Limfadenitis mezenterialny
Etiologia i przyczyny
Limfadenitis mezenterialny to zapalenie węzłów chłonnych krezki, najczęściej występujące u dzieci i młodzieży, rzadko u osób powyżej 20. roku życia. Etiologia obejmuje infekcje wirusowe (stanowiące do 60% przypadków), takie jak rotawirusy, norowirusy, adenowirusy (serotypy 1, 2, 3, 5, 7), wirus Epsteina-Barr, wirus odry, wirusy Coxsackie oraz HIV. Bakterie, w tym Yersinia enterocolitica (najczęstsza przyczyna w krajach zachodnich), Yersinia pseudotuberculosis, paciorkowce beta-hemolizujące, gronkowce, Escherichia coli, Salmonella, Mycobacterium tuberculosis, Bartonella henselae, Campylobacter jejuni, Helicobacter jejuni i Shigella spp., stanowią drugi co do częstości czynnik etiologiczny. Rzadziej zapalenie wywołują pasożyty, takie jak Giardia lamblia i Cryptosporidium. W diagnostyce istotne jest rozpoznanie powiększenia węzłów chłonnych – patologiczne jest skupisko ≥3 węzłów o średnicy >5 mm w osi krótkiej, choć proponuje się podniesienie progu do 8 mm, aby ograniczyć fałszywie dodatnie wyniki.
Etiologia limfadenitis mezenterialny
Limfadenitis mezenterialny (zapalenie węzłów chłonnych krezki) to stan zapalny węzłów chłonnych w jamie brzusznej, zlokalizowanych w krezce, czyli błonie łączącej jelito ze ścianą jamy brzusznej. Choroba ta występuje głównie u dzieci i młodzieży, rzadko dotykając osoby powyżej 20. roku życia. Patogeneza schorzenia obejmuje szereg czynników etiologicznych, które można sklasyfikować jako pierwotne i wtórne.123
Klasyfikacja etiologiczna
Zapalenie węzłów chłonnych krezki można podzielić na dwie główne kategorie etiologiczne:123
- Pierwotne zapalenie węzłów chłonnych krezki – występuje, gdy limfadenopatia jest wynikiem niezidentyfikowanego procesu zapalnego; przyczyna nie jest możliwa do określenia.
- Wtórne zapalenie węzłów chłonnych krezki – pojawia się w następstwie procesu zapalnego w jamie brzusznej o znanym źródle lub etiologii.
Infekcje wirusowe
Najczęstszą przyczyną limfadenitis mezenterialny są infekcje wirusowe. Szacuje się, że nawet do 60% przypadków jest spowodowanych przez wirusy.123 Do najczęściej identyfikowanych wirusów należą:
- Wirusy wywołujące zapalenie żołądka i jelit (gastroenteritis), często określane jako „grypa żołądkowa”, w tym:
- Rotawirus
- Norwowirus
- Adenowirusy (serotypy 1, 2, 3, 5 i 7)
- Wirus Epsteina-Barr (EBV)
- Wirus odry (rubeola)
- Wirusy Coxsackie (A i B)
- HIV – infekcje związane bezpośrednio lub pośrednio z wirusem HIV
Częste powiązanie tego schorzenia, szczególnie u dzieci, z infekcjami górnych dróg oddechowych przyczyniło się do teorii, że połknięta wydzielina zawierająca patogeny może być pierwotnym źródłem zakażenia.1 Infekcje wirusowe mogą rozprzestrzeniać się z układu oddechowego do przewodu pokarmowego i dalej do węzłów chłonnych krezki.2
Infekcje bakteryjne
Bakterie są drugim najczęstszym czynnikiem etiologicznym limfadenitis mezenterialny. Do najważniejszych patogenów bakteryjnych należą:12
- Yersinia enterocolitica – uważana za najczęstszą przyczynę limfadenitis mezenterialny u dzieci w Ameryce Północnej, Europie i Australii. Bakteria ta jest często znajdowana w niedogotowanym mięsie, szczególnie wieprzowinie.123
- Yersinia pseudotuberculosis – blisko spokrewniona z Y. enterocolitica, również często identyfikowana w przypadkach limfadenitis mezenterialny.1
- Paciorkowce beta-hemolizujące (Streptococcus)
- Gronkowce (Staphylococcus species)
- Escherichia coli
- Streptococcus viridans
- Salmonella – różne serotypy
- Mycobacterium tuberculosis – bakteria wywołująca gruźlicę, która może atakować nie tylko płuca, ale również inne części ciała, w tym przewód pokarmowy
- Bartonella henselae – bakteria odpowiedzialna za chorobę kociego pazura
- Campylobacter jejuni
- Helicobacter jejuni
- Shigella spp.
Zakażenie bakterią Yersinia enterocolitica może rozprzestrzeniać się drogą fekalno-oralną i może występować jako ognisko epidemiczne z wspólnego źródła. Infekcja ta była również związana z zanieczyszczeniem mięsa, mleka i wody. Rzadko kontakt bezpośredni lub pośredni z nosicielami bakterii w kale może prowadzić do zakażenia.12
Infekcje pasożytnicze
Choć rzadziej spotykane, również pasożyty mogą wywoływać zapalenie węzłów chłonnych krezki:12
Choroby zapalne i inne stany
Limfadenitis mezenterialny może również wystąpić jako konsekwencja innych stanów zapalnych w jamie brzusznej:12
- Zapalenie wyrostka robaczkowego (appendicitis)
- Choroby zapalne jelit, takie jak:
- Choroba Leśniowskiego-Crohna
- Wrzodziejące zapalenie jelita grubego
- Ostre terminalne zapalenie jelita krętego (acute terminal ileitis) – zapalenie końcowego odcinka jelita cienkiego, które może być spowodowane przez bakterie lub chorobę Leśniowskiego-Crohna
- Choroby tkanki łącznej, takie jak:
- Toczeń rumieniowaty układowy
- Stwardnienie
- Reumatoidalne zapalenie stawów
- Zapalenie uchyłków jelita (diverticulitis) – zapalenie wyściółki jelita grubego
- Zapalenie trzustki (pancreatitis)
Nowotwory
W rzadkich przypadkach, limfadenitis mezenterialny może być związane z procesami nowotworowymi:12
- Chłoniak (nowotwór układu limfatycznego)
- Rak płuc
- Rak trzustki
- Nowotwory przewodu pokarmowego
- Rak piersi
Czynniki ryzyka
Czynniki zwiększające ryzyko wystąpienia limfadenitis mezenterialny obejmują:12
- Wiek – choroba jest znacznie częstsza u dzieci i młodzieży, rzadko występuje u osób powyżej 20. roku życia
- Przebyte infekcje wirusowe lub bakteryjne, szczególnie:
- Infekcje żołądkowo-jelitowe
- Infekcje górnych dróg oddechowych
- Spożycie niedogotowanego mięsa, szczególnie wieprzowiny zanieczyszczonej bakterią Y. enterocolitica
- Istniejące choroby zapalne przewodu pokarmowego
Patofizjologia
Mechanizm rozwoju zapalenia węzłów chłonnych krezki obejmuje kilka etapów:12
- Drobnoustroje chorobotwórcze są zwykle przyjmowane drogą pokarmową i powodują zapalenie żołądka i jelit
- Patogeny przedostają się do węzłów chłonnych krezki przez układ limfatyczny przewodu pokarmowego
- W węzłach chłonnych następuje namnażanie się patogenów, co prowadzi do lokalnej odpowiedzi zapalnej
- W wyniku tego procesu dochodzi do powiększenia węzłów chłonnych i pojawienia się bólu brzucha oraz objawów ogólnoustrojowych
Według badań, najczęstszymi przyczynami limfadenitis mezenterialny u dzieci są: infekcje dróg oddechowych (36,8%), biegunka (28%), infekcje dróg moczowych (12,2%), inwazje pasożytnicze (10,5%), dur brzuszny (7%) oraz zapalenie żołądka (5,2%).1
Diagnostyka obrazowa
W diagnostyce limfadenitis mezenterialny istotna jest ocena wielkości węzłów chłonnych. Za patologiczne uważa się skupisko trzech lub więcej węzłów chłonnych o wielkości powyżej 5 mm w osi krótkiej. Jednakże niektórzy badacze sugerują rewizję tego kryterium i podniesienie wartości granicznej do 8 mm w osi krótkiej, aby zmniejszyć liczbę wyników fałszywie dodatnich.12
Należy podkreślić, że u wielu dzieci z nawracającymi bólami brzucha nie można ustalić organicznej przyczyny, a nawet gdy wykrywa się nieprawidłowości, może być trudno powiązać je z bólem brzucha. Istnieją kontrowersje dotyczące kryteriów diagnostycznych powiększenia węzłów chłonnych krezki.12
Podsumowanie etiologii
Limfadenitis mezenterialny jest stanem zapalnym węzłów chłonnych krezki, który może być wywołany przez różnorodne czynniki, z których najczęstszymi są infekcje wirusowe i bakteryjne. Choroba ta występuje głównie u dzieci i młodzieży, rzadko dotykając osób dorosłych. W większości przypadków ma przebieg samoograniczający się i ustępuje samoistnie bez konieczności leczenia. Jednakże ze względu na podobieństwo objawów do zapalenia wyrostka robaczkowego, często wymaga dokładnej diagnostyki różnicowej.123
Zrozumienie etiologii limfadenitis mezenterialny jest kluczowe dla prawidłowego rozpoznania i leczenia tego schorzenia, które mimo że zazwyczaj łagodne, może powodować znaczny dyskomfort i niepokój, szczególnie u dzieci i ich rodziców. Dalsze badania nad patogenezą tej choroby mogą przyczynić się do opracowania bardziej skutecznych metod diagnostycznych i terapeutycznych.12
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Materiały źródłowe
- #1 Mesenteric Adenitis – StatPearls – NCBI Bookshelfhttps://www.ncbi.nlm.nih.gov/sites/books/NBK560822/
Mesenteric adenitis is a syndrome characterized by right lower quadrant pain secondary to an inflammatory condition of mesenteric lymph nodes. […] The etiologies of mesenteric adenitis include several causes of inflammatory response within mesenteric lymph nodes. These include viral infections, bacterial infections, inflammatory bowel disease, or lymphoma. Two common gram-negative bacteria that are known to cause mesenteric adenitis include Yersinia pseudotuberculosis and Yersinia enterocolitica. […] Other known culprits include salmonella, E coli, and streptococci. The etiology can further classify as primary versus secondary. Primary etiology occurs when the lymphadenopathy is the result of an unidentifiable inflammatory process. Secondary mesenteric adenitis occurs secondary to an intra-abdominal inflammatory process with a known source or etiology.
- #1 Mesenteric Lymphadenitis – Causes, Symptoms, Diagnosis and Treatmenthttps://www.abdopain.com/mesenteric-lymphadenitis.html
Mesenteric lymphadenitis is the inflammation of the lymph nodes on the wall of the mesentery (the covering of the intestines) in the absence of appendicitis, leading to abdominal pain. […] The following are the usual causes of mesenteric lymphadenitis: […] Several studies have shown that up to 60 percent of mesenteric lymphadenitis are caused by viruses. […] Bacteria contamination of food can mesenteric lymphadenitis. […] Parasitic protozoa has also been shown to cause mesenteric adenitis. […] Any of these infections – virus, bacteria or parasite can get into our intestine and get trapped inside the lymph nodes on the mesentery and trigger an inflammation, leading to the enlargement of the lymph nodes and the symptoms of mesenteric lymphadenitis.
- #1 Mesenteric Lymphadenitis: Background, Pathophysiology, Etiologyhttps://emedicine.medscape.com/article/181162-overview
Numerous organisms have been cultured from mesenteric lymph nodes and blood, such as beta-hemolytic streptococcus, Staphylococcus species, Escherichia coli, Streptococcus viridans, Yersinia species (responsible for most cases currently), Mycobacterium tuberculosis, Giardia lamblia, and nonSalmonella typhoid. Viruses, such as coxsackieviruses (A and B), rubeola virus, and adenovirus serotypes 1, 2, 3, 5, and 7, have also been implicated. […] Mesenteric node involvement can also be part of infectious Epstein-Barr virus (EBV), acute human immunodeficiency virus (HIV) infection, and catscratch disease (CSD). […] The frequent association of this condition, especially in children with upper respiratory tract infection, has popularized a theory that swallowed pathogen-laden sputum may be the primary source of infection. […] Fecal-oral transmission occurs in Y enterocolitica infection and may present as a common source outbreak. This infection has also been associated with meat, milk, and water contamination. Rarely, person-to-person or zoonotic contacts with fecal carriers can lead to infection.
- #1 Mesenteric Lymphadenitis: Causes, Symptoms, and Treatmenthttps://www.webmd.com/children/mesenteric-lymphadentitis?page
Mesenteric lymphadenitis is an inflammation of lymph nodes. The most common cause is infection, such as a viral or bacterial stomach bug. […] Infections that cause mesenteric lymphadenitis may be located in one place (local) or throughout the body (systemic). The infections may be caused by: Viruses, Bacteria, Parasites. […] Common infections that cause mesenteric lymphadenitis include: Gastroenteritis. This may result from viral infections such as rotavirus or norovirus. It may also result from bacterial infections such as salmonella, staphylococcus, or streptococcus. […] Yersinia enterocolitica. This is the most common cause of mesenteric lymphadenitis in children. This bacteria, found in undercooked meat, can cause gastroenteritis and other problems. […] Other infections that cause mesenteric lymphadenitis include: Direct or indirect infections related to HIV. This is the virus that can lead to AIDS.
- #1 Mesenteric Lymphadenitis: Causes, Symptoms, and Treatmenthttps://www.webmd.com/children/mesenteric-lymphadentitis?page
Tuberculosis. This is a bacterial infection that usually attacks the lungs. But it can also attack other parts of the body. […] Acute terminal ileitis. This is an inflammation of the end of the small intestine. It may be due to a bacterium or Crohn’s disease. […] Inflammatory conditions commonly linked to mesenteric lymphadenitis are: Appendicitis, inflammation of the appendix; Inflammatory bowel diseases such as Crohn’s disease or ulcerative colitis; Connective tissue diseases such as lupus, sclerosis, or rheumatoid arthritis. […] Diverticulitis, inflammation of the lining of the large intestine, and pancreatitis, inflammation of the pancreas, are less common causes.
- #1 Mesenteric lymphadenitis – Humanitas.nethttps://www.humanitas.net/diseases/mesenteric-lymphadenitis/
Mesenteric lymphadenitis refers to the inflammation of the mesenteric lymph nodes, which are tissues that help the body fight off illness. […] Depending on the causative agent, this intestinal inflammation may be acute or chronic. […] Infections that cause mesenteric lymphadenitis may be located locally or throughout the body. The infections may be caused by viruses, bacteria or parasites. Common infections that cause mesenteric lymphadenitis include: Gastroenteritis that may result from viral infections such as rotavirus or norovirus. It may also result from bacterial infections such as salmonella, staphylococcus, or streptococcus. […] Other infections that cause mesenteric lymphadenitis include: Direct or indirect infections related to HIV; Tuberculosis; Whipple disease; Acute terminal ileitis; Lymphoma; Breast cancer; Lung cancer; Pancreatic cancer; Gastrointestinal cancer.
- #1 Mayo Clinic Health Library – Mesenteric lymphadenitis | Swiss Medical Networkhttps://www.swissmedical.net/en/healtcare-library/con-20193989
An infection in the intestines, such as a virus, is the usual cause of mesenteric lymphadenitis. […] The most common cause of mesenteric lymphadenitis is a viral infection, such as gastroenteritis. Gastroenteritis is often called stomach flu. This infection causes inflammation and swelling in the lymph nodes in the thin tissue that attaches the intestine to the back of the wall around the stomach area, called mesentery. […] Other causes of mesenteric lymphadenitis include bacterial infection, inflammatory bowel disease and lymphoma. […] Any infection that causes inflammation and swelling in the lymph nodes in the tissue that attaches the bowel to the abdominal wall increases the risk of mesenteric lymphadenitis. […] Conditions that raise the risk of mesenteric lymphadenitis include: Viral or bacterial gastroenteritis, Inflammatory bowel disease, Lymphoma.
- #1 What Are the Common Risk Factors of Mesenteric Adenitis?https://www.afcurgentcare.com/sevierville-tn/blog/what-are-the-common-risk-factors-of-mesenteric-adenitis/
Mesenteric adenitis (also known as mesenteric lymphadenitis) is the swelling of the lymph nodes in the mesentery, which attaches the intestines to the abdominal wall. […] Mesenteric adenitis is most often caused by a viral or bacterial intestinal infection, which causes the lymph nodes to swell, thus inducing pain and tenderness. […] Because mesenteric adenitis is almost always caused by a bacterial or viral infection, it is unlikely to appear out of nowhere. Lymphadenitis is almost always the result of a previous infection, such as a stomach virus, a cold virus or a respiratory infection. Y. enterocolitica-infected pork can also cause lymphadenitis.
- #1https://www.ijpediatrics.com/index.php/ijcp/article/view/284
The aim was to study the clinical profile and causes of mesenteric lymphadenitis in children. […] The commonest cause of mesenteric lymphadenitis was found to be respiratory tract infection in 36.8% of patients followed by diarrhea 28%, urinary tract infection 12.2%, worm infestations 10.5%, enteric fever 7%, gastritis 5.2%.
- #1 Pulsenotes | Mesenteric adenitishttps://app.pulsenotes.com/specialities/paediatrics/notes/mesenteric-adenitis
Mesenteric adenitis refers to acute or chronic inflammation of the mesenteric lymph nodes. […] Mesenteric adenitis is commonly due to viruses. […] Mesenteric adenitis often follows viral or bacterial gastroenteritis with a range of organisms implicated: Viruses: coxsackieviruses, rubeola virus, adenovirus; Bacteria: Yersinia species, Streptococcus, Staphylococcus, Escherichia coli. […] These organisms are usually ingested orally and then reach the mesenteric lymph nodes via the gastrointestinal lymphatic system and undergo replication. This leads to local inflammatory responses, lymph node enlargement, and subsequent abdominal pain with systemic symptoms.
- #1https://www.archivesofmedicalscience.com/Acute-mesenteric-lymphadenitis-in-children-findings-related-to-differential-diagnosis,95258,0,2.html
Acute mesenteric lymphadenitis causes right lower quadrant (RLQ) pain as in AA and its etiology may be due to primary (idiopathic) or secondary (infection, malignancy, etc.) reasons. […] The consensus regarding the radiological and laboratory parameters which may be consistent with AML in the literature is still controversial. […] It has been supposed that a cluster of three or more lymph nodes measuring more than 5 mm along their short axis in AML was the pathologic condition. […] In our study, we found that abdominal pain and nausea-vomiting occurred at different rates independently of the short-axis diameter of the mesenteric lymph node. […] In the ROC curve analysis, the L/M ratio was the most specific and the most sensitive parameter we used when making a differential diagnosis between AA and AML groups.
- #1https://journals.lww.com/jmsc/fulltext/2023/25010/relevance_of_mesenteric_lymphadenopathy_in.17.aspx
Mesenteric lymphadenitis reflects the mesenteric lymph node (MLN) response to an underlying infection of uncertain etiology, usually viral. […] In the pediatric population, nonspecific mesenteric adenitis (often viral in origin) is the most common finding in a large proportion of cases of medical pain abdomen seen in clinical practice. […] Mesenteric adenitis is usually viral in origin and has self-limiting course. […] Mesenteric adenitis and postviral gastritis have a very certain occurrence following an acute viral infection. […] MLN enlargement can be due to a primary etiology or else can be secondarily attributed to other causes such as infective etiology, malignancy, and inflammatory bowel diseases. […] In many children, no organic cause for recurrent abdominal pain can be established, and even when an abnormality is detected, it may be difficult to link the finding to the abdominal pain.
- #1 Mesenteric Lymphadenitis: Symptoms, Causes, Tests and Treatmentshttps://my.clevelandclinic.org/health/diseases/17890-mesenteric-lymphadenitis
Mesenteric lymphadenitis is inflammation (swelling) of the lymph nodes in the abdomen (belly). […] Swollen (inflamed) lymph nodes in the abdomen cause mesenteric lymphadenitis. Lymph nodes can swell because of an infection or they could be a symptom of a condition that causes inflammation. […] An infection by a virus or bacteria usually causes mesenteric lymphadenitis. Infections that could cause mesenteric lymphadenitis include: Gastroenteritis (sometimes called the stomach flu). […] If the mesenteric lymphadenitis is the result of a virus, then the virus itself may be contagious. […] Inflammation in your child’s abdominal lymph nodes could be the result of another condition that creates another part of your body to swell including: Appendicitis. […] Mesenteric lymphadenitis is common in children and teenagers. It usually doesn’t occur in adults or people over 20 years old. […] Mesenteric lymphadenitis is rare. The exact rate of occurrence is unknown because many cases resolve on their own and don’t need treatment.
- #1 Relationship Between Mesenteric Lymphadenitis and SIRS – Advanced Radiology and Imaginghttps://advradiology.org/articles/relationship-between-mesenteric-lymphadenitis-and-sirs/doi/AdvRadiolImaging.galenos.2024.35220
Mesenteric lymphadenitis is a condition characterized by inflammation of the lymph nodes in the mesentery. Systemic inflammatory response syndrome (SIRS) is a clinical response to a non-specific insult, which can be caused by various factors such as infection, trauma, burns, or other severe bodily stresses. […] Mesenteric lymphadenitis is usually caused by bacterial or viral infections and is more common in children and young adults. […] While it is important to consider the potential relationship between mesenteric lymphadenitis and SIRS, it is also crucial to acknowledge that not all cases of mesenteric lymphadenitis lead to SIRS. […] The inflammatory response in mesenteric lymphadenitis tends to be contained within the abdominal area and may not always meet the criteria for a systemic inflammatory response. […] Although mesenteric lymphadenitis and SIRS are primarily distinct conditions, their intersection in clinical scenarios underscores the importance of vigilant assessment and management to prevent potentially life-threatening complications.
- #2 Mesenteric Adenitis: Symptoms, Causes, Diagnosis, and Treatmenthttps://www.verywellhealth.com/mesenteric-adenitis-7375956
Mesenteric adenitis, also known as mesenteric lymphadenitis, is a secondary syndrome caused by inflammation of the lymph nodes found in a membrane fold that joins the intestines to the abdominal wall, known as the mesentery. […] Primary mesenteric adenitis is idiopathic, meaning it develops for no known reason. When there are no abnormalities or heightened levels of inflammation in the abdomen causing the symptoms of mesenteric adenitis, it is considered primary. […] Secondary, on the other hand, can be caused by a variety of factors, including: Inflammatory bowel diseases (IBD, including Crohn’s disease and ulcerative colitis), Chronic inflammatory diseases such as sarcoidosis and systemic lupus erythematosus (lupus), Human immunodeficiency virus (HIV), Tuberculosis (serious illness mainly affecting the lungs), Infections such as mononucleosis (viral infection causing fever, sore throat, and swollen lymph glands), salmonella poisoning (bacterial infection caused by eating raw or undercooked meat and certain other foods), and yersiniosis (bacterial infection caused by eating raw or undercooked pork), Viral infections that cause inflammation of the ileum, which sits at the lowermost part of the small intestine, Typhoid fever (or enteric fever, an illness caused by Salmonella bacteria), Stomach flu (viral gastroenteritis). […] These infections cause the lymph nodes to swell when the body tries to filter them out of its system.
- #2 What Is Mesenteric Lymphadenitis? – Klarity Health Libraryhttps://my.klarity.health/what-is-mesenteric-lymphadenitis/
Mesenteric lymphadenitis is usually caused by a viral infection. […] Mesenteric lymphadenitis can be divided into either primary or secondary types. Primary mesenteric lymphadenitis is an inflammation of lymph nodes without an identifiable cause. Whereas, secondary mesenteric lymphadenitis is associated with a detectable cause such as an infection. Yersinia enterocolitica (a bacteria found in raw or undercooked meat) is considered the main causative organism for secondary mesenteric lymphadenitis if caused by infection. […] Other secondary causes of Mesenteric Lymphadenitis include: Infection in the digestive tract, for example, a gastroenteritis infection caused by rotavirus or norovirus, can cause inflammation in the lymph nodes of the mesentery. E. coli. Inflammatory bowel diseases- such as ulcerative colitis and Crohn’s disease. Salmonella. Tuberculosis. Appendicitis. HIV infection.
- #2 What Is Mesenteric Adenitis?https://www.icliniq.com/articles/gastro-health/mesenteric-adenitis
Mesenteric adenitis refers to the swelling of lymph nodes in the abdomen. […] The leading cause of mesenteric adenitis is listed down: Viral infections include gastroenteritis (inflammation of intestinal linings) or stomach flu. […] Bacterial species like Yersinia pseudotuberculosis and Yersinia enterocolitica commonly cause mesenteric adenitis. And other species like E.coli, Salmonella, and Streptococcus are also found to cause inflammation of mesenteric lymph nodes. […] Mesenteric adenitis is classified according to the causative factor as follows: Primary Mesenteric Adenitis: It is the swelling of lymph nodes that occurs due to an unknown cause. […] Secondary Mesenteric Adenitis: Mesenteric adenitis occurs in response to the inflammation of intra-abdominal organs (gallbladder, pancreas, bile duct, etc.) due to any bacterial or viral infection.
- #2 Mesenteric lymphadenitis | Altru Health Systemhttps://www.altru.org/health-library/conditions/mesenteric-lymphadenitis
An infection in the intestines, such as a virus, is the usual cause of mesenteric lymphadenitis. […] The most common cause of mesenteric lymphadenitis is a viral infection, such as gastroenteritis. Gastroenteritis is often called stomach flu. This infection causes inflammation and swelling in the lymph nodes in the thin tissue that attaches the intestine to the back of the wall around the stomach area, called mesentery. […] Other causes of mesenteric lymphadenitis include bacterial infection, inflammatory bowel disease and lymphoma.
- #2 Mesenteric Lymphadenitis: Causes, Symptoms, and Treatmenthttps://www.webmd.com/children/mesenteric-lymphadentitis?page
Mesenteric lymphadenitis is an inflammation of lymph nodes. The most common cause is infection, such as a viral or bacterial stomach bug. […] Infections that cause mesenteric lymphadenitis may be located in one place (local) or throughout the body (systemic). The infections may be caused by: Viruses, Bacteria, Parasites. […] Common infections that cause mesenteric lymphadenitis include: Gastroenteritis. This may result from viral infections such as rotavirus or norovirus. It may also result from bacterial infections such as salmonella, staphylococcus, or streptococcus. […] Yersinia enterocolitica. This is the most common cause of mesenteric lymphadenitis in children. This bacteria, found in undercooked meat, can cause gastroenteritis and other problems. […] Other infections that cause mesenteric lymphadenitis include: Direct or indirect infections related to HIV. This is the virus that can lead to AIDS.
- #2https://www.ijpediatrics.com/index.php/ijcp/article/view/284
The aim was to study the clinical profile and causes of mesenteric lymphadenitis in children. […] The commonest cause of mesenteric lymphadenitis was found to be respiratory tract infection in 36.8% of patients followed by diarrhea 28%, urinary tract infection 12.2%, worm infestations 10.5%, enteric fever 7%, gastritis 5.2%.
- #2 Mesenteric adenitis | Radiology Reference Article | Radiopaedia.orghttps://radiopaedia.org/articles/mesenteric-adenitis?lang=us
Mesenteric adenitis (rare plural: adenitides), less commonly called mesenteric lymphadenitis (rare plural: lymphadenitides), is a self-limiting inflammatory process that affects the mesenteric lymph nodes in the right lower quadrant and is clinically often thought initially to be acute appendicitis, a common diagnostic mimic. […] The pathogenic micro-organisms are thought to gain access via intestinal lymphatics and then multiply in mesenteric lymph nodes. […] Mesenteric adenitis has a number of causes: variety of viruses, including Epstein-Barr virus and probably COVID-19, Yersinia enterocolitica, Helicobacter jejuni, Campylobacter jejuni, Salmonella spp., Shigella spp., Mycobacterium tuberculosis. […] Yersinia enterocolitica is considered the most common pathogen in temperate Europe, North America and Australia.
- #2 Mesenteric Lymphadenitis: Causes, Symptoms And Treatmenthttps://www.netmeds.com/health-library/post/mesenteric-lymphadenitis-causes-symptoms-and-treatment?srsltid=AfmBOoqJWpFcHIILO4091ZwlQ_FXolZCMJGuNjeGaaXDQD1EIhj9Kp9v
Parasite: Giardia lamblia […] Bacteria: Escherichia coli, Mycobacterium tuberculosis, Staphylococcus species, Streptococcus viridans, Yersinia enterocolitica, Bartonella henselae, Beta-hemolytic streptococci […] Virus: Adenoviruses, acute HIV infection, Epstein-Barr virus, Co Sackie viruses, Rubeola virus (measles) […] In some very rare cases, inflamed mesenteric lymph nodes can result from cancer, including: […] Lymphoma […] Lung cancer […] Pancreatic cancer […] Gastrointestinal cancer […] Breast cancer. […] Certain causative factors that increase the risk of Mesenteric lymphadenitis include: […] Stomach Flu: An infection due to a stomach virus increases the risk of getting mesenteric lymphadenitis as well. […] Respiratory infection: An infection of the upper respiratory tract due to the common cold virus can also aggravate the chances of mesenteric lymphadenitis. […] Undercooked Food: Eating undercooked pork contaminated with Y. enterocolitica can make a person prone to mesenteric lymphadenitis.
- #2 Mesenteric adenitis – symptoms, treatment | healthdirecthttps://www.healthdirect.gov.au/mesenteric-adenitis
Mesenteric adenitis is usually caused by a viral infection, but sometimes it’s caused by a bacterial infection or your health team may not know the cause. […] Mesenteric adenitis is most often caused by a virus. The infection (germ) can start anywhere, but it usually comes from having a cold or a bowel infection. […] It can also be caused by bacterial infections such as yersinia. These bacteria are found in food or water contaminated by human or animal faeces (poo). […] Sometimes the cause is not known.
- #2 Mesenteric Adenitis: Causes, Symptoms, and How Itâs Treatedhttps://www.medicoverhospitals.in/diseases/mesenteric-adenitis/
Inflammatory conditions such as Crohn’s disease or ulcerative colitis may result in mesenteric adenitis as a secondary response to the underlying inflammation. […] Parasitic infections like Giardia or Cryptosporidium can lead to mesenteric adenitis by affecting the lymphoid tissue in the mesentery of the abdomen.
- #2 What Causes Mesenteric Lymphadenitis? Swollen Lymph Nodeshttps://www.medicinenet.com/what_causes_mesenteric_lymphadenitis/article.htm
Inflammatory conditions commonly linked to mesenteric lymphadenitis are: Appendicitis (inflammation of the appendix) […] Inflammatory bowel diseases, such as Crohns disease or ulcerative colitis […] Connective tissue diseases, such as lupus, sclerosis, or rheumatoid arthritis […] Diverticulitis (inflammation of the lining of the large intestine) […] Pancreatitis (inflammation of the pancreas).
- #2 Mesenteric Lymphadenitishttps://www.medicalparkinternational.com/mesenteric-lymphadenitis
Infections of the gastrointestinal tract can spread to the mesenteric lymph nodes if they start in the intestines, appendix, or other adjacent abdominal organs. These infections may be parasitic, bacterial, or even viral in origin. […] In some instances, mesenteric lymphadenitis may be connected to underlying inflammatory disorders like Crohn’s disease or ulcerative colitis. […] Occasionally, respiratory infections brought on by particular bacteria or viruses might result in a reactive inflammatory reaction in the mesenteric lymph nodes. […] Though uncommon, certain lymphoma (lymphatic system cancer) subtypes might affect the mesenteric lymph nodes and result in lymphadenitis.
- #2 Mesenteric Adenitis – TeachMePaediatricshttps://teachmepaediatrics.com/gastroenterology/lower-gi/mesenteric-adenitis/
Mesenteric adenitis, also known as mesenteric lymphadenitis, is inflammation of lymph nodes found in the mesentery. Typically, this condition presents in children or young adults (1). Mesenteric adenitis can be primary or secondary in nature. Primary is thought to be lymphadenopathy without an obvious underlying inflammatory cause found. Secondary mesenteric adenitis is due to other underlying inflammatory conditions. This can be subdivided into acute or chronic (2): […] The cause for this lymphadenopathy is usually not found in primary mesenteric adenitis (1) but it is thought to occur after a recent viral or bacterial infection. Some of the organisms implicated in causing mesenteric adenitis are as follows (3): […] These organisms are thought to be ingested orally, cause gastroenteritis, and travel into the mesenteric lymph nodes, which results in localized inflammatory changes (1,3)
- #2https://journals.lww.com/jmsc/fulltext/2023/25010/relevance_of_mesenteric_lymphadenopathy_in.17.aspx
Due to shortcomings such as unreliable history and unpredictable clinical findings in pediatric age group, this often poses a diagnostic challenge. […] There is no standardized reference interval of MLN size in asymptomatic children, and the diagnostic criterion currently used for MLN enlargement has been controversial. […] It is also proposed to revise and lay down the cutoff limit for determining upon enlargement of mesenteric nodes as significant to 8 mm measured in short axis, to cut down upon the false-positive cases.
- #2 Mesenteric Adenitis Physician – Cancer Therapy Advisorhttps://www.cancertherapyadvisor.com/home/decision-support-in-medicine/hospital-medicine/mesenteric-adenitis-physician/
Right lower quadrant (RLQ) pain is a common initial presenting complaint with acute appendicitis as the most frequent cause. Mesenteric adenitis, also known as mesenteric lymphadenitis, is caused by inflamed mesenteric lymph nodes and is the second most common cause of acute RLQ abdominal pain. […] Primary mesenteric adenitis is usually a self-limited disease, caused by both viruses and bacteria. […] Primary mesenteric adenitis has various causes with a large number of cases due to Yersina enterocolitica or Yersina pseudotuberculosis. However, cases have been reported due to Mycobacterium tuberculosis, Staphlococcus aureus, beta hemolytic Streptococcus, Parvovirus B19, HIV, and rarely, Cryptococcus. […] Secondary mesenteric adenitis is defined as lymphadenitis associated with an underlying inflammatory process such as Crohns disease, systemic lupus erythematosous, and diverticulitis.
- #2https://journals.lww.com/jmsc/fulltext/2023/25010/relevance_of_mesenteric_lymphadenopathy_in.17.aspx
Mesenteric lymphadenitis reflects the mesenteric lymph node (MLN) response to an underlying infection of uncertain etiology, usually viral. […] In the pediatric population, nonspecific mesenteric adenitis (often viral in origin) is the most common finding in a large proportion of cases of medical pain abdomen seen in clinical practice. […] Mesenteric adenitis is usually viral in origin and has self-limiting course. […] Mesenteric adenitis and postviral gastritis have a very certain occurrence following an acute viral infection. […] MLN enlargement can be due to a primary etiology or else can be secondarily attributed to other causes such as infective etiology, malignancy, and inflammatory bowel diseases. […] In many children, no organic cause for recurrent abdominal pain can be established, and even when an abnormality is detected, it may be difficult to link the finding to the abdominal pain.
- #3 Mesenteric Lymphadenitis: Symptoms, Causes, Tests and Treatmentshttps://my.clevelandclinic.org/health/diseases/17890-mesenteric-lymphadenitis
Mesenteric lymphadenitis is inflammation (swelling) of the lymph nodes in the abdomen (belly). […] Swollen (inflamed) lymph nodes in the abdomen cause mesenteric lymphadenitis. Lymph nodes can swell because of an infection or they could be a symptom of a condition that causes inflammation. […] An infection by a virus or bacteria usually causes mesenteric lymphadenitis. Infections that could cause mesenteric lymphadenitis include: Gastroenteritis (sometimes called the stomach flu). […] If the mesenteric lymphadenitis is the result of a virus, then the virus itself may be contagious. […] Inflammation in your child’s abdominal lymph nodes could be the result of another condition that creates another part of your body to swell including: Appendicitis. […] Mesenteric lymphadenitis is common in children and teenagers. It usually doesn’t occur in adults or people over 20 years old. […] Mesenteric lymphadenitis is rare. The exact rate of occurrence is unknown because many cases resolve on their own and don’t need treatment.
- #3 Mesenteric Adenitis Physician – Cancer Therapy Advisorhttps://www.cancertherapyadvisor.com/home/decision-support-in-medicine/hospital-medicine/mesenteric-adenitis-physician/
Right lower quadrant (RLQ) pain is a common initial presenting complaint with acute appendicitis as the most frequent cause. Mesenteric adenitis, also known as mesenteric lymphadenitis, is caused by inflamed mesenteric lymph nodes and is the second most common cause of acute RLQ abdominal pain. […] Primary mesenteric adenitis is usually a self-limited disease, caused by both viruses and bacteria. […] Primary mesenteric adenitis has various causes with a large number of cases due to Yersina enterocolitica or Yersina pseudotuberculosis. However, cases have been reported due to Mycobacterium tuberculosis, Staphlococcus aureus, beta hemolytic Streptococcus, Parvovirus B19, HIV, and rarely, Cryptococcus. […] Secondary mesenteric adenitis is defined as lymphadenitis associated with an underlying inflammatory process such as Crohns disease, systemic lupus erythematosous, and diverticulitis.
- #3 Mesenteric Adenitis: Symptoms, Causes, and Treatmenthttps://patient.info/digestive-health/mesenteric-adenitis
Mesenteric adenitis means swollen (inflamed) lymph glands in the tummy (abdomen), which causes tummy pain. It is sometimes called mesenteric lymphadenitis. […] The most common cause of mesenteric lymphadenitis is a viral infection, such as gastroenteritis. A germ (infection) triggers the inflammation and swelling in the lymph glands. […] Less often, it may be a bacterial infection that is the cause – for example, a bacterial infection in the intestine. The inflamed glands then cause pain, tenderness and a high temperature (fever). […] It can also be caused by inflammatory bowel disease (IBD).
- #3 Mesenteric Lymphadenitishttps://www.medicalparkinternational.com/mesenteric-lymphadenitis
Mesenteric Lymphadenitis is an illness that develops as a subsequent reaction to a digestive system infection primarily brought on by viral or bacterial pathogens. The mesenteric lymph nodes in the area typically become inflamed due to the infection’s origin in the intestines, appendix, or other surrounding abdominal organs. […] Mesenteric lymphadenitis frequently results from viral infections. Common viruses linked to this condition include rotavirus, adenovirus, and Epstein-Barr virus (EBV). The inflammation from these diseases can spread to the digestive tract, the respiratory system, or other areas of the body. […] Specific bacterial infections can bring on mesenteric lymphadenitis. One famous instance is the bacterium Yersinia enterocolitica, which can cause appendicitis-like symptoms, gastrointestinal disorders, and inflammation of the mesenteric lymph nodes.
- #3 Mesenteric Adenitis: Symptoms, Causes, and Morehttps://www.healthline.com/health/childrens-health/mesenteric-adenitis
Mesenteric adenitis is a condition that more often affects children and teenagers. […] Another name for mesenteric adenitis is mesenteric lymphadenitis. […] A bout of the stomach flu or another infection in your abdomen can cause inflamed and swollen lymph nodes in and around the mesentery. […] Bacteria, viruses, and parasites can cause this condition. […] Mesenteric adenitis is often seen after viral gastroenteritis, also called the stomach flu. […] Some kids get mesenteric adenitis from eating undercooked pork thats been contaminated with the bacterium Yersinia enterocolitica.
- #3 Mesenteric Adenitis – StatPearls – NCBI Bookshelfhttps://www.ncbi.nlm.nih.gov/sites/books/NBK560822/
Mesenteric adenitis is a syndrome characterized by right lower quadrant pain secondary to an inflammatory condition of mesenteric lymph nodes. […] The etiologies of mesenteric adenitis include several causes of inflammatory response within mesenteric lymph nodes. These include viral infections, bacterial infections, inflammatory bowel disease, or lymphoma. Two common gram-negative bacteria that are known to cause mesenteric adenitis include Yersinia pseudotuberculosis and Yersinia enterocolitica. […] Other known culprits include salmonella, E coli, and streptococci. The etiology can further classify as primary versus secondary. Primary etiology occurs when the lymphadenopathy is the result of an unidentifiable inflammatory process. Secondary mesenteric adenitis occurs secondary to an intra-abdominal inflammatory process with a known source or etiology.
- #3 Mesenteric Adenitis: Symptoms, Causes, Diagnosis, and Treatmenthttps://www.verywellhealth.com/mesenteric-adenitis-7375956
Mesenteric adenitis, also known as mesenteric lymphadenitis, is a secondary syndrome caused by inflammation of the lymph nodes found in a membrane fold that joins the intestines to the abdominal wall, known as the mesentery. […] Primary mesenteric adenitis is idiopathic, meaning it develops for no known reason. When there are no abnormalities or heightened levels of inflammation in the abdomen causing the symptoms of mesenteric adenitis, it is considered primary. […] Secondary, on the other hand, can be caused by a variety of factors, including: Inflammatory bowel diseases (IBD, including Crohn’s disease and ulcerative colitis), Chronic inflammatory diseases such as sarcoidosis and systemic lupus erythematosus (lupus), Human immunodeficiency virus (HIV), Tuberculosis (serious illness mainly affecting the lungs), Infections such as mononucleosis (viral infection causing fever, sore throat, and swollen lymph glands), salmonella poisoning (bacterial infection caused by eating raw or undercooked meat and certain other foods), and yersiniosis (bacterial infection caused by eating raw or undercooked pork), Viral infections that cause inflammation of the ileum, which sits at the lowermost part of the small intestine, Typhoid fever (or enteric fever, an illness caused by Salmonella bacteria), Stomach flu (viral gastroenteritis). […] These infections cause the lymph nodes to swell when the body tries to filter them out of its system.
- #3 Lymphadenitis: Symptoms, types, and morehttps://www.medicalnewstoday.com/articles/lymphadenitis
Lymphadenitis occurs when bacteria, viruses, or fungi reach the lymph nodes, causing infection. […] Sometimes, lymphadenitis may resolve without treatment. This often occurs with mesenteric lymphadenitis, which refers to swollen lymph nodes in the abdomen.
- #4 Mesenteric Lymphadenitis: Causes, Symptoms And Treatmenthttps://www.netmeds.com/health-library/post/mesenteric-lymphadenitis-causes-symptoms-and-treatment?srsltid=AfmBOoqJWpFcHIILO4091ZwlQ_FXolZCMJGuNjeGaaXDQD1EIhj9Kp9v
Parasite: Giardia lamblia […] Bacteria: Escherichia coli, Mycobacterium tuberculosis, Staphylococcus species, Streptococcus viridans, Yersinia enterocolitica, Bartonella henselae, Beta-hemolytic streptococci […] Virus: Adenoviruses, acute HIV infection, Epstein-Barr virus, Co Sackie viruses, Rubeola virus (measles) […] In some very rare cases, inflamed mesenteric lymph nodes can result from cancer, including: […] Lymphoma […] Lung cancer […] Pancreatic cancer […] Gastrointestinal cancer […] Breast cancer. […] Certain causative factors that increase the risk of Mesenteric lymphadenitis include: […] Stomach Flu: An infection due to a stomach virus increases the risk of getting mesenteric lymphadenitis as well. […] Respiratory infection: An infection of the upper respiratory tract due to the common cold virus can also aggravate the chances of mesenteric lymphadenitis. […] Undercooked Food: Eating undercooked pork contaminated with Y. enterocolitica can make a person prone to mesenteric lymphadenitis.
- #4 Mesenteric adenitis | Radiology Reference Article | Radiopaedia.orghttps://radiopaedia.org/articles/mesenteric-adenitis?lang=us
Mesenteric adenitis (rare plural: adenitides), less commonly called mesenteric lymphadenitis (rare plural: lymphadenitides), is a self-limiting inflammatory process that affects the mesenteric lymph nodes in the right lower quadrant and is clinically often thought initially to be acute appendicitis, a common diagnostic mimic. […] The pathogenic micro-organisms are thought to gain access via intestinal lymphatics and then multiply in mesenteric lymph nodes. […] Mesenteric adenitis has a number of causes: variety of viruses, including Epstein-Barr virus and probably COVID-19, Yersinia enterocolitica, Helicobacter jejuni, Campylobacter jejuni, Salmonella spp., Shigella spp., Mycobacterium tuberculosis. […] Yersinia enterocolitica is considered the most common pathogen in temperate Europe, North America and Australia.
- #5 Briefs: Mesenteric Lymphadenitis – A cause of pain or an excuse? – PEMBloghttps://pemcincinnati.com/blog/briefs-mesenteric-lymphadenitis-cause-pain-excuse/
Mesenteric LAN is more common in children and adolescents overall, and can be precipitated by a number of causes including gastroenteritis, inflammatory bowel disease and appendicitis. […] It also appears to have an association with Yersinia, so find out if your patient has been eating raw pork. […] The list of specific etiologies is long, including beta-hemolytic streptococcus, Staphylococcus species, Escherichia coli, Streptococcus viridans, Yersinia species (responsible for most cases currently), Mycobacterium tuberculosis, Giardia lamblia, and non Salmonella typhoid.