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• #1 9 Top Neuroendocrine Tumor Symptoms & Signs | MD Anderson Cancer Center

  https://www.mdanderson.org/cancer-types/neuroendocrine-tumors/neuroendocrine-tumor-symptoms.html

  Since neuroendcrine tumors (NETs) can form anywhere in the body, symptoms will vary depending on where the tumor is located. […] NETs can cause symptoms that are common to many cancers. These include: Fatigue, A new, growing lump or mass, Unexplained weight loss. […] Symptoms of gastrointestinal nets are similar to those of other GI tract cancers. These include: Rectal bleeding and/or blood in the stool, A change in size, shape or color of the stool, Discomfort or urge to have a bowel movement when there is no need, Bloating or a feeling of fullness, Unexplained weight loss, Pain in the abdomen or lower back. […] Many lung cancers are NETs. As such, their symptoms match general lung cancer symptoms. […] The symptoms of pancreatic NETs are similar to other pancreatic cancers. […] Functional NETs are NETs that produce hormones. Like all NETs, these can appear anywhere in the body. The hormones they release can cause physical symptoms and lead to changes in behavior. In addition to symptoms related to their location, the symptoms of functional NETs may include: Persistent flushing of the face, Persistent, often severe diarrhea, Severe gastric ulcers, High blood sugar or low blood sugar, Changes in bathroom habits, including diarrhea and frequent urination, Dizziness or shakiness, Anxiety or confusion.

• #1 Neuroendocrine tumors – Symptoms and causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/neuroendocrine-tumors/symptoms-causes/syc-20354132

  Neuroendocrine tumors don’t always cause signs and symptoms at first. The symptoms you might experience depend on the location of your tumor and whether it produces excess hormones. […] In general, neuroendocrine tumor signs and symptoms might include: Pain from a growing tumor, A growing lump you can feel under the skin, Feeling unusually tired, Losing weight without trying. […] Neuroendocrine tumors that produce excess hormones (functional tumors) might cause: Skin flushing, Diarrhea, Frequent urination, Increased thirst, Dizziness, Shakiness, Skin rash. […] Some neuroendocrine tumors grow very slowly. Others are aggressive cancers that invade and destroy normal body tissue or spread (metastasize) to other parts of the body.

• #2 Neuroendocrine Tumors (NETs): Symptoms & Treatment

  https://my.clevelandclinic.org/health/diseases/22006-neuroendocrine-tumors-net

  Neuroendocrine tumors (NETs) are a group of uncommon tumors that start in specialized cells in your neuroendocrine system. They’re most common in your GI tract, lungs and pancreas but can form wherever neuroendocrine cells are in your body. Early diagnosis and treatment continue to increase the number of people living for years with NET. […] Often, neuroendocrine tumors don’t cause symptoms until a tumor impacts an organ. When this happens, symptoms vary based on location. NET symptoms may include: Fatigue. Stomach pain. Diarrhea. Nausea and vomiting. Shortness of breath. Coughing (sometimes with blood). […] Carcinoid syndrome happens when a neuroendocrine tumor in your GI tract or lungs releases too many hormones. It can cause a range of unpleasant symptoms, including flushing (sudden warmth and redness) of your head and neck, wheezing and diarrhea.

• #2 9 Top Neuroendocrine Tumor Symptoms & Signs | MD Anderson Cancer Center

  https://www.mdanderson.org/cancer-types/neuroendocrine-tumors/neuroendocrine-tumor-symptoms.html

  Since neuroendcrine tumors (NETs) can form anywhere in the body, symptoms will vary depending on where the tumor is located. […] NETs can cause symptoms that are common to many cancers. These include: Fatigue, A new, growing lump or mass, Unexplained weight loss. […] Symptoms of gastrointestinal nets are similar to those of other GI tract cancers. These include: Rectal bleeding and/or blood in the stool, A change in size, shape or color of the stool, Discomfort or urge to have a bowel movement when there is no need, Bloating or a feeling of fullness, Unexplained weight loss, Pain in the abdomen or lower back. […] Many lung cancers are NETs. As such, their symptoms match general lung cancer symptoms. […] The symptoms of pancreatic NETs are similar to other pancreatic cancers. […] Functional NETs are NETs that produce hormones. Like all NETs, these can appear anywhere in the body. The hormones they release can cause physical symptoms and lead to changes in behavior. In addition to symptoms related to their location, the symptoms of functional NETs may include: Persistent flushing of the face, Persistent, often severe diarrhea, Severe gastric ulcers, High blood sugar or low blood sugar, Changes in bathroom habits, including diarrhea and frequent urination, Dizziness or shakiness, Anxiety or confusion.

• #3 Delays and routes to diagnosis of neuroendocrine tumours | BMC Cancer | Full Text

  https://bmccancer.biomedcentral.com/articles/10.1186/s12885-018-5057-3

  Neuroendocrine tumours are uncommon tumours; there is often a long period between the onset of symptoms and diagnosis. This study aims to address the symptoms prior to diagnosis of people with known neuroendocrine tumours and also the involvement of healthcare providers prior to the diagnosis. […] The results demonstrated a median time from first symptom to diagnosis of 53.8 months. The most frequent initial symptoms were of pain, change in bowel habit and fatigue. 31% of respondents noted weight loss prior to diagnosis. […] In conclusion, there is a long time from onset of symptoms to diagnosis in all types of NETs. This is despite many respondents having alarm symptoms at diagnosis. Further education and awareness regarding malignancy may help with earlier diagnosis. […] The mean duration of the first symptom prior to diagnosis for respondents was 53.8 months overall, 60.1 months for small bowel NETs (sbNETs), 39.1 months for pancreatic NETs (pNETs) and 67.7 months for lung NETs.

• #4 Delays and routes to diagnosis of neuroendocrine tumours | BMC Cancer | Full Text

  https://bmccancer.biomedcentral.com/articles/10.1186/s12885-018-5057-3

  80% of respondents reported that they had symptoms prior to diagnosis (243/303). Most of these respondents reported that their symptoms led to the NET diagnosis (73%, 221/303), in particular those with pNETs (73%, 47/64) and small bowel NETs (83%, 82/99). […] The time from first symptom to diagnosis was 53.8 months, which is a very long time especially when considering the number of respondents that regarded their primary symptom as being severe or very severe in nature. A significant delay is likely to be occurring due to incorrect initial diagnosis. […] The survey has clearly demonstrated that the majority of respondents with NETs do not present with typical symptoms. […] In summary, this survey demonstrates a mean time of 53.8 months from onset of symptoms to diagnosis. The primary symptoms from respondents appear linked to the primary site of the tumour and associated weight loss is a common finding. Respondents are seeking healthcare but are often misdiagnosed with functional gastrointestinal disorders.

• #5 Neuroendocrine tumors – Symptoms and causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/neuroendocrine-tumors/symptoms-causes/syc-20354132

  Neuroendocrine tumors don’t always cause signs and symptoms at first. The symptoms you might experience depend on the location of your tumor and whether it produces excess hormones. […] In general, neuroendocrine tumor signs and symptoms might include: Pain from a growing tumor, A growing lump you can feel under the skin, Feeling unusually tired, Losing weight without trying. […] Neuroendocrine tumors that produce excess hormones (functional tumors) might cause: Skin flushing, Diarrhea, Frequent urination, Increased thirst, Dizziness, Shakiness, Skin rash. […] Some neuroendocrine tumors grow very slowly. Others are aggressive cancers that invade and destroy normal body tissue or spread (metastasize) to other parts of the body.

• #6 9 Top Neuroendocrine Tumor Symptoms & Signs | MD Anderson Cancer Center

  https://www.mdanderson.org/cancer-types/neuroendocrine-tumors/neuroendocrine-tumor-symptoms.html

  Since neuroendcrine tumors (NETs) can form anywhere in the body, symptoms will vary depending on where the tumor is located. […] NETs can cause symptoms that are common to many cancers. These include: Fatigue, A new, growing lump or mass, Unexplained weight loss. […] Symptoms of gastrointestinal nets are similar to those of other GI tract cancers. These include: Rectal bleeding and/or blood in the stool, A change in size, shape or color of the stool, Discomfort or urge to have a bowel movement when there is no need, Bloating or a feeling of fullness, Unexplained weight loss, Pain in the abdomen or lower back. […] Many lung cancers are NETs. As such, their symptoms match general lung cancer symptoms. […] The symptoms of pancreatic NETs are similar to other pancreatic cancers. […] Functional NETs are NETs that produce hormones. Like all NETs, these can appear anywhere in the body. The hormones they release can cause physical symptoms and lead to changes in behavior. In addition to symptoms related to their location, the symptoms of functional NETs may include: Persistent flushing of the face, Persistent, often severe diarrhea, Severe gastric ulcers, High blood sugar or low blood sugar, Changes in bathroom habits, including diarrhea and frequent urination, Dizziness or shakiness, Anxiety or confusion.

• #7 Identify Symptoms and Signs of Neuroendocrine Tumors

  https://www.cancercenter.com/cancer-types/neuroendocrine-tumors/symptoms

  Different types of neuroendocrine tumors (NET) cause different symptoms, depending on the location of the tumor, and whether the NET is functional or nonfunctional. Functioning NETs are defined based on the presence of clinical symptoms due to excess hormone secretion by the tumor. Nonfunctional NETs do not secrete hormones. They may produce symptoms caused by the tumor’s growth. […] Common symptoms of NETs include: Flushing (redness, warmth) in the face or neck without sweating […] Diarrhea, including at nighttime […] Shortness of breath, rapid heartbeat/palpitations […] High blood pressure […] Fatigue, weakness […] Abdominal pain, cramping, feeling of fullness […] Unexplained weight gain or loss […] Wheezing, coughing […] Swelling in the feet and ankles […] Skin lesions, discolored patches of skin, thin skin […] High blood glucose levels (frequent urination, increased thirst, increased hunger) […] Low blood glucose levels (shakiness, dizziness, sweating, fainting).

• #8 Symptoms of neuroendocrine tumours (NETs) | Canadian Cancer Society

  https://cancer.ca/en/cancer-information/cancer-types/neuroendocrine-tumours/signs-and-symptoms

  Carcinoid syndrome is a group of symptoms caused by a NET releasing large amounts of serotonin and other chemicals into the blood. Carcinoid syndrome may happen in people with any type of NET. It most commonly occurs with NETs of the small intestine that have spread to the liver (liver metastases). The signs or symptoms of carcinoid syndrome include: flushing of the skin, mainly the face and neck, diarrhea, wheezing and difficulty breathing, fast or irregular heartbeat, low blood pressure, heart damage (carcinoid heart disease). […] Lung neuroendocrine tumours (lung NETs) usually develop in the airways (bronchi). Signs or symptoms of lung NETs may include: a cough that doesnt go away, coughing up blood, difficulty breathing, fatigue, pneumonia, carcinoid syndrome may include flushing of the skin, diarrhea and wheezing.

• #9 What are small bowel neuroendocrine cancers? | Cancer Research UK

  https://www.cancerresearchuk.org/about-cancer/neuroendocrine-tumours-nets/small-bowel-nets/symptoms

  Some small bowel neuroendocrine cancers make hormones that go into the bloodstream. Doctors call these functioning tumours. These hormones can cause symptoms. Doctors call this collection of symptoms carcinoid syndrome. It is more likely to happen if the cancer has spread to other parts of the body, especially the liver. […] The symptoms might include: flushing of your skin, diarrhoea, wheezing, fast heart beat.

• #10 Neuroendocrine tumours and identifying progression | RLTCare

  https://www.rltcare.novartis.com/explore-disease-areas/neuroendocrine-tumors/identifying-progression

  Potential symptoms of tumor progression include: Carcinoid syndrome (CS) […] Carcinoid crisis (CC) […] Carcinoid heart disease (CHD) […] Patients may also experience symptoms due to increased tumor burden or secretion of bioactive substances from functional tumors. […] Symptoms due to functional carcinoid tumors usually include: urinary symptoms, flushing, diarrhea, abdominal pain, wheezing, palpitations. […] Symptoms due to increased tumor burden usually include: weight loss, ascites, jaundice, bowel obstruction, palpitation of new or enlarged tumor or lymph node. […] The assessment of disease progression in individuals with GEP-NETs uses various radiological techniques such as computed tomography (CT) scans, magnetic resonance imaging (MRI) scans, somatostatin receptor (SSTR) imaging, and positron emission tomography (PET)/CT imaging.

• #11 Learn About Gastrointestinal Neuroendcrine Tumors – NETRF

  https://netrf.org/old-for-patients/nets-info/tumor-site/gi/

  Neuroendocrine tumor signs and symptoms in the rectum may include: […] Non-functional neuroendocrine tumors do not overproduce and secrete hormones into the bloodstream. This sometimes leads to a tumor growing for a long time without causing signs or symptoms. A large tumor, however, can causes sign or symptoms if it blocks parts of the GI tract. […] When a GI NET over produces and releases hormones into the bloodstream, the tumor is called a “functional” tumor. […] Signs and symptoms of carcinoid syndrome include: […] Carcinoid syndrome can lead to heart damage or heart disease. […] Some patients experience severe, sudden, even life-threatening symptoms, called a carcinoid crisis. A carcinoid crisis typically occurs during surgery, invasive procedures, or in times of severe stress, affecting a person’s blood pressure and heart rate.

• #12 Neuroendocrine cancers | healthdirect

  https://www.healthdirect.gov.au/neuroendocrine-cancers

  Neuroendocrine cancers usually dont cause symptoms at an early stage. […] You may experience general symptoms such as fatigue and loss of appetite, or symptoms related to where the tumour is. […] Some neuroendocrine cancers cause carcinoid syndrome, which is flushing of the face, diarrhoea, wheezing and shortness of breath. […] Many neuroendocrine cancers do not cause symptoms at an early stage. General symptoms include fatigue and loss of appetite. There are also many symptoms that you may experience depending on where the cancer is in your body and if it is releasing hormones into your bloodstream. These include: abdominal pain and bloating, bowel obstruction or bleeding from the anus, low blood sugar, nausea or vomiting, rashes, coughing up blood, chest pain. […] Carcinoid syndrome refers to a group of symptoms that may occur when neuroendocrine cancers or the lungs or gastrointestinal (GI) tract make too many hormones. […] Carcinoid syndrome symptoms include: flushing of the face, diarrhoea, wheezing, shortness of breath. […] Sometimes people with a neuroendocrine cancer have a severe episode of carcinoid syndrome triggered by stress, general anaesthetic or certain treatments. This is called a 'carcinoid crisis’.

• #13 Symptoms of neuroendocrine tumours (NETs) | Canadian Cancer Society

  https://cancer.ca/en/cancer-information/cancer-types/neuroendocrine-tumours/signs-and-symptoms

  Neuroendocrine tumours (NETs) may not cause any signs or symptoms if they grow slowly and dont make too much of a certain hormone. Signs and symptoms may appear as the tumour grows or if hormones are released by the tumour (if it is a functional tumour). Other health conditions can cause the same symptoms as NETs. […] The signs or symptoms of NETs vary depending on where the tumour develops in the body. […] Gastrointestinal neuroendocrine tumours (GI NETs) can develop in any part of the gastrointestinal tract, including the small or large intestine and stomach. Signs or symptoms of GI NETs may include: discomfort or pain in the abdomen or rectum, nausea and vomiting, diarrhea, bleeding from the rectum or blood in the stool, anemia may cause fatigue, heartburn or indigestion, stomach ulcers can cause heartburn, indigestion and pain in the chest or abdomen, weight loss, blockage in the intestine (bowel obstruction) may cause pain in the abdomen or constipation.

• #14 9 Top Neuroendocrine Tumor Symptoms & Signs | MD Anderson Cancer Center

  https://www.mdanderson.org/cancer-types/neuroendocrine-tumors/neuroendocrine-tumor-symptoms.html

  Since neuroendcrine tumors (NETs) can form anywhere in the body, symptoms will vary depending on where the tumor is located. […] NETs can cause symptoms that are common to many cancers. These include: Fatigue, A new, growing lump or mass, Unexplained weight loss. […] Symptoms of gastrointestinal nets are similar to those of other GI tract cancers. These include: Rectal bleeding and/or blood in the stool, A change in size, shape or color of the stool, Discomfort or urge to have a bowel movement when there is no need, Bloating or a feeling of fullness, Unexplained weight loss, Pain in the abdomen or lower back. […] Many lung cancers are NETs. As such, their symptoms match general lung cancer symptoms. […] The symptoms of pancreatic NETs are similar to other pancreatic cancers. […] Functional NETs are NETs that produce hormones. Like all NETs, these can appear anywhere in the body. The hormones they release can cause physical symptoms and lead to changes in behavior. In addition to symptoms related to their location, the symptoms of functional NETs may include: Persistent flushing of the face, Persistent, often severe diarrhea, Severe gastric ulcers, High blood sugar or low blood sugar, Changes in bathroom habits, including diarrhea and frequent urination, Dizziness or shakiness, Anxiety or confusion.

• #15 Identify Symptoms and Signs of Neuroendocrine Tumors

  https://www.cancercenter.com/cancer-types/neuroendocrine-tumors/symptoms

  NETs often dont cause symptoms early in the disease process. When symptoms are present, they may be similar to those caused by more common conditions. As a result, NETs are sometimes misdiagnosed as irritable bowel syndrome (IBS). However, with IBS, abdominal discomfort is usually relieved by going to the bathroom. […] As they grow larger, nonfunctional tumors that arent producing excess hormones may cause symptoms based on which nearby tissues and structures theyre affecting. […] A nonfunctional NET in the lung may produce symptoms similar to pneumonia, such as: Difficulty breathing […] Chest pain […] Wheezing. It may also lead to a bloody cough. […] These NETs may cause a variety of GI-related issues such as: Diarrhea […] Vomiting and nausea […] Constipation […] Abdominal pain […] Dark bowel movements caused by blood in the stool. They also may cause unexplained weight loss, a rash or fatigue.

• #16 Symptoms of neuroendocrine tumours (NETs) | Canadian Cancer Society

  https://cancer.ca/en/cancer-information/cancer-types/neuroendocrine-tumours/signs-and-symptoms

  Carcinoid syndrome is a group of symptoms caused by a NET releasing large amounts of serotonin and other chemicals into the blood. Carcinoid syndrome may happen in people with any type of NET. It most commonly occurs with NETs of the small intestine that have spread to the liver (liver metastases). The signs or symptoms of carcinoid syndrome include: flushing of the skin, mainly the face and neck, diarrhea, wheezing and difficulty breathing, fast or irregular heartbeat, low blood pressure, heart damage (carcinoid heart disease). […] Lung neuroendocrine tumours (lung NETs) usually develop in the airways (bronchi). Signs or symptoms of lung NETs may include: a cough that doesnt go away, coughing up blood, difficulty breathing, fatigue, pneumonia, carcinoid syndrome may include flushing of the skin, diarrhea and wheezing.

• #17 9 Top Neuroendocrine Tumor Symptoms & Signs | MD Anderson Cancer Center

  https://www.mdanderson.org/cancer-types/neuroendocrine-tumors/neuroendocrine-tumor-symptoms.html

  Since neuroendcrine tumors (NETs) can form anywhere in the body, symptoms will vary depending on where the tumor is located. […] NETs can cause symptoms that are common to many cancers. These include: Fatigue, A new, growing lump or mass, Unexplained weight loss. […] Symptoms of gastrointestinal nets are similar to those of other GI tract cancers. These include: Rectal bleeding and/or blood in the stool, A change in size, shape or color of the stool, Discomfort or urge to have a bowel movement when there is no need, Bloating or a feeling of fullness, Unexplained weight loss, Pain in the abdomen or lower back. […] Many lung cancers are NETs. As such, their symptoms match general lung cancer symptoms. […] The symptoms of pancreatic NETs are similar to other pancreatic cancers. […] Functional NETs are NETs that produce hormones. Like all NETs, these can appear anywhere in the body. The hormones they release can cause physical symptoms and lead to changes in behavior. In addition to symptoms related to their location, the symptoms of functional NETs may include: Persistent flushing of the face, Persistent, often severe diarrhea, Severe gastric ulcers, High blood sugar or low blood sugar, Changes in bathroom habits, including diarrhea and frequent urination, Dizziness or shakiness, Anxiety or confusion.

• #18 Neuroendocrine tumours | Cancer Council

  https://www.cancer.org.au/cancer-information/types-of-cancer/rare-cancers/neuroendocrine-tumours

  Symptoms may include: repeated pneumonia or chest infections, coughing up blood, shortness of breath; wheezing, chest pain. […] Symptoms may include: painless lump or swelling in the tummy, chest or neck, swollen legs, arms, upper chest, neck and face, loss of appetite or feeling full, weight loss, changes in bowel or bladder habits, difficulty breathing or swallowing, headaches or dizziness, drooping eyelid, trouble feeling or moving arms and legs.

• #19 Symptoms of neuroendocrine tumours (NETs) | Canadian Cancer Society

  https://cancer.ca/en/cancer-information/cancer-types/neuroendocrine-tumours/signs-and-symptoms

  Cushing syndrome is a group of symptoms caused by too much cortisol in the body. Cushing syndrome may happen in people with NETs, including some lung and pancreatic NETs, when too much adrenocorticotropic hormone (ACTH) is released. This causes too much cortisol to be made by the adrenal glands. The signs or symptoms of Cushing syndrome include: weight gain, a red, round and full face, muscle weakness, increased hair growth on the face and body, a buildup of fat between the shoulders or above the collar bone, purple lines on the skin, high blood pressure, high blood sugar (glucose) levels, changes in mood and behaviour. […] Signs or symptoms of pancreatic neuroendocrine tumours (pNETs) depend mainly on the type of hormone released by the tumour. The signs or symptoms of pNETs include: low blood sugar levels (hypoglycemia) may cause sweating, shakiness, dizziness, extreme hunger and problems concentrating, high blood sugar levels (hyperglycemia) may cause extreme thirst and frequent urination, diarrhea and fatty stools, stomach ulcers may cause heartburn, indigestion and pain in the chest or abdomen, weight loss, patches of red, itchy and painful skin, jaundice, blood clots, Cushing syndrome may include a red, round and full face.

• #20 Symptoms of Pancreatic Neuroendocrine Tumors – Pancreatic Cancer Action Network

  https://pancan.org/facing-pancreatic-cancer/symptoms/symptoms-of-neuroendocrine-tumors/

  Pancreatic neuroendocrine tumors (pancreatic NETs or PNETs), also called pancreatic endocrine tumors or islet cell tumors, are tumors that form from the abnormal growth of hormone-producing cells in the pancreas called islet cells. The pancreas produces hormones that regulate blood sugar level, stomach acid production, the rate of food absorption and amount of water in the intestines. Pancreatic neuroendocrine tumors are either functional (produce hormones) or nonfunctional (do not produce hormones). […] Functional pancreatic neuroendocrine tumors may cause the pancreas to overproduce certain hormones, resulting in a number of symptoms. The following table describes symptoms specific to functional pancreatic neuroendocrine tumors. […] Gastrinoma (Zollinger-Ellison Syndrome) gastrin Acid reflux, burning abdominal pain, diarrhea, excess fat in the stools and weight loss.

• #21 Symptoms of Pancreatic Neuroendocrine Tumors – Pancreatic Cancer Action Network

  https://pancan.org/facing-pancreatic-cancer/symptoms/symptoms-of-neuroendocrine-tumors/

  Glucaganoma glucagon High blood sugar, severe swelling or irritation of the skin, mouth sores, anemia and weight loss. […] Insulinoma insulin Low blood sugar, which can cause heart palpitations, shakiness, perspiration, confusion and seizures. […] Somatostatinoma somatostatin Because this hormone suppresses production of a variety of other hormones, symptoms are non-specific. They include diabetes, gallstones, weight loss, diarrhea, excess fat in the stools, nausea and vomiting. […] Vasoactive Intestinal Peptide Releasing Tumor (VIPoma) (Verner-Morrison Syndrome) vasoactive intestinal peptide (VIP) Severe watery diarrhea, which can lead to low blood potassium levels causing muscle weakness, fatigue and nausea. […] Nonfunctional pancreatic neuroendocrine tumors do not cause the pancreas to overproduce hormones. They are generally detected because of pain or jaundice caused by the large tumor size.

• #22 Symptoms of neuroendocrine tumours (NETs) | Canadian Cancer Society

  https://cancer.ca/en/cancer-information/cancer-types/neuroendocrine-tumours/signs-and-symptoms

  Zollinger-Ellison syndrome is a condition caused by too much gastrin in the body. This increases the amount of stomach acid made, which can eventually lead to ulcers of the stomach or small intestine. Zollinger-Ellison syndrome may happen in people with gastrin-producing NETs of the pancreas or small intestine (gastrinoma). The signs or symptoms of Zollinger-Ellison syndrome include: pain in the abdomen, severe diarrhea, heartburn, nausea and vomiting, sometimes vomiting blood, weight loss.

• #23 Symptoms of Pancreatic Neuroendocrine Tumors – Pancreatic Cancer Action Network

  https://pancan.org/facing-pancreatic-cancer/symptoms/symptoms-of-neuroendocrine-tumors/

  Pancreatic neuroendocrine tumors (pancreatic NETs or PNETs), also called pancreatic endocrine tumors or islet cell tumors, are tumors that form from the abnormal growth of hormone-producing cells in the pancreas called islet cells. The pancreas produces hormones that regulate blood sugar level, stomach acid production, the rate of food absorption and amount of water in the intestines. Pancreatic neuroendocrine tumors are either functional (produce hormones) or nonfunctional (do not produce hormones). […] Functional pancreatic neuroendocrine tumors may cause the pancreas to overproduce certain hormones, resulting in a number of symptoms. The following table describes symptoms specific to functional pancreatic neuroendocrine tumors. […] Gastrinoma (Zollinger-Ellison Syndrome) gastrin Acid reflux, burning abdominal pain, diarrhea, excess fat in the stools and weight loss.

• #24 Neuroendocrine tumors – Symptoms and causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/neuroendocrine-tumors/symptoms-causes/syc-20354132

  Neuroendocrine tumors don’t always cause signs and symptoms at first. The symptoms you might experience depend on the location of your tumor and whether it produces excess hormones. […] In general, neuroendocrine tumor signs and symptoms might include: Pain from a growing tumor, A growing lump you can feel under the skin, Feeling unusually tired, Losing weight without trying. […] Neuroendocrine tumors that produce excess hormones (functional tumors) might cause: Skin flushing, Diarrhea, Frequent urination, Increased thirst, Dizziness, Shakiness, Skin rash. […] Some neuroendocrine tumors grow very slowly. Others are aggressive cancers that invade and destroy normal body tissue or spread (metastasize) to other parts of the body.

• #25 Neuroendocrine tumours | Cancer Council

  https://www.cancer.org.au/cancer-information/types-of-cancer/rare-cancers/neuroendocrine-tumours

  Most neuroendocrine tumours develop slowly over several years but they can also be aggressive and grow quickly, spreading to other parts of the body and causing problems. […] In the early stages neuroendocrine tumours may not cause symptoms. If you do have symptoms, it will depend on where in the body the tumour is and if the tumour cells are producing hormones. You may experience general symptoms such as fatigue and loss of appetite. […] Symptoms may include: abdominal (tummy) pain and bloating, changes in bowel or bladder habits, including diarrhoea, bowel obstruction or bleeding from the anus, facial flushing and asthma-like wheezing. […] Symptoms may include: low blood sugar levels (hypoglycaemia) causing shaking, sweating, confusion, dizziness and rapid heartbeat, high blood sugar levels (hyperglycaemia) which may cause increased urination, excessive thirst and blurred vision, indigestion (heartburn) and stomach ulcers, rash in the groin area, unexplained weight loss, nausea or vomiting, changes in bowel habits, including diarrhoea or pale, foul-smelling stools that are hard to flush away.

• #26 Neuroendocrine Tumors: The Silent Cancer on the Rise – Breakthroughs in Diagnosis, Treatment, Survival and Latest 2025 Reaserches – OncoDaily

  https://oncodaily.com/oncolibrary/cancer-types/neuroendocrine-tumors

  One of the most important prognostic indicators is tumor grade. Low-grade NETs, which are slow-growing and well-differentiated, typically have a more favorable long-term outlook. In contrast, high-grade tumors such as poorly differentiated neuroendocrine carcinomas are more aggressive, associated with rapid progression and reduced survival. […] The stage at diagnosis also plays a crucial role. Patients diagnosed at an early stage, when the tumor is localized and potentially resectable, generally experience better survival outcomes. However, once the disease has metastasizedparticularly to the liver or bonethe prognosis becomes more guarded. […] Tumor location further influences prognosis. Pancreatic and gastrointestinal NETs often respond better to treatment and have longer survival rates, especially when diagnosed early. On the other hand, neuroendocrine tumors arising in the lungs, particularly large-cell and small-cell subtypes, tend to behave more aggressively and are associated with poorer outcomes.

• #27 Neuroendocrine Tumors: The Silent Cancer on the Rise – Breakthroughs in Diagnosis, Treatment, Survival and Latest 2025 Reaserches – OncoDaily

  https://oncodaily.com/oncolibrary/cancer-types/neuroendocrine-tumors

  One of the most important prognostic indicators is tumor grade. Low-grade NETs, which are slow-growing and well-differentiated, typically have a more favorable long-term outlook. In contrast, high-grade tumors such as poorly differentiated neuroendocrine carcinomas are more aggressive, associated with rapid progression and reduced survival. […] The stage at diagnosis also plays a crucial role. Patients diagnosed at an early stage, when the tumor is localized and potentially resectable, generally experience better survival outcomes. However, once the disease has metastasizedparticularly to the liver or bonethe prognosis becomes more guarded. […] Tumor location further influences prognosis. Pancreatic and gastrointestinal NETs often respond better to treatment and have longer survival rates, especially when diagnosed early. On the other hand, neuroendocrine tumors arising in the lungs, particularly large-cell and small-cell subtypes, tend to behave more aggressively and are associated with poorer outcomes.

• #28 Neuroendocrine Tumors: The Silent Cancer on the Rise – Breakthroughs in Diagnosis, Treatment, Survival and Latest 2025 Reaserches – OncoDaily

  https://oncodaily.com/oncolibrary/cancer-types/neuroendocrine-tumors

  One of the most important prognostic indicators is tumor grade. Low-grade NETs, which are slow-growing and well-differentiated, typically have a more favorable long-term outlook. In contrast, high-grade tumors such as poorly differentiated neuroendocrine carcinomas are more aggressive, associated with rapid progression and reduced survival. […] The stage at diagnosis also plays a crucial role. Patients diagnosed at an early stage, when the tumor is localized and potentially resectable, generally experience better survival outcomes. However, once the disease has metastasizedparticularly to the liver or bonethe prognosis becomes more guarded. […] Tumor location further influences prognosis. Pancreatic and gastrointestinal NETs often respond better to treatment and have longer survival rates, especially when diagnosed early. On the other hand, neuroendocrine tumors arising in the lungs, particularly large-cell and small-cell subtypes, tend to behave more aggressively and are associated with poorer outcomes.

• #29 Delays and routes to diagnosis of neuroendocrine tumours | BMC Cancer | Full Text

  https://bmccancer.biomedcentral.com/articles/10.1186/s12885-018-5057-3

  Neuroendocrine tumours are uncommon tumours; there is often a long period between the onset of symptoms and diagnosis. This study aims to address the symptoms prior to diagnosis of people with known neuroendocrine tumours and also the involvement of healthcare providers prior to the diagnosis. […] The results demonstrated a median time from first symptom to diagnosis of 53.8 months. The most frequent initial symptoms were of pain, change in bowel habit and fatigue. 31% of respondents noted weight loss prior to diagnosis. […] In conclusion, there is a long time from onset of symptoms to diagnosis in all types of NETs. This is despite many respondents having alarm symptoms at diagnosis. Further education and awareness regarding malignancy may help with earlier diagnosis. […] The mean duration of the first symptom prior to diagnosis for respondents was 53.8 months overall, 60.1 months for small bowel NETs (sbNETs), 39.1 months for pancreatic NETs (pNETs) and 67.7 months for lung NETs.

• #30 Delays and routes to diagnosis of neuroendocrine tumours | BMC Cancer | Full Text

  https://bmccancer.biomedcentral.com/articles/10.1186/s12885-018-5057-3

  80% of respondents reported that they had symptoms prior to diagnosis (243/303). Most of these respondents reported that their symptoms led to the NET diagnosis (73%, 221/303), in particular those with pNETs (73%, 47/64) and small bowel NETs (83%, 82/99). […] The time from first symptom to diagnosis was 53.8 months, which is a very long time especially when considering the number of respondents that regarded their primary symptom as being severe or very severe in nature. A significant delay is likely to be occurring due to incorrect initial diagnosis. […] The survey has clearly demonstrated that the majority of respondents with NETs do not present with typical symptoms. […] In summary, this survey demonstrates a mean time of 53.8 months from onset of symptoms to diagnosis. The primary symptoms from respondents appear linked to the primary site of the tumour and associated weight loss is a common finding. Respondents are seeking healthcare but are often misdiagnosed with functional gastrointestinal disorders.

• #31 What are the symptoms of neuroendocrine tumours (NETs)?

  https://www.livingwithnets.com/about-neuroendocrine-tumours-nets/learn-about-nets/symptoms-of-neuroendocrine-tumours-nets/

  NETs produce symptoms that are common to many other diseases. These symptoms include diarrhoea, flushing of the skin (particularly the face), wheezing, stomach pain, loss of appetite and bloating. Some people have no symptoms at all. […] Because NETs symptoms mimic other conditions, they are often misdiagnosed as another condition such as irritable bowel syndrome (IBS), Crohn’s disease, peptic ulcer disease, gastritis, asthma, blood glucose problems, the menopause or blood pressure problems. […] In some cases, NETs are found accidentally at an early disease stage during regular health checks, or during investigations or surgery for other conditions. An early diagnosis may help to improve the course of some NETs.

• #32 18 Facts You May Or May Not Know About NET Cancer

  https://netcancerawareness.org/cancer-facts/

  Over 90% of All Neuroendocrine Tumor (NET) Patients are Incorrectly Diagnosed and Treated for the Wrong Disease. […] Average Time From Initial Onset of Symptoms to Proper Diagnosis Exceeds Five Years. […] Most Prevalent Carcinoid/NET Symptoms are Diarrhea, Constipation, Abdominal Pain, Wheezing, Flushing, Heart Palpitations, and Blood Pressure Fluctuations. […] Some Types of NETs Do Not Cause Symptoms, While Others Cause General Gastrointestinal and Respiratory Symptoms That Mimic More Common Diseases. […] Some Pancreatic Neuroendocrine Tumors Cause Symptoms Because of the Different Hormones They Make and Release. […] Other Types of Pancreatic NETs Do Not Make and Release Hormones, But May Cause Symptoms When They Grow and Spread. […] Some Types of Lung NETs Can Cause Symptoms That Make Them Seem Like Other Respiratory Diseases. However, Some Patients May Not Have Symptoms at the Time They are Diagnosed. […] Neuroendocrine Carcinoma (NEC) is a More Aggressive Form of NETs and are a Greater Challenge to Treat.

• #33 How are neuroendocrine tumors diagnosed? | Roswell Park Comprehensive Cancer Center – Buffalo, NY

  https://www.roswellpark.org/cancertalk/202411/how-are-neuroendocrine-tumors-diagnosed

  Because NETs are perceived to be uncommon and may be nonspecific in their presentation, delays in diagnosis and misdiagnosis are frequent. […] Some of the common symptoms include: Diarrhea (including at night), Flushing (redness of the neck and face), Abdominal pain or cramping, High blood pressure, Fatigue, Headache, Nausea and/or vomiting, Pain from growing tumor, Weight loss. […] Due to the lack of a screening test to detect NETs, it is very important to tell your doctor about the specific symptoms that you are experiencing. […] The key to accurate diagnosis of NETs is having a complete picture of the patients symptoms, Dr. Iyer says. […] If your doctor suspects a NET, further evaluation including blood tests, urine tests, imaging tests and biopsy can be performed to confirm the diagnosis.

• #34 Neuroendocrine cancers | Cancer Research UK

  https://www.cancerresearchuk.org/about-cancer/neuroendocrine-tumours-nets

  Carcinoid syndrome is a group of symptoms including flushing of the skin and diarrhoea. It is caused by some NETs that produce large amounts of hormones. […] Survival (prognosis) depends on several factors. This includes your type of neuroendocrine cancer, where it is in your body, and whether it has spread.

• #35 Neuroendocrine cancers | Cancer Research UK

  https://www.nhs.uk/conditions/neuroendocrine-tumours/

  Carcinoid syndrome is a group of symptoms including flushing of the skin and diarrhoea. It is caused by some NETs that produce large amounts of hormones. […] Survival (prognosis) depends on several factors. This includes your type of neuroendocrine cancer, where it is in your body, and whether it has spread. […] Treatment depends on the type of neuroendocrine cancer you have, where it is, its size and whether it has spread (the stage).

• #36 Neuroendocrine Tumors (NETs) | Knight Cancer Institute | OHSU

  https://www.ohsu.edu/knight-cancer-institute/neuroendocrine-tumors-nets

  Neuroendocrine tumors (NETs) are a rare but complex type of cancer that can arise in many parts of the body. […] Most NETs grow slowly and don’t spread. But some grow faster and can spread to other parts of the body. […] About 95% of NETs develop in the digestive tract, the pancreas or in the lungs. They can be difficult to diagnose because they may cause no or few symptoms. […] NETs are often misdiagnosed at first. Some patients have no symptoms, while others have symptoms that mimic conditions like irritable bowel syndrome. Some NETs produce a surge of hormones, causing symptoms such as flushing, diarrhea, asthma-like wheezing, abdominal pain, fatigue, skin changes, nausea, weight loss, and unusual bleeding. […] The five-year relative survival rate for gastrointestinal NETs is 94%, according to the American Cancer Society. This rises to 97% if the NET is caught in the earliest stage. […] Patients can live with a NET for many years, which makes it vital to get expert treatment.

• #37 Gastrointestinal Neuroendocrine Tumors: Symptoms and Treatment

  https://my.clevelandclinic.org/health/diseases/24594-gastrointestinal-neuroendocrine-tumors

  Your prognosis, or expected outcome, may depend on when a tumor was diagnosed and treated. Approximately 97% of people with GI NET who received treatment before the tumor spread were alive five years after diagnosis. That five-year survival rate drops to 95% if the tumor spreads to nearby tissues or lymph nodes. Approximately 67% of people whose GI NET spread outside of their digestive tracts were alive five years after diagnosis. […] GI NET can come back. Depending on the tumor’s size, grade and location, you may have regular follow-up tests. For example, your provider may recommend you have annual CT scans for the first three years after treatment and annual physicals every year. Ask your healthcare provider about follow-up visits and tests for your specific situation.

• #38 Neuroendocrine Tumors (NETs): Symptoms & Treatment

  https://my.clevelandclinic.org/health/diseases/22006-neuroendocrine-tumors-net

  NETs are often mistaken for other less serious conditions, so it may take some time before you’re diagnosed. Once you learn you have a neuroendocrine tumor, your prognosis, or expected outcome, depends on several factors, including the type of NET you have and whether your tumor has spread. On average, an estimated 39% of people with NETs are alive five years after diagnosis. […] But one of the biggest challenges with this diagnosis is that although most NETs are slow-growing, they’ve often spread by the time they’re caught. At this point, treatment can help slow tumor growth and provide symptom relief. […] Neuroendocrine tumors and their treatment can take a toll on your body. You may have to manage common symptoms like fatigue feeling extremely tired day after day and diarrhea throughout your treatment.

• #39 Neuroendocrine Tumors: Symptoms & Treatment | Huntsman Cancer Institute | University of Utah Health

  https://healthcare.utah.edu/huntsmancancerinstitute/neuroendocrine-tumor/symptoms-treatment

  Fewer than half of people with a neuroendocrine tumor have symptoms. When symptoms occur, they can be vague and mimic other medical conditions, including different types of cancer. […] Symptoms vary with the types of hormones the neuroendocrine tumor secretes: Abdominal cramping, Bloating and gas, Blood pressure fluctuations, Diarrhea and nausea, Dizziness, Fatigue and muscle weakness, Flushed skin or rashes, Shortness of breath, Weight loss. […] Without treatment, NETs may spread elsewhere in your body, including your bones, liver, and lymph glands. […] Doctors cannot predict how long you will live with neuroendocrine tumor. However, many people live for decades. Early detection and aggressive monitoring are key to good outcomes. Evidence also suggests that patients who receive care from dedicated NET multidisciplinary teams have longer life expectancies than those treated with standard cancer care.

• #40 Neuroendocrine Tumors: Symptoms & Treatment | Huntsman Cancer Institute | University of Utah Health

  https://healthcare.utah.edu/huntsmancancerinstitute/neuroendocrine-tumor/symptoms-treatment

  Fewer than half of people with a neuroendocrine tumor have symptoms. When symptoms occur, they can be vague and mimic other medical conditions, including different types of cancer. […] Symptoms vary with the types of hormones the neuroendocrine tumor secretes: Abdominal cramping, Bloating and gas, Blood pressure fluctuations, Diarrhea and nausea, Dizziness, Fatigue and muscle weakness, Flushed skin or rashes, Shortness of breath, Weight loss. […] Without treatment, NETs may spread elsewhere in your body, including your bones, liver, and lymph glands. […] Doctors cannot predict how long you will live with neuroendocrine tumor. However, many people live for decades. Early detection and aggressive monitoring are key to good outcomes. Evidence also suggests that patients who receive care from dedicated NET multidisciplinary teams have longer life expectancies than those treated with standard cancer care.

• #41 Neuroendocrine Tumors (NETs) | Knight Cancer Institute | OHSU

  https://www.ohsu.edu/knight-cancer-institute/neuroendocrine-tumors-nets

  Neuroendocrine tumors (NETs) are a rare but complex type of cancer that can arise in many parts of the body. […] Most NETs grow slowly and don’t spread. But some grow faster and can spread to other parts of the body. […] About 95% of NETs develop in the digestive tract, the pancreas or in the lungs. They can be difficult to diagnose because they may cause no or few symptoms. […] NETs are often misdiagnosed at first. Some patients have no symptoms, while others have symptoms that mimic conditions like irritable bowel syndrome. Some NETs produce a surge of hormones, causing symptoms such as flushing, diarrhea, asthma-like wheezing, abdominal pain, fatigue, skin changes, nausea, weight loss, and unusual bleeding. […] The five-year relative survival rate for gastrointestinal NETs is 94%, according to the American Cancer Society. This rises to 97% if the NET is caught in the earliest stage. […] Patients can live with a NET for many years, which makes it vital to get expert treatment.

• #42 Neuroendocrine Cancer: Types, Causes, and Symptoms

  https://www.verywellhealth.com/neuroendocrine-cancer-6891989

  People with neuroendocrine lung tumors may cough, wheeze, develop pneumonia (a lung infection), or have chest pain. […] People with neuroendocrine cancer may also have more general cancer symptoms, including fatigue, loss of appetite, and unexplained weight loss. […] Your individual prognosis is based on many factors, including the size of the tumor, how much it has spread, what hormones it is making, where it is located, and if the cancer can be removed with surgery. […] Survival rates for neuroendocrine cancer vary by type of cancer and whether it has spread. These are averages and cannot predict the course of an individual’s cancer journey. Some neuroendocrine cancers are severe, mainly if they’ve already spread when discovered.

• #43 Neuroendocrine Tumors (NETs): Symptoms & Treatment

  https://my.clevelandclinic.org/health/diseases/22006-neuroendocrine-tumors-net

  NETs are often mistaken for other less serious conditions, so it may take some time before you’re diagnosed. Once you learn you have a neuroendocrine tumor, your prognosis, or expected outcome, depends on several factors, including the type of NET you have and whether your tumor has spread. On average, an estimated 39% of people with NETs are alive five years after diagnosis. […] But one of the biggest challenges with this diagnosis is that although most NETs are slow-growing, they’ve often spread by the time they’re caught. At this point, treatment can help slow tumor growth and provide symptom relief. […] Neuroendocrine tumors and their treatment can take a toll on your body. You may have to manage common symptoms like fatigue feeling extremely tired day after day and diarrhea throughout your treatment.

• #44 Symptom Management – NETRF

  https://netrf.org/old-for-patients/living-with-nets/symptom-management/

  A person with neuroendocrine tumors can have symptoms for a range of reasons. […] A neuroendocrine tumor may release hormones into the bloodstream […] Cancer treatment may have side effects […] Tumor size or site can lead to issues […] Associated syndromes may emerge […] Diabetes is connected to some pancreatic NETs […] Gallbladder problems are common […] Lactose intolerance sometimes develops. […] Tell your doctor about any symptoms or side effects. To convey the frequency and seriousness of any side effects, keep a log of your symptoms and share it with your care team. Your doctor may be able to recommend modifications or treatments to alleviate symptoms. […] Fatigue is one of the most common issues people living with NETs face. Their exhaustion can be beyond physical. It can include emotional exhaustion. And it is not an easy problem to tackle. But there are a few things you can do to help manage cancer-related fatigue. […] Talk to your care team about cancer-related fatigue. There may be tests or treatments that can help resolve the issue.

• #45 Patterns of Symptoms Burden in Neuroendocrine Tumors: A Population‐Based Analysis of Prospective Patient‐Reported Outcomes

  https://pmc.ncbi.nlm.nih.gov/articles/PMC6795154/

  Patients with NETs have a high prevalence of moderatetosevere patientreported symptoms, with little change over time. […] The proportion of moderatetosevere anxiety decreased by 10% within 6 months of diagnosis, followed by stability thereafter. […] The proportion of patients recording moderatetosevere symptoms over the 5 years following NET diagnosis is depicted in Figure 2. […] During this period, half the patients reported at least one moderatetosevere score for tiredness and overall wellbeing, and two out of five patients recorded at least one moderatetosevere score for anxiety. […] The highest burden of symptoms was observed in patients with bronchopulmonary NETs, followed by pancreatic and gastroenteric NETs. […] There was little change over time in the proportion of patients reporting moderatetosevere symptoms.

• #46 Patterns of Symptoms Burden in Neuroendocrine Tumors: A Population‐Based Analysis of Prospective Patient‐Reported Outcomes

  https://pmc.ncbi.nlm.nih.gov/articles/PMC6795154/

  Patients with NETs have a high prevalence of moderatetosevere patientreported symptoms, with little change over time. […] The proportion of moderatetosevere anxiety decreased by 10% within 6 months of diagnosis, followed by stability thereafter. […] The proportion of patients recording moderatetosevere symptoms over the 5 years following NET diagnosis is depicted in Figure 2. […] During this period, half the patients reported at least one moderatetosevere score for tiredness and overall wellbeing, and two out of five patients recorded at least one moderatetosevere score for anxiety. […] The highest burden of symptoms was observed in patients with bronchopulmonary NETs, followed by pancreatic and gastroenteric NETs. […] There was little change over time in the proportion of patients reporting moderatetosevere symptoms.

• #47 Patterns of Symptoms Burden in Neuroendocrine Tumors: A Population‐Based Analysis of Prospective Patient‐Reported Outcomes

  https://pmc.ncbi.nlm.nih.gov/articles/PMC6795154/

  The prevalence of moderatetosevere anxiety was higher at the time of diagnosis, dropped by 10% at 6 months, and was stable thereafter. […] Patients with gastroenteric NETs had a lower risk of reporting elevated scores compared with patients with bronchopulmonary NETs. […] Both synchronous and metachronous metastatic disease were independently associated with a higher risk of recording moderatetosevere scores. […] Older patients presented a lower risk of anxiety, nausea, and overall wellbeing. […] Lower SES (1st quintile) was associated with increased risk of anxiety, depression, drowsiness, pain, shortness of breath, and tiredness compared with the highest quintile. […] Patients remain at risk of prolonged symptom burden following diagnosis, highlighting potential unmet needs.

• #48 Patterns of Symptoms Burden in Neuroendocrine Tumors: A Population‐Based Analysis of Prospective Patient‐Reported Outcomes

  https://pmc.ncbi.nlm.nih.gov/articles/PMC6795154/

  The prevalence of moderatetosevere anxiety was higher at the time of diagnosis, dropped by 10% at 6 months, and was stable thereafter. […] Patients with gastroenteric NETs had a lower risk of reporting elevated scores compared with patients with bronchopulmonary NETs. […] Both synchronous and metachronous metastatic disease were independently associated with a higher risk of recording moderatetosevere scores. […] Older patients presented a lower risk of anxiety, nausea, and overall wellbeing. […] Lower SES (1st quintile) was associated with increased risk of anxiety, depression, drowsiness, pain, shortness of breath, and tiredness compared with the highest quintile. […] Patients remain at risk of prolonged symptom burden following diagnosis, highlighting potential unmet needs.

• #49 Patterns of Symptoms Burden in Neuroendocrine Tumors: A Population‐Based Analysis of Prospective Patient‐Reported Outcomes

  https://pmc.ncbi.nlm.nih.gov/articles/PMC6795154/

  The prevalence of moderatetosevere anxiety was higher at the time of diagnosis, dropped by 10% at 6 months, and was stable thereafter. […] Patients with gastroenteric NETs had a lower risk of reporting elevated scores compared with patients with bronchopulmonary NETs. […] Both synchronous and metachronous metastatic disease were independently associated with a higher risk of recording moderatetosevere scores. […] Older patients presented a lower risk of anxiety, nausea, and overall wellbeing. […] Lower SES (1st quintile) was associated with increased risk of anxiety, depression, drowsiness, pain, shortness of breath, and tiredness compared with the highest quintile. […] Patients remain at risk of prolonged symptom burden following diagnosis, highlighting potential unmet needs.

• #50 Symptom Management – NETRF

  https://netrf.org/old-for-patients/living-with-nets/symptom-management/

  A person with neuroendocrine tumors can have symptoms for a range of reasons. […] A neuroendocrine tumor may release hormones into the bloodstream […] Cancer treatment may have side effects […] Tumor size or site can lead to issues […] Associated syndromes may emerge […] Diabetes is connected to some pancreatic NETs […] Gallbladder problems are common […] Lactose intolerance sometimes develops. […] Tell your doctor about any symptoms or side effects. To convey the frequency and seriousness of any side effects, keep a log of your symptoms and share it with your care team. Your doctor may be able to recommend modifications or treatments to alleviate symptoms. […] Fatigue is one of the most common issues people living with NETs face. Their exhaustion can be beyond physical. It can include emotional exhaustion. And it is not an easy problem to tackle. But there are a few things you can do to help manage cancer-related fatigue. […] Talk to your care team about cancer-related fatigue. There may be tests or treatments that can help resolve the issue.

• #51 How are neuroendocrine tumors diagnosed? | Roswell Park Comprehensive Cancer Center – Buffalo, NY

  https://www.roswellpark.org/cancertalk/202411/how-are-neuroendocrine-tumors-diagnosed

  The diagnosis and treatment of a NET requires a coordinated multidisciplinary approach involving an expert team of specialists including medical oncologists, surgeons, interventional radiologists, pathologists, nutritionists, social workers and other healthcare staff, Dr. Iyer says. […] Results from pathology testing, hormonal testing, and diagnostic and functional imaging are integrated to form a complete diagnostic picture. […] Along with a team of dedicated NET experts, with nearly 20 years of experience in diagnosing and treating NET patients, Roswell Park is a leading center for NET care, committed to giving patient-centered care and holistic approaches to treatment. […] In addition to development of this bank, the team is very actively involved in NET research, including multiple clinical trials for NET patients.

• #52 Functioning and Non-functioning Neuroendocrine Tumours

  https://neuroendocrine.org.au/what-are-nets/functioning-and-non-functioning-neuroendocrine-tumours/

  In contrast, non-functioning NETs may present with more subtle symptoms related to the physical presence of the tumour. Depending on the size and location of the tumour, patients may experience symptoms such as: Abdominal pain, Bowel obstruction, Unexplained weight loss. The challenge with non-functioning NETs lies in their ability to remain asymptomatic until they reach a more advanced stage. Early intervention and diagnosis are critical steps in creating the best outlook for these patients. […] Patients with functioning NETs may experience relief from symptoms such as diarrhoea, flushing, and abdominal pain through targeted interventions. The goal is not only to manage symptoms but also to control hormone production and potentially shrink the tumour. For non-functioning NETs, the emphasis is often on alleviating symptoms related to the physical presence of the tumour, such as abdominal pain or bowel obstruction. Treatment aims to enhance quality of life by controlling the growth and spread of the tumour.

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