Guzy i obrzęki jąder
Epidemiologia

Guzy i obrzęki jąder są powszechnymi objawami u mężczyzn i osób z jądrami, z których większość ma charakter łagodny. Rak jądra, choć stanowi jedynie 0,5% wszystkich nowotworów, jest najczęstszym nowotworem litym u mężczyzn w wieku 15-35 lat, z roczną zachorowalnością wynoszącą 6,0 na 100 000 mężczyzn (dane SEER 2016-2020). Ryzyko zachorowania w ciągu życia wynosi około 1 na 250, a śmiertelność jest niska (1 na 5000). Występują trzy szczyty zachorowań: niemowlęctwo do 4 roku życia (potworniaki, guzy pęcherzyka żółtkowego), wiek 25-40 lat (nasieniaki i nienasieniaki) oraz powyżej 60 roku życia (guzy spermatocytarne). Czynniki ryzyka obejmują neoplazję zarodkową in situ (GCNIS), wnętrostwo (4-6-krotny wzrost ryzyka), historię rodzinną oraz osobistą raka jądra (12-krotny wzrost ryzyka nowotworu w drugim jądrze). Diagnostyka opiera się na badaniu fizykalnym, USG moszny, markerach nowotworowych (AFP, hCG, LDH) oraz badaniach obrazowych (RTG klatki piersiowej, TK, MRI). Nadzór (surveillance) jest zalecany w stadium 0 i niektórych przypadkach stadium I, umożliwiając monitorowanie bez natychmiastowego leczenia.

Epidemiologia guzów i obrzęków jąder

Guzy i obrzęki jąder są stosunkowo częstymi zjawiskami u mężczyzn, chłopców i wszystkich osób posiadających jądra. Większość z nich ma charakter łagodny i nie wymaga leczenia. Jednakże, niektóre guzy mogą wskazywać na poważniejsze schorzenia, w tym na raka jądra, który jest najczęstszym nowotworem litym u młodych mężczyzn w wieku 15-35 lat.123

Występowanie raka jąder

Rak jądra jest stosunkowo rzadkim nowotworem, stanowiącym zaledwie 0,5% wszystkich nowych przypadków nowotworów w Stanach Zjednoczonych. Szacuje się, że w 2023 roku w USA zdiagnozowano około 9190 nowych przypadków raka jądra. Ryzyko zachorowania w ciągu życia wynosi około 1 na 250, a ryzyko zgonu jest bardzo niskie, około 1 na 5000.45

Według danych SEER (Surveillance, Epidemiology, and End Results) z 18 obszarów geograficznych, skorygowana względem wieku roczna zachorowalność na raka jądra w latach 2016-2020 wynosiła 6,0 na 100 000 mężczyzn. Jednak zachorowalność znacznie różni się w zależności od rasy/pochodzenia etnicznego.6

Badania dotyczące raka jądra w wybranych populacjach na świecie w latach 1973-2007 wykazały wyraźną tendencję wzrostową zachorowalności w większości badanych populacji. W ostatnich latach wskaźniki zachorowań ustabilizowały się w niektórych regionach, a nawet spadły w kilku przypadkach.7

Dystrybucja geograficzna i demograficzna

Rak jądra ma najwyższą częstość występowania w USA i Europie, a jest rzadki w Azji i Afryce. Światowa zapadalność podwoiła się od lat 60., z najwyższymi wskaźnikami występowania w Skandynawii, Niemczech i Nowej Zelandii.8

Ryzyko zachorowania na raka jądra u białych mężczyzn jest około 45 razy wyższe niż u czarnoskórych mężczyzn i ponad 3 razy wyższe niż u Azjatów mieszkających w Ameryce. Ryzyko zachorowania u Latynosów i rdzennych Amerykanów znajduje się pomiędzy ryzykiem dla białych i azjatyckich mężczyzn. Przyczyna tych różnic pozostaje nieznana.9

W Wielkiej Brytanii rocznie diagnozuje się około 2000 przypadków raka jądra. W ciągu życia ryzyko zachorowania wynosi około 1 na 200 (0,5%). Jest to 16. najczęściej występujący nowotwór u mężczyzn, stanowiący mniej niż 1% zgonów z powodu nowotworów u mężczyzn (około 60 mężczyzn zmarło w 2012 roku).10

Trendy wiekowe

Chociaż rak jądra jest najczęstszy wśród mężczyzn w wieku 15-40 lat, występuje w trzech szczytach wiekowych:11

  • W niemowlęctwie do 4 roku życia jako potworniaki i guzy pęcherzyka żółtkowego
  • W wieku 25-40 lat jako poporodowe nasieniaki i nienasieniaki
  • Od 60 roku życia jako guzy spermatocytarne

11

Nowotwory zarodkowe jądra są najczęstszym nowotworem złośliwym u młodych mężczyzn w wieku od 15 do 35 lat. Rak jądra może jednak wystąpić w każdym wieku, a w bardzo rzadkich przypadkach może pojawić się przed okresem dojrzewania. Tylko 8% przypadków występuje po 55 roku życia.1213

Czynniki ryzyka

Czynniki ryzyka rozwoju raka jądra obejmują:14

  • Neoplazja zarodkowa in situ (GCNIS) – prekursor większości nowotworów zarodkowych jąder
  • Wnętrostwo (niezstąpienie jądra) – zwiększa ryzyko 4-6 krotnie, ale spada do 2-3 krotnego jeśli orchidopeksja zostanie wykonana przed okresem dojrzewania
  • Historia rodzinna – mężczyźni z krewnymi pierwszego stopnia chorymi na nowotwór zarodkowy jądra mają zwiększone ryzyko zachorowania
  • Historia osobista – mężczyźni z historią raka jądra mają 12-krotnie zwiększone ryzyko rozwoju nowotworu zarodkowego w przeciwległym jądrze, ale 15-letnia skumulowana zachorowalność wynosi tylko 2%

1516

Nadzór i badania przesiewowe w guzach i obrzękach jąder

Nadzór i wczesne wykrywanie odgrywają kluczową rolę w diagnostyce i leczeniu guzów jąder, szczególnie w przypadku raka jądra. Regularne badania lekarskie i samokontrola mogą przyczynić się do wczesnego wykrycia zmian, co zwiększa szanse na skuteczne leczenie.1718

Wytyczne dotyczące badań przesiewowych

Amerykańskie Towarzystwo Nowotworowe (ACS) zaleca mężczyznom, aby byli świadomi raka jądra i natychmiast konsultowali się z lekarzem, jeśli wykryją guzek w jądrze. ACS nie ma jednak rekomendacji dotyczących regularnych samobadań jąder dla wszystkich mężczyzn, ponieważ nie przeprowadzono wystarczających badań, aby stwierdzić, czy zmniejszają one śmiertelność z powodu tego nowotworu.19

Amerykańska Grupa Zadaniowa ds. Usług Prewencyjnych (USPSTF) zaleca przeciwko badaniom przesiewowym w kierunku raka jądra u bezobjawowych nastolatków i dorosłych mężczyzn z przeciętnym ryzykiem ze względu na niską częstość występowania choroby i wysokie wskaźniki wyleczenia nawet w zaawansowanych przypadkach.20

Metody nadzoru i monitorowania

Nadzór (surveillance) to sposób obserwacji zmian poprzez regularne badania kontrolne. Obejmują one:21

21

Badania obrazowe rozpoczynają się od USG moszny, mogą również obejmować zdjęcia rentgenowskie klatki piersiowej lub tomografię komputerową. Większość mężczyzn może być również badana pod kątem objawów niskiego poziomu testosteronu.22

Nadzór jest zalecany dla pacjentów z rakiem jądra w stadium 0 i niektórych przypadkach stadium I. W przypadkach, gdy nowotwór nie rozprzestrzenił się poza jądro, nadzór zamiast natychmiastowego leczenia może być preferowaną opcją, zwłaszcza w przypadku nowotworów niskiego ryzyka we wczesnym stadium.2324

Badania w diagnostyce guzów jąder

Większość guzków jąder można zdiagnozować podczas badania fizykalnego. Jednak lekarz może zlecić dodatkowe badania, aby potwierdzić diagnozę:25

  • USG moszny – pomaga określić, czy masa jest wewnątrz- czy zewnątrzjądrowa
  • Badania krwi – mogą wykazać obecność markerów nowotworowych, takich jak alfa-fetoproteina (AFP), ludzka gonadotropina kosmówkowa (hCG) i dehydrogenaza mleczanowa (LDH)
  • Biopsja – w niektórych przypadkach lekarz może zasugerować biopsję w celu sprawdzenia obecności raka jądra
  • Badania obrazowe – MRI lub CT mogą być używane do oceny rozprzestrzeniania się nowotworu do innych części ciała

2627

Obserwacja po leczeniu

Po zakończeniu leczenia raka jądra pacjent wymaga regularnych badań kontrolnych, aby upewnić się, że nowotwór nie powrócił. Nadzór po leczeniu ma na celu wczesne wykrycie nawrotów, co zwiększa szanse na skuteczne leczenie.2829

Długoterminowe badania kliniczne są bardzo ważne, ponieważ mężczyźni, którzy przebyli raka jądra, mają zwiększone ryzyko rozwoju nowotworu w drugim jądrze. Regularne badania kontrolne obejmują badanie fizykalne, testy markerów nowotworowych i badania obrazowe.30

Wyzwania w nadzorze epidemiologicznym guzów i obrzęków jąder

Nadzór epidemiologiczny guzów i obrzęków jąder stwarza szereg wyzwań, które wpływają na dokładność danych i możliwość wczesnego wykrywania zmian złośliwych.31

Trudności diagnostyczne

Jednym z głównych wyzwań jest rozróżnienie między łagodnymi a złośliwymi zmianami jąder. W badaniu brytyjskim, spośród 845 pacjentów skierowanych z powodu guzów lub bólu jąder, tylko 33 (4%) zdiagnozowano jako rak jądra.32

Obecne wytyczne NICE (National Institute for Health and Care Excellence) dotyczące raka jądra zalecają pilne skierowanie do specjalisty w przypadku mężczyzn z bezbolesnym powiększeniem lub zmianą kształtu lub struktury jądra. Większość objawów powiększenia lub obrzęku jąder wiąże się z ryzykiem wystąpienia raka na poziomie około 3%, co potwierdza zalecenie NICE dotyczące pilnego skierowania.3334

Guzek jądra i obrzęk jądra są silnie związane z rakiem w grupie wiekowej 50 lat, z wartościami pozytywnej wartości predykcyjnej (PPV) odpowiednio 2,5% i 2,3%, czyli wartościami tuż poniżej progu 3% dla pilnego skierowania.35

Czynniki wpływające na nadzór

Czynniki środowiskowe są uważane za instrumentalne w określaniu ryzyka wystąpienia nowotworów jąder. Jednak dowody epidemiologiczne nie potwierdzają konsekwentnie żadnego konkretnego czynnika ryzyka.36

Istnieją różnice w częstości występowania i rokowaniu raka jądra w zależności od rasy/pochodzenia etnicznego. Częstość występowania raka jądra jest pięciokrotnie wyższa u białych niż u Afroamerykanów, jednak Afroamerykanie mają tendencję do prezentowania choroby wyższego stopnia i mają znacznie gorsze rokowanie niż biali.37

Skuteczność systemów nadzoru

Mimo wyzwań, nadzór epidemiologiczny przyczynia się do poprawy wskaźników przeżywalności w raku jądra. W Europie Zachodniej pięcioletnia przeżywalność w przypadku raka jądra wynosi około 95%.38

Całkowity wskaźnik przeżywalności w przypadku raka jądra jest dość wysoki, przy czym ponad 95% mężczyzn zdiagnozowanych z rakiem jądra przeżywa co najmniej pięć lat po wstępnej diagnozie, a wielu żyje przez dziesiątki lat po leczeniu.39

Nastąpiła migracja stadiów nowotworu zarodkowego jądra, prawdopodobnie z powodu zwiększonej świadomości i wcześniejszej diagnozy. W latach 1973-2014 odsetek guzów diagnozowanych w stadium lokalnym wzrósł z 55% do 68% w Stanach Zjednoczonych. Obecnie mniej niż 15% mężczyzn zgłasza się z chorobą w stadium III (do płuc, narządów wewnętrznych lub pozaregionalnych węzłów chłonnych).40

Przeszłość i przyszłość nadzoru epidemiologicznego guzów jąder

Nadzór epidemiologiczny nad guzami i obrzękami jąder przeszedł znaczącą ewolucję na przestrzeni ostatnich dekad, a dane wskazują na zmieniające się wzorce zachorowalności i podejście do diagnostyki.41

Historyczne trendy

W Stanach Zjednoczonych częstość występowania raka jądra wzrosła o 100% w latach 1988-2001. Diagnozy nasieniaków wzrosły o 124% w tym okresie, a diagnozy nienasieniaków wzrosły o 64%. Nie zaobserwowano istotnego wzrostu częstości występowania choroby we wczesnym stadium w stosunku do wszystkich diagnoz w tej populacji, co wskazuje, że wzrost nie był spowodowany bardziej rozpowszechnionymi badaniami przesiewowymi lub wcześniejszym wykrywaniem.42

Na świecie, badania raka jądra w wybranych populacjach z lat 1973-2007 wykazały wyraźną tendencję wzrostową w większości badanych populacji. W ostatnich latach wskaźniki ustabilizowały się jednak w niektórych obszarach, a nawet spadły w kilku.43

Nowe metody nadzoru

Aktywny nadzór (active surveillance) staje się coraz ważniejszym elementem podejścia do wczesnego stadium raka jądra. Priorytetem dla pacjentów z chorobą w niskim stadium jest ograniczenie obciążenia terapii i toksyczności związanej z leczeniem bez kompromisów w zakresie kontroli nowotworu.44

Dla pacjentów z chorobą klinicznie ograniczoną do jądra, nadzór przyjął coraz większą rolę. W niektórych przypadkach, szczególnie dla nowotworów niskiego ryzyka we wczesnym stadium, lekarze mogą zalecać „czujne oczekiwanie” (watchful waiting) lub nadzór zamiast natychmiastowego leczenia.45

Przyszłe kierunki

Szacuje się, że w 2024 roku w Stanach Zjednoczonych zostanie zdiagnozowanych 9760 nowych przypadków raka jądra, a 500 osób umrze z powodu tej choroby. To podkreśla ciągłą potrzebę skutecznego nadzoru i wczesnego wykrywania.46

Miesiąc Świadomości Raka Jądra, obchodzony corocznie w kwietniu, ma na celu zwiększenie świadomości na temat raka jądra oraz promowanie edukacji, profilaktyki i wczesnego wykrywania tej choroby.47

Poprawa technik diagnostycznych, takich jak bardziej czułe badania obrazowe i dokładniejsze markery biologiczne, może potencjalnie poprawić wczesne wykrywanie i nadzór nad guzami jąder w przyszłości.48

Implikacje dla zdrowia publicznego

Guzy i obrzęki jąder, szczególnie te związane z rakiem jądra, mają istotne implikacje dla zdrowia publicznego, szczególnie biorąc pod uwagę, że dotykają głównie młodych, aktywnych zawodowo mężczyzn.49

Edukacja i świadomość

Regularne samobadanie jest szybkim i bezbolesnym sposobem na monitorowanie zdrowia jąder i wykrywanie wszelkich nietypowych zmian. Zaleca się obserwację i badanie jąder pod kątem guzków, obrzęków lub czegokolwiek, co nie wygląda normalnie.50

Mężczyźni powinni natychmiast skonsultować się z lekarzem, jeśli zauważą:51

  • Guzek w jądrach
  • Opuchnięte jądra
  • Zmianę kształtu jąder
  • Zmianę w odczuwaniu jąder
  • Jedno jądro, które stało się większe od drugiego
  • Ból lub dyskomfort w jądrach, który nie ustępuje

51

Obciążenie systemów opieki zdrowotnej

W 2002 roku zapalenie najądrza lub jąder stanowiło 1 na 144 wizyty ambulatoryjne (0,69%) u mężczyzn w wieku od 18 do 50 lat. W Stanach Zjednoczonych odnotowuje się około 600 000 przypadków zapalenia najądrza rocznie, z czego większość występuje u mężczyzn w wieku od 18 do 35 lat.52

Zapalenie najądrza jest częstsze niż zapalenie jąder. W jednym badaniu ambulatoryjnym zapalenie jąder wystąpiło u 58% mężczyzn ze zdiagnozowanym zapaleniem najądrza. Izolowane zapalenie jąder jest rzadkie i zwykle związane z zakażeniem świnką u chłopców w wieku przedpokwitaniowym (13 lat lub młodszych).53

Strategie prewencyjne

Chociaż nie można zapobiec rakowi jądra, wczesne wykrycie może znacznie poprawić rokowanie. Regularne samobadania i rutynowe badania lekarskie mogą pomóc wykryć raka jądra wcześnie, gdy jest najbardziej podatny na leczenie i może zwiększyć szanse na pomyślny wynik.54

Świadomość objawów raka jądra i innych schorzeń jąder jest kluczowa dla wczesnego zgłaszania się po pomoc medyczną. Do najczęstszych objawów guzów jąder należą:55

  • Powiększenie lub obrzęk jądra (często pierwsza oznaka)
  • Obrzęk zwykle dotyka jednej strony i rzadko obejmuje obie strony
  • Chociaż początkowy obrzęk nie jest bolesny, około jedna trzecia osób z rakiem jądra odczuwa tępy ból
  • Niektóre osoby mogą odczuwać uczucie ciężkości w mosznie lub dolnej części brzucha

5556

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Wybierz kolejny rozdział z menu poniżej, aby otworzyć nową podstronę kompedium wiedzy i uzyskać szczegółowe informację o leku, substancji lub chorobie.

  1. 09.04.2026
  2. www.leksykon.com.pl

Materiały źródłowe

  • #1 Testicular lumps and swellings | NHS inform
    https://www.nhsinform.scot/illnesses-and-conditions/sexual-and-reproductive/testicular-lumps-and-swellings/
    Lumps and swellings in the testicles (balls) are relatively common in boys, men and anyone with testicles. […] Speak to your GP practice if you have: a lump in your testicles, swollen testicles, a change in the shape of your testicles, a change in the way your testicles feel, 1 testicle that has become bigger than the other, aching or discomfort in your testicles that does not go away. […] The vast majority of testicular lumps and swellings are caused by non-cancerous (benign) conditions. Most of these may not need treatment. […] If you have been diagnosed with testicular cancer, you will be cared for by a team of clinicians who will help decide the best treatment for you. Surgery to remove the affected testicle will be recommended in most cases and this may sometimes be followed by a course of chemotherapy or radiotherapy.
  • #2 Scrotal Masses | AAFP
    https://www.aafp.org/pubs/afp/issues/2022/0800/scrotal-masses.html
    Scrotal and testicular masses can be broadly categorized into painful conditions, which include testicular torsion, torsion of the testicular appendage, and epididymitis, and painless conditions, which include hydrocele, varicocele, and testicular cancer. […] Testicular cancer is the most common solid tumor diagnosed in men between 15 and 34 years of age, and usually presents as a firm, unilateral nodule that is often but not necessarily painless. […] The U.S. Preventive Services Task Force recommends against screening for testicular cancer in asymptomatic average-risk adolescents and adult men because of the low prevalence of the disease and the high cure rates even in advanced cases. […] A varicocele is abnormal dilation of the pampiniform plexus, either caused by incompetence of the gonadal vein valves or external compression of the gonadal vein.
  • #3 How Can I Tell If I Have Testicular Cancer? – Scripps Health
    https://www.scripps.org/news_items/7529-how-to-tell-if-you-have-testicular-cancer
    Testicular cancer is a rare type of cancer, making up less than 1% of all cancers in men. But unlike most cancers, testicular cancer tends to develop at a younger age. It is the most common cancer in men 15 to 35. […] The American Cancer Society estimates 9,760 new cases of testicular cancer will be diagnosed and 500 people will die from the disease in 2024. […] The most common sign of testicular cancer is a lump or swelling in one of the testicles. This lump may be painless or may cause discomfort. […] Not all lumps in the testicles are cancer. Other conditions and health issues can cause the same symptoms, such as an injury or an infection. Still, its crucial to have any lumps or swelling checked by a doctor to rule out testicular cancer. […] Patients with testicular masses can have very different symptoms, explains Munveer Bhangoo, MD, medical oncologist at Scripps Clinic.
  • #4 Testicular Cancer: Practice Essentials, Pathophysiology, Epidemiology
    https://emedicine.medscape.com/article/279007-overview
    Testicular cancers are an uncommon malignancy, representing only 0.5% of all new cancer cases in the United States. The American Cancer Society (ACS) estimates that about 9190 new cases of testicular cancer will be diagnosed during 2023 in the United States. The lifetime chance of developing testicular cancer is about one in 250 and the risk of dying is very low about one in 5,000. Most cases occur in men aged 20-34 years; the median age at diagnosis is approximately 32 years. […] In the United States, the incidence increased by 100% from 1988 to 2001. Diagnoses of seminomas increased 124% during that period and diagnoses of nonseminomas increased by 64%. No significant increase occurred in the incidence of early-stage disease in proportion to all diagnoses in this population, indicating that the increase was not due to more widespread screening or earlier detection.
  • #5 Testicular cancer: Symptoms, causes, and treatments
    https://www.medicalnewstoday.com/articles/166993
    Testicular cancer is a relatively rare type of cancer that occurs in the testicles, or testes. In the United States, around 1 in 250 males develop testicular cancer during their lifetime. In 2019, experts predict that 9,560 males will receive a diagnosis of testicular cancer. The average age at diagnosis is 33 years; the condition mostly affects young and middle aged men. In very rare cases, it can happen before puberty. Only 8% of cases occur after the age of 55. […] Testicular cancer is highly treatable, especially in the early stages. Most males with a diagnosis of testicular cancer will live at least another 5 years following diagnosis. […] A doctor will carry out surveillance after a person has had treatment for testicular cancer, to check for any signs that the cancer has come back. Surveillance does not involve active treatment, but the individual will attend regular appointments and undergo tests.
  • #6 Testicular Cancer: Practice Essentials, Pathophysiology, Epidemiology
    https://emedicine.medscape.com/article/279007-overview
    According to Surveillance, Epidemiology, and End Results (SEER) data from 18 geographic areas, the age-adjusted annual incidence of testicular cancer from 2016-2020 was 6.0 per 100,000 men. However, the incidence varies widely by race/ethnicity. […] Studies of testicular cancer in selected global populations from 1973-2007 have shown a clear trend toward an increased incidence in most populations evaluated. In recent years, however, rates have plateaued in some areas and even decreased in a few. […] Epidemiologic observations have suggested that environmental factors are instrumental in determining risk for testicular cancers. However, epidemiologic evidence does not consistently support any specific risk factor. […] The incidence of testicular cancer is fivefold higher in whites than in African Americans; however, African Americans tend to present with higher-grade disease and have much worse prognosis than whites. […] Testicular cancer can occur at any age but is most common between the ages of 15 and 35 years; about 50% of cases occur in men 20-34 years old. There is also a secondary peak in incidence after age 60.
  • #7 Testicular Cancer: Practice Essentials, Pathophysiology, Epidemiology
    https://emedicine.medscape.com/article/279007-overview
    According to Surveillance, Epidemiology, and End Results (SEER) data from 18 geographic areas, the age-adjusted annual incidence of testicular cancer from 2016-2020 was 6.0 per 100,000 men. However, the incidence varies widely by race/ethnicity. […] Studies of testicular cancer in selected global populations from 1973-2007 have shown a clear trend toward an increased incidence in most populations evaluated. In recent years, however, rates have plateaued in some areas and even decreased in a few. […] Epidemiologic observations have suggested that environmental factors are instrumental in determining risk for testicular cancers. However, epidemiologic evidence does not consistently support any specific risk factor. […] The incidence of testicular cancer is fivefold higher in whites than in African Americans; however, African Americans tend to present with higher-grade disease and have much worse prognosis than whites. […] Testicular cancer can occur at any age but is most common between the ages of 15 and 35 years; about 50% of cases occur in men 20-34 years old. There is also a secondary peak in incidence after age 60.
  • #8 Testicular cancer – Wikipedia
    https://en.wikipedia.org/wiki/Testicular_cancer
    Globally testicular cancer resulted in 8,300 deaths in 2013 up from 7,000 deaths in 1990. Testicular cancer has the highest prevalence in the U.S. and Europe, and is uncommon in Asia and Africa. Worldwide incidence has doubled since the 1960s, with the highest rates of prevalence in Scandinavia, Germany, and New Zealand. […] Although testicular cancer is most common among men aged 15-40 years, it has three peaks: infancy through the age of four as teratomas and yolk sac tumors, ages 25-40 years as post-pubertal seminomas and non-seminomas, and from age 60 as spermatocytic tumors. […] Germ cell tumors of the testis are the most common cancer in young men between the ages of 15 and 35 years. […] In the United States, about 8,900 cases are diagnosed a year. The risk of testicular cancer in white men is approximately 45 times the risk in black men, and more than three times that of Asian American men. The risk of testicular cancer in Latinos and American Indians is between that of white and Asian men. The cause of these differences is unknown. […] In the UK, approximately 2,000 people are diagnosed a year. Over a lifetime, the risk is roughly 1 in 200 (0.5%). It is the 16th most common cancer in men. It accounts for less than 1% of cancer deaths in men (around 60 men died in 2012).
  • #9 Testicular cancer – Wikipedia
    https://en.wikipedia.org/wiki/Testicular_cancer
    Globally testicular cancer resulted in 8,300 deaths in 2013 up from 7,000 deaths in 1990. Testicular cancer has the highest prevalence in the U.S. and Europe, and is uncommon in Asia and Africa. Worldwide incidence has doubled since the 1960s, with the highest rates of prevalence in Scandinavia, Germany, and New Zealand. […] Although testicular cancer is most common among men aged 15-40 years, it has three peaks: infancy through the age of four as teratomas and yolk sac tumors, ages 25-40 years as post-pubertal seminomas and non-seminomas, and from age 60 as spermatocytic tumors. […] Germ cell tumors of the testis are the most common cancer in young men between the ages of 15 and 35 years. […] In the United States, about 8,900 cases are diagnosed a year. The risk of testicular cancer in white men is approximately 45 times the risk in black men, and more than three times that of Asian American men. The risk of testicular cancer in Latinos and American Indians is between that of white and Asian men. The cause of these differences is unknown. […] In the UK, approximately 2,000 people are diagnosed a year. Over a lifetime, the risk is roughly 1 in 200 (0.5%). It is the 16th most common cancer in men. It accounts for less than 1% of cancer deaths in men (around 60 men died in 2012).
  • #10 Testicular cancer – Wikipedia
    https://en.wikipedia.org/wiki/Testicular_cancer
    Globally testicular cancer resulted in 8,300 deaths in 2013 up from 7,000 deaths in 1990. Testicular cancer has the highest prevalence in the U.S. and Europe, and is uncommon in Asia and Africa. Worldwide incidence has doubled since the 1960s, with the highest rates of prevalence in Scandinavia, Germany, and New Zealand. […] Although testicular cancer is most common among men aged 15-40 years, it has three peaks: infancy through the age of four as teratomas and yolk sac tumors, ages 25-40 years as post-pubertal seminomas and non-seminomas, and from age 60 as spermatocytic tumors. […] Germ cell tumors of the testis are the most common cancer in young men between the ages of 15 and 35 years. […] In the United States, about 8,900 cases are diagnosed a year. The risk of testicular cancer in white men is approximately 45 times the risk in black men, and more than three times that of Asian American men. The risk of testicular cancer in Latinos and American Indians is between that of white and Asian men. The cause of these differences is unknown. […] In the UK, approximately 2,000 people are diagnosed a year. Over a lifetime, the risk is roughly 1 in 200 (0.5%). It is the 16th most common cancer in men. It accounts for less than 1% of cancer deaths in men (around 60 men died in 2012).
  • #11 Testicular cancer – Wikipedia
    https://en.wikipedia.org/wiki/Testicular_cancer
    Globally testicular cancer resulted in 8,300 deaths in 2013 up from 7,000 deaths in 1990. Testicular cancer has the highest prevalence in the U.S. and Europe, and is uncommon in Asia and Africa. Worldwide incidence has doubled since the 1960s, with the highest rates of prevalence in Scandinavia, Germany, and New Zealand. […] Although testicular cancer is most common among men aged 15-40 years, it has three peaks: infancy through the age of four as teratomas and yolk sac tumors, ages 25-40 years as post-pubertal seminomas and non-seminomas, and from age 60 as spermatocytic tumors. […] Germ cell tumors of the testis are the most common cancer in young men between the ages of 15 and 35 years. […] In the United States, about 8,900 cases are diagnosed a year. The risk of testicular cancer in white men is approximately 45 times the risk in black men, and more than three times that of Asian American men. The risk of testicular cancer in Latinos and American Indians is between that of white and Asian men. The cause of these differences is unknown. […] In the UK, approximately 2,000 people are diagnosed a year. Over a lifetime, the risk is roughly 1 in 200 (0.5%). It is the 16th most common cancer in men. It accounts for less than 1% of cancer deaths in men (around 60 men died in 2012).
  • #12 Testicular cancer – Wikipedia
    https://en.wikipedia.org/wiki/Testicular_cancer
    Globally testicular cancer resulted in 8,300 deaths in 2013 up from 7,000 deaths in 1990. Testicular cancer has the highest prevalence in the U.S. and Europe, and is uncommon in Asia and Africa. Worldwide incidence has doubled since the 1960s, with the highest rates of prevalence in Scandinavia, Germany, and New Zealand. […] Although testicular cancer is most common among men aged 15-40 years, it has three peaks: infancy through the age of four as teratomas and yolk sac tumors, ages 25-40 years as post-pubertal seminomas and non-seminomas, and from age 60 as spermatocytic tumors. […] Germ cell tumors of the testis are the most common cancer in young men between the ages of 15 and 35 years. […] In the United States, about 8,900 cases are diagnosed a year. The risk of testicular cancer in white men is approximately 45 times the risk in black men, and more than three times that of Asian American men. The risk of testicular cancer in Latinos and American Indians is between that of white and Asian men. The cause of these differences is unknown. […] In the UK, approximately 2,000 people are diagnosed a year. Over a lifetime, the risk is roughly 1 in 200 (0.5%). It is the 16th most common cancer in men. It accounts for less than 1% of cancer deaths in men (around 60 men died in 2012).
  • #13 Testicular cancer: Symptoms, causes, and treatments
    https://www.medicalnewstoday.com/articles/166993
    Testicular cancer is a relatively rare type of cancer that occurs in the testicles, or testes. In the United States, around 1 in 250 males develop testicular cancer during their lifetime. In 2019, experts predict that 9,560 males will receive a diagnosis of testicular cancer. The average age at diagnosis is 33 years; the condition mostly affects young and middle aged men. In very rare cases, it can happen before puberty. Only 8% of cases occur after the age of 55. […] Testicular cancer is highly treatable, especially in the early stages. Most males with a diagnosis of testicular cancer will live at least another 5 years following diagnosis. […] A doctor will carry out surveillance after a person has had treatment for testicular cancer, to check for any signs that the cancer has come back. Surveillance does not involve active treatment, but the individual will attend regular appointments and undergo tests.
  • #14 Diagnosis and Treatment of Early-Stage Testicular Cancer: AUA Guideline – American Urological Association
    https://www.auanet.org/guidelines-and-quality/guidelines/testicular-cancer-guideline
    Risk factors for developing testis cancer include germ cell neoplasia in situ (GCNIS), history of undescended testis (UDT)/ cryptorchidism, family history, and a personal history of testis cancer. Infertility is associated with the presence of GCT, though this association is thought to arise from inherent testicular dysfunction. GCNIS is the precursor lesion from which the majority of GCTs arise. Among men with invasive GCT, GCNIS is found in adjacent testicular parenchyma in 80-90%. Among men with GCNIS, the risk of developing invasive GCT is approximately 50% within 5 years. Men with cryptorchidism have a four to six fold increased risk of developing testis cancer in the affected testicle, but the relative risk (RR) falls to two to three fold if orchiopexy is performed before puberty. Studies assessing the cancer risk of UDT in the contralateral testis are conflicting, though a meta-analysis of cryptorchidism studies showed the contralateral descended testis is also at slightly increased risk of developing cancer (RR 1.74; 95% Confidence Interval [CI], 1.01 to 2.98). Men with a first-degree relative with GCT are at an increased risk of developing testis cancer and at an earlier age. Men with a personal history of testis cancer are at a 12-fold increased risk of developing GCT in the contralateral testis, but the 15-year cumulative incidence is only 2%.
  • #15 Diagnosis and Treatment of Early-Stage Testicular Cancer: AUA Guideline – American Urological Association
    https://www.auanet.org/guidelines-and-quality/guidelines/testicular-cancer-guideline
    Risk factors for developing testis cancer include germ cell neoplasia in situ (GCNIS), history of undescended testis (UDT)/ cryptorchidism, family history, and a personal history of testis cancer. Infertility is associated with the presence of GCT, though this association is thought to arise from inherent testicular dysfunction. GCNIS is the precursor lesion from which the majority of GCTs arise. Among men with invasive GCT, GCNIS is found in adjacent testicular parenchyma in 80-90%. Among men with GCNIS, the risk of developing invasive GCT is approximately 50% within 5 years. Men with cryptorchidism have a four to six fold increased risk of developing testis cancer in the affected testicle, but the relative risk (RR) falls to two to three fold if orchiopexy is performed before puberty. Studies assessing the cancer risk of UDT in the contralateral testis are conflicting, though a meta-analysis of cryptorchidism studies showed the contralateral descended testis is also at slightly increased risk of developing cancer (RR 1.74; 95% Confidence Interval [CI], 1.01 to 2.98). Men with a first-degree relative with GCT are at an increased risk of developing testis cancer and at an earlier age. Men with a personal history of testis cancer are at a 12-fold increased risk of developing GCT in the contralateral testis, but the 15-year cumulative incidence is only 2%.
  • #16 What Is Testicular Cancer? | UCLA Medical School
    https://medschool.ucla.edu/news-article/testicular-cancer-symptoms-treatment-and-causes
    Testicular cancer is relatively rare, accounting for only around 1% of all cancers in men. However, it is the most common type of cancer in young men aged 18 to 40. And the incidence of testicular cancer has been increasing over the past few decades. According to the American Cancer Society, about 9,190 new cases of testicular cancer will be diagnosed in the United States in 2023. […] Testicular cancer is most common in young men aged 18 to 40, although it can occur in men of any age. […] Testicular cancer risk factors include: Abnormal Testicle Development: Men who have a condition called cryptorchidism where one or both testicles fail to descend into the scrotum during fetal development have a higher risk of testicular cancer. […] Testicular cancer does have a tendency to run in families. So if a person has a father or a brother with a history of testicular cancer history, their chances of it are increased.
  • #17 Testicular lumps and swellings | NHS inform
    https://www.nhsinform.scot/illnesses-and-conditions/sexual-and-reproductive/testicular-lumps-and-swellings/
    Lumps and swellings in the testicles (balls) are relatively common in boys, men and anyone with testicles. […] Speak to your GP practice if you have: a lump in your testicles, swollen testicles, a change in the shape of your testicles, a change in the way your testicles feel, 1 testicle that has become bigger than the other, aching or discomfort in your testicles that does not go away. […] The vast majority of testicular lumps and swellings are caused by non-cancerous (benign) conditions. Most of these may not need treatment. […] If you have been diagnosed with testicular cancer, you will be cared for by a team of clinicians who will help decide the best treatment for you. Surgery to remove the affected testicle will be recommended in most cases and this may sometimes be followed by a course of chemotherapy or radiotherapy.
  • #18 Self Screening
    https://dph.illinois.gov/topics-services/life-stages-populations/mens-health/self-screening.html
    Testicular cancer occurs in the testicles (testes), which are located inside the scrotum, a loose bag of skin underneath the penis. Compared with other types of cancer, testicular cancer is rare. But for young men aged 15 to 34, testicular cancer is the most common cancer here in the United States. The cause of testicular cancer is unknown. […] Testicular cancer is highly treatable, even when cancer has spread beyond the testicle. Depending on the type and stage of testicular cancer, you may receive one of several treatments, or a combination of treatments. […] Regular testicular self-examinations can help identify growths early, when the chance for successful treatment of testicular cancer is highest. […] If you find a lump, see a doctor right away. The abnormality may not be cancer, but if it is, the chances are great it can spread if not stopped by treatment. Only a physician can make a positive diagnosis.
  • #19 Testicular Cancer Screening | Finding Testicular Cancer Early | American Cancer Society
    https://www.cancer.org/cancer/types/testicular-cancer/detection-diagnosis-staging/detection.html
    Most testicular cancers can be found at an early stage, when they’re small and haven’t spread. In some men, early testicular cancers cause symptoms that lead them to seek medical attention. Most of the time a lump on the testicle is the first symptom, or the testicle might be swollen or larger than normal. […] The American Cancer Society advises men to be aware of testicular cancer and to see a doctor right away if they find a lump in a testicle. […] Because regular testicular self-exams have not been studied enough to know if they reduce the death rate from this cancer, the ACS does not have a recommendation on regular testicular self-exams for all men.
  • #20 Scrotal Masses | AAFP
    https://www.aafp.org/pubs/afp/issues/2022/0800/scrotal-masses.html
    Scrotal and testicular masses can be broadly categorized into painful conditions, which include testicular torsion, torsion of the testicular appendage, and epididymitis, and painless conditions, which include hydrocele, varicocele, and testicular cancer. […] Testicular cancer is the most common solid tumor diagnosed in men between 15 and 34 years of age, and usually presents as a firm, unilateral nodule that is often but not necessarily painless. […] The U.S. Preventive Services Task Force recommends against screening for testicular cancer in asymptomatic average-risk adolescents and adult men because of the low prevalence of the disease and the high cure rates even in advanced cases. […] A varicocele is abnormal dilation of the pampiniform plexus, either caused by incompetence of the gonadal vein valves or external compression of the gonadal vein.
  • #21 Testicular Cancer | Rose City Urology in Tyler Texas
    https://www.rosecityurology.com/testicular-cancer.html
    Testicular cancer happens when cells in the testicle grow to form a tumor. This is rare. More than 90 percent of testicular cancers begin in the germ cells, which produce sperm. There are two types of germ cell cancers (GCTs). Seminoma can grow slowly and respond very well to radiation and chemotherapy. Non-seminoma can grow more quickly and can be less responsive to those treatments. There are a few types of non-seminomas: choriocarcinoma, embryonal carcinoma, teratoma and yolk sac tumors. […] Surveillance is a way to look for changes with normal checkups. These include a physical exam, tumor marker tests and imaging tests. Imaging tests start with an ultrasound of the scrotum. They can also involve chest x-rays or CT scans. Most men may be checked for signs of low testosterone as well. […] Surveillance is recommended for patients with Stage 0 and some Stage I cancers as described below.
  • #22 Testicular Cancer | Rose City Urology in Tyler Texas
    https://www.rosecityurology.com/testicular-cancer.html
    Testicular cancer happens when cells in the testicle grow to form a tumor. This is rare. More than 90 percent of testicular cancers begin in the germ cells, which produce sperm. There are two types of germ cell cancers (GCTs). Seminoma can grow slowly and respond very well to radiation and chemotherapy. Non-seminoma can grow more quickly and can be less responsive to those treatments. There are a few types of non-seminomas: choriocarcinoma, embryonal carcinoma, teratoma and yolk sac tumors. […] Surveillance is a way to look for changes with normal checkups. These include a physical exam, tumor marker tests and imaging tests. Imaging tests start with an ultrasound of the scrotum. They can also involve chest x-rays or CT scans. Most men may be checked for signs of low testosterone as well. […] Surveillance is recommended for patients with Stage 0 and some Stage I cancers as described below.
  • #23 Testicular Cancer | Rose City Urology in Tyler Texas
    https://www.rosecityurology.com/testicular-cancer.html
    Testicular cancer happens when cells in the testicle grow to form a tumor. This is rare. More than 90 percent of testicular cancers begin in the germ cells, which produce sperm. There are two types of germ cell cancers (GCTs). Seminoma can grow slowly and respond very well to radiation and chemotherapy. Non-seminoma can grow more quickly and can be less responsive to those treatments. There are a few types of non-seminomas: choriocarcinoma, embryonal carcinoma, teratoma and yolk sac tumors. […] Surveillance is a way to look for changes with normal checkups. These include a physical exam, tumor marker tests and imaging tests. Imaging tests start with an ultrasound of the scrotum. They can also involve chest x-rays or CT scans. Most men may be checked for signs of low testosterone as well. […] Surveillance is recommended for patients with Stage 0 and some Stage I cancers as described below.
  • #24 What Is Testicular Cancer? | UCLA Medical School
    https://medschool.ucla.edu/news-article/testicular-cancer-symptoms-treatment-and-causes
    Testicular cancer treatment depends on several factors, including the stage and type of cancer, as well as the patient’s overall health and preferences. […] In some cases, particularly for low-risk, early-stage cancers, doctors may recommend „watchful waiting” or surveillance instead of immediate treatment. This involves monitoring the cancer with regular exams and imaging tests to see if it changes or grows over time. […] The overall testicular cancer survival rate is quite high, with more than 95% of men diagnosed with testicular cancer surviving at least five years after their initial diagnosis, and many living for decades after treatment. […] Regular self-exams and routine medical check-ups can help detect testicular cancer early when it is most treatable and can increase the chances of a successful outcome. […] Testicular Cancer Awareness Month is an annual event observed in April to raise awareness about testicular cancer and promote education, prevention, and early detection of the disease.
  • #25 Testicle Lump: Causes, Symptoms, and Diagnosis
    https://www.healthline.com/health/testicle-lump
    A testicular lump, or testicular lump, is an abnormal mass that can form in the testicles. […] A testicular lump is a fairly common condition that can have many different causes. Testicular lumps can occur in men, teenage boys, or younger children. […] Testicular cancer isn’t common overall, but it’s the most common type of cancer among American men between the ages of 15 and 35. […] Your doctor can properly diagnose the cause of a testicular lump. […] Most testicular lumps can be diagnosed during a physical examination. However, your doctor may order other tests to confirm the diagnosis. […] Testicular cancer is treated using surgery, chemotherapy, radiation, and other methods. Your specific course of treatment will depend on how early your cancer is detected and other factors. […] Most cases of testicular lumps aren’t serious or cancerous. Testicular cancer is rare. It’s also highly treatable, and it’s curable if you find it early. […] Since it’s difficult to figure out the cause of a testicular lump based on your symptoms alone, it’s important to visit a doctor if you notice any changes.
  • #26 How Can I Tell If I Have Testicular Cancer? – Scripps Health
    https://www.scripps.org/news_items/7529-how-to-tell-if-you-have-testicular-cancer
    A sign of testicular cancer is when one or both testicles change in size or shape. This could be caused by a tumor or swelling in the testicle. […] Some men with testicular cancer may feel heaviness in their scrotum, the sac that holds the testicles. […] While testicular cancer is often painless, some people may experience pain or discomfort in the testicle or scrotum. […] If you have any of these symptoms, its important to see your doctor to rule out or confirm testicular cancer. […] A physical exam and an ultrasound are usually the first tests performed. […] Blood tests can show if there are tumor markers in the blood. These markers come from cancer cells and can be found in the blood. […] Sometimes, your doctor might suggest a biopsy to check for testicular cancer. […] If you have testicular cancer, your doctor will check how much the cancer has spread. […] Treatment for testicular cancer depends on the stage of the cancer, your health and preferences. […] Sometimes, the doctor may recommend surveillance. This means having regular check-ups and tests to keep an eye on the cancer.
  • #27 Testicular cancer: Symptoms, signs & treatment | Healthy Male
    https://healthymale.org.au/mens-health/testicular-cancer
    Testicular cancer occurs in 1 in 25,000-30,000 Australian men. Around 900 Australian men are diagnosed with testicular cancer each year and almost 90% of them are aged under 50 years. […] Although testicular cancer accounts for less than 1% of cancers in men, its the most common type of tumour in men aged in their 20s and 30s. […] Testicular cancer is diagnosed through an ultrasound to examine a testicular lump, and blood tests to measure molecules that indicate the presence of cancer. […] MRI or CT scans are used to look for the spread of cancer to other parts of the body.
  • #28 Testicular cancer: Symptoms, causes, and treatments
    https://www.medicalnewstoday.com/articles/166993
    Testicular cancer is a relatively rare type of cancer that occurs in the testicles, or testes. In the United States, around 1 in 250 males develop testicular cancer during their lifetime. In 2019, experts predict that 9,560 males will receive a diagnosis of testicular cancer. The average age at diagnosis is 33 years; the condition mostly affects young and middle aged men. In very rare cases, it can happen before puberty. Only 8% of cases occur after the age of 55. […] Testicular cancer is highly treatable, especially in the early stages. Most males with a diagnosis of testicular cancer will live at least another 5 years following diagnosis. […] A doctor will carry out surveillance after a person has had treatment for testicular cancer, to check for any signs that the cancer has come back. Surveillance does not involve active treatment, but the individual will attend regular appointments and undergo tests.
  • #29 Testicular Cancer | Testicular Cancer Symptoms | MedlinePlus
    https://medlineplus.gov/testicularcancer.html
    Testicular cancer is very rare. You can get it at any age, but it is most common in men between the ages of 20 and 39. […] The symptoms of testicular cancer may include: A painless lump or swelling in either testicle. […] Surveillance, which might be done after surgery. It means that your provider will closely follow your condition with regular exams and tests. You won’t get any further treatment unless there are changes in your test results. […] After you have finished your treatment, you will need regular follow-up testing to make sure that the cancer has not come back.
  • #30 About Testicular Cancer | Testicular Cancer Information | University Hospitals
    https://www.uhhospitals.org/services/cancer-services/genitourinary-cancer/testicular-cancer/about-testicular-cancer
    There are different types of treatment for patients with testicular cancer. […] Surveillance is closely following a patient’s condition without giving any treatment unless there are changes in test results. […] Follow-up tests may be needed. […] Men who have had testicular cancer have an increased risk of developing cancer in the other testicle. […] Long-term clinical exams are very important.
  • #31 Testicular Cancer: Practice Essentials, Pathophysiology, Epidemiology
    https://emedicine.medscape.com/article/279007-overview
    According to Surveillance, Epidemiology, and End Results (SEER) data from 18 geographic areas, the age-adjusted annual incidence of testicular cancer from 2016-2020 was 6.0 per 100,000 men. However, the incidence varies widely by race/ethnicity. […] Studies of testicular cancer in selected global populations from 1973-2007 have shown a clear trend toward an increased incidence in most populations evaluated. In recent years, however, rates have plateaued in some areas and even decreased in a few. […] Epidemiologic observations have suggested that environmental factors are instrumental in determining risk for testicular cancers. However, epidemiologic evidence does not consistently support any specific risk factor. […] The incidence of testicular cancer is fivefold higher in whites than in African Americans; however, African Americans tend to present with higher-grade disease and have much worse prognosis than whites. […] Testicular cancer can occur at any age but is most common between the ages of 15 and 35 years; about 50% of cases occur in men 20-34 years old. There is also a secondary peak in incidence after age 60.
  • #32 Diagnosing testicular lumps in primary care – PubMed
    https://pubmed.ncbi.nlm.nih.gov/29020728/
    Although the incidence of testicular cancer has increased over the past few decades, testicular tumours are still rare and many GPs will only see one or two new diagnoses in their career. […] In one UK study, out of 845 patients who had been referred with testicular lumps or pain, only 33 (4%) were diagnosed with testicular cancer. […] The vast majority (95-98%) of testicular cancers are germ cell tumours. […] In Western Europe, five-year survival for testicular cancer is approximately 95%. […] NICE recommends that men with non-painful enlargement or change in shape or texture of the testis should be referred via the two-week wait cancer pathway. […] Any painful or tender mass within the body of the testis which is not suggestive of infection should also be referred. […] GPs should refer patients for an urgent ultrasound if they are aged 20-40 with a hydrocele; if there is uncertainty as to whether the mass is intra-testicular or extra-testicular; or if the testis cannot be fully palpated.
  • #33 Selection of men for investigation of possible testicular cancer in primary care: a large case–control study using electronic patient records
    https://pmc.ncbi.nlm.nih.gov/articles/PMC6058651/
    Testicular cancer incidence has risen over the last two decades and is expected to continue to rise. […] There are no primary care studies on the clinical features of testicular cancer, with recent National Institute for Health and Care Excellence (NICE) guidance based solely upon clinical consensus. […] Nine features were independently associated with testicular cancer, the top three being testicular swelling (odds ratio [OR] 280, 95% confidence interval [CI] = 110 to 690), testicular lump (OR 270, 95% CI = 100 to 740), and scrotal swelling (OR 170, 95% CI = 35 to 800). […] Testicular enlargement carries a risk of cancer of 2.5% close to the current 3% threshold in UK referral guidance. […] The current NICE guidance for testicular cancer recommends urgent specialist referral for men with non-painful enlargement or a change in shape or texture of the testis.
  • #34 Selection of men for investigation of possible testicular cancer in primary care: a large case–control study using electronic patient records
    https://pmc.ncbi.nlm.nih.gov/articles/PMC6058651/
    Most of the symptoms of testicular enlargement or swelling have risks of cancer around 3%, supporting NICE’s recommendation for urgent referral. […] Testicular lump and testicular swelling were each strongly associated with cancer in the 50 years age group, with PPVs of 2.5% and 2.3%, values just below the 3% threshold for urgent referral. […] Recorded hydrocele, epididymis/orchitis, or testicular pain (especially when these lead to a second consultation) are important features of testicular cancer in primary care.
  • #35 Selection of men for investigation of possible testicular cancer in primary care: a large case–control study using electronic patient records
    https://pmc.ncbi.nlm.nih.gov/articles/PMC6058651/
    Most of the symptoms of testicular enlargement or swelling have risks of cancer around 3%, supporting NICE’s recommendation for urgent referral. […] Testicular lump and testicular swelling were each strongly associated with cancer in the 50 years age group, with PPVs of 2.5% and 2.3%, values just below the 3% threshold for urgent referral. […] Recorded hydrocele, epididymis/orchitis, or testicular pain (especially when these lead to a second consultation) are important features of testicular cancer in primary care.
  • #36 Testicular Cancer: Practice Essentials, Pathophysiology, Epidemiology
    https://emedicine.medscape.com/article/279007-overview
    According to Surveillance, Epidemiology, and End Results (SEER) data from 18 geographic areas, the age-adjusted annual incidence of testicular cancer from 2016-2020 was 6.0 per 100,000 men. However, the incidence varies widely by race/ethnicity. […] Studies of testicular cancer in selected global populations from 1973-2007 have shown a clear trend toward an increased incidence in most populations evaluated. In recent years, however, rates have plateaued in some areas and even decreased in a few. […] Epidemiologic observations have suggested that environmental factors are instrumental in determining risk for testicular cancers. However, epidemiologic evidence does not consistently support any specific risk factor. […] The incidence of testicular cancer is fivefold higher in whites than in African Americans; however, African Americans tend to present with higher-grade disease and have much worse prognosis than whites. […] Testicular cancer can occur at any age but is most common between the ages of 15 and 35 years; about 50% of cases occur in men 20-34 years old. There is also a secondary peak in incidence after age 60.
  • #37 Testicular Cancer: Practice Essentials, Pathophysiology, Epidemiology
    https://emedicine.medscape.com/article/279007-overview
    According to Surveillance, Epidemiology, and End Results (SEER) data from 18 geographic areas, the age-adjusted annual incidence of testicular cancer from 2016-2020 was 6.0 per 100,000 men. However, the incidence varies widely by race/ethnicity. […] Studies of testicular cancer in selected global populations from 1973-2007 have shown a clear trend toward an increased incidence in most populations evaluated. In recent years, however, rates have plateaued in some areas and even decreased in a few. […] Epidemiologic observations have suggested that environmental factors are instrumental in determining risk for testicular cancers. However, epidemiologic evidence does not consistently support any specific risk factor. […] The incidence of testicular cancer is fivefold higher in whites than in African Americans; however, African Americans tend to present with higher-grade disease and have much worse prognosis than whites. […] Testicular cancer can occur at any age but is most common between the ages of 15 and 35 years; about 50% of cases occur in men 20-34 years old. There is also a secondary peak in incidence after age 60.
  • #38 Diagnosing testicular lumps in primary care – PubMed
    https://pubmed.ncbi.nlm.nih.gov/29020728/
    Although the incidence of testicular cancer has increased over the past few decades, testicular tumours are still rare and many GPs will only see one or two new diagnoses in their career. […] In one UK study, out of 845 patients who had been referred with testicular lumps or pain, only 33 (4%) were diagnosed with testicular cancer. […] The vast majority (95-98%) of testicular cancers are germ cell tumours. […] In Western Europe, five-year survival for testicular cancer is approximately 95%. […] NICE recommends that men with non-painful enlargement or change in shape or texture of the testis should be referred via the two-week wait cancer pathway. […] Any painful or tender mass within the body of the testis which is not suggestive of infection should also be referred. […] GPs should refer patients for an urgent ultrasound if they are aged 20-40 with a hydrocele; if there is uncertainty as to whether the mass is intra-testicular or extra-testicular; or if the testis cannot be fully palpated.
  • #39 What Is Testicular Cancer? | UCLA Medical School
    https://medschool.ucla.edu/news-article/testicular-cancer-symptoms-treatment-and-causes
    Testicular cancer treatment depends on several factors, including the stage and type of cancer, as well as the patient’s overall health and preferences. […] In some cases, particularly for low-risk, early-stage cancers, doctors may recommend „watchful waiting” or surveillance instead of immediate treatment. This involves monitoring the cancer with regular exams and imaging tests to see if it changes or grows over time. […] The overall testicular cancer survival rate is quite high, with more than 95% of men diagnosed with testicular cancer surviving at least five years after their initial diagnosis, and many living for decades after treatment. […] Regular self-exams and routine medical check-ups can help detect testicular cancer early when it is most treatable and can increase the chances of a successful outcome. […] Testicular Cancer Awareness Month is an annual event observed in April to raise awareness about testicular cancer and promote education, prevention, and early detection of the disease.
  • #40 Diagnosis and Treatment of Early-Stage Testicular Cancer: AUA Guideline – American Urological Association
    https://www.auanet.org/guidelines-and-quality/guidelines/testicular-cancer-guideline
    Testis cancer is the most common solid malignancy in young males. Testis cancer is a relatively rare malignancy, with outcomes defined by specific cancer- and patient-related factors. The vast majority of men with testis cancer have low-stage disease (limited to the testis and retroperitoneum; clinical stages I-IIB); survival rates are high with standard therapy. A priority for those patients with low-stage disease is limiting the burden of therapy and treatment-related toxicity without compromising cancer control. Thus, surveillance has assumed an increasing role among those with cancer clinically confined to the testis. […] In 2019, an estimated 9,500 men will be diagnosed with testis cancer in the United States, and 400 will die from the disease. Testis cancer is the most common solid malignancy among men aged 20 to 40 years. The incidence rate is highest among Caucasians, lowest among African-Americans, and most rapidly increasing in Hispanic populations. Age-adjusted incidence has nearly doubled over the last 4 decades for unknown reasons, from 3.7 per 100,000 in 1975 to 6.4 per 100,000 in 2014. A stage migration of GCT has been observed, presumably due to increased awareness and earlier diagnosis. Between 1973 and 2014, the percentage of tumors diagnosed at a localized stage increased from 55% to 68% in the United States. Currently, less than 15% of men present with stage III disease (to the lungs, viscera, or non-regional lymph nodes).
  • #41 Testicular Cancer: Practice Essentials, Pathophysiology, Epidemiology
    https://emedicine.medscape.com/article/279007-overview
    Testicular cancers are an uncommon malignancy, representing only 0.5% of all new cancer cases in the United States. The American Cancer Society (ACS) estimates that about 9190 new cases of testicular cancer will be diagnosed during 2023 in the United States. The lifetime chance of developing testicular cancer is about one in 250 and the risk of dying is very low about one in 5,000. Most cases occur in men aged 20-34 years; the median age at diagnosis is approximately 32 years. […] In the United States, the incidence increased by 100% from 1988 to 2001. Diagnoses of seminomas increased 124% during that period and diagnoses of nonseminomas increased by 64%. No significant increase occurred in the incidence of early-stage disease in proportion to all diagnoses in this population, indicating that the increase was not due to more widespread screening or earlier detection.
  • #42 Testicular Cancer: Practice Essentials, Pathophysiology, Epidemiology
    https://emedicine.medscape.com/article/279007-overview
    Testicular cancers are an uncommon malignancy, representing only 0.5% of all new cancer cases in the United States. The American Cancer Society (ACS) estimates that about 9190 new cases of testicular cancer will be diagnosed during 2023 in the United States. The lifetime chance of developing testicular cancer is about one in 250 and the risk of dying is very low about one in 5,000. Most cases occur in men aged 20-34 years; the median age at diagnosis is approximately 32 years. […] In the United States, the incidence increased by 100% from 1988 to 2001. Diagnoses of seminomas increased 124% during that period and diagnoses of nonseminomas increased by 64%. No significant increase occurred in the incidence of early-stage disease in proportion to all diagnoses in this population, indicating that the increase was not due to more widespread screening or earlier detection.
  • #43 Testicular Cancer: Practice Essentials, Pathophysiology, Epidemiology
    https://emedicine.medscape.com/article/279007-overview
    According to Surveillance, Epidemiology, and End Results (SEER) data from 18 geographic areas, the age-adjusted annual incidence of testicular cancer from 2016-2020 was 6.0 per 100,000 men. However, the incidence varies widely by race/ethnicity. […] Studies of testicular cancer in selected global populations from 1973-2007 have shown a clear trend toward an increased incidence in most populations evaluated. In recent years, however, rates have plateaued in some areas and even decreased in a few. […] Epidemiologic observations have suggested that environmental factors are instrumental in determining risk for testicular cancers. However, epidemiologic evidence does not consistently support any specific risk factor. […] The incidence of testicular cancer is fivefold higher in whites than in African Americans; however, African Americans tend to present with higher-grade disease and have much worse prognosis than whites. […] Testicular cancer can occur at any age but is most common between the ages of 15 and 35 years; about 50% of cases occur in men 20-34 years old. There is also a secondary peak in incidence after age 60.
  • #44 Diagnosis and Treatment of Early-Stage Testicular Cancer: AUA Guideline – American Urological Association
    https://www.auanet.org/guidelines-and-quality/guidelines/testicular-cancer-guideline
    Testis cancer is the most common solid malignancy in young males. Testis cancer is a relatively rare malignancy, with outcomes defined by specific cancer- and patient-related factors. The vast majority of men with testis cancer have low-stage disease (limited to the testis and retroperitoneum; clinical stages I-IIB); survival rates are high with standard therapy. A priority for those patients with low-stage disease is limiting the burden of therapy and treatment-related toxicity without compromising cancer control. Thus, surveillance has assumed an increasing role among those with cancer clinically confined to the testis. […] In 2019, an estimated 9,500 men will be diagnosed with testis cancer in the United States, and 400 will die from the disease. Testis cancer is the most common solid malignancy among men aged 20 to 40 years. The incidence rate is highest among Caucasians, lowest among African-Americans, and most rapidly increasing in Hispanic populations. Age-adjusted incidence has nearly doubled over the last 4 decades for unknown reasons, from 3.7 per 100,000 in 1975 to 6.4 per 100,000 in 2014. A stage migration of GCT has been observed, presumably due to increased awareness and earlier diagnosis. Between 1973 and 2014, the percentage of tumors diagnosed at a localized stage increased from 55% to 68% in the United States. Currently, less than 15% of men present with stage III disease (to the lungs, viscera, or non-regional lymph nodes).
  • #45 What Is Testicular Cancer? | UCLA Medical School
    https://medschool.ucla.edu/news-article/testicular-cancer-symptoms-treatment-and-causes
    Testicular cancer treatment depends on several factors, including the stage and type of cancer, as well as the patient’s overall health and preferences. […] In some cases, particularly for low-risk, early-stage cancers, doctors may recommend „watchful waiting” or surveillance instead of immediate treatment. This involves monitoring the cancer with regular exams and imaging tests to see if it changes or grows over time. […] The overall testicular cancer survival rate is quite high, with more than 95% of men diagnosed with testicular cancer surviving at least five years after their initial diagnosis, and many living for decades after treatment. […] Regular self-exams and routine medical check-ups can help detect testicular cancer early when it is most treatable and can increase the chances of a successful outcome. […] Testicular Cancer Awareness Month is an annual event observed in April to raise awareness about testicular cancer and promote education, prevention, and early detection of the disease.
  • #46 How Can I Tell If I Have Testicular Cancer? – Scripps Health
    https://www.scripps.org/news_items/7529-how-to-tell-if-you-have-testicular-cancer
    Testicular cancer is a rare type of cancer, making up less than 1% of all cancers in men. But unlike most cancers, testicular cancer tends to develop at a younger age. It is the most common cancer in men 15 to 35. […] The American Cancer Society estimates 9,760 new cases of testicular cancer will be diagnosed and 500 people will die from the disease in 2024. […] The most common sign of testicular cancer is a lump or swelling in one of the testicles. This lump may be painless or may cause discomfort. […] Not all lumps in the testicles are cancer. Other conditions and health issues can cause the same symptoms, such as an injury or an infection. Still, its crucial to have any lumps or swelling checked by a doctor to rule out testicular cancer. […] Patients with testicular masses can have very different symptoms, explains Munveer Bhangoo, MD, medical oncologist at Scripps Clinic.
  • #47 What Is Testicular Cancer? | UCLA Medical School
    https://medschool.ucla.edu/news-article/testicular-cancer-symptoms-treatment-and-causes
    Testicular cancer treatment depends on several factors, including the stage and type of cancer, as well as the patient’s overall health and preferences. […] In some cases, particularly for low-risk, early-stage cancers, doctors may recommend „watchful waiting” or surveillance instead of immediate treatment. This involves monitoring the cancer with regular exams and imaging tests to see if it changes or grows over time. […] The overall testicular cancer survival rate is quite high, with more than 95% of men diagnosed with testicular cancer surviving at least five years after their initial diagnosis, and many living for decades after treatment. […] Regular self-exams and routine medical check-ups can help detect testicular cancer early when it is most treatable and can increase the chances of a successful outcome. […] Testicular Cancer Awareness Month is an annual event observed in April to raise awareness about testicular cancer and promote education, prevention, and early detection of the disease.
  • #48 Testicular cancer: Symptoms, signs & treatment | Healthy Male
    https://healthymale.org.au/mens-health/testicular-cancer
    Testicular cancer occurs in 1 in 25,000-30,000 Australian men. Around 900 Australian men are diagnosed with testicular cancer each year and almost 90% of them are aged under 50 years. […] Although testicular cancer accounts for less than 1% of cancers in men, its the most common type of tumour in men aged in their 20s and 30s. […] Testicular cancer is diagnosed through an ultrasound to examine a testicular lump, and blood tests to measure molecules that indicate the presence of cancer. […] MRI or CT scans are used to look for the spread of cancer to other parts of the body.
  • #49 Testicular cancer: Symptoms, causes, and treatments
    https://www.medicalnewstoday.com/articles/166993
    Testicular cancer is a relatively rare type of cancer that occurs in the testicles, or testes. In the United States, around 1 in 250 males develop testicular cancer during their lifetime. In 2019, experts predict that 9,560 males will receive a diagnosis of testicular cancer. The average age at diagnosis is 33 years; the condition mostly affects young and middle aged men. In very rare cases, it can happen before puberty. Only 8% of cases occur after the age of 55. […] Testicular cancer is highly treatable, especially in the early stages. Most males with a diagnosis of testicular cancer will live at least another 5 years following diagnosis. […] A doctor will carry out surveillance after a person has had treatment for testicular cancer, to check for any signs that the cancer has come back. Surveillance does not involve active treatment, but the individual will attend regular appointments and undergo tests.
  • #50 Men’s Health Conditions | Health First
    https://hf.org/healthcare-home/departments-services/mens-health/mens-health-conditions
    Testicular cancer is rare but responds very well to treatment with early detection. It is most commonly found in teens and men, ages 15 to 44, though it can occur at any age. Treatment ranges from surveillance to surgery, or radiation and chemotherapy. […] Monthly self-exams are a quick and painless way to stay on top of your testicular health and detect any unusual changes. […] Look and feel for lumps, swelling, or anything that doesn’t look right to you. Lumps or bumps on your testicles or pain in your testicles should be checked out by a doctor. […] If you notice anything unusual or any new changes, or if you are experiencing pain in your testicles, make an appointment with your primary care doctor as soon as possible. […] Other symptoms of testicular health concerns include: A painless lump in your testicle, Swelling of the testicle or a feeling of weight in your scrotum, Pain or a dull ache in your testicle, scrotum, or groin, Tenderness, pain, swelling, or changes in your breast tissue, Swelling of the epididymis, Testicular torsion, or twisting of the testicles, Fluid building up in the scrotum.
  • #51 Testicular lumps and swellings | NHS inform
    https://www.nhsinform.scot/illnesses-and-conditions/sexual-and-reproductive/testicular-lumps-and-swellings/
    Lumps and swellings in the testicles (balls) are relatively common in boys, men and anyone with testicles. […] Speak to your GP practice if you have: a lump in your testicles, swollen testicles, a change in the shape of your testicles, a change in the way your testicles feel, 1 testicle that has become bigger than the other, aching or discomfort in your testicles that does not go away. […] The vast majority of testicular lumps and swellings are caused by non-cancerous (benign) conditions. Most of these may not need treatment. […] If you have been diagnosed with testicular cancer, you will be cared for by a team of clinicians who will help decide the best treatment for you. Surgery to remove the affected testicle will be recommended in most cases and this may sometimes be followed by a course of chemotherapy or radiotherapy.
  • #52 Epididymitis and Orchitis: An Overview | AAFP
    https://www.aafp.org/pubs/afp/issues/2009/0401/p583.html
    Epididymitis and orchitis are commonly seen in the outpatient setting. Men between 14 and 35 years of age are most often affected, and Chlamydia trachomatis and Neisseria gonorrhoeae are the most common pathogens in this age group. […] In 2002, epididymitis or orchitis accounted for 1 in 144 outpatient visits (0.69 percent) in men 18 to 50 years of age. There are approximately 600,000 cases of epididymitis per year in the United States, most of which occur in men between 18 and 35 years of age. […] Epididymitis is more common than orchitis. In one outpatient study, orchitis occurred in 58 percent of men diagnosed with epididymitis. Isolated orchitis is rare and is generally associated with mumps infection in prepubertal boys (13 years or younger).
  • #53 Epididymitis and Orchitis: An Overview | AAFP
    https://www.aafp.org/pubs/afp/issues/2009/0401/p583.html
    Epididymitis and orchitis are commonly seen in the outpatient setting. Men between 14 and 35 years of age are most often affected, and Chlamydia trachomatis and Neisseria gonorrhoeae are the most common pathogens in this age group. […] In 2002, epididymitis or orchitis accounted for 1 in 144 outpatient visits (0.69 percent) in men 18 to 50 years of age. There are approximately 600,000 cases of epididymitis per year in the United States, most of which occur in men between 18 and 35 years of age. […] Epididymitis is more common than orchitis. In one outpatient study, orchitis occurred in 58 percent of men diagnosed with epididymitis. Isolated orchitis is rare and is generally associated with mumps infection in prepubertal boys (13 years or younger).
  • #54 What Is Testicular Cancer? | UCLA Medical School
    https://medschool.ucla.edu/news-article/testicular-cancer-symptoms-treatment-and-causes
    Testicular cancer treatment depends on several factors, including the stage and type of cancer, as well as the patient’s overall health and preferences. […] In some cases, particularly for low-risk, early-stage cancers, doctors may recommend „watchful waiting” or surveillance instead of immediate treatment. This involves monitoring the cancer with regular exams and imaging tests to see if it changes or grows over time. […] The overall testicular cancer survival rate is quite high, with more than 95% of men diagnosed with testicular cancer surviving at least five years after their initial diagnosis, and many living for decades after treatment. […] Regular self-exams and routine medical check-ups can help detect testicular cancer early when it is most treatable and can increase the chances of a successful outcome. […] Testicular Cancer Awareness Month is an annual event observed in April to raise awareness about testicular cancer and promote education, prevention, and early detection of the disease.
  • #55 What are the 5 warning signs of testicular cancer? FAQs and more
    https://www.medicalnewstoday.com/articles/what-are-5-warning-signs-of-testicular-cancer
    The five warning signs of testicular cancer may include swelling, pain, and heaviness in the testicle area, along with breast growth and early puberty in boys. […] However, not everyone has symptoms in the beginning stages, and many may not experience them even after the cancer spreads. […] Enlargement or swelling of a testicle is frequently the first sign. […] The swelling usually affects one side and uncommonly involves both sides. […] Although the initial swelling is not painful, approximately one-third of people with testicular cancer have dull pain. […] Some individuals may have a feeling of heaviness in the scrotum or lower belly. […] In rare cases, this occurs because some testicular cancers secrete high levels of human chorionic gonadotropin, a hormone that stimulates breast development.
  • #56 What are the 5 warning signs of testicular cancer? FAQs and more
    https://www.medicalnewstoday.com/articles/what-are-5-warning-signs-of-testicular-cancer
    Some testicular cancers can make male sex hormones. […] When testicular cancer spreads to other parts of the body, many people may not experience symptoms right away. […] Symptoms that may suggest the cancer has spread to other parts of the body include low back pain, confusion, and chest pain. […] Because it is possible for someone to have testicular cancer and not have symptoms, some doctors recommend that males perform monthly self-examinations. […] When a doctor catches testicular cancer in the very early stage, the outlook is positive.