Materiały źródłowe

• #1 Classification of distinct tendinopathy subtypes for precision therapeutics | Nature Communications

  https://www.nature.com/articles/s41467-024-53826-w

  Rotator cuff tendinopathy is the most common tendinopathy type with the worst prognosis. […] Conventional treatments often elicit heterogeneous drug responses due to the diversity of tendinopathy. […] Clinical treatment modalities for tendinopathy often elicit heterogeneous responses. […] Glucocorticoid therapy may not improve the prognosis and, in some cases, may even prove to be detrimental. […] Currently, the classification of tendinopathy is primarily based on factors such as onset time, clinical symptoms, and the size and morphology of tear ruptures. […] Commonly utilized one size fits all treatment strategies have resulted in variable therapeutic efficacy among different tendinopathy subtypes. […] Accurately diagnosing and selecting appropriate patients for targeted treatment is expected to improve the current state of tendinopathy therapy.

• #2 Outcome Predictors For Rotator Cuff Tendinopathy

  https://qmro.qmul.ac.uk/xmlui/handle/123456789/79938

  Outcome Predictors For Rotator Cuff Tendinopathy […] Rotator Cuff (RC) tendinopathy is common with a poor recovery rate and unclear prognosis. […] The impact of success would be improved clinical tools to assess and consider prognosis for RC tendinopathy. […] The model demonstrated acceptable accuracy (AUC=0.77) with 76% specificity and 74% sensitivity. […] Lower quality of life, worse night pain, worse unilateral morning stiffness, higher body mass index, higher fear avoidance and higher catastrophising explained 68% of the variance in RC tendinopathy severity (n=82, R2=0.68). […] The recovery rate was 47% occurring mainly around the 7 month follow-up. […] The final model (Chi-square= 9.99 and p= 0.007), including activity (Hazard ratio (95%) = 2.23 (1.084.61)) level and general health status (Hazard ratio (95%) = 1.03 (1.011.05)), partially predicted RC tendinopathy recovery, demonstrating moderate model performance and good internal validation (optimism-corrected Harrell’s C=0.66, calibration slope=0.99).

• #3 Long-term prognosis of patients with achilles tendinopathy. An observational 8-year follow-up study – PubMed

  https://pubmed.ncbi.nlm.nih.gov/11032217/

  To determine the long-term outcome of patients treated nonoperatively for acute or subchronic (duration of the symptoms before initiation of the treatment less than 6 months) Achilles tendinopathy, we performed a follow-up analysis on 83 of 107 patients an average 8 +/- 2 (SD) years after the initial contact. […] The results of our 8-year follow-up showed that the long-term prognosis of patients with acute-to-subchronic Achilles tendinopathy is favorable as determined by subjective and functional assessments.

• #4 Classification of distinct tendinopathy subtypes for precision therapeutics | Nature Communications

  https://www.nature.com/articles/s41467-024-53826-w

  Rotator cuff tendinopathy is the most common tendinopathy type with the worst prognosis. […] Conventional treatments often elicit heterogeneous drug responses due to the diversity of tendinopathy. […] Clinical treatment modalities for tendinopathy often elicit heterogeneous responses. […] Glucocorticoid therapy may not improve the prognosis and, in some cases, may even prove to be detrimental. […] Currently, the classification of tendinopathy is primarily based on factors such as onset time, clinical symptoms, and the size and morphology of tear ruptures. […] Commonly utilized one size fits all treatment strategies have resulted in variable therapeutic efficacy among different tendinopathy subtypes. […] Accurately diagnosing and selecting appropriate patients for targeted treatment is expected to improve the current state of tendinopathy therapy.

• #5 Outcome Predictors For Rotator Cuff Tendinopathy

  https://qmro.qmul.ac.uk/xmlui/handle/123456789/79938

  Outcome Predictors For Rotator Cuff Tendinopathy […] Rotator Cuff (RC) tendinopathy is common with a poor recovery rate and unclear prognosis. […] The impact of success would be improved clinical tools to assess and consider prognosis for RC tendinopathy. […] The model demonstrated acceptable accuracy (AUC=0.77) with 76% specificity and 74% sensitivity. […] Lower quality of life, worse night pain, worse unilateral morning stiffness, higher body mass index, higher fear avoidance and higher catastrophising explained 68% of the variance in RC tendinopathy severity (n=82, R2=0.68). […] The recovery rate was 47% occurring mainly around the 7 month follow-up. […] The final model (Chi-square= 9.99 and p= 0.007), including activity (Hazard ratio (95%) = 2.23 (1.084.61)) level and general health status (Hazard ratio (95%) = 1.03 (1.011.05)), partially predicted RC tendinopathy recovery, demonstrating moderate model performance and good internal validation (optimism-corrected Harrell’s C=0.66, calibration slope=0.99).

• #6 Predicting the outcome of plantar heel pain in adults: a systematic review of prognostic factors | Journal of Foot and Ankle Research | Full Text

  https://jfootankleres.biomedcentral.com/articles/10.1186/s13047-023-00626-y

  Plantar Heel Pain (PHP) is a common disorder with many treatment pathways and is not self-limiting, hence prognostic information concerning recovery or recalcitrance is needed to guide practice. […] A limited number of biomedical factors predict favourable or unfavourable PHP outcomes. High quality, adequately powered, prospective studies are required to better understand PHP recovery and should evaluate the prognostic value of a wide range of variables, including psychosocial factors. […] The single cohort study by Hansen et al., (2018) revealed that having bilateral heel pain and being female were predictive of a negative prognosis. […] There are limited biomedical factors which can be used to predict PHP outcomes. Having bilateral pain and being female should alert clinicians to an increased risk of a poor outcome. We identified modifiable and measurable factors such as pain status and a variety of ankle and hip kinematics, as being potential factors that predict the success of treatments such as shockwave therapy, anti-pronation taping and foot orthoses. These could assist informed clinical decisions regarding outcome expectations. To better understand PHP recovery or persistence, high quality prospective studies should evaluate the prognostic value of a range of variables, including psychosocial in addition to biological factors.

• #7 Predicting the outcome of plantar heel pain in adults: a systematic review of prognostic factors | Journal of Foot and Ankle Research | Full Text

  https://jfootankleres.biomedcentral.com/articles/10.1186/s13047-023-00626-y

  Plantar Heel Pain (PHP) is a common disorder with many treatment pathways and is not self-limiting, hence prognostic information concerning recovery or recalcitrance is needed to guide practice. […] A limited number of biomedical factors predict favourable or unfavourable PHP outcomes. High quality, adequately powered, prospective studies are required to better understand PHP recovery and should evaluate the prognostic value of a wide range of variables, including psychosocial factors. […] The single cohort study by Hansen et al., (2018) revealed that having bilateral heel pain and being female were predictive of a negative prognosis. […] There are limited biomedical factors which can be used to predict PHP outcomes. Having bilateral pain and being female should alert clinicians to an increased risk of a poor outcome. We identified modifiable and measurable factors such as pain status and a variety of ankle and hip kinematics, as being potential factors that predict the success of treatments such as shockwave therapy, anti-pronation taping and foot orthoses. These could assist informed clinical decisions regarding outcome expectations. To better understand PHP recovery or persistence, high quality prospective studies should evaluate the prognostic value of a range of variables, including psychosocial in addition to biological factors.

• #8 Outcome Predictors For Rotator Cuff Tendinopathy

  https://qmro.qmul.ac.uk/xmlui/handle/123456789/79938

  Outcome Predictors For Rotator Cuff Tendinopathy […] Rotator Cuff (RC) tendinopathy is common with a poor recovery rate and unclear prognosis. […] The impact of success would be improved clinical tools to assess and consider prognosis for RC tendinopathy. […] The model demonstrated acceptable accuracy (AUC=0.77) with 76% specificity and 74% sensitivity. […] Lower quality of life, worse night pain, worse unilateral morning stiffness, higher body mass index, higher fear avoidance and higher catastrophising explained 68% of the variance in RC tendinopathy severity (n=82, R2=0.68). […] The recovery rate was 47% occurring mainly around the 7 month follow-up. […] The final model (Chi-square= 9.99 and p= 0.007), including activity (Hazard ratio (95%) = 2.23 (1.084.61)) level and general health status (Hazard ratio (95%) = 1.03 (1.011.05)), partially predicted RC tendinopathy recovery, demonstrating moderate model performance and good internal validation (optimism-corrected Harrell’s C=0.66, calibration slope=0.99).

• #9 Predicting the outcome of plantar heel pain in adults: a systematic review of prognostic factors | Journal of Foot and Ankle Research | Full Text

  https://jfootankleres.biomedcentral.com/articles/10.1186/s13047-023-00626-y

  Plantar Heel Pain (PHP) is a common disorder with many treatment pathways and is not self-limiting, hence prognostic information concerning recovery or recalcitrance is needed to guide practice. […] A limited number of biomedical factors predict favourable or unfavourable PHP outcomes. High quality, adequately powered, prospective studies are required to better understand PHP recovery and should evaluate the prognostic value of a wide range of variables, including psychosocial factors. […] The single cohort study by Hansen et al., (2018) revealed that having bilateral heel pain and being female were predictive of a negative prognosis. […] There are limited biomedical factors which can be used to predict PHP outcomes. Having bilateral pain and being female should alert clinicians to an increased risk of a poor outcome. We identified modifiable and measurable factors such as pain status and a variety of ankle and hip kinematics, as being potential factors that predict the success of treatments such as shockwave therapy, anti-pronation taping and foot orthoses. These could assist informed clinical decisions regarding outcome expectations. To better understand PHP recovery or persistence, high quality prospective studies should evaluate the prognostic value of a range of variables, including psychosocial in addition to biological factors.

• #10 The strength of association between psychological factors and clinical outcome in tendinopathy: A systematic review | PLOS One

  https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0242568

  The overall body of the evidence after applying the GRADE criteria was low to very low certainty evidence, due to risk of bias, imprecision and indirectness found across included studies. […] Future, high quality longitudinal cohort studies are required to investigate the predictive value of baseline psychological factors on long-term clinical outcome. […] The strength of association in the cross-sectional data (r = 0.24 to 0.53) is comparable to other reviews among people with other musculoskeletal conditions. […] In contrast to cross-sectional studies, longitudinal studies can evaluate whether psychological factors predict disease outcome over time. […] The data from the four longitudinal studies were inconsistent for the predictive value of psychological factors on long term clinical outcome.

• #11 The strength of association between psychological factors and clinical outcome in tendinopathy: A systematic review | PLOS One

  https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0242568

  Synthesis of the cross-sectional data revealed low to very low certainty of evidence suggesting weak to moderate strength of association between psychological factors and pain, disability and physical functional outcome in tendinopathy. Importantly, data derived from cross-sectional studies reported similar strengths of association to those found in other common musculoskeletal conditions, such as low back pain. Scarce and conflicting longitudinal data failed to show a predictive relationship between baseline psychological factors and long-term outcome. Hence, larger longitudinal cohort studies are required to investigate the predictive value of psychological factors upon long-term clinical outcome in tendinopathy populations, ensuring studies include people with meaningful levels of pain and psychological distress.

• #12 Outcome Predictors For Rotator Cuff Tendinopathy

  https://qmro.qmul.ac.uk/xmlui/handle/123456789/79938

  Outcome Predictors For Rotator Cuff Tendinopathy […] Rotator Cuff (RC) tendinopathy is common with a poor recovery rate and unclear prognosis. […] The impact of success would be improved clinical tools to assess and consider prognosis for RC tendinopathy. […] The model demonstrated acceptable accuracy (AUC=0.77) with 76% specificity and 74% sensitivity. […] Lower quality of life, worse night pain, worse unilateral morning stiffness, higher body mass index, higher fear avoidance and higher catastrophising explained 68% of the variance in RC tendinopathy severity (n=82, R2=0.68). […] The recovery rate was 47% occurring mainly around the 7 month follow-up. […] The final model (Chi-square= 9.99 and p= 0.007), including activity (Hazard ratio (95%) = 2.23 (1.084.61)) level and general health status (Hazard ratio (95%) = 1.03 (1.011.05)), partially predicted RC tendinopathy recovery, demonstrating moderate model performance and good internal validation (optimism-corrected Harrell’s C=0.66, calibration slope=0.99).

• #13 Outcome Predictors For Rotator Cuff Tendinopathy

  https://qmro.qmul.ac.uk/xmlui/handle/123456789/79938

  Outcome Predictors For Rotator Cuff Tendinopathy […] Rotator Cuff (RC) tendinopathy is common with a poor recovery rate and unclear prognosis. […] The impact of success would be improved clinical tools to assess and consider prognosis for RC tendinopathy. […] The model demonstrated acceptable accuracy (AUC=0.77) with 76% specificity and 74% sensitivity. […] Lower quality of life, worse night pain, worse unilateral morning stiffness, higher body mass index, higher fear avoidance and higher catastrophising explained 68% of the variance in RC tendinopathy severity (n=82, R2=0.68). […] The recovery rate was 47% occurring mainly around the 7 month follow-up. […] The final model (Chi-square= 9.99 and p= 0.007), including activity (Hazard ratio (95%) = 2.23 (1.084.61)) level and general health status (Hazard ratio (95%) = 1.03 (1.011.05)), partially predicted RC tendinopathy recovery, demonstrating moderate model performance and good internal validation (optimism-corrected Harrell’s C=0.66, calibration slope=0.99).

• #14 Prediction of running-induced Achilles tendinopathy with pain sensitivity – a 1-year prospective study

  https://www.degruyterbrill.com/document/doi/10.1515/sjpain-2018-0084/html?srsltid=AfmBOooh6u98JLRcoeygoy6NASoPfOwHFdRP2qUBlUw-WmzjeRANRreJ

  Achilles tendinopathy is common among runners, but the etiology remains unclear. High mechanical pain sensitivity may be a predictor of increased risk of developing Achilles tendinopathy in this group. […] The overall hypothesis was that high pain sensitivity would be related to a higher risk of developing Achilles tendinopathy among recreational male runners. […] No significant association was found between mechanical pain sensitivity in the Achilles tendon and the risk of developing Achilles tendinopathy. However, the risk difference indicated an association between a high mechanical pain sensitivity and an increased risk of developing Achilles tendinopathy. […] Pain sensitivity of the Achilles tendon seems not to be related to an increased risk of developing Achilles pain in relation to running.

• #15 Prediction of running-induced Achilles tendinopathy with pain sensitivity – a 1-year prospective study

  https://www.degruyterbrill.com/document/doi/10.1515/sjpain-2018-0084/html?srsltid=AfmBOooh6u98JLRcoeygoy6NASoPfOwHFdRP2qUBlUw-WmzjeRANRreJ

  With the limitations discussed, this study did not demonstrate a link between mechanical pressure pain sensitivity assessed over the Achilles tendon and an increased risk of Achilles injury in recreational male runners. However, the risk difference indicated an association between a high mechanical pain sensitivity and an increased risk of developing Achilles tendinopathy.

• #16 Prediction of running-induced Achilles tendinopathy with pain sensitivity – a 1-year prospective study

  https://www.degruyter.com/document/doi/10.1515/sjpain-2018-0084/html?lang=en

  Achilles tendinopathy is common among runners, but the etiology remains unclear. High mechanical pain sensitivity may be a predictor of increased risk of developing Achilles tendinopathy in this group. The purpose of this study was to investigate whether local pain sensitivity could predict the development of Achilles tendinopathy in recreational male runners. The overall hypothesis was that high pain sensitivity would be related to a higher risk of developing Achilles tendinopathy among recreational male runners. […] No significant association was found between mechanical pain sensitivity in the Achilles tendon and the risk of developing Achilles tendinopathy. However, the risk difference indicated an association between a high mechanical pain sensitivity and an increased risk of developing Achilles tendinopathy.

• #17 Prediction of running-induced Achilles tendinopathy with pain sensitivity – a 1-year prospective study

  https://www.degruyter.com/document/doi/10.1515/sjpain-2018-0084/html?lang=en

  Pain sensitivity of the Achilles tendon seems not to be related to an increased risk of developing Achilles pain in relation to running. […] With the limitations discussed, this study did not demonstrate a link between mechanical pressure pain sensitivity assessed over the Achilles tendon and an increased risk of Achilles injury in recreational male runners. However, the risk difference indicated an association between a high mechanical pain sensitivity and an increased risk of developing Achilles tendinopathy.

• #18 Outcome Predictors For Rotator Cuff Tendinopathy

  https://qmro.qmul.ac.uk/xmlui/handle/123456789/79938

  Outcome Predictors For Rotator Cuff Tendinopathy […] Rotator Cuff (RC) tendinopathy is common with a poor recovery rate and unclear prognosis. […] The impact of success would be improved clinical tools to assess and consider prognosis for RC tendinopathy. […] The model demonstrated acceptable accuracy (AUC=0.77) with 76% specificity and 74% sensitivity. […] Lower quality of life, worse night pain, worse unilateral morning stiffness, higher body mass index, higher fear avoidance and higher catastrophising explained 68% of the variance in RC tendinopathy severity (n=82, R2=0.68). […] The recovery rate was 47% occurring mainly around the 7 month follow-up. […] The final model (Chi-square= 9.99 and p= 0.007), including activity (Hazard ratio (95%) = 2.23 (1.084.61)) level and general health status (Hazard ratio (95%) = 1.03 (1.011.05)), partially predicted RC tendinopathy recovery, demonstrating moderate model performance and good internal validation (optimism-corrected Harrell’s C=0.66, calibration slope=0.99).

• #19 Outcome Predictors For Rotator Cuff Tendinopathy

  https://qmro.qmul.ac.uk/xmlui/handle/123456789/79938

  Outcome Predictors For Rotator Cuff Tendinopathy […] Rotator Cuff (RC) tendinopathy is common with a poor recovery rate and unclear prognosis. […] The impact of success would be improved clinical tools to assess and consider prognosis for RC tendinopathy. […] The model demonstrated acceptable accuracy (AUC=0.77) with 76% specificity and 74% sensitivity. […] Lower quality of life, worse night pain, worse unilateral morning stiffness, higher body mass index, higher fear avoidance and higher catastrophising explained 68% of the variance in RC tendinopathy severity (n=82, R2=0.68). […] The recovery rate was 47% occurring mainly around the 7 month follow-up. […] The final model (Chi-square= 9.99 and p= 0.007), including activity (Hazard ratio (95%) = 2.23 (1.084.61)) level and general health status (Hazard ratio (95%) = 1.03 (1.011.05)), partially predicted RC tendinopathy recovery, demonstrating moderate model performance and good internal validation (optimism-corrected Harrell’s C=0.66, calibration slope=0.99).

• #20 Outcome Predictors For Rotator Cuff Tendinopathy

  https://qmro.qmul.ac.uk/xmlui/handle/123456789/79938

  Outcome Predictors For Rotator Cuff Tendinopathy […] Rotator Cuff (RC) tendinopathy is common with a poor recovery rate and unclear prognosis. […] The impact of success would be improved clinical tools to assess and consider prognosis for RC tendinopathy. […] The model demonstrated acceptable accuracy (AUC=0.77) with 76% specificity and 74% sensitivity. […] Lower quality of life, worse night pain, worse unilateral morning stiffness, higher body mass index, higher fear avoidance and higher catastrophising explained 68% of the variance in RC tendinopathy severity (n=82, R2=0.68). […] The recovery rate was 47% occurring mainly around the 7 month follow-up. […] The final model (Chi-square= 9.99 and p= 0.007), including activity (Hazard ratio (95%) = 2.23 (1.084.61)) level and general health status (Hazard ratio (95%) = 1.03 (1.011.05)), partially predicted RC tendinopathy recovery, demonstrating moderate model performance and good internal validation (optimism-corrected Harrell’s C=0.66, calibration slope=0.99).

• #21 Outcome Predictors For Rotator Cuff Tendinopathy

  https://qmro.qmul.ac.uk/xmlui/handle/123456789/79938

  Outcome Predictors For Rotator Cuff Tendinopathy […] Rotator Cuff (RC) tendinopathy is common with a poor recovery rate and unclear prognosis. […] The impact of success would be improved clinical tools to assess and consider prognosis for RC tendinopathy. […] The model demonstrated acceptable accuracy (AUC=0.77) with 76% specificity and 74% sensitivity. […] Lower quality of life, worse night pain, worse unilateral morning stiffness, higher body mass index, higher fear avoidance and higher catastrophising explained 68% of the variance in RC tendinopathy severity (n=82, R2=0.68). […] The recovery rate was 47% occurring mainly around the 7 month follow-up. […] The final model (Chi-square= 9.99 and p= 0.007), including activity (Hazard ratio (95%) = 2.23 (1.084.61)) level and general health status (Hazard ratio (95%) = 1.03 (1.011.05)), partially predicted RC tendinopathy recovery, demonstrating moderate model performance and good internal validation (optimism-corrected Harrell’s C=0.66, calibration slope=0.99).

• #22 Classification of distinct tendinopathy subtypes for precision therapeutics | Nature Communications

  https://www.nature.com/articles/s41467-024-53826-w

  Rotator cuff tendinopathy is the most common tendinopathy type with the worst prognosis. […] Conventional treatments often elicit heterogeneous drug responses due to the diversity of tendinopathy. […] Clinical treatment modalities for tendinopathy often elicit heterogeneous responses. […] Glucocorticoid therapy may not improve the prognosis and, in some cases, may even prove to be detrimental. […] Currently, the classification of tendinopathy is primarily based on factors such as onset time, clinical symptoms, and the size and morphology of tear ruptures. […] Commonly utilized one size fits all treatment strategies have resulted in variable therapeutic efficacy among different tendinopathy subtypes. […] Accurately diagnosing and selecting appropriate patients for targeted treatment is expected to improve the current state of tendinopathy therapy.

• #23 Classification of distinct tendinopathy subtypes for precision therapeutics | Nature Communications

  https://www.nature.com/articles/s41467-024-53826-w

  Rotator cuff tendinopathy is the most common tendinopathy type with the worst prognosis. […] Conventional treatments often elicit heterogeneous drug responses due to the diversity of tendinopathy. […] Clinical treatment modalities for tendinopathy often elicit heterogeneous responses. […] Glucocorticoid therapy may not improve the prognosis and, in some cases, may even prove to be detrimental. […] Currently, the classification of tendinopathy is primarily based on factors such as onset time, clinical symptoms, and the size and morphology of tear ruptures. […] Commonly utilized one size fits all treatment strategies have resulted in variable therapeutic efficacy among different tendinopathy subtypes. […] Accurately diagnosing and selecting appropriate patients for targeted treatment is expected to improve the current state of tendinopathy therapy.

• #24 Classification of distinct tendinopathy subtypes for precision therapeutics | Nature Communications

  https://www.nature.com/articles/s41467-024-53826-w

  Rotator cuff tendinopathy is the most common tendinopathy type with the worst prognosis. […] Conventional treatments often elicit heterogeneous drug responses due to the diversity of tendinopathy. […] Clinical treatment modalities for tendinopathy often elicit heterogeneous responses. […] Glucocorticoid therapy may not improve the prognosis and, in some cases, may even prove to be detrimental. […] Currently, the classification of tendinopathy is primarily based on factors such as onset time, clinical symptoms, and the size and morphology of tear ruptures. […] Commonly utilized one size fits all treatment strategies have resulted in variable therapeutic efficacy among different tendinopathy subtypes. […] Accurately diagnosing and selecting appropriate patients for targeted treatment is expected to improve the current state of tendinopathy therapy.

• #25 Classification of distinct tendinopathy subtypes for precision therapeutics | Nature Communications

  https://www.nature.com/articles/s41467-024-53826-w

  The Oxford shoulder score (OSS) in subtype Ir was the lowest, including the total score, and some items of the OSS. […] The shoulder range of motion (ROM) in subtype Ir was the poorest, significantly lower in anteflexion, abduction, and external rotation compared to that in subtype Hw. […] The shoulder joint function of subtype Ir was the worst. […] Our results thus indicate that animal models induced by different mechanisms can to some extent differentially manifest the various characteristics of tendinopathy subtypes. […] Glucocorticoid treatments are more effective in animal models that match the high inflammatory proliferative subtype, leading to enhanced healing of injured tendons. […] This clinical study further confirmed that glucocorticoid therapy was only effective for the high inflammatory proliferative subtype. […] Our results thus indicated that a single pathological mechanism was insufficient to fully explain the complexity of tendinopathy. […] It is anticipated that the one size fits all treatment strategy will eventually shift to a subtype-based treatment approach.

• #26 Classification of distinct tendinopathy subtypes for precision therapeutics | Nature Communications

  https://www.nature.com/articles/s41467-024-53826-w

  The Oxford shoulder score (OSS) in subtype Ir was the lowest, including the total score, and some items of the OSS. […] The shoulder range of motion (ROM) in subtype Ir was the poorest, significantly lower in anteflexion, abduction, and external rotation compared to that in subtype Hw. […] The shoulder joint function of subtype Ir was the worst. […] Our results thus indicate that animal models induced by different mechanisms can to some extent differentially manifest the various characteristics of tendinopathy subtypes. […] Glucocorticoid treatments are more effective in animal models that match the high inflammatory proliferative subtype, leading to enhanced healing of injured tendons. […] This clinical study further confirmed that glucocorticoid therapy was only effective for the high inflammatory proliferative subtype. […] Our results thus indicated that a single pathological mechanism was insufficient to fully explain the complexity of tendinopathy. […] It is anticipated that the one size fits all treatment strategy will eventually shift to a subtype-based treatment approach.

• #27 Classification of distinct tendinopathy subtypes for precision therapeutics | Nature Communications

  https://www.nature.com/articles/s41467-024-53826-w

  The Oxford shoulder score (OSS) in subtype Ir was the lowest, including the total score, and some items of the OSS. […] The shoulder range of motion (ROM) in subtype Ir was the poorest, significantly lower in anteflexion, abduction, and external rotation compared to that in subtype Hw. […] The shoulder joint function of subtype Ir was the worst. […] Our results thus indicate that animal models induced by different mechanisms can to some extent differentially manifest the various characteristics of tendinopathy subtypes. […] Glucocorticoid treatments are more effective in animal models that match the high inflammatory proliferative subtype, leading to enhanced healing of injured tendons. […] This clinical study further confirmed that glucocorticoid therapy was only effective for the high inflammatory proliferative subtype. […] Our results thus indicated that a single pathological mechanism was insufficient to fully explain the complexity of tendinopathy. […] It is anticipated that the one size fits all treatment strategy will eventually shift to a subtype-based treatment approach.

• #28 Classification of distinct tendinopathy subtypes for precision therapeutics | Nature Communications

  https://www.nature.com/articles/s41467-024-53826-w

  Rotator cuff tendinopathy is the most common tendinopathy type with the worst prognosis. […] Conventional treatments often elicit heterogeneous drug responses due to the diversity of tendinopathy. […] Clinical treatment modalities for tendinopathy often elicit heterogeneous responses. […] Glucocorticoid therapy may not improve the prognosis and, in some cases, may even prove to be detrimental. […] Currently, the classification of tendinopathy is primarily based on factors such as onset time, clinical symptoms, and the size and morphology of tear ruptures. […] Commonly utilized one size fits all treatment strategies have resulted in variable therapeutic efficacy among different tendinopathy subtypes. […] Accurately diagnosing and selecting appropriate patients for targeted treatment is expected to improve the current state of tendinopathy therapy.

• #29 Classification of distinct tendinopathy subtypes for precision therapeutics | Nature Communications

  https://www.nature.com/articles/s41467-024-53826-w

  The Oxford shoulder score (OSS) in subtype Ir was the lowest, including the total score, and some items of the OSS. […] The shoulder range of motion (ROM) in subtype Ir was the poorest, significantly lower in anteflexion, abduction, and external rotation compared to that in subtype Hw. […] The shoulder joint function of subtype Ir was the worst. […] Our results thus indicate that animal models induced by different mechanisms can to some extent differentially manifest the various characteristics of tendinopathy subtypes. […] Glucocorticoid treatments are more effective in animal models that match the high inflammatory proliferative subtype, leading to enhanced healing of injured tendons. […] This clinical study further confirmed that glucocorticoid therapy was only effective for the high inflammatory proliferative subtype. […] Our results thus indicated that a single pathological mechanism was insufficient to fully explain the complexity of tendinopathy. […] It is anticipated that the one size fits all treatment strategy will eventually shift to a subtype-based treatment approach.

• #30 Evidence-Based High-Loading Tendon Exercise for 12 Weeks Leads to Increased Tendon Stiffness and Cross-Sectional Area in Achilles Tendinopathy: A Controlled Clinical Trial | Sports Medicine – Open | Full Text

  https://sportsmedicine-open.springeropen.com/articles/10.1186/s40798-022-00545-5

  As hypothesized, by increasing Achilles tendon stiffness and tendon CSA, the high-loading protocol yielded similar responses in male tendinopathic patients as previously observed in male healthy tendons. […] The significant structural and clinical benefits of high-load tendon training are apparent short term and may prolong. […] The high-load exercise protocol significantly improved pain and function in Achilles tendinopathic patients without demonstrating a superior clinical outcome when compared to passive therapy (i.e., the passive therapy group) or Alfredsons protocol. […] Thus, superior structural adaptations such as increased Achilles tendon stiffness and reduced tendon strain did neither directly post-intervention nor 6 months later at follow-up appear to directly translate in a superior reduction in tendinopathy symptoms or an improvement in function (jump performance).

• #31 Evidence-Based High-Loading Tendon Exercise for 12 Weeks Leads to Increased Tendon Stiffness and Cross-Sectional Area in Achilles Tendinopathy: A Controlled Clinical Trial | Sports Medicine – Open | Full Text

  https://sportsmedicine-open.springeropen.com/articles/10.1186/s40798-022-00545-5

  Overall, the magnitude of changes in the triceps surae muscletendon unit of Achilles tendinopathy patients in response to 3 months of home-based high-loading tendon training is comparable to those observed in healthy participants. […] In sum, despite pathological tissue changes, the Achilles tendons of tendinopathy patients benefit in the same way as healthy Achilles tendons from high-loading tendon training. […] Chronic Achilles tendinopathy and the therewith associated pathological changes in tendon structure or metabolism do not seem to impair the Achilles tendons adaptive capacity to respond to intense mechanical loading. […] This high-loading-induced Achilles tendon hypertrophy is likely to have caused the co-occurring increase in tendon stiffness of 20%. […] The increased training-induced tendon stiffness will decrease strain at a given load and may thus contribute to preventing strain-induced (micro)damage and tendon injuries.

• #32 Evidence-Based High-Loading Tendon Exercise for 12 Weeks Leads to Increased Tendon Stiffness and Cross-Sectional Area in Achilles Tendinopathy: A Controlled Clinical Trial | Sports Medicine – Open | Full Text

  https://sportsmedicine-open.springeropen.com/articles/10.1186/s40798-022-00545-5

  Overall, the magnitude of changes in the triceps surae muscletendon unit of Achilles tendinopathy patients in response to 3 months of home-based high-loading tendon training is comparable to those observed in healthy participants. […] In sum, despite pathological tissue changes, the Achilles tendons of tendinopathy patients benefit in the same way as healthy Achilles tendons from high-loading tendon training. […] Chronic Achilles tendinopathy and the therewith associated pathological changes in tendon structure or metabolism do not seem to impair the Achilles tendons adaptive capacity to respond to intense mechanical loading. […] This high-loading-induced Achilles tendon hypertrophy is likely to have caused the co-occurring increase in tendon stiffness of 20%. […] The increased training-induced tendon stiffness will decrease strain at a given load and may thus contribute to preventing strain-induced (micro)damage and tendon injuries.

• #33 Evidence-Based High-Loading Tendon Exercise for 12 Weeks Leads to Increased Tendon Stiffness and Cross-Sectional Area in Achilles Tendinopathy: A Controlled Clinical Trial | Sports Medicine – Open | Full Text

  https://sportsmedicine-open.springeropen.com/articles/10.1186/s40798-022-00545-5

  It has to be considered though that there may be differences in the adaptational response of an adolescent compared to an adult tendon. […] Thus, we recommend the application of high-loading in Achilles tendinopathy patients as an effective (alternative) therapeutic protocol for clinicians and therapists in Achilles tendinopathy rehabilitation management.

• #34 Does Additional Dietary Supplementation Improve Physiotherapeutic Treatment Outcome in Tendinopathy? A Systematic Review and Meta-Analysis

  https://www.mdpi.com/2077-0383/11/6/1666

  A systematic review and meta-analysis of randomized controlled trials was performed to evaluate the effects of dietary supplements in addition to physiotherapeutic treatment on pain and functional outcomes. […] Additional dietary supplementation during physiotherapeutic treatment significantly improved the reduction in pain score (SMD = -0.74, 95% CI, -1.37 to -0.10; p < 0.05), while it had no effect on functional outcomes (SMD = 0.29, 95% CI, 0.00 to 0.58; p > 0.05). This systematic review and meta-analysis suggests that additional nutritional interventions may improve physiotherapeutic treatment outcomes in the management of tendinopathies. […] In the management of tendinopathy, the reduction of pain and the improvement of function are the aims of different treatment methods. […] Our meta-analysis has shown that additional nutritional interventions can reduce pain further than physiotherapy alone, while a significant improvement in function could not be detected.

• #35 Does Additional Dietary Supplementation Improve Physiotherapeutic Treatment Outcome in Tendinopathy? A Systematic Review and Meta-Analysis

  https://www.mdpi.com/2077-0383/11/6/1666

  Despite a reduction in pain, nutritional supplementation during exercise therapy does not seem to further enhance functional outcomes in tendinopathy patients. […] A reduction in pain does not necessarily translate into an improvement in function, which has been reported in various studies. […] In the management of tendinopathy, dietary supplementation in addition to physiotherapeutic treatment may be an effective strategy to reduce pain. However, more high-quality methodology RCTs with a sufficiently large sample size are required to confirm and establish a more definitive conclusion.

• #36 Does Additional Dietary Supplementation Improve Physiotherapeutic Treatment Outcome in Tendinopathy? A Systematic Review and Meta-Analysis

  https://www.mdpi.com/2077-0383/11/6/1666

  Despite a reduction in pain, nutritional supplementation during exercise therapy does not seem to further enhance functional outcomes in tendinopathy patients. […] A reduction in pain does not necessarily translate into an improvement in function, which has been reported in various studies. […] In the management of tendinopathy, dietary supplementation in addition to physiotherapeutic treatment may be an effective strategy to reduce pain. However, more high-quality methodology RCTs with a sufficiently large sample size are required to confirm and establish a more definitive conclusion.

• #37 Classification of distinct tendinopathy subtypes for precision therapeutics | Nature Communications

  https://www.nature.com/articles/s41467-024-53826-w

  Rotator cuff tendinopathy is the most common tendinopathy type with the worst prognosis. […] Conventional treatments often elicit heterogeneous drug responses due to the diversity of tendinopathy. […] Clinical treatment modalities for tendinopathy often elicit heterogeneous responses. […] Glucocorticoid therapy may not improve the prognosis and, in some cases, may even prove to be detrimental. […] Currently, the classification of tendinopathy is primarily based on factors such as onset time, clinical symptoms, and the size and morphology of tear ruptures. […] Commonly utilized one size fits all treatment strategies have resulted in variable therapeutic efficacy among different tendinopathy subtypes. […] Accurately diagnosing and selecting appropriate patients for targeted treatment is expected to improve the current state of tendinopathy therapy.

• #38 Classification of distinct tendinopathy subtypes for precision therapeutics | Nature Communications

  https://www.nature.com/articles/s41467-024-53826-w

  The Oxford shoulder score (OSS) in subtype Ir was the lowest, including the total score, and some items of the OSS. […] The shoulder range of motion (ROM) in subtype Ir was the poorest, significantly lower in anteflexion, abduction, and external rotation compared to that in subtype Hw. […] The shoulder joint function of subtype Ir was the worst. […] Our results thus indicate that animal models induced by different mechanisms can to some extent differentially manifest the various characteristics of tendinopathy subtypes. […] Glucocorticoid treatments are more effective in animal models that match the high inflammatory proliferative subtype, leading to enhanced healing of injured tendons. […] This clinical study further confirmed that glucocorticoid therapy was only effective for the high inflammatory proliferative subtype. […] Our results thus indicated that a single pathological mechanism was insufficient to fully explain the complexity of tendinopathy. […] It is anticipated that the one size fits all treatment strategy will eventually shift to a subtype-based treatment approach.

• #39 ICON 2020—International Scientific Tendinopathy Symposium Consensus: a systematic review of outcome measures reported in clinical trials of Achilles tendinopathy

  https://pmc.ncbi.nlm.nih.gov/articles/PMC8891092/

  233 unique outcome measures for Achilles tendinopathy were identified. […] Most frequently, outcome measures were used within the disability domain. Outcome measures assessing psychological factors were scarcely used. […] The next step in developing a core outcome set for Achilles tendinopathy is to engage patients, clinicians and researchers to reach consensus on key outcomes measures. […] The proportion of studies that included outcomes for core domains ranged from 4% for the psychological factors domain to 72% for the disability domain. […] In fact, aside from disability, all other domains were represented in 45% or less of the studies. […] Commonly used outcome measures are the VISA-A questionnaire (64% of the studies in the disability domain), pain with activity/loading (87% of the studies in the pain on activity/loading domain), patient satisfaction (59% of the studies in the patient overall rating core domain) and pain at follow-up (77% of the studies in the pain over a specified time frame domain). […] The next step in the process of developing this core outcome set is to engage key stakeholders, including patients, clinicians and researchers, to reach consensus regarding the outcome measures (from the measures identified in this review), that should be used in research and practice.

• #40 ICON 2020—International Scientific Tendinopathy Symposium Consensus: a systematic review of outcome measures reported in clinical trials of Achilles tendinopathy

  https://pmc.ncbi.nlm.nih.gov/articles/PMC8891092/

  233 unique outcome measures for Achilles tendinopathy were identified. […] Most frequently, outcome measures were used within the disability domain. Outcome measures assessing psychological factors were scarcely used. […] The next step in developing a core outcome set for Achilles tendinopathy is to engage patients, clinicians and researchers to reach consensus on key outcomes measures. […] The proportion of studies that included outcomes for core domains ranged from 4% for the psychological factors domain to 72% for the disability domain. […] In fact, aside from disability, all other domains were represented in 45% or less of the studies. […] Commonly used outcome measures are the VISA-A questionnaire (64% of the studies in the disability domain), pain with activity/loading (87% of the studies in the pain on activity/loading domain), patient satisfaction (59% of the studies in the patient overall rating core domain) and pain at follow-up (77% of the studies in the pain over a specified time frame domain). […] The next step in the process of developing this core outcome set is to engage key stakeholders, including patients, clinicians and researchers, to reach consensus regarding the outcome measures (from the measures identified in this review), that should be used in research and practice.

• #41 ICON 2020—International Scientific Tendinopathy Symposium Consensus: a systematic review of outcome measures reported in clinical trials of Achilles tendinopathy

  https://pmc.ncbi.nlm.nih.gov/articles/PMC8891092/

  233 unique outcome measures for Achilles tendinopathy were identified. […] Most frequently, outcome measures were used within the disability domain. Outcome measures assessing psychological factors were scarcely used. […] The next step in developing a core outcome set for Achilles tendinopathy is to engage patients, clinicians and researchers to reach consensus on key outcomes measures. […] The proportion of studies that included outcomes for core domains ranged from 4% for the psychological factors domain to 72% for the disability domain. […] In fact, aside from disability, all other domains were represented in 45% or less of the studies. […] Commonly used outcome measures are the VISA-A questionnaire (64% of the studies in the disability domain), pain with activity/loading (87% of the studies in the pain on activity/loading domain), patient satisfaction (59% of the studies in the patient overall rating core domain) and pain at follow-up (77% of the studies in the pain over a specified time frame domain). […] The next step in the process of developing this core outcome set is to engage key stakeholders, including patients, clinicians and researchers, to reach consensus regarding the outcome measures (from the measures identified in this review), that should be used in research and practice.

• #42 ICON 2020—International Scientific Tendinopathy Symposium Consensus: a systematic review of outcome measures reported in clinical trials of Achilles tendinopathy

  https://pmc.ncbi.nlm.nih.gov/articles/PMC8891092/

  233 unique outcome measures for Achilles tendinopathy were identified. […] Most frequently, outcome measures were used within the disability domain. Outcome measures assessing psychological factors were scarcely used. […] The next step in developing a core outcome set for Achilles tendinopathy is to engage patients, clinicians and researchers to reach consensus on key outcomes measures. […] The proportion of studies that included outcomes for core domains ranged from 4% for the psychological factors domain to 72% for the disability domain. […] In fact, aside from disability, all other domains were represented in 45% or less of the studies. […] Commonly used outcome measures are the VISA-A questionnaire (64% of the studies in the disability domain), pain with activity/loading (87% of the studies in the pain on activity/loading domain), patient satisfaction (59% of the studies in the patient overall rating core domain) and pain at follow-up (77% of the studies in the pain over a specified time frame domain). […] The next step in the process of developing this core outcome set is to engage key stakeholders, including patients, clinicians and researchers, to reach consensus regarding the outcome measures (from the measures identified in this review), that should be used in research and practice.

• #43 ICON 2020—International Scientific Tendinopathy Symposium Consensus: a systematic review of outcome measures reported in clinical trials of Achilles tendinopathy

  https://pmc.ncbi.nlm.nih.gov/articles/PMC8891092/

  233 unique outcome measures for Achilles tendinopathy were identified. […] Most frequently, outcome measures were used within the disability domain. Outcome measures assessing psychological factors were scarcely used. […] The next step in developing a core outcome set for Achilles tendinopathy is to engage patients, clinicians and researchers to reach consensus on key outcomes measures. […] The proportion of studies that included outcomes for core domains ranged from 4% for the psychological factors domain to 72% for the disability domain. […] In fact, aside from disability, all other domains were represented in 45% or less of the studies. […] Commonly used outcome measures are the VISA-A questionnaire (64% of the studies in the disability domain), pain with activity/loading (87% of the studies in the pain on activity/loading domain), patient satisfaction (59% of the studies in the patient overall rating core domain) and pain at follow-up (77% of the studies in the pain over a specified time frame domain). […] The next step in the process of developing this core outcome set is to engage key stakeholders, including patients, clinicians and researchers, to reach consensus regarding the outcome measures (from the measures identified in this review), that should be used in research and practice.

• #44 ICON 2019—International Scientific Tendinopathy Symposium Consensus: There are nine core health-related domains for tendinopathy (CORE DOMAINS): Delphi study of healthcare professionals and patients | British Journal of Sports Medicine

  https://bjsm.bmj.com/content/54/8/444

  Nine core domains for tendon research should guide reporting of outcomes in clinical trials. […] The nine core domains reflect how HCPs and patients understand the nature of tendinopathy. […] The next stage will be for HCP with relevant expertise and patients with tendinopathies to establish the core outcome measures (ie, core outcome sets) that align with each of the core domains for the different regional tendinopathies. […] Clinical trials should include a measure for each of the nine core domains at a minimum, so that future meta-analyses will be able to better estimate treatment effects. […] The agreed core domains should not prevent the use of other outcomes in trials or clinical practice. The nine core domains represent the minimal reporting requirement.

• #45 ICON 2019—International Scientific Tendinopathy Symposium Consensus: There are nine core health-related domains for tendinopathy (CORE DOMAINS): Delphi study of healthcare professionals and patients | British Journal of Sports Medicine

  https://bjsm.bmj.com/content/54/8/444

  Nine core domains for tendon research should guide reporting of outcomes in clinical trials. […] The nine core domains reflect how HCPs and patients understand the nature of tendinopathy. […] The next stage will be for HCP with relevant expertise and patients with tendinopathies to establish the core outcome measures (ie, core outcome sets) that align with each of the core domains for the different regional tendinopathies. […] Clinical trials should include a measure for each of the nine core domains at a minimum, so that future meta-analyses will be able to better estimate treatment effects. […] The agreed core domains should not prevent the use of other outcomes in trials or clinical practice. The nine core domains represent the minimal reporting requirement.

• #46 ICON 2019—International Scientific Tendinopathy Symposium Consensus: There are nine core health-related domains for tendinopathy (CORE DOMAINS): Delphi study of healthcare professionals and patients | British Journal of Sports Medicine

  https://bjsm.bmj.com/content/54/8/444

  Nine core domains for tendon research should guide reporting of outcomes in clinical trials. […] The nine core domains reflect how HCPs and patients understand the nature of tendinopathy. […] The next stage will be for HCP with relevant expertise and patients with tendinopathies to establish the core outcome measures (ie, core outcome sets) that align with each of the core domains for the different regional tendinopathies. […] Clinical trials should include a measure for each of the nine core domains at a minimum, so that future meta-analyses will be able to better estimate treatment effects. […] The agreed core domains should not prevent the use of other outcomes in trials or clinical practice. The nine core domains represent the minimal reporting requirement.

• #47 Assessing Patient-Centred Outcomes in Lateral Elbow Tendinopathy: A Systematic Review and Standardised Comparison of English Language Clinical Rating Systems | Sports Medicine – Open | Full Text

  https://sportsmedicine-open.springeropen.com/articles/10.1186/s40798-019-0183-2

  This is the first study to provide standardised guidance on the choice of measures for LET. […] Robust evidence is available for four measures, the DASH, QDASH, PRTEE and OES. […] The use of instruments in the literature is only in part explained by instrument performance. […] Adequate evidence of their validity is only available for four of those 15 clinical ratings systems. […] Within the literature, the choice of the clinical rating system has not been associated with its quality. […] The overall summary scores ranged from 72.5 (qDASH) to 21.6 (ASES-E). […] Only four instruments met the threshold score of 50/100: one LET specific (PRTEE), one elbow specific (OES) and two upper-limb specific (qDASH and DASH). […] This study has gone a step further than previous elbow-specific outcome instrument evaluations in attempting to systematically compare the instruments in a condition-specific context.

• #48 Assessing Patient-Centred Outcomes in Lateral Elbow Tendinopathy: A Systematic Review and Standardised Comparison of English Language Clinical Rating Systems | Sports Medicine – Open | Full Text

  https://sportsmedicine-open.springeropen.com/articles/10.1186/s40798-019-0183-2

  This is the first study to provide standardised guidance on the choice of measures for LET. […] Robust evidence is available for four measures, the DASH, QDASH, PRTEE and OES. […] The use of instruments in the literature is only in part explained by instrument performance. […] Adequate evidence of their validity is only available for four of those 15 clinical ratings systems. […] Within the literature, the choice of the clinical rating system has not been associated with its quality. […] The overall summary scores ranged from 72.5 (qDASH) to 21.6 (ASES-E). […] Only four instruments met the threshold score of 50/100: one LET specific (PRTEE), one elbow specific (OES) and two upper-limb specific (qDASH and DASH). […] This study has gone a step further than previous elbow-specific outcome instrument evaluations in attempting to systematically compare the instruments in a condition-specific context.

• #49 Assessing Patient-Centred Outcomes in Lateral Elbow Tendinopathy: A Systematic Review and Standardised Comparison of English Language Clinical Rating Systems | Sports Medicine – Open | Full Text

  https://sportsmedicine-open.springeropen.com/articles/10.1186/s40798-019-0183-2

  This is the first study to provide standardised guidance on the choice of measures for LET. […] Robust evidence is available for four measures, the DASH, QDASH, PRTEE and OES. […] The use of instruments in the literature is only in part explained by instrument performance. […] Adequate evidence of their validity is only available for four of those 15 clinical ratings systems. […] Within the literature, the choice of the clinical rating system has not been associated with its quality. […] The overall summary scores ranged from 72.5 (qDASH) to 21.6 (ASES-E). […] Only four instruments met the threshold score of 50/100: one LET specific (PRTEE), one elbow specific (OES) and two upper-limb specific (qDASH and DASH). […] This study has gone a step further than previous elbow-specific outcome instrument evaluations in attempting to systematically compare the instruments in a condition-specific context.

• #50 Assessing Patient-Centred Outcomes in Lateral Elbow Tendinopathy: A Systematic Review and Standardised Comparison of English Language Clinical Rating Systems | Sports Medicine – Open | Full Text

  https://sportsmedicine-open.springeropen.com/articles/10.1186/s40798-019-0183-2

  We would recommend authors of future studies of LET participants, where English language instruments will be used, consider the qDASH, DASH, OES or PRTEE. […] Future instrument development, particularly for those not meeting the recommended standards, can also be rationalised from the presented evidence.

• #51 How to diagnose plantaris tendon involvement in midportion Achilles tendinopathy – clinical and imaging findings | BMC Musculoskeletal Disorders | Full Text

  https://bmcmusculoskeletdisord.biomedcentral.com/articles/10.1186/s12891-016-0955-5

  US+CD directly, and clinical assessment indirectly, can detect a close by located plantaris tendon in a high proportion of patients with midportion Achilles tendinopathy. […] The plantaris tendon is increasingly recognised as an important factor in midportion Achilles tendinopathy. […] Tendon tenderness and pain are considered relatively non-specific findings; however, the localisation of pain and tenderness at the medial Achilles tendon could be an important clinical marker of plantaris tendon involvement in midportion Achilles tendinopathy and may warrant further investigation. […] For US+CD, a majority of tendons revealed an obvious tendon-like structure that made the diagnosis of a plantaris tendon involvement relatively straightforward. […] These changes may represent an indirect sign of plantaris tendon involvement via compression of the plantaris on the medial aspect of the Achilles tendon.

• #52 How to diagnose plantaris tendon involvement in midportion Achilles tendinopathy – clinical and imaging findings | BMC Musculoskeletal Disorders | Full Text

  https://bmcmusculoskeletdisord.biomedcentral.com/articles/10.1186/s12891-016-0955-5

  US+CD directly, and clinical assessment indirectly, can detect a close by located plantaris tendon in a high proportion of patients with midportion Achilles tendinopathy. […] The plantaris tendon is increasingly recognised as an important factor in midportion Achilles tendinopathy. […] Tendon tenderness and pain are considered relatively non-specific findings; however, the localisation of pain and tenderness at the medial Achilles tendon could be an important clinical marker of plantaris tendon involvement in midportion Achilles tendinopathy and may warrant further investigation. […] For US+CD, a majority of tendons revealed an obvious tendon-like structure that made the diagnosis of a plantaris tendon involvement relatively straightforward. […] These changes may represent an indirect sign of plantaris tendon involvement via compression of the plantaris on the medial aspect of the Achilles tendon.

• #53 How to diagnose plantaris tendon involvement in midportion Achilles tendinopathy – clinical and imaging findings | BMC Musculoskeletal Disorders | Full Text

  https://bmcmusculoskeletdisord.biomedcentral.com/articles/10.1186/s12891-016-0955-5

  US+CD directly, and clinical assessment indirectly, can detect a close by located plantaris tendon in a high proportion of patients with midportion Achilles tendinopathy. […] The plantaris tendon is increasingly recognised as an important factor in midportion Achilles tendinopathy. […] Tendon tenderness and pain are considered relatively non-specific findings; however, the localisation of pain and tenderness at the medial Achilles tendon could be an important clinical marker of plantaris tendon involvement in midportion Achilles tendinopathy and may warrant further investigation. […] For US+CD, a majority of tendons revealed an obvious tendon-like structure that made the diagnosis of a plantaris tendon involvement relatively straightforward. […] These changes may represent an indirect sign of plantaris tendon involvement via compression of the plantaris on the medial aspect of the Achilles tendon.

• #54 How to diagnose plantaris tendon involvement in midportion Achilles tendinopathy – clinical and imaging findings | BMC Musculoskeletal Disorders | Full Text

  https://bmcmusculoskeletdisord.biomedcentral.com/articles/10.1186/s12891-016-0955-5

  In conclusion, in patients with midportion Achilles tendinopathy, medial tenderness and activity related medial pain might indicate plantaris tendon involvement. US+CD can directly visualise the plantaris tendon in a high proportion of the patients, and UTC seems to have potential to indirectly detect a plantaris tendon located close to the medial Achilles in a majority of the patients. While not essential in diagnosing plantaris involvement, UTC may complement clinical assessment and US+CD in confirming plantaris-involvement, which may significantly change clinical management in patients with mid-portion Achilles tendinopathy.

• #55 Classification of distinct tendinopathy subtypes for precision therapeutics | Nature Communications

  https://www.nature.com/articles/s41467-024-53826-w

  Rotator cuff tendinopathy is the most common tendinopathy type with the worst prognosis. […] Conventional treatments often elicit heterogeneous drug responses due to the diversity of tendinopathy. […] Clinical treatment modalities for tendinopathy often elicit heterogeneous responses. […] Glucocorticoid therapy may not improve the prognosis and, in some cases, may even prove to be detrimental. […] Currently, the classification of tendinopathy is primarily based on factors such as onset time, clinical symptoms, and the size and morphology of tear ruptures. […] Commonly utilized one size fits all treatment strategies have resulted in variable therapeutic efficacy among different tendinopathy subtypes. […] Accurately diagnosing and selecting appropriate patients for targeted treatment is expected to improve the current state of tendinopathy therapy.

• #56 Classification of distinct tendinopathy subtypes for precision therapeutics | Nature Communications

  https://www.nature.com/articles/s41467-024-53826-w

  The Oxford shoulder score (OSS) in subtype Ir was the lowest, including the total score, and some items of the OSS. […] The shoulder range of motion (ROM) in subtype Ir was the poorest, significantly lower in anteflexion, abduction, and external rotation compared to that in subtype Hw. […] The shoulder joint function of subtype Ir was the worst. […] Our results thus indicate that animal models induced by different mechanisms can to some extent differentially manifest the various characteristics of tendinopathy subtypes. […] Glucocorticoid treatments are more effective in animal models that match the high inflammatory proliferative subtype, leading to enhanced healing of injured tendons. […] This clinical study further confirmed that glucocorticoid therapy was only effective for the high inflammatory proliferative subtype. […] Our results thus indicated that a single pathological mechanism was insufficient to fully explain the complexity of tendinopathy. […] It is anticipated that the one size fits all treatment strategy will eventually shift to a subtype-based treatment approach.

• #57 Outcome Predictors For Rotator Cuff Tendinopathy

  https://qmro.qmul.ac.uk/xmlui/handle/123456789/79938

  A promising remote ScDys method and graded loaded challenge have been developed and further merit clinical evaluation. […] Both factors could be important constructs to measure at initial assessment as they partially predicted recovery and were easily collected. […] Our explanatory models should improve clinicians understanding of RC tendinopathy profile and prognosis, and practice change may be confidently recommended after external model validation.

• #58 Evidence-Based High-Loading Tendon Exercise for 12 Weeks Leads to Increased Tendon Stiffness and Cross-Sectional Area in Achilles Tendinopathy: A Controlled Clinical Trial | Sports Medicine – Open | Full Text

  https://sportsmedicine-open.springeropen.com/articles/10.1186/s40798-022-00545-5

  It has to be considered though that there may be differences in the adaptational response of an adolescent compared to an adult tendon. […] Thus, we recommend the application of high-loading in Achilles tendinopathy patients as an effective (alternative) therapeutic protocol for clinicians and therapists in Achilles tendinopathy rehabilitation management.

• #59 The strength of association between psychological factors and clinical outcome in tendinopathy: A systematic review | PLOS One

  https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0242568

  Synthesis of the cross-sectional data revealed low to very low certainty of evidence suggesting weak to moderate strength of association between psychological factors and pain, disability and physical functional outcome in tendinopathy. Importantly, data derived from cross-sectional studies reported similar strengths of association to those found in other common musculoskeletal conditions, such as low back pain. Scarce and conflicting longitudinal data failed to show a predictive relationship between baseline psychological factors and long-term outcome. Hence, larger longitudinal cohort studies are required to investigate the predictive value of psychological factors upon long-term clinical outcome in tendinopathy populations, ensuring studies include people with meaningful levels of pain and psychological distress.

• #60 Classification of distinct tendinopathy subtypes for precision therapeutics | Nature Communications

  https://www.nature.com/articles/s41467-024-53826-w

  The Oxford shoulder score (OSS) in subtype Ir was the lowest, including the total score, and some items of the OSS. […] The shoulder range of motion (ROM) in subtype Ir was the poorest, significantly lower in anteflexion, abduction, and external rotation compared to that in subtype Hw. […] The shoulder joint function of subtype Ir was the worst. […] Our results thus indicate that animal models induced by different mechanisms can to some extent differentially manifest the various characteristics of tendinopathy subtypes. […] Glucocorticoid treatments are more effective in animal models that match the high inflammatory proliferative subtype, leading to enhanced healing of injured tendons. […] This clinical study further confirmed that glucocorticoid therapy was only effective for the high inflammatory proliferative subtype. […] Our results thus indicated that a single pathological mechanism was insufficient to fully explain the complexity of tendinopathy. […] It is anticipated that the one size fits all treatment strategy will eventually shift to a subtype-based treatment approach.

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