. Other symptoms can include pain during sex, pelvic pain, abnormal discharge, and fatigue. […] In general terms, the most common symptom of endometrial cancer is abnormal vaginal bleeding. Approximatley 90 percent of women have this symptom, according to the American Cancer Society. […] Any vaginal bleeding or spotting that starts a year or more after you’ve gone through menopause is considered abnormal and requires an evaluation by your healthcare provider.

• #11 Closer Look at Postmenopausal Bleeding and Endometrial Cancer – NCI

  https://www.cancer.gov/news-events/cancer-currents-blog/2018/endometrial-cancer-bleeding-common-symptom

  Women experiencing abnormal vaginal bleeding may undergo a transvaginal ultrasound, biopsy, or both, to determine if an endometrial tumor is the cause. […] 90% of women diagnosed with endometrial cancer reported bleeding before their cancer diagnosis. Approximately 9% of postmenopausal women who saw a doctor for bleeding later received a diagnosis of endometrial cancer. […] Typically, postmenopausal women who experience bleeding are referred for further testing to either rule out or diagnose endometrial cancer. While vaginal bleeding has been known to be a symptom of endometrial cancer, this large study confirms the practice of referring women for further testing. […] The findings confirm that „postmenopausal women with [vaginal] bleeding have a low risk of endometrial cancer, but the vast majority of women with endometrial cancer present with bleeding. […] women should know that getting tested if they have postmenopausal bleeding „gives us an opportunity to [potentially] detect endometrial cancer early, which provides a high likelihood of cure.

• #12 ‘How I knew I had endometrial (uterine) cancer’: Six survivors share symptoms  | MD Anderson Cancer Center

  https://www.mdanderson.org/cancerwise/-how-i-knew-i-had-endometrial-cancer—six-survivors-share-their-symptoms-stories.h00-159621801.html

  Maria Lozano was already well into menopause when she started experiencing the most common symptom of endometrial cancer (also known as uterine cancer): abnormal vaginal bleeding. […] After 10 years of not having my period, suddenly I was bleeding again, says Maria, who was 59 at the time of her stage III endometrial cancer diagnosis. […] Post-menopausal bleeding is actually a wonderful signal the body gives us that something is not right, explains gynecologic oncologist Larissa Meyer, M.D. While not all postmenopausal bleeding is due to cancer, 90% of women with postmenopausal endometrial cancer experienced abnormal vaginal bleeding. […] Vaginal bleeding after menopause is a sentinel sign of endometrial cancer that drives many people to see the doctor, she adds. […] Abnormal vaginal bleeding is such a common symptom of endometrial cancer that it occurs in much younger women, too.

• #13 Warning Signs of Endometrial Cancer » Professor Andreas Obermair

  https://www.obermair.info/latest-news/blog/warning-signs-of-endometrial-cancer/

  Also known as uterine cancer, endometrial cancer begins from abnormal cells at the inner lining of the uterus (called the endometrium). […] There is no screening test for endometrial cancer, but there are signs and symptoms that appear early on in the development of endometrial cancer that should alert women. […] Early warning signs of endometrial cancer can include: Bloody, smelly or watery vaginal discharge, Bleeding between periods (spotting), Unusually heavy periods, Vaginal bleeding after menopause, Discomfort or pain in the abdomen, Difficulty or pain urinating, Unexplained weight loss, Pain during intercourse. […] If you have one or more of these symptoms you should speak to a doctor as soon as possible. […] The most common symptom of endometrial cancer is abnormal vaginal bleeding, particularly any bleeding after menopause is a sign of a problem. Endometrial cancer predominately affects post-menopausal women. In postmenopausal women, even one episode of bleeding (or even a streak of blood) is abnormal for women after menopause and needs to be investigated. All postmenopausal women who present to a GP with vaginal bleeding should be referred to a gynaecologist.

• #14 Signs of Endometrial Cancer You Shouldn’t Ignore » Professor Andreas Obermair

  https://www.obermair.info/latest-news/blog/from-bleeding-to-bloating-signs-of-endometrial-cancer-you-shouldnt-ignore/

  Endometrial cancer, which originates from the inner lining of the uterus (endometrium), can be challenging to detect early as its symptoms may be subtle or easily attributed to other conditions. Understanding the signs and symptoms of endometrial cancer is crucial for early diagnosis and effective treatment. […] […] Postmenopausal Bleeding: Any vaginal bleeding after menopause should be evaluated promptly. This includes spotting or any discharge. […] […] Irregular Menstrual Cycles: For women still menstruating, abnormal bleeding, such as bleeding between periods or unusually heavy periods, can be a sign. […] […] Pelvic Pain or Discomfort: Persistent pelvic pain, discomfort, or a feeling of fullness in the pelvic area can indicate endometrial cancer. This pain may be constant or intermittent. […]

• #15 Endometrial cancer – symptoms, diagnosis and treatment | healthdirect

  https://www.healthdirect.gov.au/endometrial-cancer

  Endometrial cancer occurs when the cells lining the uterus (endometrium) grow in an abnormal and uncontrolled way. The most common symptom of endometrial cancer is abnormal vaginal bleeding. Other symptoms include watery vaginal discharge, unexplained weight loss, difficulty urinating and abdominal (tummy) pain. If you have abnormal or unexpected vaginal bleeding, see your doctor so they can check the cause and make a diagnosis. […] A common early symptom of endometrial cancer is abnormal vaginal bleeding, especially bleeding after menopause. If you are still having your period other symptoms include, bleeding between periods, constant bleeding, or a change in your periods including heavier periods. Other symptoms include: a watery vaginal discharge (this may have an unpleasant smell), unexplained weight loss, difficulty urinating (weeing), a change in bowel (pooing) habits, abdominal (tummy) pain. If you have one or more of these symptoms, it doesn’t necessarily mean you have endometrial cancer. These symptoms can occur for many other reasons. However, it’s important to see a doctor to check. […] If you notice any of the symptoms of endometrial cancer including abnormal vaginal bleeding, it is important to see your doctor. These symptoms are common and don’t necessarily mean you have cancer. However, it’s best to have it checked.

• #16 Uterine Cancer Symptoms | Roswell Park Comprehensive Cancer Center – Buffalo, NY

  https://www.roswellpark.org/cancer/uterine-endometrial/what-uterine-cancer/signs-symptoms

  Many uterine cancers are diagnosed because women report abnormal or post-menopausal bleeding to their physicians. This sign can be a lifesaver, allowing the cancer to be detected in its earliest, most treatable stages. […] The kind of bleeding associated with uterine cancer may start as a watery, blood-streaked flow that gradually contains more blood. Women should not assume that abnormal vaginal bleeding is part of menopause. […] Be sure to tell your physician about any unusual or troubling gynecological symptoms, including: […] Abnormal vaginal bleeding. This includes bleeding or spotting between periods or an unusual discharge with or without blood. […] Vaginal bleeding after menopause […] Difficulty emptying your bladder […] Pain with urination […] Pain during sex […] Pelvic pain. […] While these symptoms dont always mean cancer and a non-cancerous condition or infection may be causing them, prompt diagnosis and treatment is important.

• #17 ‘How I knew I had endometrial (uterine) cancer’: Six survivors share symptoms  | MD Anderson Cancer Center

  https://www.mdanderson.org/cancerwise/-how-i-knew-i-had-endometrial-cancer—six-survivors-share-their-symptoms-stories.h00-159621801.html

  Not everyone with abnormal vaginal bleeding will be diagnosed with endometrial cancer. But other symptoms of this disease include pelvic pain, unexplained weight loss, and abnormal vaginal discharge. […] Moina Faruqui experienced the last symptom on that list for about three months before she was diagnosed with stage IV endometrial cancer at age 65. […] So, the bottom line is that if you have concerns about your cycle, or if you think you’re experiencing abnormal bleeding or any other symptom of endometrial cancer, talk to your gynecologist, she says. And, if you’re already in menopause and start bleeding again, get checked out. Because that’s not normal. Periods don’t just suddenly start up again years after they’ve stopped.

• #18 Endometrial Cancer Associated Symptoms: A Case-Control Study

  https://pmc.ncbi.nlm.nih.gov/articles/PMC5116765/

  The majority of women with endometrial cancer (EC) present at an early stage with an associated 5-year survival rate of 90%. High rates of early detection are attributed to warning symptoms; however, the prevalence of such symptoms has not been well defined. […] The cases were more likely to report postmenopausal bleeding (OR=32.99 and 5.83, p0.01) and abnormal vaginal discharge (OR=8.8 and 3.3, p0.01) compared with the AV and PV groups. Overall, 55.4% of cases reported abnormal vaginal discharge. […] Symptoms of both postmenopausal bleeding and abnormal vaginal discharge were significantly higher in EC compared with controls. The presence of such symptoms should raise concern for malignant disease and prompt immediate gynecological evaluation. […] The presence of postmenopausal bleeding was predictive of EC with an OR of 32.99 in cases compared with healthy patients seen for AV and an OR of 5.83 compared with patients seen for a PV. Abnormal vaginal discharge was also strongly associated with EC, and reported in 55.4% of all EC cases with an OR of 8.80 compared with AV controls and an OR of 3.30 compared with PV controls.

• #19 Signs of Endometrial Cancer You Shouldn’t Ignore » Professor Andreas Obermair

  https://www.obermair.info/latest-news/blog/from-bleeding-to-bloating-signs-of-endometrial-cancer-you-shouldnt-ignore/

  Abnormal Vaginal Discharge: Unusual Discharge: A watery, pink, or blood-streaked discharge from the vagina that is not related to menstruation can be a symptom of endometrial cancer. […] […] Unexplained Weight Loss: Significant and unexplained weight loss can be a symptom of various cancers, including endometrial cancer. Its important to consider this in the context of other symptoms. […] […] Abdominal Swelling or Bloating: Persistent abdominal swelling or bloating, especially when combined with other symptoms, should be assessed by your GP. […] […] Frequent Urination: An increased urge to urinate or difficulty emptying the bladder fully can sometimes be associated with endometrial cancer. […] […] Persistent Fatigue: While fatigue can be caused by many conditions, persistent and unexplained fatigue should be evaluated, especially if accompanied by other symptoms. […] […] If you experience any of these symptoms, particularly if they are new or worsening, it is essential to see your GP in the first instance. Early evaluation is crucial for determining the cause and initiating appropriate treatment.

• #20 Endometrial cancer – symptoms, diagnosis and treatment | healthdirect

  https://www.healthdirect.gov.au/endometrial-cancer

  Endometrial cancer occurs when the cells lining the uterus (endometrium) grow in an abnormal and uncontrolled way. The most common symptom of endometrial cancer is abnormal vaginal bleeding. Other symptoms include watery vaginal discharge, unexplained weight loss, difficulty urinating and abdominal (tummy) pain. If you have abnormal or unexpected vaginal bleeding, see your doctor so they can check the cause and make a diagnosis. […] A common early symptom of endometrial cancer is abnormal vaginal bleeding, especially bleeding after menopause. If you are still having your period other symptoms include, bleeding between periods, constant bleeding, or a change in your periods including heavier periods. Other symptoms include: a watery vaginal discharge (this may have an unpleasant smell), unexplained weight loss, difficulty urinating (weeing), a change in bowel (pooing) habits, abdominal (tummy) pain. If you have one or more of these symptoms, it doesn’t necessarily mean you have endometrial cancer. These symptoms can occur for many other reasons. However, it’s important to see a doctor to check. […] If you notice any of the symptoms of endometrial cancer including abnormal vaginal bleeding, it is important to see your doctor. These symptoms are common and don’t necessarily mean you have cancer. However, it’s best to have it checked.

• #21 Endometrial Cancer | Uterine Cancer | University of Michigan Rogel Cancer Center

  https://www.rogelcancercenter.org/gynecologic-cancers/endometrial-uterine

  Unusual vaginal bleeding, spotting, or other discharge. About 90% of patients diagnosed with endometrial cancer have abnormal vaginal bleeding, such as a change in their periods or bleeding between periods or after menopause. This symptom can also occur with some non-cancerous conditions, so if you notice this, be sure to report this to your doctor as soon as possible. If you have gone through menopause, it is especially important to report any vaginal bleeding, spotting, or abnormal discharge to your doctor. […] Non-bloody vaginal discharge. If you notice a change in the frequency or amount of discharge you experience throughout the month, it is important to report this change to your doctor as it may be a sign of endometrial cancer. In about 10% of cases, the discharge associated with endometrial cancer is not bloody. Any abnormal discharge should be evaluated by your doctor. […] Pelvic pain and/or mass and weight loss. Pain in the pelvis, feeling a mass or lump in your pelvic area and/or losing weight without trying can also be symptoms of endometrial cancer. These symptoms are more common later if the cancer has spread beyond the uterus.

• #22 Uterine (Endometrial) Cancer Stages

  https://www.webmd.com/cancer/cervical-cancer/uterine-cancer-stages

  Endometrial cancer often begins in the uterine lining. It’s also called uterine cancer. It’s the most common female reproductive cancer. In fact, uterine cancer is the fourth most common cancer for women in the U.S. […] Although there are many types of uterine cancer, most are endometrial. It starts in the inner lining of your uterus. […] The most common symptom is bleeding that isn’t normal. That can mean spotting or bleeding between your menstrual periods. You may also have watery or blood-tinged discharge from your vagina. […] If you’ve gone through menopause, any vaginal bleeding can be a symptom. Typically, uterine cancer is diagnosed around 60 years of age. So its unusual to menstruate at this stage in life. […] Keep in mind that not everyone has bloody discharge. Sometimes, non-bloody vaginal discharge can signal uterine cancer, too.

• #23 Endometrial Cancer | Uterine Cancer | University of Michigan Rogel Cancer Center

  https://www.rogelcancercenter.org/gynecologic-cancers/endometrial-uterine

  Unusual vaginal bleeding, spotting, or other discharge. About 90% of patients diagnosed with endometrial cancer have abnormal vaginal bleeding, such as a change in their periods or bleeding between periods or after menopause. This symptom can also occur with some non-cancerous conditions, so if you notice this, be sure to report this to your doctor as soon as possible. If you have gone through menopause, it is especially important to report any vaginal bleeding, spotting, or abnormal discharge to your doctor. […] Non-bloody vaginal discharge. If you notice a change in the frequency or amount of discharge you experience throughout the month, it is important to report this change to your doctor as it may be a sign of endometrial cancer. In about 10% of cases, the discharge associated with endometrial cancer is not bloody. Any abnormal discharge should be evaluated by your doctor. […] Pelvic pain and/or mass and weight loss. Pain in the pelvis, feeling a mass or lump in your pelvic area and/or losing weight without trying can also be symptoms of endometrial cancer. These symptoms are more common later if the cancer has spread beyond the uterus.

• #24 Endometrial cancer – Symptoms and causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/endometrial-cancer/symptoms-causes/syc-20352461

  Endometrial cancer is often found at an early stage because it causes symptoms. Often the first symptom is irregular vaginal bleeding. […] Symptoms of endometrial cancer may include: Vaginal bleeding after menopause. […] If endometrial cancer is found early, surgically removing the uterus often cures it. […] Bleeding between periods. […] Pelvic pain.

• #25 Signs of Endometrial Cancer You Shouldn’t Ignore » Professor Andreas Obermair

  https://www.obermair.info/latest-news/blog/from-bleeding-to-bloating-signs-of-endometrial-cancer-you-shouldnt-ignore/

  Endometrial cancer, which originates from the inner lining of the uterus (endometrium), can be challenging to detect early as its symptoms may be subtle or easily attributed to other conditions. Understanding the signs and symptoms of endometrial cancer is crucial for early diagnosis and effective treatment. […] […] Postmenopausal Bleeding: Any vaginal bleeding after menopause should be evaluated promptly. This includes spotting or any discharge. […] […] Irregular Menstrual Cycles: For women still menstruating, abnormal bleeding, such as bleeding between periods or unusually heavy periods, can be a sign. […] […] Pelvic Pain or Discomfort: Persistent pelvic pain, discomfort, or a feeling of fullness in the pelvic area can indicate endometrial cancer. This pain may be constant or intermittent. […]

• #26 Uterine (Endometrial) Cancer Stages

  https://www.webmd.com/cancer/cervical-cancer/uterine-cancer-stages

  You’ll commonly get unusual bleeding, spotting, or discharge. But not seeing blood doesn’t rule out cancer. If you have an unusual discharge, talk to your doctor. They can help you figure out what may be going on. […] As the tumor grows and spreads, it can put pressure on other organs or blood vessels. With uterine cancer you may have: Unusual vaginal bleeding or discharge, Pelvic or belly pain, Bloating or feel full, Pain during sex, A full feeling when eating, Changes in your bowel or bladder habits, Weight loss without trying, A lump or feel the tumor in your belly. […] You can get any of the symptoms of stages 1 to 3 like bloody or unusual discharge. You can have pelvic pain, bloating, or pain during sex. You may feel full quickly when eating or feel a lump in your belly. You can also get changes in your bowel habits or lose weight. […] Bleeding can happen at any stage of uterine cancer. If you notice any unusual spotting or bleeding, see your doctor or get medical help.

• #27 Signs and Symptoms of Uterine Cancer | Mount Sinai – New York

  https://www.mountsinai.org/care/cancer/services/gynecologic/conditions/uterine/symptoms

  Most women who have endometrial cancer experience abnormal vaginal bleeding—out of sync with your menstrual cycle or after you have gone through menopause. […] See your gynecologist for an accurate diagnosis if you experience any of these endometrial (uterine) cancer symptoms: […] Having these symptoms or learning that that you may be at risk for uterine cancer — even without symptoms — indicates that it is time to see a gynecologic oncologist.

• #28 Uterine (Endometrial) Cancer Stages

  https://www.webmd.com/uterine-cancer/uterine-cancer-stages

  As the tumor grows and spreads, it can put pressure on other organs or blood vessels. With uterine cancer you may have: Unusual vaginal bleeding or discharge, Pelvic or belly pain, Bloating or feel full, Pain during sex, A full feeling when eating, Changes in your bowel or bladder habits, Weight loss without trying, A lump or feel the tumor in your belly. […] You can get any of the symptoms of stages 1 to 3 like bloody or unusual discharge. You can have pelvic pain, bloating, or pain during sex. You may feel full quickly when eating or feel a lump in your belly. You can also get changes in your bowel habits or lose weight. […] Bleeding can happen at any stage of uterine cancer. If you notice any unusual spotting or bleeding, see your doctor or get medical help.

• #29 Recognizing Symptoms of Advanced Uterine Cancer

  https://www.healthline.com/health/advanced-uterine-cancer-symptoms

  Uterine cancer may not exhibit any symptoms in the early stages. So, if you do develop symptoms like pelvic pain, abnormal uterine bleeding, or unexplained weight loss, see your doctor right away for a diagnosis. […] Because theres no screening test for uterine cancer like the Pap test used to screen for cervical cancer, its important to become familiar with the symptoms. You may not experience any symptoms in the earliest stage. […] If you do begin to have symptoms that could be symptoms of uterine cancer, contact your doctor immediately. […] The most common symptom of endometrial cancer is abnormal uterine bleeding, which can occur during the early stages or later stages. […] Pelvic pain is a symptom of uterine cancer. And persistent pain in your lower abdomen or cramping could be a sign of uterine cancer that has spread. In fact, the American Cancer Society notes that pelvic pain is more common in the later stages of the disease.

• #30 Signs of Endometrial Cancer You Shouldn’t Ignore » Professor Andreas Obermair

  https://www.obermair.info/latest-news/blog/from-bleeding-to-bloating-signs-of-endometrial-cancer-you-shouldnt-ignore/

  Abnormal Vaginal Discharge: Unusual Discharge: A watery, pink, or blood-streaked discharge from the vagina that is not related to menstruation can be a symptom of endometrial cancer. […] […] Unexplained Weight Loss: Significant and unexplained weight loss can be a symptom of various cancers, including endometrial cancer. Its important to consider this in the context of other symptoms. […] […] Abdominal Swelling or Bloating: Persistent abdominal swelling or bloating, especially when combined with other symptoms, should be assessed by your GP. […] […] Frequent Urination: An increased urge to urinate or difficulty emptying the bladder fully can sometimes be associated with endometrial cancer. […] […] Persistent Fatigue: While fatigue can be caused by many conditions, persistent and unexplained fatigue should be evaluated, especially if accompanied by other symptoms. […] […] If you experience any of these symptoms, particularly if they are new or worsening, it is essential to see your GP in the first instance. Early evaluation is crucial for determining the cause and initiating appropriate treatment.

• #31 Uterine Cancer Symptoms | Roswell Park Comprehensive Cancer Center – Buffalo, NY

  https://www.roswellpark.org/cancer/uterine-endometrial/what-uterine-cancer/signs-symptoms

  Many uterine cancers are diagnosed because women report abnormal or post-menopausal bleeding to their physicians. This sign can be a lifesaver, allowing the cancer to be detected in its earliest, most treatable stages. […] The kind of bleeding associated with uterine cancer may start as a watery, blood-streaked flow that gradually contains more blood. Women should not assume that abnormal vaginal bleeding is part of menopause. […] Be sure to tell your physician about any unusual or troubling gynecological symptoms, including: […] Abnormal vaginal bleeding. This includes bleeding or spotting between periods or an unusual discharge with or without blood. […] Vaginal bleeding after menopause […] Difficulty emptying your bladder […] Pain with urination […] Pain during sex […] Pelvic pain. […] While these symptoms dont always mean cancer and a non-cancerous condition or infection may be causing them, prompt diagnosis and treatment is important.

• #32 Signs of Endometrial Cancer You Shouldn’t Ignore » Professor Andreas Obermair

  https://www.obermair.info/latest-news/blog/from-bleeding-to-bloating-signs-of-endometrial-cancer-you-shouldnt-ignore/

  Abnormal Vaginal Discharge: Unusual Discharge: A watery, pink, or blood-streaked discharge from the vagina that is not related to menstruation can be a symptom of endometrial cancer. […] […] Unexplained Weight Loss: Significant and unexplained weight loss can be a symptom of various cancers, including endometrial cancer. Its important to consider this in the context of other symptoms. […] […] Abdominal Swelling or Bloating: Persistent abdominal swelling or bloating, especially when combined with other symptoms, should be assessed by your GP. […] […] Frequent Urination: An increased urge to urinate or difficulty emptying the bladder fully can sometimes be associated with endometrial cancer. […] […] Persistent Fatigue: While fatigue can be caused by many conditions, persistent and unexplained fatigue should be evaluated, especially if accompanied by other symptoms. […] […] If you experience any of these symptoms, particularly if they are new or worsening, it is essential to see your GP in the first instance. Early evaluation is crucial for determining the cause and initiating appropriate treatment.

• #33 Symptoms Of Womb Cancer | Cancer research UK

  https://www.cancerresearchuk.org/about-cancer/womb-cancer/symptoms

  Womb cancer is sometimes called endometrial cancer. The most common symptom of womb cancer is abnormal bleeding from the vagina. This is especially in women who have stopped having periods (post menopausal women). […] Symptoms of womb cancer can include: bleeding after the menopause, bleeding that is unusually heavy or persistent between periods, an abnormal vaginal discharge that might be pink. […] Less common symptoms of womb cancer include blood in the urine (haematuria) with either a low red blood cell level (anaemia), high platelet count (thrombocytosis), or high blood sugar level. […] Other symptoms of womb cancer may include: tummy (abdominal) pain, a swollen tummy, bloating, a change in bowel or bladder habits, a new cough. […] If you have any of these symptoms, you must get them checked by your GP. But remember, they can all be caused by other conditions. Most people with these symptoms don’t have womb cancer.

• #34 7 Symptoms of Stage 4 Endometrial Cancer | MyEndometrialCancerTeam

  https://www.myendometrialcancerteam.com/resources/symptoms-of-stage-4-endometrial-cancer

  Painful urination is a common stage 4 endometrial cancer symptom, but the urinary symptoms don’t stop there. […] Your bowel habits can also change during stage 4 endometrial cancer, which might indicate that the cancer has spread to your intestine. […] If stage 4B endometrial cancer spreads to the lungs, you might experience trouble breathing. […] Fatigue is a common symptom of many cancers, even in their early stages. Extreme tiredness can also be a sign that stage 4 endometrial cancer has spread into your liver.

• #35 Uterine (Endometrial) Cancer Stages

  https://www.webmd.com/uterine-cancer/uterine-cancer-stages

  As the tumor grows and spreads, it can put pressure on other organs or blood vessels. With uterine cancer you may have: Unusual vaginal bleeding or discharge, Pelvic or belly pain, Bloating or feel full, Pain during sex, A full feeling when eating, Changes in your bowel or bladder habits, Weight loss without trying, A lump or feel the tumor in your belly. […] You can get any of the symptoms of stages 1 to 3 like bloody or unusual discharge. You can have pelvic pain, bloating, or pain during sex. You may feel full quickly when eating or feel a lump in your belly. You can also get changes in your bowel habits or lose weight. […] Bleeding can happen at any stage of uterine cancer. If you notice any unusual spotting or bleeding, see your doctor or get medical help.

• #36 Uterine (Endometrial) Cancer Stages

  https://www.webmd.com/uterine-cancer/uterine-cancer-stages

  As the tumor grows and spreads, it can put pressure on other organs or blood vessels. With uterine cancer you may have: Unusual vaginal bleeding or discharge, Pelvic or belly pain, Bloating or feel full, Pain during sex, A full feeling when eating, Changes in your bowel or bladder habits, Weight loss without trying, A lump or feel the tumor in your belly. […] You can get any of the symptoms of stages 1 to 3 like bloody or unusual discharge. You can have pelvic pain, bloating, or pain during sex. You may feel full quickly when eating or feel a lump in your belly. You can also get changes in your bowel habits or lose weight. […] Bleeding can happen at any stage of uterine cancer. If you notice any unusual spotting or bleeding, see your doctor or get medical help.

• #37 Signs of Endometrial Cancer You Shouldn’t Ignore » Professor Andreas Obermair

  https://www.obermair.info/latest-news/blog/from-bleeding-to-bloating-signs-of-endometrial-cancer-you-shouldnt-ignore/

  Abnormal Vaginal Discharge: Unusual Discharge: A watery, pink, or blood-streaked discharge from the vagina that is not related to menstruation can be a symptom of endometrial cancer. […] […] Unexplained Weight Loss: Significant and unexplained weight loss can be a symptom of various cancers, including endometrial cancer. Its important to consider this in the context of other symptoms. […] […] Abdominal Swelling or Bloating: Persistent abdominal swelling or bloating, especially when combined with other symptoms, should be assessed by your GP. […] […] Frequent Urination: An increased urge to urinate or difficulty emptying the bladder fully can sometimes be associated with endometrial cancer. […] […] Persistent Fatigue: While fatigue can be caused by many conditions, persistent and unexplained fatigue should be evaluated, especially if accompanied by other symptoms. […] […] If you experience any of these symptoms, particularly if they are new or worsening, it is essential to see your GP in the first instance. Early evaluation is crucial for determining the cause and initiating appropriate treatment.

• #38 Symptoms of uterine cancer | Canadian Cancer Society

  https://cancer.ca/en/cancer-information/cancer-types/uterine/signs-and-symptoms

  Uterine cancer can cause different signs and symptoms as the cancer grows. Other health conditions can cause the same symptoms as uterine cancer. […] The most common symptom of uterine cancer is abnormal vaginal bleeding. This includes a change in menstruation (heavier periods, periods that last longer or periods that occur more often than normal), bleeding between periods, bleeding after menopause or spotting. […] Other signs and symptoms of uterine cancer include: unusual vaginal discharge, which can be foul-smelling, pus-like or blood-tinged; pain during intercourse; pelvic pain or pressure; pain or feeling of pressure in the pelvis, lower abdomen, back or legs; pain during urination, difficult urination or blood in the urine; pain during bowel movements, difficult bowel movements or blood in the stool; bleeding from the bladder or rectum; buildup of fluid in the abdomen (called ascites) or in the legs (called lymphedema); weight loss; lack of appetite; difficulty breathing.

• #39 7 Symptoms of Stage 4 Endometrial Cancer | MyEndometrialCancerTeam

  https://www.myendometrialcancerteam.com/resources/symptoms-of-stage-4-endometrial-cancer

  Part of getting an endometrial cancer diagnosis is finding out which stage of endometrial cancer you have. Stage 4 endometrial cancer means the cancer has spread from the inner lining of the uterus to other parts of the body, often other pelvic organs like your bladder or bowel. The further endometrial cancer progresses, the more likely you are to notice symptoms. […] The symptoms of stage 4 endometrial cancer depend on how far the cancer has spread and which areas it has spread into. […] Vaginal bleeding between periods or after menopause is the most common endometrial cancer symptom at any stage. […] Losing weight when you’re not trying to lose weight may be a sign of stage 4 endometrial cancer. […] Pelvic pain, pressure, and cramping can be a sign of stage 4 endometrial cancer. […] If endometrial cancer spreads to the bowel, you may notice symptoms like constipation, incontinence, or abdominal pain.

• #40 Recognizing Symptoms of Advanced Uterine Cancer

  https://www.healthline.com/health/advanced-uterine-cancer-symptoms

  Unexplained weight loss might be cause for concern. This is another symptom thats common in the later stages of the disease. […] Another possible symptom of uterine cancer that has spread is weakness and pain in the lower abdomen and possibly even the lower back and legs. […] Its possible that you might experience other symptoms, too. This might include pain during sexual intercourse, painful urination, frequent urination, anemia, feeling a mass in the abdomen. […] Currently, the 5-year survival rate for uterine cancer is 81%. As with many other cancers, early detection and prompt treatment are key to ensuring better outcomes, including a longer life.

• #41 Signs of Endometrial Cancer You Shouldn’t Ignore » Professor Andreas Obermair

  https://www.obermair.info/latest-news/blog/from-bleeding-to-bloating-signs-of-endometrial-cancer-you-shouldnt-ignore/

  Abnormal Vaginal Discharge: Unusual Discharge: A watery, pink, or blood-streaked discharge from the vagina that is not related to menstruation can be a symptom of endometrial cancer. […] […] Unexplained Weight Loss: Significant and unexplained weight loss can be a symptom of various cancers, including endometrial cancer. Its important to consider this in the context of other symptoms. […] […] Abdominal Swelling or Bloating: Persistent abdominal swelling or bloating, especially when combined with other symptoms, should be assessed by your GP. […] […] Frequent Urination: An increased urge to urinate or difficulty emptying the bladder fully can sometimes be associated with endometrial cancer. […] […] Persistent Fatigue: While fatigue can be caused by many conditions, persistent and unexplained fatigue should be evaluated, especially if accompanied by other symptoms. […] […] If you experience any of these symptoms, particularly if they are new or worsening, it is essential to see your GP in the first instance. Early evaluation is crucial for determining the cause and initiating appropriate treatment.

• #42

  https://www.prevention.com/health/g20505789/5-signs-of-endometrial-cancer/

  Changes in your bathroom habits […] Does pressure in your pelvis have you heading for the ladies’ room more often? Your bladder and bowels can be a good indicator of uterine problems, and that includes cancer. Cancer might make you need to go more often, have trouble getting urine out, or cause pain when you do go. You might also notice blood in your bowel movements, or it may hurt when you try to pass stool. […] Dropping pounds for no reason […] If you’re experiencing this symptom, it may mean your body’s been dealing with a problem for a long time. „Weight loss is rare unless it’s more advanced cancer,” says Lee. If the numbers are plummeting every time you step on a scale, especially if you have other gynecological symptoms, see your doctor ASAP.

• #43 Signs of Endometrial Cancer You Shouldn’t Ignore » Professor Andreas Obermair

  https://www.obermair.info/latest-news/blog/from-bleeding-to-bloating-signs-of-endometrial-cancer-you-shouldnt-ignore/

  Abnormal Vaginal Discharge: Unusual Discharge: A watery, pink, or blood-streaked discharge from the vagina that is not related to menstruation can be a symptom of endometrial cancer. […] […] Unexplained Weight Loss: Significant and unexplained weight loss can be a symptom of various cancers, including endometrial cancer. Its important to consider this in the context of other symptoms. […] […] Abdominal Swelling or Bloating: Persistent abdominal swelling or bloating, especially when combined with other symptoms, should be assessed by your GP. […] […] Frequent Urination: An increased urge to urinate or difficulty emptying the bladder fully can sometimes be associated with endometrial cancer. […] […] Persistent Fatigue: While fatigue can be caused by many conditions, persistent and unexplained fatigue should be evaluated, especially if accompanied by other symptoms. […] […] If you experience any of these symptoms, particularly if they are new or worsening, it is essential to see your GP in the first instance. Early evaluation is crucial for determining the cause and initiating appropriate treatment.

• #44 Endometrial Cancer Symptoms | YourCareEverywhere

  https://yourcareeverywhere.com/health-research/health-insights/cancer-care-insights/endometrial-cancer-symptoms.html

  Abnormal bleeding is the warning sign that endometrial cancer cells may have begun to grow out of control in the inner lining of your uterus. […] The tell-tale symptom is abnormal bleeding. You might have heavy bleeding in between periods, or you might bleed after menopause. […] Other symptoms include pelvic pain. You might have pain during sex. […] Unexplained weight loss can be a symptom of endometrial cancer. Losing 10 or more pounds unintentionally may mean that your body is working hard to fight off tumor cells. […] Unexplained fatigue is also worth evaluation. If your weeks haven’t been especially busy and you’ve had your usual amount of sleep, ongoing fatigue could be a sign that your body is fighting a tumor. […] Your abdomen may stick out. You also might have symptoms associated with irritable bowel syndrome, such as diarrhea or constipation as well as bloating.

• #45 7 Symptoms of Stage 4 Endometrial Cancer | MyEndometrialCancerTeam

  https://www.myendometrialcancerteam.com/resources/symptoms-of-stage-4-endometrial-cancer

  Painful urination is a common stage 4 endometrial cancer symptom, but the urinary symptoms don’t stop there. […] Your bowel habits can also change during stage 4 endometrial cancer, which might indicate that the cancer has spread to your intestine. […] If stage 4B endometrial cancer spreads to the lungs, you might experience trouble breathing. […] Fatigue is a common symptom of many cancers, even in their early stages. Extreme tiredness can also be a sign that stage 4 endometrial cancer has spread into your liver.

• #46 Uterine (Endometrial) Cancer Stages

  https://www.webmd.com/uterine-cancer/uterine-cancer-stages

  As the tumor grows and spreads, it can put pressure on other organs or blood vessels. With uterine cancer you may have: Unusual vaginal bleeding or discharge, Pelvic or belly pain, Bloating or feel full, Pain during sex, A full feeling when eating, Changes in your bowel or bladder habits, Weight loss without trying, A lump or feel the tumor in your belly. […] You can get any of the symptoms of stages 1 to 3 like bloody or unusual discharge. You can have pelvic pain, bloating, or pain during sex. You may feel full quickly when eating or feel a lump in your belly. You can also get changes in your bowel habits or lose weight. […] Bleeding can happen at any stage of uterine cancer. If you notice any unusual spotting or bleeding, see your doctor or get medical help.

• #47 7 Symptoms of Stage 4 Endometrial Cancer | MyEndometrialCancerTeam

  https://www.myendometrialcancerteam.com/resources/symptoms-of-stage-4-endometrial-cancer

  Painful urination is a common stage 4 endometrial cancer symptom, but the urinary symptoms don’t stop there. […] Your bowel habits can also change during stage 4 endometrial cancer, which might indicate that the cancer has spread to your intestine. […] If stage 4B endometrial cancer spreads to the lungs, you might experience trouble breathing. […] Fatigue is a common symptom of many cancers, even in their early stages. Extreme tiredness can also be a sign that stage 4 endometrial cancer has spread into your liver.

• #48 Symptoms Of Womb Cancer | Cancer research UK

  https://www.cancerresearchuk.org/about-cancer/womb-cancer/symptoms

  Womb cancer is sometimes called endometrial cancer. The most common symptom of womb cancer is abnormal bleeding from the vagina. This is especially in women who have stopped having periods (post menopausal women). […] Symptoms of womb cancer can include: bleeding after the menopause, bleeding that is unusually heavy or persistent between periods, an abnormal vaginal discharge that might be pink. […] Less common symptoms of womb cancer include blood in the urine (haematuria) with either a low red blood cell level (anaemia), high platelet count (thrombocytosis), or high blood sugar level. […] Other symptoms of womb cancer may include: tummy (abdominal) pain, a swollen tummy, bloating, a change in bowel or bladder habits, a new cough. […] If you have any of these symptoms, you must get them checked by your GP. But remember, they can all be caused by other conditions. Most people with these symptoms don’t have womb cancer.

• #49 Leaders in Diagnosing and Treating Uterine Cancer

  https://www.rwjbh.org/treatment-care/cancer/types-of-cancer/gynecologic-cancer/types-of-cancers-we-treat/uterine-cancer/

  More than 90 percent of women with uterine (endometrial) cancer experience abnormal vaginal bleeding. Other symptoms of uterine cancer may include: […] At later, more advanced stages of uterine cancer, common symptoms may include: Pelvic pain […] Weakness and pain in the lower abdomen, back, or legs. This is an indication that the cancer has metastasized (spread) to other bodily organs.

• #50

  https://carle.org/conditions/cancer-conditions/endometrial-cancer

  Bleeding from the vagina after menopause is the main symptom. […] For women who haven’t gone through menopause, abnormal vaginal bleeding—heavy bleeding, minimal bleeding, bleeding between menstrual cycles—is the main symptom. […] Untreated endometrial cancer spreads and causes problems in the pelvic area, including bowel and urinary disorders. If the spread continues, swollen glands (lymph nodes), an abdominal (belly) mass, and eventually liver, lung, and bone disease can result.

• #51 Symptoms of uterine cancer | Canadian Cancer Society

  https://cancer.ca/en/cancer-information/cancer-types/uterine/signs-and-symptoms

  Uterine cancer can cause different signs and symptoms as the cancer grows. Other health conditions can cause the same symptoms as uterine cancer. […] The most common symptom of uterine cancer is abnormal vaginal bleeding. This includes a change in menstruation (heavier periods, periods that last longer or periods that occur more often than normal), bleeding between periods, bleeding after menopause or spotting. […] Other signs and symptoms of uterine cancer include: unusual vaginal discharge, which can be foul-smelling, pus-like or blood-tinged; pain during intercourse; pelvic pain or pressure; pain or feeling of pressure in the pelvis, lower abdomen, back or legs; pain during urination, difficult urination or blood in the urine; pain during bowel movements, difficult bowel movements or blood in the stool; bleeding from the bladder or rectum; buildup of fluid in the abdomen (called ascites) or in the legs (called lymphedema); weight loss; lack of appetite; difficulty breathing.

• #52 Symptoms of uterine cancer | Canadian Cancer Society

  https://cancer.ca/en/cancer-information/cancer-types/uterine/signs-and-symptoms

  Uterine cancer can cause different signs and symptoms as the cancer grows. Other health conditions can cause the same symptoms as uterine cancer. […] The most common symptom of uterine cancer is abnormal vaginal bleeding. This includes a change in menstruation (heavier periods, periods that last longer or periods that occur more often than normal), bleeding between periods, bleeding after menopause or spotting. […] Other signs and symptoms of uterine cancer include: unusual vaginal discharge, which can be foul-smelling, pus-like or blood-tinged; pain during intercourse; pelvic pain or pressure; pain or feeling of pressure in the pelvis, lower abdomen, back or legs; pain during urination, difficult urination or blood in the urine; pain during bowel movements, difficult bowel movements or blood in the stool; bleeding from the bladder or rectum; buildup of fluid in the abdomen (called ascites) or in the legs (called lymphedema); weight loss; lack of appetite; difficulty breathing.

• #53 Endometrial Cancer: Signs, Symptoms, and Complications

  https://www.verywellhealth.com/endometrial-cancer-symptoms-514526

  Other symptoms of endometrial cancer that can occur before or after menopause include: A watery or blood-tinged vaginal discharge, Pain during sexual intercourse. […] Symptoms that may occur in the later stages of cancer include: Pelvic pain or cramping, Abdominal pain, Being able to feel a mass or tumor in your pelvis, Losing weight without trying, Fatigue, Bloating, Changes in bowel or bladder habits, Feeling full quickly. […] Because the symptoms are so non-specific in the early stages, around 30% of cases are diagnosed when the cancer is advanced (stages 3 and 4), typically causing pelvic pain, unintended weight loss, and a perceivable pelvic mass. Even so, the vast majority of cases are diagnosed during the early stages (stages 1 and 2). […] When endometrial cancer spreads (metastasizes), it will most often affect the bladder, rectum, vagina, ovaries, or fallopian tubes. Signs may include frequent or painful urination, pain during intercourse, rectal pain or discharge, and persistent pelvic cramping. There may also be generalized symptoms like fatigue, loss of appetite, and unintended weight loss. […] While abnormal vaginal bleeding, vaginal discharge, pelvic pain, and a palpable mass are the most common signs, other frequent symptoms are urinary frequency or pain, changes in bowel habits, abdominal pain, unintended weight loss, persistent cough, chest pain, and deep vein thrombosis (DVT).

• #54 Uterine (Endometrial) Cancer Stages

  https://www.webmd.com/uterine-cancer/uterine-cancer-stages

  As the tumor grows and spreads, it can put pressure on other organs or blood vessels. With uterine cancer you may have: Unusual vaginal bleeding or discharge, Pelvic or belly pain, Bloating or feel full, Pain during sex, A full feeling when eating, Changes in your bowel or bladder habits, Weight loss without trying, A lump or feel the tumor in your belly. […] You can get any of the symptoms of stages 1 to 3 like bloody or unusual discharge. You can have pelvic pain, bloating, or pain during sex. You may feel full quickly when eating or feel a lump in your belly. You can also get changes in your bowel habits or lose weight. […] Bleeding can happen at any stage of uterine cancer. If you notice any unusual spotting or bleeding, see your doctor or get medical help.

• #55 Endometrial Cancer Symptoms, Diagnosis, and Treatment Options – Ezra

  https://ezra.com/blog/endometrial-cancer-symptoms

  Persistent or intermittent pelvic pain can be an indication of endometrial cancer, especially if it’s a new symptom for the individual. This can include: Dull aches to more severe cramps or pressure in the pelvic area, Painful intercourse, Pain when urinating or difficulty emptying the bladder. […] Sudden, unexplained weight loss can sometimes be a symptom of various types of cancer, including endometrial cancer. […] In advanced stages, the endometrial tumors might cause the uterus or the abdominal area to enlarge. […] Early detection of uterine and endometrial cancer significantly boosts survival rates. When diagnosed at an early stage, where the cancer is confined to the uterus, the chances of successful cancer care and long-term survival are much higher. […] Uncovering endometrial cancer symptoms early often means more treatment options are available, including less invasive surgical procedures and the potential to preserve fertility in younger people.

• #56 Endometrial Cancer: Signs, Symptoms, and Complications

  https://www.verywellhealth.com/endometrial-cancer-symptoms-514526

  Other symptoms of endometrial cancer that can occur before or after menopause include: A watery or blood-tinged vaginal discharge, Pain during sexual intercourse. […] Symptoms that may occur in the later stages of cancer include: Pelvic pain or cramping, Abdominal pain, Being able to feel a mass or tumor in your pelvis, Losing weight without trying, Fatigue, Bloating, Changes in bowel or bladder habits, Feeling full quickly. […] Because the symptoms are so non-specific in the early stages, around 30% of cases are diagnosed when the cancer is advanced (stages 3 and 4), typically causing pelvic pain, unintended weight loss, and a perceivable pelvic mass. Even so, the vast majority of cases are diagnosed during the early stages (stages 1 and 2). […] When endometrial cancer spreads (metastasizes), it will most often affect the bladder, rectum, vagina, ovaries, or fallopian tubes. Signs may include frequent or painful urination, pain during intercourse, rectal pain or discharge, and persistent pelvic cramping. There may also be generalized symptoms like fatigue, loss of appetite, and unintended weight loss. […] While abnormal vaginal bleeding, vaginal discharge, pelvic pain, and a palpable mass are the most common signs, other frequent symptoms are urinary frequency or pain, changes in bowel habits, abdominal pain, unintended weight loss, persistent cough, chest pain, and deep vein thrombosis (DVT).

• #57 What is Endometrial Cancer? Symptoms, Risk Factors & Treatments | MD Anderson Cancer Center

  https://www.mdanderson.org/cancer-types/endometrial-cancer.html

  Endometrial cancer is the most common cancer of the female reproductive organs. It starts in the endometrium, a layer of tissue that lines the interior of the uterus, or womb. […] Most endometrial cancers develop over a period of years. They may start as less serious problems such as endometrial hyperplasia, which is an overgrowth of cells in the lining of the uterus. […] Fortunately, many endometrial cancers are found early because of warning signs such as abnormal or postmenopausal bleeding. If endometrial cancer is found in the earliest stages, it often can be treated successfully.

• #58 Diagnosis and Management of Endometrial Cancer | AAFP

  https://www.aafp.org/pubs/afp/issues/2016/0315/p468.html

  Endometrial cancer is the most common gynecologic malignancy. The most common presentation for endometrial cancer is postmenopausal bleeding. The American Cancer Society recommends that all women older than 65 years be informed of the risks and symptoms of endometrial cancer and advised to seek evaluation if symptoms occur. Vaginal bleeding is the most common clinical presentation of endometrial cancer in postmenopausal women. Approximately 75% of postmenopausal women who are diagnosed with endometrial cancer are diagnosed at an early stage, which improves the chances of successful treatment. However, only 10% to 20% of postmenopausal women who are evaluated for uterine bleeding are diagnosed with endometrial cancer because the most common cause of postmenopausal bleeding is endometrial atrophy. All postmenopausal bleeding should be investigated, especially if risk factors for endometrial hyperplasia or cancer are present. Abnormal uterine bleeding can also be a sign of endometrial cancer in premenopausal women, who comprise 20% of cases of endometrial cancer. The American College of Obstetricians and Gynecologists (ACOG) recommends that women with abnormal uterine bleeding be evaluated for endometrial cancer if they are older than 45 years, or if they are younger than 45 years and have a history of unopposed estrogen exposure. Endometrial hyperplasia represents a precursor lesion to endometrial cancer. Hyperplasia carries a 1% to 3% risk of progression to cancer. Atypical hyperplasia is associated with greater cancer risk than simple or complex hyperplasia; 30% to 40% of patients with atypical hyperplasia have concomitant adenocarcinoma. Risk factors for type I endometrial cancer are related to unopposed exposure of the endometrium to estrogen, including unopposed estrogen therapy, early menarche, late menopause, tamoxifen therapy, nulliparity, infertility or failure to ovulate, and polycystic ovary syndrome. Nearly 70% of patients with early stage endometrial cancer are obese. The relative risk of death increases with rising body mass index. Patients undergoing treatment with tamoxifen are at increased risk of endometrial cancer. The ACS recommends that all women older than 65 years be informed of the risks and symptoms of endometrial cancer and advised to seek evaluation if symptoms occur. Management of risk factors such as obesity, diabetes, and hypertension could play a role in the prevention of endometrial cancer.

• #59 Recognizing Symptoms of Advanced Uterine Cancer

  https://www.healthline.com/health/advanced-uterine-cancer-symptoms

  Uterine cancer may not exhibit any symptoms in the early stages. So, if you do develop symptoms like pelvic pain, abnormal uterine bleeding, or unexplained weight loss, see your doctor right away for a diagnosis. […] Because theres no screening test for uterine cancer like the Pap test used to screen for cervical cancer, its important to become familiar with the symptoms. You may not experience any symptoms in the earliest stage. […] If you do begin to have symptoms that could be symptoms of uterine cancer, contact your doctor immediately. […] The most common symptom of endometrial cancer is abnormal uterine bleeding, which can occur during the early stages or later stages. […] Pelvic pain is a symptom of uterine cancer. And persistent pain in your lower abdomen or cramping could be a sign of uterine cancer that has spread. In fact, the American Cancer Society notes that pelvic pain is more common in the later stages of the disease.

• #60 Uterine cancer | Symptoms, Diagnosis, & Treatment | Britannica

  https://www.britannica.com/science/uterine-cancer

  The predominant early sign of endometrial cancer is vaginal bleeding or other discharge, especially in postmenopausal women. Any such discharge should be brought to the attention of a physician immediately. Additional possible symptoms are unexplained pelvic pain, a discernible lump or mass, and weight loss. […] Once uterine cancer has been diagnosed, its stage is then determined to indicate how far the cancer has progressed. Stage I cancers are localized to the main body of the uterus, whereas stage II tumours have spread to the cervix. Stage III cancers have spread outside the uterus to the vagina, regional lymph nodes, or peritoneum but are still contained within the pelvis. Stage IV cancers have spread to distant organs such as the lungs, bone, bladder, or digestive tract. […] Five-year survival for endometrial cancer is quite highmore than 90 percentwhen the cancer is diagnosed early. Among patients whose cancer has spread to the cervix, five-year survival typically is between 65 and 80 percent. If the cancer has spread beyond the endometrium but remains confined to the pelvis, five-year survival is roughly 50 percent. However, once the cancer has metastasized to other organs, the five-year survival rate is very low.

• #61 Endometrial cancer: MedlinePlus Medical EncyclopediaLock

  https://medlineplus.gov/ency/article/000910.htm

  Endometrial cancer is cancer that starts in the endometrium, the lining of the uterus (womb). […] Symptoms of endometrial cancer include: […] Abnormal bleeding from the vagina, including bleeding between periods or spotting/bleeding after menopause […] Extremely long, heavy, or frequent episodes of vaginal bleeding after age 40 […] Lower abdominal pain or pelvic cramping. […] Endometrial cancer is usually diagnosed at an early stage. […] If the cancer has not spread, 95% of women are alive 5 years after treatment. […] If the cancer has spread to distant organs, about 25% of women are still alive after 5 years.

• #62 Uterine cancer | Symptoms, Diagnosis, & Treatment | Britannica

  https://www.britannica.com/science/uterine-cancer

  The predominant early sign of endometrial cancer is vaginal bleeding or other discharge, especially in postmenopausal women. Any such discharge should be brought to the attention of a physician immediately. Additional possible symptoms are unexplained pelvic pain, a discernible lump or mass, and weight loss. […] Once uterine cancer has been diagnosed, its stage is then determined to indicate how far the cancer has progressed. Stage I cancers are localized to the main body of the uterus, whereas stage II tumours have spread to the cervix. Stage III cancers have spread outside the uterus to the vagina, regional lymph nodes, or peritoneum but are still contained within the pelvis. Stage IV cancers have spread to distant organs such as the lungs, bone, bladder, or digestive tract. […] Five-year survival for endometrial cancer is quite highmore than 90 percentwhen the cancer is diagnosed early. Among patients whose cancer has spread to the cervix, five-year survival typically is between 65 and 80 percent. If the cancer has spread beyond the endometrium but remains confined to the pelvis, five-year survival is roughly 50 percent. However, once the cancer has metastasized to other organs, the five-year survival rate is very low.

• #63 Uterine cancer | Symptoms, Diagnosis, & Treatment | Britannica

  https://www.britannica.com/science/uterine-cancer

  The predominant early sign of endometrial cancer is vaginal bleeding or other discharge, especially in postmenopausal women. Any such discharge should be brought to the attention of a physician immediately. Additional possible symptoms are unexplained pelvic pain, a discernible lump or mass, and weight loss. […] Once uterine cancer has been diagnosed, its stage is then determined to indicate how far the cancer has progressed. Stage I cancers are localized to the main body of the uterus, whereas stage II tumours have spread to the cervix. Stage III cancers have spread outside the uterus to the vagina, regional lymph nodes, or peritoneum but are still contained within the pelvis. Stage IV cancers have spread to distant organs such as the lungs, bone, bladder, or digestive tract. […] Five-year survival for endometrial cancer is quite highmore than 90 percentwhen the cancer is diagnosed early. Among patients whose cancer has spread to the cervix, five-year survival typically is between 65 and 80 percent. If the cancer has spread beyond the endometrium but remains confined to the pelvis, five-year survival is roughly 50 percent. However, once the cancer has metastasized to other organs, the five-year survival rate is very low.

• #64 Uterine cancer | Symptoms, Diagnosis, & Treatment | Britannica

  https://www.britannica.com/science/uterine-cancer

  The predominant early sign of endometrial cancer is vaginal bleeding or other discharge, especially in postmenopausal women. Any such discharge should be brought to the attention of a physician immediately. Additional possible symptoms are unexplained pelvic pain, a discernible lump or mass, and weight loss. […] Once uterine cancer has been diagnosed, its stage is then determined to indicate how far the cancer has progressed. Stage I cancers are localized to the main body of the uterus, whereas stage II tumours have spread to the cervix. Stage III cancers have spread outside the uterus to the vagina, regional lymph nodes, or peritoneum but are still contained within the pelvis. Stage IV cancers have spread to distant organs such as the lungs, bone, bladder, or digestive tract. […] Five-year survival for endometrial cancer is quite highmore than 90 percentwhen the cancer is diagnosed early. Among patients whose cancer has spread to the cervix, five-year survival typically is between 65 and 80 percent. If the cancer has spread beyond the endometrium but remains confined to the pelvis, five-year survival is roughly 50 percent. However, once the cancer has metastasized to other organs, the five-year survival rate is very low.

• #65 Uterine cancer | Symptoms, Diagnosis, & Treatment | Britannica

  https://www.britannica.com/science/uterine-cancer

  The predominant early sign of endometrial cancer is vaginal bleeding or other discharge, especially in postmenopausal women. Any such discharge should be brought to the attention of a physician immediately. Additional possible symptoms are unexplained pelvic pain, a discernible lump or mass, and weight loss. […] Once uterine cancer has been diagnosed, its stage is then determined to indicate how far the cancer has progressed. Stage I cancers are localized to the main body of the uterus, whereas stage II tumours have spread to the cervix. Stage III cancers have spread outside the uterus to the vagina, regional lymph nodes, or peritoneum but are still contained within the pelvis. Stage IV cancers have spread to distant organs such as the lungs, bone, bladder, or digestive tract. […] Five-year survival for endometrial cancer is quite highmore than 90 percentwhen the cancer is diagnosed early. Among patients whose cancer has spread to the cervix, five-year survival typically is between 65 and 80 percent. If the cancer has spread beyond the endometrium but remains confined to the pelvis, five-year survival is roughly 50 percent. However, once the cancer has metastasized to other organs, the five-year survival rate is very low.

• #66 Endometrial cancer: MedlinePlus Medical EncyclopediaLock

  https://medlineplus.gov/ency/article/000910.htm

  Endometrial cancer is cancer that starts in the endometrium, the lining of the uterus (womb). […] Symptoms of endometrial cancer include: […] Abnormal bleeding from the vagina, including bleeding between periods or spotting/bleeding after menopause […] Extremely long, heavy, or frequent episodes of vaginal bleeding after age 40 […] Lower abdominal pain or pelvic cramping. […] Endometrial cancer is usually diagnosed at an early stage. […] If the cancer has not spread, 95% of women are alive 5 years after treatment. […] If the cancer has spread to distant organs, about 25% of women are still alive after 5 years.

• #67 Uterine Cancer (Endometrial Cancer): Symptoms & Treatment

  https://my.clevelandclinic.org/health/diseases/16409-uterine-cancer

  Uterine cancer symptoms include bleeding between periods or after menopause. […] Signs of uterine cancer can resemble those of many conditions. […] Symptoms of endometrial cancer or uterine sarcoma include: Vaginal bleeding between periods before menopause. Vaginal bleeding or spotting after menopause, even a slight amount. Lower abdominal pain or cramping in your pelvis, just below your belly. Thin white or clear vaginal discharge if you’re postmenopausal. Extremely prolonged, heavy or frequent vaginal bleeding if you’re older than 40. […] The five-year survival rate for endometrial cancer is 81%. […] Fortunately, endometrial cancer is often diagnosed at an early stage. That’s because many people notice unusual bleeding and tell their healthcare providers. If cancer gets caught early and hasn’t spread to other organs, removing your uterus can cure it.

• #68 Different Types of Uterine Cancer: Risk Factors, Diagnosis, & Treatments | University of Kansas Cancer Center

  https://www.kucancercenter.org/news-room/blog/2020/09/uterine-cancer-types-risks-diagnosis-treatment

  Yes, women can fully recover from uterine cancer after aggressive treatment, like surgery and radiation. Many women feel better about 1-2 weeks following surgery and can resume normal activities after 1-2 months. Recovery from uterine cancer is more challenging if the cancer cells have metastasized to other parts of the body. The 5-year survival rate for all uterine cancer is 81.2%. The survival data are broken down further depending on how advanced the cancer is.

• #69 Uterine Cancer Clinical Presentation: History

  https://emedicine.medscape.com/article/258148-clinical

  More than 90% of patients with endometrial cancer will present with abnormal vaginal bleeding, whether it is menorrhagia, metrorrhagia, or any amount of postmenopausal bleeding. Approximately 10% of postmenopausal bleeding will lead to a diagnosis of endometrial cancer. Advanced cases, especially patients with uterine papillary serous or clear cell histologies may present with abdominal pain and bloating or other symptoms of metastatic disease. Other presenting symptoms may include purulent genital discharge, pain, weight loss, and a change in bladder or bowel habits. […] Fortunately, most cases of endometrial cancer are diagnosed prior to this clinical presentation because of the recognition of postmenopausal bleeding as a possible early symptom of cancer. About 5% of women may be asymptomatic and diagnosed after workup of abnormal Papanicolaou test results. […] Weight loss, anorexia, and change in bowel or bladder habits are signs of advanced disease in all cases of uterine cancer.

• #70 Endometrial (Uterine) Cancer | Kaiser Permanente

  https://healthy.kaiserpermanente.org/health-wellness/health-encyclopedia/he.endometrial-uterine-cancer.tm6524

  If endometrial cancer isn’t treated, it may spread outside of the uterus. It may spread to the pelvic lymph nodes and the vagina or other pelvic organs. Advanced-stage cancer may spread to other lymph nodes, the bladder, the bowels, or the lungs. […] The long-term outcome depends on the stage and grade of your cancer.

• #71 Uterine cancer | Symptoms, Diagnosis, & Treatment | Britannica

  https://www.britannica.com/science/uterine-cancer

  The predominant early sign of endometrial cancer is vaginal bleeding or other discharge, especially in postmenopausal women. Any such discharge should be brought to the attention of a physician immediately. Additional possible symptoms are unexplained pelvic pain, a discernible lump or mass, and weight loss. […] Once uterine cancer has been diagnosed, its stage is then determined to indicate how far the cancer has progressed. Stage I cancers are localized to the main body of the uterus, whereas stage II tumours have spread to the cervix. Stage III cancers have spread outside the uterus to the vagina, regional lymph nodes, or peritoneum but are still contained within the pelvis. Stage IV cancers have spread to distant organs such as the lungs, bone, bladder, or digestive tract. […] Five-year survival for endometrial cancer is quite highmore than 90 percentwhen the cancer is diagnosed early. Among patients whose cancer has spread to the cervix, five-year survival typically is between 65 and 80 percent. If the cancer has spread beyond the endometrium but remains confined to the pelvis, five-year survival is roughly 50 percent. However, once the cancer has metastasized to other organs, the five-year survival rate is very low.

• #72 What Are the First Signs of Uterine Cancer?

  https://www.aarp.org/health/conditions-treatments/info-2024/uterine-cancer-symptoms.html

  For women who are not in menopause, talk to your doctor if you notice bleeding between periods or a change in your periods, Soliman says. If you experience pain when you urinate or pain during intercourse, that could be another warning sign of uterine cancer. […] The American Cancer Society estimates that 70 percent of uterine cancers can be attributed to excess body weight and insufficient physical activity. […] Other risk factors for the cancer include a family history, having had breast or ovarian cancer, and having used the breast cancer treatment tamoxifen. […] When it comes to the increasing death rate, research shows that more women are being diagnosed with aggressive forms of uterine cancer than in the past, which could explain the shift. […] Theres a gap right now in knowledge about exactly why we are seeing an increase in cases and mortality, Matulonis says.

• #73 SIRT7 facilitates endometrial cancer progression by regulating PTEN stability in an estrogen-dependent manner | Nature Communications

  https://www.nature.com/articles/s41467-025-58317-0

  In poor prognosis EC subtypes, serous carcinoma, 45% of patients have PTEN protein level loss by immunohistochemistry (IHC) while the PTEN mutation rate is only about 7%. […] More importantly, the negative PTEN IHC staining is strongly related to a poor survival rate of patients with advanced EC. […] SIRT7 exhibits higher expression level in tumor samples compared to para-tumor samples. […] SIRT7 has the potential to facilitate tumor progression and may contribute to tumor metastasis in EC. […] SIRT7 knockdown reduced the migratory and invasive capacity of HEC-1B and KLE cells by wound healing and transwell assays. […] SIRT7 knockdown could abolish tumor metastasis ability in endometrial cancer both in vivo and in vitro. […] SIRT7-mediated PTEN deacetylation is functional in cell migration and invasion and the acetylation level at K260 of PTEN could serve as a prognosis marker for endometrial cancer metastasis. […] Our findings provided an insight of treatment for EC patients that targeting SIRT7 might be able to restore PTEN expression and restrain the EC advancement.

• #74 What Are the First Signs of Uterine Cancer?

  https://www.aarp.org/health/conditions-treatments/info-2024/uterine-cancer-symptoms.html

  For women who are not in menopause, talk to your doctor if you notice bleeding between periods or a change in your periods, Soliman says. If you experience pain when you urinate or pain during intercourse, that could be another warning sign of uterine cancer. […] The American Cancer Society estimates that 70 percent of uterine cancers can be attributed to excess body weight and insufficient physical activity. […] Other risk factors for the cancer include a family history, having had breast or ovarian cancer, and having used the breast cancer treatment tamoxifen. […] When it comes to the increasing death rate, research shows that more women are being diagnosed with aggressive forms of uterine cancer than in the past, which could explain the shift. […] Theres a gap right now in knowledge about exactly why we are seeing an increase in cases and mortality, Matulonis says.

• #75 Endometrial Cancer Symptoms, Diagnosis, and Treatment Options – Ezra

  https://ezra.com/blog/endometrial-cancer-symptoms

  Persistent or intermittent pelvic pain can be an indication of endometrial cancer, especially if it’s a new symptom for the individual. This can include: Dull aches to more severe cramps or pressure in the pelvic area, Painful intercourse, Pain when urinating or difficulty emptying the bladder. […] Sudden, unexplained weight loss can sometimes be a symptom of various types of cancer, including endometrial cancer. […] In advanced stages, the endometrial tumors might cause the uterus or the abdominal area to enlarge. […] Early detection of uterine and endometrial cancer significantly boosts survival rates. When diagnosed at an early stage, where the cancer is confined to the uterus, the chances of successful cancer care and long-term survival are much higher. […] Uncovering endometrial cancer symptoms early often means more treatment options are available, including less invasive surgical procedures and the potential to preserve fertility in younger people.

• #76 Endometrial Cancer – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK525981/

  Endometrial cancer is a malignancy originating within the epithelial lining of the uterus. Endometrial cancer is the most prevalent gynecologic malignancy in American women and a significant cause of morbidity and mortality. […] Clinicians must be equipped with the necessary clinical knowledge to evaluate patients presenting with symptoms such as abnormal uterine bleeding, pelvic pain, or uterine enlargementcommon manifestations of this condition. […] Common symptoms include abnormal uterine bleeding, pelvic pain, and uterine enlargement. […] Initial evaluation of endometrial cancer consists of a transvaginal ultrasound followed by an endometrial biopsy to confirm the diagnosis. […] Endometrial cancers confined to the uterus may present with minimal symptoms of abnormal uterine bleeding (AUB) to advanced disease with pelvic-abdominal discomfort and pain, widespread lymphatic and peritoneal dissemination, ascites, and rarely even extra-abdominal metastases. AUB is the most frequent symptom of endometrial cancer.

• #77 Warning Signs of Endometrial Cancer » Professor Andreas Obermair

  https://www.obermair.info/latest-news/blog/warning-signs-of-endometrial-cancer/

  Also known as uterine cancer, endometrial cancer begins from abnormal cells at the inner lining of the uterus (called the endometrium). […] There is no screening test for endometrial cancer, but there are signs and symptoms that appear early on in the development of endometrial cancer that should alert women. […] Early warning signs of endometrial cancer can include: Bloody, smelly or watery vaginal discharge, Bleeding between periods (spotting), Unusually heavy periods, Vaginal bleeding after menopause, Discomfort or pain in the abdomen, Difficulty or pain urinating, Unexplained weight loss, Pain during intercourse. […] If you have one or more of these symptoms you should speak to a doctor as soon as possible. […] The most common symptom of endometrial cancer is abnormal vaginal bleeding, particularly any bleeding after menopause is a sign of a problem. Endometrial cancer predominately affects post-menopausal women. In postmenopausal women, even one episode of bleeding (or even a streak of blood) is abnormal for women after menopause and needs to be investigated. All postmenopausal women who present to a GP with vaginal bleeding should be referred to a gynaecologist.

• #78 Uterine/Endometrial Cancer/GTD | Foundation For Women’s Cancer

  https://foundationforwomenscancer.org/gynecologic-cancers/gynecologic-cancer-types/uterine-endometrial-cancer-gtd/

  The most common warning sign for any uterine cancer is abnormal vaginal bleeding. Recognition of this symptom often affords an opportunity for early diagnosis and treatment. In postmenopausal people, any bleeding or spotting is abnormal and should prompt immediate evaluation by a gynecologist. Premenopausal reproductive age people who do not have regular monthly periods or who have excessive duration and/or quantity of bleeding each month should also be evaluated by a gynecologist as these can be symptoms of uterine cancer. Increasing pelvic pressure or abdominal girth, pelvic pain/fullness, increasing urinary frequency, or difficulty passing stool can sometimes be associated with an enlarging uterus. An enlarging uterus outside of pregnancy is often due to smooth muscle tumors and should be prompt evaluation by a gynecologist. […] The top of the vagina is the most common site of recurrent endometrial cancer, and patients will typically present with vaginal bleeding. […] Notify your physician if you develop abnormal bleeding or other unusual pelvic symptoms following treatment for endometrial cancer.

• #79 Uterine and Endometrial Cancer | Symptoms & Signs | MedStar Health

  https://www.medstarhealth.org/services/uterine-and-endometrial-cancer

  Symptoms will vary by woman, but the most frequent signs of uterine and endometrial cancers include: […] Abnormal uterine bleeding and/or abnormal menstrual periods […] Bleeding between normal periods, before menopause […] Vaginal bleeding or spotting after menopause […] Extremely long, heavy, or frequent episodes of vaginal bleeding after age 40 […] Lower abdominal pain or pelvic cramping […] Thin white or clear vaginal discharge after menopause. […] While these symptoms may be caused by other conditions, it’s important to seek care from your doctor early.

• #80 ‘How I knew I had endometrial (uterine) cancer’: Six survivors share symptoms  | MD Anderson Cancer Center

  https://www.mdanderson.org/cancerwise/-how-i-knew-i-had-endometrial-cancer—six-survivors-share-their-symptoms-stories.h00-159621801.html

  Not everyone with abnormal vaginal bleeding will be diagnosed with endometrial cancer. But other symptoms of this disease include pelvic pain, unexplained weight loss, and abnormal vaginal discharge. […] Moina Faruqui experienced the last symptom on that list for about three months before she was diagnosed with stage IV endometrial cancer at age 65. […] So, the bottom line is that if you have concerns about your cycle, or if you think you’re experiencing abnormal bleeding or any other symptom of endometrial cancer, talk to your gynecologist, she says. And, if you’re already in menopause and start bleeding again, get checked out. Because that’s not normal. Periods don’t just suddenly start up again years after they’ve stopped.

• #81 Signs of Endometrial Cancer You Shouldn’t Ignore » Professor Andreas Obermair

  https://www.obermair.info/latest-news/blog/from-bleeding-to-bloating-signs-of-endometrial-cancer-you-shouldnt-ignore/

  Endometrial cancer, which originates from the inner lining of the uterus (endometrium), can be challenging to detect early as its symptoms may be subtle or easily attributed to other conditions. Understanding the signs and symptoms of endometrial cancer is crucial for early diagnosis and effective treatment. […] […] Postmenopausal Bleeding: Any vaginal bleeding after menopause should be evaluated promptly. This includes spotting or any discharge. […] […] Irregular Menstrual Cycles: For women still menstruating, abnormal bleeding, such as bleeding between periods or unusually heavy periods, can be a sign. […] […] Pelvic Pain or Discomfort: Persistent pelvic pain, discomfort, or a feeling of fullness in the pelvic area can indicate endometrial cancer. This pain may be constant or intermittent. […]

• #82 Endometrial Cancer – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK525981/

  Irregular uterine bleeding associated with EIN and cancer can affect women of all ages, becoming more prevalent during the fifth decade of life, especially in women older than 45 years. […] Therefore, all women who are postmenopausal or women 45 and older with AUB should undergo diagnostic endometrial evaluation. […] However, endometrial cancer can also be found in premenopausal women, particularly individuals with risk factors for endometrial hyperplasia. […] Approximately 75% of women diagnosed with endometrial cancer younger than 25 years also had a body mass index greater than 30. […] Therefore, any premenopausal woman with AUB and risk factors for endometrial cancer (eg, Lynch syndrome), exposure to unopposed estrogen (eg, obesity, exogenous estrogen, and polycystic ovarian syndrome), or persistent or recurrent AUB should prompt endometrial assessment to exclude hyperplasia, malignancy, and other differential diagnoses. […] Less frequent endometrial cancer symptoms include abnormal vaginal discharge, pelvic pain, constipation, or diarrhea.

• #83 Endometrial Cancer – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK525981/

  Irregular uterine bleeding associated with EIN and cancer can affect women of all ages, becoming more prevalent during the fifth decade of life, especially in women older than 45 years. […] Therefore, all women who are postmenopausal or women 45 and older with AUB should undergo diagnostic endometrial evaluation. […] However, endometrial cancer can also be found in premenopausal women, particularly individuals with risk factors for endometrial hyperplasia. […] Approximately 75% of women diagnosed with endometrial cancer younger than 25 years also had a body mass index greater than 30. […] Therefore, any premenopausal woman with AUB and risk factors for endometrial cancer (eg, Lynch syndrome), exposure to unopposed estrogen (eg, obesity, exogenous estrogen, and polycystic ovarian syndrome), or persistent or recurrent AUB should prompt endometrial assessment to exclude hyperplasia, malignancy, and other differential diagnoses. […] Less frequent endometrial cancer symptoms include abnormal vaginal discharge, pelvic pain, constipation, or diarrhea.

• #84 Endometrial Cancer Misdiagnosed – Signs and Symptoms

  https://paulandperkins.com/endometrial-cancer/

  Endometrial cancer is often caught in early stages because one of the most common early symptoms is abnormal vaginal bleeding, which women will typically consult a doctor about. This bleeding sometimes occurs in between periods or after menopause, which is a warning sign. In some cases, a watery discharge will accompany the abnormal bleeding. Pain during intercourse or lower abdominal pain in general may also be signs of endometrial cancer. […] Endometrial cancer may be difficult to diagnose in early stages, as pelvic examinations will yield normal results until the disease has progressed. […] In cases where the patient does have endometrial cancer and there is a delayed diagnosis, misdiagnosis, or failure to diagnose, the cancer is being allowed to progress and spread without treatment. In these cases, the condition may pass the point of curability or before a proper diagnosis can be made. In some cases, the patient may even die before the endometrial cancer is correctly diagnosed.

• #85 Endometrial Cancer Symptoms | Power

  https://www.withpower.com/guides/endometrial-cancer-symptoms

  Endometrial cancer signs and clinical manifestations include: […] The presence of cancerous or atypical endometrial cells on a Pap test is an indication of endometrial cancer. […] A thickened endometrium in patients who report post-menopausal bleeding requires further investigation for endometrial cancer diagnosis. Endometrial cancer appears as a thickening of the uterine lining that resembles a polypoid mass. The thickness of the endometrium must depend on the menstrual cycle stage of the patient. However, if the endometrium is more than 5 mm in thickness in post-menopausal women, it indicates an abnormality. […] Irregular thickening of the endometrium, intrauterine fluid collection, polypoid mass lesion, and myometrial invasion also suggest that the abnormality in sonographic features is due to endometrial carcinoma.

• #86 Endometrial Cancer – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK525981/

  Endometrial cancer is a malignancy originating within the epithelial lining of the uterus. Endometrial cancer is the most prevalent gynecologic malignancy in American women and a significant cause of morbidity and mortality. […] Clinicians must be equipped with the necessary clinical knowledge to evaluate patients presenting with symptoms such as abnormal uterine bleeding, pelvic pain, or uterine enlargementcommon manifestations of this condition. […] Common symptoms include abnormal uterine bleeding, pelvic pain, and uterine enlargement. […] Initial evaluation of endometrial cancer consists of a transvaginal ultrasound followed by an endometrial biopsy to confirm the diagnosis. […] Endometrial cancers confined to the uterus may present with minimal symptoms of abnormal uterine bleeding (AUB) to advanced disease with pelvic-abdominal discomfort and pain, widespread lymphatic and peritoneal dissemination, ascites, and rarely even extra-abdominal metastases. AUB is the most frequent symptom of endometrial cancer.

• #87 How We Diagnose Endometrial Cancer | Dana-Farber Cancer Institute

  https://www.dana-farber.org/cancer-care/types/endometrial-cancer/diagnosis

  Many people come to Dana-Farber Brigham Cancer Center after consulting with their regular gynecologist about symptoms, such as abnormal discharge or bleeding. […] It’s important that you maintain regular gynecology evaluations and notify your doctor at the first sign of changes or symptoms such as abnormal bleeding, spotting, or discharge between periods or after menopause. […] When symptoms suggest endometrial cancer, the following tests may be used to detect cancer: […] Cancer can be confirmed only by removing a small sample of tissue or cells (biopsy). […] If endometrial cancer is found after examining uterine tissue samples, further tests may be done to see if the cancer cells have spread within the uterus or to other parts of the body. […] Information from exams and diagnostic tests is used to determine the extent of the tumor, and whether or not the cancer has spread to the lymph nodes or other organs.

• #88 How We Diagnose Endometrial Cancer | Dana-Farber Cancer Institute

  https://www.dana-farber.org/cancer-care/types/endometrial-cancer/diagnosis

  Many people come to Dana-Farber Brigham Cancer Center after consulting with their regular gynecologist about symptoms, such as abnormal discharge or bleeding. […] It’s important that you maintain regular gynecology evaluations and notify your doctor at the first sign of changes or symptoms such as abnormal bleeding, spotting, or discharge between periods or after menopause. […] When symptoms suggest endometrial cancer, the following tests may be used to detect cancer: […] Cancer can be confirmed only by removing a small sample of tissue or cells (biopsy). […] If endometrial cancer is found after examining uterine tissue samples, further tests may be done to see if the cancer cells have spread within the uterus or to other parts of the body. […] Information from exams and diagnostic tests is used to determine the extent of the tumor, and whether or not the cancer has spread to the lymph nodes or other organs.

• #89 Symptoms and diagnosis of endometrial cancer – Institut Curie

  https://institut-curie.org/symptomes-et-diagnostic-du-cancer-de-lendometre

  The symptoms of endometrial cancer are: Abnormal vaginal bleeding (metrorrhagia) in women after the menopause or outside the menstrual period in non-menopausal women; Pelvic pain. […] Once the diagnosis of cancer has been established, further investigations are prescribed to explore its extent locally (lumbopelvic MRI, i.e. to explore the pelvis and lumbo-aortic lymph nodes) and sometimes throughout the body (thoraco-abdomino-pelvic CT or PET scan).

• #90 Endometrial cancer – Symptoms and causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/endometrial-cancer/symptoms-causes/syc-20352461

  Endometrial cancer is often found at an early stage because it causes symptoms. Often the first symptom is irregular vaginal bleeding. […] Symptoms of endometrial cancer may include: Vaginal bleeding after menopause. […] If endometrial cancer is found early, surgically removing the uterus often cures it. […] Bleeding between periods. […] Pelvic pain.

• #91 Endometrial cancer – Symptoms, diagnosis and treatment | BMJ Best Practice US

  https://bestpractice.bmj.com/topics/en-us/266

  Endometrial cancer is a common malignancy, usually an adenocarcinoma. […] Patients typically present with postmenopausal vaginal bleeding and often have surgically curable disease. […] Key diagnostic factors include postmenopausal vaginal bleeding (PVB). […] Other diagnostic factors include uterine mass, fixed uterus, or adnexal mass indicating extrauterine disease, abnormal menstruation or vaginal bleeding in a premenopausal woman, pain (abdominal or pelvic) and weight loss, symptoms of metastatic disease, and signs of metastatic disease. […] Adjuvant vaginal brachytherapy and pelvic external beam radiation therapy can improve progression-free survival in patients with high-intermediate risk or high-risk disease, but they do not improve overall survival. […] Chemotherapy, with or without immunotherapy, and chemoradiotherapy are options for patients with stages III and IV disease at presentation.

• #92 Endometrial cancer – Symptoms, diagnosis and treatment | BMJ Best Practice US

  https://bestpractice.bmj.com/topics/en-us/266

  Endometrial cancer is a common malignancy, usually an adenocarcinoma. […] Patients typically present with postmenopausal vaginal bleeding and often have surgically curable disease. […] Key diagnostic factors include postmenopausal vaginal bleeding (PVB). […] Other diagnostic factors include uterine mass, fixed uterus, or adnexal mass indicating extrauterine disease, abnormal menstruation or vaginal bleeding in a premenopausal woman, pain (abdominal or pelvic) and weight loss, symptoms of metastatic disease, and signs of metastatic disease. […] Adjuvant vaginal brachytherapy and pelvic external beam radiation therapy can improve progression-free survival in patients with high-intermediate risk or high-risk disease, but they do not improve overall survival. […] Chemotherapy, with or without immunotherapy, and chemoradiotherapy are options for patients with stages III and IV disease at presentation.

• #93 Endometrial cancer – Symptoms, diagnosis and treatment | BMJ Best Practice US

  https://bestpractice.bmj.com/topics/en-us/266

  Endometrial cancer is a common malignancy, usually an adenocarcinoma. […] Patients typically present with postmenopausal vaginal bleeding and often have surgically curable disease. […] Key diagnostic factors include postmenopausal vaginal bleeding (PVB). […] Other diagnostic factors include uterine mass, fixed uterus, or adnexal mass indicating extrauterine disease, abnormal menstruation or vaginal bleeding in a premenopausal woman, pain (abdominal or pelvic) and weight loss, symptoms of metastatic disease, and signs of metastatic disease. […] Adjuvant vaginal brachytherapy and pelvic external beam radiation therapy can improve progression-free survival in patients with high-intermediate risk or high-risk disease, but they do not improve overall survival. […] Chemotherapy, with or without immunotherapy, and chemoradiotherapy are options for patients with stages III and IV disease at presentation.

• #94 Endometrial cancer – Symptoms, diagnosis and treatment | BMJ Best Practice US

  https://bestpractice.bmj.com/topics/en-us/266

  Endometrial cancer is a common malignancy, usually an adenocarcinoma. […] Patients typically present with postmenopausal vaginal bleeding and often have surgically curable disease. […] Key diagnostic factors include postmenopausal vaginal bleeding (PVB). […] Other diagnostic factors include uterine mass, fixed uterus, or adnexal mass indicating extrauterine disease, abnormal menstruation or vaginal bleeding in a premenopausal woman, pain (abdominal or pelvic) and weight loss, symptoms of metastatic disease, and signs of metastatic disease. […] Adjuvant vaginal brachytherapy and pelvic external beam radiation therapy can improve progression-free survival in patients with high-intermediate risk or high-risk disease, but they do not improve overall survival. […] Chemotherapy, with or without immunotherapy, and chemoradiotherapy are options for patients with stages III and IV disease at presentation.

• #95 Endometrial cancer – Symptoms, diagnosis and treatment | BMJ Best Practice US

  https://bestpractice.bmj.com/topics/en-us/266

  Endometrial cancer is a common malignancy, usually an adenocarcinoma. […] Patients typically present with postmenopausal vaginal bleeding and often have surgically curable disease. […] Key diagnostic factors include postmenopausal vaginal bleeding (PVB). […] Other diagnostic factors include uterine mass, fixed uterus, or adnexal mass indicating extrauterine disease, abnormal menstruation or vaginal bleeding in a premenopausal woman, pain (abdominal or pelvic) and weight loss, symptoms of metastatic disease, and signs of metastatic disease. […] Adjuvant vaginal brachytherapy and pelvic external beam radiation therapy can improve progression-free survival in patients with high-intermediate risk or high-risk disease, but they do not improve overall survival. […] Chemotherapy, with or without immunotherapy, and chemoradiotherapy are options for patients with stages III and IV disease at presentation.

• #96 Endometrial cancer: MedlinePlus Medical EncyclopediaLock

  https://medlineplus.gov/ency/article/000910.htm

  Endometrial cancer is cancer that starts in the endometrium, the lining of the uterus (womb). […] Symptoms of endometrial cancer include: […] Abnormal bleeding from the vagina, including bleeding between periods or spotting/bleeding after menopause […] Extremely long, heavy, or frequent episodes of vaginal bleeding after age 40 […] Lower abdominal pain or pelvic cramping. […] Endometrial cancer is usually diagnosed at an early stage. […] If the cancer has not spread, 95% of women are alive 5 years after treatment. […] If the cancer has spread to distant organs, about 25% of women are still alive after 5 years.

• #97 Different Types of Uterine Cancer: Risk Factors, Diagnosis, & Treatments | University of Kansas Cancer Center

  https://www.kucancercenter.org/news-room/blog/2020/09/uterine-cancer-types-risks-diagnosis-treatment

  Yes, women can fully recover from uterine cancer after aggressive treatment, like surgery and radiation. Many women feel better about 1-2 weeks following surgery and can resume normal activities after 1-2 months. Recovery from uterine cancer is more challenging if the cancer cells have metastasized to other parts of the body. The 5-year survival rate for all uterine cancer is 81.2%. The survival data are broken down further depending on how advanced the cancer is.

• #98 Different Types of Uterine Cancer: Risk Factors, Diagnosis, & Treatments | University of Kansas Cancer Center

  https://www.kucancercenter.org/news-room/blog/2020/09/uterine-cancer-types-risks-diagnosis-treatment

  Yes, women can fully recover from uterine cancer after aggressive treatment, like surgery and radiation. Many women feel better about 1-2 weeks following surgery and can resume normal activities after 1-2 months. Recovery from uterine cancer is more challenging if the cancer cells have metastasized to other parts of the body. The 5-year survival rate for all uterine cancer is 81.2%. The survival data are broken down further depending on how advanced the cancer is.

• #99 Endometrial (Uterine) Cancer | Kaiser Permanente

  https://healthy.kaiserpermanente.org/health-wellness/health-encyclopedia/he.endometrial-uterine-cancer.tm6524

  Abnormal or unexpected bleeding from the vagina is the most common symptom of endometrial cancer. […] Symptoms of more advanced endometrial cancer include pain or a lump in the pelvic area and weight loss. […] Symptoms of more advanced endometrial cancer include: Pain in the pelvic area. A pelvic lump. Weight loss. […] When endometrial cancer comes back after treatment, you will probably have symptoms. These include: Bleeding from the vagina, bladder, or rectum. Decreased appetite. Weight loss. Pain in your belly, hip, or back. Cough. Shortness of breath. Swelling in your belly or legs. […] Normally, the lining of the uterus (endometrium) builds up and then sheds with each menstrual cycle. But in most cases of endometrial cancer, the endometrium has built up and has not shed and thinned. The lining has remained thick. This is called endometrial hyperplasia. If not treated, the lining cells can grow quickly and become cancer cells.

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