Astma zawodowa
Leczenie

Leczenie astmy zawodowej opiera się przede wszystkim na całkowitym unikaniu ekspozycji na czynnik wywołujący, zwłaszcza w przypadku astmy immunologicznej, gdzie nawet minimalne ilości alergenu mogą wywołać objawy. Farmakoterapia jest analogiczna do leczenia astmy niezawodowej i obejmuje stosowanie wziewnych kortykosteroidów, modyfikatorów leukotrienów, długo działających beta-agonistów (LABA) oraz leków doraźnych, takich jak krótko działające beta-agonisty (SABA). W ciężkich przypadkach stosuje się leki biologiczne (np. omalizumab, przeciwciała anty-IL5, anty-IL4/IL13) oraz metody takie jak termoplastyka oskrzeli czy immunoterapia alergenowa. Kluczowe jest wczesne rozpoznanie i szybkie usunięcie pacjenta z ekspozycji, co poprawia rokowanie i może prowadzić do całkowitego wyleczenia u około 30% chorych. Regularne monitorowanie czynności płuc, objawów i zużycia leków jest niezbędne, szczególnie u osób pozostających w środowisku pracy z potencjalnym ryzykiem ekspozycji.

Leczenie astmy zawodowej – podstawowe zasady

Leczenie astmy zawodowej opiera się na kilku podstawowych zasadach, przy czym najważniejszym elementem terapii jest unikanie ekspozycji na czynnik wywołujący objawy. Badania wykazują, że wczesne rozpoznanie choroby i jak najszybsze usunięcie pacjenta z narażenia na czynnik sprawczy po wystąpieniu pierwszych objawów znacząco zwiększa szanse na poprawę stanu zdrowia, a w niektórych przypadkach nawet na całkowite wyleczenie.1 Farmakoterapia astmy zawodowej jest zasadniczo taka sama jak w przypadku astmy niezwiązanej z pracą zawodową, jednak sama terapia lekami bez unikania czynnika wywołującego nie jest wystarczająca do zapobiegania pogorszeniu czynności płuc u pacjentów z astmą wywołaną czynnikami uczulającymi.23

Celem leczenia astmy zawodowej jest zapobieganie objawom i zatrzymanie napadu astmy w trakcie, gdy już wystąpi. Odpowiednie leczenie polega na połączeniu unikania dalszej ekspozycji na czynniki uczulające, zmniejszenia ekspozycji na czynniki drażniące oraz farmakoterapii dostosowanej do nasilenia astmy.45

Unikanie ekspozycji – kluczowy element leczenia

Unikanie ekspozycji na czynnik wywołujący jest najważniejszym aspektem leczenia astmy zawodowej, szczególnie tej wywołanej mechanizmami immunologicznymi. Gdy pacjent zostanie uczulony na dany czynnik, nawet minimalne ilości substancji mogą wyzwalać objawy astmy, nawet jeśli stosuje maskę lub respirator.67 Najskuteczniejszą interwencją po zidentyfikowaniu immunologicznej astmy zawodowej jest szybkie usunięcie pracownika z dalszej ekspozycji na czynnik uczulający.

U pacjentów z astmą zawodową, którzy pozostają w środowisku pracy, obserwuje się zazwyczaj postępujące pogarszanie czynności płuc, a w skrajnych przypadkach opisywano nawet przypadki śmiertelne wśród pracowników narażonych na ciągłą ekspozycję na antygeny o wysokiej lub niskiej masie cząsteczkowej.89

Strategie unikania ekspozycji

Dostępnych jest kilka strategii unikania lub ograniczania ekspozycji zawodowej:10

  • Całkowite usunięcie czynnika uczulającego ze środowiska pracy
  • Zastąpienie czynnika wywołującego bezpieczną alternatywą
  • Zmiana miejsca pracy lub stanowiska w obrębie tego samego zakładu
  • Poprawa wentylacji i wprowadzenie środków kontroli technicznej
  • Stosowanie środków ochrony indywidualnej (choć jest to najniższy poziom w hierarchii kontroli narażenia zawodowego)
  • Programy edukacyjne mające na celu zapobieganie lub zmniejszanie ekspozycji

1112

Ważne jest, aby zauważyć, że samo ograniczenie ekspozycji (bez całkowitego jej wyeliminowania) może być niewystarczające w przypadku osób z astmą immunologiczną, gdyż nawet minimalna ekspozycja może wywołać reakcję alergiczną.13 Z kolei pacjenci z astmą wywołaną przez czynniki drażniące lub astmą zaostrzaną przez pracę mogą często kontynuować pracę na dotychczasowym stanowisku, jeśli zostaną wdrożone odpowiednie środki zmniejszające ekspozycję na czynniki wyzwalające.14

Skuteczność interwencji w miejscu pracy

Przegląd systematyczny Cochrane dotyczący interwencji w miejscu pracy w leczeniu astmy zawodowej wykazał, że:1516

  • Zarówno usunięcie z ekspozycji, jak i jej ograniczenie mogą poprawić objawy astmy w porównaniu z kontynuacją ekspozycji
  • Usunięcie z ekspozycji, ale nie jej ograniczenie, może poprawić czynność płuc w porównaniu z kontynuacją ekspozycji
  • Usunięcie z ekspozycji może skuteczniej poprawiać objawy i czynność płuc niż ograniczenie ekspozycji, zwłaszcza u pacjentów narażonych na czynniki o niskiej masie cząsteczkowej
  • Usunięcie z ekspozycji może jednak zwiększać ryzyko bezrobocia

1718

Lekarze powinni zatem równoważyć potencjalne korzyści kliniczne usunięcia z ekspozycji lub jej ograniczenia z potencjalnymi szkodliwymi skutkami bezrobocia.19

Farmakoterapia astmy zawodowej

Farmakoterapia astmy zawodowej jest podobna do leczenia innych rodzajów astmy i obejmuje stosowanie leków kontrolujących i leków doraźnych. Odpowiednie leki dla danego pacjenta zależą od wielu czynników, w tym wieku, objawów, czynników wyzwalających astmę oraz skuteczności danego leku w kontrolowaniu astmy u konkretnego pacjenta.20

Leki kontrolujące (długoterminowe)

Leki kontrolujące stosowane są codziennie w celu zapobiegania i kontrolowania objawów astmy poprzez zmniejszanie stanu zapalnego dróg oddechowych.21 Do głównych grup leków kontrolujących należą:

  • Wziewne kortykosteroidy – podstawowe leki przeciwzapalne, zmniejszające stan zapalny w drogach oddechowych
  • Modyfikatory leukotrienów – alternatywa dla kortykosteroidów, zwłaszcza w łagodniejszych postaciach astmy
  • Długo działające beta-agoniści (LABA) – rozszerzają oskrzela i zmniejszają stan zapalny; powinny być stosowane wyłącznie w połączeniu z wziewnymi kortykosteroidami
  • Inhalatory złożone – zawierają LABA i kortykosteroid
  • Teofilina – lek rozszerzający oskrzela stosowany rzadziej niż w przeszłości

222324

Leki doraźne

Leki doraźne (ratunkowe) stosowane są w przypadku wystąpienia objawów astmy lub napadu astmy. Służą do szybkiego opanowania objawów poprzez rozszerzenie oskrzeli.25 Obejmują one:

  • Krótko działające beta-agoniści (SABA) – jak salbutamol (albuterol) lub terbutalina, szybko rozszerzające oskrzela
  • Doustne i dożylne kortykosteroidy – stosowane w ciężkich zaostrzeniach astmy
  • Leki przeciwcholinergiczne – jak ipratropium, mogą być stosowane jako dodatkowe leki rozszerzające oskrzela

2627

Jeśli pacjent musi używać inhalatora doraźnego częściej niż zalecane, może to oznaczać konieczność dostosowania leku kontrolującego długoterminowo.28

Terapie biologiczne

W przypadku ciężkiej astmy zawodowej, która nie odpowiada na standardowe leczenie, mogą być stosowane leki biologiczne, takie jak:2930

  • Przeciwciała anty-IgE (omalizumab)
  • Przeciwciała anty-IL5
  • Przeciwciała anty-IL4/IL13

Leki biologiczne ukierunkowane są na konkretne komórki, szlaki i białka odpowiedzialne za stan zapalny w organizmie. Skupiają się na leczeniu źródła objawów, a nie samych objawów.31

Inne metody leczenia

W przypadku ciężkiej, trudnej do kontrolowania astmy, mogą być rozważane dodatkowe metody leczenia, takie jak:32

  • Termoplastyka oskrzeli – zabieg ambulatoryjny polegający na dostarczaniu kontrolowanej energii cieplnej do ściany dróg oddechowych podczas serii procedur bronchoskopowych. Jest przeznaczona dla dorosłych w wieku powyżej 18 lat z ciężką astmą, której objawy utrzymują się pomimo standardowej terapii.
  • Immunoterapia alergenowa – może być rozważana, jeśli konkretne alergeny mają udowodniony związek z objawami, dostępna jest szczepionka na alergen, osoba jest uczulona (np. dodatni wynik testu skórnego lub RAST), alergen nie może być uniknięty i jest obecny przez cały rok, a objawy są słabo kontrolowane farmakoterapią.3334

Kompleksowe podejście do leczenia astmy zawodowej

Optymalne leczenie astmy zawodowej wymaga kompleksowego podejścia obejmującego nie tylko farmakoterapię i unikanie czynników wyzwalających, ale również edukację pacjenta, regularne monitorowanie czynności płuc oraz współpracę z pracodawcą.35

Edukacja i monitorowanie

Kluczowe elementy kompleksowego leczenia astmy zawodowej obejmują:3637

  • Edukację pacjenta na temat diagnozy, implikacji dla obecnej i przyszłej pracy oraz możliwości odszkodowania
  • Opracowanie spersonalizowanego planu działania w przypadku astmy
  • Regularne monitorowanie kontroli astmy, czynności płuc i wpływu interwencji w miejscu pracy
  • Poradnictwo w zakresie rzucania palenia
  • Ocenę i leczenie współistniejących schorzeń (np. alergicznego nieżytu nosa, zaburzeń oddychania, indukowanej niedrożności krtani, lęku i depresji)

U pacjentów z astmą zawodową konieczne jest regularne monitorowanie obejmujące ocenę objawów, zużycia leków i czynności płuc.38 Szczególnie ważne jest to w przypadkach, gdy istnieje potencjalne ryzyko dalszej ekspozycji na czynnik uczulający.

Współpraca z pracodawcą

Leczenie astmy zawodowej często wymaga współpracy z pracodawcą w celu zminimalizowania ekspozycji na czynniki wyzwalające w miejscu pracy. W ramach tej współpracy mogą być podejmowane następujące działania:3940

  • Zastąpienie substancji, która spowodowała astmę zawodową, bezpieczną alternatywą
  • Przeniesienie pracownika na stanowisko, gdzie nie będzie narażony na szkodliwą substancję
  • Wdrożenie środków kontroli technicznej (np. poprawa wentylacji)
  • Zapewnienie odpowiednich środków ochrony indywidualnej
  • Programy edukacyjne zaprojektowane w celu zapobiegania lub zmniejszenia ekspozycji

Zgodnie z przepisami dotyczącymi bezpieczeństwa i higieny pracy, pracodawca jest zobowiązany do informowania pracowników o zagrożeniach związanych z ich pracą oraz zapewnienia bezpiecznego i zdrowego miejsca pracy.4142

Różnice w leczeniu różnych typów astmy zawodowej

Podejście terapeutyczne może się różnić w zależności od typu astmy zawodowej:4344

Astma wywołana czynnikami uczulającymi

W przypadku astmy wywoływanej przez czynniki uczulające, po uczuleniu pacjenci mogą reagować na niezwykle niskie poziomy ekspozycji. Zalecane postępowanie obejmuje identyfikację i całkowite usunięcie z dalszej ekspozycji na czynnik uczulający. Ze względu na to, że całkowite usunięcie z miejsca pracy może wiązać się z istotnymi konsekwencjami społeczno-ekonomicznymi, czasem próbuje się przeniesienia na inne stanowisko pracy w tym samym zakładzie lub poprawy kontroli technicznej.45

W sytuacjach z potencjalną ciągłą ekspozycją na czynnik uczulający, niezbędne jest ścisłe monitorowanie nasilenia astmy, w tym objawów, zużycia leków i czynności płuc. Wczesne rozpoznanie i szybkie usunięcie z ekspozycji na czynnik uczulający daje lepsze wyniki, ale astma często utrzymuje się nawet po usunięciu z ekspozycji.46

Astma wywołana czynnikami drażniącymi

W przypadku astmy wywołanej przez czynniki drażniące i astmy zaostrzanej przez pracę, istnieje nadzieja, że pracownicy mogą kontynuować swoją obecną pracę, jeśli wdrożone zostaną odpowiednie środki mające na celu zmniejszenie ekspozycji na czynniki wyzwalające. Obejmują one lepszą kontrolę techniczną ekspozycji na czynniki drażniące oraz dostosowania pozwalające na unikanie określonych zadań lub lokalizacji, takich jak praca w gorącym lub zimnym pomieszczeniu.47

Ważne jest regularne monitorowanie objawów astmy i jej kontroli. Jeśli astma pacjenta pogarsza się w pracy, konieczne mogą być dalsze modyfikacje pracy, w tym zmiana zatrudnienia.48

Rokowanie i długoterminowe skutki

Rokowanie w astmie zawodowej zależy od kilku czynników, w tym czasu trwania ekspozycji, czasu od wystąpienia objawów do diagnozy i interwencji, oraz typu astmy zawodowej.49

Długotrwała ekspozycja na czynnik wywołujący wiąże się z gorszym rokowaniem. Chociaż astma utrzymuje się u większości osób nawet po usunięciu z ekspozycji, w niektórych przypadkach astma zawodowa może być wyleczona, jeśli usunięcie z ekspozycji nastąpi wcześnie po wystąpieniu objawów.50

Zarówno astma wywołana przez czynniki uczulające, jak i drażniące często utrzymuje się nawet po usunięciu pacjentów z ekspozycji na czynnik przyczynowy, co może wymagać długoterminowego stosowania leków przeciwastmatycznych.51

Według danych statystycznych, około 3 na 10 osób z astmą zawodową, które przestają być narażone na szkodliwą substancję, całkowicie wraca do zdrowia.52 Jednak jeśli astma zawodowa nie zostanie odpowiednio wcześnie zdiagnozowana i leczona, może prowadzić do trwałego uszkodzenia płuc.53

Podsumowanie wytycznych leczenia

Najważniejsze elementy w leczeniu astmy zawodowej obejmują:54

  • Rozważenie astmy zawodowej u wszystkich dorosłych z nowo rozpoznaną lub zaostrzającą się astmą
  • Minimalizowanie ekspozycji na czynniki wyzwalające i drażniące w miejscu pracy i w domu
  • Farmakoterapię astmy zawodowej podobną do leczenia innych rodzajów astmy
  • Wczesne skierowanie pacjentów z podejrzeniem astmy zawodowej do specjalistycznej oceny, najlepiej w ośrodku chorób zawodowych płuc lub ośrodku leczenia astmy
  • Regularne monitorowanie objawów, zużycia leków i czynności płuc u pacjentów z ryzykiem ciągłej ekspozycji na czynnik wywołujący

5556

U pacjentów z astmą zawodową wywołaną przez czynniki uczulające zaleca się całkowite unikanie dalszej ekspozycji na ten czynnik. W przypadku astmy wywołanej przez czynniki drażniące i astmy zaostrzanej przez pracę, pacjenci mogą często kontynuować swoją obecną pracę przy odpowiednich środkach kontroli ekspozycji i farmakoterapii.5758

Optymalne leczenie astmy zawodowej wymaga współpracy między pacjentem, lekarzem i pracodawcą w celu zminimalizowania ekspozycji na czynniki wyzwalające, zapewnienia odpowiedniej kontroli astmy i monitorowania skutków interwencji.59

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  1. 10.04.2026
  2. www.leksykon.com.pl

Materiały źródłowe

  • #1 Occupational asthma: Management, prognosis, and prevention – UpToDate
    https://www.uptodate.com/contents/occupational-asthma-management-prognosis-and-prevention
    Occupational asthma (OA) is a form of work-related asthma that is characterized by variable airflow limitation, airway hyperresponsiveness, and airway inflammation induced by immunologic or nonimmunologic exposures in the work environment. The management, prognosis, and prevention of OA will be reviewed here. […] The key element is to make the diagnosis and remove the subject from exposure as quickly as possible after the onset of symptoms, as a long duration of exposure is associated with a poor prognosis of the disease. Although asthma is persistent in the majority of subjects even after removal from exposure, OA may be cured in some cases if removal from exposure occurs early following onset of symptoms. The management of OA requires a combination of avoidance of further exposure to sensitizing agents, reduction in exposure to irritant agents (eg, environmental tobacco smoke, strong fumes and fragrances, extremes of temperature and humidity) and pharmacotherapy based on the severity of asthma.
  • #2 Occupational Asthma
    https://www.clevelandclinicmeded.com/medicalpubs/diseasemanagement/allergy/occupational-asthma/
    The most important aspect in the treatment of OA is environmental control. Continued exposure can lead to persistent and irreversible airway obstruction, whereas early removal offers the best chance at complete recovery. Other than environmental control, the management of OA is no different than that for non-OA. However, pharmacologic treatment is not effective in preventing deterioration of lung function in sensitizer-induced OA when subjects remain exposed to the causal agent. […] In contrast, patients with RADS or IrIA without concurrent sensitization can usually return to the workplace if they have adequate pharmacologic control of their asthma and if there are appropriate occupational hygiene controls in place to prevent the likelihood of a repeat high-level respiratory irritant exposure.
  • #3 Work-Related Asthma | AAFP
    https://www.aafp.org/pubs/afp/issues/2001/1201/p1839.html
    Treatment for occupational asthma use of anti-inflammatory medications such as inhaled steroids and bronchodilators is the same as that for nonoccupational asthma. […] Medical treatment for all types of work-related asthma is similar to the standard treatment for asthma. The primary underlying pathophysiologic process in all forms of asthma is airway inflammation, and the first line of treatment should be anti-inflammatory medication. In most patients with asthma, inhaled steroids are the medication of choice, with adjunctive use of bronchodilators to relieve acute bronchospasmodic symptoms. […] Employees with allergic occupational asthma should be removed from exposure to the causative agent. For these sensitized persons, reduction of exposure levels alone is inadequate because any exposure, even in minute concentrations, can trigger an allergic reaction. Adequate treatment of asthma symptoms does not replace the need for avoiding the offending agent. Continued exposure of persons with allergic occupational asthma is associated with significant morbidity and, occasionally, mortality.
  • #4 Occupational asthma – Diagnosis and treatment – Mayo Clinic
    https://www.mayoclinic.org/diseases-conditions/occupational-asthma/diagnosis-treatment/drc-20375777
    The goal of treatment is to prevent symptoms and stop an asthma attack in progress. […] Avoiding the workplace substance that causes your symptoms is important. Once you become sensitive to a substance, tiny amounts may trigger asthma symptoms, even if you wear a mask or respirator. […] You may need medicines for successful treatment. The same medicines are used to treat both occupational and nonoccupational asthma. […] The right medicine for you depends on many things. These include your age, symptoms, asthma triggers and what seems to work best to keep your asthma under control. […] Long-term control medicines include inhaled corticosteroids, leukotriene modifiers, long-acting beta agonists (LABAs), and combination inhalers. […] Quick-relief, short-term medications include short-acting beta agonists and oral and intravenous corticosteroids.
  • #5 Occupational asthma: Management, prognosis, and prevention – UpToDate
    https://www.uptodate.com/contents/occupational-asthma-management-prognosis-and-prevention
    Occupational asthma (OA) is a form of work-related asthma that is characterized by variable airflow limitation, airway hyperresponsiveness, and airway inflammation induced by immunologic or nonimmunologic exposures in the work environment. The management, prognosis, and prevention of OA will be reviewed here. […] The key element is to make the diagnosis and remove the subject from exposure as quickly as possible after the onset of symptoms, as a long duration of exposure is associated with a poor prognosis of the disease. Although asthma is persistent in the majority of subjects even after removal from exposure, OA may be cured in some cases if removal from exposure occurs early following onset of symptoms. The management of OA requires a combination of avoidance of further exposure to sensitizing agents, reduction in exposure to irritant agents (eg, environmental tobacco smoke, strong fumes and fragrances, extremes of temperature and humidity) and pharmacotherapy based on the severity of asthma.
  • #6 Occupational asthma – Diagnosis and treatment – Mayo Clinic
    https://www.mayoclinic.org/diseases-conditions/occupational-asthma/diagnosis-treatment/drc-20375777
    The goal of treatment is to prevent symptoms and stop an asthma attack in progress. […] Avoiding the workplace substance that causes your symptoms is important. Once you become sensitive to a substance, tiny amounts may trigger asthma symptoms, even if you wear a mask or respirator. […] You may need medicines for successful treatment. The same medicines are used to treat both occupational and nonoccupational asthma. […] The right medicine for you depends on many things. These include your age, symptoms, asthma triggers and what seems to work best to keep your asthma under control. […] Long-term control medicines include inhaled corticosteroids, leukotriene modifiers, long-acting beta agonists (LABAs), and combination inhalers. […] Quick-relief, short-term medications include short-acting beta agonists and oral and intravenous corticosteroids.
  • #7 Occupational asthma: Management, prognosis, and prevention – UpToDate
    https://www.uptodate.com/contents/occupational-asthma-management-prognosis-and-prevention
    Exposure avoidance is the cornerstone of management of immunologic OA. The most important intervention after identification of immunologic OA is prompt removal of the worker from further exposure to the sensitizing agent. Patients with OA generally have progressive deterioration in lung function if they remain in the working environment, and fatal cases have occurred among workers with ongoing workplace exposure to either high-molecular-weight or low-molecular-weight provocative antigens.
  • #8 Occupational asthma: Management, prognosis, and prevention – UpToDate
    https://www.uptodate.com/contents/occupational-asthma-management-prognosis-and-prevention
    Exposure avoidance is the cornerstone of management of immunologic OA. The most important intervention after identification of immunologic OA is prompt removal of the worker from further exposure to the sensitizing agent. Patients with OA generally have progressive deterioration in lung function if they remain in the working environment, and fatal cases have occurred among workers with ongoing workplace exposure to either high-molecular-weight or low-molecular-weight provocative antigens.
  • #9 Work-Related Asthma | AAFP
    https://www.aafp.org/pubs/afp/issues/2001/1201/p1839.html
    Treatment for occupational asthma use of anti-inflammatory medications such as inhaled steroids and bronchodilators is the same as that for nonoccupational asthma. […] Medical treatment for all types of work-related asthma is similar to the standard treatment for asthma. The primary underlying pathophysiologic process in all forms of asthma is airway inflammation, and the first line of treatment should be anti-inflammatory medication. In most patients with asthma, inhaled steroids are the medication of choice, with adjunctive use of bronchodilators to relieve acute bronchospasmodic symptoms. […] Employees with allergic occupational asthma should be removed from exposure to the causative agent. For these sensitized persons, reduction of exposure levels alone is inadequate because any exposure, even in minute concentrations, can trigger an allergic reaction. Adequate treatment of asthma symptoms does not replace the need for avoiding the offending agent. Continued exposure of persons with allergic occupational asthma is associated with significant morbidity and, occasionally, mortality.
  • #10 Workplace interventions for treatment of occupational asthma – TBV-Online
    https://www.tbv-online.nl/magazine-artikelen/workplace-interventions-for-treatment-of-occupational-asthma/
    Workplace interventions for treatment of occupational asthma […] Workplace interventions to improve the status of workers who have occupational asthma either include early removal from exposure or reduction of exposure. Removal from exposure includes substitution of causal agents or complete removal from exposure. Reduction of exposure includes changing the work process; relocation of the affected worker to another work area with less exposure; implementation of educational programs designed to prevent or reduce exposure, and adaptions in personal protective equipment. However, the actual benefits of these interventions are still unclear. […] The Cochrane review by Henneberger et al (2019) is based on 26 non-randomized controlled before and after studies including 1,695 participants with occupational asthma. Sensitizers caused nearly all cases. The review focuses on the interventions of removal from exposure and reduction of exposure, which were compared with continued exposure.
  • #11 Workplace interventions for treatment of occupational asthma – TBV-Online
    https://www.tbv-online.nl/magazine-artikelen/workplace-interventions-for-treatment-of-occupational-asthma/
    Workplace interventions for treatment of occupational asthma […] Workplace interventions to improve the status of workers who have occupational asthma either include early removal from exposure or reduction of exposure. Removal from exposure includes substitution of causal agents or complete removal from exposure. Reduction of exposure includes changing the work process; relocation of the affected worker to another work area with less exposure; implementation of educational programs designed to prevent or reduce exposure, and adaptions in personal protective equipment. However, the actual benefits of these interventions are still unclear. […] The Cochrane review by Henneberger et al (2019) is based on 26 non-randomized controlled before and after studies including 1,695 participants with occupational asthma. Sensitizers caused nearly all cases. The review focuses on the interventions of removal from exposure and reduction of exposure, which were compared with continued exposure.
  • #12 Workplace interventions for treatment of occupational asthma – Henneberger, PK – 2019 | Cochrane Library
    https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD006308.pub4/full
    The most commonly recommended workplace interventions for managing occupational asthma are removal from exposure or reduction of exposure to the causal agents, in contrast to allowing the patient to work in circumstances with continued exposure. Cessation of exposure can be accomplished by eliminating the agent from the work environment with or without substituting another product. […] Reduction of exposure can be achieved by introducing or improving engineering controls like local exhaust ventilation or with respiratory personal protective equipment (PPE). Also, the worker with occupational asthma can potentially move to another job with less exposure, either with the same employer as their old job or with another employer entirely. […] The purpose of workplace interventions for treating occupational asthma is to prevent or significantly reduce the inhalation of airborne substances that are harmful for people who suffer from asthma. This is achieved in workplaces by either completely removing the symptomatic worker from the workplace where the exposure occurs or by reducing the exposure (i.e., the cause of asthma) by limiting use of the causal agent or improving ventilation and use of protective equipment in the same job, changing to another job with intermittent exposure, and education programs.
  • #13 Work-Related Asthma | AAFP
    https://www.aafp.org/pubs/afp/issues/2001/1201/p1839.html
    Treatment for occupational asthma use of anti-inflammatory medications such as inhaled steroids and bronchodilators is the same as that for nonoccupational asthma. […] Medical treatment for all types of work-related asthma is similar to the standard treatment for asthma. The primary underlying pathophysiologic process in all forms of asthma is airway inflammation, and the first line of treatment should be anti-inflammatory medication. In most patients with asthma, inhaled steroids are the medication of choice, with adjunctive use of bronchodilators to relieve acute bronchospasmodic symptoms. […] Employees with allergic occupational asthma should be removed from exposure to the causative agent. For these sensitized persons, reduction of exposure levels alone is inadequate because any exposure, even in minute concentrations, can trigger an allergic reaction. Adequate treatment of asthma symptoms does not replace the need for avoiding the offending agent. Continued exposure of persons with allergic occupational asthma is associated with significant morbidity and, occasionally, mortality.
  • #14 Work-Related Asthma – Pulmonary Disorders – Merck Manual Professional Edition
    https://www.merckmanuals.com/professional/pulmonary-disorders/environmental-and-occupational-pulmonary-diseases/work-related-asthma
    For patients with irritant-induced occupational asthma and work-exacerbated asthma, the hope is that workers can continue their current jobs if adequate measures are implemented to reduce triggering exposures and conditions. These include better engineering controls of irritant exposures and accommodations to avoid certain job tasks or locations, such as work in a hot or cold room. Regular monitoring of asthma symptoms and control is important. If the patients asthma worsens at work, further work modifications, including change in employment, may be necessary. Standard asthma treatment, including pharmacologic treatment and minimizing home and environmental triggers, is recommended. […] Both sensitizer-induced and irritant-induced asthma commonly persists even when patients are away from the causative exposure, and patients may require long-term use of asthma medications. Clinicians should document the diagnosis of work-related asthma and specific causative factors before making recommendations about work.
  • #15 Workplace interventions for treatment of occupational asthma – Henneberger, PK – 2019 | Cochrane Library
    https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD006308.pub4/full
    Workplace interventions for treatment of occupational asthma […] The impact of workplace interventions on the outcome of occupational asthma is not well understood. […] To evaluate the effectiveness of workplace interventions on occupational asthma. […] We included all eligible randomized controlled trials, controlled before and after studies and interrupted timeseries of workplace interventions for occupational asthma. […] Both removal from exposure and reduction of exposure may improve asthma symptoms compared with continued exposure. Removal from exposure, but not reduction of exposure, may improve lung function compared to continued exposure. When we compared removal from exposure directly to reduction of exposure, the former may improve symptoms and lung function more among patients exposed to low molecular weight agents. Removal from exposure may also increase the risk of unemployment. Care providers should balance the potential clinical benefits of removal from exposure or reduction of exposure with potential detrimental effects of unemployment. Additional highquality studies are needed to evaluate the effectiveness of workplace interventions for occupational asthma.
  • #16 Workplace interventions for treatment of occupational asthma – Henneberger, PK – 2019 | Cochrane Library
    https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD006308.pub4/full
    The review is based on 26 studies that included 1,695 participants with occupational asthma. Sensitizers caused nearly all cases. We focused on the interventions of removal from exposure and reduction of exposure, which were compared with continued exposure. Outcomes were changes in asthma symptoms, lung function, and nonspecific bronchial hyperreactivity between baseline and followup. […] Both removal from exposure and reduction of exposure may improve asthma symptoms when compared to continued exposure. Removal from exposure, but not reduction of exposure, may improve lung function when compared to continued exposure. Removal from exposure may improve symptoms and lung function more than reduction of exposure among patients exposed to low molecular weight agents, but removal may also increase the risk of unemployment. Consequently, the benefit of a better improvement has to be weighed against the potential for a higher risk of job loss.
  • #17 Workplace interventions for treatment of occupational asthma – Henneberger, PK – 2019 | Cochrane Library
    https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD006308.pub4/full
    Workplace interventions for treatment of occupational asthma […] The impact of workplace interventions on the outcome of occupational asthma is not well understood. […] To evaluate the effectiveness of workplace interventions on occupational asthma. […] We included all eligible randomized controlled trials, controlled before and after studies and interrupted timeseries of workplace interventions for occupational asthma. […] Both removal from exposure and reduction of exposure may improve asthma symptoms compared with continued exposure. Removal from exposure, but not reduction of exposure, may improve lung function compared to continued exposure. When we compared removal from exposure directly to reduction of exposure, the former may improve symptoms and lung function more among patients exposed to low molecular weight agents. Removal from exposure may also increase the risk of unemployment. Care providers should balance the potential clinical benefits of removal from exposure or reduction of exposure with potential detrimental effects of unemployment. Additional highquality studies are needed to evaluate the effectiveness of workplace interventions for occupational asthma.
  • #18 Workplace interventions to deal with occupational asthma | Cochrane
    https://www.cochrane.org/CD006308/OCCHEALTH_workplace-interventions-deal-occupational-asthma
    Clinicians and researchers have proposed several changes in workplaces to improve the status of workers who have occupational asthma, which is asthma whose onset is caused by occupational exposures. […] To determine the effectiveness of workplace interventions for the treatment of occupational asthma. […] We conducted a systematic review of workplace interventions for treating occupational asthma. Asthma symptoms and lung function may improve when persons with occupational asthma are removed from exposure, usually by ending their job, compared to continued exposure on the same job. […] Both removal from exposure and reduction of exposure may improve asthma symptoms when compared to continued exposure. Removal from exposure, but not reduction of exposure, may improve lung function when compared to continued exposure.
  • #19 Workplace interventions for treatment of occupational asthma – Henneberger, PK – 2019 | Cochrane Library
    https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD006308.pub4/full
    Our review indicates that removing individuals with occupational asthma from exposure may be associated with several beneficial health outcomes (i.e., for asthma symptoms, FEV1 %, and NSBH) in comparison to continuing exposure. We are unsure because of the very low quality of the evidence. Reduction of exposure may also be associated with beneficial effects in symptoms relative to continued exposure, but not for FEV1 %. Removal of exposure may be associated with better results for asthma symptoms and FEV1 % in comparison to reduction of exposure for cases attributed to LMW agents. Reduction of exposure may be associated with less unemployment than removal from exposure. Providers should balance the potential clinical benefits of removal from exposure versus reduction of exposure with potential detrimental effects of unemployment.
  • #20 Occupational asthma – Diagnosis and treatment – Mayo Clinic
    https://www.mayoclinic.org/diseases-conditions/occupational-asthma/diagnosis-treatment/drc-20375777
    The goal of treatment is to prevent symptoms and stop an asthma attack in progress. […] Avoiding the workplace substance that causes your symptoms is important. Once you become sensitive to a substance, tiny amounts may trigger asthma symptoms, even if you wear a mask or respirator. […] You may need medicines for successful treatment. The same medicines are used to treat both occupational and nonoccupational asthma. […] The right medicine for you depends on many things. These include your age, symptoms, asthma triggers and what seems to work best to keep your asthma under control. […] Long-term control medicines include inhaled corticosteroids, leukotriene modifiers, long-acting beta agonists (LABAs), and combination inhalers. […] Quick-relief, short-term medications include short-acting beta agonists and oral and intravenous corticosteroids.
  • #21 About Work-related Asthma | Asthma | CDC
    https://www.cdc.gov/niosh/asthma/about/index.html
    Work-related asthma is asthma triggered by exposures at work. To control it, avoid triggers that cause asthma symptoms and take prescribed medicine. […] The most important step of managing asthma is stopping or reducing exposure to triggers causing symptoms. Work with your doctor to develop a personal asthma control plan. Medical professionals often treat asthma with two general types of medicine: Quick-relief rescue inhalers (e.g., albuterol, levalbuterol) to open the airways. People use these medicines to treat asthma attacks or flare-ups. Quick relief medications are often used in combination with long-term control medicines such inhaled corticosteroids. […] Long-term control medicines to reduce inflammation in the airways. People use these medicines to help keep asthma symptoms from occurring. When these medicines are working well, quick relief medicine is not used as much.
  • #22 Occupational asthma – Diagnosis and treatment – Mayo Clinic
    https://www.mayoclinic.org/diseases-conditions/occupational-asthma/diagnosis-treatment/drc-20375777
    The goal of treatment is to prevent symptoms and stop an asthma attack in progress. […] Avoiding the workplace substance that causes your symptoms is important. Once you become sensitive to a substance, tiny amounts may trigger asthma symptoms, even if you wear a mask or respirator. […] You may need medicines for successful treatment. The same medicines are used to treat both occupational and nonoccupational asthma. […] The right medicine for you depends on many things. These include your age, symptoms, asthma triggers and what seems to work best to keep your asthma under control. […] Long-term control medicines include inhaled corticosteroids, leukotriene modifiers, long-acting beta agonists (LABAs), and combination inhalers. […] Quick-relief, short-term medications include short-acting beta agonists and oral and intravenous corticosteroids.
  • #23 Occupational asthma // Middlesex Health
    https://middlesexhealth.org/learning-center/diseases-and-conditions/occupational-asthma
    Avoiding triggers is important for managing occupational asthma. Treatment includes medicines that reduce symptoms. […] You may need medicines for successful treatment. The same medicines are used to treat both occupational and nonoccupational asthma. […] The right medicine for you depends on many things. These include your age, symptoms, asthma triggers and what seems to work best to keep your asthma under control. […] Long-term control medicines include inhaled corticosteroids, leukotriene modifiers, long-acting beta agonists (LABAs), and combination inhalers. […] Quick-relief, short-term medications include short-acting beta agonists and oral and intravenous corticosteroids. […] If allergies trigger or worsen your asthma, you may benefit from allergy treatments. These treatments include medicines taken by mouth or with a nasal spray. Antihistamines help block some immune system activity that causes allergy symptoms. Decongestants help relieve a stuffy nose. […] The goal of treatment is to prevent symptoms and stop an asthma attack in progress.
  • #24 Occupational Asthma: Causes, Symptoms & Treatment
    https://my.clevelandclinic.org/health/diseases/9572-asthma-occupational–work-related-asthma
    Occupational asthma makes it hard to breathe when you work with substances that cause your airways to swell. Treatments can help, but the best way to reduce your risk of an asthma attack is to avoid triggers. […] Most people manage asthma with daily inhalers. These devices combine a medication that reduces inflammation (steroid) with a bronchodilator, which opens up your airways. Your provider will recommend avoiding things that trigger asthma as much as possible. […] Your provider might also prescribe: A rescue inhaler. You’ll likely carry an inhaler that contains a fast-acting bronchodilator, like albuterol, in case you have an asthma attack. A nebulizer. Nebulizers spray a fine mist of medication through a mask on your face. You might use a nebulizer rather than an inhaler for some medications. Leukotriene modifiers. Your provider might prescribe a daily pill to help reduce asthma symptoms and your risk of an asthma attack. Biologic therapy. You might need additional medications if you have severe symptoms that don’t respond to other treatments.
  • #25 Occupational Asthma Causes, Diagnosis, Treatment & Symptoms
    https://www.emedicinehealth.com/occupational_asthma/article_em.htm
    Rescue medications: These are for short-term control of asthma attacks. You take these only when you are having symptoms or are more likely to have an attack; for example, when you have an infection in your respiratory tract. […] Your treatment plan will also include the following: Awareness of your trigger and avoiding the trigger as much as possible, Recommendations for coping with asthma in your daily life, Regular follow-up visits to your health-care provider to monitor your condition, whether you are on medication or not. […] Together, you and your health-care practitioner will develop an action plan for you in case of asthma attack. The action plan will include the following: How to use rescue medication, What to do if the rescue medication does not work right away, When to call the health-care provider, When to go directly to a hospital emergency department.
  • #26 Occupational asthma – Diagnosis and treatment – Mayo Clinic
    https://www.mayoclinic.org/diseases-conditions/occupational-asthma/diagnosis-treatment/drc-20375777
    The goal of treatment is to prevent symptoms and stop an asthma attack in progress. […] Avoiding the workplace substance that causes your symptoms is important. Once you become sensitive to a substance, tiny amounts may trigger asthma symptoms, even if you wear a mask or respirator. […] You may need medicines for successful treatment. The same medicines are used to treat both occupational and nonoccupational asthma. […] The right medicine for you depends on many things. These include your age, symptoms, asthma triggers and what seems to work best to keep your asthma under control. […] Long-term control medicines include inhaled corticosteroids, leukotriene modifiers, long-acting beta agonists (LABAs), and combination inhalers. […] Quick-relief, short-term medications include short-acting beta agonists and oral and intravenous corticosteroids.
  • #27 Work-Related Asthma – Lung and Airway Disorders – Merck Manual Consumer Version
    https://www.merckmanuals.com/home/lung-and-airway-disorders/environmental-and-occupational-lung-diseases/work-related-asthma
    Work-related asthma may cause shortness of breath, tightness in the chest, wheezing, and coughing. […] Treatment involves avoiding the trigger and, when that is not possible, using medications to open the airways and reduce inflammation. […] In addition to reducing or eliminating exposures at work, medical treatments are the same as for other types of asthma. Medications that open the airways (bronchodilators) may be given, preferably in an inhaler (for example, albuterol). Medications that reduce inflammation may be given, either in an inhaler (for example, the corticosteroid triamcinolone) or as a tablet (for example, montelukast). For severe attacks, corticosteroids such as prednisone may be taken by mouth for a short time. For long-term management, inhaled corticosteroids are preferred to oral corticosteroids.
  • #28 Occupational asthma – Diagnosis and treatment – Mayo Clinic
    https://www.mayoclinic.org/diseases-conditions/occupational-asthma/diagnosis-treatment/drc-20375777
    If you need to use a quick-relief inhaler more often than recommended, you may need to adjust your long-term control medicine. […] Also, if allergies trigger or worsen your asthma, you may benefit from allergy treatments. These treatments include medicines taken by mouth or with a nasal spray. Antihistamines help block some immune system activity that causes allergy symptoms. Decongestants help relieve a stuffy nose.
  • #29 Occupational Asthma: Causes, Symptoms & Treatment
    https://my.clevelandclinic.org/health/diseases/9572-asthma-occupational–work-related-asthma
    Occupational asthma makes it hard to breathe when you work with substances that cause your airways to swell. Treatments can help, but the best way to reduce your risk of an asthma attack is to avoid triggers. […] Most people manage asthma with daily inhalers. These devices combine a medication that reduces inflammation (steroid) with a bronchodilator, which opens up your airways. Your provider will recommend avoiding things that trigger asthma as much as possible. […] Your provider might also prescribe: A rescue inhaler. You’ll likely carry an inhaler that contains a fast-acting bronchodilator, like albuterol, in case you have an asthma attack. A nebulizer. Nebulizers spray a fine mist of medication through a mask on your face. You might use a nebulizer rather than an inhaler for some medications. Leukotriene modifiers. Your provider might prescribe a daily pill to help reduce asthma symptoms and your risk of an asthma attack. Biologic therapy. You might need additional medications if you have severe symptoms that don’t respond to other treatments.
  • #30 Asthma Treatment & Management: Approach Considerations, Environmental Control, Allergen Immunotherapy
    https://emedicine.medscape.com/article/296301-treatment
    Medical care includes treatment of acute asthmatic episodes and control of chronic symptoms, including nocturnal and exercise-induced asthmatic symptoms. Pharmacologic management includes the use of control agents such as inhaled corticosteroids, long-acting bronchodilators (beta-agonists and anticholinergics), theophylline, leukotriene modifiers, and more recent strategies such as the use of anti-immunoglobulin E (IgE) antibodies (omalizumab), antiIL5 antibodies, and antiIL4/IL13 antibodies in selected patients. Relief medications include short-acting bronchodilators, systemic corticosteroids, and ipratropium. […] The 2019 Global Initiative for Asthma (GINA) guidelines identify inhaled corticosteroids (ICS) as the preferred controller medication of choice for children and adults and they are now the initial first-line therapy for treatment of asthma.
  • #31 Asthma Medication and Treatment
    https://allergyasthmanetwork.org/what-is-asthma/how-is-asthma-treated/
    Combination medications combine two or even three medications into one inhaler. The devices may contain an anti-inflammatory inhaled corticosteroids, a SABA, LABA or LAMA. Combination medications are typically used daily. […] Biologic medications target cells, pathways and proteins that cause inflammation in the body. These medications focus on treating the source of symptoms rather than the symptoms themselves. They aim to stop symptoms before they can start by targeting inflammation in the body at its source. […] Bronchial thermoplasty is an outpatient surgical procedure. It is for adults ages 18 and older with poor asthma control. These people have severe persistent asthma symptoms despite using standard therapy. […] If you have severe and difficult-to-control asthma, talk with your doctor to determine if bronchial thermoplasty is right for you.
  • #32 Asthma Medication and Treatment
    https://allergyasthmanetwork.org/what-is-asthma/how-is-asthma-treated/
    Combination medications combine two or even three medications into one inhaler. The devices may contain an anti-inflammatory inhaled corticosteroids, a SABA, LABA or LAMA. Combination medications are typically used daily. […] Biologic medications target cells, pathways and proteins that cause inflammation in the body. These medications focus on treating the source of symptoms rather than the symptoms themselves. They aim to stop symptoms before they can start by targeting inflammation in the body at its source. […] Bronchial thermoplasty is an outpatient surgical procedure. It is for adults ages 18 and older with poor asthma control. These people have severe persistent asthma symptoms despite using standard therapy. […] If you have severe and difficult-to-control asthma, talk with your doctor to determine if bronchial thermoplasty is right for you.
  • #33 Asthma Treatment & Management: Approach Considerations, Environmental Control, Allergen Immunotherapy
    https://emedicine.medscape.com/article/296301-treatment
    The most recent guidelines (GINA and NAEPP) recommend the use of a single inhaler containing the combination of an ICS and formoteral, an long-acting bronchodilator for both maintenance and quick relief therapy (single maintenance and reliever therapy (SMART or MART). […] In general, patients should be assessed every 1-6 months for asthma control. At every visit, adherence, environmental control, and comorbid conditions should be checked. If the patient has good control of their asthma for at least 3 months, treatment can be stepped down; however, the patient should be reassessed in 2-4 weeks to make sure that control is maintained with the new treatment. […] Allergen immunotherapy should be considered if specific allergens have a proven relationship to symptoms and a vaccine to the allergen is available; the individual is sensitized (ie, positive skin test or RAST findings); the allergen cannot be avoided and is present year-round (eg, industrial); or symptoms are poorly controlled with medical therapy.
  • #34 Workplace Asthma: Common Triggers, Diagnosis, and TreatmentShare to Facebookprint pageBookmark for latercaret iconFollow us on facebookFollow us on instagramFollow us on facebookFollow us on linkedincaret icon
    https://asthma.net/types/occupational
    Diagnosing workplace asthma is important. Once your doctor connects asthma symptoms to your work, you can find a treatment plan. Treatment usually involves drugs to manage symptoms and reducing exposure at work. […] Avoiding exposure to the work-related trigger is the best way to treat workplace asthma. This may include: […] However, it is not always possible to change jobs or reduce exposure at work. In these situations, your doctor can recommend asthma drugs. They may suggest quick-relief drugs (bronchodilators) that help relax the airway. They may also suggest controller drugs that you take every day to prevent and manage symptoms. […] For some people, allergy shots (allergen immunotherapy) may help. This involves exposing you to increasing doses of the allergen to decrease your sensitivity. This is only recommended if you know what allergen is causing symptoms. […] Maintaining a healthy lifestyle may also reduce your risk of workplace asthma. Some ways to reduce the risk of asthma attacks include: […] Get emergency help if your symptoms become severe. Some signs of an asthma attack that need emergency treatment include:
  • #35 British Thoracic Society Clinical Statement on occupational asthma | Thorax
    https://thorax.bmj.com/content/77/5/433
    This British Thoracic Society (BTS) Clinical Statement addresses occupational asthma and includes key clinical practice points. […] Health surveillance is a form of workplace screening that can identify OA cases early. In the UK, it usually consists of an annual symptom questionnaire and spirometry. […] Managing patients with OA can be complex and should wherever possible be carried out by a physician with specialist expertise in this condition. […] It is important to educate patients with OA that the best opportunity for improved asthma control comes from early, and complete, cessation of exposure to the cause. […] Management of OA includes standard pharmacotherapy, asthma education and smoking cessation advice, following national guidelines. […] Patients with OA may have coexisting and related conditions (eg, occupational rhinitis, breathing pattern disorder, inducible laryngeal obstruction (ILO), anxiety and depression) that require assessment and treatment.
  • #36 British Thoracic Society Clinical Statement on occupational asthma | Thorax
    https://thorax.bmj.com/content/77/5/433
    This British Thoracic Society (BTS) Clinical Statement addresses occupational asthma and includes key clinical practice points. […] Health surveillance is a form of workplace screening that can identify OA cases early. In the UK, it usually consists of an annual symptom questionnaire and spirometry. […] Managing patients with OA can be complex and should wherever possible be carried out by a physician with specialist expertise in this condition. […] It is important to educate patients with OA that the best opportunity for improved asthma control comes from early, and complete, cessation of exposure to the cause. […] Management of OA includes standard pharmacotherapy, asthma education and smoking cessation advice, following national guidelines. […] Patients with OA may have coexisting and related conditions (eg, occupational rhinitis, breathing pattern disorder, inducible laryngeal obstruction (ILO), anxiety and depression) that require assessment and treatment.
  • #37 British Thoracic Society Clinical Statement on occupational asthma | Thorax
    https://thorax.bmj.com/content/77/5/433
    Clinicians should work in partnership with patients to develop (and adapt as necessary) a personalised management plan aiming for the best possible balance between long-term health and employment outcomes. […] Patients with OA should be provided with written information confirming their diagnosis, the implications this has on their current and future jobs as well as Industrial Injuries Disablement Benefit (IIDB) and civil compensation advice. […] While there is potential for ongoing exposure to the cause, patients with OA should remain under specialist follow-up to monitor asthma control, lung function and the impact of any workplace interventions. […] A diagnosis of OA has important health and employment implications and should not be made based on a compatible history alone. […] The diagnosis of OA is most easily made prior to workplace adaptations and starting maintenance treatment.
  • #38 Work-Related Asthma – Pulmonary Disorders – Merck Manual Professional Edition
    https://www.merckmanuals.com/professional/pulmonary-disorders/environmental-and-occupational-pulmonary-diseases/work-related-asthma
    Treatment of Work-Related Asthma […] The pharmacologic treatment of work-related asthma is similar to that of other types of asthma. For all types of work-related asthma, triggering exposures and conditions in the workplace and at home should be minimized. Patients should be monitored for worsening asthma symptoms and increasing medication use. […] With sensitizer-induced occupational asthma, once sensitized, patients can react to extremely low levels of airborne exposure. Thus, the recommended management consists of identification of and complete removal from further exposure to the sensitizing agent. Given that complete removal from the workplace can involve substantial socioeconomic consequences, transfer to a different work area at the same workplace or improving engineering controls is sometimes tried. In situations with potential for ongoing exposure to the sensitizer, close monitoring for worsening asthma is essential, including symptoms, medication usage and lung function. Early recognition and prompt removal from the sensitizing agent result in better outcomes, but asthma commonly persists away from the sensitizing agent.
  • #39 Occupational asthma | Asthma + Lung UK
    https://www.asthmaandlung.org.uk/conditions/asthma/occupational-asthma
    If you have occupational asthma, the best thing to do if you can is to stop exposure to the substance that has caused it. Around 3 in 10 people with occupational asthma who stop being exposed to the harmful substance make a full recovery. […] The treatment for occupational asthma is the same as for asthma that is not related to work. Find out more about treatment for asthma. […] Under the Equality Act 2010, your employer must make reasonable adjustments for you if you have occupational asthma. Your doctor will ask for your consent to contact your employer about this. A reasonable adjustment may involve your employer: replacing the substance that has caused the occupational asthma with a safe alternative, moving you to a role where you will not be exposed to the harmful substance. […] If you develop occupational asthma, your employer must control your exposure to the substance that caused it, to prevent triggering an asthma attack.
  • #40 Work and Asthma | American Lung Association
    https://www.lung.org/lung-health-diseases/lung-disease-lookup/asthma/managing-asthma/workplace
    Your employer is legally responsible for informing you of general and specific hazards connected with your job. Your employer is also responsible for providing you with a safe and healthful workplace. […] If you are experiencing a breathing problem at work, encourage your employer to take steps to creating a lung-friendly workplace.
  • #41 Work and Asthma | American Lung Association
    https://www.lung.org/lung-health-diseases/lung-disease-lookup/asthma/managing-asthma/workplace
    Your employer is legally responsible for informing you of general and specific hazards connected with your job. Your employer is also responsible for providing you with a safe and healthful workplace. […] If you are experiencing a breathing problem at work, encourage your employer to take steps to creating a lung-friendly workplace.
  • #42 Occupational asthma – Symptoms and causes – Mayo Clinic
    https://www.mayoclinic.org/diseases-conditions/occupational-asthma/symptoms-causes/syc-20375772
    Avoiding triggers is important for managing occupational asthma. Treatment includes medicines that reduce symptoms. […] Medicines may help relieve symptoms and control inflammation linked to occupational asthma. But you can do several things on your own to be healthy and lessen the possibility of attacks: […] If you are in the United States and you have a high-risk job, your company must follow rules to help protect you from harmful chemicals. Under guidelines from the Occupational Safety and Health Administration (OSHA), your employer is required to do the following: […] Under OSHA guidelines, your employer is required to keep a material safety data sheet (MSDS) for each harmful chemical used in your workplace. This is a document that must be submitted by the chemical’s manufacturer to your employer. You have a legal right to see and copy such documents. If you suspect you’re allergic to a certain substance, show the MSDS to your healthcare professional.
  • #43 Work-Related Asthma – Pulmonary Disorders – Merck Manual Professional Edition
    https://www.merckmanuals.com/professional/pulmonary-disorders/environmental-and-occupational-pulmonary-diseases/work-related-asthma
    Treatment of Work-Related Asthma […] The pharmacologic treatment of work-related asthma is similar to that of other types of asthma. For all types of work-related asthma, triggering exposures and conditions in the workplace and at home should be minimized. Patients should be monitored for worsening asthma symptoms and increasing medication use. […] With sensitizer-induced occupational asthma, once sensitized, patients can react to extremely low levels of airborne exposure. Thus, the recommended management consists of identification of and complete removal from further exposure to the sensitizing agent. Given that complete removal from the workplace can involve substantial socioeconomic consequences, transfer to a different work area at the same workplace or improving engineering controls is sometimes tried. In situations with potential for ongoing exposure to the sensitizer, close monitoring for worsening asthma is essential, including symptoms, medication usage and lung function. Early recognition and prompt removal from the sensitizing agent result in better outcomes, but asthma commonly persists away from the sensitizing agent.
  • #44 Work-Related Asthma – Pulmonary Disorders – Merck Manual Professional Edition
    https://www.merckmanuals.com/professional/pulmonary-disorders/environmental-and-occupational-pulmonary-diseases/work-related-asthma
    For patients with irritant-induced occupational asthma and work-exacerbated asthma, the hope is that workers can continue their current jobs if adequate measures are implemented to reduce triggering exposures and conditions. These include better engineering controls of irritant exposures and accommodations to avoid certain job tasks or locations, such as work in a hot or cold room. Regular monitoring of asthma symptoms and control is important. If the patients asthma worsens at work, further work modifications, including change in employment, may be necessary. Standard asthma treatment, including pharmacologic treatment and minimizing home and environmental triggers, is recommended. […] Both sensitizer-induced and irritant-induced asthma commonly persists even when patients are away from the causative exposure, and patients may require long-term use of asthma medications. Clinicians should document the diagnosis of work-related asthma and specific causative factors before making recommendations about work.
  • #45 Work-Related Asthma – Pulmonary Disorders – Merck Manual Professional Edition
    https://www.merckmanuals.com/professional/pulmonary-disorders/environmental-and-occupational-pulmonary-diseases/work-related-asthma
    Treatment of Work-Related Asthma […] The pharmacologic treatment of work-related asthma is similar to that of other types of asthma. For all types of work-related asthma, triggering exposures and conditions in the workplace and at home should be minimized. Patients should be monitored for worsening asthma symptoms and increasing medication use. […] With sensitizer-induced occupational asthma, once sensitized, patients can react to extremely low levels of airborne exposure. Thus, the recommended management consists of identification of and complete removal from further exposure to the sensitizing agent. Given that complete removal from the workplace can involve substantial socioeconomic consequences, transfer to a different work area at the same workplace or improving engineering controls is sometimes tried. In situations with potential for ongoing exposure to the sensitizer, close monitoring for worsening asthma is essential, including symptoms, medication usage and lung function. Early recognition and prompt removal from the sensitizing agent result in better outcomes, but asthma commonly persists away from the sensitizing agent.
  • #46 Work-Related Asthma – Pulmonary Disorders – Merck Manual Professional Edition
    https://www.merckmanuals.com/professional/pulmonary-disorders/environmental-and-occupational-pulmonary-diseases/work-related-asthma
    Treatment of Work-Related Asthma […] The pharmacologic treatment of work-related asthma is similar to that of other types of asthma. For all types of work-related asthma, triggering exposures and conditions in the workplace and at home should be minimized. Patients should be monitored for worsening asthma symptoms and increasing medication use. […] With sensitizer-induced occupational asthma, once sensitized, patients can react to extremely low levels of airborne exposure. Thus, the recommended management consists of identification of and complete removal from further exposure to the sensitizing agent. Given that complete removal from the workplace can involve substantial socioeconomic consequences, transfer to a different work area at the same workplace or improving engineering controls is sometimes tried. In situations with potential for ongoing exposure to the sensitizer, close monitoring for worsening asthma is essential, including symptoms, medication usage and lung function. Early recognition and prompt removal from the sensitizing agent result in better outcomes, but asthma commonly persists away from the sensitizing agent.
  • #47 Work-Related Asthma – Pulmonary Disorders – Merck Manual Professional Edition
    https://www.merckmanuals.com/professional/pulmonary-disorders/environmental-and-occupational-pulmonary-diseases/work-related-asthma
    For patients with irritant-induced occupational asthma and work-exacerbated asthma, the hope is that workers can continue their current jobs if adequate measures are implemented to reduce triggering exposures and conditions. These include better engineering controls of irritant exposures and accommodations to avoid certain job tasks or locations, such as work in a hot or cold room. Regular monitoring of asthma symptoms and control is important. If the patients asthma worsens at work, further work modifications, including change in employment, may be necessary. Standard asthma treatment, including pharmacologic treatment and minimizing home and environmental triggers, is recommended. […] Both sensitizer-induced and irritant-induced asthma commonly persists even when patients are away from the causative exposure, and patients may require long-term use of asthma medications. Clinicians should document the diagnosis of work-related asthma and specific causative factors before making recommendations about work.
  • #48 Work-Related Asthma – Pulmonary Disorders – Merck Manual Professional Edition
    https://www.merckmanuals.com/professional/pulmonary-disorders/environmental-and-occupational-pulmonary-diseases/work-related-asthma
    For patients with irritant-induced occupational asthma and work-exacerbated asthma, the hope is that workers can continue their current jobs if adequate measures are implemented to reduce triggering exposures and conditions. These include better engineering controls of irritant exposures and accommodations to avoid certain job tasks or locations, such as work in a hot or cold room. Regular monitoring of asthma symptoms and control is important. If the patients asthma worsens at work, further work modifications, including change in employment, may be necessary. Standard asthma treatment, including pharmacologic treatment and minimizing home and environmental triggers, is recommended. […] Both sensitizer-induced and irritant-induced asthma commonly persists even when patients are away from the causative exposure, and patients may require long-term use of asthma medications. Clinicians should document the diagnosis of work-related asthma and specific causative factors before making recommendations about work.
  • #49 Occupational asthma: Management, prognosis, and prevention – UpToDate
    https://www.uptodate.com/contents/occupational-asthma-management-prognosis-and-prevention
    Occupational asthma (OA) is a form of work-related asthma that is characterized by variable airflow limitation, airway hyperresponsiveness, and airway inflammation induced by immunologic or nonimmunologic exposures in the work environment. The management, prognosis, and prevention of OA will be reviewed here. […] The key element is to make the diagnosis and remove the subject from exposure as quickly as possible after the onset of symptoms, as a long duration of exposure is associated with a poor prognosis of the disease. Although asthma is persistent in the majority of subjects even after removal from exposure, OA may be cured in some cases if removal from exposure occurs early following onset of symptoms. The management of OA requires a combination of avoidance of further exposure to sensitizing agents, reduction in exposure to irritant agents (eg, environmental tobacco smoke, strong fumes and fragrances, extremes of temperature and humidity) and pharmacotherapy based on the severity of asthma.
  • #50 Occupational asthma: Management, prognosis, and prevention – UpToDate
    https://www.uptodate.com/contents/occupational-asthma-management-prognosis-and-prevention
    Occupational asthma (OA) is a form of work-related asthma that is characterized by variable airflow limitation, airway hyperresponsiveness, and airway inflammation induced by immunologic or nonimmunologic exposures in the work environment. The management, prognosis, and prevention of OA will be reviewed here. […] The key element is to make the diagnosis and remove the subject from exposure as quickly as possible after the onset of symptoms, as a long duration of exposure is associated with a poor prognosis of the disease. Although asthma is persistent in the majority of subjects even after removal from exposure, OA may be cured in some cases if removal from exposure occurs early following onset of symptoms. The management of OA requires a combination of avoidance of further exposure to sensitizing agents, reduction in exposure to irritant agents (eg, environmental tobacco smoke, strong fumes and fragrances, extremes of temperature and humidity) and pharmacotherapy based on the severity of asthma.
  • #51 Work-Related Asthma – Pulmonary Disorders – Merck Manual Professional Edition
    https://www.merckmanuals.com/professional/pulmonary-disorders/environmental-and-occupational-pulmonary-diseases/work-related-asthma
    For patients with irritant-induced occupational asthma and work-exacerbated asthma, the hope is that workers can continue their current jobs if adequate measures are implemented to reduce triggering exposures and conditions. These include better engineering controls of irritant exposures and accommodations to avoid certain job tasks or locations, such as work in a hot or cold room. Regular monitoring of asthma symptoms and control is important. If the patients asthma worsens at work, further work modifications, including change in employment, may be necessary. Standard asthma treatment, including pharmacologic treatment and minimizing home and environmental triggers, is recommended. […] Both sensitizer-induced and irritant-induced asthma commonly persists even when patients are away from the causative exposure, and patients may require long-term use of asthma medications. Clinicians should document the diagnosis of work-related asthma and specific causative factors before making recommendations about work.
  • #52 Occupational asthma | Asthma + Lung UK
    https://www.asthmaandlung.org.uk/conditions/asthma/occupational-asthma
    If you have occupational asthma, the best thing to do if you can is to stop exposure to the substance that has caused it. Around 3 in 10 people with occupational asthma who stop being exposed to the harmful substance make a full recovery. […] The treatment for occupational asthma is the same as for asthma that is not related to work. Find out more about treatment for asthma. […] Under the Equality Act 2010, your employer must make reasonable adjustments for you if you have occupational asthma. Your doctor will ask for your consent to contact your employer about this. A reasonable adjustment may involve your employer: replacing the substance that has caused the occupational asthma with a safe alternative, moving you to a role where you will not be exposed to the harmful substance. […] If you develop occupational asthma, your employer must control your exposure to the substance that caused it, to prevent triggering an asthma attack.
  • #53 Occupational Asthma
    https://www.aaaai.org/tools-for-the-public/conditions-library/asthma/occupational-asthma
    Once the cause of your symptoms is identified, develop a treatment plan with your doctor and talk to your employer to avoid exposure to that substance. If occupational asthma is not correctly diagnosed early, and you aren’t protected or removed from the exposure, it can cause permanent changes to your lungs.
  • #54 Work-Related Asthma – Pulmonary Disorders – Merck Manual Professional Edition
    https://www.merckmanuals.com/professional/pulmonary-disorders/environmental-and-occupational-pulmonary-diseases/work-related-asthma
    […] […] Key Points […] Work-related asthma should be considered in all adults with new-onset or worsening asthma. Diagnosis consists in clarifying the diagnosis of asthma, identifying workplace exposures associated with asthma, and clarifying the temporal relationship between asthma and work. Triggering exposures and conditions at work and at home should be minimized to the extent possible. The pharmacological treatment of work-related asthma is similar to treatment of other types of asthma.
  • #55 Occupational asthma – Symptoms, diagnosis and treatment | BMJ Best Practice US
    https://bestpractice.bmj.com/topics/en-us/1111
    Occupational asthma (OA) should be suspected in all adult patients with asthma. […] In sensitizer-induced OA, removal from any further exposure to that agent is recommended if an immunologic response to the work sensitizer is demonstrated by skin or in vitro tests. […] In irritant-induced OA, preventive measures should be implemented in the workplace to reduce future exposures and episodes. […] For all causes of OA, the clinician should continue treating the asthma as appropriate, assist in the initiation of any appropriate compensation claim, and consider other workers at risk.
  • #56 British Thoracic Society Clinical Statement on occupational asthma | Thorax
    https://thorax.bmj.com/content/77/5/433
    This British Thoracic Society (BTS) Clinical Statement addresses occupational asthma and includes key clinical practice points. […] Health surveillance is a form of workplace screening that can identify OA cases early. In the UK, it usually consists of an annual symptom questionnaire and spirometry. […] Managing patients with OA can be complex and should wherever possible be carried out by a physician with specialist expertise in this condition. […] It is important to educate patients with OA that the best opportunity for improved asthma control comes from early, and complete, cessation of exposure to the cause. […] Management of OA includes standard pharmacotherapy, asthma education and smoking cessation advice, following national guidelines. […] Patients with OA may have coexisting and related conditions (eg, occupational rhinitis, breathing pattern disorder, inducible laryngeal obstruction (ILO), anxiety and depression) that require assessment and treatment.
  • #57 Occupational asthma – Symptoms, diagnosis and treatment | BMJ Best Practice US
    https://bestpractice.bmj.com/topics/en-us/1111
    Occupational asthma (OA) should be suspected in all adult patients with asthma. […] In sensitizer-induced OA, removal from any further exposure to that agent is recommended if an immunologic response to the work sensitizer is demonstrated by skin or in vitro tests. […] In irritant-induced OA, preventive measures should be implemented in the workplace to reduce future exposures and episodes. […] For all causes of OA, the clinician should continue treating the asthma as appropriate, assist in the initiation of any appropriate compensation claim, and consider other workers at risk.
  • #58 Work-Related Asthma – Pulmonary Disorders – Merck Manual Professional Edition
    https://www.merckmanuals.com/professional/pulmonary-disorders/environmental-and-occupational-pulmonary-diseases/work-related-asthma
    For patients with irritant-induced occupational asthma and work-exacerbated asthma, the hope is that workers can continue their current jobs if adequate measures are implemented to reduce triggering exposures and conditions. These include better engineering controls of irritant exposures and accommodations to avoid certain job tasks or locations, such as work in a hot or cold room. Regular monitoring of asthma symptoms and control is important. If the patients asthma worsens at work, further work modifications, including change in employment, may be necessary. Standard asthma treatment, including pharmacologic treatment and minimizing home and environmental triggers, is recommended. […] Both sensitizer-induced and irritant-induced asthma commonly persists even when patients are away from the causative exposure, and patients may require long-term use of asthma medications. Clinicians should document the diagnosis of work-related asthma and specific causative factors before making recommendations about work.
  • #59 British Thoracic Society Clinical Statement on occupational asthma | Thorax
    https://thorax.bmj.com/content/77/5/433
    Clinicians should work in partnership with patients to develop (and adapt as necessary) a personalised management plan aiming for the best possible balance between long-term health and employment outcomes. […] Patients with OA should be provided with written information confirming their diagnosis, the implications this has on their current and future jobs as well as Industrial Injuries Disablement Benefit (IIDB) and civil compensation advice. […] While there is potential for ongoing exposure to the cause, patients with OA should remain under specialist follow-up to monitor asthma control, lung function and the impact of any workplace interventions. […] A diagnosis of OA has important health and employment implications and should not be made based on a compatible history alone. […] The diagnosis of OA is most easily made prior to workplace adaptations and starting maintenance treatment.