Materiały źródłowe

• #1 Vitiligo: Diagnosis and treatment

  https://www.aad.org/public/diseases/a-z/vitiligo-treatment

  If you want to treat vitiligo, dermatologists have treatments that can restore lost skin color. […] There is no one best treatment for vitiligo. […] To do this, your dermatologist considers your age, overall health, and the effects the disease has on your life. […] If you decide to treat vitiligo, its important to know the following: Treatment works slowly. […] Treatment cannot cure vitiligo. […] Here are the treatments that dermatologists consider for their patients who have vitiligo. […] Several prescription medications that you apply to your skin are used to treat vitiligo. […] One of the most common side effects is feeling a burning sensation when you apply this medication. […] Light therapy exposes your skin to a type of ultraviolet (UV) light that can restore your natural skin color.

• #1 Vitiligo: Current Therapies and Future Treatments

  https://pmc.ncbi.nlm.nih.gov/articles/PMC10824325/

  The current management of vitiligo remains challenging; however, different strategies can be proposed to patients with a good efficacy in many cases. […] For patients with a stable disease, the treatment strategy is now well-stratified and is based on a combination of phototherapy (natural or in a cabin) and topical immunomodulatory agents. […] The recent approval of topical ruxolitinib cream in both the US and Europe brings new approaches for the management of vitiligo and paves the way for the development of new topical or oral targeted drugs. […] Treatment strategies depend on several clinical characteristics, such as disease subtype, the extent of vitiligo, and disease activity. […] The management of vitiligo should encompass three main complementary objectives: 1) halting disease progression, 2) inducing repigmentation, melanocyte regeneration and proliferation, and 3) maintaining repigmentation and preventing disease recurrence.

• #1 Vitiligo: Current Therapies and Future Treatments

  https://pmc.ncbi.nlm.nih.gov/articles/PMC10824325/

  It is essential to detect active forms of vitiligo because a treatment aiming to block flare-ups must be initiated urgently. […] However, clinical signs of disease activity have been identified, such as inflammatory borders, the Koebner phenomenon, hypochromic areas/borders, and confetti-like depigmentation. […] While data are primarily based on open or retrospective studies, it is now widely accepted that the treatment for patients with highly progressive disease should combine systemic therapies and phototherapy. […] To date, the systemic therapy mainly relies on mini-pulses of systemic steroids for 3 to 6 months. […] Systemic steroids should be combined with phototherapy: e.g Narrow band UVB 23 times/week for 6 months. […] With current strategies, complete or near complete repigmentation could be achieved.

• #1 Vitiligo Treatments at UMass Chan Medical School

  https://www.umassmed.edu/vitiligo/vitiligo-treatment/

  There are a number of treatments available for vitiligo, and the type of treatment should be tailored for each patient, according to his or her needs. […] Topical steroids are widely available and have been used for many years to treat vitiligo. […] Topical tacrolimus is a relatively new treatment for vitiligo that has similar efficacy as topical steroids and few side effects that include a mild burning sensation after application and brief flushing of the skin after alcohol consumption. […] nbUVB is currently the most successful treatment for patients with vitiligo. […] The excimer laser is similar a similar approach to treatment as narrow band UVB, but delivers a single wavelength of light (which is what lasers do). […] In a small subset of patients with vitiligo, transplanting melanocytes and keratinocytes from one part of your body to the areas of vitiligo can be a highly effective treatment, and even a cure.

• #1 Vitiligo Treatment & Management: Approach Considerations, Medical Care, Surgical Care

  https://emedicine.medscape.com/article/1068962-treatment

  PUVA has largely been replaced by NB-UVB, which is highly effective and has fewer adverse effects. Literature reviews from 2017 have shown that NB-UVB therapy has an overall better response than therapy with PUVA. […] The excimer laser produces monochromatic rays at 308 nm to treat limited, stable patches of vitiligo. This new treatment is an efficacious, safe, and well-tolerated treatment for vitiligo. However, therapy is expensive. Localized lesions of vitiligo are treated twice weekly for an average of 24-48 sessions. […] Topical corticosteroid preparation is often chosen as a first-line treatment for localized vitiligo because it is easy and convenient for patients. The results of therapy have been reported as moderately successful, particularly in patients with localized vitiligo and/or an inflammatory component to their vitiligo.

• #1 Vitiligo: Causes, Symptoms, and Treatment | Doctor

  https://patient.info/doctor/vitiligo-pro

  These can be used in adults and children. […] Effective in widespread NSV. […] Some studies show benefit in fast-spreading vitiligo to arrest progress. […] Surgical treatment options include: Non-cultured melanocyte-keratinocyte cell transplantation. […] This is an option for dark-skinned people, who have large areas of skin affected.

• #1 Topical treatment in vitiligo and the potential uses of new drug delivery systems – Indian Journal of Dermatology, Venereology and Leprology

  https://ijdvl.com/topical-treatment-in-vitiligo-and-the-potential-uses-of-new-drug-delivery-systems/

  Medical treatment targets the immune system and helps to arrest the spread of depigmentation. […] The best studied and most commonly used medical treatment options are corticosteroids, psoralens and depigmenting agents. […] Topical steroids are often first-line therapy, especially in children or for localized disease. Moderately potent to potent topical corticosteroids are used. […] However, vitiligo requires prolonged use of these agents, often much longer than the usual „safe” recommended periods of use for inflammatory dermatoses. This results in significant, therapy-limiting side-effects like atrophy, hypertrichosis, peri-lesional hypopigmention etc. It is obvious that currently available dosage formulations do not provide site-specific drug delivery. […] Phototherapy is one of the oldest forms of treatment of vitiligo and remains the bedrock of vitiligo therapy even today.

• #1 Vitiligo: Causes, Symptoms, and Treatment | Doctor

  https://patient.info/doctor/vitiligo-pro

  Vitiligo treatment […] The variety of treatments available suggests that none is totally satisfactory. The response is highly variable between patients. A Cochrane review in 2015 concluded it was not possible to establish which was the best treatment for vitiligo and that further studies are needed. […] Specific treatment is known to be more effective if started early, when the affected area is small, and in childhood. […] General measures as above. […] Consider and discuss the option of no treatment where appropriate. […] Offer prescriptions for high-factor sun cream and camouflage creams where appropriate. […] Consider treatment with a topical corticosteroid if: NSV is localised or limited. […] Topical corticosteroids should not be applied to the face and should not be used in pregnant women.

• #1 Vitiligo Treatment & Management: Approach Considerations, Medical Care, Surgical Care

  https://emedicine.medscape.com/article/1068962-treatment

  Topical JAK inhibitor therapy are an emerging option. Ruxolitinib topical cream gained approval from the FDA in July 2022 for treatment of adults and adolescents aged 12 years and older with nonsegmental vitiligo. Approval was based on data from two Phase 3 trials (TRuE-V1 and TRuE-V2), that evaluated the safety and efficacy of ruxolitinib cream compared with vehicle in more than 600 people. […] Topical tacrolimus ointment (0.03% or 0.1%) and pimecrolimus cream are effective therapies for vitiligo, particularly when the disease involves the head and neck. […] Vitamin D analogs, particularly calcipotriol and tacalcitol, have been used as topical therapeutic agents in vitiligo. […] Afamelanotide is an emerging treatment for vitiligo that is a long-lasting synthetic analog of alpha-melanocytestimulating hormone (-MSH).

• #1 Vitiligo Guidelines: Guidelines Summary

  https://emedicine.medscape.com/article/1068962-guidelines

  Clinical guidelines on the management of vitiligo released in 2021 by the British Association of Dermatologists include, but are not limited to, the following: […] As first-line primary or secondary care treatment, people with vitiligo should be offered a potent or very potent topical corticosteroid once daily, to minimize potential side effects, with avoidance of the periocular area. […] As an alternative to potent or very potent topical corticosteroids in people with facial vitiligo, topical tacrolimus 0.1% ointment twice daily should be considered. […] To arrest the activity of rapidly progressive vitiligo, the use of oral betamethasone should be considered (after the risks and benefits have been carefully weighed), with the drug administered at 0.1mg/kg twice weekly on 2 consecutive days for 3 months; the dose should then be tapered by 1mg per month for an additional 3 months; treatment should be carried out in combination with narrowband ultraviolet B (NB-UVB) therapy.

• #1 Vitiligo – British Skin Foundation

  https://knowyourskin.britishskinfoundation.org.uk/condition/vitiligo/

  There is another type of anti-inflammatory cream and ointment called a calcineurin inhibitor, which may also restore pigment in some patients. […] Short courses of oral corticosteroids can sometimes be considered if you have rapidly spreading vitiligo. […] This involves exposing affected skin to artificial ultraviolet light. Phototherapy may be helpful in a proportion of patients with vitiligo. […] Professional help with developing coping mechanisms may be helpful for some people with vitiligo or their carers e.g. parents. […] There are a number of options for covering up or blending in your patches. […] This process involves transplanting small areas of normal skin into areas of stable (unchanged for over a year) vitiligo. […] Some areas of vitiligo have improved from treatment with a laser called the Excimer laser. […] If vitiligo has spread very widely (more than 50% of the body) or involves large areas of the face or hands, it may in exceptional circumstances be reasonable to consider removing the small amounts of remaining pigmented areas of skin using a bleaching chemical such as hydroquinone.

• #1 Vitiligo Treatments | Diagnosis & Next Steps | Vitiligo Society

  https://vitiligosociety.org/vitiligo-treatments/

  Protopic, also known as tacrolimus, ointment is a treatment that has mainly been used for eczema. However, recently, protopic have also been used in clinical studies for the treatment of vitiligo. […] Using Protopic as a vitiligo treatment usually involves applying the ointment twice a day. […] Protopic ointment has proved quite effective on the faces of some people who have vitiligo, when the loss of pigment is relatively recent and still active. […] Current research is looking at the effectiveness of using protopic with Narrow Band UVB light treatment. […] JAK inhibitors are medicines that affect your immune system. Opzelura (Ruxolitnib) is the only current MRHA approved (July 2023) treatment of this kind available in the UK, and it is currently undergoing approval from NICE for availability through the NHS.

• #1 Vitiligo: Current Therapies and Future Treatments

  https://pmc.ncbi.nlm.nih.gov/articles/PMC10824325/

  Importantly, the treatment should be evaluated after at least 6 months. […] Topical immunomodulatory treatments are important. […] The topical JAK-inhibitor ruxolitinib is the first treatment approved for vitiligo both in US and Europe for the management of vitiligo affecting the face and less than 10% of the body surface area for adults and adolescents. […] A combination of sun exposure with immunomodulating agents is crucial to achieve good repigmentation. […] There are now well-established recommendations for using phototherapy in patients with vitiligo. […] For instance for the face, it has been shown than the use of tacrolimus 0.1% twice weekly reduces the risk of relapse from 40% to 9.7%. […] Depigmentation can be discussed for patients with depigmented areas affecting more than 50% of the body. […] Patients with vitiligo should be informed on therapeutic options available to treat their conditions. […] Topical ruxolitinib cream is now approved for vitiligo and this will open the development of other topical and/or systemic treatments for the disease.

• #1 Vitiligo > Fact Sheets > Yale Medicine

  https://www.yalemedicine.org/conditions/vitiligo

  Topical therapy: Topical steroids and topical calcineurin inhibitors are sometimes effective to restore pigment when small areas of skin are affected by vitiligo. […] Bleaching treatments: When treatment to achieve repigmentation is unsuccessful, sometimes patients with vitiligo decide to remove or depigment existing skin pigment so that their white patches blend together and are less noticeable. […] For example, Dr. King has pioneered the use of a class of medicines called JAK inhibitors for treatment of the disorder. He showed that a medicine originally intended for rheumatoid arthritis can restore normal skin pigment for patients with vitiligo. In 2022, the FDA approved a topical JAK inhibitor (ruxolitinib cream) for the treatment of vitiligo in both adult and pediatric patients (down to age 12 years). This represents the first FDA-approved treatment for vitiligo, and is part of the complement of vitiligo therapies offered by Yale Medicine dermatologists.

• #1 FDA approves topical treatment addressing repigmentation in vitiligo in patients aged 12 and older | FDA

  https://www.fda.gov/drugs/news-events-human-drugs/fda-approves-topical-treatment-addressing-repigmentation-vitiligo-patients-aged-12-and-older

  FDA has approved Opzelura (ruxolitinib) cream for the treatment of nonsegmental vitiligo in adult and pediatric patients 12 years of age and older. […] Opzelura is the first FDA-approved pharmacologic treatment to address repigmentation in vitiligo patients. […] Satisfactory patient response may require treatment with Opzelura for more than 24 weeks. […] Safety and effectiveness of Opzelura were demonstrated in two clinical trials, NCT04052425 and NCT04057573. […] At the end of the 24-week treatment period, 30% of Opzelura patients had at least 75% improvement in the facial Vitiligo Area Scoring Index, compared with 10% of placebo patients.

• #1 Treatments – Global Vitiligo Foundation

  https://globalvitiligofoundation.org/treatments/

  Monobenzone is a compounded cream used for medical depigmentation. […] Topical Ruxolitinib (Opzelura) is a Janus Kinase 1,2 inhibitor approved by the FDA in 2022 for treatment of vitiligo in individuals aged 12 and older. […] PUVA stands for Psoralen plus UltraViolet A light, and is a form of phototherapy using long wave UVA light in combination with either a photosensitizing pill or a topical solution known as a psoralen. […] NB-UVB, now considered the gold standard of treatment for vitiligo, is a more recent vitiligo treatment than PUVA, and uses the portion of the UVB spectrum from 311-313 nm. […] The excimer laser is a targeted NB machine typically using the 308 nm portion of the UVB spectrum. […] Oral steroids are used to help stabilize active vitiligo, meaning that they help stop new spots of vitiligo from developing.

• #1 Treatment for Nonsegmental Vitiligo | OPZELURA® (ruxolitinib)

  https://www.opzelura.com/vitiligo/

  OPZELURA may cause serious side effects, including: Serious infections: OPZELURA contains ruxolitinib. Ruxolitinib belongs to a class of medicines called Janus kinase (JAK) inhibitors. JAK inhibitors are medicines that affect your immune system. JAK inhibitors can lower the ability of your immune system to fight infections. […] OPZELURA may increase your risk of certain cancers by changing the way your immune system works. […] With using OPZELURA cream, we’ve had great results for some patients with nonsegmental vitiligo and I knew that it would be a great option for you. […] Results may vary. Across two 6-month studies, 29.9% of those using OPZELURA saw 75% improvement to vitiligo on the face compared with 7.5% and 12.9% of those using placebo. […] Repigmentation may continue beyond 6 months. If meaningful repigmentation is not achieved after 6 months, please consult your healthcare provider.

• #1 Treatment for Nonsegmental Vitiligo | OPZELURA® (ruxolitinib)

  https://www.opzelura.com/vitiligo/

  THE FIRST AND ONLY FDA-APPROVED PRESCRIPTION TREATMENT FOR NONSEGMENTAL VITILIGO TO HELP REPIGMENT SKIN. OPZELURA is a prescription cream for the topical treatment of nonsegmental vitiligo in patients aged 12 and older. The use of OPZELURA along with therapeutic biologics, other JAK inhibitors, or strong immunosuppressants such as azathioprine or cyclosporine is not recommended. […] If you want to restore your pigment, pursue it with OPZELURA. […] OPZELURA is a prescription medicine used on the skin (topical) for the treatment of a type of vitiligo called nonsegmental vitiligo in adults and children 12 years of age and older. […] The use of OPZELURA along with therapeutic biologics, other JAK inhibitors, or strong immunosuppressants such as azathioprine or cyclosporine is not recommended.

• #1 Treatment for Vitiligo | Saguaro Dermatology | Phoenix, AZ

  https://saguaroderm.com/services/medical-dermatology/vitiligo/

  Traditionally, two topical steroids, 0.I% betamethasone valerate and 0.05% clobetasol propionate creams, have been successful at bringing some color back to depigmented skin. […] These are medicines that help your immune system function properly. […] These are synthesized drugs that work by increasing vitamin D levels in your body and helping it to absorb more calcium. […] PUVA is a treatment that combines ultraviolet (UV) radiation treatment (phototherapy) with a compound in plants called psoralens. […] There are a number of surgical therapies, all of which are complicated and used only after other therapies fail. […] When therapies to restore color to the skin fail, a kind of reverse vitiligo treatment can be done. […] Finally, while combination vitiligo treatments have been used for several decades, a new combination therapy has been reported that promises dramatic results.

• #1

  https://dpcj.org/index.php/dpc/article/view/4600

  Baricitinib is Effective in Treating Progressing Vitiligo in vivo and in vitro. […] Efficacy and safety of oral ritlecitinib for the treatment of active nonsegmental vitiligo: A randomized phase 2b clinical trial. […] Topical ruxolitinib: A new treatment for vitiligo. […] Advances in vitiligo: Update on therapeutic targets. […] Therapeutic options in vitiligo with special emphasis on immunomodulators: A comprehensive update with review of literature. […] Comparison of efficacy and safety of 0.005% calcipotriol ointment versus 0.05% betamethasone dipropionate ointment versus calcipotriol plus betamethasone ointment for the treatment of vitiligo. […] Microneedling in vitiligo: A systematic review. […] Efficacy of topical vitamin D combined with microneedling in the treatment of vitiligo: A comparative study.

• #1 Vitiligo Treatment & Management: Approach Considerations, Medical Care, Surgical Care

  https://emedicine.medscape.com/article/1068962-treatment

  Phototherapy induces satisfactory repigmentation in a majority of patients with early or localized disease. Prolonged phototherapy courses should be encouraged, as a treatment period of at least 6 months may be necessary to accurately assess the responsiveness to the phototherapy. […] Narrowband UV-B (NB-UVB) is widely used and has become the first choice of phototherapy for adults and children with generalized vitiligo. Wavelengths of 311-312 nm typically are used. Treatment frequency is 2-3 times weekly. This treatment can be safely used in children, pregnant women, and lactating women. […] Psoralen photochemotherapy involves the use of psoralens combined with UV-A radiation and is also known as PUVA. Psoralens can be applied either topically or taken orally, followed by exposure to artificial UV-A radiation or natural sunlight.

• #1 Vitiligo – Diagnosis & treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/vitiligo/diagnosis-treatment/drc-20355916

  Phototherapy with narrow band ultraviolet B (UVB) has been shown to stop or slow the progression of active vitiligo. […] This treatment combines a plant-derived substance called psoralen with light therapy (photochemotherapy) to return color to the light patches. […] This therapy may be an option if your vitiligo is widespread and other treatments haven’t worked. […] If light therapy and medications haven’t worked, some people with stable disease may be candidates for surgery. […] Treatments being studied include a drug to stimulate color-producing cells (melanocytes). […] A drug that helps control melanocytes is being tested as a way to restore skin color in people with vitiligo that isn’t widespread or spreading.

• #1 Vitiligo: Causes, Types, and Treatment — DermNet

  https://dermnetnz.org/topics/vitiligo

  Treatment is most successful on the face and trunk; whereas hands, feet, and areas with white hair respond poorly. […] While the hair follicle is the main source of pigment restoration, another potential reservoir can be at the borders of the white patches. […] Treatment response is evaluated in terms of proportion of skin that has retained pigment. […] A cut, graze, or scratch may lead to a new patch of vitiligo. […] There are several modalities that are proven to be helpful in vitiligo. Optimal therapeutic response is often seen with combination therapies. […] Phototherapy refers to treatment with ultraviolet (UV) radiation. […] Phototherapy probably works in vitiligo by two mechanisms. […] Systemic therapy includes short pulse therapy to slow rapid progression, or as mini-pulse oral steroids to stabilize active disease.

• #1 Reddit – The heart of the internet

  https://www.reddit.com/r/Vitiligo/comments/1c5eak2/vitiligo_beginner_guide_current_treatment_options/

  Most people see some improvement within 3 months, with even better results between 4 months and a year. […] UVB light therapy has been around for a while and involves directing focused UVB light onto the areas affected by vitiligo to induce repigmentation, which actually works quite well. […] The good news: After at least 6 months of treatment, 7 out of 10 people (74%) saw at least some improvement in their skin condition. […] Nearly a fifth (19%) of people had significant improvement after 6 months, and this number went up to over a third (36%) at 1 year. […] The location of the improvement mattered. The treatment worked best on the face and neck (almost half – 44% – saw significant improvement after 6 months), followed by the torso (trunk – 26%). […] The first thing a doctor prescribed me at the time was topical steroids, which are applied to the areas affected by vitiligo in a similar way to Opzelura.

• #1 Treatments – Global Vitiligo Foundation

  https://globalvitiligofoundation.org/treatments/

  Topical therapy is usually not very expensive. Both topical creams and in-office light therapy are often covered by medical insurance but usually require a small co-pay amount. However, surgical procedures are not covered by insurance at this time. […] Research has shown that NB-UVB eyelid phototherapy is a safe and effective treatment and does not penetrate the eyelid. […] Generally, use of topical steroids in widespread vitiligo is considered impractical because of the greater risk of associated adverse side effects due to the significant amount of skin that would be treated. […] Tacrolimus and pimecrolimus are both classified as immunomodulators, and are prescribed in their topical form for vitiligo. […] Pseudocatalase is an antioxidant that is prescribed in its topical form for the treatment of vitiligo.

• #1 Everything you need to know about the use of phototherapy for treating vitiligo – The Vitiligo Society

  https://vitiligosociety.org/vitlife/everything-you-need-to-know-about-the-use-of-phototherapy-for-treating-vitiligo/

  Phototherapy means treatment with light. For vitiligo, there are two main categories of phototherapy: narrow-band ultraviolet B (NB-UVB) and psoralen ultraviolet A (PUVA) light treatments. […] Although both NB-UVB and PUVA are effective, NB-UVB is the treatment of choice because it has been found to result in higher repigmentation rates and better colour match, and it is less likely to cause side compared to PUVA. […] Phototherapy is thought to suppress DNA synthesis which results in reduced inflammation, and to stimulate the production of melanocytes. […] After being prescribed phototherapy, you will go to hospital-based appointments 2-3 times a week, depending on your response and the treatment availability. […] Phototherapy should last for a minimum of 6 months as thats the time it may take to for some repigmentation to occur.

• #1 Treatments – Global Vitiligo Foundation

  https://globalvitiligofoundation.org/treatments/

  Areas with hair follicles repigment fastest and with best results (e.g. face, upper arms, upper legs, chest, back, buttocks). The wrists, hands, and feet are the slowest to respond to treatment. […] You will generally start to see results with light therapy after 24-36 treatments. However, the best results may require 6 months or longer of continued treatment. Maximum improvement may require 1-2 years of treatment. […] Treatment is not abruptly discontinued. The frequency of the light therapy treatments is usually tapered as the skin begins to reach maximum repigmentation until you are receiving 1 treatment every other week. At this point, if no new lesions occur, you may discontinue treatment. […] Sunlight, while not the most effective therapy, can be used to treat vitiligo if a prescription light source is not available.

• #1 Phototherapy & Laser Treatment for Vitiligo | NYU Langone Health

  https://nyulangone.org/conditions/vitiligo/treatments/phototherapy-laser-treatment-for-vitiligo

  NYU Langone has an onsite phototherapy center that offers full-body phototherapy in as little as 5 to 10 minutes. For people with mild vitiligo, four sessions per month may help shrink the size of existing light patches of skin and may prevent new patches from developing. For people with moderate to severe vitiligo, dermatologists may recommend two or three sessions per week. […] The excimer laser is a highly focused beam of UVB light. Dermatologists focus the laser directly on the lightened areas of skin using a wand-like device. The UVB light may stimulate repigmentation in the skin, restoring color to white patches. […] Multiple sessions are usually required to achieve the desired results, and dermatologists may suggest twice-weekly sessions for four to six months before determining whether further treatment is required.

• #1 Learn About Vitiligo

  https://www.xtracclear.com/learn-more/learn-about-vitiligo/

  Safe, Highly Effective, and Virtually No Side Effects […] You may see clearance of your Vitiligo in as few as 3 months* […] Fortunately, XTRAC treatments can minimize, and in many cases, even eliminate vitiligo depigmented patches. The XTRAC excimer laser delivers a targeted beam of UVB light and only the areas of skin affected by vitiligo receive the laser energy. […] Other studies have concluded that when XTRAC is used as monotherapy, repigmentation of rates greater than 75% are seen in more than 50% of patients but response rates as high as 95% have been achieved, It has also been noted that repigmentation can be seen in as few as 11 treatments. […] XTRAC is the #1 Targeted Therapy for Vitiligo by Dermatologists in Thousands of Convenient Locations. Contact Us at 1-800-974-8958 Today to Find A Physician Near You that offers XTRAC Therapy.

• #1 Vitiligo Treatment: From Ointments to Depigmentation

  https://www.healthline.com/health/vitiligo-treatment

  Prednisone is an oral prescription medication that may help slow the progression of active vitiligo. […] Light therapy uses controlled ultraviolet (UV) light exposure to restore the skin color. […] Skin grafting involves a dermatological surgeon removing pigmented skin from one area of the body and transplanting it to one of the areas affected by vitiligo. […] Blister grafting also involves transplanting small portions of your skin. […] In cell transplants, a surgeon removes pigmented skin from an area not affected by vitiligo. […] Depigmentation is rarely used. […] While natural treatments may help, a small 2017 review of 14 cases suggests that they may be more effective in the early stages of vitiligo. […] While there’s no cure for vitiligo, treatments can help prevent the progression of this autoimmune disease.

• #1 Current Treatment Options for Vitiligo

  https://www.hcplive.com/view/current-treatment-options-for-vitiligo

  I do combination therapy. […] the data shows that it tends to work best above the neck, basically on the face. […] I consider it like a vitiligo emergency and in those patients, I will use systemic corticosteroids. […] dexamethasone has been shown to have the best evidence of good response as well as lower side effects. […] I find that’s particularly helpful as Amit said for preventing progression of disease and stabilizing it, but not as helpful at the repigmentation process itself. […] we’re going to use topical corticosteroids, topical calcineurin inhibitors, if possible, in combination with phototherapy.

• #1 Vitiligo Treatment & Management: Approach Considerations, Medical Care, Surgical Care

  https://emedicine.medscape.com/article/1068962-treatment

  Oral tofacitinib and other JAK inhibitors have revolutionized the treatment of vitiligo. […] If vitiligo is widespread and attempts at repigmentation do not produce satisfactory results, depigmentation may be attempted in very carefully selected patients. […] Surgical alternatives exist for the treatment of vitiligo; however, because of the time-consuming nature of surgical therapies, these treatment regimens are limited to segmental vitiligo or localized vitiligo that is limited to a small region. […] The surgical treatment of vitiligo can be classified according to the type of graft as tissue grafting and cellular grafting technique. […] Micropigmentation is another option. Tattooing can be used to repigment depigmented skin in dark-skinned individuals.

• #1 What is Vitiligo | Treatments for Vitiligo | Vitiligo Causes

  https://www.sinclairdermatology.com.au/treatments/vitiligo/

  Complete repigmentation has been reported in up to 90% of cases when combined with adjuvant phototherapy. […] Case reports of repigmentation in patients with refractory vitiligo following treatment with oral tofacitinib, ruxolitinib and baricitinib have appeared in the literature over the past 3 years. These agents are Janus kinase (JAK) inhibitors.

• #1 Combined Oral and Phototherapy Treatments Show Promise in Treating Severe Vitiligo

  https://www.managedhealthcareexecutive.com/view/combined-oral-and-phototherapy-treatments-show-promise-in-treating-severe-vitiligo

  At week 36, participants in the baricitinib group had a 44.8% reduction in VASI scores compared to 9.2% in the placebo group. […] While this didn’t significantly exceed the target improvement of 42.9%, further research displayed benefits of combining baricitinib with NB-UVB therapy. […] Baricitinib also improved disease control and quality of life, with no major differences in side effects compared to the placebo. […] Regardless of limitations including the small sample size, the findings support further research in larger phase 3 trials to confirm these results and assess long-term safety, according to researchers.

• #1 New and Upcoming Treatment for Vitiligo, Atopic Dermatitis

  https://www.ajmc.com/view/new-and-upcoming-treatment-for-vitiligo-atopic-dermatitis

  The panel featured a segment on vitiligo that was led by Seemal R. Desai, MD, FAAD, clinical assistant professor in the Department of Dermatology at the University of Texas Southwestern Medical Center. […] Desai started by going through different categories of treatment, the first being topical therapy, the second of systemic therapeutic, and the last being procedural. […] When it comes to topical therapy there are treatments including steroids, vitamin D analogues, and calcineurin inhibitors. Vitiligo is not a mono-therapy disease. […] Stabilizing vitiligo is the most important thing before starting on continued treatment. […] Systemic steroids have been shown to stabilize vitiligo and theres promising data for oral janus kinase (JAK) inhibitors to treat unstable vitiligo. […] Desai said that theres a lot of excitement about JAK inhibitors being used for vitiligo treatment, as the JAK inhibitors can shut down the interferon that causes vitiligo.

• #1 Vitiligo and Repigmentation Options | MyVitiligoTeam

  https://www.myvitiligoteam.com/resources/treatments-for-vitiligo

  Calcipotriol, also known as calcipotriene, is a medication derived from vitamin D. […] In cases where vitiligo is spreading slowly, doctors may prescribe minocycline or gingko biloba extract to be taken orally. […] For many individuals with vitiligo, doctors may recommend phototherapy, also known as light therapy. […] Narrowband UVB (NB-UVB) phototherapy is the light treatment of choice for generalized, nonsegmental vitiligo, which is the most common type of vitiligo. […] In cases where medication and phototherapy are not effective in treating generalized vitiligo, surgical procedures may be considered. […] There are several surgical techniques used to treat vitiligo, most of which involve transferring skin or skin cells from an area of skin that is still pigmented to a depigmented area.

• #1 Treatments – Global Vitiligo Foundation

  https://globalvitiligofoundation.org/treatments/

  Minocycline is an antibiotic that is used to treat many skin conditions. In vitiligo, it has been shown to stabilize active disease when taken daily. […] Vitiligo surgery has the goal of transplanting functional melanocytes (pigment cells) to the depigmented area to cause repigmentation. […] Although medical therapy has improved considerably in the last years, some people fail to sufficiently repigment through medical treatment. Surgical therapy can provide higher re-pigmentation rates for difficult-to-treat localized areas in selected patients, and can be used to treat generalized disease as well.

• #1 Treatments | Vitiligo | Henry Ford Health – Detroit, MI

  https://www.henryford.com/services/skin/treatments/rare-conditions/vitiligo/treatments

  Ultraviolet light therapy is the treatment of choice for patients with widespread vitiligo. […] The typical response is seen as islands of freckles in the affected skin that will grow in size. […] PUVA involves taking an oral or topical medication (psoralen) followed by being placed in a light booth and exposed to ultraviolet A light. […] Surgical treatment involves transferring intact skin or individual cells from an unaffected area of your body to the area of vitiligo. […] Special prescription bleaching creams are an option for those who have extensive loss of pigment and/or who do not respond to treatment. […] Ginkgo biloba is an herbal medication that may have an effect on generalized vitiligo.

• #1 Vitiligo Treatment: 16 Natural Ways to Improve Pigmentation – Dr. Axe

  https://draxe.com/health/vitiligo-treatment/

  The best types of vitiligo treatment whether conventional or natural all take time to work. […] Skin needling is showing some promise as a leading vitiligo natural treatment. […] A two-year study conducted at University Hospital in Sweden found that over half of the participants in the trial experienced repigmentation when combining vitamin B12, folic acid, and sun exposure. […] Another common deficiency found in those with this condition is zinc. […] While researchers disagree on whether copper deficiency causes vitiligo or is a result of vitiligo, adding copper-rich foods to your diet may be beneficial. […] Topical application of a mixture of turmeric powder and mustard oil may result in positive changes in the pigment of the skin. […] One of the most important vitiligo treatments is to manage stress.

• #1 Vitiligo: Diagnosis, Treatment, and Steps to Take

  https://www.niams.nih.gov/health-topics/vitiligo/diagnosis-treatment-and-steps-to-take

  Your doctor may prescribe a medication that focuses on stopping the immune system from destroying the melanocytes and improving the skins appearance. In most cases, the goals of your treatment are to: […] Treatments can include: […] Medicines or medicated skin creams, such as corticosteroids or a calcineurin inhibitor, which may be able to return color to the white patches of skin. […] Use of light (phototherapy) to help return color to the skin. […] Dermatologists may consider surgical techniques for long-standing segmental vitiligo or vitiligo of any type for which other treatments do not work.

• #1 Regenerative Medicine-Based Treatment for Vitiligo: An Overview

  https://www.mdpi.com/2227-9059/10/11/2744

  Surgical therapeutic modalities are effective interventions for patients with stable vitiligo who have experienced failure of medical treatment. […] Surgical transplantation modalities for vitiligo patients are classified according to the nature of the grafted material (punch graft, split-thickness skin grafts, smashed skin grafting, blister graft) and cellular grafts (cultured and noncultured cells). […] Unlike tissue grafting, cellular grafting permits treatment of a depigmented skin area significantly larger than the harvesting area. […] The main advantage of a noncultured epidermal cell suspension graft consists of the possibility to treat a large area using a small sized portion of donor skin (1:10 donor–recipient size ratio). […] The field of regenerative medicine encompasses numerous strategies to overcome physiological as well as pathological limited regenerative capacity in adult humans. […] The biological basis for regenerative therapeutic approaches is to enhance the intrinsic regenerative capacity of pathologic tissue or to replace damaged/missing cells by immature committed cells or a pluripotent stem precursor cells graft. […] The treatment of vitiligo is one of the most difficult dermatological challenges. […] Regenerative medicine offers new therapeutic opportunity intrinsically related to its reparative character.

• #1 Breakthroughs offer hope for vitiligo patients | UCI Health | Orange County, CA

  https://www.ucihealth.org/blog/2023/06/vitiligo-breakthroughs

  Skin specialists Dr. Anand K. Ganesan and Dr. Jessica Shiu are thrilled that breakthrough vitiligo treatments tested at UCI Health are now available for the disease, which causes white patches where the body’s immune system has attacked pigment-making cells. […] When Dr. Anand K. Ganesan started a vitiligo specialty practice in 2018 at the UCI Health Beckman Laser Institute Medical Clinic, it was to find new therapies to reverse the disfiguring skin disorder. […] A topical cream called ruxolitinib is the first therapy approved by the U.S. Federal Drug Administration (FDA) to restore pigment in vitiligo patients. The FDA also recently gave breakthrough device approval for RECELL, a one-time therapy using the patients healthy cells to stimulate lasting repigmentation in stable vitiligo, the regenerative medicine company Avita Medical announced June 16. Other topical, oral and injectable medications also have shown success at halting progression of the disease in early phase trials.

• #1 Breakthroughs offer hope for vitiligo patients | UCI Health | Orange County, CA

  https://www.ucihealth.org/blog/2023/06/vitiligo-breakthroughs

  We have made a lot of progress, but there is still a lot more work to be done, says Ganesan, who recently was honored by the American Skin Association for his pioneering research on vitiligo. […] The new topical treatment restores pigment on the face in about 60% of patients, although it isn’t as successful for the rest of the body. […] New oral therapies also show promise in stopping disease progression. These treatments, which target the Janus kinase signaling pathway, suppress the body’s T-cell defense systems and may result in long-term side effects. […] Great strides also have been made in skin-grafting techniques and light therapy to stimulate repigmentation. The RECELL treatment involves harvesting the patients healthy melanocytes from a small amount of skin, which is processed to create a solution of skin cells that are applied to white patches of skin prepped by laser ablation.

• #1 Breakthroughs offer hope for vitiligo patients | UCI Health | Orange County, CA

  https://www.ucihealth.org/blog/2023/06/vitiligo-breakthroughs

  Studies showed that more than a third of RECELL participants saw greater than 80% repigmentation 24 weeks after treatment, while over half of patients saw greater than 50% repigmentation over the same period. […] The hope is that RECELL will become a procedure any dermatologist could perform with very limited training, Ganesan says. […] Light therapy, too, has become more accessible. Treatments that required intensive daily or weekly office visits now can be done at home. […] One patient I’ve been treating since she was about 8 years old is a teenager now. Being able to do the treatment at home has been a godsend! […] Ganesan has a lot to share at the next quarterly vitiligo support group meeting, which went on hiatus during the COVID-19 pandemic. […] One of the most fulfilling things we do is work with our patients to learn how they are affected by the disease. We use that information to design better treatments for them.

• #1 Vitiligo: Diagnosis and treatment

  https://www.aad.org/public/diseases/a-z/vitiligo-treatment

  If other treatments fail to restore skin color, surgery may be an option. […] Depigmentation is rarely used. […] Many treatments described above are used to treat children. […] Maintenance therapy helps to prevent this color loss. […] To maintain results, dermatologists often prescribe a medication that you apply to your skin a few times per week.

• #1 Topical treatment in vitiligo and the potential uses of new drug delivery systems – Indian Journal of Dermatology, Venereology and Leprology

  https://ijdvl.com/topical-treatment-in-vitiligo-and-the-potential-uses-of-new-drug-delivery-systems/

  Recently, calcium modulators, the vitamin D3 analogues (calcipotriol and tacalcitol), have also been tried in the treatment of vitiligo. […] Calcineurin inhibitors (tacrolimus, pimecrolimus) are some of the newest topical drugs in dermatology. […] The main difficulty with topical calcineurin inhibitors, and one that is probably responsible for lack of efficacy in non-facial vitiligo, is their high molecular weight. […] Hence, carrier mediated drug delivery can substantially increase their effectiveness bypassing the stratum corneum barrier and delivering these drugs in adequate concentration to the melanocytes and keratinocytes. […] Depigmentation is a more drastic form of treatment, when vitiligo is extensive i.e. vitiligo universalis. […] In contrast to the traditional oral route, topical drug delivery for vitiligo has many advantages. It bypasses all major organ systems like GIT, liver, kidney etc. there by avoiding many issues of adverse effects, bioavailability etc.

• #1

  https://www.nhs.uk/conditions/vitiligo/treatment/

  Phototherapy (treatment with light) may be used for children or adults if: topical treatments have not worked, the vitiligo is widespread, the vitiligo is having a significant impact on your quality of life. […] Evidence suggests that phototherapy, particularly when combined with other treatments, has a positive effect on vitiligo. […] A skin graft is a surgical procedure where healthy skin is removed from an unaffected area of the body and used to cover an area where the skin has been damaged or lost. […] Depigmentation may be recommended for adults who have vitiligo on more than 50% of their bodies, although it may not be widely available. […] A dermatologist may recommend trying more than 1 treatment, such as phototherapy combined with a topical treatment. […] Some complementary therapies claim to relieve or prevent vitiligo. However, there’s no evidence to support their effectiveness, so more research is needed before they can be recommended. […] Many treatments used for vitiligo are unlicensed. „Unlicensed” means the medicine’s manufacturer has not applied for a licence for it to be used to treat your condition.

• #1 Vitiligo: Causes, Types, and Treatment — DermNet

  https://dermnetnz.org/topics/vitiligo

  Surgical treatment for stable and segmental vitiligo requires removal of the top layer of vitiligo skin and replacement with pigmented skin removed from another site. […] Depigmentation therapy, using 20% monobenzyl ether of hydroquinone (MBEH), may be considered in severely affected, dark-skinned individuals with vitiligo that has failed to re-pigment spontaneously or with therapy. […] Other novel potential therapies that are still under research include those targeting IFN-JAKSTAT1 pathway, anti-IL15 and anti-CD122, Wnt signalling antagonists, and others. […] Patients should be assured that there is always something on the table to help in managing their condition, from using camouflage to available therapies with possible measurable improvement.

• #1 Depigmentation therapy for vitiligo

  https://dermnetnz.org/topics/depigmentation-therapy-for-vitiligo

  Depigmentation therapy refers to medical treatments that remove skin pigmentation causing contact leukoderma. Depigmentation therapy is used in someone that has widespread, but incomplete, vitiligo on the face and/or other sites, in an attempt to improve their appearance. […] Depigmentation therapy may be considered in the management of treatment-resistant vitiligo affecting more than 50% of the body surface area or affecting cosmetically sensitive, exposed body sites. […] MBEH or monobenzone is the most commonly used depigmenting agent used in vitiligo. It is the only depigmentation treatment for extensive vitiligo that has been approved by the FDA (Food and Drug Agency, United States of America). […] Depigmentation is usually achieved after 14 months, however it may take up to 12 months for complete depigmentation of a particular site.

• #1 Depigmentation therapy for vitiligo

  https://dermnetnz.org/topics/depigmentation-therapy-for-vitiligo

  There are some reports that MBEH or MMEH combined with a topical retinoid such as tretinoin may overcome treatment resistance and enhance treatment efficacy. Retinoids help by inhibiting the melanocyte enzyme glutathione S-transferase. […] MBEH or MMEH may also be used in combination with cryotherapy, or laser treatment.

• #1 Vitiligo and Repigmentation Options | MyVitiligoTeam

  https://www.myvitiligoteam.com/resources/treatments-for-vitiligo

  New, experimental treatments for vitiligo are being studied in clinical trials. […] Some people with vitiligo choose to try complementary or natural treatments. […] After successful treatments produce repigmentation, your doctor may recommend a period of maintenance therapy to prevent a relapse of vitiligo. […] In adults who have little pigment left, and for whom other vitiligo treatments haven’t worked, depigmentation may be an option. […] Monobenzone (Benoquin) is approved by the FDA to remove pigment in people with vitiligo that covers more than 50 percent of their body. […] Whether or not you choose to treat your vitiligo, you can take steps to protect your skin and make your white patches less noticeable. […] People with vitiligo may face social stigma that can be psychologically devastating. […] Several studies have shown that types of psychotherapy including cognitive-behavioral therapy, group therapy, and self-help programs have benefited people suffering under the emotional burden of vitiligo.

• #1 The Clinical Landscape of Vitiligo Treatment – LiVDerm

  https://www.livderm.org/the-clinical-landscape-of-vitiligo-treatment/

  Numerous studies have shown that combining various therapies provides more effective outcomes for vitiligo treatment. […] According to Seemal R. Desai, MD, FAAD, “Although improvements have been made with monotherapy topicals, the combination of phototherapy, oral antioxidants, and oral and topical medications together are what’s needed.” […] It is essential for providers to evaluate each patient’s unique circumstances in a comprehensive manner, considering the many factors involved. […] Furthermore, personalized treatment plans may be necessary to optimize outcomes and improve the quality of life for individuals living with vitiligo.

• #1 Mount Sinai Dermatologists Show Promising Results Using Combination Therapy for Vitiligo Patients | Mount Sinai – New York

  https://www.mountsinai.org/about/newsroom/2025/mount-sinai-dermatologists-show-promising-results-using-combination-therapy-for-vitiligo-patients

  In a 24-week extension of a phase 2b clinical trial, the Mount Sinai researchers found that patients receiving ritlecitinib with nbUVB phototherapy experienced greater improvements in vitiligo severity compared to those receiving ritlecitinib alone. Notably, the combination led to a mean 69.6 percent improvement in facial repigmentation, compared to 55.1 percent with ritlecitinib alone. Total body repigmentation also improved more significantly with the combination therapy. […] “These results are encouraging and suggest that this combination may provide added benefit for patients with vitiligo,” said Dr. Guttman-Yassky. “Our findings underscore the potential of precision therapies, including targeted oral treatments, to be safely integrated with traditional modalities like light therapy to enhance patient outcomes.”

• #1 Reddit – The heart of the internet

  https://www.reddit.com/r/Vitiligo/comments/1c5eak2/vitiligo_beginner_guide_current_treatment_options/

  I have noticed a huge improvement in my vitiligo progression after reaching a healthy weight, exercising regularly, and spending time in the sauna. […] Microneedling in combination with other treatments such as topical creams or UVB light therapy may be superior to UVB or topical creams alone. […] Again, I am not a doctor, please see your doctor first, but it seems that combining different treatments offers the greatest chance of success. […] There are many different treatment options that are currently being researched, some of which I have already mentioned in the treatment section. […] Although I don’t have scientifically verifiable evidence for it, based on medical advancements, I believe that vitiligo will become a highly treatable disease in the next 5-10 years.

• #1 Microbial therapy offers new hope for vitiligo patients – Northwestern Now

  https://news.northwestern.edu/stories/2025/01/microbial-therapy-offers-new-hope-for-vitiligo-patients/

  Microbial therapy offers new hope for vitiligo patients. A natural compound derived from gut-friendly bacteria significantly slows the progression of vitiligo and may restore pigmentation, reports a new Northwestern University pre-clinical study in mice. We found that administering a microbial compound weekly to vitiligo-prone mice significantly suppressed disease progression. This simple microbial compound could work as a standalone therapy, or in synergy with existing treatments. Our findings about the effectiveness of microbial therapy could give hope to patients who are not well-served by existing treatments. The next challenge is adapting the microbial product for human use.

• #1 Microbial Therapy Offers New Hope for Vitiligo Patients – News Center

  https://news.feinberg.northwestern.edu/2025/01/31/microbial-therapy-offers-new-hope-for-vitiligo-patients/

  Northwestern researchers have found that a new microbial therapy could offer hope to millions affected by the autoimmune disease vitiligo, which causes visible patches of skin discoloration and carries profound emotional and physical consequences. […] A natural compound derived from gut-friendly bacteria can significantly slow the progression of vitiligo and may restore pigmentation, according to a new Northwestern University pre-clinical study in mice, published in the Journal of Investigative Dermatology. […] We found that administering a microbial compound weekly to vitiligo-prone mice significantly suppressed disease progression. It made a spectacular difference in an aggressive model of the disease, Le Poole said. […] This simple microbial compound could work as a standalone therapy, or in synergy with existing treatments, Le Poole said. […] Our findings about the effectiveness of microbial therapy could give hope to patients who are not well-served by existing treatments, Le Poole said. […] Weekly injections could work, but we need to explore simpler options, like a food additive or ointment, said Le Poole.

• #1 Light and labor-inducing molecule: a new treatment for vitiligo? | Cornell University College of Veterinary Medicine

  https://www.vet.cornell.edu/about-us/news/20240201/light-and-labor-inducing-molecule-new-treatment-vitiligo

  Light and labor-inducing molecule: a new treatment for vitiligo? […] Patients with an appearance-altering skin condition may have relief thanks to an unlikely cocktail of a molecule that induces labor, an immunosuppressant medication and controlled UVB irradiation. […] This discovery, published in Nature Communications and supported by the National Institutes of Health, uses drugs already approved by the FDA, meaning a brand-new treatment for the disease, vitiligo, could be at the doorstep of clinical trials. […] Most existing drugs treat the autoimmune aspect of vitiligo, stopping the destruction of melanocytes. However, these medications rarely lead to a full and long-lasting pigmentation of the skin. […] Using UVB exposure with prostaglandin to treat vitiligo is particularly promising because a form of prostaglandin already exists on the market as a topical gel, used to accelerate labor in humans. […] White filed a provisional patent for his therapeutic strategy, combining the existing immunosuppressant drugs recommended to treat vitiligo to the controlled UVB irradiation and prostaglandin supplementation a three-prong approach that showed the highest melanocyte migration in his mouse models.

• #1 Vitiligo: Management and prognosis – UpToDate

  https://www.uptodate.com/contents/vitiligo-management-and-prognosis

  Vitiligo is a common, acquired, autoimmune, chronic disorder of pigmentation characterized by the development of white macules on the skin due to loss of epidermal melanocytes. […] Although there is no cure for the disease, the available treatments may halt the progression of the disease and induce varying degrees of repigmentation, with acceptable cosmetic results in many cases. […] The management of vitiligo includes systemic corticosteroids, phototherapy, systemic immunosuppressants and immunomodulators, targeted phototherapy, psoralen plus ultraviolet A photochemotherapy, and surgical procedures. […] Maintenance treatment and adjunctive therapies such as topical vitamin D analogues, dietary supplements, and microneedling are also considered. […] Investigational therapies include afamelanotide, prostaglandin E2, prostaglandin F2 analogues, and Janus kinase inhibitors.

• #1 Reddit – The heart of the internet

  https://www.reddit.com/r/Vitiligo/comments/1c5eak2/vitiligo_beginner_guide_current_treatment_options/

  My story: […] Skipping ahead to 2023, my vitiligo had become more prominent and seriously bothered me. I figured I could at least try to look for something that could help me. […] Unfortunately, many dermatologists, at least in my experience here in Germany, aren’t always up to speed on the latest treatment options. So, I can’t stress this enough: do your own research and, if needed, bring new treatment possibilities to your doctor’s attention. It could make all the difference. […] Despite ongoing research and exciting developments in vitiligo treatment, there’s currently no single medication guaranteed to work for everyone. Combining different therapies often yields the best results, but these can be time-consuming and require dedication. The primary goal of current treatments is to manage and potentially improve the affected areas. A definitive cure for vitiligo isn’t yet available.

• #1 Vitiligo Treatment: 16 Natural Ways to Improve Pigmentation – Dr. Axe

  https://draxe.com/health/vitiligo-treatment/

  Vitiligo treatment can take quite a while to work. […] Finding the right vitiligo treatment therapy takes time; even the most common conventional treatments can take weeks, months, or even years before appearance improves. […] Conventional vitiligo treatment such as topical creams, light therapy, photochemotherapy, permanent depigmentation treatments of healthy skin, surgery, and cosmetics are often prescribed. […] As this condition is not infectious nor is it contagious, conventional vitiligo treatments work to restore the skin color, or even-out the overall tone of the skin. […] The most common conventional treatments include: Makeup and Dyes, Corticosteroid Creams, Tacrolimus or Pimecrolimus Ointments, Psoralen and Light Therapy, Depigmenting Agents, Surgery, and JAK Inhibitors.

• #1 Vitiligo Treatment & Management: Approach Considerations, Medical Care, Surgical Care

  https://emedicine.medscape.com/article/1068962-treatment

  Various types of medications, phototherapy, laser therapy, and surgical therapy exist. However, it is important to note that in patients with lighter skin, no intervention may be needed. Instead, diligent sun protection may be the best strategy in order to avoid the surrounding normal skin from becoming more tan and making the lesions more obvious. When therapy is necessary, topical steroids, topical calcineurin inhibitors, and narrow-band ultraviolet (UV)B phototherapy are widely used and are now considered the mainstays of treatment. However, treatment must be individualized and patients should be made aware of the risks associated with therapy. No single therapy for vitiligo produces predictably good results in all patients, and the response to therapy is highly variable. […] Some types of vitiligo or lesions in certain locations may be more or less responsive to treatment. Segmental vitiligo and age of onset younger than 14 years have been associated with more refractory disease. Segmental vitiligo is more responsive to surgical therapy.

• #1 Vitiligo – British Skin Foundation

  https://knowyourskin.britishskinfoundation.org.uk/condition/vitiligo/

  Vitiligo is a persistent or chronic condition in which areas of skin lose their normal pigment (colour) and become very pale, white or light pink. […] The pigment may return partially in some people, through treatment or sometimes without treatment. It is important to note that re-pigmentation (return of colour) is not guaranteed following treatment and the vitiligo may well return after treatment. […] There is no cure for vitiligo. Although treatment may be helpful in restoring your skin colour, it cannot prevent its spread or recurrence and re-pigmentation may not be permanent. […] There are treatment options that can be discussed with your healthcare professional. […] If you do decide to seek treatment for your vitiligo patches, the following options are available. […] The application of a potent or very potent corticosteroid anti-inflammatory cream or ointment to areas of vitiligo may restore some pigment.

• #1 Treating Vitiligo in Children: Can It Go Away? | MyVitiligoTeam

  https://www.myvitiligoteam.com/resources/treating-vitiligo-in-children-your-guide

  If we look at our database of outcomes in children versus my outcomes in adults, one thing we know is that kids have better outcomes. […] When treating a child with vitiligo, Dr. Grimes focuses on three main goals: Slowing or stopping the spread of vitiligo, Restoring color to the affected skin, known as repigmentation, Maintaining color through regular follow-up visits with the child and family. […] The calcineurin inhibitors [such as tacrolimus (Protopic)] work extremely well, she said. […] More recently, topical ruxolitinib (Opzelura) was approved by the U.S. Food and Drug Administration (FDA) for treating vitiligo in people ages 12 and older. […] Although vitiligo may not always go away completely or permanently, Dr. Grimes said she aims to help each child get the best results possible.

• #1 Vitiligo: More than skin deep – Harvard Health

  https://www.health.harvard.edu/blog/vitiligo-more-than-skin-deep-2019092617885

  Vitiligo is a medical condition in which patches of skin lose their color. […] Thus far, there is no cure for vitiligo. But new hope is on the horizon, thanks to recent research that is improving our understanding of the pathways involved in this condition and potential new ways to treat it. […] There are a number of treatments aimed at restoring color to depigmented skin. One of the oldest and most effective treatments is phototherapy (light therapy) with ultraviolet B (UVB) light. […] Light therapy is often used in combination with topical medications that are applied to the skin. […] If medical treatments are ineffective, surgical treatment may be an option for certain people. […] Recently, several exciting studies have looked at a class of medications called JAK inhibitors as a possible new treatment option.

• #1 Vitiligo: Types, Symptoms, Causes, Treatment & Recovery

  https://my.clevelandclinic.org/health/diseases/12419-vitiligo

  Light therapy or phototherapy is the treatment to help return color to your skin. […] Depigmentation therapy removes the color of your natural skin tone to match areas of your skin affected with vitiligo. […] Surgery is a treatment option for people diagnosed with vitiligo. […] Some people diagnosed with vitiligo find counseling or visiting a mental health professional beneficial to help improve their self-esteem, anxiety or depression that can be associated with changes to their skin. […] If you’d like to get treatment, your healthcare provider will help you choose the treatment that’s right for you and your skin.

• #2 Vitiligo – Diagnosis & treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/vitiligo/diagnosis-treatment/drc-20355916

  The choice of treatment depends on your age, how much skin is involved and where, how quickly the disease is progressing, and how it’s affecting your life. […] Medications and light-based therapies are available to help restore skin color or even out skin tone, though results vary and are unpredictable. […] If you and your health care provider decide to treat your condition with a drug, surgery or therapy, the process may take many months to judge its effectiveness. […] Even if treatment is successful for a while, the results may not last or new patches may appear. Your health care provider might recommend a medication applied to the skin as maintenance therapy to help prevent relapse. […] No drug can stop the process of vitiligo the loss of pigment cells (melanocytes). But some drugs, used alone, in combination or with light therapy, can help restore some color.

• #2 Vitiligo – Symptoms & causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/vitiligo/symptoms-causes/syc-20355912

  Vitiligo (vit-ih-LIE-go) is a disease that causes loss of skin color in patches. […] Treatment for vitiligo may restore color to the affected skin. But it doesn’t prevent continued loss of skin color or a recurrence. […] See your health care provider if areas of your skin, hair or mucous membranes lose coloring. Vitiligo has no cure. But treatment might stop or slow the discoloring process and return some color to your skin.

Zobacz więcej