Niealergiczne zapalenie błony śluzowej nosa
Leczenie
Niealergiczny nieżyt nosa (NNN) wymaga indywidualnego podejścia terapeutycznego, zależnego od nasilenia objawów i ich wpływu na codzienne funkcjonowanie pacjenta. Podstawą leczenia jest unikanie czynników wyzwalających, takich jak dym tytoniowy, silne zapachy, zanieczyszczenia powietrza czy gwałtowne zmiany temperatury. Farmakoterapia opiera się głównie na donosowych kortykosteroidach (flutikazon, beklometazon, mometazon, triamcynolon), które wykazują wysoką skuteczność w łagodzeniu obrzęku śluzówki, uczucia zatkania nosa, spływania wydzieliny po tylnej ścianie gardła, kichania i świądu, z efektem pojawiającym się po 24-72 godzinach i utrzymującym się podczas stosowania. Donosowe leki przeciwhistaminowe (azelastyna, olopatadyna) oraz ipratropium bromek (0,03% lub 0,06%) są szczególnie skuteczne w leczeniu wodnistego wycieku z nosa, natomiast dekongestanty (pseudoefedryna, fenylefryna, oksymetazolina) stosowane krótkotrwale (3-5 dni) redukują obrzęk błony śluzowej, jednak ich długotrwałe użycie wiąże się z ryzykiem polekowego nieżytu nosa i działań niepożądanych, takich jak podwyższone ciśnienie krwi czy kołatanie serca.
- Nieallergiczny nieżyt nosa – przegląd metod leczenia
- Metody farmakoterapii w nieallergicznym nieżycie nosa
- Kortykosteroidy donosowe
- Donosowe leki przeciwhistaminowe
- Ipratropium bromek
- Leki obkurczające naczynia krwionośne (dekongestanty)
- Leczenie skojarzone
- Metody niefarmakologiczne w leczeniu nieallergicznego nieżytu nosa
- Nowe metody leczenia
- Leczenie chirurgiczne
- Leczenie w populacjach szczególnych
- Kompleksowe podejście do leczenia
- Porównanie skuteczności różnych metod leczenia
Nieallergiczny nieżyt nosa – przegląd metod leczenia
Leczenie nieallergicznego nieżytu nosa (NNN) zależy przede wszystkim od nasilenia objawów i stopnia, w jakim wpływają one na codzienne funkcjonowanie pacjenta. Przy łagodnych przypadkach wystarczające może być unikanie czynników wyzwalających i stosowanie domowych metod leczenia, natomiast bardziej uciążliwe objawy mogą wymagać farmakoterapii lub nawet interwencji chirurgicznej12. Należy podkreślić, że nieallergiczny nieżyt nosa jest schorzeniem, którego nie można całkowicie wyleczyć, ale można skutecznie kontrolować jego objawy34.
Unikanie czynników wyzwalających
Pierwszą linią postępowania terapeutycznego w nieallergicznym nieżycie nosa jest identyfikacja i unikanie czynników wyzwalających objawy56. Do najczęstszych czynników wywołujących objawy należą:
- Dym tytoniowy i inne rodzaje dymu
- Silne zapachy, perfumy, środki czystości
- Zanieczyszczenia powietrza
- Gwałtowne zmiany temperatury i wilgotności
- Niektóre pokarmy i napoje (w przypadku nieżytu gustatoryjnego)
W przypadku, gdy nieżyt nosa jest wywoływany przez przyjmowane leki, warto skonsultować się z lekarzem w celu rozważenia zmiany terapii8.
Metody farmakoterapii w nieallergicznym nieżycie nosa
Kortykosteroidy donosowe
Donosowe kortykosteroidy są uznawane za złoty standard w leczeniu nieallergicznego nieżytu nosa910. Leki te zmniejszają stan zapalny błony śluzowej nosa i mogą być skuteczne przy takich objawach jak obrzęk śluzówki, uczucie zatkania nosa, spływanie wydzieliny po tylnej ścianie gardła, kichanie i świąd11. W Stanach Zjednoczonych tylko flutikazon i beklometazon są oficjalnie zatwierdzone przez FDA do leczenia nieallergicznego nieżytu nosa11.
Należy pamiętać, że kortykosteroidy donosowe mogą wymagać od 24 do 72 godzin przed pojawieniem się pierwszych efektów, a pełny efekt terapeutyczny może być widoczny dopiero po kilku dniach lub tygodniach regularnego stosowania811. Do najczęściej stosowanych kortykosteroidów donosowych należą:
- Flutikazon (Flonase)
- Beklometazon
- Mometazon (Nasonex)
- Triamcynolon (Nasacort)
Warto zauważyć, że niektóre podgrupy pacjentów z nieallergicznym nieżytem nosa mogą nie reagować na kortykosteroidy donosowe, szczególnie osoby, u których objawy są wywoływane głównie przez zmiany pogody i temperatury9. Potencjalne działania niepożądane obejmują suchość nosa lub gardła, krwawienia z nosa i bóle głowy13.
Donosowe leki przeciwhistaminowe
Donosowe leki przeciwhistaminowe mogą być skuteczne w leczeniu nieallergicznego nieżytu nosa, mimo że nie jest on wywołany alergią9. Ich działanie polega na blokowaniu stanu zapalnego i neurorozapalnego w błonie śluzowej nosa9. Leki te mogą przynieść szybką ulgę w objawach takich jak spływanie wydzieliny po tylnej ścianie gardła, obrzęk śluzówki i kichanie8.
Do najczęściej stosowanych donosowych leków przeciwhistaminowych należą:
- Azelastyna (Astelin, Astepro) – jedyny lek przeciwhistaminowy zatwierdzony przez FDA do leczenia nieżytu naczyniowo-ruchowego (vasomotor rhinitis)14
- Olopatadyna (Patanase)15
Warto zwrócić uwagę, że doustne leki przeciwhistaminowe nie są tak skuteczne w leczeniu nieallergicznego nieżytu nosa jak w przypadku nieżytu alergicznego1216.
Ipratropium bromek
Ipratropium bromek (Atrovent) to lek o działaniu przeciwcholinergicznym, który jest szczególnie skuteczny w przypadku, gdy dominującym objawem jest wodnisty wyciek z nosa (rhinorrhea)117. Jest on zalecany zwłaszcza w przypadku nieżytu gustatoryjnego, czyli wodnistego wycieku z nosa wywołanego spożywaniem niektórych pokarmów i napojów1819.
Ipratropium bromek blokuje receptory parasympatyczne, co prowadzi do zmniejszenia wydzielania śluzu w nosie6. Jest dostępny w stężeniach 0,03% lub 0,06%619. Jego stosowanie może powodować działania niepożądane takie jak krwawienia z nosa i suchość w nosie1.
Badania wykazały, że stosowanie ipratropium bromku w połączeniu z kortykosteroidami donosowymi jest bardziej skuteczne niż stosowanie każdego z tych leków osobno, szczególnie w leczeniu wodnistego wycieku z nosa6.
Leki obkurczające naczynia krwionośne (dekongestanty)
Dekongestanty pomagają zmniejszyć obrzęk błony śluzowej nosa poprzez zwężenie naczyń krwionośnych, co prowadzi do zmniejszenia uczucia zatkania nosa13. Mogą być stosowane doustnie lub miejscowo w postaci spray’ów donosowych.
Do najczęściej stosowanych dekongestantów należą:
Należy jednak pamiętać, że dekongestanty powinny być stosowane krótkotrwale (nie dłużej niż 3-5 dni w przypadku preparatów donosowych), ponieważ dłuższe stosowanie może prowadzić do wystąpienia efektu z odbicia (nasilenie objawów po odstawieniu leku) i rozwoju polekowego nieżytu nosa (rhinitis medicamentosa)1820. Ponadto, mogą wywoływać działania niepożądane takie jak podwyższone ciśnienie krwi, kołatanie serca i niepokój13.
Leczenie skojarzone
W przypadku, gdy monoterapia nie przynosi wystarczającej ulgi w objawach, można zastosować leczenie skojarzone. Badania wykazały, że połączenie kortykosteroidu donosowego z donosowym lekiem przeciwhistaminowym jest bardziej skuteczne niż każdy z tych leków stosowany osobno917.
Na rynku dostępny jest preparat Dymista, który zawiera zarówno azelastynę, jak i flutikazon2122. Takie połączenie może być szczególnie korzystne dla pacjentów, u których objawy nie są wystarczająco kontrolowane przy zastosowaniu monoterapii17.
Metody niefarmakologiczne w leczeniu nieallergicznego nieżytu nosa
Płukanie nosa roztworem soli fizjologicznej
Płukanie nosa roztworem soli fizjologicznej (irygacja nosa) jest prostą, ale skuteczną metodą leczenia nieallergicznego nieżytu nosa517. Metoda ta polega na przepłukiwaniu jam nosowych roztworem soli fizjologicznej, co pomaga usunąć drażniące substancje i nadmiar śluzu, nawilża błonę śluzową nosa oraz łagodzi stan zapalny12.
Do płukania nosa można używać:
- Gotowych spray’ów z solą fizjologiczną
- Dzbanuszków do płukania nosa (tzw. neti pot)
- Specjalnie zaprojektowanych buteleczek ze ściśliwymi ściankami
Płukanie nosa jest szczególnie pomocne w przypadku spływania wydzieliny po tylnej ścianie gardła (post-nasal drip)18. Warto pamiętać, że zgodnie z zaleceniami CDC, do przygotowania roztworu do płukania nosa należy używać wody destylowanej, sterylnej lub przegotowanej, aby uniknąć ryzyka infekcji23.
Nawilżanie powietrza
Nawilżanie powietrza może być pomocne w łagodzeniu objawów nieallergicznego nieżytu nosa, szczególnie w przypadku, gdy jest on wywoływany przez suche powietrze24. Użycie nawilżacza powietrza może pomóc utrzymać odpowiednią wilgotność w pomieszczeniu, co zmniejsza suchość i podrażnienie błony śluzowej nosa24.
Nowe metody leczenia
Krioterapia (terapia zimnem)
Krioterapia (ClariFix) to innowacyjna, minimalnie inwazyjna metoda leczenia nieallergicznego nieżytu nosa25. Polega ona na użyciu endoskopu i urządzenia do krioterapii w celu zamrożenia nerwów w jamach nosowych, które są odpowiedzialne za nadmierną produkcję wydzieliny2526.
Zabieg ten przeprowadza się w gabinecie lekarskim, w znieczuleniu miejscowym i trwa zazwyczaj kilka minut27. ClariFix może zapewnić ulgę w objawach takich jak wodnisty wyciek z nosa i uczucie zatkania nosa przez okres do roku lub dłużej2528.
Badania kliniczne wykazały, że cztery na pięć osób zgłaszało długotrwałą poprawę po zabiegu ClariFix, w tym zmniejszenie kataru i uczucia zatkanego nosa28. Poprawa objawów zazwyczaj następuje między 7 a 30 dniem po zabiegu, a wyniki utrzymują się przez co najmniej rok28.
Terapia niską temperaturą fal radiowych (RhinAer)
RhinAer to kolejna nowoczesna metoda leczenia nieallergicznego nieżytu nosa, która została zatwierdzona przez FDA w 2020 roku29. W przeciwieństwie do ClariFix, który wykorzystuje ciekły azot do zamrażania tkanki nerwowej, RhinAer używa fal radiowych o niskiej temperaturze do zakłócenia włókien nerwowych związanych z wywoływaniem kataru29.
Procedura RhinAer jest minimalnie inwazyjna i może być przeprowadzana w gabinecie lekarskim30. Zapewnia ona długotrwałą ulgę w objawach przewlekłego nieżytu nosa, takich jak wodnisty wyciek z nosa, spływanie wydzieliny po tylnej ścianie gardła i uczucie zatkania nosa30.
Dodatkowe korzyści wynikające z zabiegu RhinAer obejmują poprawę jakości snu, zmniejszenie ryzyka infekcji zatok, zmniejszenie senności w ciągu dnia, poprawę koncentracji i lepszą zdolność radzenia sobie ze stresem31.
Kapsaicyna
Kapsaicyna, aktywny składnik papryczek chili, podawana donosowo, jest uważana za jedną z opcji leczenia nieallergicznego nieżytu nosa32. Działa ona poprzez odczulanie nerwów w nosie i zmniejszanie objawów takich jak uczucie zatkania nosa i wodnisty wyciek z nosa33.
Badania wykazały, że kapsaicyna może mieć korzystny wpływ na ogólne objawy nosowe przez okres do 36 tygodni po leczeniu32. Ze względu na to, że wiele innych opcji leczenia nie działa dobrze w przypadku nieallergicznego nieżytu nosa, kapsaicyna może być rozsądną opcją do wypróbowania pod nadzorem lekarza32.
Leczenie chirurgiczne
W niektórych przypadkach, gdy leczenie farmakologiczne nie przynosi oczekiwanych rezultatów, może być konieczne leczenie chirurgiczne. Operacja jest zazwyczaj zalecana w przypadku współistniejących problemów, takich jak:
- Polipy nosa – wymagające usunięcia13
- Skrzywiona przegroda nosowa (deviated septum) – wymagająca korekcji13
- Przerost małżowin nosowych – wymagający redukcji34
Warto podkreślić, że sama operacja nie leczy nieallergicznego nieżytu nosa, ale może poprawić skuteczność stosowanych leków i zmniejszyć nasilenie objawów2310.
W niektórych przypadkach może być również rozważana neurektomia nerwu Widiusza (vidian neurectomy), która polega na przecięciu włókien przywspółczulnych unerwiających błonę śluzową nosa3534. Zabieg ten może być skuteczny w kontrolowaniu opornego na leczenie wodnistego wycieku z nosa35.
Leczenie w populacjach szczególnych
Leczenie u dzieci
Nieallergiczny nieżyt nosa jest rzadko spotykany u dzieci i jest słabo poznany36. Leczenie powinno być dostosowane do wieku dziecka i nasilenia objawów.
Niektóre leki, które mogą być stosowane u dzieci z nieallergicznym nieżytem nosa, to:
- Kortykosteroidy donosowe, takie jak mometazon (Nasonex), które są zatwierdzone przez FDA dla dzieci powyżej 2 roku życia37
- Kromoglikan sodowy (Intal), który może być stosowany w leczeniu objawów kichania i obrzęku śluzówki u dzieci powyżej 2 roku życia37
Leczenie w czasie ciąży
Kobiety w ciąży z objawami nieallergicznego nieżytu nosa mogą bezpiecznie stosować płukanie nosa roztworem soli fizjologicznej37. W przypadku konieczności zastosowania farmakoterapii, należy rozważyć potencjalne ryzyko i korzyści wynikające z użycia zatwierdzonych przez FDA donosowych leków przeciwcholinergicznych, przeciwhistaminowych i kortykosteroidów37.
Kompleksowe podejście do leczenia
Leczenie nieallergicznego nieżytu nosa powinno być dostosowane do indywidualnych potrzeb pacjenta i opierać się na dominujących objawach38. Zaleca się podejście stopniowe, rozpoczynając od nieinwazyjnych metod, takich jak unikanie czynników wyzwalających i płukanie nosa, a następnie, w razie potrzeby, wdrażając farmakoterapię i ewentualnie rozważając leczenie chirurgiczne w przypadkach opornych na leczenie3839.
Regularne wizyty kontrolne u lekarza są istotne w celu oceny skuteczności leczenia i ewentualnej modyfikacji terapii40. W niektórych przypadkach może być konieczne długoterminowe stosowanie leków, ponieważ objawy nieallergicznego nieżytu nosa mogą utrzymywać się przez całe życie21.
Warto również pamiętać, że nieleczony nieallergiczny nieżyt nosa może prowadzić do poważnych konsekwencji, takich jak zapalenie zatok, polipy nosa, infekcje zatok i przewlekłe infekcje ucha3. Dlatego też, wczesne rozpoznanie i odpowiednie leczenie są kluczowe dla zapewnienia dobrej jakości życia pacjentom z tym schorzeniem.
Porównanie skuteczności różnych metod leczenia
| Metoda leczenia | Skuteczność w leczeniu objawów | Czas do wystąpienia efektu | Czas trwania efektu | Potencjalne działania niepożądane |
|---|---|---|---|---|
| Kortykosteroidy donosowe | Wysoka dla większości objawów, w tym obrzęku śluzówki, uczucia zatkania nosa, spływania wydzieliny po tylnej ścianie gardła, kichania i świądu | 24-72 godzin, pełny efekt po kilku dniach lub tygodniach | Utrzymuje się przez czas stosowania | Suchość nosa lub gardła, krwawienia z nosa, bóle głowy |
| Donosowe leki przeciwhistaminowe | Dobra dla spływania wydzieliny po tylnej ścianie gardła, obrzęku śluzówki i kichania | Kilka minut | Krótkotrwały, wymagane regularne stosowanie | Zazwyczaj dobrze tolerowane |
| Ipratropium bromek | Wysoka dla wodnistego wycieku z nosa (rhinorrhea) | Szybki | Utrzymuje się przez czas stosowania | Krwawienia z nosa, suchość w nosie |
| Dekongestanty | Dobra dla obrzęku śluzówki i uczucia zatkania nosa | Szybki | Krótkotrwały, nie zalecane długotrwałe stosowanie | Podwyższone ciśnienie krwi, kołatanie serca, niepokój, efekt z odbicia przy dłuższym stosowaniu |
| Leczenie skojarzone (kortykosteroid + lek przeciwhistaminowy) | Wyższa niż monoterapia dla większości objawów | Szybki do średniego | Utrzymuje się przez czas stosowania | Kombinacja działań niepożądanych obu leków |
| Płukanie nosa roztworem soli fizjologicznej | Umiarkowana, najlepsza dla spływania wydzieliny po tylnej ścianie gardła | Natychmiastowy | Krótkotrwały, wymagane regularne stosowanie | Minimalne, możliwe podrażnienie przy nieprawidłowym stosowaniu |
| Krioterapia (ClariFix) | Wysoka dla wodnistego wycieku z nosa i uczucia zatkania nosa | 7-30 dni | Do roku lub dłużej | Minimalne, zabieg dobrze tolerowany |
| RhinAer | Wysoka dla większości objawów przewlekłego nieżytu nosa | Średni | Długotrwały | Minimalne, zabieg dobrze tolerowany |
| Kapsaicyna | Umiarkowana do wysokiej dla ogólnych objawów nosowych | Średni | Do 36 tygodni | Miejscowe podrażnienie |
| Leczenie chirurgiczne | Zależna od problemu, najlepsza dla obrzęku śluzówki związanego z wadami anatomicznymi | Po wygojeniu | Długotrwały | Ryzyko związane z zabiegiem chirurgicznym |
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Materiały źródłowe
- #1 Nonallergic rhinitis – Diagnosis & treatment – Mayo Clinichttps://www.mayoclinic.org/diseases-conditions/nonallergic-rhinitis/diagnosis-treatment/drc-20351235
Treatment of nonallergic rhinitis depends on how much it bothers you. Home treatment and staying away from triggers might be enough for mild cases. Medicines may ease worse symptoms. These include: […] Saline nose sprays. Saline is a mixture of salt and water. Saline nose spray helps moisturize the nose. It also helps thin mucus and soothes the tissue that lines the inside of the nose. […] Antihistamine nasal sprays. Antihistamines treat many health problems, including allergies. An antihistamine nose spray may ease the symptoms of nonallergic rhinitis too. Your provider may write you a prescription that lets you buy this type of spray at a pharmacy. […] Ipratropium nose spray. This prescription spray can ease a runny, drippy nose. Side effects can include nosebleeds and dryness inside the nose.
- #2 Vasomotor Rhinitis: Symptoms, Causes & Treatmenthttps://my.clevelandclinic.org/health/diseases/17950-nonallergic-rhinitis
Vasomotor rhinitis is inflammation of nasal tissues that results in sneezing, nasal congestion, runny nose or postnasal drip. […] There isnt a cure for nonallergic rhinitis. Most people manage symptoms with self-care measures, changes to their environment and medicine. […] If your condition results from exposure to triggers like perfumes, treatment may be as simple as avoiding the trigger. In those cases where avoiding the trigger is impossible, you can put measures in place to ease symptoms, try over-the-counter medications or get a prescription from a healthcare provider. […] Prescribed medications can decrease nasal inflammation and manage your symptoms. These medications may include: Decongestant nasal sprays to relieve nasal congestion. Antihistamine nasal sprays that reduce nasal inflammation. Corticosteroid nasal sprays (like fluticasone) to reduce nasal inflammation (first-line treatment for nasal congestion). Anticholinergic nasal sprays (like ipratropium bromide) to help with a runny nose. […] Surgery may be an option if the medications arent helping or if another condition is intensifying the problem, like a deviated septum or nasal polyps.
- #3 Vasomotor Rhinitis Program | Rochester Regional Healthhttps://www.rochesterregional.org/services/allergy-immunology-rheumatology/allergy/vasomotor-rhinitis-program
There is no cure for vasomotor rhinitis. With the help of your allergist, you can find ways to manage your symptoms and avoid environmental issues that may exacerbate them. […] Many people also find relief by rinsing their nasal passages with a salt water (saline) solution to clean out your nose and its nasal cavities. […] For some, prescription medications can manage symptoms and decrease nasal inflammation. Medications prescribed by your allergist may include: […] Anticholinergic nasal sprays – minimize the amount of mucus produced in your nose […] Antihistamine nasal sprays – work to reduce inflammation in your nose […] Corticosteroid nasal sprays – work to reduce nasal inflammation […] Decongestant nasal sprays – relieve nasal congestion. […] If left untreated, non-allergic rhinitis may result in a constantly running nose or persistently blocked nasal passages. These can lead to ear infections, nasal polyps, sinusitis, sinus infections, difficulty concentrating and sleeping, and irritability.
- #4 Nonallergic Rhinitis – Vasomotor Definedhttps://www.aaaai.org/tools-for-the-public/allergy,-asthma-immunology-glossary/nonallergic-rhinitis-vasomotor-defined
Nonallergic rhinitis cannot be cured, but many people find relief by avoiding triggers, using a saline rinse solution or by taking over-the-counter or prescription medications.
- #5 Patient education: Nonallergic rhinitis (runny or stuffy nose) (Beyond the Basics) – UpToDatehttps://www.uptodate.com/contents/nonallergic-rhinitis-runny-or-stuffy-nose-beyond-the-basics
Patient education: Nonallergic rhinitis (runny or stuffy nose) (Beyond the Basics) […] NONALLERGIC RHINITIS TREATMENT […] Treatment of nonallergic rhinitis includes trigger avoidance, medications, and/or nasal rinsing or irrigation. […] Trigger avoidance â Exposure to tobacco smoke can be reduced if household members stop smoking or smoke only outside of the home. It is also important to avoid smoke exposure in the workplace. […] Nasal rinsing and irrigation â Simply rinsing the nose with a salt water (saline) solution one or more times per day is helpful for many patients with nonallergic rhinitis, as well as for other rhinitis conditions. […] Medications that may help symptoms â Daily use of a nasal glucocorticoid (steroid) and/or an antihistamine nasal spray can be helpful for people with nonallergic rhinitis. These medications may be used alone or in combination.
- #6 Management of Rhinitis: Allergic and Non-Allergichttps://pmc.ncbi.nlm.nih.gov/articles/PMC3121056/
Avoidance of environmental triggers such as strong odors (perfumes, soaps, paint, etc.) and air pollutants (smoke fumes, tobacco smoke) that are respiratory irritants is recommended in those who find these worsen their rhinitis symptoms. […] […] The anticholinergic ipratropium bromide is available in a nasal form and blocks the parasympathetic signaling that leads to watery rhinorrhea, and it has been shown effective in controlling this particular symptom. There are little to no side effects. Guidelines state it does not decrease sneezing or nasal obstruction, but one study in children showed improvement in rhinorrhea, congestion, and sneezing although to a lesser degree than intranasal steroids.
- #6 Management of Rhinitis: Allergic and Non-Allergichttps://pmc.ncbi.nlm.nih.gov/articles/PMC3121056/
The only topical anticholinergic medication approved in the United States for topical application is ipratropium bromide. Ipratropium bromide (0.03%) nasal spray is recommended when rhinorrhea is the predominant or only symptom, as in the case of gustatory rhinitis. From the updated rhinitis practice parameters, its use in combination with an intranasal corticosteroid is more effective than either drug alone for the treatment of rhinorrhea. This is not only effective, but safe as well since there is not an increased incidence of adverse events. […] […] Currently there are no specific studies looking at the effectiveness of oral decongestants in the treatment of NAR. Thus, they should be considered adjunctive therapy, which is used on an as needed basis for nasal congestion that is not responsive to intranasal corticosteroids, topical antihistamines, or a combination of both. […]
- #7 Nonallergic (Vasomotor) Rhinitis: Symptoms, Causes and Treatmenthttps://www.webmd.com/allergies/nonallergic-rhinitis
Nonallergic rhinitis can’t be cured, but its symptoms can be controlled by: […] – Avoiding rhinitis triggers […] – Using home remedies such as nasal irrigation […] – Taking over-the-counter and prescription medications […] – Using a bioelectronic sinus device […] Allergy shots (immunotherapy) are not used to treat nonallergic rhinitis. […] If you have nonallergic rhinitis, it’s important to stop smoking. Also, don’t allow smoking in your home. […] Other ways to reduce exposure to triggers include: […] – Avoid wood-burning stoves and fireplaces if they cause symptoms. […] – Avoid cleaning products, household sprays, perfumes, and scented products if they cause symptoms. […] – Ask family, friends, and coworkers not to use scented products that cause symptoms.
- #8 Nonallergic (Vasomotor) Rhinitis: Symptoms, Causes and Treatmenthttps://www.webmd.com/allergies/nonallergic-rhinitis
– Avoid any chemical or material that tends to make you sneeze or have a runny nose. […] Talk to your doctor about the medications you take. If your nonallergic rhinitis is triggered by a medicine you need, your doctor may suggest a substitute. […] Medications for nonallergic rhinitis include: […] Nasal antihistamines […] Prescription products such as azelastine (Astelin) and olopatadine (Patanase) can relieve symptoms of postnasal drip, congestion, and sneezing within minutes. Theyâre most effective when used on a regular basis. […] Nasal glucocorticoids […] Daily use of medications such as budesonide (Rhinocort Allergy), fluticasone (Flonase), or triamcinolone (Nasacort Allergy 24HR) may help relieve symptoms. These nasal sprays are available over the counter. It may take days or weeks to notice the full effects. Sometimes, people benefit from using a combination of nasal antihistamines and nasal glucocorticoids.
- #9 Chronic Nonallergic Rhinitis | AAFPhttps://www.aafp.org/pubs/afp/issues/2018/0801/p171.html
Chronic nonallergic rhinitis encompasses a group of rhinitis subtypes without allergic or infectious etiologies. Treatment is symptom-driven and similar to that of allergic rhinitis. Patients should avoid known triggers when possible. First-line therapies include intranasal corticosteroids, intranasal antihistamines, and intranasal ipratropium. […] Combination therapy with an intranasal corticosteroid and intranasal antihistamine is better than either treatment alone. […] Intranasal corticosteroids are first-line therapy for nonallergic rhinitis. […] Subgroups of patients with nonallergic rhinitis may not respond to intranasal corticosteroids, such as those with symptoms triggered predominantly by weather and temperature changes. […] Intranasal antihistamines are effective for nonallergic rhinitis, likely because of their actions as anti-inflammatory and neuroinflammatory blockers.
- #10 Allergic & Nonallergic Rhinitis NYC | Mount Sinai – New Yorkhttps://www.mountsinai.org/care/ent/services/nasal-sinus-allergy/conditions/rhinitis
Avoidance of triggers: the first line in the treatment armamentarium and often overlooked! This can be an efficient and effective method to reduce symptoms. […] Nasal corticosteroids: this is the gold standard for non-allergic and allergic rhinitis; they are effective in treating most rhinitis cases, reducing inflammation and nasal symptoms (congestion, itching, nasal drip, sneezing). […] There is no surgical treatment specifically for allergic or nonallergic rhinitis. Surgical treatment revolves around ameliorating symptoms, such as nasal drip and nasal congestion/obstruction. Addressing anatomical abnormalities (deviated septum, inferior turbinate enlargement, and nasal valve collapse) can help with obstruction. […] Allergic and nonallergic rhinitis can be overwhelming, as symptoms are often chronic and can cause distress in many peopleâs lives. The treatment of these symptoms can feel daunting, but we here at Mount Sinai can help you navigate the treatment steps and help you select the treatment that both improves your quality of life and enjoy living again.
- #11 Management of Rhinitis: Allergic and Non-Allergichttps://pmc.ncbi.nlm.nih.gov/articles/PMC3121056/
Nonallergic rhinitis (NAR) is generally described as chronic nasal symptoms, such as obstruction and rhinorrhea that occur in relation to nonallergic, noninfectious triggers such as change in the weather, exposure to caustic odors or cigarette smoke, barometric pressure differences, etc. There is a lack of concomitant allergic disease, determined by negative skin prick test for relevant allergens and/or negative allergen-specific antibody tests. The term vasomotor is often used which suggests involvement of neural, glandular, and vascular pathways; however, this term is misleading because it implies a true understanding of the underlying pathophysiology of the disease when this has not been definitively established. […] […] Intranasal corticosteroids have been found to be effective in nonallergic rhinitis, especially in vasomotor rhinitis and NARES. Fluticasone propionate and beclomethasone are the only topical corticosteroids approved by the FDA in the US for the treatment of NAR. Clinically, there does not appear to be a difference between the intranasal steroids available at this time. Most are dosed twice daily and patients should be informed that it may take 24 to 72 hours before symptoms start to improve though the onset of action is said to be from 3-12 hours. […]
- #12 Nonallergic rhinitis // Middlesex Healthhttps://middlesexhealth.org/learning-center/diseases-and-conditions/nonallergic-rhinitis
Ipratropium nose spray. This prescription spray can ease a runny, drippy nose. Side effects can include nosebleeds and dryness inside the nose. […] Decongestants. These medicines help narrow the blood vessels in the nose and lessen congestion. Side effects can include high blood pressure, heart pounding and feeling restless. Decongestants can be bought off store shelves or with a prescription. Examples include drugs with pseudoephedrine (Sudafed 24 Hour) and phenylephrine. […] Steroids. These medicines help prevent and treat swelling linked with some types of nonallergic rhinitis. Side effects can include a dry nose or throat, nosebleeds, and headaches. Your provider may suggest a steroid nose spray if decongestants or antihistamines don’t control your symptoms. Steroid sprays that you can buy off the shelf include a fluticasone (Flonase Allergy Relief) and triamcinolone (Nasacort Allergy 24 Hour). Stronger steroid sprays also can be prescribed.
- #12 Nonallergic rhinitis // Middlesex Healthhttps://middlesexhealth.org/learning-center/diseases-and-conditions/nonallergic-rhinitis
Treatment of nonallergic rhinitis depends on how much it bothers you. Home treatment and staying away from triggers might be enough for mild cases. Medicines may ease worse symptoms. These include: […] Saline nose sprays. Saline is a mixture of salt and water. Saline nose spray helps moisturize the nose. It also helps thin mucus and soothes the tissue that lines the inside of the nose. You can buy saline nose spray off the shelf at stores. But a home remedy known as nose irrigation might work even better. It involves using a large amount of saline or a saltwater mixture to help clean out irritants and mucus. […] Antihistamine nasal sprays. Antihistamines treat many health problems, including allergies. An antihistamine nose spray may ease the symptoms of nonallergic rhinitis too. Your provider may write you a prescription that lets you buy this type of spray at a pharmacy. These sprays include azelastine (Astepro, Astepro Allergy) or olopatadine hydrochloride (Patanase). Antihistamines taken by mouth often don’t work as well for nonallergic rhinitis as they do for allergic rhinitis. These antihistamines include diphenhydramine (Benadryl), cetirizine (Zyrtec Allergy), fexofenadine (Allegra Allergy) and loratadine (Alavert, Claritin).
- #13 Nonallergic rhinitis – Diagnosis & treatment – Mayo Clinichttps://www.mayoclinic.org/diseases-conditions/nonallergic-rhinitis/diagnosis-treatment/drc-20351235
Decongestants. These medicines help narrow the blood vessels in the nose and lessen congestion. Side effects can include high blood pressure, heart pounding and feeling restless. […] Steroids. These medicines help prevent and treat swelling linked with some types of nonallergic rhinitis. Side effects can include a dry nose or throat, nosebleeds, and headaches. Your provider may suggest a steroid nose spray if decongestants or antihistamines don’t control your symptoms. […] Your health care provider may suggest surgery to treat other problems that can happen with nonallergic rhinitis. For example, growths in the nose called polyps may need to be removed. Surgery also can fix a problem where the thin wall between the passages in the nose is off-center or crooked. This is called a deviated septum.
- #14 Treatment of nonallergic perennial rhinitis – PubMedhttps://pubmed.ncbi.nlm.nih.gov/14984552/
Nonallergic perennial rhinitis (also commonly referred to as vasomotor rhinitis) is a chronic non-IgE-mediated condition that is characterized by symptoms which are similar to those seen in allergic rhinitis, but which persist for over nine months each year. […] Although treatment of vasomotor rhinitis involves the use of either intranasal corticosteroids or antihistamines, the corticosteroids are generally not effective in treatment of all the symptoms of vasomotor rhinitis and have generally been shown to be effective in patients with eosinophilia. […] With the exception of azelastine, the only topical antihistamine to be approved by the FDA for the treatment of nonallergic rhinitis, the antihistamines have also produced inconsistent results. […] While clinical studies of azelastine have demonstrated that this drug is highly efficacious in the treatment of all the symptoms of vasomotor rhinitis, mechanistic studies have demonstrated that azelastine has potent anti-inflammatory effects (in particular attenuation of the expression and synthesis of pro-inflammatory cytokines, leukotrienes, and cell adhesion molecules), which are likely to contribute to its clinical efficacy.
- #15 Pharmacotherapy for Nonallergic Rhinitis: Overview, Distinguishing Types of Nonallergic Rhinitis, Pharmacotherapyhttps://emedicine.medscape.com/article/874171-overview
Nasal corticosteroids follow the same pathway of reducing inflammation as that of medications taken systemically, but their anti-inflammatory activity is localized to the upper airway. […] Nasal corticosteroids are also useful in patients with NARES, as evidence suggests that they inhibit inactivation of eosinophils and the resultant cascade leading to inflammation. […] A study by Kirtsreesakul et al, however, found that although patients with nonallergic rhinitis experienced improvement from nasal steroid therapy, it was to a lesser extent than in patients with allergic rhinitis. […] Antihistamines are useful in relieving rhinorrhea, sneezing, and nasal pruritus. […] Some nasal antihistamines, such as azelastine, have a labeled indication for the treatment of vasomotor rhinitis. […] A newer nasal antihistamine, olopatadine, which is approved for allergic rhinitis, was found to have similar efficacy and safety when compared with azelastine in a multicenter, randomized, double-blind clinical trial.
- #16 Vasomotor Rhinitis | AAFPhttps://www.aafp.org/pubs/afp/issues/2005/0915/p1057.html
With nasal congestion and obstruction only, topical corticosteroids would be a wise starting point for therapy. […] If the patient presents with the full range of symptoms including rhinorrhea with sneezing, postnasal drip, and congestion, a topical antihistamine may be initiated. […] Traditional oral antihistamines have no established beneficial effect in patients with vasomotor rhinitis and may be associated with sedation. […] Newer, less-sedating antihistamines also have no proven effectiveness for vasomotor rhinitis, and their administration delays proper treatment while incurring significant cost and burden to the health care system. […] The empiric use of the topical decongestant ephedrine on a chronic basis has resulted in tolerance and development of rhinitis medicamentosa.
- #17 Chronic Nonallergic Rhinitis | AAFPhttps://www.aafp.org/pubs/afp/issues/2018/0801/p171.html
Although there is more evidence for using intranasal corticosteroids combined with intranasal antihistamines to treat allergic rhinitis, this combination is also beneficial in patients with nonallergic rhinitis whose symptoms are not adequately controlled with either therapy alone. […] Intranasal ipratropium has been proven effective in decreasing rhinorrhea and is a reasonable monotherapy for patients who have rhinorrhea as a predominant symptom. […] Decongestants effectively manage congestion regardless of etiology. […] Nasal irrigation with saline or hypertonic saline may be helpful in the treatment of nonallergic rhinitis. […] Further investigation is needed for irrigation and intranasal capsaicin in the treatment of nonallergic rhinitis.
- #18 Nonallergic (Vasomotor) Rhinitis: Symptoms, Causes and Treatmenthttps://www.webmd.com/allergies/nonallergic-rhinitis
Nasal ipratropium […] Ipratropium bromide (Atrovent) is considered the best treatment for the watery nasal discharge that comes from eating and drinking certain foods and beverages. […] Decongestants […] Oral decongestant medications, such as pseudoephedrine, may help relieve congestion. But these are not generally recommended unless nasal antihistamines and nasal glucocorticoids donât help. Decongestant nasal sprays containing oxymetazoline (Afrin) and phenylephrine (Neo-synephrine) should not be used for more than two to three days at a time. Doing so can cause overuse (rebound) congestion. […] Nasal irrigation […] Many people with nonallergic rhinitis benefit from performing nasal irrigation. This refers to rinsing of the nostrils with a saltwater (saline) solution one or more times a day. Over-the-counter products for doing this include bulb syringes, neti pots, and bottle sprayers. During each irrigation, rinse each nostril with at least 200 milliliters (about 3/4 cup) of commercially or home-prepared solution.
- #19 Gustatory Rhinitis: Why Your Nose Runs When You Eathttps://www.verywellhealth.com/gustatory-rhinitis-82824
If your runny nose is related to an allergy, you might be able to manage your symptoms with OTC antihistamines, such as: […] If you have nonallergic rhinitis, antihistamines, and other allergy treatments will not help with your symptoms. You might get some relief from other products, though. […] For example, a product like Nasal Atrovent (ipratropium bromide nasal spray) may help prevent and treat your symptoms. One or two sprays in each nostril about an hour before eating spicy foods should do the trick. […] Nasal rinses can sometimes be helpful for any kind of rhinitis since they clear mucus out of your nose. You can get these products OTC or make one yourself at home. If you choose to make one at home, be sure to use sterile procedures to avoid a life-threatening infection. […] It may take a few weeks to find the treatment that works best, and you might need to use a combination of treatments.
- #20 Nonallergic Rhinitis – Ear, Nose, and Throat Disorders – Merck Manual Professional Editionhttps://www.merckmanuals.com/professional/ear-nose-and-throat-disorders/nose-and-paranasal-sinus-disorders/nonallergic-rhinitis
Treatment of vasomotor rhinitis is by trial and error and is not always satisfactory. […] Topical corticosteroids (eg, mometasone 2 sprays twice a day) and nasal antihistamines can be of some benefit. […] Systemic sympathomimetic amines (eg, for adults, pseudoephedrine 30 mg orally every 4 to 6 hours as needed) relieve symptoms but are not recommended for long-term use because they thicken the mucus and may cause tachycardia and nervousness. […] Rebound congestion can result after 3 days of continuous use; chronic use and dependence is known as rhinitis medicamentosa.
- #21 Patient education: Nonallergic rhinitis (runny or stuffy nose) (Beyond the Basics) – UpToDatehttps://www.uptodate.com/contents/nonallergic-rhinitis-runny-or-stuffy-nose-beyond-the-basics
Nasal antihistamines â A prescription nasal antihistamine spray, such as azelastine (eg, Astelin, Astepro) or Patanase, can relieve symptoms of postnasal drip, congestion, and sneezing. […] Nasal glucocorticoids (steroids) â Nasal glucocorticoids (steroids) have been shown to be effective for symptoms of nonallergic rhinitis. […] Nasal ipratropium (Atrovent nasal spray) â A runny nose with profuse, watery discharge from the nose (rhinorrhea) can be treated with ipratropium (0.03 percent or 0.06 percent) nasal spray. […] Combination nasal antihistamine and nasal glucocorticoid (steroid) â There is a nasal spray (Dymista) that contains both azelastine and fluticasone. […] Decongestants â Oral decongestant medications (like pseudoephedrine or phenylephrine) help to relieve symptoms of congestion (stuffiness) in some people. However, this treatment is not usually recommended unless nasal antihistamines and nasal glucocorticoids (steroids) do not improve symptoms. […] How long will I need treatment? â The dose or frequency of medications can be reduced in some patients over time. However, in most patients, symptoms are lifelong, and some medication is usually needed on a daily and long-term basis.
- #22 What Is Gustatory Rhinitis? What Causes It and How It’s Treatedhttps://www.webmd.com/allergies/what-to-know-gustatory-rhinitis
Combination medicine. Dymista is a prescription medicine that contains two types of medicine. It has both an antihistamine and glucocorticoid. […] Decongestants. Oral decongestants are not usually used unless nasal antihistamines and nasal glucocorticoids haven’t worked for you. Oral decongestants can help with stuffiness but they have side effects such as increased blood pressure, nervousness, and difficulty sleeping.
- #23 Nonallergic (Vasomotor) Rhinitis: Symptoms, Causes and Treatmenthttps://www.webmd.com/allergies/nonallergic-rhinitis
It’s important to note that, according to the CDC, if you are irrigating, flushing, or rinsing your sinuses, use distilled, sterile, or previously boiled water to make the irrigation solution. Its also important to rinse the irrigation device after each use and leave it open to air dry. When performed once or twice a day, nasal irrigation may especially help treat postnasal drip. It’s also a helpful technique to clear the sinuses before using medicated nasal sprays. […] In some cases, surgery to remove nasal polyps or correct a deviated septum can improve the way medications for nonallergic rhinitis work. Surgery is only considered as a treatment by itself when other treatments have failed to reduce symptoms.
- #24 The Difference Between Allergic and Nonallergic Rhinitis | South Valley Ear Nose & Throat | Bloghttps://southvalleyent.com/the-difference-between-allergic-and-nonallergic-rhinitis/
Nonallergic rhinitis can affect children and adults but is more common in those aged 20 and over. Common triggers include but are not limited to: […] Treatment for nonallergic rhinitis will vary depending on the severity of the symptoms. Worsening or chronic symptoms may require saline or antihistamine nasal sprays, decongestants or steroids. Mild cases may be able to be managed through home remedies, including but not limited to: […] Use a humidifier. A humidifier can help add a little bit of moisture to Utahs dry air. Adding a little bit of moisture to the environment around you can reduce dryness and irritation caused by nonallergic rhinitis.
- #25 Rhinitis – La Crosse, Wisconsin – Mayo Clinic Health Systemhttps://www.mayoclinichealthsystem.org/locations/la-crosse/services-and-treatments/otorhinolaryngology/nose-conditions-and-treatment/rhinitis
Nonallergic rhinitis occurs when no obvious irritant or allergen is present and can seem to start with no apparent cause. […] Treatment of nonallergic rhinitis depends on how much it bothers you. For mild cases, home treatment and avoiding triggers may be enough. For more-bothersome symptoms, certain medications may provide relief including nasal sprays and decongestants. […] Cryotherapy, or cold therapy, is an innovative, minimally invasive treatment for rhinitis. Cryotherapy uses an endoscope and cryotherapy device to freeze nerves in your nasal passages. When the cold temperature hits the nerves, the nerve signals are interrupted and no longer tell the nose to swell, drip and run. The interruption of the nerve signals provides long-lasting relief from runny or stuffy nasal symptoms. Cryotherapy can provide patients with symptom relief for up to a year or longer.
- #26 Best Vasomotor Rhinitis Treatment in Los Angeleshttps://www.drdaneshrad.com/ent-conditions/nasal-conditions/vasomotor-rhinitis
Its estimated that up to one out of every 10 Americans suffers from intermittent episodes of sneezing or a congested, runny nose for no apparent cause. […] Dr. Daneshrad, widely considered the best ENT in Los Angeles, diagnoses and treats constantly running noses and the irritating symptoms of vasomotor rhinitis at our two locations in Santa Monica and Torrance. […] While mild cases may benefit from home remedies like nasal irrigation or over-the-counter sprays, more severe symptoms often require a lasting solution. ClariFix is a breakthrough cryotherapy treatment that targets the root cause of vasomotor rhinitis overactive nerves. […] ClariFix is a minimally invasive, more effective, long-term solution with an in-office procedure that uses cryotherapy to calm the overactive nasal nerves responsible for symptoms.
- #27 Chronic Rhinitis | ENT | Florida Sinus & Snoring Specialistshttps://www.southfloridasinusandallergy.com/can-find-relief-chronic-rhinitis/
Breakthroughs in medical research and technology have led to some exciting new treatment options specifically ClariFix cooling and oral mucosal immunotherapy. […] ClariFix Cooling is whats known as cryotherapy or localized freezing. It works by inserting a small Clarifix balloon into the back of your nasal cavity, right next to a cluster of nerves that are overreacting and causing your chronic allergic rhinitis. The balloon is then cooled and freezes both the nerves and surrounding tissue. The entire procedure is performed in-office under local anesthesia, which makes it comfortable and minimizes any pain. […] The best part about ClariFix Cooling is that it takes as little as five minutes to perform and provides long-lasting relief! […] Oral mucosal immunotherapy (often shortened to OMIT) is another innovative chronic rhinitis treatment that uses specially formulated toothpaste. Its similar to subcutaneous immunotherapy (SCIT) in that it uses tiny amounts of allergens to help your body build immunity and reduce chronic allergic rhinitis symptoms. OMIT does this without the need for injections, though, and is much more convenient.
- #28 Your Runny Nose Could Be Non-Allergic Rhinitis | North Atlanta ENT & Allergyhttps://naenta.com/your-runny-nose-could-be-non-allergic-rhinitis/
ClariFix Cryotherapy goes to the root of the problem the inflamed nasal tissue and the underlying nerves, for long-term chronic rhinitis symptom relief. […] In a clinical study, four out of five people reported long-lasting improvement with the ClariFix device, including a reduction in a runny nose and congestion. […] ClariFix is safe. In a clinical study, the ClariFix device was found to be well-tolerated with no device or procedure-related serious adverse events. […] Most patients begin to see improvement between 7 days and 30 days post-treatment. Chronic rhinitis symptoms (including runny, stuffy nose) improved 56% at 90 days and IMPROVEMENT WAS MAINTAINED AT ONE YEAR.
- #29 RhinAer® | Chronic Runny Nose | Nonallergic Rhinitis Treatment Austin, TXhttps://www.austinent.com/services/nose/rhinaer-for-chronic-runny-nose/
RhinAer for Chronic Runny Nose […] Nonsurgical Treatment for Nonallergic Rhinitis […] For the 30 million Americans who suffer from nonallergic rhinitis â which prompts a runny nose not caused by allergies â this condition can significantly disturb daily life, including your sleep quality. […] All that is about to change. The RhinAer procedure was approved by the FDA in 2020 as a safe and effective non-surgical solution for patients with a chronic runny nose. […] Austin ENT Clinic is proud to offer the minimally invasive RhinAer procedure. […] RhinAer uses low-temperature radiofrequency energy to disrupt the nerve fibers associated with triggering a runny nose. […] The RhinAer procedure is preferred over a similar relatively new procedure (ClariFix® Cryotherapy), which uses liquid nitrogen to freeze and destroy the nerve tissue.
- #30 CHRONIC RHINITIS REQUIRES COMPREHENSIVE TREATMENThttps://rhinaer.com/hcp/
RhinAer has been demonstrated to provide lasting relief of chronic rhinitis. […] Many in-office treatments for rhinitis are not comprehensive, while surgical options like septoplasty, turbinate reduction, or other ablative technologies yield mixed patient responses and may not address all symptoms. […] RhinAer is the only non-invasive, in-office solution that targets the multiple sources of chronic rhinitis, offering lasting relief from runny nose, post-nasal drip, and congestion for both allergic and non-allergic patients. […] Treatment of the PNN using RhinAer has been shown to be an effective, patient-friendly option to treat both chronic allergic and non-allergic rhinitis. Its exciting that otolaryngologists have a safe, non-invasive treatment option that can be performed in the clinic under local anesthesia and that provides long-term benefits for our patients.
- #31 RhinAer® | Chronic Runny Nose | Nonallergic Rhinitis Treatment Austin, TXhttps://www.austinent.com/services/nose/rhinaer-for-chronic-runny-nose/
You donât need to suffer with a chronic runny nose a moment longer! Find out if you may benefit from the RhinAer procedure. […] Additional benefits of the RhinAer procedure include improved sleep, reduced risk of sinus infections, less daytime sleepiness, improved concentration, and being better able to handle stress.
- #32 Capsaicin for non-allergic rhinitis | Cochranehttps://www.cochrane.org/CD010591/ENT_capsaicin-non-allergic-rhinitis
Capsaicin may be an option in the treatment of idiopathic non-allergic rhinitis. It is given in the form of brief treatments, usually during the same day. It appears to have beneficial effects on overall nasal symptoms up to 36 weeks after treatment, based on a few, small studies (low-quality evidence). […] Given that many other options do not work well in non-allergic rhinitis, capsaicin is a reasonable option to try under physician supervision. […] Capsaicin, the active component of chili peppers, delivered intranasally, is considered a treatment option for non-allergic rhinitis.
- #33 Frontiers | Multifaceted Treatment Options for Nonallergic Rhinitishttps://www.frontiersin.org/research-topics/68159/multifaceted-treatment-options-for-nonallergic-rhinitisundefined
Complementary to these pharmacological agents is Saline Irrigation, which aids in clearing nasal passages of irritants and mucus, thus mitigating nasal congestion. An adjunctive treatment option, Decongestants, offers immediate relief from nasal stuffiness, though they must be used judiciously to avoid the risk of rebound congestion. Capsaicin Sprays, though unconventional, have demonstrated their worth by desensitizing nasal nerves and decreasing congestion and runny nose symptoms with regular use. […] Further from the mainstream, Oral Leukotriene Antagonists like montelukast have shown promise, particularly for those NAR patients who also suffer from asthma, hinting at overlapping therapeutic pathways that could benefit multiple conditions. Emerging alternative therapies such as acupuncture and homeopathy are under investigation with initial studies pushing for more rigorous research to validate their effectiveness fully. […] Given the heterogeneity of Nonallergic Rhinitis and its impact on quality of life, there is a continuous need for tailored, multi-modal treatment strategies that cater not only to symptom relief but also to the nuanced needs of individual patients.
- #34 Nonallergic rhinitis – Knowledge @ AMBOSShttps://www.amboss.com/us/knowledge/nonallergic-rhinitis/
Atrophic rhinitis is managed differently from other types of NAR. […] Conservative management options to reduce nasal crusting include: Nasal saline irrigation, Glycerin drops, Emollients, Antibiotics targeting specific pathogens, Nasal estradiol. […] Surgical options to decrease the volume of the nasal cavity: e.g., modified Young procedure, prostheses. […] There is no standard treatment algorithm for the management of NAR. […] Avoid triggers when possible; see Types of NAR. […] Start monotherapy with either of the following: Intranasal antihistamines (INAH): azelastine (off-label except for VMR), Intranasal corticosteroids (INCS): fluticasone or beclomethasone (off-label except for VMR). […] Consider adding the following: Intranasal saline as needed for symptom control [1]. […] Consider alternative monotherapy (preferred). […] Add or switch to a symptom-specific agent. […] Consider combination intranasal therapy of INAH + INCS; see First-line treatment for dosages. […] Refer to ENT for oral pharmacotherapy options and/or surgery (e.g., vidian neurectomy for VMR, turbinectomy).
- #34 Nonallergic rhinitis – Knowledge @ AMBOSShttps://www.amboss.com/us/knowledge/nonallergic-rhinitis/
Nonallergic rhinitis (NAR) is an acute or chronic rhinitis that is not immune mediated. […] Management includes avoidance of triggers and topical pharmacological treatment with intranasal antihistamines (INAH) and/or intranasal corticosteroids (INCS). […] Additional therapies (e.g., intranasal ipratropium, intranasal decongestants) are considered for certain types of NAR. […] Refractory or severe symptoms require specialist referral for advanced treatments (e.g., oral medications, surgery). […] Diagnosis is clinical; see Diagnosis of NAR. […] Initial treatment of VMR [1] […] Start monotherapy with INAH or INCS. […] Persistent symptoms: Add or switch to intranasal ipratropium to control anterior rhinorrhea. […] Severe or refractory symptoms: Endoscopic vidian neurectomy may be considered.
- #35 Nonallergic rhinitis – Wikipediahttps://en.wikipedia.org/wiki/Nonallergic_rhinitis
However, intranasal corticosteroids probably increase risk of nosebleeds. […] Astelin (azelastine) „is indicated for symptomatic treatment of vasomotor rhinitis including rhinorrhea, nasal congestion, and post nasal drip in adults and children 12 years of age and older.” […] Reduction of hypertrophied turbinates, correction of nasal septum deviation, removal of polyps, sectioning of the parasympathetic secretomotor fiber to nose (vidian neurectomy) for controlling refractory excessive rhinorrhea.
- #36 Pharmacotherapy for Nonallergic Rhinitis: Overview, Distinguishing Types of Nonallergic Rhinitis, Pharmacotherapyhttps://emedicine.medscape.com/article/874171-overview
Nasally applied sympathomimetics are imidazoline derivatives that cause local vasoconstriction through alpha 2-adrenergic agonistic properties, ultimately reducing nasal edema and obstruction. […] In June 2019, dupilumab became the first drug approved by the US Food and Drug Administration for the treatment of chronic rhinosinusitis with nasal polyps (CRSwNP) that has not otherwise been sufficiently controlled. […] Capsaicin use has been targeted to patients presenting with congestion, rhinorrhea, sneezing, or a combination of these symptoms. […] Patients who are pregnant and who present with symptoms of rhinitis are not limited to the specific diagnosis of hormonal rhinitis. […] Nonallergic rhinitis of all types is rare in children, and is poorly understood. […] Second-generation oral antihistamines may be used to control symptoms of rhinitis. […] Patients with renal insufficiency, hepatic insufficiency, or both are prone to augmentation of adverse events, resulting from a reduced clearance through renal and/or hepatic pathways. […] Surgical therapy should be considered a possible adjuvant to continued medical therapy.
- #37 Vasomotor Rhinitis | AAFPhttps://www.aafp.org/pubs/afp/issues/2005/0915/p1057.html
Certain nasal corticosteroids, such as mometasone furoate (Nasonex), are approved by the U.S. Food and Drug Administration (FDA) for children older than two years and improve the symptoms of congestion and nasal obstruction. […] Cromolyn sodium (Intal) can be used to manage symptoms of sneezing and congestion in children older than two years. […] Topical antihistamines, topical corticosteroids, and topical anticholinergics are treatments permitted by the U.S. Olympic Committee and the International Olympic Committee. […] Vasomotor rhinitis in pregnancy responds well to intranasal saline instillation. […] Potential risks versus benefits should be considered in the use of FDA-approved topical anticholinergics, topical antihistamines, and topical corticosteroids. […] All three types respond well to ipratropium nasal spray.
- #38 Vasomotor Rhinitis | AAFPhttps://www.aafp.org/pubs/afp/issues/2005/0915/p1057.html
Topical anticholinergics should be used for rhinorrhea caused by vasomotor rhinitis. […] Azelastine (Astelin) may be used for vasomotor rhinitis associated with rhinorrhea, sneezing, postnasal drip, and nasal congestion. […] Topical corticosteroids may be used for vasomotor rhinitis associated with nasal obstruction and congestion. […] Cromolyn sodium (Intal) may be used for vasomotor rhinitis associated with sneezing and congestion in patients older than two years. […] Once a working diagnosis of vasomotor rhinitis has been made, the patient can be empowered to avoid known environmental triggers as much as possible. […] A stepwise pharmacologic approach may then be employed, choosing the initial intervention based on the patients predominant symptoms. […] If the presenting symptom is solely rhinorrhea, a topical anticholinergic is the logical first step.
- #39 Vasomotor Rhinitis | AAFPhttps://www.aafp.org/pubs/afp/issues/2005/0915/p1057.html
Although no single agent is uniformly effective in controlling the many and varied symptoms of vasomotor rhinitis, available evidence supports a stepwise application of several agents after a careful history and physical examination. […] Additional therapies, for which AHRQ felt there was no strong evidence base, may be tried if the approved approaches fail.
- #40 Non-Allergic Rhinitis: Symptoms, Causes, & Treatmenthttps://www.allervie.com/condition/non-allergic-rhinitis/
Home-based saline nasal irrigation is another beneficial practice, offering a gentle means to cleanse and soothe inflamed nasal passages. […] Regular medical checkups for non-allergic rhinitis serve as proactive benchmarks in managing the condition effectively. […] Avoiding known triggers is essential for individuals with non-allergic rhinitis, as it helps prevent the onset of symptoms and minimizes nasal inflammation. […] Individuals with non-allergic rhinitis often find that regularly rinsing their nasal passages with saline solution can offer substantial relief.