Materiały źródłowe

• #1 Undifferentiated Pleomorphic Sarcoma: Symptoms & Treatment

  https://my.clevelandclinic.org/health/diseases/22435-undifferentiated-pleomorphic-sarcoma

  Undifferentiated pleomorphic sarcoma (UPS) is a rare type of soft tissue cancer that spreads quickly. Symptoms arent always obvious, but they may include a lump, pain, swelling or unexplained weight loss. […] Undifferentiated pleomorphic sarcoma symptoms might include: A growing lump, A painless lump or mass that may or may not move when you touch it, Numbness or tingling if a lump or mass is pushing on or arising from a nerve, Swelling in an arm or leg. […] UPS doesnt always cause noticeable symptoms. Its most often painless, doesnt have any skin changes over the top and doesnt typically cause symptoms like fever, weight loss or general malaise. […] Life expectancy varies depending on the size and stage of the sarcoma. The five-year survival rate for high-grade UPS is about 60%. That means that around 60% of people diagnosed with this condition are still alive five years later. The 10-year survival rate is 48%. […] Its possible to cure UPS, especially during the early stages. There still may be treatment options in later stages, which can prolong your quality of life. Like any type of cancer, early detection and treatment increase your chances for successful outcomes.

• #1 Undifferentiated Pleomorphic Sarcoma – MD Searchlight

  https://mdsearchlight.com/cancer/undifferentiated-pleomorphic-sarcoma/

  Undifferentiated pleomorphic sarcoma (UPS) usually shows up as a painless, rapidly growing lump under the skin or on the surface of the skin without any visible skin changes. […] If UPS forms inside the body, in the chest, or in the stomach area, it might cause symptoms due to the growing mass. There might also be general body symptoms like fever or weight loss. […] In a recent review of 100 UPS cases, most tumors were found in the arms or legs (55%), followed by the torso or trunk (35%), behind the stomach area (9%), and in the left upper chamber of the heart (1%). […] The average tumor size is approximately 8.8 cm. […] If UPS is related to previous radiation therapy, it usually takes about 9.33 years for the tumor to develop after the radiation treatment.

• #1 Undifferentiated pleomorphic sarcoma – Symptoms and causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/undifferentiated-pleomorphic-sarcoma/symptoms-causes/syc-20389554

  Undifferentiated pleomorphic sarcoma symptoms depend on where the cancer occurs. It most often happens in the arms and legs, but it can happen anywhere in the body. […] Signs and symptoms may include: […] Growing lump or area of swelling. […] If it grows very large, there may be pain, tingling and numbness. […] If it occurs in an arm or leg, there may be swelling in the hand or foot of an affected limb. […] If it occurs in the abdomen, there may be pain, loss of appetite and constipation. […] Fever. […] Weight loss.

• #1 Cancer of the Connective Tissues: Soft-Tissue Sarcoma | HSS

  https://www.hss.edu/condition-list_soft-tissue-sarcoma.asp

  Patients usually notice an enlarging mass or lump in the arm or leg. […] The mass is usually painless, leading many to ignore it until it reaches substantial size. […] If the mass presses on a nearby nerve, it may lead to numbness or tingling in an extremity. […] The growth rate of soft-tissue sarcoma is highly variable, but in general it will grow noticeably over weeks to months. […] Any mass that grows in this time frame needs urgent medical evaluation. […] Even a mass that grows slowly over years should still be evaluated to determine if cancer is present.

• #1 Undifferentiated Pleomorphic Sarcoma: Causes, Symptoms and Treatment | Apollo Hospitals

  https://www.apollohospitals.com/diseases-and-conditions/undifferentiated-pleomorphic-sarcoma-causes-symptoms-and-treatment

  The symptoms of undifferentiated pleomorphic sarcoma depend on its location (where it has grown) and the size of the lump. It generally affects the arms and legs but may occur in any part of the body. Some of the symptoms that may appear are: […] Growing lump or swelling in the area affected […] Pain, tingling or numbness where the cancer is growing […] Loss of appetite […] Diarrhea or constipation if it occurs in the abdominal region […] Fever and chills […] Unexpected weight loss […] Pain in the bones. […] Undifferentiated pleomorphic sarcoma can be extremely aggressive and may require immediate treatment to stop it from growing.

• #1 Undifferentiated Pleomorphic Sarcoma

  https://sarcomaoncology.com/types-of-sarcoma/soft-tissue-sarcomas/uncertain-differentiation-undifferentiated-pleomorphic-sarcoma/

  Undifferentiated pleomorphic sarcoma is a malignant sarcoma that grows quickly and spreads to other parts of the body, including the lungs. […] It usually occurs in older adults and may sometimes occur as a second sarcoma in patients who have retinoblastoma, a kind of eye cancer that starts in the retina. […] Like other subtypes of soft tissue sarcoma, uncertain differentiation may not have noticeable symptoms until it has reached an advanced stage or spread to another part of the body. Therefore, it is critical to pay attention to any abnormal signs and symptoms you may experience to ensure timely treatment for malignant tumors. […] Symptoms of uncertain differentiation may include: Lump formation, Painful swelling, Weight loss, Fatigue, Nausea and vomiting, Breathing difficulty, Muscle weakness.

• #1 Cardiac undifferentiated pleomorphic sarcoma | Radiology Reference Article | Radiopaedia.org

  https://radiopaedia.org/articles/cardiac-undifferentiated-pleomorphic-sarcoma?lang=us

  Cardiac undifferentiated pleomorphic sarcomas are highly malignant mesenchymal tumors of the heart. […] Clinical signs and symptoms are related to the left atrium and might include dyspnea, palpitations and symptoms of heart failure or non-specific constitutional symptoms such as fever and weight loss. […] Cardiac undifferentiated pleomorphic sarcomas might cause the following complications: arrhythmias as atrial fibrillation, atrioventricular block or ventricular tachycardia, embolic events, heart failure, pericardial effusion, distant metastases. […] Cardiac undifferentiated pleomorphic sarcomas are characterized by a very poor prognosis with a median survival of less than a year.

• #1 Malignant fibrous histiocytoma of the bone

  https://www.medicalnewstoday.com/articles/malignant-fibrous-histiocytoma-of-bone

  When someone has UPS in their bones, they may feel bone pain and notice swelling or a lump. […] They may also experience some pain in their joints. As the tumor grows, it can weaken the bone, increasing the risk of a break or fracture. […] Other possible symptoms include a lump that feels soft or warm to the touch or an unexplained fever. […] Symptoms of UPS are similar to other types of bone cancer in that people would likely first notice a lump on their leg or arm that may feel painful.

• #1 Undifferentiated pleomorphic sarcoma – Wikipedia

  https://en.wikipedia.org/wiki/Undifferentiated_pleomorphic_sarcoma

  UPS commonly presents as a deep-seated, rapidly enlarging, painless mass in individuals aged 50 to 70 years. […] The majority of UPS tumors are highly aggressive, often recur after surgical removal, and often metastasize. […] In a retrospective study, distant metastases were detected at the time of initial diagnosis in 6.4% of 266 individuals. […] Overall, metastases have or will develop in up to 40% of individuals with UPS. […] In a review study conducted in China of 183 individuals with UPS reported that 7 (3.83%) individuals had a subtype of the paraneoplastic syndrome termed neoplastic fever, i.e. these individuals suffered continuous, disabling fevers. […] Fever symptoms disappeared in all patients after surgical removal of their tumors. It is suggested that individuals with UPS and neoplastic fever have a more favorable prognosis than individuals with UPS that do not evidence such fevers.

• #1 Undifferentiated Pleomorphic Sarcoma – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK570612/

  The undifferentiated pleomorphic sarcoma (UPS) typically appears as an asymptomatic, unremarkable, rapidly growing cutaneous or subcutaneous nodule without superficial skin abnormalities. […] Internal, intrathoracic, and intraabdominal UPS may show mass effect and/or constitutional symptoms. […] In a recent retrospective analysis of 100 UPS cases, the extremities were the most commonly involved location (55%), followed by the trunk (35%), retroperitoneum (9%), and the left atrium (1%). […] In another series of 266 cases, the average tumor size was 8.8 +/- 6.6 cm. […] In radiation-associated UPS, the median latency time between radiation and tumor development was 9.33 +/- 1.31 years. […] Early disease recognition and an adequate treatment strategy are the most important interventions to improve overall prognosis.

• #1 Undifferentiated Pleomorphic Sarcoma – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK570612/

  In a current retrospective study of 319 patients from three tertiary care centers, recurrences and metastases occurred in 14.1% and 7.8% of the cases, respectively. […] The recurrence risk was significantly increased with preoperative tumors greater than 5 cm, invasion beyond the subcutaneous fat, and advanced AJCC staging. […] Besides these, metastasis risk was also significantly increased in 2-5 cm tumors and those with lymphatic or vascular invasion. […] The 5- and 10-year overall survival rates were 60% and 48%, respectively. […] Interestingly, in another publication, the 5-year disease-specific survival and recurrence rates were significantly worse in radiation-associated UPS than sporadic UPS, suggesting there might be distinct mutational profiles for the disease. […] Follow-up visits are important to detect local recurrences or metastasis.

• #1 Undifferentiated Pleomorphic Sarcoma | Sarcoma UK

  https://sarcoma.org.uk/about-sarcoma/what-is-sarcoma/types-of-sarcoma/undifferentiated-pleomorphic-sarcoma/

  Undifferentiated pleomorphic sarcoma, also known as UPS, is one of the most common types of sarcoma. […] Symptoms of UPS can vary depending on the size and location of your tumour. You may experience all, some or none of these symptoms before you are diagnosed with UPS: A lump or swelling within the soft tissue of the body, which can occur anywhere in the body. This lump is often fast-growing and painful. […] UPS can reappear in the same area after the treatment of a previous tumour; this is called a local recurrence. […] A recurrence of UPS may be accompanied by cancer in other parts of the body. This is called metastasis or secondary cancer. Some people are diagnosed with sarcoma because their metastases have been discovered before their primary UPS tumour. In UPS patients, these secondary cancers may appear in the lungs, which is why a chest x-ray is taken at follow-up appointments.

• #1 Orphanet: Undifferentiated pleomorphic sarcoma

  https://www.orpha.net/en/disease/detail/2023

  An aggressive sarcoma of soft tissues or bone that can arise from any part of the body, clinically presenting as swelling, mass, pain, pathological fracture and occasional systemic features and is characterized by high local recurrence and significant metastasis. […] Patients may present pain, swelling / mass and pathological fractures. In the skin, UPS presents as a relatively painless, rapidly enlarging nodule. Anorexia, malaise, fever and weight loss are present in retroperitoneal and inflammatory forms of UPS. […] Most UPS recur locally; distant metastases are common (the most frequent is lung). Regional metastases are rare. […] A 5-year overall survival rate of 48% has been reported for patients with head and neck tumors versus 77% for patients with tumors arising on the trunk and extremities. The childhood variant appears have better prognosis.

• #1 Undifferentiated Pleomorphic Sarcoma: Causes, Symptoms and Treatment | Apollo Hospitals

  https://www.apollohospitals.com/diseases-and-conditions/undifferentiated-pleomorphic-sarcoma-causes-symptoms-and-treatment/

  Overall survival rates 5 years after diagnosis are approximately 60 percent. Like all forms of cancer, early detection causes better outcomes. Tumours that are bigger than 10 centimetres, grow deep in the muscle and are high grade (most aggressive form) have highest risk for cancer spread. […] Yes. Although rare, there are chances that undifferentiated pleomorphic sarcoma may recur after surgery. Get yourself checked regularly to catch the sarcoma at its onset.

• #1 Undifferentiated Pleomorphic Sarcoma: Causes, Symptoms and Treatment | Apollo Hospitals

  https://www.apollohospitals.com/diseases-and-conditions/undifferentiated-pleomorphic-sarcoma-causes-symptoms-and-treatment/

  The symptoms of undifferentiated pleomorphic sarcoma depend on its location (where it has grown) and the size of the lump. It generally affects the arms and legs but may occur in any part of the body. Some of the symptoms that may appear are: […] Growing lump or swelling in the area affected […] Pain, tingling or numbness where the cancer is growing […] Loss of appetite […] Diarrhea or constipation if it occurs in the abdominal region […] Fever and chills […] Unexpected weight loss […] Pain in the bones. […] Undifferentiated pleomorphic sarcoma can be extremely aggressive and may require immediate treatment to stop it from growing. […] If left untreated, undifferentiated pleomorphic sarcoma may give rise to the following complications: […] Severe pain in the area affected […] Spreading of tumor to different parts of the body […] Damage to the blood vessels […] Pain, numbness or weakness in the body […] Death.

• #1 Spindle cell sarcoma | Sarcoma UK

  https://sarcoma.org.uk/about-sarcoma/what-is-sarcoma/types-of-sarcoma/spindle-cell-sarcoma/

  Symptoms of spindle cell sarcoma can vary depending on the size and location of your tumour. You may experience all, some or none of these symptoms before you are diagnosed with spindle cell sarcoma: […] A lump or swelling within the soft tissue of the body, which can occur anywhere in the body but most often in the arms and legs […] This lump is often fast-growing and painful. […] Spindle cell sarcoma can reappear in the same area after the treatment of a previous tumour; this is called a local recurrence. […] If the cancer does reappear, it is important to get treated as quickly as possible. […] A recurrence of spindle cell sarcoma may be accompanied by cancer in other parts of the body. This is called metastasis or secondary cancer. […] In spindle cell sarcoma patients, these secondary cancers may appear in the lungs, which is why a chest x-ray is taken at follow-up appointments.

• #1 Soft Tissue Sarcoma: Symptoms, Treatment & Prognosis

  https://my.clevelandclinic.org/health/diseases/21732-soft-tissue-sarcoma

  Many soft tissue sarcoma symptoms are similar to other, less serious conditions. You should contact a healthcare provider if you have: […] A new lump or a fast-growing lump anywhere on your body. […] A lump that starts to hurt. […] Belly pain that’s getting worse. […] Blood in your poop or poop that appears black. […] Nausea and vomiting. […] Losing weight without trying. […] Soft tissue sarcoma can be a serious medical issue. Like many forms of cancer, healthcare providers have more success treating soft tissue sarcomas if they diagnose the tumor before it spreads. Without treatment, soft tissue sarcomas may spread (metastasize) and affect other areas of your body.

• #2 Undifferentiated pleomorphic sarcoma – Symptoms and causes – Mayo Clinic

  https://www.mayoclinic.org/diseases-conditions/undifferentiated-pleomorphic-sarcoma/symptoms-causes/syc-20389554

  Undifferentiated pleomorphic sarcoma symptoms depend on where the cancer occurs. It most often happens in the arms and legs, but it can happen anywhere in the body. […] Signs and symptoms may include: […] Growing lump or area of swelling. […] If it grows very large, there may be pain, tingling and numbness. […] If it occurs in an arm or leg, there may be swelling in the hand or foot of an affected limb. […] If it occurs in the abdomen, there may be pain, loss of appetite and constipation. […] Fever. […] Weight loss.

• #2 Pleomorphic Sarcoma Los Angeles, CA | Daniel C Allison MD, FACS

  https://drallison.org/pleomorphic-sarcoma/

  The most common symptom/sign of a pleomorphic sarcoma is a rapidly growing, painless lump or mass. They can manifest rather quickly, and are often mistaken as a result of trauma. […] Pleomorphic sarcomas are usually not painful, unless they are pressing on a nerve or blood vessel.

• #2 Undifferentiated Pleomorphic Sarcoma | Orthopedic Surgery | Patient Care | Montefiore Einstein

  https://montefioreeinstein.org/patient-care/services/orthopedics/specialties/orthopedic-oncology/pleomorphic-sarcoma

  Patients will often note a sizable, growing, painless lump. Pain is sometimes reported, but often these lumps are not particularly uncomfortable, prompting some patients to delay seeking medical attention. […] These tumors can grow rapidly and often reach sizes between five and 15 centimeters in diameter or larger. As they enlarge, the overlying skin can appear taught or stretched. Deeper structures or organs can be compressed, leading to a constellation of symptoms, depending on what is being impacted.

• #2 Undifferentiated Sarcoma | Symptoms, Diagnosis & Treatment

  https://www.cincinnatichildrens.org/health/u/undifferentiated-sarcoma

  Symptoms of undifferentiated sarcoma vary according to the area of the body that is involved. Pain, tenderness or swelling in that area may be seen. When the tumor gets large enough, it may start to press on other organs and cause swelling, pain or compression (blockage). […] If other organs are compressed, they may not work as well as they should. For example, if a sarcoma occurs in the abdomen, it may press down on the intestines and cause constipation. Or if the tumor occurs in the lungs, it may cause breathing difficulty. The tumor may cause compression on the nerves, resulting in feelings of numbness, tingling or muscle weakness.

• #2 Soft tissue sarcoma in the leg: Symptoms and more

  https://www.medicalnewstoday.com/articles/soft-tissue-sarcoma-leg

  Most people with STS experience swelling or a lump that continues to grow for weeks or months. This lump may be present in the leg. […] STS in the leg can cause a lump that: feels painful or tender, continues to get bigger, grows larger than 2 inches, or about the size of a golf ball. […] The lump may feel painful or tender, or it may be painless. Over a period of weeks or months, it may grow to be bigger than 2 inches, about the size of a golf ball. […] STS in the leg may grow over a period of weeks to months. The growth rate of STS varies from case to case it can grow quickly or slowly. […] The main symptom of STS in the leg is swelling or a lump in the area. The lump may be painless or feel tender and may continue growing for weeks or months.

• #2 Undifferentiated pleomorphic sarcoma // Middlesex Health

  https://middlesexhealth.org/learning-center/diseases-and-conditions/undifferentiated-pleomorphic-sarcoma

  Undifferentiated pleomorphic sarcoma symptoms depend on where the cancer occurs. It most often happens in the arms and legs, but it can happen anywhere in the body. […] Signs and symptoms may include: Growing lump or area of swelling. If it grows very large, there may be pain, tingling and numbness. If it occurs in an arm or leg, there may be swelling in the hand or foot of an affected limb. If it occurs in the abdomen, there may be pain, loss of appetite and constipation. Fever. Weight loss.

• #2 Mayo Clinic Health Library – Undifferentiated pleomorphic sarcoma | Swiss Medical Network

  https://www.swissmedical.net/en/healtcare-library/con-20344525

  Undifferentiated pleomorphic sarcoma symptoms depend on where the cancer occurs. It most often happens in the arms and legs, but it can happen anywhere in the body. […] Signs and symptoms may include: […] Growing lump or area of swelling. […] If it grows very large, there may be pain, tingling and numbness. […] If it occurs in an arm or leg, there may be swelling in the hand or foot of an affected limb. […] If it occurs in the abdomen, there may be pain, loss of appetite and constipation. […] Fever. […] Weight loss.

• #2 Undifferentiated Pleomorphic Sarcoma: Causes, Symptoms and Treatment | Apollo Hospitals

  https://www.apollohospitals.com/diseases-and-conditions/undifferentiated-pleomorphic-sarcoma-causes-symptoms-and-treatment/

  The symptoms of undifferentiated pleomorphic sarcoma depend on its location (where it has grown) and the size of the lump. It generally affects the arms and legs but may occur in any part of the body. Some of the symptoms that may appear are: […] Growing lump or swelling in the area affected […] Pain, tingling or numbness where the cancer is growing […] Loss of appetite […] Diarrhea or constipation if it occurs in the abdominal region […] Fever and chills […] Unexpected weight loss […] Pain in the bones. […] Undifferentiated pleomorphic sarcoma can be extremely aggressive and may require immediate treatment to stop it from growing. […] If left untreated, undifferentiated pleomorphic sarcoma may give rise to the following complications: […] Severe pain in the area affected […] Spreading of tumor to different parts of the body […] Damage to the blood vessels […] Pain, numbness or weakness in the body […] Death.

• #2 High-grade Undifferentiated Pleomorphic Sarcoma | Applied Radiology

  https://appliedradiology.com/articles/high-grade-undifferentiated-pleomorphic-sarcoma

  A 51-year-old presented to the emergency department with a non-productive cough and intermittent hemoptysis of one-month duration. Additional symptoms included progressive dyspnea, night sweats, and a 25-pound unintentional weight loss over the previous six months. The typical presenting signs and symptoms of pulmonary artery sarcoma are nonspecific and include dyspnea, chest pain, hemoptysis, and cough. By the time patients develop symptoms, the disease is locally advanced or metastatic which, in combination with the tumors inherent aggressiveness, confers a poor prognosis. […] Although pulmonary artery sarcoma is rare compared to pulmonary artery embolism, the diagnosis should be considered in atypical clinical and imaging presentations, as prompt diagnosis is essential for prolonged survival.

• #2 An unusual case of metastasis of a pulmonary undifferentiated pleomorphic sarcoma to the right ventricle: a case report | Journal of Medical Case Reports | Full Text

  https://jmedicalcasereports.biomedcentral.com/articles/10.1186/1752-1947-7-165

  Undifferentiated pleomorphic sarcoma is defined as a pleomorphic high-grade sarcoma whose line of differentiation cannot be determined. Symptoms of cardiac neoplasms usually appear late in the course of the disease and are often ignored because of the more severe effects of the primary malignant disorder or its therapy. […] We present the case of a patient with undifferentiated pleomorphic sarcoma of the lung presenting with symptomatic right-heart failure secondary to cardiac metastasis. […] Our patient was a 59-year-old Chinese woman with symptomatic metastasis of an undifferentiated pleomorphic sarcoma of the lung to the right ventricle. […] She underwent surgical excision of the cardiac mass because it caused dyspnea and posed a high risk of sudden death, pulmonary embolism or tricuspid obstruction.

• #2 Undifferentiated Pleomorphic Sarcoma – SFA

  https://curesarcoma.org/sarcoma-subtypes/undifferentiated-pleomorphic-sarcoma/

  Undifferentiated pleomorphic sarcoma is a rare, high-grade bone tumor characterized by pleomorphic cells and a lack of specific differentiation, often diagnosed by exclusion. […] Symptomatic patients typically report pain and occasionally swelling. Pathological fractures are common, particularly in weight-bearing long tubular bones. […] Patients with localized disease and adequate therapy have a 5-year survival rate of 50–67%. Pulmonary metastases are common, occurring in approximately 35–50% of cases. Secondary UPS and metastatic disease are associated with a poorer prognosis. Incomplete expression of myogenic markers is not thought to affect the prognosis.

• #2 Undifferentiated pleomorphic sarcoma | About the Disease | GARD

  https://rarediseases.info.nih.gov/diseases/6963/undifferentiated-pleomorphic-sarcoma

  Many rare diseases have limited information. Currently, GARD aims to provide the following information for this disease: […] Symptoms may start to appear at a variety of ages. […] Symptoms of this disease may start to appear at a variety of ages. […] The types of symptoms experienced, and their intensity, may vary among people with this disease. Your experience may be different from others. Consult your health care team for more information. […] The following describes the symptom(s) associated with this disease along with the corresponding body system(s), description, synonyms, and frequency (Note: Not all possible symptoms may be listed): […] Weight Loss […] Fatigue […] Fever […] Anorexia […] Abnormality of The Lower Limb […] Abnormality of The Musculature […] Abnormality of The Upper Limb […] Abnormal peritoneum morphology […] Soft tissue sarcoma

• #2 Orphanet: Undifferentiated pleomorphic sarcoma

  https://www.orpha.net/en/disease/detail/2023

  An aggressive sarcoma of soft tissues or bone that can arise from any part of the body, clinically presenting as swelling, mass, pain, pathological fracture and occasional systemic features and is characterized by high local recurrence and significant metastasis. […] Patients may present pain, swelling / mass and pathological fractures. In the skin, UPS presents as a relatively painless, rapidly enlarging nodule. Anorexia, malaise, fever and weight loss are present in retroperitoneal and inflammatory forms of UPS. […] Most UPS recur locally; distant metastases are common (the most frequent is lung). Regional metastases are rare. […] A 5-year overall survival rate of 48% has been reported for patients with head and neck tumors versus 77% for patients with tumors arising on the trunk and extremities. The childhood variant appears have better prognosis.

• #2 Sarcoma Awareness Month 2024: Recognizing Symptoms, Scanning Patients Key to Diagnosis

  https://www.onclive.com/view/sarcoma-awareness-month-2024-recognizing-symptoms-scanning-patients-key-to-diagnosis

  Sarcoma symptoms typically manifest as a mass or lump and may cause tingling or, according to Adam C. Berger, MD, FACS, who added early diagnosis of sarcoma remains a challenge since symptoms may not present until the tumor is large enough. […] The biggest challenge is that they often grow for long periods of time before any symptoms happen. There is no routine surveillance or screening that’s done for sarcoma, especially since they’re so rare. […] Oftentimes, sarcomas are diagnosed later because they have to grow to a certain point to cause any symptoms. […] Occasionally, there will be pain associated with [sarcomas]. However, a lot of times, they grow slowly, and they’re deep, so they don’t get noticed early. They get noticed when they grow big enough that somebody can feel them. I’d say the most common symptoms are feeling a mass or sometimes feeling pain.

• #2 Undifferentiated Pleomorphic Sarcoma – MD Searchlight

  https://mdsearchlight.com/cancer/undifferentiated-pleomorphic-sarcoma/

  Undifferentiated pleomorphic sarcoma (UPS) usually shows up as a painless, rapidly growing lump under the skin or on the surface of the skin without any visible skin changes. […] If UPS forms inside the body, in the chest, or in the stomach area, it might cause symptoms due to the growing mass. There might also be general body symptoms like fever or weight loss. […] In a recent review of 100 UPS cases, most tumors were found in the arms or legs (55%), followed by the torso or trunk (35%), behind the stomach area (9%), and in the left upper chamber of the heart (1%). […] The average tumor size is approximately 8.8 cm. […] If UPS is related to previous radiation therapy, it usually takes about 9.33 years for the tumor to develop after the radiation treatment.

• #2 Undifferentiated Pleomorphic Sarcoma | Sarcoma UK

  https://sarcoma.org.uk/about-sarcoma/what-is-sarcoma/types-of-sarcoma/undifferentiated-pleomorphic-sarcoma/

  Undifferentiated pleomorphic sarcoma, also known as UPS, is one of the most common types of sarcoma. […] Symptoms of UPS can vary depending on the size and location of your tumour. You may experience all, some or none of these symptoms before you are diagnosed with UPS: A lump or swelling within the soft tissue of the body, which can occur anywhere in the body. This lump is often fast-growing and painful. […] UPS can reappear in the same area after the treatment of a previous tumour; this is called a local recurrence. […] A recurrence of UPS may be accompanied by cancer in other parts of the body. This is called metastasis or secondary cancer. Some people are diagnosed with sarcoma because their metastases have been discovered before their primary UPS tumour. In UPS patients, these secondary cancers may appear in the lungs, which is why a chest x-ray is taken at follow-up appointments.

• #2 Undifferentiated Pleomorphic Sarcoma – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK570612/

  In a current retrospective study of 319 patients from three tertiary care centers, recurrences and metastases occurred in 14.1% and 7.8% of the cases, respectively. […] The recurrence risk was significantly increased with preoperative tumors greater than 5 cm, invasion beyond the subcutaneous fat, and advanced AJCC staging. […] Besides these, metastasis risk was also significantly increased in 2-5 cm tumors and those with lymphatic or vascular invasion. […] The 5- and 10-year overall survival rates were 60% and 48%, respectively. […] Interestingly, in another publication, the 5-year disease-specific survival and recurrence rates were significantly worse in radiation-associated UPS than sporadic UPS, suggesting there might be distinct mutational profiles for the disease. […] Follow-up visits are important to detect local recurrences or metastasis.

• #2

  https://www.navigatingcare.com/library/bone-osteo/learn/general-information-about-osteosarcoma-and-undifferentiated-pleomorphic-sarcoma-ups-formerly-called-malignant-fibrous-histiocytoma-mfh-of-bone

  Signs and symptoms of osteosarcoma and UPS include swelling over a bone or a bony part of the body and joint pain. […] These and other signs and symptoms may be caused by osteosarcoma or UPS or by other conditions. Check with a doctor if your child has any of the following: […] Swelling over a bone or bony part of the body. […] Pain in a bone or joint. […] A bone that breaks for no known reason. […] The prognosis of untreated osteosarcoma and UPS may depend on the following: […] Where the tumor is in the body and whether tumors formed in more than one bone. […] Whether the patient has two or more tumors in the same bone. […] The size of the tumor. […] Whether the cancer has spread to other parts of the body and where it has spread. […] The type of tumor (based on how the cancer cells look under a microscope).

• #2

  https://www.orthobullets.com/pathology/8064/undifferentiated-pleomorphic-sarcoma

  Undifferentiated Pleomorphic Sarcoma, previously known as malignant fibrous histiocytoma, is a high-grade, aggressive, malignant fibrogenic tumor. […] The condition is typically seen in patients 55-80 years of age who present with a slow-growing, painless mass. […] Symptoms may present with fever. […] Common symptoms include a slow-growing, painless mass. […] Physical exam may reveal a painless soft tissue mass that may be palpable. […] Mass effect may cause neurovascular symptoms. […] 50-60% 5-year survival.

• #2 Childhood Soft Tissue Sarcoma – NCI

  https://www.cancer.gov/types/soft-tissue-sarcoma/patient/child-soft-tissue-treatment-pdq

  Soft tissue sarcoma may appear as a painless lump under the skin, often on an arm, a leg, the chest, or the abdomen. There may be no other symptoms at first. As the sarcoma gets bigger and presses on nearby organs, nerves, muscles, or blood vessels, it may cause symptoms, such as pain or weakness. Fever, weight loss, night sweats, and low or high blood sugar levels are rare symptoms. […] Undifferentiated pleomorphic sarcoma (malignant fibrous histiocytoma). This type of soft tissue tumor may form in parts of the body where people have received radiation therapy in the past, or as a second cancer in children with retinoblastoma. The cancer usually forms in the arms or legs and may spread to other parts of the body. […] Treatment of newly diagnosed undifferentiated pleomorphic sarcoma may include surgery. Treatment of recurrent or refractory undifferentiated pleomorphic sarcoma may include immunotherapy (pembrolizumab).

• #2 Undifferentiated Pleomorphic Sarcoma: Causes, Symptoms and Treatment | Apollo Hospitals

  https://www.apollohospitals.com/diseases-and-conditions/undifferentiated-pleomorphic-sarcoma-causes-symptoms-and-treatment/

  Overall survival rates 5 years after diagnosis are approximately 60 percent. Like all forms of cancer, early detection causes better outcomes. Tumours that are bigger than 10 centimetres, grow deep in the muscle and are high grade (most aggressive form) have highest risk for cancer spread. […] Yes. Although rare, there are chances that undifferentiated pleomorphic sarcoma may recur after surgery. Get yourself checked regularly to catch the sarcoma at its onset.

• #2 Cancer of the Connective Tissues: Soft-Tissue Sarcoma | HSS

  https://www.hss.edu/condition-list_soft-tissue-sarcoma.asp

  Patients usually notice an enlarging mass or lump in the arm or leg. […] The mass is usually painless, leading many to ignore it until it reaches substantial size. […] If the mass presses on a nearby nerve, it may lead to numbness or tingling in an extremity. […] The growth rate of soft-tissue sarcoma is highly variable, but in general it will grow noticeably over weeks to months. […] Any mass that grows in this time frame needs urgent medical evaluation. […] Even a mass that grows slowly over years should still be evaluated to determine if cancer is present.

• #3 Soft Tissue Sarcomas of the Leg: Symptoms, Treatment, Outlook

  https://www.healthline.com/health/cancer/what-to-know-about-soft-tissue-sarcomas-in-the-leg

  The main symptoms of soft tissue sarcomas include: a growing, painless lump […] progressive pain or soreness as it pushes on other tissue. […] Sarcomas in one of your joints might cause: restricted movement […] trouble walking.

• #3 Soft Tissue Sarcoma: Causes, Symptoms And Treatment

  https://www.netmeds.com/health-library/post/soft-tissue-sarcoma-causes-symptoms-and-treatment?srsltid=AfmBOorc_siOE83yRJtgg5OVS5jgDV3UaZQJPE_XfEXsscNiLYeoEe-T

  The characteristic signs and symptoms of Soft tissue sarcoma include: […] Formation of a new, noticeable, painless lump anywhere on the body […] Swelling under the skin that grows larger with time and hurts […] Formation of a lump near the lungs that might cause incessant cough or a feeling of breathlessness […] Pain in different parts of the body arising due to the pressure from tumours on the nerves […] Swelling in the stomach […] Abdominal pain […] Constipation […] Feeling full all the time […] Excessive fatigue […] General debility […] Nausea and vomiting […] Sudden weight loss without trying.

• #3 Spindle Cell Sarcoma Symptoms & Treatment | Baptist Health

  https://www.baptisthealth.com/care-services/conditions-treatments/spindle-cell-sarcoma

  Spindle cell sarcoma can form in any bone of the body, which makes symptoms dependent on the individual and the location and type of spindle cell sarcoma. Often, symptoms of spindle cell sarcoma are common to other conditions, making it difficult to diagnose early on. Symptoms include: […] Bone pain that can come and go […] Pathological bone fracture due to weakening of the bone from the disease […] Swelling […] Tenderness or soreness […] Appearance of a lump or mass […] Reduced mobility in the affected area, or in a nearby joint […] Fatigue […] Malaise.

• #3

  https://www.orthobullets.com/pathology/8030/pleomorphic-sarcoma-of-bone-malignant-fibrous-histiocytoma

  Pleomorphic Sarcoma of Bone, formerly known as Malignant Fibrous Histiocytoma, are rare malignant histiocytic lesions of bone most commonly found in the metaphysis of long bones. Patients typically present between the ages of 20 to 80 with painful, regional masses. […] Symptoms include pain and constitutional symptoms such as fevers, chills, night sweats, and weight loss. […] History may include a new, painful mass that can present with a pathologic fracture. […] Physical examination may reveal swelling, a limp, and decreased range of motion. […] 50% – 60% survival at 5 years. […] Worse prognosis with secondary MFH compared to primary lesions. […] Pulmonary metastasis common in up to 30%. […] Good response (90% tumor necrosis) to neoadjuvant chemotherapy found to have a much better prognosis. […] Age younger than 40 years associated with improved disease-free survival rate.

• #3 Sarcoma – symptoms, causes, diagnosis and treatment in the best clinics – MedTour

  https://medtour.help/disease/sarcoma/

  At an early stage, a sarcoma may look like a small lump and induration. Often, the growth is painful and causes swelling around the affected area. In some cases, the skin over the tumor becomes red or, on the contrary, pale, its texture changes. If the neoplasm compresses nearby nerves, the area of its localization may become numb. […] The rate of development of the disease depends on the type of tumor. The most aggressive forms grow rapidly, reaching 10 cm in diameter in just one month. Other types may develop slowly, going unnoticed for a long time. […] Undifferentiated pleomorphic sarcoma (NPS) is an aggressive type of tumor that often metastasizes or recurs after treatment. Most often occurs in people aged 50-70 years.

• #3 Orphanet: Undifferentiated pleomorphic sarcoma

  https://www.orpha.net/en/disease/detail/2023

  An aggressive sarcoma of soft tissues or bone that can arise from any part of the body, clinically presenting as swelling, mass, pain, pathological fracture and occasional systemic features and is characterized by high local recurrence and significant metastasis. […] Patients may present pain, swelling / mass and pathological fractures. In the skin, UPS presents as a relatively painless, rapidly enlarging nodule. Anorexia, malaise, fever and weight loss are present in retroperitoneal and inflammatory forms of UPS. […] Most UPS recur locally; distant metastases are common (the most frequent is lung). Regional metastases are rare. […] A 5-year overall survival rate of 48% has been reported for patients with head and neck tumors versus 77% for patients with tumors arising on the trunk and extremities. The childhood variant appears have better prognosis.

• #3 Undifferentiated pleomorphic sarcomas of the proximal femur, A case study

  https://meddocsonline.org/journal-of-case-reports-and-medical-images/Undifferentiated-pleomorphic-sarcomas-of-the-proximal-femur-A-case-study.html

  Pleomorphic sarcomas are a subtype of soft tissue sarcomas occurring most commonly in the proximal thigh, with a male preponderance, common in 7th and 8th decades of life. It is a locally invasive tumour with a wide clinical presentation. […] Undifferentiated pleomorphic sarcoma usually occurs in older adults, and often men account for two thirds of cases. Initially the nature of the tumor is benign, but soon becomes locally malignant leading to wide variety in its presentation, and thus a form of a diagnostic challenge. […] Clinical features of a long bone tumour like a pleomorphic sarcoma, has wide range of presentation, and the symptoms dont show up until the late disease process, ranging from deep aching, gnawing bone pain, to involvement of the nerves, most commonly on the posterolateral surface resulting in numbness and tingling in the posterior aspect of the thigh, calf and foot, or sciatica, to pathological fractures, which often lead to a quick discovery of the tumour.

• #4 Undifferentiated Pleomorphic Sarcoma – StatPearls – NCBI Bookshelf

  https://www.ncbi.nlm.nih.gov/books/NBK570612/

  In a current retrospective study of 319 patients from three tertiary care centers, recurrences and metastases occurred in 14.1% and 7.8% of the cases, respectively. […] The recurrence risk was significantly increased with preoperative tumors greater than 5 cm, invasion beyond the subcutaneous fat, and advanced AJCC staging. […] Besides these, metastasis risk was also significantly increased in 2-5 cm tumors and those with lymphatic or vascular invasion. […] The 5- and 10-year overall survival rates were 60% and 48%, respectively. […] Interestingly, in another publication, the 5-year disease-specific survival and recurrence rates were significantly worse in radiation-associated UPS than sporadic UPS, suggesting there might be distinct mutational profiles for the disease. […] Follow-up visits are important to detect local recurrences or metastasis.

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