Materiały źródłowe

• #1 Nasal Polyps: Symptoms, Causes, Treatment & Removal

  https://my.clevelandclinic.org/health/diseases/15250-nasal-polyps

  Nasal polyp treatment depends on the severity of your condition. Medication and surgery are the two main approaches. […] Even with surgical removal, nasal polyps may grow back over time. Your healthcare provider will talk to you about the likelihood of recurrence (return) and how you can manage it. […] Medication usually doesn’t get rid of nasal polyps, but it can ease symptoms. Common treatments include: […] Steroid nasal sprays to shrink polyps and improve symptoms. […] Oral steroids (pills you swallow) like prednisone. […] Biologic medications, such as dupilumab injections. (Dupilumab contains monoclonal antibodies that stimulate your immune system and may shrink nasal polyps.) […] If medication doesn’t work or if you have large polyps you may need sinus surgery to remove them. Your provider may use nasal endoscopy to do one of these minimally invasive procedures:

• #2 Nasal polyps – Symptoms and causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/nasal-polyps/symptoms-causes/syc-20351888

  Nasal polyps can affect anyone. But they’re more common in young and middle-aged adults. Medicines can often shrink nasal polyps or get rid of them. But surgery might be needed to remove them. Even after treatment, nasal polyps often come back. […] Use a nasal rinse. Rinsing the inside of the nose with a saltwater spray or nasal wash might help remove what irritates it. You can buy saltwater sprays and nasal wash kits without a prescription. Nasal wash kits come with a neti pot or squeeze bottle and directions for how to use them.

• #3 Get Nasal Polyps Treatment | Cleveland Clinic

  https://my.clevelandclinic.org/services/nasal-polyps-treatment

  We offer personalized treatment plans to care for your nasal polyps and help relieve your symptoms. […] For some people, medication can shrink nasal polyps and get you back to smelling, sleeping and breathing easily. […] Your treatment may begin with antibiotics, steroid nasal sprays or steroid pills. […] Your team may also recommend injection (shot) therapy of an anti-inflammatory medication called dupilumab, which helps to control congestion and shrink nasal polyps. […] If medication doesn’t do the trick, your provider may recommend surgery. […] Even after surgery or with medication, nasal polyps can be stubborn, and it’s common for them to come back. […] Your team will help you manage them.

• #4 Nasal Polyps – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK560746/

  Nasal polyps are benign, inflammatory outgrowths of the sinonasal mucosa that can lead to chronic nasal obstruction, congestion, and diminished quality of life. […] Management strategies range from medical therapies, such as intranasal corticosteroids, saline irrigation, and biologics, to surgical intervention in refractory cases. Endoscopic sinus surgery may be necessary for symptom relief and restoration of nasal airflow. […] For patients with CRSwNP, initial therapy with intranasal corticosteroids and nasal saline irrigations for approximately 2 to 3 months should be attempted. High-volume, low-pressure nasal saline irrigations are a safe and inexpensive method that increases the clearance of antigens, biofilms, and inflammatory mediators. Intranasal corticosteroids help alleviate nasal congestion and reduce polyp size.

• #5 Nasal Polyps

  https://www.aaaai.org/tools-for-the-public/conditions-library/allergies/nasal-polyps

  Medical treatment of CRSwNP includes both topical nasal steroid sprays and nasal saline rinses. Steroid sprays help reduce polyp size and improve symptoms and are very safe for long-term use. Short courses of oral steroids can also help shrink nasal polyps and have shown to improve symptoms including sense of smell, however they should be used cautiously given the risk of steroid side effects. […] Sinus surgery to remove polyps is an option if nasal polyps are bothersome despite oral and/or corticosteroid sprays. Unfortunately, polyps often recur despite surgery and long-term treatment with nasal steroids or large volume steroids are often necessary. […] More recently, different steroid delivery options have been utilized for treatment of CRSwNP. Large volume nasal steroid rinses with squeeze plastic bottles have been shown to be superior to traditional steroid sprays. Exhalation delivery system with fluticasone is a recently approved steroid device that sprays fluticasone deeper into the nasal cavity to reduce inflammation from nasal polyps. Stents that deliver topical steroids can also be inserted by surgeons and have shown benefit in reducing polyp recurrence. Other medications that have shown some benefit in the treatment of nasal polyps include leukotriene inhibitors such as montelukast. Additionally, antibiotics are occasionally prescribed if there is a concern for infection although there is not much scientific evidence for their efficacy. Finally, biologic medications (dupilumab, mepolizumab and omalizumab), which have been approved to treat moderate to severe asthma, have also gained approval to treat CRSwNP. These are given as injections every 2-4 weeks and have been shown to reduce the need for surgery and treatment with oral steroids.

• #6 What is Chronic Rhinosinusitis with Nasal Polyps (CRSwNP)? – Allergy & Asthma Network

  https://allergyasthmanetwork.org/health-a-z/chronic-rhinosinusitis-with-nasal-polyps-crswnp/

  Chronic rhinosinusitis with nasal polyps treatment focuses on both the sinus symptoms and the nasal polyps. Corticosteroid nasal sprays are considered the first line of treatment. […] Corticosteroid nasal sprays: these are designed to reduce inflammation and swelling in the nasal passages. Over-the-counter and prescription versions are available. Mometasone is commonly prescribed corticosteroid nasal spray that is indicated for the treatment of nasal polyps. […] Fluticasone with Exhalation Delivery System (EDS): this corticosteroid medication treats nasal polyps as well as common allergy symptoms such as runny nose or sneezing. […] Short course of oral corticosteroids: these can help shrink nasal polyps. However, they should be used with caution. Long-term use of oral corticosteroids can cause severe side effects.

• #7 Nasal Polyps – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK560746/

  When CRSwNP is refractory to adequate medical treatment, functional endoscopic sinus surgery (FESS) is planned. […] Topical intranasal steroids form an essential part of CRSwNP treatment postoperatively. […] Continuing nasal saline irrigations and intranasal corticosteroids after surgery improves the likelihood of long-term success. […] If a patient remains symptomatic despite the strategies above, oral corticosteroids may be used. […] Biologic drugs, such as monoclonal antibodies, may be considered for patients with refractory disease. […] Treatment of the underlying condition is essential for patients with a systemic disease associated with nasal polyps, such as EGPA or cystic fibrosis. […] Intranasal corticosteroids, such as budesonide, fluticasone propionate, and mometasone furoate, effectively reduce polyp size.

• #8

  https://med.uth.edu/orl/2020/02/16/new-nonsurgical-treatments-for-nasal-polyps-help-patients-breathe-again/

  The exhalation delivery system includes a nosepiece patients put in their nostril and a flexible mouthpiece. As they blow into the mouthpiece, the exhalation pushes the steroid high and deep into the nasal passages, where polyps occur. […] Dr. Citardi adds, Mr. Toufeeq has done very well with exhalation delivery of steroids. We are now fortunate to have other alternatives to standard endoscopic sinus surgery for patients who are reluctant to undergo surgery. For this reason, we can be more selective in choosing what works best for each patient.

• #9 What is Chronic Rhinosinusitis with Nasal Polyps (CRSwNP)? – Allergy & Asthma Network

  https://allergyasthmanetwork.org/health-a-z/chronic-rhinosinusitis-with-nasal-polyps-crswnp/

  Chronic rhinosinusitis with nasal polyps treatment focuses on both the sinus symptoms and the nasal polyps. Corticosteroid nasal sprays are considered the first line of treatment. […] Corticosteroid nasal sprays: these are designed to reduce inflammation and swelling in the nasal passages. Over-the-counter and prescription versions are available. Mometasone is commonly prescribed corticosteroid nasal spray that is indicated for the treatment of nasal polyps. […] Fluticasone with Exhalation Delivery System (EDS): this corticosteroid medication treats nasal polyps as well as common allergy symptoms such as runny nose or sneezing. […] Short course of oral corticosteroids: these can help shrink nasal polyps. However, they should be used with caution. Long-term use of oral corticosteroids can cause severe side effects.

• #10 What Medications Treat Nasal Polyps?

  https://www.webmd.com/allergies/features/nasal-polyps-meds

  Many people use them along with other treatments. Research shows that combining topical and oral steroids is more effective to shrink polyps and improve your sense of smell than topical steroids alone. […] Oral steroids: Oral steroids are among the most common treatments for nasal polyps. Doctors may prescribe them: When you have serious sinus disease, If your nasal polyps tend to come back, When sprays don’t work to shrink your polyps or reduce symptoms. […] Because of the risk of side effects, your doctor probably won’t recommend using oral steroids long term. Their effects usually last for a few months. […] Injectable steroids: Your doctor can inject steroid medication directly into nasal polyps, which helps more medication reach the site. The effects of injectable steroids should last for at least 3 months.

• #11 Nasal polyps

  https://www.nhs.uk/conditions/nasal-polyps/

  If you have nasal polyps, you’ll usually be given steroid nose drops or a spray to shrink the polyps. […] Sometimes, you may be given steroid tablets, usually for up to 2 weeks, to help relieve symptoms. […] If there’s no sign of improvement after about 12 weeks, the GP may suggest surgery to remove your polyps. […] Most people who have surgery see an improvement, but it’s common for polyps to grow back, usually within a few years. […] You may need to keep using a steroid nasal spray after surgery to stop the polyps returning quickly.

• #12 What Medications Treat Nasal Polyps?

  https://www.webmd.com/allergies/features/nasal-polyps-meds

  Many people use them along with other treatments. Research shows that combining topical and oral steroids is more effective to shrink polyps and improve your sense of smell than topical steroids alone. […] Oral steroids: Oral steroids are among the most common treatments for nasal polyps. Doctors may prescribe them: When you have serious sinus disease, If your nasal polyps tend to come back, When sprays don’t work to shrink your polyps or reduce symptoms. […] Because of the risk of side effects, your doctor probably won’t recommend using oral steroids long term. Their effects usually last for a few months. […] Injectable steroids: Your doctor can inject steroid medication directly into nasal polyps, which helps more medication reach the site. The effects of injectable steroids should last for at least 3 months.

• #13 Nonsurgical Treatment of Nasal Polyps: Practice Essentials, Pathophysiology, Epidemiology

  https://emedicine.medscape.com/article/861353-overview

  Nasal polyposis is an inflammatory condition of unknown etiology. Oral corticosteroids are the most effective short-term medical treatment for nasal polyps. […] These nonspecific anti-inflammatory agents quickly and substantially reduce the size of inflammatory polyps and improve symptoms. […] In June 2019, the US Food and Drug Administration (FDA) approved the monoclonal antibody dupilumab for treatment in adults with inadequately controlled, severe chronic rhinosinusitis with nasal polyps (CRSwNP). The monoclonal antibodies omalizumab and mepolizumab subsequently received FDA approval for use against CRSwNP, again for adult patients in whom the condition is inadequately controlled.

• #14 FDA approves first treatment for chronic rhinosinusitis with nasal polyps | FDA

  https://www.fda.gov/news-events/press-announcements/fda-approves-first-treatment-chronic-rhinosinusitis-nasal-polyps

  The U.S. Food and Drug Administration today approved Dupixent (dupilumab) to treat adults with nasal polyps (growths on the inner lining of the sinuses) accompanied by chronic rhinosinusitis (prolonged inflammation of the sinuses and nasal cavity). This is the first treatment approved for inadequately controlled chronic rhinosinusis with nasal polyps. […] Dupixent provides an important treatment option for patients whose nasal polyps are not adequately controlled with intranasal steroids. It also reduces the need for nasal polyp surgery and oral steroids. […] Patients who received Dupixent had statistically significant reductions in their nasal polyp size and nasal congestion compared to the placebo group. Patients taking Dupixent also reported an increased ability to smell and required less nasal polyp surgery and oral steroids.

• #15 DUPIXENT® (dupilumab) in Adults with Nasal Polyps

  https://www.dupixent.com/crswnp/

  DUPIXENT is used with other medicines for the maintenance treatment of chronic rhinosinusitis with nasal polyps (CRSwNP) in adults and children 12 years of age and older whose disease is not controlled. […] DUPIXENT treats an underlying cause of nasal polyps and can reduce the need for surgery. […] DUPIXENT targets two of the key sources of inflammation in nasal polyps. DUPIXENT can help improve nasal congestion and sense of smell in as little as 3 days.

• #16 Nasal polyps: Tiny lumps pack a punch – Mayo Clinic Health System

  https://www.mayoclinichealthsystem.org/hometown-health/speaking-of-health/nasal-polyps-pack-a-punch

  Nasal polyps can cause complications because they block airflow, fluid drainage and long-term inflammation underlying their development. In some people, they cause worsening asthma or structural changes in the sinuses. […] The treatment goal for nasal polyps is to reduce their size or eliminate them. Medication usually is the first approach. Surgery sometimes may be needed, but it may not provide a permanent solution because polyps tend to recur. […] Nasal steroids and budesonide rinses may reduce swelling and irritation. These treatments may shrink polyps or eliminate them completely. […] If you have nasal polyps and chronic sinusitis, your healthcare team may give you an injection of a medication called dupilumab, commonly known as Dupixent, to treat your condition. This biologic medication may reduce the size of the nasal polyps and lessen congestion. It’s often prescribed by an allergist and can be administered at home. […] Nasal polyps in children typically are treated with topical medications and dupilumab.

• #17 Chronic Rhinosinusitis With Nasal Polyps – ACAAI Patient

  https://acaai.org/allergies/allergic-conditions/chronic-rhinosinusitis-with-nasal-polyps/

  Dupixent®, which you inject yourself every two weeks […] Xolair®, which is injected by the allergist or at home after the first three doses in the physician’s office, every two to four weeks. […] You may get permanent relief using medications or having your polyps surgically removed. In many cases, though, the polyps – and the frustrating symptoms – come back. Your allergist or ENT specialist will work with you to determine what treatment to try next, including different medications or first-time or repeat surgery. […] There is an additional treatment that is only available to people who have had nasal polyps return after surgery. It involves placing tiny, corticosteroid-coated implants (Sinuva®) in your sinuses. These implants, called stents, slowly release the medication and dissolve over several weeks. The procedure can be performed in the ENT’s office. The benefits of the implants last several months, and the doctor may recommend you continue using a corticosteroid nasal spray and/or saline rinse or spray. You may need the implant procedure again once the benefits wear off.

• #18 Biologics for Chronic Rhinosinusitis with Nasal Polyps | AAO-HNS Bulletin

  https://bulletin.entnet.org/clinical-patient-care/article/22881642/biologics-for-chronic-rhinosinusitis-with-nasal-polyps

  Chronic rhinosinusitis with nasal polyps (CRSwNP) is generally considered to be driven by a predominant type 2 pattern of inflammation in the United States and the Western world; however, it is possible that more than one type of inflammation (e.g., type 1, type 2, and type 3) may coexist in the individual patient. […] The contemporary standard of care in treating CRSwNP includes therapeutics modulating or decreasing the inflammatory response in the sinonasal mucosa, with endoscopic sinus surgery (ESS) recommended for patients refractory to optimal medical therapy. Optimal medical therapy for CRSwNP as recommended by consensus guidelines includes high-volume saline rinse and topical nasal steroids with or without short courses of systemic corticosteroids. […] Biologics are monoclonal antibodies developed through recombinant technology. They act by targeting a specific protein considered germane in the pathogenesis of a disease. Three biologics targeting type 2 inflammation in CRSwNP have recently been approved by the U.S. Food and Drugs Administration (FDA): dupilumab, mepolizumab, and omalizumab.

• #19 Biologics for Chronic Rhinosinusitis with Nasal Polyps | AAO-HNS Bulletin

  https://bulletin.entnet.org/clinical-patient-care/article/22881642/biologics-for-chronic-rhinosinusitis-with-nasal-polyps

  Chronic rhinosinusitis with nasal polyps (CRSwNP) is generally considered to be driven by a predominant type 2 pattern of inflammation in the United States and the Western world; however, it is possible that more than one type of inflammation (e.g., type 1, type 2, and type 3) may coexist in the individual patient. […] The contemporary standard of care in treating CRSwNP includes therapeutics modulating or decreasing the inflammatory response in the sinonasal mucosa, with endoscopic sinus surgery (ESS) recommended for patients refractory to optimal medical therapy. Optimal medical therapy for CRSwNP as recommended by consensus guidelines includes high-volume saline rinse and topical nasal steroids with or without short courses of systemic corticosteroids. […] Biologics are monoclonal antibodies developed through recombinant technology. They act by targeting a specific protein considered germane in the pathogenesis of a disease. Three biologics targeting type 2 inflammation in CRSwNP have recently been approved by the U.S. Food and Drugs Administration (FDA): dupilumab, mepolizumab, and omalizumab.

• #20 Nonsurgical Treatment of Nasal Polyps Treatment & Management: Medical Care, Surgical Care, Consultations

  https://emedicine.medscape.com/article/861353-treatment

  In June 2019, the US Food and Drug Administration (FDA) approved dupilumab for treatment in adults with inadequately controlled, severe chronic rhinosinusitis with nasal polyps (CRSwNP). […] Subsequent to dupilumab, the monoclonal antibodies omalizumab and mepolizumab also received FDA approval for use against CRSwNP, again for adult patients in whom the condition is inadequately controlled. […] A study published in 2023 also found dupilumab to be effective against CRSwNP. […] A prospective study by Tanzini et al indicated that dupilumabs effects against CRSwNP are delayed in patients with asthma or atopy. […] In a study of omalizumab treatment in 23 adult patients with recalcitrant chronic rhinosinusitis with nasal polyps, as well as comorbid mild asthma, Armengot-Carceller et al found that all subjects experienced significant and sustained reductions in the total nasal endoscopic polyp score.

• #21 Chronic rhinosinusitis with nasal polyposis: Management and prognosis – UpToDate

  https://www.uptodate.com/contents/chronic-rhinosinusitis-with-nasal-polyposis-management-and-prognosis

  Functional endoscopic sinus surgery (FESS), when applied to patients with CRSwNP, is intended to remove polypoid material and inflammatory debris and maximize physiologic sinus ventilation and drainage to facilitate the gradual resolution of mucosal disease. In addition, widening of the outflow tracts allows for improved penetration by topical medications following surgery. Mucosal preservation is the universally accepted technique for both CRS with and without polyps to avoid excessive scarring and to maintain normal mucociliary clearance. […] For patients with recurrent polyps after FESS, we suggest a biologic therapy rather than more intensive INCS therapy or revision sinus surgery. There are three „respiratory” (ie, effective for asthma) biologics that are also approved for treatment of CRSwNP in the United States and Europe: dupilumab, omalizumab, and mepolizumab.

• #22 Biologics for Chronic Rhinosinusitis with Nasal Polyps | AAO-HNS Bulletin

  https://bulletin.entnet.org/clinical-patient-care/article/22881642/biologics-for-chronic-rhinosinusitis-with-nasal-polyps

  The product label for biologics states these to be add-on maintenance treatments for adult patients who have inadequately controlled nasal polyps. […] Currently, optimal indications for the use of biologics may be best used over standard of care are yet to be defined. Although some patients may be super responders, responses in other patients may be underwhelming. Indeed, biologics appear to work effectively in approximately 60%-70% of patients they are used in, leading to questions regarding which patients may be best suited to benefit. […] The 2020 European position paper on sinusitis (EPOS) proposed the use of biologics may be appropriate in patients with bilateral nasal polyposis who had undergone previous endoscopic sinus surgery and met three of five additional criteria: evidence of type 2 inflammation, use of systemic steroid treatment chronically or over twice a year, SNOT-22 score 40, reduced smell, and asthma requiring inhaled steroids.

• #23 Nasal Polyps – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK560746/

  For more severe disease, oral corticosteroids may be prescribed in pulses and tapered gradually. […] While antibiotics can be used to treat acute infections, their role in CRSwNP remains controversial. […] Failure to respond to medical treatment or the presence of severe symptoms may necessitate surgery. […] Continued medical management is essential to optimize surgical outcomes.

• #24 Nasal Polyps | Cedars-Sinai

  https://www.cedars-sinai.org/health-library/diseases-and-conditions/n/nasal-polyps.html

  Treatment will depend on your symptoms, age, and general health. It will also depend on how severe the condition is. […] Treatment aims to reduce inflammation, as well as the size of your polyps. Healthcare providers often start treatment with steroid medicines breathed in (inhaled) through the nose. These medicines can decrease the inflammation at the root of the problem. People who dont respond to this might need steroid medicines taken by mouth. […] Other treatments for nasal polyps include: […] Medicines to help decrease inflammation (antileukotrienes) […] Antibiotics for possible infection […] Nasal steroid sprays […] Daily rinsing of the sinuses with a saltwater solution […] Antihistamines to reduce allergic reactions […] Allergen immunotherapy and removal of allergens, if possible

• #25 Nasal Polyps – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK560746/

  Nasal polyps are benign, inflammatory outgrowths of the sinonasal mucosa that can lead to chronic nasal obstruction, congestion, and diminished quality of life. […] Management strategies range from medical therapies, such as intranasal corticosteroids, saline irrigation, and biologics, to surgical intervention in refractory cases. Endoscopic sinus surgery may be necessary for symptom relief and restoration of nasal airflow. […] For patients with CRSwNP, initial therapy with intranasal corticosteroids and nasal saline irrigations for approximately 2 to 3 months should be attempted. High-volume, low-pressure nasal saline irrigations are a safe and inexpensive method that increases the clearance of antigens, biofilms, and inflammatory mediators. Intranasal corticosteroids help alleviate nasal congestion and reduce polyp size.

• #26 Nasal Polyps – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK560746/

  For more severe disease, oral corticosteroids may be prescribed in pulses and tapered gradually. […] While antibiotics can be used to treat acute infections, their role in CRSwNP remains controversial. […] Failure to respond to medical treatment or the presence of severe symptoms may necessitate surgery. […] Continued medical management is essential to optimize surgical outcomes.

• #27 Nasal Polyps

  https://www.aaaai.org/tools-for-the-public/conditions-library/allergies/nasal-polyps

  Medical treatment of CRSwNP includes both topical nasal steroid sprays and nasal saline rinses. Steroid sprays help reduce polyp size and improve symptoms and are very safe for long-term use. Short courses of oral steroids can also help shrink nasal polyps and have shown to improve symptoms including sense of smell, however they should be used cautiously given the risk of steroid side effects. […] Sinus surgery to remove polyps is an option if nasal polyps are bothersome despite oral and/or corticosteroid sprays. Unfortunately, polyps often recur despite surgery and long-term treatment with nasal steroids or large volume steroids are often necessary. […] More recently, different steroid delivery options have been utilized for treatment of CRSwNP. Large volume nasal steroid rinses with squeeze plastic bottles have been shown to be superior to traditional steroid sprays. Exhalation delivery system with fluticasone is a recently approved steroid device that sprays fluticasone deeper into the nasal cavity to reduce inflammation from nasal polyps. Stents that deliver topical steroids can also be inserted by surgeons and have shown benefit in reducing polyp recurrence. Other medications that have shown some benefit in the treatment of nasal polyps include leukotriene inhibitors such as montelukast. Additionally, antibiotics are occasionally prescribed if there is a concern for infection although there is not much scientific evidence for their efficacy. Finally, biologic medications (dupilumab, mepolizumab and omalizumab), which have been approved to treat moderate to severe asthma, have also gained approval to treat CRSwNP. These are given as injections every 2-4 weeks and have been shown to reduce the need for surgery and treatment with oral steroids.

• #28 Nasal Polyps | Cedars-Sinai

  https://www.cedars-sinai.org/health-library/diseases-and-conditions/n/nasal-polyps.html

  Treatment will depend on your symptoms, age, and general health. It will also depend on how severe the condition is. […] Treatment aims to reduce inflammation, as well as the size of your polyps. Healthcare providers often start treatment with steroid medicines breathed in (inhaled) through the nose. These medicines can decrease the inflammation at the root of the problem. People who dont respond to this might need steroid medicines taken by mouth. […] Other treatments for nasal polyps include: […] Medicines to help decrease inflammation (antileukotrienes) […] Antibiotics for possible infection […] Nasal steroid sprays […] Daily rinsing of the sinuses with a saltwater solution […] Antihistamines to reduce allergic reactions […] Allergen immunotherapy and removal of allergens, if possible

• #29 UT Physicians | New Treatments for Nasal Polyps

  https://www.utphysicians.com/new-treatments-for-nasal-polyps/

  New treatments for nasal polyps can help you breathe again, and they can improve your sense of smell. […] Treatment of nasal polyps starts with medications directed at reducing inflammation. Topical nasal steroid sprays and prednisone both reduce polyp size. […] After surgery, most patients with polyps will need additional topical treatments as part of a long-term treatment strategy. […] For these patients, new topical steroid delivery devices may be a great option. […] Lastly, a new class of treatment, known as biologics, has been introduced. These medicines are aimed to turn off the triggers that cause nasal polyps to form. […] Topical medications may also be prescribed through a compounding pharmacy for the treatment of nasal polyps, especially after sinus surgery. […] Recently, a new way to delivery steroids into the sinuses has been introduced. Known as exhalation delivery system, this device pushes fluticasone (a steroid) high and deep into the sinuses.

• #30 UT Physicians | New Treatments for Nasal Polyps

  https://www.utphysicians.com/new-treatments-for-nasal-polyps/

  Over the past several years, steroid-releasing implants, which release mometasone (a steroid) as they dissolve, have been used at the end of conventional sinus surgery. […] More recently, a steroid-releasing implant designed for in-office (rather than operating room) placement has been introduced. […] Recent treatment advances have changed the role of functional endoscopic sinus surgery (FESS). […] In these instances, FESS, combined with long-term topical steroid delivery, is a good option. […] For many patients, a targeted revision procedure, which may even be performed in the office, sets the stage for other treatments, including steroid delivery devices, which avoid the need for systemic prednisone.

• #31 Non-Surgical Nasal Polyps Treatment | FDA Approved | SINUVA

  https://www.sinuva.com/nasal-polyps-treatment/

  SINUVA is an option for the treatment of nasal polyps thats been shown to provide effective relief, compared to daily steroid nasal spray alone in a clinical trial with 300 patients. […] SINUVA is not a surgery; its a stent inserted into the ethmoid sinus cavity through the nasal opening during a routine office visit using local anesthesia and delivers anti-inflammatory medication right to the nasal polyps. […] SINUVA was proven to shrink nasal polyps and reduce symptoms of nasal obstruction and congestion for up to 90 days. Patients treated with SINUVA had reduced sinus obstruction and reported an improved impaired sense of smell compared to patients treated with daily steroid nasal spray. […] SINUVA is designed to deliver anti-inflammatory medicine over the course of 90 days. […] SINUVA is a prescription steroid-releasing implant indicated for the treatment of chronic rhinosinusitis with nasal polyps in adult patients 18 years or older who have had ethmoid sinus surgery.

• #32 UT Physicians | New Treatments for Nasal Polyps

  https://www.utphysicians.com/new-treatments-for-nasal-polyps/

  Over the past several years, steroid-releasing implants, which release mometasone (a steroid) as they dissolve, have been used at the end of conventional sinus surgery. […] More recently, a steroid-releasing implant designed for in-office (rather than operating room) placement has been introduced. […] Recent treatment advances have changed the role of functional endoscopic sinus surgery (FESS). […] In these instances, FESS, combined with long-term topical steroid delivery, is a good option. […] For many patients, a targeted revision procedure, which may even be performed in the office, sets the stage for other treatments, including steroid delivery devices, which avoid the need for systemic prednisone.

• #33 Chronic rhinosinusitis with nasal polyposis: Management and prognosis – UpToDate

  https://www.uptodate.com/contents/chronic-rhinosinusitis-with-nasal-polyposis-management-and-prognosis

  Short courses of oral glucocorticoids can be used to temporarily shrink nasal polyps, which is helpful for patients who present with such severe nasal blockage that they cannot effectively use an intranasal corticosteroid (INCS) or in the setting of severe symptoms of nasal congestion or anosmia. […] We instruct patients to perform daily or twice-daily, high-volume nasal irrigations with a saline solution, in agreement with multiple consensus statements. We recommend this for all patients with CRSwNP who can tolerate it and are not completely obstructed. Saline irrigations thin and flush out mucus, inflammatory debris, irritants, and allergens and improve mucociliary function. […] Guidelines and consensus statements recommend topical intranasal corticosteroids (INCS) as first-line treatment for CRSwNP. We typically start with an INCS delivered via nasal spray, many of which are available without a prescription. There are several other delivery systems in addition to nasal sprays, including rinses/irrigations, drops, and an exhalation-driven delivery system (EDS).

• #34 Nasal Polyps: Symptoms, Causes, Treatment & Removal

  https://my.clevelandclinic.org/health/diseases/15250-nasal-polyps

  Nasal polyp treatment depends on the severity of your condition. Medication and surgery are the two main approaches. […] Even with surgical removal, nasal polyps may grow back over time. Your healthcare provider will talk to you about the likelihood of recurrence (return) and how you can manage it. […] Medication usually doesn’t get rid of nasal polyps, but it can ease symptoms. Common treatments include: […] Steroid nasal sprays to shrink polyps and improve symptoms. […] Oral steroids (pills you swallow) like prednisone. […] Biologic medications, such as dupilumab injections. (Dupilumab contains monoclonal antibodies that stimulate your immune system and may shrink nasal polyps.) […] If medication doesn’t work or if you have large polyps you may need sinus surgery to remove them. Your provider may use nasal endoscopy to do one of these minimally invasive procedures:

• #35 Nasal Polyps: Symptoms, Causes, Treatment & Removal

  https://my.clevelandclinic.org/health/diseases/15250-nasal-polyps

  Polypectomy. A healthcare provider uses tiny instruments like surgical scissors or snares to grab onto and remove the polyps inside your nose. […] Balloon sinuplasty. A surgeon threads a small balloon through your nostril and into your sinus cavity. […] Functional endoscopic sinus surgery (FESS). A surgeon uses small instruments to remove polyps, diseased tissue, damaged bone and anything else that obstructs your nasal passages. […] All these procedures are minimally invasive. That means your surgeon does everything through your nostrils. So, you won’t have visible incisions or sutures. […] Treatment can help you get rid of nasal polyps and make it easier for you to breathe through your nose. But unfortunately, polyps can come back after treatment. Some people need to stay on steroid medications or have repeat surgery to manage them. […] If you develop nasal polyp symptoms, tell your healthcare provider right away. They can find a treatment option that works for your situation.

• #36 Nasal Polyps: Symptoms, Causes, Treatment & Removal

  https://my.clevelandclinic.org/health/diseases/15250-nasal-polyps

  Polypectomy. A healthcare provider uses tiny instruments like surgical scissors or snares to grab onto and remove the polyps inside your nose. […] Balloon sinuplasty. A surgeon threads a small balloon through your nostril and into your sinus cavity. […] Functional endoscopic sinus surgery (FESS). A surgeon uses small instruments to remove polyps, diseased tissue, damaged bone and anything else that obstructs your nasal passages. […] All these procedures are minimally invasive. That means your surgeon does everything through your nostrils. So, you won’t have visible incisions or sutures. […] Treatment can help you get rid of nasal polyps and make it easier for you to breathe through your nose. But unfortunately, polyps can come back after treatment. Some people need to stay on steroid medications or have repeat surgery to manage them. […] If you develop nasal polyp symptoms, tell your healthcare provider right away. They can find a treatment option that works for your situation.

• #37 Advanced sinus surgery relieves nasal polyp symptoms – without a long recovery | Discovery | ENT | Men’s Health | UT Southwestern Medical Center

  https://utswmed.org/medblog/nasal-polyps-advanced-sinus-surgery/

  Anti-inflammatory steroid spray is the first line of treatment. Steroids reduce the volume of white blood cells involved in the inflammation that causes nasal polyps. […] If nasal sprays do not reduce the inflammation enough, we may recommend an oral or injectable steroid, such as prednisone. […] In the past few years, the U.S. Food and Drug Administration has approved a couple of monoclonal antibody medications to treat nasal polyps: dupilumab and omalizumab. […] Because of this, it’s important we find the perfect mix of medical and surgical treatment to get the best results for you over the long term. […] If medication alone does not alleviate your symptoms or the polyps continue to regrow, we may begin to discuss surgery. […] Today’s sinus surgery, which is called functional endoscopic sinus surgery (FESS), is very different from even 10 years ago.

• #38 Nasal Polyps: Symptoms, Causes, Treatment & Removal

  https://my.clevelandclinic.org/health/diseases/15250-nasal-polyps

  Polypectomy. A healthcare provider uses tiny instruments like surgical scissors or snares to grab onto and remove the polyps inside your nose. […] Balloon sinuplasty. A surgeon threads a small balloon through your nostril and into your sinus cavity. […] Functional endoscopic sinus surgery (FESS). A surgeon uses small instruments to remove polyps, diseased tissue, damaged bone and anything else that obstructs your nasal passages. […] All these procedures are minimally invasive. That means your surgeon does everything through your nostrils. So, you won’t have visible incisions or sutures. […] Treatment can help you get rid of nasal polyps and make it easier for you to breathe through your nose. But unfortunately, polyps can come back after treatment. Some people need to stay on steroid medications or have repeat surgery to manage them. […] If you develop nasal polyp symptoms, tell your healthcare provider right away. They can find a treatment option that works for your situation.

• #39 Nasal Polyps: Symptoms, Causes, Treatment & Removal

  https://my.clevelandclinic.org/health/diseases/15250-nasal-polyps

  Polypectomy. A healthcare provider uses tiny instruments like surgical scissors or snares to grab onto and remove the polyps inside your nose. […] Balloon sinuplasty. A surgeon threads a small balloon through your nostril and into your sinus cavity. […] Functional endoscopic sinus surgery (FESS). A surgeon uses small instruments to remove polyps, diseased tissue, damaged bone and anything else that obstructs your nasal passages. […] All these procedures are minimally invasive. That means your surgeon does everything through your nostrils. So, you won’t have visible incisions or sutures. […] Treatment can help you get rid of nasal polyps and make it easier for you to breathe through your nose. But unfortunately, polyps can come back after treatment. Some people need to stay on steroid medications or have repeat surgery to manage them. […] If you develop nasal polyp symptoms, tell your healthcare provider right away. They can find a treatment option that works for your situation.

• #40 Chronic rhinosinusitis with nasal polyposis: Management and prognosis – UpToDate

  https://www.uptodate.com/contents/chronic-rhinosinusitis-with-nasal-polyposis-management-and-prognosis

  Functional endoscopic sinus surgery (FESS), when applied to patients with CRSwNP, is intended to remove polypoid material and inflammatory debris and maximize physiologic sinus ventilation and drainage to facilitate the gradual resolution of mucosal disease. In addition, widening of the outflow tracts allows for improved penetration by topical medications following surgery. Mucosal preservation is the universally accepted technique for both CRS with and without polyps to avoid excessive scarring and to maintain normal mucociliary clearance. […] For patients with recurrent polyps after FESS, we suggest a biologic therapy rather than more intensive INCS therapy or revision sinus surgery. There are three „respiratory” (ie, effective for asthma) biologics that are also approved for treatment of CRSwNP in the United States and Europe: dupilumab, omalizumab, and mepolizumab.

• #41 Nasal Polyps: Symptoms, Causes, Treatment & Removal

  https://my.clevelandclinic.org/health/diseases/15250-nasal-polyps

  Polypectomy. A healthcare provider uses tiny instruments like surgical scissors or snares to grab onto and remove the polyps inside your nose. […] Balloon sinuplasty. A surgeon threads a small balloon through your nostril and into your sinus cavity. […] Functional endoscopic sinus surgery (FESS). A surgeon uses small instruments to remove polyps, diseased tissue, damaged bone and anything else that obstructs your nasal passages. […] All these procedures are minimally invasive. That means your surgeon does everything through your nostrils. So, you won’t have visible incisions or sutures. […] Treatment can help you get rid of nasal polyps and make it easier for you to breathe through your nose. But unfortunately, polyps can come back after treatment. Some people need to stay on steroid medications or have repeat surgery to manage them. […] If you develop nasal polyp symptoms, tell your healthcare provider right away. They can find a treatment option that works for your situation.

• #42 Nasal Polyps: Symptoms, Causes, Treatment & Removal

  https://my.clevelandclinic.org/health/diseases/15250-nasal-polyps

  Polypectomy. A healthcare provider uses tiny instruments like surgical scissors or snares to grab onto and remove the polyps inside your nose. […] Balloon sinuplasty. A surgeon threads a small balloon through your nostril and into your sinus cavity. […] Functional endoscopic sinus surgery (FESS). A surgeon uses small instruments to remove polyps, diseased tissue, damaged bone and anything else that obstructs your nasal passages. […] All these procedures are minimally invasive. That means your surgeon does everything through your nostrils. So, you won’t have visible incisions or sutures. […] Treatment can help you get rid of nasal polyps and make it easier for you to breathe through your nose. But unfortunately, polyps can come back after treatment. Some people need to stay on steroid medications or have repeat surgery to manage them. […] If you develop nasal polyp symptoms, tell your healthcare provider right away. They can find a treatment option that works for your situation.

• #43 Advanced sinus surgery relieves nasal polyp symptoms – without a long recovery | Discovery | ENT | Men’s Health | UT Southwestern Medical Center

  https://utswmed.org/medblog/nasal-polyps-advanced-sinus-surgery/

  We pair sophisticated computer guidance with our surgical expertise to navigate more precisely within the sinuses and remove polyps. […] You will be asleep under general anesthesia during the procedure. […] After surgery, you should be able to go home the same day you will need a ride home. […] Patients say the difference between living with nasal polyps and finding the right treatment is like night and day. They can breathe easier and sleep better, which means they can get back to enjoying their lives and we are honored to be a part of making that happen.

• #44 Nasal Polyps: Symptoms, Causes, Treatment & Removal

  https://my.clevelandclinic.org/health/diseases/15250-nasal-polyps

  Polypectomy. A healthcare provider uses tiny instruments like surgical scissors or snares to grab onto and remove the polyps inside your nose. […] Balloon sinuplasty. A surgeon threads a small balloon through your nostril and into your sinus cavity. […] Functional endoscopic sinus surgery (FESS). A surgeon uses small instruments to remove polyps, diseased tissue, damaged bone and anything else that obstructs your nasal passages. […] All these procedures are minimally invasive. That means your surgeon does everything through your nostrils. So, you won’t have visible incisions or sutures. […] Treatment can help you get rid of nasal polyps and make it easier for you to breathe through your nose. But unfortunately, polyps can come back after treatment. Some people need to stay on steroid medications or have repeat surgery to manage them. […] If you develop nasal polyp symptoms, tell your healthcare provider right away. They can find a treatment option that works for your situation.

• #45 Get Nasal Polyps Treatment | Cleveland Clinic

  https://my.clevelandclinic.org/services/nasal-polyps-treatment

  We offer personalized treatment plans to care for your nasal polyps and help relieve your symptoms. […] For some people, medication can shrink nasal polyps and get you back to smelling, sleeping and breathing easily. […] Your treatment may begin with antibiotics, steroid nasal sprays or steroid pills. […] Your team may also recommend injection (shot) therapy of an anti-inflammatory medication called dupilumab, which helps to control congestion and shrink nasal polyps. […] If medication doesn’t do the trick, your provider may recommend surgery. […] Even after surgery or with medication, nasal polyps can be stubborn, and it’s common for them to come back. […] Your team will help you manage them.

• #46 Nasal Polyps – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK560746/

  When CRSwNP is refractory to adequate medical treatment, functional endoscopic sinus surgery (FESS) is planned. […] Topical intranasal steroids form an essential part of CRSwNP treatment postoperatively. […] Continuing nasal saline irrigations and intranasal corticosteroids after surgery improves the likelihood of long-term success. […] If a patient remains symptomatic despite the strategies above, oral corticosteroids may be used. […] Biologic drugs, such as monoclonal antibodies, may be considered for patients with refractory disease. […] Treatment of the underlying condition is essential for patients with a systemic disease associated with nasal polyps, such as EGPA or cystic fibrosis. […] Intranasal corticosteroids, such as budesonide, fluticasone propionate, and mometasone furoate, effectively reduce polyp size.

• #47 Nasal Polyps – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK560746/

  When CRSwNP is refractory to adequate medical treatment, functional endoscopic sinus surgery (FESS) is planned. […] Topical intranasal steroids form an essential part of CRSwNP treatment postoperatively. […] Continuing nasal saline irrigations and intranasal corticosteroids after surgery improves the likelihood of long-term success. […] If a patient remains symptomatic despite the strategies above, oral corticosteroids may be used. […] Biologic drugs, such as monoclonal antibodies, may be considered for patients with refractory disease. […] Treatment of the underlying condition is essential for patients with a systemic disease associated with nasal polyps, such as EGPA or cystic fibrosis. […] Intranasal corticosteroids, such as budesonide, fluticasone propionate, and mometasone furoate, effectively reduce polyp size.

• #48 Nasal polyps – Australasian Society of Clinical Immunology and Allergy (ASCIA)

  https://www.allergy.org.au/patients/allergic-rhinitis-hay-fever-and-sinusitis/nasal-polyps

  Allergen immunotherapy (AIT), also known as desensitisation, is sometimes used in people with allergic rhinitis (hay fever) who also have nasal polyps. While AIT often helps allergic rhinitis symptoms, it is not known if AIT helps shrink nasal polyps. […] Some people have nasal polyps, asthma, and an aspirin allergy. These three conditions together are often referred to as the aspirin triad. Treatment may include aspirin desensitisation which can reduce asthma severity, the rate of polyp regrowth, and the severity of sinusitis.

• #49 Chronic rhinosinusitis with nasal polyposis: Management and prognosis – UpToDate

  https://www.uptodate.com/contents/chronic-rhinosinusitis-with-nasal-polyposis-management-and-prognosis

  Dupilumab, a monoclonal antibody targeting interleukin 4 receptor alpha (IL-4R-alpha), inhibits signaling of the cytokines IL-4 and IL-13, two pivotal drivers of type 2 inflammation that are important in diseases such as CRSwNP and asthma. Dupilumab reduces nasal congestion/blockage, endoscopic and radiologic sinus inflammation, rhinorrhea, postnasal drip, need for oral glucocorticoids, and need for FESS and improves sense of smell in patients with CRSwNP. […] Patients with aspirin-exacerbated respiratory disease (AERD), the triad of adult-onset asthma, CRSwNP, and upper and/or lower respiratory reactions to nonsteroidal antiinflammatory drugs (NSAIDs), have particularly severe CRSwNP. Aspirin desensitization and daily aspirin therapy is a treatment option that is only appropriate for patients with AERD.

• #50 Chronic rhinosinusitis with nasal polyposis: Management and prognosis – UpToDate

  https://www.uptodate.com/contents/chronic-rhinosinusitis-with-nasal-polyposis-management-and-prognosis

  We usually ask patients with CRSwNP to return three to six months after initiation of therapy and then every 6 to 12 months thereafter until symptoms are adequately managed. At each visit, we assess sinonasal symptoms and quality of life (QoL), perform a nasal exam (endoscopic if available), and review any use of oral glucocorticoids or antibiotics for exacerbations.

• #51 Advanced sinus surgery relieves nasal polyp symptoms – without a long recovery | Discovery | ENT | Men’s Health | UT Southwestern Medical Center

  https://utswmed.org/medblog/nasal-polyps-advanced-sinus-surgery/

  UT Southwestern’s Dr. Matthew Ryan and his colleagues are experts in functional endoscopic sinus surgery (FESS), which combines their knowledge of the delicate sinus cavities and nearby structures with the latest technology to remove nasal polyps. […] But today, there are effective, minimally invasive treatments that can offer immediate and sometimes permanent relief. […] We also perform revisionary surgery for patients who have had unsuccessful or incomplete surgery in the past. […] There is not yet a cure for nasal polyps. While we can remove polyps, there is a chance they will return. However, treatment options are becoming more advanced every day, resulting in more days, months, or even years without intrusive nasal polyp symptoms. […] When it comes to choosing the best treatment, shared decision-making is key we will give you all the options and make recommendations for what we think will be most effective for you.

• #52 Nasal Polyps | Cedars-Sinai

  https://www.cedars-sinai.org/health-library/diseases-and-conditions/n/nasal-polyps.html

  Aspirin desensitization therapy, if appropriate […] A biologic medicine called dupilumab given as a shot (injection) every other week. […] If this is the case, surgery may help. Surgery does often get rid of most symptoms. But the polyps may come back within a few months to a few years. It is important to address the underlying cause of your nasal polyps to help prevent this from happening. After your surgery, you may need to take inhaled nasal steroids to help keep the polyps from returning. […] Therapy aimed at the cause can help keep your polyps in check. It may also help prevent them from coming back if you have had surgery. Following all your healthcare providers treatment instructions can help.

• #53 Advanced sinus surgery relieves nasal polyp symptoms – without a long recovery | Discovery | ENT | Men’s Health | UT Southwestern Medical Center

  https://utswmed.org/medblog/nasal-polyps-advanced-sinus-surgery/

  UT Southwestern’s Dr. Matthew Ryan and his colleagues are experts in functional endoscopic sinus surgery (FESS), which combines their knowledge of the delicate sinus cavities and nearby structures with the latest technology to remove nasal polyps. […] But today, there are effective, minimally invasive treatments that can offer immediate and sometimes permanent relief. […] We also perform revisionary surgery for patients who have had unsuccessful or incomplete surgery in the past. […] There is not yet a cure for nasal polyps. While we can remove polyps, there is a chance they will return. However, treatment options are becoming more advanced every day, resulting in more days, months, or even years without intrusive nasal polyp symptoms. […] When it comes to choosing the best treatment, shared decision-making is key we will give you all the options and make recommendations for what we think will be most effective for you.

• #54 Nasal Polyps Diagnosis & Treatment NYC | Mount Sinai – New York

  https://www.mountsinai.org/care/ent/services/nasal-sinus-allergy/conditions/nasal-polyps

  Nasal polyps are small growths that develop inside your nose or sinuses. […] Medications such as nasal sprays (particularly those containing steroids to reduce swelling and help shrink the polyps) and drugs to control allergies or infection (i.e. antihistamines for allergies or antibiotics for a bacterial infection) can help control symptoms of polyps. In some cases, surgery may be required. At Mount Sinai, our experts are leaders in endoscopic sinus surgery, which involves removing the nasal polyps and opening the sinuses where the growths had formed. […] Recent research advancements in topical steroid delivery are transforming the way we manage our patients who suffer from chronic sinusitis.

• #55 Growing Role of Biologics in the Nasal Polyposis Treatment Market

  https://www.delveinsight.com/blog/biologics-in-the-nasal-polyposis-treatment-market

  The primary objective of the current nasal polyposis treatment is to slow the growth of the polyps, delay surgery, or prevent relapse after surgery. […] Over the years, the US FDA has approved various corticosteroids for nasal polyposis treatment, which include XHANCE (fluticasone propionate), SINUVA (mometasone furoate) Sinus Implant, PROPEL (mometasone furoate), but these are not curative, leaving the patients vulnerable. […] The recent approval of biologics as add-on therapy has provided optimism for patients with cystic fibrosis. There are currently three approved biologics for nasal polyposis treatment, which include DUPIXENT (dupilumab), NUCALA (mepolizumab), and XOLAIR (omalizumab). […] Experts say biologics are considered before primary surgery, particularly in patients whose conditions like asthma are present simultaneously with CRSwNP, in those for whom surgery is less available, in patients who refuse surgery, and in patients with a high complication ratio.

• #56 Understanding Nasal Polyps and Type 2 Inflammation

  https://www.thenextbreath.com/nasal-polyps

  If you have nasal polyps, or chronic rhinosinusitis with nasal polyposis (CRSwNP), you know about the constant runny nose, nasal congestion, facial pain and loss of smell. But did you know that science is changing the way we understand this condition? […] Nasal sprays, steroids and surgery can be effective. However, they don’t always provide lasting relief, because they don’t target the type 2 inflammation associated with nasal polyps. […] Ask your doctor how science is changing the face of nasal polyps.

• #57 Biologics for Chronic Rhinosinusitis with Nasal Polyps | AAO-HNS Bulletin

  https://bulletin.entnet.org/clinical-patient-care/article/22881642/biologics-for-chronic-rhinosinusitis-with-nasal-polyps

  Three biologics targeting type 2 inflammation have recently been approved by the FDA for nasal polyps: dupilumab, mepolizumab, and omalizumab. These appear to reduce nasal polyp size and positively impact sinonasal symptoms and quality of life with varying efficacy. Many questions on the use of biologics for nasal polyps currently remain unanswered regarding the length of treatment, who benefits most, and whether biologics should be used with, without, before, or after surgery.

Zobacz więcej