Materiały źródłowe

• #1 Peanut Allergy: Symptoms, Reaction, Tests & Treatment

  https://my.clevelandclinic.org/health/diseases/21511-peanut-allergy

  Peanut allergies happen when your immune system tries to protect you from a protein in peanuts that it mistakenly thinks is harmful. […] Peanut allergies are the most common food-related cause of anaphylaxis, which can lead to swelling in your airways or a severe drop in blood pressure. […] Call 911 or go to the ER at the first sign of severe symptoms. […] Healthcare providers diagnose peanut allergies by talking to you about your symptoms and performing allergy testing. […] Testing for peanut allergies might include: Allergy skin test. A provider pricks your skin with tiny amounts of allergens (including peanut protein) to see if you develop a reaction. […] Allergy blood test. A provider tests your blood for IgE antibodies to allergens. High levels of antibodies to peanut protein can indicate an allergy to peanuts depending on your history.

• #2 Peanut Allergy and Component-Resolved Diagnostics Possibilities—What Are the Benefits?

  https://pmc.ncbi.nlm.nih.gov/articles/PMC10746123/

  Peanut allergy is a widespread and potentially life-threatening condition that affects both children and adults, with a growing incidence worldwide. […] Component-resolved diagnostics is a modern approach to allergy diagnosis that focuses on identifying specific allergenic proteins to provide precise diagnoses and personalized treatment plans. […] Component-resolved diagnostics is particularly valuable in peanut allergy diagnosis, helping to determine allergen components associated with severe reactions. […] The criterion standard, also called the gold standard, for diagnosing food allergy (including peanut allergy) remains an oral food challenge (OFC), ideally a double-blind placebo control food challenge (DBPCFC). […] The main advantage of BAT is its low invasiveness compared to provocation tests.

• #3 Peanut Allergy – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK538526/

  Most primary care clinicians will encounter patients with a food allergy. Peanut allergy is usually lifelong and potentially fatal. This activity addresses the evaluation and management of peanut allergies and highlights the role of the interprofessional team in the care of patients with this condition. […] Summarize the evaluation of a patient with a peanut allergy. […] Diagnosis of a peanut allergy relies on patient history and physical exam. The type/amount of food ingested, onset/duration of symptoms, and relieving factors are key in making an accurate diagnosis. […] Skin testing is the preferred testing method in those patients with a history compatible with food allergies. […] Ultimately a clinician-supervised oral food challenge is the best and most reliable method for diagnosing peanut allergy.

• #4 Peanut allergy – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/peanut-allergy/diagnosis-treatment/drc-20376181

  Talking with your healthcare team about your symptoms and medical history starts the process of diagnosis. A physical exam usually follows and these next steps may be needed: […] A blood test can measure your immune system’s response to certain foods. It checks the amount of allergy-type antibodies in your bloodstream, also known as immunoglobulin E (IgE) antibodies. […] All these sources may help confirm a peanut allergy. Or they may point to another cause such as food intolerance. […] If you think you have a peanut allergy, avoid contact with peanuts until you can meet with your care team. If you have a severe reaction, seek emergency help.

• #5 Peanut allergy – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/peanut-allergy/diagnosis-treatment/drc-20376181

  Talking with your healthcare team about your symptoms and medical history starts the process of diagnosis. A physical exam usually follows and these next steps may be needed: […] A blood test can measure your immune system’s response to certain foods. It checks the amount of allergy-type antibodies in your bloodstream, also known as immunoglobulin E (IgE) antibodies. […] All these sources may help confirm a peanut allergy. Or they may point to another cause such as food intolerance. […] If you think you have a peanut allergy, avoid contact with peanuts until you can meet with your care team. If you have a severe reaction, seek emergency help.

• #6 Peanut Allergy – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK538526/

  Most primary care clinicians will encounter patients with a food allergy. Peanut allergy is usually lifelong and potentially fatal. This activity addresses the evaluation and management of peanut allergies and highlights the role of the interprofessional team in the care of patients with this condition. […] Summarize the evaluation of a patient with a peanut allergy. […] Diagnosis of a peanut allergy relies on patient history and physical exam. The type/amount of food ingested, onset/duration of symptoms, and relieving factors are key in making an accurate diagnosis. […] Skin testing is the preferred testing method in those patients with a history compatible with food allergies. […] Ultimately a clinician-supervised oral food challenge is the best and most reliable method for diagnosing peanut allergy.

• #7 Peanut Allergy: Symptoms, Reaction, and Treatment

  https://www.webmd.com/allergies/peanut-allergy-explained

  To diagnose a peanut allergy, your doctor will first ask about your symptoms and medical history. Then, they may suggest a physical exam along with: […] A skin test. This can be used to diagnose a peanut allergy and rule out other types of allergies. A tiny amount of peanut extract is placed on the skin of your arm or back. Then, a doctor or nurse pricks your skin with a needle. If you’re allergic, a reaction will show up as a raised bump or rash. […] A blood test. A blood test looks for IgE antibodies in your blood, which are a sign of an allergic reaction. […] An oral food challenge. You’ll eat very small amounts of peanuts while in your doctor’s office, with medication on hand to treat you in case of a reaction. The amount of peanuts you eat will increase over time so the doctor can watch your response.

• #8 Peanut allergy

  https://dermnetnz.org/topics/peanut-allergy

  Peanut allergy is an adverse immune response to a peanut allergen. Peanut allergy is the most common cause of food-related anaphylaxis. Peanut allergy is principally a clinical diagnosis based on the rapid development of allergic symptoms and signs after eating a peanut. Skin prick testing and serum specific IgE tests are used to identify sensitisation and to confirm the diagnosis. Skin prick testing involves placing a drop of peanut allergen on the skin, then pricking the skin to see if a weal is produced within 15 minutes. The British Society of Allergy and Clinical Immunology (BSACI) states that a weal 8 mm in size is highly predictive of peanut allergy. Serum specific IgE testing, also known as radioallergosorbent testing (RAST), is performed to detect allergen-specific IgE in the blood. Specific IgE 15 kU/L is highly predictive of peanut allergy. These tests do not predict the severity of clinical allergy. […] Confirmed peanut allergy needs a comprehensive management plan, which should be shared with the patient’s wider family, school, and/or workplace.

• #9 Peanut allergy

  https://dermnetnz.org/topics/peanut-allergy

  Peanut allergy is an adverse immune response to a peanut allergen. Peanut allergy is the most common cause of food-related anaphylaxis. Peanut allergy is principally a clinical diagnosis based on the rapid development of allergic symptoms and signs after eating a peanut. Skin prick testing and serum specific IgE tests are used to identify sensitisation and to confirm the diagnosis. Skin prick testing involves placing a drop of peanut allergen on the skin, then pricking the skin to see if a weal is produced within 15 minutes. The British Society of Allergy and Clinical Immunology (BSACI) states that a weal 8 mm in size is highly predictive of peanut allergy. Serum specific IgE testing, also known as radioallergosorbent testing (RAST), is performed to detect allergen-specific IgE in the blood. Specific IgE 15 kU/L is highly predictive of peanut allergy. These tests do not predict the severity of clinical allergy. […] Confirmed peanut allergy needs a comprehensive management plan, which should be shared with the patient’s wider family, school, and/or workplace.

• #10

  https://link.springer.com/article/10.1007/s40629-021-00190-6

  The larger the wheal diameter in the skin prick test, the higher the probability that a clinically relevant peanut allergy is present. […] The gold standard of a diagnosis of primary peanut allergy is a standardized, double-blind, placebo-controlled oral food challenge (DBPCFC). Oral titrated peanut food challenges can also be performed openly. However, this option should only be considered if there is a very high probability of a negative result. […] The diagnosis of peanut allergy should always be made in the context of all diagnostic tools and in the individual context. Only with the help of the interaction of all diagnostic tools can it be determined whether the diagnosis of a primary (systemic) or possibly secondary (pollen-associated) peanut allergy or exclusion of peanut allergy can be made.

• #11 Peanut allergy – Diagnosis and treatment – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/peanut-allergy/diagnosis-treatment/drc-20376181

  Talking with your healthcare team about your symptoms and medical history starts the process of diagnosis. A physical exam usually follows and these next steps may be needed: […] A blood test can measure your immune system’s response to certain foods. It checks the amount of allergy-type antibodies in your bloodstream, also known as immunoglobulin E (IgE) antibodies. […] All these sources may help confirm a peanut allergy. Or they may point to another cause such as food intolerance. […] If you think you have a peanut allergy, avoid contact with peanuts until you can meet with your care team. If you have a severe reaction, seek emergency help.

• #12 Peanut allergy

  https://dermnetnz.org/topics/peanut-allergy

  Peanut allergy is an adverse immune response to a peanut allergen. Peanut allergy is the most common cause of food-related anaphylaxis. Peanut allergy is principally a clinical diagnosis based on the rapid development of allergic symptoms and signs after eating a peanut. Skin prick testing and serum specific IgE tests are used to identify sensitisation and to confirm the diagnosis. Skin prick testing involves placing a drop of peanut allergen on the skin, then pricking the skin to see if a weal is produced within 15 minutes. The British Society of Allergy and Clinical Immunology (BSACI) states that a weal 8 mm in size is highly predictive of peanut allergy. Serum specific IgE testing, also known as radioallergosorbent testing (RAST), is performed to detect allergen-specific IgE in the blood. Specific IgE 15 kU/L is highly predictive of peanut allergy. These tests do not predict the severity of clinical allergy. […] Confirmed peanut allergy needs a comprehensive management plan, which should be shared with the patient’s wider family, school, and/or workplace.

• #13 Peanut allergy

  https://dermnetnz.org/topics/peanut-allergy

  Peanut allergy is an adverse immune response to a peanut allergen. Peanut allergy is the most common cause of food-related anaphylaxis. Peanut allergy is principally a clinical diagnosis based on the rapid development of allergic symptoms and signs after eating a peanut. Skin prick testing and serum specific IgE tests are used to identify sensitisation and to confirm the diagnosis. Skin prick testing involves placing a drop of peanut allergen on the skin, then pricking the skin to see if a weal is produced within 15 minutes. The British Society of Allergy and Clinical Immunology (BSACI) states that a weal 8 mm in size is highly predictive of peanut allergy. Serum specific IgE testing, also known as radioallergosorbent testing (RAST), is performed to detect allergen-specific IgE in the blood. Specific IgE 15 kU/L is highly predictive of peanut allergy. These tests do not predict the severity of clinical allergy. […] Confirmed peanut allergy needs a comprehensive management plan, which should be shared with the patient’s wider family, school, and/or workplace.

• #14 What Food Allergy Tests Mean

  https://kidswithfoodallergies.org/living-with-food-allergies/new-food-allergy-diagnosis/what-food-allergy-tests-mean/

  When trying to determine whether a child has a food allergy, allergy tests can be helpful tools in making a diagnosis. […] Doctors usually dont recommend allergy testing for non-IgE-mediated reactions. Allergy testing is not helpful for diagnosing this type of food allergy. […] If the doctor thinks your child may have an IgE-mediated food allergy, they may order allergy testing to help confirm the diagnosis. […] The four most common types of allergy tests are: Skin prick test, Specific IgE (sIgE) blood test, Component test, Oral food challenge. […] An oral food challenge (OFC) is a test done in your doctors office where an allergist and their staff feed your child increasing amounts of their suspected food allergen. […] OFCs are considered the gold standard for food allergy testing. […] With SPT and sIgE blood test, a positive test result for food allergy does not mean your child has a food allergy by itself. These tests are best used to help confirm a possible history for an IgE-mediated food allergy and should not be used as screening tests, at home tests, or large panels.

• #15 Peanut Allergy and Component-Resolved Diagnostics Possibilities—What Are the Benefits?

  https://pmc.ncbi.nlm.nih.gov/articles/PMC10746123/

  Peanut allergy is a widespread and potentially life-threatening condition that affects both children and adults, with a growing incidence worldwide. […] Component-resolved diagnostics is a modern approach to allergy diagnosis that focuses on identifying specific allergenic proteins to provide precise diagnoses and personalized treatment plans. […] Component-resolved diagnostics is particularly valuable in peanut allergy diagnosis, helping to determine allergen components associated with severe reactions. […] The criterion standard, also called the gold standard, for diagnosing food allergy (including peanut allergy) remains an oral food challenge (OFC), ideally a double-blind placebo control food challenge (DBPCFC). […] The main advantage of BAT is its low invasiveness compared to provocation tests.

• #16 Peanut Allergy and Component-Resolved Diagnostics Possibilities—What Are the Benefits?

  https://www.mdpi.com/2072-6643/15/24/5132

  Other tests, like the skin prick test (SPT), serum specific IgE (sIgE), basophil activation test (BAT), and serum specific IgE to allergen molecules (CRD), are performed in clinical practice. […] The main advantage of BAT is its low invasiveness compared to provocation tests. […] Component-resolved diagnostics (CRD) is a modern approach that enables the analysis of specific IgE antibodies against tightly defined molecules (components) that constitute the allergen. […] The primary applications of CRD in peanut allergy involve identifying sIgE levels of an individual to specific peanut molecules. […] The identification of specific components can contribute to assessing a patient’s potential risk of anaphylaxis in response to peanut consumption, as certain components may be associated with a higher likelihood of severe allergic reactions.

• #17 Peanut Allergy and Component-Resolved Diagnostics Possibilities—What Are the Benefits?

  https://pmc.ncbi.nlm.nih.gov/articles/PMC10746123/

  Another diagnostic option is measuring specific IgE antibodies for the extraction of a particular allergen. […] The primary applications of CRD in peanut allergy involve identifying sIgE levels of an individual to specific peanut molecules. […] The identification of specific components can contribute to assessing a patients potential risk of anaphylaxis in response to peanut consumption, as certain components may be associated with a higher likelihood of severe allergic reactions. […] SIgE to Ara h 2 had the best diagnostic accuracy measures (optimal positive/negative likelihood ratio), and with its very high specificity, it is the best single test for peanut allergy diagnosis because it significantly reduces false positive diagnosis. […] CRD can be treated as an equivalent to IgE and SPT in confirming peanut allergy in patients at high clinical risk.

• #18 PEANT – Overview: Peanut, IgE with Reflex to Peanut Components, IgE, Serum

  https://www.mayocliniclabs.com/test-catalog/overview/64756

  Evaluating patients with suspected peanut allergy […] The diagnosis of peanut allergy is dependent upon the presence of compatible clinical symptoms in the context of peanut exposure, with support from identification of potential peanut-specific IgE allergen antibodies, either by skin testing or in vitro serology testing. […] Once an elevated antibody response to total peanut IgE extract is established, assessment for the presence of specific IgE antibodies to the most common peanut allergenic components will be performed. […] Testing begins with analysis of peanut IgE. If peanut IgE is negative (<0.10 kU/L), testing is complete. [...] If peanut IgE is 0.10 kU/L or greater, then 7 peanut components (Ara h 2, Ara h 1, Ara h 3, Ara h 6, Ara h 8, Ara h 9, and profilin Bet v2) are performed at an additional charge.

• #19 Peanut Allergy and Component-Resolved Diagnostics Possibilities—What Are the Benefits?

  https://pmc.ncbi.nlm.nih.gov/articles/PMC10746123/

  Another diagnostic option is measuring specific IgE antibodies for the extraction of a particular allergen. […] The primary applications of CRD in peanut allergy involve identifying sIgE levels of an individual to specific peanut molecules. […] The identification of specific components can contribute to assessing a patients potential risk of anaphylaxis in response to peanut consumption, as certain components may be associated with a higher likelihood of severe allergic reactions. […] SIgE to Ara h 2 had the best diagnostic accuracy measures (optimal positive/negative likelihood ratio), and with its very high specificity, it is the best single test for peanut allergy diagnosis because it significantly reduces false positive diagnosis. […] CRD can be treated as an equivalent to IgE and SPT in confirming peanut allergy in patients at high clinical risk.

• #20 603916: Allergen Profile, Peanut, IgE With Component Reflexes | Labcorp

  https://www.labcorp.com/tests/603916/allergen-profile-peanut-ige-with-component-reflexes

  IgE to Ara h 2 has the best discriminative ability of all diagnostic tests for peanut allergy. It can accurately diagnose peanut allergy in 28% of patients but cannot be used to exclude a peanut allergy in an adult population. […] The presence of antibodies to Ara h 1 and/or Ara h 3 increases the risk of severe reactions. […] Reactivity to these dominant allergens at the time of diagnosis in a population of North American infants and toddlers with early-onset peanut allergy was found to be associated with future allergy persistence at age 13 years. […] Ara h 6 is a major peanut allergen showing similarity with Ara h 2 in many aspects. […] Up to 4 out of 100 peanut allergic patients are monosensitized to Ara h 6. […] IgE antibodies to the Ara h 8 are seldom associated with systemic reactions but more often to local reactions like oral allergy syndrome.

• #21 Peanut Allergy and Component-Resolved Diagnostics Possibilities—What Are the Benefits?

  https://pmc.ncbi.nlm.nih.gov/articles/PMC10746123/

  Another diagnostic option is measuring specific IgE antibodies for the extraction of a particular allergen. […] The primary applications of CRD in peanut allergy involve identifying sIgE levels of an individual to specific peanut molecules. […] The identification of specific components can contribute to assessing a patients potential risk of anaphylaxis in response to peanut consumption, as certain components may be associated with a higher likelihood of severe allergic reactions. […] SIgE to Ara h 2 had the best diagnostic accuracy measures (optimal positive/negative likelihood ratio), and with its very high specificity, it is the best single test for peanut allergy diagnosis because it significantly reduces false positive diagnosis. […] CRD can be treated as an equivalent to IgE and SPT in confirming peanut allergy in patients at high clinical risk.

• #22 Peanut Allergy and Component-Resolved Diagnostics Possibilities—What Are the Benefits?

  https://pmc.ncbi.nlm.nih.gov/articles/PMC10746123/

  Additionally, CRD should be performed in patients with an uncertain peanut allergy history and a positive SPT/sIgE to whole peanuts. […] The use of CRD, specifically the measurement of Ara h 6 and Ara h 2 among others, is applied in assessing the risk of a severe allergic reaction. […] CRD may be useful in predicting peanut immunotherapy effectiveness and durability of tolerance.

• #23 Peanut Allergy and Component-Resolved Diagnostics Possibilities—What Are the Benefits?

  https://pmc.ncbi.nlm.nih.gov/articles/PMC10746123/

  Additionally, CRD should be performed in patients with an uncertain peanut allergy history and a positive SPT/sIgE to whole peanuts. […] The use of CRD, specifically the measurement of Ara h 6 and Ara h 2 among others, is applied in assessing the risk of a severe allergic reaction. […] CRD may be useful in predicting peanut immunotherapy effectiveness and durability of tolerance.

• #24 Peanut Allergy and Component-Resolved Diagnostics Possibilities—What Are the Benefits?

  https://pmc.ncbi.nlm.nih.gov/articles/PMC10746123/

  Peanut allergy is a widespread and potentially life-threatening condition that affects both children and adults, with a growing incidence worldwide. […] Component-resolved diagnostics is a modern approach to allergy diagnosis that focuses on identifying specific allergenic proteins to provide precise diagnoses and personalized treatment plans. […] Component-resolved diagnostics is particularly valuable in peanut allergy diagnosis, helping to determine allergen components associated with severe reactions. […] The criterion standard, also called the gold standard, for diagnosing food allergy (including peanut allergy) remains an oral food challenge (OFC), ideally a double-blind placebo control food challenge (DBPCFC). […] The main advantage of BAT is its low invasiveness compared to provocation tests.

• #25 A New Diagnostic Test for Peanut Allergy – FoodAllergy.org

  https://www.foodallergy.org/fare-blog/new-diagnostic-test-peanut-allergy

  A new method for diagnosing peanut allergy was outlined in a letter published last month in the Journal of Allergy and Clinical Immunology (JACI). This mast cell activation test was compared to other available diagnostic tests on the basis of sensitivity (the rate of true positive tests, in which a disease is successfully identified) and specificity (the rate of true negative tests, in which a disease that isnt present is successfully ruled out). […] Each test currently used to diagnose peanut allergy has some drawbacks: […] Developed by researchers at Kings College London, the new test described in the JACI letter is based on the activation of mast cells, which are similar to basophils and play a key role in allergic reactions. […] This mast cell activation test (MAT) assesses the extent to which peanut-treated serum from patients blood samples can trigger allergy-associated changes in commercially available cultured mast cells.

• #26 Peanut Allergy Diagnosis With New Blood Test

  https://www.healthline.com/health-news/new-blood-test-may-provide-safer-cheaper-way-to-detect-peanut-allergies

  Researchers are developing a blood test for peanut allergies that could eliminate the need for the sometimes risky and expensive oral food challenge. […] A new blood test could make diagnosing peanut allergies a safer and cheaper process. […] The current method for diagnosing a peanut allergy uses a skin prick or IgE test to check for specific antibodies. But these exams can result in overdiagnosis and false positives. […] The new blood test, called the mast activation test (MAT), could act as a secondary tool if skin prick test results are inconclusive. […] The MAT is highly specific, meaning that when it’s positive it confirms peanut allergy with high certainty, reducing the number of patients needing challenges and particularly the number of patients reacting during challenges. […] The researchers said the MAT identified peanut allergies with a 98 percent specificity.

• #27 Reliable blood test (indirect BAT) for peanut allergy diagnosis

  https://www.aaaai.org/tools-for-the-public/latest-research-summaries/the-journal-of-allergy-and-clinical-immunology-in/2022/blood

  The gold standard for the diagnosis of a peanut allergy is an oral food challenge (OFC), but this is a time-consuming, patient-unfriendly and expensive test. A relatively cheap new blood test is the direct Basophil Activation Test (BAT), which mimics an allergic reaction in vitro. The direct BAT for peanut has shown to be a promising diagnostic tool for replacing the OFC. […] In The Journal of Allergy and Clinical Immunology: In Practice, Ruinemans-Koerts et al. evaluated and validated a new type of BAT, using donor basophils and only a small amount of patient serum (which can be stored for a long time); i.e. the indirect BAT. […] The combined basophil reactivity for Ara h2 and Ara h6 showed the highest accuracy (94%) for the diagnosis of a peanut allergy, with positive and negative predictive values of 96% and 89%, respectively.

• #28 Peanut Allergy and Component-Resolved Diagnostics Possibilities—What Are the Benefits?

  https://pmc.ncbi.nlm.nih.gov/articles/PMC10746123/

  Peanut allergy is a widespread and potentially life-threatening condition that affects both children and adults, with a growing incidence worldwide. […] Component-resolved diagnostics is a modern approach to allergy diagnosis that focuses on identifying specific allergenic proteins to provide precise diagnoses and personalized treatment plans. […] Component-resolved diagnostics is particularly valuable in peanut allergy diagnosis, helping to determine allergen components associated with severe reactions. […] The criterion standard, also called the gold standard, for diagnosing food allergy (including peanut allergy) remains an oral food challenge (OFC), ideally a double-blind placebo control food challenge (DBPCFC). […] The main advantage of BAT is its low invasiveness compared to provocation tests.

• #29

  https://link.springer.com/article/10.1007/s40629-021-00190-6

  Accurate diagnosis of a primary, systemic peanut allergy is of crucial importance for affected individuals and their families. A confirmed diagnosis can protect those affected from future allergic and even severe life-threatening events and support them in their ability to cope with the disease. […] The diagnosis of IgE-mediated peanut allergy is based on several key diagnostic elements. Building on a thorough history (including dietary and symptom diary if necessary), a key element is the detection of peanut-specific sensitization. This can be done by skin prick tests or in vitro by determining the specific IgE against peanut extract or against individual proteins of peanut in the serum (component diagnostics). Finally, oral provocation testing is still considered the gold standard of diagnosis and clinical proof of peanut allergy.

• #30 Peanut Allergy: Symptoms, Reaction, Tests & Treatment

  https://my.clevelandclinic.org/health/diseases/21511-peanut-allergy

  Food challenge test. Under the supervision of your provider, you’ll eat small, increasing amounts of peanut protein or peanut butter to see if you have a reaction. […] The best way to manage peanut allergies is to avoid peanuts and food containing peanuts. […] If you’re accidentally exposed to peanuts and have an allergic reaction, your provider might give you or recommend you take or carry: An epinephrine auto-injector (EpiPen or Auvi-Q) to use at the first signs of a severe allergic reaction. […] If you think you or your child has a peanut allergy, talk to a healthcare provider (and avoid peanuts and peanut products until you do).

• #31 Peanut Allergy and Component-Resolved Diagnostics Possibilities—What Are the Benefits?

  https://www.mdpi.com/2072-6643/15/24/5132

  Peanut allergy is a widespread and potentially life-threatening condition that affects both children and adults, with a growing incidence worldwide. […] Component-resolved diagnostics is a modern approach to allergy diagnosis that focuses on identifying specific allergenic proteins to provide precise diagnoses and personalized treatment plans. […] Component-resolved diagnostics is particularly valuable in peanut allergy diagnosis, helping to determine allergen components associated with severe reactions. […] The criterion standard, also called the “gold standard”, for diagnosing food allergy (including peanut allergy) remains an oral food challenge (OFC), ideally a double-blind placebo control food challenge (DBPCFC). […] The initial dose of 3 mg of food protein (which is 12.5 mg of peanut butter with 24% protein content) seems adequate, and the maximum is usually 3 g of food protein.

• #32 How Does a Doctor Diagnose a Peanut Allergy? | Oak Brook Allergists

  https://www.oakbrookallergists.com/2021/07/09/how-does-a-doctor-diagnose-a-peanut-allergy/

  Allergic reactions to peanuts can be severe and may manifest early in life. So, it’s crucial to have this diagnosed right away to prevent any life-threatening reactions. […] The best way to confirm this food allergy is to get diagnosed by a peanut allergy doctor. Being informed is the best way to save you from severe allergic responses in the future. […] Diagnosis starts with a discussion about your symptoms and medical history. […] A physical examination follows shortly after the discussion. After your assessment, your peanut allergy doctor may ask you to do the following: […] Your peanut allergy doctor may recommend an elimination diet if the cause of your symptoms is still uncertain. […] Your peanut allergy doctor may make you undergo a skin test. […] A blood test works by quantifying your immune system’s response to peanuts. Your doctor will measure the number of immunoglobulin E (IgE) antibodies in your blood. High IgE numbers indicate an allergy.

• #33 Recent Advances in Diagnosis and Therapy for Peanut Allergy – Page 2

  https://www.medscape.com/viewarticle/809522_2

  Several studies have suggested that component-resolved diagnostics could improve the specificity of peanut-allergy testing. […] Currently, such challenges are seldom performed in the clinic due to time and the labor-intensive nature of the procedures as well as the perceived risk for severe allergic reactions. […] However, it is important to point out that studies have not yet specifically correlated clinical severity with Ara h 2 IgE. […] Several functional assays such as the basophil activation tests and analysis of peanut-specific T-cell responses are currently being studied. However, currently there is a lack of evidence demonstrating that these tests have diagnostic value in peanut allergy. […] While not ready for prime time, combining component-resolved diagnostics, IgE epitope mapping and high-throughput microarray platforms may in the future allow for an assay that will result in better diagnostic capability and help identify patients at risk of persistent allergy.

• #34 Peanut Allergy Diagnosis: Current Practices, Emerging Technologies, and Future Directions

  https://www.mdpi.com/2313-5786/5/1/4

  The bead-based epitope assay (BBEA) is a new cutting-edge tool commercially available as of 2023 in the United States that is increasingly used to diagnose peanut allergy. […] Emerging diagnostic approaches for peanut allergy can be divided into molecular allergy diagnostics, microarray technology, basophil activation tests, genetic testing, novel imaging techniques, and machine learning and AI, each with distinct advantages and limitations. […] Peanut allergy diagnosis is evolving with advanced technologies like molecular diagnostics, microarray technology, basophil activation tests, genetic testing, and machine learning, which promise greater accuracy and personalized care compared to traditional methods such as skin prick testing, serum IgE testing, and oral food challenges.

• #35 Epitope Mapping Test Diagnoses Peanut Allergy 93% of The Time

  https://www.allergicliving.com/2021/06/15/epitope-mapping-test-diagnoses-peanut-allergy-with-over-90-accuracy/

  Epitope mapping blood test showed high rate of accuracy in peanut allergy. A blood test called “epitope mapping” accurately predicted peanut allergy 93 percent of the time, a recent study finds. Researchers say the new test is a significant improvement on existing tests for diagnosing peanut allergy, including skin prick tests and allergen-specific IgE blood tests. Those current tests can be unreliable in determining who will actually experience an allergic reaction to peanuts. […] But if those were inconclusive or I needed further evidence, I would order this test, says the director emeritus of the Jaffe Food Allergy Institute at the Icahn School of Medicine at Mount Sinai. […] He says the new test is also one step closer to being able to eliminate the need for the oral food challenge to diagnose a peanut allergy.

• #36 Epitope Mapping Test Diagnoses Peanut Allergy 93% of The Time

  https://www.allergicliving.com/2021/06/15/epitope-mapping-test-diagnoses-peanut-allergy-with-over-90-accuracy/

  The researchers found that positive tests are correct in 92 percent of cases, while negative tests were confirmed in 94 percent of cases. […] This test will significantly cut down those false positives in a way that will be very helpful to make a more informed diagnosis for peanut allergy, says Schroer, who wasn’t involved in the research. […] The accuracy of this novel test brings us one step closer to eliminating the need to subject patients to an oral food challenge to diagnose peanut allergy. […] Sampson and his team have previously published research using epitope mapping and IgE to predict which toddlers will grow out of a peanut allergy. […] They’re also studying epitope mapping to diagnose allergies to other foods, including milk, tree nuts and shrimp.

• #37 Epitope Mapping Test Diagnoses Peanut Allergy 93% of The Time

  https://www.allergicliving.com/2021/06/15/epitope-mapping-test-diagnoses-peanut-allergy-with-over-90-accuracy/

  The researchers found that positive tests are correct in 92 percent of cases, while negative tests were confirmed in 94 percent of cases. […] This test will significantly cut down those false positives in a way that will be very helpful to make a more informed diagnosis for peanut allergy, says Schroer, who wasn’t involved in the research. […] The accuracy of this novel test brings us one step closer to eliminating the need to subject patients to an oral food challenge to diagnose peanut allergy. […] Sampson and his team have previously published research using epitope mapping and IgE to predict which toddlers will grow out of a peanut allergy. […] They’re also studying epitope mapping to diagnose allergies to other foods, including milk, tree nuts and shrimp.

• #38 Researchers make a major advancement in food allergy diagnosis – The Brighter Side of News

  https://www.thebrighterside.news/post/researchers-make-a-major-advancement-in-food-allergy-diagnosis/

  The findings revealed that the Hoxb8 MAT exhibited exceptional diagnostic accuracy. Using a cutoff of 5.2% CD107a-positive cells, the test achieved a sensitivity of 93% and specificity of 96% at allergen concentrations of 100 ng/mL or higher. These results surpassed the diagnostic accuracy of both SPT and sIgE tests. […] The Hoxb8 MAT represents a significant advancement in allergy diagnostics. Unlike traditional tests, it accounts for the functional properties of IgE antibodies and integrates key parameters influencing allergic reactions. […] The development of the Hoxb8 MAT underscores the importance of innovation in addressing global health challenges. Food allergies affect up to 10% of the population in some regions, primarily young children. By offering a safer, more accurate diagnostic method, the Hoxb8 MAT has the potential to reduce unnecessary dietary restrictions and improve patient outcomes.

• #39 Researchers make a major advancement in food allergy diagnosis – The Brighter Side of News

  https://www.thebrighterside.news/post/researchers-make-a-major-advancement-in-food-allergy-diagnosis/

  The findings revealed that the Hoxb8 MAT exhibited exceptional diagnostic accuracy. Using a cutoff of 5.2% CD107a-positive cells, the test achieved a sensitivity of 93% and specificity of 96% at allergen concentrations of 100 ng/mL or higher. These results surpassed the diagnostic accuracy of both SPT and sIgE tests. […] The Hoxb8 MAT represents a significant advancement in allergy diagnostics. Unlike traditional tests, it accounts for the functional properties of IgE antibodies and integrates key parameters influencing allergic reactions. […] The development of the Hoxb8 MAT underscores the importance of innovation in addressing global health challenges. Food allergies affect up to 10% of the population in some regions, primarily young children. By offering a safer, more accurate diagnostic method, the Hoxb8 MAT has the potential to reduce unnecessary dietary restrictions and improve patient outcomes.

• #40 Peanut Allergy | Causes, Symptoms & Treatment | ACAAI Public Website

  https://acaai.org/allergies/allergic-conditions/food/peanut/

  An allergy to peanuts is among the most common food allergies found in children in the United States. […] If you suspect a peanut allergy, see an allergist for diagnosis and treatment. […] Diagnosing a peanut allergy can be complicated. Symptoms can vary from person to person, and a single individual may not always experience the same symptoms during every reaction. […] Your allergist may recommend a skin test or blood test to help diagnose whether you have a peanut allergy or allergy to another substance. […] If your child is determined to be high risk, the guidelines recommend having them tested for peanut allergy. Your allergist may do this with a skin test or blood test.

• #41 Diagnosing Food Allergies | Symptoms &Treatment | ACAAI Public Website

  https://acaai.org/allergies/testing-diagnosis/food-allergy-testing-and-diagnosis/

  Food allergy testing is a very important step in diagnosing food allergies. […] If done correctly and interpreted by a board-certified allergist, skin tests or blood tests are reliable and can rule food allergy in or out. […] Your allergist will interpret the test results and use them to aid in a diagnosis. […] Diagnosing food allergies can be complicated. Symptoms of food allergy can vary from person to person, and a single individual may not always experience the same symptoms during every reaction. […] Your allergist will look at both your test results and your medical history to make a food allergy diagnosis. […] If you are diagnosed with food allergies, your allergist will prescribe an epinephrine auto-injector and teach you how to use it.

• #42

  https://link.springer.com/article/10.1007/s40629-021-00190-6

  The larger the wheal diameter in the skin prick test, the higher the probability that a clinically relevant peanut allergy is present. […] The gold standard of a diagnosis of primary peanut allergy is a standardized, double-blind, placebo-controlled oral food challenge (DBPCFC). Oral titrated peanut food challenges can also be performed openly. However, this option should only be considered if there is a very high probability of a negative result. […] The diagnosis of peanut allergy should always be made in the context of all diagnostic tools and in the individual context. Only with the help of the interaction of all diagnostic tools can it be determined whether the diagnosis of a primary (systemic) or possibly secondary (pollen-associated) peanut allergy or exclusion of peanut allergy can be made.

• #43 Peanut Allergy Diagnosis: As Simple as Ara h 1, 2, and 3 | Consultant360

  https://www.consultant360.com/articles/peanut-allergy-diagnosis-simple-ara-h-1-2-and-3-0

  Among the challenges in using clinical testing for peanut and other food allergies is differentiating sensitization to an allergen from a genuine allergy. […] Genuine allergy is a positive allergy test with associated clinical signs or symptoms. […] There has been much debate and criticism of the overdiagnosis of food allergy in children based on only the positive result of a skin prick test or immunoassay. […] Historically, the diagnosis of allergy to peanuts and other foods relied on skin testing. […] However, the NIAID panel guidelines do recommend skin prick testing to be done by clinicians who are trained to properly interpret the test results and to be prepared in the office to treat a potential adverse reaction from testing. […] The sensitivity of these laboratory assays ranges from 60% to 95%, and their specificity ranges from 30% to 95%.

• #44 Peanut Allergy Diagnosis: As Simple as Ara h 1, 2, and 3 | Consultant360

  https://www.consultant360.com/articles/peanut-allergy-diagnosis-simple-ara-h-1-2-and-3-0

  Among the challenges in using clinical testing for peanut and other food allergies is differentiating sensitization to an allergen from a genuine allergy. […] Genuine allergy is a positive allergy test with associated clinical signs or symptoms. […] There has been much debate and criticism of the overdiagnosis of food allergy in children based on only the positive result of a skin prick test or immunoassay. […] Historically, the diagnosis of allergy to peanuts and other foods relied on skin testing. […] However, the NIAID panel guidelines do recommend skin prick testing to be done by clinicians who are trained to properly interpret the test results and to be prepared in the office to treat a potential adverse reaction from testing. […] The sensitivity of these laboratory assays ranges from 60% to 95%, and their specificity ranges from 30% to 95%.

• #45 Peanut Allergy Diagnosis: As Simple as Ara h 1, 2, and 3 | Consultant360

  https://www.consultant360.com/articles/peanut-allergy-diagnosis-simple-ara-h-1-2-and-3-0

  Among the challenges in using clinical testing for peanut and other food allergies is differentiating sensitization to an allergen from a genuine allergy. […] Genuine allergy is a positive allergy test with associated clinical signs or symptoms. […] There has been much debate and criticism of the overdiagnosis of food allergy in children based on only the positive result of a skin prick test or immunoassay. […] Historically, the diagnosis of allergy to peanuts and other foods relied on skin testing. […] However, the NIAID panel guidelines do recommend skin prick testing to be done by clinicians who are trained to properly interpret the test results and to be prepared in the office to treat a potential adverse reaction from testing. […] The sensitivity of these laboratory assays ranges from 60% to 95%, and their specificity ranges from 30% to 95%.

• #46 Peanut Allergy Diagnosis: Current Practices, Emerging Technologies, and Future Directions

  https://www.mdpi.com/2313-5786/5/1/4

  Peanut allergy presents a significant and growing public health concern, marked by its increasing prevalence and potential for severe allergic reactions. Traditional diagnostic methods, such as skin prick testing and serum IgE assays, serve as cornerstone approaches but often fall short in specificity, sensitivity, and risk stratification. […] This review explores the evolution of peanut allergy diagnostics, comparing traditional and emerging methodologies, and discusses their clinical implications, limitations, and future directions. The integration of advanced technologies with established approaches holds the potential to revolutionize peanut allergy diagnosis and management, ultimately enhancing patient care and outcomes. […] From a clinical standpoint, it is important to provide clarity regarding the diagnosis of peanut allergy to optimize health outcomes and limit health anxiety. In this paper, we will explore various diagnostic methods for peanut allergy, including both traditional approaches such as skin prick testing and serum IgE testing and emerging diagnostics like component-resolved diagnostics, oral food challenges, basophil and mast cell activation tests, bead-based epitope assays, genetic testing, microarray technology, novel imaging techniques, and the use of machine learning and artificial intelligence.

• #47 PEANT – Overview: Peanut, IgE with Reflex to Peanut Components, IgE, Serum

  https://www.mayocliniclabs.com/test-catalog/overview/64756

  Results from peanut specific IgE antibody testing must be interpreted in the context of patient’s clinical evaluation and history of allergen exposures. […] Negative results for IgE to total peanut and any peanut components do not completely exclude the possibility of clinically relevant allergic responses upon exposure to peanut. […] Positive results for IgE to total peanut or any potential peanut allergenic components are not diagnostic for peanut allergy, and only indicate patient may be sensitized to peanut or a cross-reactive allergen.

• #48 PEANT – Overview: Peanut, IgE with Reflex to Peanut Components, IgE, Serum

  https://www.mayocliniclabs.com/test-catalog/overview/64756

  Results from peanut specific IgE antibody testing must be interpreted in the context of patient’s clinical evaluation and history of allergen exposures. […] Negative results for IgE to total peanut and any peanut components do not completely exclude the possibility of clinically relevant allergic responses upon exposure to peanut. […] Positive results for IgE to total peanut or any potential peanut allergenic components are not diagnostic for peanut allergy, and only indicate patient may be sensitized to peanut or a cross-reactive allergen.

• #49 PEANT – Overview: Peanut, IgE with Reflex to Peanut Components, IgE, Serum

  https://www.mayocliniclabs.com/test-catalog/overview/64756

  Results from peanut specific IgE antibody testing must be interpreted in the context of patient’s clinical evaluation and history of allergen exposures. […] Negative results for IgE to total peanut and any peanut components do not completely exclude the possibility of clinically relevant allergic responses upon exposure to peanut. […] Positive results for IgE to total peanut or any potential peanut allergenic components are not diagnostic for peanut allergy, and only indicate patient may be sensitized to peanut or a cross-reactive allergen.

• #50 peanut diagnostic — allergenis provider site

  https://www.allergenis.com/peanut-diagnostic

  pioneering food allergy diagnostics, in that we are applying threshold data to inform clinical management for the first time. highly informative and highly accurate diagnostics for peanut allergies. Current food allergy current diagnostics have low specificity, contributing to the over-diagnosis of as many as 60 percent of patients. Diagnostic tests such as skin prick testing (SPT), peanut sIgE, or component testing have a low positive predictive value for making a diagnosis of food allergy but high negative predictive value. With high concordance to OFC, the allergenis peanut diagnostic or bead-based epitope assay (BBEA) promises to significantly increase diagnostic accuracy to be greater than SPT, sIgE, and CRD for patients with food allergies. current diagnostics do not provide threshold data. Despite current diagnostics launching nearly 40 years ago, there has been little development to improve accuracy or to provide threshold data for clinical management. allergenis set out to provide an accurate method of threshold assignment. The Allergenis test, a bead-based epitope assay, will be the only validated test to provide threshold data (besides an OFC). The Allergenis Peanut Diagnostic (also known as BBEA) is different than current blood tests. It is a molecular diagnostic test that looks for the mechanistic cause of an inappropriate immune response to peanut. The test is more than just an improvement over past technologies; the epitope technology has allowed us to identify specific epitopes tied to an immune response. This allows us much higher specificity and sensitivity (lowering the over-diagnosis of peanut allergies). Testing was validated using only samples with double-blind, placebo controlled oral food challenge results (gold standard). Testing does not require fresh whole blood; testing is performed off a small amount of plasma and takes 5-7 business days for results.

• #51 peanut diagnostic — allergenis provider site

  https://www.allergenis.com/peanut-diagnostic

  pioneering food allergy diagnostics, in that we are applying threshold data to inform clinical management for the first time. highly informative and highly accurate diagnostics for peanut allergies. Current food allergy current diagnostics have low specificity, contributing to the over-diagnosis of as many as 60 percent of patients. Diagnostic tests such as skin prick testing (SPT), peanut sIgE, or component testing have a low positive predictive value for making a diagnosis of food allergy but high negative predictive value. With high concordance to OFC, the allergenis peanut diagnostic or bead-based epitope assay (BBEA) promises to significantly increase diagnostic accuracy to be greater than SPT, sIgE, and CRD for patients with food allergies. current diagnostics do not provide threshold data. Despite current diagnostics launching nearly 40 years ago, there has been little development to improve accuracy or to provide threshold data for clinical management. allergenis set out to provide an accurate method of threshold assignment. The Allergenis test, a bead-based epitope assay, will be the only validated test to provide threshold data (besides an OFC). The Allergenis Peanut Diagnostic (also known as BBEA) is different than current blood tests. It is a molecular diagnostic test that looks for the mechanistic cause of an inappropriate immune response to peanut. The test is more than just an improvement over past technologies; the epitope technology has allowed us to identify specific epitopes tied to an immune response. This allows us much higher specificity and sensitivity (lowering the over-diagnosis of peanut allergies). Testing was validated using only samples with double-blind, placebo controlled oral food challenge results (gold standard). Testing does not require fresh whole blood; testing is performed off a small amount of plasma and takes 5-7 business days for results.

• #52 Peanut Allergy – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK538526/

  To date, the recommended management of peanut allergy relies on avoidance of peanut ingestion. […] Although avoidance is the mainstay of treatment, new strategies are being tested to prevent food allergies. Peanut immunotherapy clinical trials have been promising to date using incremental ingestion of small amounts of peanut over time with oral immunotherapy (OIT). […] Managing a peanut allergy usually involves an interprofessional team. The majority of patients are first seen by the primary care clinician.

• #53 Peanut, tree nut, and seed allergy: Diagnosis – UpToDate

  https://www.uptodate.com/contents/peanut-tree-nut-and-seed-allergy-diagnosis

  Peanut, tree nut, and seed allergies are some of the most common food allergies in both children and adults. These allergies tend to cause severe reactions and usually persist over time. […] The diagnosis of peanut, tree nut, and seed allergies is presented in this topic review. […] An unequivocal history of an immediate reaction consisting of typical allergic symptoms following the isolated ingestion of a peanut, tree nut, or seed product, supported by positive tests for specific immunoglobulin E (IgE) antibodies, is usually sufficient to establish the diagnosis for suspected IgE-mediated reactions. […] Either skin prick tests or in vitro tests for IgE are usually performed initially. […] With the exception of in vitro immunoassays for specific IgE, other diagnostic allergy procedures, including skin testing and food challenges, should be performed by allergy specialists with training in the management of serious allergic reactions.

• #54 Peanut Allergy | Allergy UK | National Charity

  https://www.allergyuk.org/resources/peanut-allergy-factsheet/

  Peanut allergy affects around 2% (1 in 50) of children in the UK and has been increasing in recent decades. […] It is important to seek advice from a Healthcare professional if a peanut allergy is suspected. In the first instance, this will usually be your GP. They may arrange for allergy testing to be carried out or refer you to a specialist allergy service for skin prick testing and/or specific IgE blood testing to peanut. These tests help to confirm if food allergy is likely and rule out other possible causes. […] Allergy tests cannot predict how mild or severe an allergic reaction will be, or when an allergic reaction is likely to happen. […] If you have had cause for concern over peanut allergy and have been avoiding peanuts, it is important not to reintroduce peanuts back into the diet without medical advice.

• #55 Peanut Allergy Diagnosis: Current Practices, Emerging Technologies, and Future Directions

  https://www.mdpi.com/2313-5786/5/1/4

  The bead-based epitope assay (BBEA) is a new cutting-edge tool commercially available as of 2023 in the United States that is increasingly used to diagnose peanut allergy. […] Emerging diagnostic approaches for peanut allergy can be divided into molecular allergy diagnostics, microarray technology, basophil activation tests, genetic testing, novel imaging techniques, and machine learning and AI, each with distinct advantages and limitations. […] Peanut allergy diagnosis is evolving with advanced technologies like molecular diagnostics, microarray technology, basophil activation tests, genetic testing, and machine learning, which promise greater accuracy and personalized care compared to traditional methods such as skin prick testing, serum IgE testing, and oral food challenges.

• #56 Peanut Allergy Diagnosis: Current Practices, Emerging Technologies, and Future Directions

  https://www.mdpi.com/2313-5786/5/1/4

  Peanut allergy presents a significant and growing public health concern, marked by its increasing prevalence and potential for severe allergic reactions. Traditional diagnostic methods, such as skin prick testing and serum IgE assays, serve as cornerstone approaches but often fall short in specificity, sensitivity, and risk stratification. […] This review explores the evolution of peanut allergy diagnostics, comparing traditional and emerging methodologies, and discusses their clinical implications, limitations, and future directions. The integration of advanced technologies with established approaches holds the potential to revolutionize peanut allergy diagnosis and management, ultimately enhancing patient care and outcomes. […] From a clinical standpoint, it is important to provide clarity regarding the diagnosis of peanut allergy to optimize health outcomes and limit health anxiety. In this paper, we will explore various diagnostic methods for peanut allergy, including both traditional approaches such as skin prick testing and serum IgE testing and emerging diagnostics like component-resolved diagnostics, oral food challenges, basophil and mast cell activation tests, bead-based epitope assays, genetic testing, microarray technology, novel imaging techniques, and the use of machine learning and artificial intelligence.

• #57 Allergenis Seeks to Change Peanut Allergy Testing | 360DxRSS FeedsVisit 360Dx on TwitterVisit 360Dx on LinkedIn

  https://www.360dx.com/immunoassays/allergenis-seeks-change-peanut-allergy-testing

  NEW YORK — Pennsylvania-based firm Allergenis plans to change the model for peanut allergy testing with its blood test, which it said can reduce false diagnoses of peanut allergies and give nuanced results that will help patients manage their individual risk. […] According to Allergenis, its laboratory-developed test produces fewer false positive results than other first-line assays — skin prick and peanut-specific immunoglobulin E tests — and fewer false negative results than skin prick tests in young patients. […] Allergenis said study results show its test is 93 percent accurate, a measurement achieved by testing patients with both the Allergenis assay and oral food challenge and comparing the results. […] The assay has 92 percent sensitivity, which is comparable to skin prick and IgE tests. Its big advantage is its 94 percent specificity.

• #58 Researchers make a major advancement in food allergy diagnosis – The Brighter Side of News

  https://www.thebrighterside.news/post/researchers-make-a-major-advancement-in-food-allergy-diagnosis/

  The findings revealed that the Hoxb8 MAT exhibited exceptional diagnostic accuracy. Using a cutoff of 5.2% CD107a-positive cells, the test achieved a sensitivity of 93% and specificity of 96% at allergen concentrations of 100 ng/mL or higher. These results surpassed the diagnostic accuracy of both SPT and sIgE tests. […] The Hoxb8 MAT represents a significant advancement in allergy diagnostics. Unlike traditional tests, it accounts for the functional properties of IgE antibodies and integrates key parameters influencing allergic reactions. […] The development of the Hoxb8 MAT underscores the importance of innovation in addressing global health challenges. Food allergies affect up to 10% of the population in some regions, primarily young children. By offering a safer, more accurate diagnostic method, the Hoxb8 MAT has the potential to reduce unnecessary dietary restrictions and improve patient outcomes.

• #59

  https://link.springer.com/article/10.1007/s40629-021-00190-6

  Peanut allergy is an immunoglobulin E (IgE)-mediated immune response that usually manifests in childhood and can range from mild skin reactions to anaphylaxis. Since quality of life may be greatly reduced by the diagnosis of peanut allergy, an accurate diagnosis should always be made. […] Important diagnostic elements include a detailed clinical history, detection of peanut-specific sensitization by skin prick testing and/or in vitro measurement of peanut (extract)-specific IgE and/or molecular components, and double-blind, placebo-controlled food challenge as the gold standard. […] The most important diagnostic measures in determining the diagnosis of peanut allergy are clinical history and detection of sensitizations, also via component-based diagnostics. However, in case of unclear results, the gold standard—an oral food challenge—should always be used.

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