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• #1 Immune thrombocytopenia (ITP) | disease | symptoms | Sobi

  https://www.sobi.com/en/sobi-itp-immune-thrombocytopenia

  Only nine or ten people in every 100,000 have ITP, a rare autoimmune disease affecting platelet production and characterised by fatigue, bruising and bleeding. […] ITP is a rare autoimmune disease characterised by fatigue and increased risk of bleeding caused by not having enough platelets in the blood. […] The symptoms of immune thrombocytopenia can be very different for different individuals. In general, the severity of symptoms will vary according to how far the platelet count is below the normal range. […] If the platelet count is in the range 50,000-150,000 platelets per cubic millimetre of blood there is usually no bleeding or bruising and the patient may not be aware of the condition. […] If the platelet count falls below 50,000 some bruising may occur. […] Below 20,000, bruising and petechiae (pinpoint blood spots under the skin) are more likely.

• #1 Immune thrombocytopenia (ITP) – Symptoms and causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/idiopathic-thrombocytopenic-purpura/symptoms-causes/syc-20352325

  Immune thrombocytopenia (ITP) is an illness that can lead to bruising and bleeding. Low levels of the cells that help blood clot, also known as platelets, most often cause the bleeding. […] Once known as idiopathic thrombocytopenic purpura, ITP can cause purple bruises. It also can cause tiny reddish-purple dots on the skin that look like a rash. […] Immune thrombocytopenia might not have symptoms. When symptoms occur, they might include: Easy bruising. Bleeding into the skin that looks like tiny reddish-purple spots, also known as petechiae. The spots mostly show up on the lower legs. They look like a rash. Bleeding into the skin that’s larger than petechiae, also known as purpura. Bleeding from the gums or nose. Blood in urine or stools. Really heavy menstrual flow. […] Make an appointment with your health care provider if you or your child has symptoms that worry you. Bleeding that won’t stop is a medical emergency. Seek help right away if you or your child has bleeding that the usual first aid efforts can’t control. These include applying pressure to the area. […] Rarely, immune thrombocytopenia causes bleeding into the brain. This can be fatal.

• #1 Immune Thrombocytopenia (ITP): Symptoms, Diagnosis & Treatment

  https://my.clevelandclinic.org/health/diseases/5726-immune-thrombocytopenia

  Immune thrombocytopenia (ITP) is a rare blood disorder that affects how your blood clots. When your blood cant clot, you may bruise easily, bleed more than normal when youre hurt or start bleeding for no reason. Sometimes, ITP goes away without treatment. Other times, its a chronic condition, meaning treatment eases symptoms but doesnt cure it. […] Symptoms include petechia and purpura. Immune thrombocytopenia (ITP) may not cause symptoms. When it does, symptoms may include petechia (left) or purpura (right). […] You may not have any symptoms, but they can happen slowly or quickly if you do. Symptoms may include: […] Petechiae: This symptom appears as tiny red or purple dots on your lower legs that resemble a rash. […] Purpura: This is when petechiae join together, forming red, purple or brown spots on your skin. The spots are larger than petechiae but smaller than a bruise. This happens when small blood vessels under your skin leak blood.

• #1 Immune Thrombocytopenia (ITP): Symptoms, Diagnosis & Treatment

  https://my.clevelandclinic.org/health/diseases/5726-immune-thrombocytopenia

  Bruises: Bruises happen when blood pools under your skin. You may notice youre developing bruises more easily than usual or have bruises you cant explain. […] Bleeding gums: You may notice blood on your toothbrush and your gums may appear swollen. […] Blood in poop (stool): Your poop may appear very dark. […] Blood in urine (pee): If toilet water is pale pink after you pee, you may have blood in your urine. […] Heavy menstrual periods: If your periods last longer than seven days or youre bleeding more than usual, you may have menorrhagia. […] Heavy nosebleeds. […] Fatigue. […] The outlook varies depending on your or your childs unique situation. If your child has ITP, theyll probably get better within a few weeks or months without needing treatment. If you have persistent or chronic ITP, you may need medications and other treatments to manage your symptoms depending on how low your platelet count is, but youll always have the condition. Healthcare providers cant cure immune thrombocytopenia, but many people with chronic ITP live for decades with the condition.

• #1 Immune thrombocytopenia (ITP) | disease | symptoms | Sobi

  https://www.sobi.com/en/sobi-itp-immune-thrombocytopenia

  Common symptoms include fatigue, bruising that is unexpected or unusually severe, petechiae rash of tiny red or purple spots, purpura red or purple discoloured spots on the skin, prolonged or excessive bleeding from cuts, nosebleeds, bleeding gums, black blisters in the mouth, and for female patients, heavy periods. […] Fatigue is one of the main symptoms of ITP reported by patients. Various studies show that at least half of people living with ITP experience fatigue that can often interfere with everyday life. […] The fatigue experienced by people with autoimmune diseases such as ITP is different from the normal, temporary fatigue we all feel after a taxing activity such as concentrating for a long time or vigorous exercise, or after a poor night’s sleep. […] ITP usually develops gradually and often without a clear cause. When the condition lasts more than a year it is called chronic ITP.

• #1 Immune Thrombocytopenia – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK562282/

  Risk factors for major bleeding include a platelet count of less than 20,000/L, advanced age, and prior minor bleeding, with a higher incidence in the months following acute ITP diagnosis. […] The likelihood of developing ITP-associated complications correlates with bleeding risk, especially when the platelet count is less than 20,000/L. Most people with ITP have bruising and petechiae. Some individuals with ITP may experience mucosal bleeding, such as epistaxis or gum bleeding. Severe ITP may present with gastrointestinal tract bleeding, hematuria, or menorrhagia. […] The ICH risk in children with newly diagnosed ITP is about 0.5% and is slightly higher in children with chronic ITP, though still less than 1%. Most ICH cases occur at platelet levels less than 10,000/L. Concerning ICH symptoms in both children and adults include headache, persistent vomiting, altered mental status, seizures, focal neurological findings, and recent head trauma.

• #1 Immune thrombocytopenia: the patient’s perspective – Kruse – Annals of Blood

  https://aob.amegroups.org/article/view/6146/html

  Immune thrombocytopenia (ITP) is a rare heterogeneous autoimmune bleeding disorder that causes a lower than normal circulating platelet count resulting from impaired platelet production and accelerated platelet destruction. […] ITP leads to fatigue, challenges with daily activities, reduced physical functioning, anxiety, and depression. […] Aside from the constant risk for serious bleeding, patients experience both physical and emotional consequences living with their disease on a daily basis. […] Patients with ITP face many challenges. Actual disease burdens and perceived disease risks both influence the physical, emotional, and social health of patients and families with ITP impacting negatively their overall health-related quality of life (HRQoL). […] ITP patients experience a range of physical and emotional consequences as they monitor their platelet count, balance treatment side effects, and manage the fear of bleeding and frequent reality of relapse.

• #1 Immune Thrombocytopenia (ITP): Practice Essentials, Background, Pathophysiology

  https://emedicine.medscape.com/article/202158-overview

  ITP manifests as a bleeding tendency, easy bruising (purpura), or extravasation of blood from capillaries into skin and mucous membranes (petechiae). […] Although most cases of acute ITP, particularly in children, are mild and self-limited, intracranial hemorrhage may occur when the platelet count drops below 10 109/L ( 10 103/L); this occurs in 0.5-1% of children, and half of these cases are fatal. […] An initial impression of the severity of ITP is formed by examining the skin and mucous membranes, as follows: Widespread petechiae and ecchymoses, oozing from a venipuncture site, gingival bleeding, and hemorrhagic bullae indicate that the patient is at risk for a serious bleeding complication. […] Findings suggestive of intracranial hemorrhage include the following: Headache, blurred vision, somnolence, or loss of consciousness; Hypertension and bradycardia, which may be signs of increased intracranial pressure; On neurologic examination, any asymmetrical finding of recent onset; On fundoscopic examination, blurring of the optic disc margins or retinal hemorrhage.

• #1 Immune Thrombocytopenia – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK562282/

  Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by a low platelet count, purpura, and hemorrhagic episodes. […] Most children with ITP have spontaneous remission within a few weeks or months, rarely requiring splenectomy. However, spontaneous remission in adults is uncommon, necessitating splenectomy after a period of attempting medical therapy. […] Immune thrombocytopenia (ITP), formerly idiopathic thrombocytopenic purpura, is a condition arising from immunoglobulin G (IgG) autoantibodies sensitizing circulating platelets, manifesting as a low platelet count, purpura, and hemorrhagic episodes. […] Severe ITP, when platelet counts are below 20,000/L, warrants medical treatment. Immunosuppressive therapy is the cornerstone of management. […] Some patients with ITP are asymptomatic. When symptomatic, mucocutaneous bleeding is the most common manifestation, ranging from mild petechiae and epistaxis to severe and potentially life-threatening gastrointestinal, intracranial, or urinary tract hemorrhage.

• #1

  https://haematologica.org/article/view/7816

  This prospective observational cohort study aimed to explore the clinical features of incident immune thrombocytopenia in adults and predictors of outcome, while determining if a family history of autoimmune disorder is a risk factor for immune thrombocytopenia. […] 84% presented with bleeding symptoms. […] Immune thrombocytopenia in adults has been shown to progress to a chronic form in the majority of patients. […] ITP affects children and adults, with an incidence rate for the latter estimated between 2.8 and 3.9 per 100,000 person-years in Europe, and namely 2.9/100,000 in France. […] A recent retrospective study based on administrative registers reported that about two-thirds of adult ITP patients are likely to develop a chronic form of the disease. […] In our sample, only 37% of patients spontaneously recovered, i.e. without the need for disease-modifying treatment such as rituximab or splenectomy.

• #1 Immune Thrombocytopenic Purpura (ITP) Guide: Causes, Symptoms and Treatment Options

  https://www.drugs.com/health-guide/immune-thrombocytopenic-purpura-itp.html

  ITP does not usually cause symptoms as long as your platelet count remains above 50,000, which is typically the minimum needed to prevent abnormal bleeding. At lower platelet levels, ITP can cause different symptoms, depending on the type of ITP. […] Sometimes, the only symptom is the appearance of tiny purplish spots that show up on the lower legs. They are called petechiae. These are pinpoint size accumulations of blood under the skin caused by leaky small blood vessels. […] At very low platelet levels, ITP can cause different symptoms, depending on the type of ITP. […] Acute ITP — Symptoms usually begin abruptly. In children, the trigger can be a viral infection, with ITP symptoms appearing one to three weeks after the infection resolves. In adults, the trigger for acute ITP may not be obvious. The first sign of the illness may be a red or purple skin rash on the legs or abnormal bruising after only minor trauma. There also may be small areas of bleeding or „blood blisters” on the surface of the lips or gums, and frequent or severe nosebleeds. […] Persistent or Chronic ITP — A typical patient with persistent or chronic ITP is an adult woman who has had intermittent episodes of unexplained bruises, cuts that tend to heal slowly and ooze blood, prolonged bleeding after tooth extractions, and unusually long or heavy menstrual periods.

• #1 Immune Thrombocytopenia (ITP): Practice Essentials, Background, Pathophysiology

  https://emedicine.medscape.com/article/202158-overview

  More than 80% of children with untreated immune thrombocytopenia (ITP) have a spontaneous recovery with completely normal platelet counts in 2-8 weeks. Fatal bleeding occurs in 0.9% upon initial presentation. […] Approximately 60-90% of adults with ITP respond with an increased platelet count after treatment with prednisone or prednisone and IV RhIG or IVIG. Of those adults who do not maintain an increased platelet count and who require splenectomy, approximately two thirds have a sustained response and 10-15% have a partial response.

• #1 Immune Thrombocytopenia (ITP) | Boston Children’s Hospital

  https://www.childrenshospital.org/conditions/immune-thrombocytopenia-itp

  Immune thrombocytopenia (ITP) is an autoimmune disorder in which the body attacks its own platelets, blood cells that help control bleeding. […] Common symptoms of ITP include: Sudden appearance of bruises in an otherwise healthy child, Pinpoint-sized red dots on the skin (petechiae), Bloody noses, Bleeding from the gums, Heavy menstrual bleeding, Blood in the urine or stool, Fatigue. […] In most children, ITP goes away on its own within six to 12 months of diagnosis. ITP is more likely to resolve in children who are diagnosed at a young age with a very low platelet count. […] More than 80 percent of children with ITP recover on their own in six to twelve months regardless of whether they receive medication. After ITP resolves, it can occasionally occur again up to several years after the first episode, sometimes triggered by a viral infection.

• #1 Immune Thrombocytopenic Purpura (ITP)

  https://patient.info/allergies-blood-immune/blood-clotting-tests/immune-thrombocytopenia

  In immune thrombocytopenic purpura, antibodies are made against platelets. Once the antibodies have attached to platelets, the platelets do not work so well. […] Symptoms of ITP in children include bruising or a purple or red rash – purpura. There may be tiny red spots, or larger areas of bruising or rash. This usually appears over 1-2 days. […] The condition often occurs about 2-3 weeks after an infection (often a common viral infection). Occasionally, it follows immunisation. The symptoms often disappear over 6-8 weeks, and by six months in most cases. […] In adults, ITP comes on gradually and does not usually follow a viral illness. It is not really known what causes the disease. The symptoms may vary a lot. You may have no symptoms, purpura, mild bruising or bleeding, or severe bleeding.

• #1 Immune Thrombocytopenia (ITP) – Hematology and Oncology – Merck Manual Professional Edition

  https://www.merckmanuals.com/professional/hematology-and-oncology/thrombocytopenia-and-platelet-dysfunction/immune-thrombocytopenia-itp

  In children or adults with immune thrombocytopenia and life-threatening bleeding, rapid phagocytic blockade is attempted by giving IVIG 1 g/kg once a day for 1 to 2 days or, in Rh-positive patients, a single dose of IV anti-D immune globulin 75 mcg/kg. IV anti-D immunoglobulin is only effective in patients who have not had a splenectomy and may be associated with severe complications such as severe hemolysis and disseminated intravascular coagulation. IVIG treatment usually causes the platelet count to rise within 2 to 4 days, but the count remains high for only 2 to 4 weeks. […] Children typically recover spontaneously, even from severe thrombocytopenia, in several weeks to months. In adults, spontaneous remission occurs in under 10%. With completion of initial treatment, about one third of patients undergo remission. Up to 75% of patients improve within 5 years. However, many patients have mild and stable disease (ie, platelet counts 30,000/mcL) with minimal or no bleeding; they are often discovered by the automated platelet counting now routinely done with a complete blood count.

• #1 Immune thrombocytopenic purpura

  https://www.rch.org.au/clinicalguide/guideline_index/immune_thrombocytopenic_purpura/

  Immune thrombocytopenia (ITP) is an isolated low platelet count of 100 x109/L in a well child with an otherwise normal full blood evaluation (FBE) and film. […] The risk of intracranial haemorrhage in ITP is very low (1%). […] ITP is the most common cause of symptomatic thrombocytopenia in children. It is a diagnosis of exclusion as there is no specific laboratory test to confirm the diagnosis. […] Newly diagnosed ITP is within 3 months of diagnosis. ITP often resolves within 3 months, and resolves in 75% of children by 6 months. Chronic ITP is longer than 12 months. […] Sudden onset petechial rash or bruising. […] Bleeding symptoms can also include: epistaxis, gum or gastrointestinal bleeding, haematuria or menorrhagia. […] Very rarely intracranial haemorrhage (ICH): headache, nausea, vomiting, lethargy, irritability, decreased consciousness or neurological symptoms.

• #1 Immune Thrombocytopenic Purpura (ITP)

  https://patient.info/allergies-blood-immune/blood-clotting-tests/immune-thrombocytopenia

  Unlike ITP in children, most adults with ITP will continue to have a low number of platelets indefinitely. This is called chronic ITP. […] In adults, the outlook (prognosis) is variable depending on the severity of symptoms. Most people do not need any treatment. If treatment is needed, the response to treatment varies from person to person.

• #1 Chronic Immune Thrombocytopenia (ITP)

  https://www.webmd.com/a-to-z-guides/chronic-immune-thrombocytopenia

  Acute ITP symptoms often disappear after a few weeks. Chronic ITP symptoms last for a year or longer. The symptoms can continue for many years, or even for a lifetime. […] Chronic ITP can last for many years. Symptoms may come and go, but the condition is usually not life-threatening. You’ll need medications or other treatments long-term to keep your platelet count up and prevent serious bleeding. […] ITP can cause severe bleeding without treatment. The most serious complication is bleeding in the brain, which could be life-threatening.

• #1 What’s the Life Expectancy for Chronic ITP? | myITPcenter

  https://itp.myhealthteam.com/resources/whats-the-life-expectancy-for-chronic-itp

  The life expectancy of people with chronic immune thrombocytopenia (ITP) is about the same as that of people without the condition. […] In people with ITP, complications and comorbidities (unrelated health conditions) are usually the cause of death versus ITP itself. […] Generally speaking, most people with chronic ITP respond well to treatment and can live around as long as people without ITP. […] Studies show that most people with mild and moderate ITP have similar life expectancy to the general population (those without ITP or other health conditions). […] Overall, though, the average life span among people with ITP is shorter than that of the general population due to increased risk factors including high infection rates, hemorrhaging, heart disease, and blood cancer. […] For people with refractory ITP that’s resistant to treatment, the risk of death is higher.

• #1 Immune thrombocytopenic purpura (ITP) | Better Health Channel

  https://www.betterhealth.vic.gov.au/health/conditionsandtreatments/idiopathic-thrombocytopenic-purpura-itp

  In many cases of acute ITP, the platelet count will rise again within a few weeks and return to normal within a few months. […] Occasionally, a person who appears to have been cured of ITP will experience a relapse, perhaps months or even years after the initial episode. If this happens the person will need repeat treatment. The relapse may be triggered by a viral infection.

• #1

  https://haematologica.org/article/view/7816

  This confirms previous data suggesting that ITP is more likely to follow a chronic course in affected adults, compared to children in whom cure is achieved within several weeks in most patients. […] Our results confirm that sex and age are not risk factors for chronicity. […] Likewise, no association was found between bleeding symptoms at baseline and chronicity. […] The presence of a higher platelet count or the absence of severe bleeding at baseline was found to be associated with increased odds of chronicity at 12 months. […] A familial history of autoimmune disorder was found in 9 (8.3%) out of the 109 case-patients explored. […] Overall, having a first-degree relative with a history of autoimmune disorder was not associated with increased odds of developing ITP. […] The study confirms that ITP is more common in women than men, and is frequently associated with cutaneous bleeding, even if life-threatening bleeding is rare. […] Initial treatment is required in more than 80% of patients and only 37% of patients achieve cure at one year of follow up with no need for disease-modifying treatment, indicating that ITP is a chronic disease in adults with a less favorable outcome compared to children.

• #1 What’s the Life Expectancy for Chronic ITP? | myITPcenter

  https://itp.myhealthteam.com/resources/whats-the-life-expectancy-for-chronic-itp

  The cause of your ITP can also affect your prognosis. […] A 2001 study found that people with secondary ITP had a higher risk of death as compared to those with primary ITP. […] The right treatment plan can help prevent platelet destruction and relieve your chronic ITP symptoms. […] Health experts do know that they can help lower your risk of severe bleeding this is one of the main causes of death in people with chronic ITP. […] Chronic ITP isn’t usually a cause of death. Instead, other conditions or complications are more likely. […] One study from Denmark found that people with ITP were at a higher risk of dying from the following conditions compared to people in the general population: Infections, Blood cancers like leukemia or lymphoma, Hemorrhages or severe bleeding, Cardiovascular (heart and lung) conditions. […] Chronic ITP increases your risk of bleeding, so talk to your doctor about what over-the-counter medications are best for you to take.

• #1 Immune Thrombocytopenic Purpura | Cedars-Sinai

  https://www.cedars-sinai.org/health-library/diseases-and-conditions/i/immune-thrombocytopenic-purpura.html

  Immune thrombocytopenic purpura (ITP) is a blood disorder. With this disease, you have a lower amount of platelets than normal in your blood. Platelets are blood cell fragments that help with blood clotting. Having fewer platelets can cause easy bruising, bleeding gums, and internal bleeding. […] Symptoms may include: Bruising or purple areas on the skin. These bruises (called purpura) are caused by bleeding under the skin. When you have ITP, bruises may occur for no known reason. […] Because platelets help stop bleeding, ITP symptoms are linked to increased bleeding. Each persons symptoms may vary depending on how low their platelet count is. […] A normal platelet count is about 150,000 to 450,000 per microliter (L) of blood. With ITP, the platelet count is less than 100,000. By the time major bleeding occurs, you may have a platelet count of less than 10,000. The lower your platelet count, the greater your risk of bleeding. […] ITP symptoms may look like other health problems. Always see your healthcare provider for a diagnosis. […] ITP may happen suddenly and go away in about 6 months (acute). Or it may be ongoing (chronic) and last for years.

• #1 Immune thrombocytopenia: the patient’s perspective – Kruse – Annals of Blood

  https://aob.amegroups.org/article/view/6146/html

  Fatigue is the most common symptom reported by patients with ITP regardless of age. […] In many cases, it is the most severely debilitating symptom reported by patients living with ITP. […] A high incidence of fatigue is also seen among adult participants in the registry. […] Many patients have reported they have anxiety over their platelet counts, worsening disease, and even about the possibility they may die. […] Living with ITP means living with unpredictability and a fear of bleeding which negatively impacts the QoL of most ITP patients, particularly if severe or spontaneous bleeding events occur. […] Depression is often co-morbid with fatigue, and is frequently reported in ITP in both adults and children. […] The levels of anxiety, pain, and depression reported within the ITP registry participants exceeds what is reported in the general population. […] High levels of anxiety and depression could reflect the unpredictability of ITP and the acceptance that the diagnosis comes with a constant risk of bleeding among those living with it.

• #1 Signs & Symptoms of Immune Thrombocytopenia (ITP) | DOPTELET® (avatrombopag)

  https://doptelet.com/what-is-itp/itp-signs-and-symptoms/

  You may see small red or purple spots start to appear from broken blood vessels on areas like your upper arms or lower legs. […] You may experience bleeding from your gums and nose, have an unusually heavy menstrual flow, or notice cuts bleeding for longer periods of time. You may also see blood in your urine, vomit, or stool. When platelets are low, your doctor may tell you to limit physical activity. […] For patients with chronic ITP, the most common side effects are headache, fatigue, bruising, nosebleeds, upper respiratory tract infection, joint pain, bleeding gums, purple or red spots on your skin (petechiae), and runny nose.

• #1 What Is Immune Thrombocytopenia (ITP): Symptoms, Causes, Diagnosis, Treatment, and Prevention | Everyday Health

  https://www.everydayhealth.com/immune-thrombocytopenia/guide/

  People with ITP have a shortage of platelets, which are the blood cells responsible for normal clotting. […] Individuals with ITP are therefore susceptible to excessive bleeding and bruising. […] Symptoms may begin to appear when platelet levels are very low. According to the National Organization for Rare Disorders (NORD), symptoms of ITP can include: Bruising or purple spots on the skin that occur very easily or for no known reason, Small red dots that resemble a rash, Frequent nosebleeds, Bleeding from the gums, Unusually long or heavy menstrual bleeding, Hematoma, or a pooling of clotted or partially clotted blood under the skin. A hematoma can cause pain and swelling. Blood in urine, stool, or vomit. […] ITP can also affect mental and emotional health, as well as overall quality of life. Symptoms like unexplained bruising may lead to embarrassment and social isolation. This may also be accompanied by depression and anxiety. Additionally, intense fatigue affects at least half of all adults with ITP.

• #1 Living With Immune Thrombocytopenia | Understanding ITP

  https://www.understandingitp.com/hcp/en-us/patient-experience

  Low platelets are only one dimension of ITP. […] In a study, patients living with ITP reported significantly worse health-related quality of life (HRQOL) compared to the general US population. Their HRQOL was also lower than that of patients living with cancer and other serious chronic conditions. […] ITP can impact patient quality of life (QOL) in multiple ways, including: […] Fatigue is common and often severe in patients with ITP. […] Fatigue is one of the horrible issues for ITP. I’d say I’m mostly at 75 to 60 percent energy on normal days. […] Of the HCPs surveyed in I-WISh, reported hearing about fatigue at diagnosis and rated of that fatigue as severe. […] Heavy menstrual bleeding can have a major negative impact on patient QOL. […] Of the 975 female patients interviewed in the I-WISh survey, reported heavy menstrual bleeding at diagnosis, and of those said it was one of their most severe symptoms. […] TEs are also more common among patients with ITP. […] Patients with ITP face up to a ~2X higher risk of TEs compared to the general population.

• #1 Platelet Disorders – Immune Thrombocytopenia (ITP) | NHLBI, NIH

  https://www.nhlbi.nih.gov/health/immune-thrombocytopenia

  Immune thrombocytopenia (ITP) is a type of platelet disorder. In ITP, your blood does not clot as it should, because you have a low platelet count. […] ITP may not cause any symptoms. However, ITP can cause bleeding that is hard to stop. This bleeding can be inside your body, underneath your skin, or from your skin. […] Signs of bleeding may include: Petechiae, which are small, flat red spots under the skin caused by blood leaking from blood vessels; Purpura, which is bleeding in your skin that can cause red, purple, or brownish-yellow spots; Clotted or partially clotted blood under your skin (called a hematoma) that looks or feels like a lump; Nosebleeds or bleeding from your gums; Blood in your urine or stool; Heavy menstrual bleeding; Extreme tiredness. […] For most children and adults, ITP is not a serious condition. Acute ITP in children often goes away on its own within a few weeks or months and does not return.

• #2 Immune thrombocytopenia (ITP) | Sobi Pro

  https://pro.sobi.com/en-gb/therapeutic-areas/haematology/immune-thrombocytopenia-ITP

  Only nine or ten adults in every 100,000 have ITP, a rare autoimmune disease affecting platelet production and characterised by fatigue, bruising and bleeding. […] The symptoms of immune thrombocytopenia can be very different for different individuals. In general, the severity of symptoms will vary according to how far the platelet count is below the normal range. […] Common symptoms include fatigue, bruising that is unexpected or unusually severe, petechiae rash of tiny red or purple spots, purpura red or purple discoloured spots on the skin, prolonged or excessive bleeding from cuts, nosebleeds, bleeding gums, black blisters in the mouth, and for female patients, heavy periods. […] Fatigue is one of the main symptoms of ITP reported by patients. Various studies show that at least half of people living with ITP experience fatigue that can often interfere with everyday life.

• #2 Immune thrombocytopenia (ITP) | disease | symptoms | Sobi

  https://www.sobi.com/en/sobi-itp-immune-thrombocytopenia

  Common symptoms include fatigue, bruising that is unexpected or unusually severe, petechiae rash of tiny red or purple spots, purpura red or purple discoloured spots on the skin, prolonged or excessive bleeding from cuts, nosebleeds, bleeding gums, black blisters in the mouth, and for female patients, heavy periods. […] Fatigue is one of the main symptoms of ITP reported by patients. Various studies show that at least half of people living with ITP experience fatigue that can often interfere with everyday life. […] The fatigue experienced by people with autoimmune diseases such as ITP is different from the normal, temporary fatigue we all feel after a taxing activity such as concentrating for a long time or vigorous exercise, or after a poor night’s sleep. […] ITP usually develops gradually and often without a clear cause. When the condition lasts more than a year it is called chronic ITP.

• #2 Immune Thrombocytopenia – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK562282/

  Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by a low platelet count, purpura, and hemorrhagic episodes. […] Most children with ITP have spontaneous remission within a few weeks or months, rarely requiring splenectomy. However, spontaneous remission in adults is uncommon, necessitating splenectomy after a period of attempting medical therapy. […] Immune thrombocytopenia (ITP), formerly idiopathic thrombocytopenic purpura, is a condition arising from immunoglobulin G (IgG) autoantibodies sensitizing circulating platelets, manifesting as a low platelet count, purpura, and hemorrhagic episodes. […] Severe ITP, when platelet counts are below 20,000/L, warrants medical treatment. Immunosuppressive therapy is the cornerstone of management. […] Some patients with ITP are asymptomatic. When symptomatic, mucocutaneous bleeding is the most common manifestation, ranging from mild petechiae and epistaxis to severe and potentially life-threatening gastrointestinal, intracranial, or urinary tract hemorrhage.

• #2 Immune Thrombocytopenia (ITP): Symptoms, Diagnosis & Treatment

  https://my.clevelandclinic.org/health/diseases/5726-immune-thrombocytopenia

  Immune thrombocytopenia (ITP) is a rare blood disorder that affects how your blood clots. When your blood cant clot, you may bruise easily, bleed more than normal when youre hurt or start bleeding for no reason. Sometimes, ITP goes away without treatment. Other times, its a chronic condition, meaning treatment eases symptoms but doesnt cure it. […] Symptoms include petechia and purpura. Immune thrombocytopenia (ITP) may not cause symptoms. When it does, symptoms may include petechia (left) or purpura (right). […] You may not have any symptoms, but they can happen slowly or quickly if you do. Symptoms may include: […] Petechiae: This symptom appears as tiny red or purple dots on your lower legs that resemble a rash. […] Purpura: This is when petechiae join together, forming red, purple or brown spots on your skin. The spots are larger than petechiae but smaller than a bruise. This happens when small blood vessels under your skin leak blood.

• #2 Chronic Immune Thrombocytopenia (ITP)

  https://www.webmd.com/a-to-z-guides/chronic-immune-thrombocytopenia

  Immune thrombocytopenia (ITP) is a rare blood disorder. Your immune system mistakenly destroys platelets, cell fragments that help your blood clot after an injury. The lack of platelets can make you bruise or bleed more easily. […] A major (significant) drop in platelets can make you bruise or bleed more easily. Common bleeding symptoms from ITP include: Bruises that appear on your skin for no reason, Tiny reddish-purple spots called petechiae on your lower legs, from leaking blood vessels under the skin, Large red, purple, or brown spots called purpura. […] Many people have no symptoms in the early stages when ITP is mild. Once your platelet count drops very low, you may bruise or bleed more easily than usual. […] A low platelet count also causes symptoms like these: Bleeding gums, Nosebleeds that are hard to stop, Blood in your urine or poop, Heavy periods that last longer than seven days, Extreme tiredness.

• #2 ITP Symptoms and Signs: What to Look For

  https://www.verywellhealth.com/itp-symptoms-5184961

  Immune thrombocytopenia (ITP) is a disorder in which the immune system inappropriately sees platelets as foreign in the body and destroys them. Platelets are a type of blood cell made in the bone marrow with the job of helping the blood to clot, stop bleeding, and heal blood vessel walls. […] In ITP, platelets are destroyed, causing the total number of platelets in the blood to decrease. Decreased platelets can lead to bleeding or bruising. […] When platelet counts in the blood are low, excessive bruising may occur, as there are not enough platelets to quickly stop bleeding. […] These bruises are called purpura. Minor trauma, such as bumping the skin, may cause a bruise to develop. Some bruising may develop without any known injury or cause. […] Red spots that develop on the skin are called petechiae. These are tiny, pinpoint dots of bleeding under the skin. They typically appear in groups, may look like a rash, and are caused by broken blood vessels under the skin.

• #2 What’s the Life Expectancy for Chronic ITP? | myITPcenter

  https://itp.myhealthteam.com/resources/whats-the-life-expectancy-for-chronic-itp

  The cause of your ITP can also affect your prognosis. […] A 2001 study found that people with secondary ITP had a higher risk of death as compared to those with primary ITP. […] The right treatment plan can help prevent platelet destruction and relieve your chronic ITP symptoms. […] Health experts do know that they can help lower your risk of severe bleeding this is one of the main causes of death in people with chronic ITP. […] Chronic ITP isn’t usually a cause of death. Instead, other conditions or complications are more likely. […] One study from Denmark found that people with ITP were at a higher risk of dying from the following conditions compared to people in the general population: Infections, Blood cancers like leukemia or lymphoma, Hemorrhages or severe bleeding, Cardiovascular (heart and lung) conditions. […] Chronic ITP increases your risk of bleeding, so talk to your doctor about what over-the-counter medications are best for you to take.

• #2 Immune thrombocytopenic purpura (ITP) | Better Health Channel

  https://www.betterhealth.vic.gov.au/health/conditionsandtreatments/idiopathic-thrombocytopenic-purpura-itp

  Immune thrombocytopenic purpura (ITP) is a rare autoimmune disorder that causes you to have low platelet levels. […] A person with ITP may have a platelet count of 20 000 (20×109/L) or lower. […] In most people with mild ITP, there are no symptoms and they will feel perfectly well. However, if the platelet count drops very low, they may experience an increase in bruising or bleeding. These symptoms may include: skin that bruises very easily, a skin rash of small red dots (petechiae), which does not blanch (go pale) with pressure, bleeding from any area of the body, bleeding from the gums, frequent nosebleeds that take a long time to stop, internal bleeding, long or heavy menstrual periods. […] Fatigue is also a common symptom in ITP. The cause of this is poorly understood as platelets are not involved in maintaining energy levels.

• #2 ITP Symptoms: Bruising, Bleeding, and More

  https://www.healthline.com/health/understanding-itp/strange-symptoms-itp

  Petechiae […] Immune thrombocytopenia (ITP) affects how the blood clots and may result in various symptoms, such as unexplained bruises, frequent bleeding from the gums and nose, and fatigue. […] For many people, ITP doesn’t cause symptoms. When they do appear, platelet levels are often very low, which leads to excessive bleeding. This can result in symptoms like: small red bumps on the skin (petechiae) […] Unexplained bruises […] Sometimes frequent bruising is a symptom of ITP. Low levels of blood platelets can make it more difficult for your blood to clot, causing the skin to bruise even after a minimal injury. […] Bleeding from your gums […] Gum bleeding from ITP may occur during dental work, like routine teeth cleaning or other dental procedures. […] Frequent nosebleeds […] If you find yourself having many weekly nosebleeds despite being well and keeping your nose moist, you may need to talk with a healthcare professional to determine the cause and get treatment.

• #2 Immune thrombocytopenia (ITP) – Symptoms and causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/idiopathic-thrombocytopenic-purpura/symptoms-causes/syc-20352325

  Immune thrombocytopenia (ITP) is an illness that can lead to bruising and bleeding. Low levels of the cells that help blood clot, also known as platelets, most often cause the bleeding. […] Once known as idiopathic thrombocytopenic purpura, ITP can cause purple bruises. It also can cause tiny reddish-purple dots on the skin that look like a rash. […] Immune thrombocytopenia might not have symptoms. When symptoms occur, they might include: Easy bruising. Bleeding into the skin that looks like tiny reddish-purple spots, also known as petechiae. The spots mostly show up on the lower legs. They look like a rash. Bleeding into the skin that’s larger than petechiae, also known as purpura. Bleeding from the gums or nose. Blood in urine or stools. Really heavy menstrual flow. […] Make an appointment with your health care provider if you or your child has symptoms that worry you. Bleeding that won’t stop is a medical emergency. Seek help right away if you or your child has bleeding that the usual first aid efforts can’t control. These include applying pressure to the area. […] Rarely, immune thrombocytopenia causes bleeding into the brain. This can be fatal.

• #2 Immune Thrombocytopenic Purpura in Children | Cedars-Sinai

  https://www.cedars-sinai.org/health-library/diseases-and-conditions—pediatrics/i/immunethrombocytopenic-purpura-in-children.html

  Blood in urine or stool […] Heavy menstrual bleeding (period) that is unusual […] Vomiting with blood […] Bleeding with a head injury. This may be life-threatening in a child with ITP. […] Internal bleeding. If the platelet count is very low, there is a risk for internal bleeding, such as in the brain or the abdomen. […] The symptoms of ITP may look like other health problems. Always check with your child’s healthcare provider for a diagnosis. […] ITP is a blood disorder with decreased blood platelets. It may result in easy bruising, bleeding gums, and internal bleeding. […] The cause is usually unknown, but it may be an autoimmune disorder or follow a viral illness. It can also occur with certain medicines or vaccines. […] Treatment may not be needed. Observation alone is a very common approach. The most common treatments are immune globulin or corticosteroids.

• #2 Signs & Symptoms of Immune Thrombocytopenia (ITP) | DOPTELET® (avatrombopag)

  https://doptelet.com/what-is-itp/itp-signs-and-symptoms/

  Its important to understand the signs and symptoms of ITP. Knowing what to look for, and tracking any changes, can help you make informed treatment decisions with your doctor. […] ITP is known as a heterogeneous disease, which means you may experience different signs and symptoms than someone else with ITP. […] Most people with ITP have platelet counts under 100,000 per microliter, but those counts vary from person to person, and you may find your platelet counts are unpredictable at times. The lower your platelet count, the greater the risk of ITP symptoms. […] Here are some common signs and symptoms of ITP: […] You may feel exhausted and unable to keep up with everyday activities to the point where you may feel tired even after getting a full nights sleep. […] You may notice your skin start to bruise very easily, even spontaneously, from damaged blood vessels under the skin. Bruising may happen even if you dont remember injuring yourself.

• #2 Immune thrombocytopenia: the patient’s perspective – Kruse – Annals of Blood

  https://aob.amegroups.org/article/view/6146/html

  Fatigue is the most common symptom reported by patients with ITP regardless of age. […] In many cases, it is the most severely debilitating symptom reported by patients living with ITP. […] A high incidence of fatigue is also seen among adult participants in the registry. […] Many patients have reported they have anxiety over their platelet counts, worsening disease, and even about the possibility they may die. […] Living with ITP means living with unpredictability and a fear of bleeding which negatively impacts the QoL of most ITP patients, particularly if severe or spontaneous bleeding events occur. […] Depression is often co-morbid with fatigue, and is frequently reported in ITP in both adults and children. […] The levels of anxiety, pain, and depression reported within the ITP registry participants exceeds what is reported in the general population. […] High levels of anxiety and depression could reflect the unpredictability of ITP and the acceptance that the diagnosis comes with a constant risk of bleeding among those living with it.

• #2 Living With Immune Thrombocytopenia | Understanding ITP

  https://www.understandingitp.com/hcp/en-us/patient-experience

  Low platelets are only one dimension of ITP. […] In a study, patients living with ITP reported significantly worse health-related quality of life (HRQOL) compared to the general US population. Their HRQOL was also lower than that of patients living with cancer and other serious chronic conditions. […] ITP can impact patient quality of life (QOL) in multiple ways, including: […] Fatigue is common and often severe in patients with ITP. […] Fatigue is one of the horrible issues for ITP. I’d say I’m mostly at 75 to 60 percent energy on normal days. […] Of the HCPs surveyed in I-WISh, reported hearing about fatigue at diagnosis and rated of that fatigue as severe. […] Heavy menstrual bleeding can have a major negative impact on patient QOL. […] Of the 975 female patients interviewed in the I-WISh survey, reported heavy menstrual bleeding at diagnosis, and of those said it was one of their most severe symptoms. […] TEs are also more common among patients with ITP. […] Patients with ITP face up to a ~2X higher risk of TEs compared to the general population.

• #2 Immune Thrombocytopenia – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK562282/

  Risk factors for major bleeding include a platelet count of less than 20,000/L, advanced age, and prior minor bleeding, with a higher incidence in the months following acute ITP diagnosis. […] The likelihood of developing ITP-associated complications correlates with bleeding risk, especially when the platelet count is less than 20,000/L. Most people with ITP have bruising and petechiae. Some individuals with ITP may experience mucosal bleeding, such as epistaxis or gum bleeding. Severe ITP may present with gastrointestinal tract bleeding, hematuria, or menorrhagia. […] The ICH risk in children with newly diagnosed ITP is about 0.5% and is slightly higher in children with chronic ITP, though still less than 1%. Most ICH cases occur at platelet levels less than 10,000/L. Concerning ICH symptoms in both children and adults include headache, persistent vomiting, altered mental status, seizures, focal neurological findings, and recent head trauma.

• #2 Chronic Immune Thrombocytopenia (ITP)

  https://www.webmd.com/a-to-z-guides/chronic-immune-thrombocytopenia

  Acute ITP symptoms often disappear after a few weeks. Chronic ITP symptoms last for a year or longer. The symptoms can continue for many years, or even for a lifetime. […] Chronic ITP can last for many years. Symptoms may come and go, but the condition is usually not life-threatening. You’ll need medications or other treatments long-term to keep your platelet count up and prevent serious bleeding. […] ITP can cause severe bleeding without treatment. The most serious complication is bleeding in the brain, which could be life-threatening.

• #2 Immune thrombocytopenic purpura – Wikipedia

  https://en.wikipedia.org/wiki/Immune_thrombocytopenic_purpura

  In cases where platelet counts drop to extremely low levels (5,000 per L), serious and potentially fatal complications may arise. These complications include subarachnoid or intracerebral hemorrhage (bleeding inside the skull or brain), lower gastrointestinal bleeding, or other internal bleeding. A person with ITP with an extremely low platelet count is susceptible to internal bleeding resulting from blunt abdominal trauma, such as in a motor vehicle crash. These complications are more likely to occur when the platelet count is less than 20,000 per L. […] In general, patients with acute ITP will only rarely have life-threatening bleeding. Most patients ultimately have lower, but stable platelet counts, which are still hemostatic for the patient. Unlike children and adolescents, ITP is often chronic in adults, even after a splenectomy.

• #2 Immune thrombocytopenia – Symptoms, diagnosis and treatment | BMJ Best Practice US

  https://bestpractice.bmj.com/topics/en-us/138

  Immune thrombocytopenia (ITP) in children typically presents with a preceding viral illness and an abrupt onset. There is a female preponderance among adults, who may present with thrombocytopenia with or without bleeding. […] Petechiae occur primarily on the lower limbs, but can appear anywhere on the body (including mucosal membranes), particularly if thrombocytopenia is severe. Bruising is common. Mucosal bleeding may also occur in more severe cases. Intracranial bleeding is reported in approximately 0.5% of children and 1.5% of adults. […] Prognosis is good in children, with up to 80% achieving a spontaneous remission. Mortality is higher in older patients and in those unresponsive to several lines of treatment.

• #2 Symptoms of Immune Thrombocytopenia | Everyday Health

  https://www.everydayhealth.com/immune-thrombocytopenia/symptoms/

  Symptoms of Immune Thrombocytopenia, also called ITP, is a disorder of the blood in which there is a shortage of platelets, or blood cells that are responsible for normal clotting. As a result of this shortage, blood does not clot as it should. But when platelet levels are too low, bleeding can occur both internally and externally. Symptoms may begin to appear when platelet levels are very low. Symptoms of ITP can include: Bruising or purple spots on the skin that occur very easily or for no known reason. These bruises are called purpura and may also appear in the mouth. Small red dots that resemble a rash. These dots, called petechiae, are actually caused by bleeding underneath the skin as a result of damage to blood vessels or leaks in a capillary wall. Frequent nosebleeds that are difficult to stop. Bleeding from the gums. Unusually long menstrual cycle or heavy menstrual bleeding. Hematoma, or a pooling of clotted or partially clotted blood under the skin. A hematoma can cause pain and swelling. Blood in urine, stool, or vomit. ITP can cause any or all of these symptoms. According to the Platelet Disorder Support Association (PDSA), the excessive bleeding that comes with ITP can lead to anemia, a condition characterized by low levels of red blood cells. In people with anemia, there aren’t enough healthy red blood cells to carry adequate oxygen to the body’s tissues. This often results in extreme fatigue and low energy levels. Mental health issues such as depression and anxiety are also common in people with ITP. In rare cases, ITP can lead to a brain bleed, or intracranial hemorrhage. Symptoms of brain bleeds may include: Sudden numbness, weakness, or paralysis in the face, arm, or leg, especially if it is on one side of the body. Nausea. Vomiting. Headache. Dizziness. Confusion. Difficulty swallowing. Trouble seeing or loss of vision. Slurred speech. Loss of balance. Seizures. Sensitivity to light. Stiff neck. Trouble reading, writing, or understanding speech. Difficulty breathing. Loss of consciousness. An intracranial hemorrhage is a medical emergency and can be fatal.

• #2 Immune Thrombocytopenia | Conditions | UCSF Health

  https://www.ucsfhealth.org/conditions/immune-thrombocytopenia

  Immune thrombocytopenia (ITP), also known as immune or idiopathic thrombocytopenic purpura, is a blood disorder in which the immune system destroys platelets. As a result, people with ITP develop low platelet counts. This can cause red or purple dots on the skin, called petechiae, and problems with easy bruising, nosebleeds, blood blisters in the mouth or internal bleeding. […] The most common symptoms of ITP are petechiae (red or purple dots on the skin), bruising and bleeding. When ITP is severe and the platelet count is less than 10,000, patients will often notice petechiae and bruising with minimal contact. […] Bleeding can occur anywhere but is most typical in the nose, mouth and gut. Women often notice excessive menstrual bleeding. Rarely, but most dangerously, people with ITP can develop bleeding in the brain, which can be life-threatening.

• #2

  https://haematologica.org/article/view/7816

  This confirms previous data suggesting that ITP is more likely to follow a chronic course in affected adults, compared to children in whom cure is achieved within several weeks in most patients. […] Our results confirm that sex and age are not risk factors for chronicity. […] Likewise, no association was found between bleeding symptoms at baseline and chronicity. […] The presence of a higher platelet count or the absence of severe bleeding at baseline was found to be associated with increased odds of chronicity at 12 months. […] A familial history of autoimmune disorder was found in 9 (8.3%) out of the 109 case-patients explored. […] Overall, having a first-degree relative with a history of autoimmune disorder was not associated with increased odds of developing ITP. […] The study confirms that ITP is more common in women than men, and is frequently associated with cutaneous bleeding, even if life-threatening bleeding is rare. […] Initial treatment is required in more than 80% of patients and only 37% of patients achieve cure at one year of follow up with no need for disease-modifying treatment, indicating that ITP is a chronic disease in adults with a less favorable outcome compared to children.

• #2 Immune Thrombocytopenia (ITP): Practice Essentials, Background, Pathophysiology

  https://emedicine.medscape.com/article/202158-overview

  More than 80% of children with untreated immune thrombocytopenia (ITP) have a spontaneous recovery with completely normal platelet counts in 2-8 weeks. Fatal bleeding occurs in 0.9% upon initial presentation. […] Approximately 60-90% of adults with ITP respond with an increased platelet count after treatment with prednisone or prednisone and IV RhIG or IVIG. Of those adults who do not maintain an increased platelet count and who require splenectomy, approximately two thirds have a sustained response and 10-15% have a partial response.

• #2 Immune thrombocytopenic purpura (ITP) | Better Health Channel

  https://www.betterhealth.vic.gov.au/health/conditionsandtreatments/idiopathic-thrombocytopenic-purpura-itp

  In many cases of acute ITP, the platelet count will rise again within a few weeks and return to normal within a few months. […] Occasionally, a person who appears to have been cured of ITP will experience a relapse, perhaps months or even years after the initial episode. If this happens the person will need repeat treatment. The relapse may be triggered by a viral infection.

• #2 Immune thrombocytopenic purpura

  https://www.rch.org.au/clinicalguide/guideline_index/immune_thrombocytopenic_purpura/

  Immune thrombocytopenia (ITP) is an isolated low platelet count of 100 x109/L in a well child with an otherwise normal full blood evaluation (FBE) and film. […] The risk of intracranial haemorrhage in ITP is very low (1%). […] ITP is the most common cause of symptomatic thrombocytopenia in children. It is a diagnosis of exclusion as there is no specific laboratory test to confirm the diagnosis. […] Newly diagnosed ITP is within 3 months of diagnosis. ITP often resolves within 3 months, and resolves in 75% of children by 6 months. Chronic ITP is longer than 12 months. […] Sudden onset petechial rash or bruising. […] Bleeding symptoms can also include: epistaxis, gum or gastrointestinal bleeding, haematuria or menorrhagia. […] Very rarely intracranial haemorrhage (ICH): headache, nausea, vomiting, lethargy, irritability, decreased consciousness or neurological symptoms.

• #2 What’s the Life Expectancy for Chronic ITP? | myITPcenter

  https://itp.myhealthteam.com/resources/whats-the-life-expectancy-for-chronic-itp

  The life expectancy of people with chronic immune thrombocytopenia (ITP) is about the same as that of people without the condition. […] In people with ITP, complications and comorbidities (unrelated health conditions) are usually the cause of death versus ITP itself. […] Generally speaking, most people with chronic ITP respond well to treatment and can live around as long as people without ITP. […] Studies show that most people with mild and moderate ITP have similar life expectancy to the general population (those without ITP or other health conditions). […] Overall, though, the average life span among people with ITP is shorter than that of the general population due to increased risk factors including high infection rates, hemorrhaging, heart disease, and blood cancer. […] For people with refractory ITP that’s resistant to treatment, the risk of death is higher.

• #2 Norfolk and Norwich University Hospitals NHS Foundation Trust » Immune thrombocytopenia

  https://www.nnuh.nhs.uk/departments/haematology-department/non-malignant-haematology/immune-thrombocytopenia/

  If the platelet count is in the range 50-100 x 10^9/l there is usually no bleeding or bruising. If the platelet count falls below 50 x 10^9/l, some bruising may occur, and below 20 x 10^9/l, bruising and petechiae (pinpoint blood spots under the skin) are more likely. […] The most serious bleeding tends to occur in patients with a platelet count <10 x 10^9/l. However, with ITP most patients with platelets less than 10 x 10^9/l still have no major bleeding problems. [...] As with any medical condition, ITP may affect your quality of life. For example, about a third of those with ITP report fatigue symptoms. You may be worried about how bleeding might affect work and social activities. For most people, the impact of ITP on their quality of life seems to reduce after the first year, and in those with a good response to treatment.

• #2 Norfolk and Norwich University Hospitals NHS Foundation Trust » Immune thrombocytopenia

  https://www.nnuh.nhs.uk/departments/haematology-department/non-malignant-haematology/immune-thrombocytopenia/

  A purple rash called purpura (often on the lower legs) which does not fade when you press it may be a sign of a low platelet count. […] If you have a prolonged episode of gum bleeding (over 30 minutes) or nose bleeds that will not stop despite pinching the nose, contact the hospital. […] If you vomit blood or have blood in the faeces or black sticky stools or other major bleeding you may need urgent medical help; please contact the haematology department or attend the Emergency Department of the nearest hospital. […] Also contact the hospital if you develop a severe headache when you have low platelets. Bleeding into the brain (intra-cranial bleeding) is a very rare but serious complication of ITP.

• #2 Immune thrombocytopenia (ITP) | Sobi Pro

  https://pro.sobi.com/en-gb/therapeutic-areas/haematology/immune-thrombocytopenia-ITP

  The fatigue experienced by people with autoimmune diseases such as ITP is different from the normal, temporary fatigue we all feel after a taxing activity such as concentrating for a long time or vigorous exercise, or after a poor night’s sleep. […] People living with ITP may worry about how bleeding could affect their work and social activities.

• #2 Platelet Disorders – Immune Thrombocytopenia (ITP) | NHLBI, NIH

  https://www.nhlbi.nih.gov/health/immune-thrombocytopenia

  Chronic ITP varies from person to person and can last for many years. Even people who have serious types of chronic ITP can live for decades. Most people who have chronic ITP can stop treatment at some point and maintain a safe platelet count. […] Without proper treatment, ITP can cause serious bleeding and pregnancy complications.

• #2 Immune Thrombocytopenia (ITP)

  https://www.pch.health.wa.gov.au/For-health-professionals/Referrals-to-PCH/Prereferral-guidelines/Immune-Thrombocytopenia

  Immune Thrombocytopenia (ITP) is a condition of isolated thrombocytopenia caused by immune mediated destruction of platelets typically presenting in children aged 2 to 10 years of age. […] Patients typically present with cutaneous signs (petechiae and bruising) and less commonly mucosal bleeding (haematuria or epistaxis). Intracranial haemorrhage is a rare, but serious complication of ITP associated with significant mortality and morbidity. […] Majority of newly diagnosed (3 months) ITP is self-limiting, with platelets spontaneously normalising within six months. However approximately 20% of patients may develop chronic (6 months) ITP and require ongoing haematology follow up.

• #2 Idiopathic Thrombocytopenic Purpura (ITP): Symptoms and Diagnosis

  https://www.healthline.com/health/idiopathic-thrombocytopenic-purpura-itp

  For most people with ITP, the condition isn’t serious or life threatening. […] For example, acute ITP in children often resolves within 6 months or less without treatment. Chronic ITP, though, can last for many years. Still, people can live for many decades with the disease, even those with severe cases. […] Many people with ITP are able to manage their condition safely without any long-term complications or a decreased life span.

• #2 What is Immune Thrombocytopenia (ITP) | Nplate® (romiplostim)

  https://www.nplate.com/itp

  Immune thrombocytopenia, previously called idiopathic thrombocytopenic purpura, is an autoimmune disease that lowers the body’s platelet count, so you don’t have enough platelets in your blood. Its cause is unknown and there is no cure. […] Because of the peaks and valleys of platelet counts, living with ITP can be unpredictable and feel like a roller coaster. […] Some people find out they have ITP because they have symptoms, while others show no symptoms. […] Small red dots on the skin caused by broken blood vessels (petechiae) […] Purple spots on the skin (purpura) […] Bruising on the arms and legs resulting from seemingly minor bumps (ecchymosis) […] Frequent or heavy nosebleeds (epistaxis) […] Heavy bleeding during menstruation (menorrhagia) […] Bleeding from the gums (gingival bleeding) […] Blood in the urine (hematuria). […] If a person with ITP has very low platelet counts, it is possible to have internal bleeding or, in rare cases, bleeding in the brain. Severe bleeding is rare in ITP. […] It’s important to tell your doctor about any symptoms you’re experiencing.

• #3 ITP Symptoms: Bruising, Bleeding, and More

  https://www.healthline.com/health/understanding-itp/strange-symptoms-itp

  Heavier-than-normal periods […] Low platelet counts from ITP can affect your menstrual cycle, making periods heavier than usual. […] Blood in your urine or stools […] The low platelet count associated with ITP can also cause bleeding in your urine or stools. […] Hematoma […] ITP can also cause small lumps underneath the skin. These are called hematomas. […] Excessive fatigue […] Moderate bleeding can lead to anemia. You might feel overly fatigued as a result. […] Low mental energy […] Excessive fatigue can affect more than your physical energy. It can affect your mental energy, too. […] It’s important to know about the symptoms of ITP. That way, if you do experience any of them, you’ll be able to seek medical attention to help keep your symptoms from getting worse.

• #3 Immune thrombocytopenia: the patient’s perspective – Kruse – Annals of Blood

  https://aob.amegroups.org/article/view/6146/html

  Immune thrombocytopenia (ITP) is a rare heterogeneous autoimmune bleeding disorder that causes a lower than normal circulating platelet count resulting from impaired platelet production and accelerated platelet destruction. […] ITP leads to fatigue, challenges with daily activities, reduced physical functioning, anxiety, and depression. […] Aside from the constant risk for serious bleeding, patients experience both physical and emotional consequences living with their disease on a daily basis. […] Patients with ITP face many challenges. Actual disease burdens and perceived disease risks both influence the physical, emotional, and social health of patients and families with ITP impacting negatively their overall health-related quality of life (HRQoL). […] ITP patients experience a range of physical and emotional consequences as they monitor their platelet count, balance treatment side effects, and manage the fear of bleeding and frequent reality of relapse.

• #3 What’s the Life Expectancy for Chronic ITP? | myITPcenter

  https://itp.myhealthteam.com/resources/whats-the-life-expectancy-for-chronic-itp

  The cause of your ITP can also affect your prognosis. […] A 2001 study found that people with secondary ITP had a higher risk of death as compared to those with primary ITP. […] The right treatment plan can help prevent platelet destruction and relieve your chronic ITP symptoms. […] Health experts do know that they can help lower your risk of severe bleeding this is one of the main causes of death in people with chronic ITP. […] Chronic ITP isn’t usually a cause of death. Instead, other conditions or complications are more likely. […] One study from Denmark found that people with ITP were at a higher risk of dying from the following conditions compared to people in the general population: Infections, Blood cancers like leukemia or lymphoma, Hemorrhages or severe bleeding, Cardiovascular (heart and lung) conditions. […] Chronic ITP increases your risk of bleeding, so talk to your doctor about what over-the-counter medications are best for you to take.

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