Choroba koronawirusowa 2019 (covid-19)
Objawy
COVID-19, wywoływane przez SARS-CoV-2, manifestuje się głównie infekcją dróg oddechowych, z objawami od łagodnych (81% przypadków) do krytycznych (5%). Typowe symptomy obejmują gorączkę (78%), zmęczenie (68,3%), zaburzenia smaku i węchu (64,4%), kaszel (60,4%) oraz duszność (41,1%). Okres inkubacji wynosi 2-14 dni, z medianą 5-6 dni, skracając się do 2-4 dni dla wariantu Omikron. Progresja choroby może prowadzić do ARDS, niewydolności oddechowej i wstrząsu septycznego, z medianą wystąpienia duszności w 5-8 dni, ARDS w 8-12 dni oraz hospitalizacji na OIT w 10-12 dni. Klasyfikacja ciężkości według NIH obejmuje: bezobjawowy, łagodny, umiarkowany (SpO₂ ≥94%), ciężki (SpO₂ <94%, PaO₂/FiO₂ <300, nacieki >50%) oraz krytyczny przebieg. Czynniki ryzyka ciężkiego przebiegu to wiek powyżej 60-70 lat, choroby współistniejące (np. nadciśnienie, cukrzyca, otyłość), brak szczepienia oraz płeć męska. Powikłania obejmują zapalenie płuc, ARDS, uszkodzenia serca, zakrzepy, wstrząs septyczny i niewydolność wielonarządową. Long COVID dotyka 5-50% pacjentów, z objawami utrzymującymi się powyżej 12 tygodni, w tym zmęczeniem, dusznością, mgłą mózgową i bólami mięśniowo-stawowymi, wpływając na jakość życia i funkcjonowanie.
- Choroba koronawirusowa 2019 (COVID-19) – wprowadzenie
- Spektrum objawów COVID-19
- Najczęstsze objawy COVID-19
- Rzadsze objawy COVID-19
- Objawy alarmowe wymagające natychmiastowej pomocy medycznej
- Wystąpienie i progresja objawów COVID-19
- Ciężkość objawów i przebieg kliniczny
- Long COVID (długotrwały COVID-19)
- Definicja i częstość występowania Long COVID
- Objawy Long COVID
- Czynniki ryzyka Long COVID
- Wpływ Long COVID na jakość życia
- COVID-19 w szczególnych populacjach
- Różnice między COVID-19 a innymi infekcjami
- Choroba koronawirusowa 2019 (COVID-19) – monitoring objawów
Choroba koronawirusowa 2019 (COVID-19) – wprowadzenie
Choroba koronawirusowa 2019 (COVID-19) to choroba zakaźna wywoływana przez wirus SARS-CoV-2, który może być wysoce zakaźny i szybko się rozprzestrzenia12. COVID-19 powoduje głównie infekcję dróg oddechowych, atakując nos, gardło i płuca, ale może również wpływać na inne narządy34. Objawy choroby mogą wahać się od łagodnych do ciężkich, a niektóre osoby zakażone mogą nie wykazywać żadnych objawów56.
Spektrum objawów COVID-19
Osoby z COVID-19 mogą doświadczać szerokiego zakresu objawów – od łagodnych do ciężkich. COVID-19 może przebiegać jako choroba bezobjawowa, łagodna, umiarkowana, ciężka lub krytyczna178. Badania sugerują, że około 81% przypadków COVID-19 to przypadki łagodne, 14% to przypadki ciężkie, a 5% to przypadki krytyczne910.
Zasięg objawów COVID-19 może być różny w zależności od wariantu wirusa, szczepienia oraz indywidualnych cech pacjenta1112. Typowe objawy raportowane podczas fali wariantu Omikron obejmowały katar, ból głowy, kichanie i ból gardła, co różniło się od dominujących objawów we wcześniejszych fazach pandemii, które obejmowały gorączkę, kaszel, dreszcze i bóle mięśniowe12.
Najczęstsze objawy COVID-19
Do najczęstszych objawów COVID-19 należą1751314:
- Gorączka lub dreszcze114
- Kaszel (suchy lub z odkrztuszaniem)713
- Duszność lub trudności w oddychaniu15
- Zmęczenie lub wyczerpanie713
- Bóle mięśni lub ciała17
- Ból głowy15
- Utrata lub zaburzenie smaku i węchu17
- Ból gardła114
- Przekrwienie lub wyciek z nosa17
- Nudności lub wymioty15
- Biegunka15
Według przeglądu danych z 2020 roku, obejmującego prawie 25 000 dorosłych, najczęstszym objawem COVID-19 była gorączka, występująca u około 78% przypadków15. Inne badania wskazują, że najczęstszymi objawami były: zmęczenie (68,3%), zaburzenia węchu i smaku (64,4%), kaszel (60,4%), bóle mięśni (44,6%), duszność (41,1%), ból głowy (42,6%) i ból gardła (31,2%)16.
Rzadsze objawy COVID-19
Do mniej powszechnych objawów COVID-19 zaliczamy21417:
- Ciężkie uczucie w ramionach lub nogach2
- Zawroty głowy2
- Ucisk w klatce piersiowej lub ból w klatce piersiowej2
- Chrypka2
- Drętwienie lub mrowienie2
- Utrata apetytu213
- Ból brzucha218
- Przebarwienia skóry, palców rąk lub stóp1417
- Zaczerwienienie lub podrażnienie oczu1419
- Wysypka skórna1417
Objawy alarmowe wymagające natychmiastowej pomocy medycznej
W przypadku wystąpienia następujących objawów należy natychmiast szukać pomocy medycznej113215:
- Trudności w oddychaniu lub ciężka duszność, zwłaszcza w spoczynku12
- Uporczywy ból lub ucisk w klatce piersiowej113
- Nowe stany splątania, zaburzeń świadomości113
- Niemożność obudzenia się lub pozostania przytomnym113
- Sinica – blade, szare lub niebieskie zabarwienie ust, paznokci lub skóry (w zależności od tonu skóry)120
- Odkrztuszanie krwi13
- Omdlenia, zasłabnięcia lub drgawki13
Wystąpienie i progresja objawów COVID-19
Okres inkubacji i pojawienie się objawów
Objawy COVID-19 zazwyczaj pojawiają się 2-14 dni po ekspozycji na wirusa, najczęściej po 5-6 dniach11514. W przypadku wariantu Omikron okres inkubacji był krótszy – mediana wynosiła 2-4 dni1221.
Pierwsze objawy COVID-19 mogą być różne u różnych osób, jednak badania sugerują, że pierwszym objawem jest najczęściej gorączka, w przeciwieństwie do grypy, która zazwyczaj zaczyna się od kaszlu1522. Według badania z University of Southern California, objawy COVID-19 najczęściej pojawiają się w następującej kolejności2223:
- Gorączka
- Kaszel
- Ból gardła, ból mięśni lub ból głowy
- Nudności lub wymioty
- Biegunka
Warto jednak zaznaczyć, że przebieg choroby może się znacznie różnić między pacjentami, a niektórzy mogą doświadczać objawów w innej kolejności2223.
Progresja objawów w czasie
COVID-19 może postępować od łagodnych objawów do poważniejszych w miarę rozwoju choroby1. Badania wskazują na następującą potencjalną progresję choroby2424:
- Dzień 1: Pojawienie się łagodnych objawów, takich jak niska gorączka lub zmęczenie24
- Dzień 2: Nasilenie zmęczenia, pojawienie się podrażnienia gardła24
- Dzień 3: Pojawienie się objawów ze strony układu oddechowego, takich jak suchy kaszel i możliwe łagodne trudności w oddychaniu24
- Dzień 4-5: Nasilenie objawów; gorączka, kaszel i zmęczenie stają się bardziej intensywne24
- Dzień 6: Potencjalne pojawienie się objawów ze strony przewodu pokarmowego, takich jak nudności lub biegunka24
- Dzień 7: Nasilenie objawów, które mogą obejmować trudności w oddychaniu i uporczywy ból w klatce piersiowej24
- Dzień 8-10: U niektórych pacjentów objawy mogą osiągnąć szczyt, w tym wysoka gorączka i znaczny dystres oddechowy24
- Dzień 11-12: Stabilizacja objawów; wymagane monitorowanie pod kątem poprawy lub pogorszenia24
- Dzień 13-14: Niektóre osoby mogą zacząć zauważać stopniową poprawę, szczególnie jeśli zastosowano odpowiednią opiekę wspomagającą i leczenie24
- Dzień 15-20: Kontynuacja poprawy ze znacznym zmniejszeniem objawów i zwiększeniem poziomu energii24
- Dzień 21: Większość osób może powrócić do normalnych aktywności, jeśli objawy ustąpiły, choć zmęczenie może się utrzymywać24
U niektórych pacjentów z COVID-19 objawy mogą się nasilić około 7-14 dni po ich pojawieniu się7. Wśród pacjentów, którzy rozwinęli ciężką chorobę we wczesnej fazie pandemii, mediany czasu do wystąpienia duszności wahały się od 5 do 8 dni; mediany czasu do ostrego zespołu niewydolności oddechowej (ARDS) wahały się od 8 do 12 dni; a mediany czasu do przyjęcia na oddział intensywnej terapii wahały się od 10 do 12 dni8.
Czas trwania objawów
Czas trwania objawów COVID-19 może być różny. Łagodne do umiarkowanych objawy COVID-19 zazwyczaj utrzymują się do 2 tygodni1525. Wczesne badania sugerowały, że powrót do zdrowia po łagodnej chorobie może trwać dwa tygodnie, a po ciężkich lub krytycznych przypadkach nawet do sześciu tygodni25.
Według badań, objawy wariantu Omikron trwały krócej niż w przypadku wariantu Delta (średnio 7 dni w porównaniu do 9 dni)12. Jednak około dwie piąte pacjentów (40,7%) nadal zgłaszało przynajmniej jeden objaw 12 miesięcy po wystąpieniu choroby26.
Większość ludzi czuje się lepiej w ciągu kilku tygodni, ale u niektórych osób powrót do zdrowia może trwać dłużej13. Zmęczenie, ból głowy i problemy z oddychaniem należą do objawów, które najprawdopodobniej będą się utrzymywać25.
Ciężkość objawów i przebieg kliniczny
Stopnie ciężkości COVID-19
COVID-19 może mieć różne stopnie ciężkości, od bezobjawowego do krytycznego. Według wytycznych National Institutes of Health, stopnie ciężkości COVID-19 można sklasyfikować następująco817:
- Bezobjawowy: Osoby, które mają pozytywny wynik testu na SARS-CoV-2, ale nigdy nie rozwijają objawów zgodnych z COVID-198
- Przedobjawowy: Pacjenci wydają się być zakaźni krótko przed wystąpieniem objawów8
- Łagodna choroba: Osoby, które mają którekolwiek z różnych objawów COVID-19, ale nie mają duszności, trudności w oddychaniu lub nieprawidłowych wyników obrazowania klatki piersiowej8
- Umiarkowana choroba: Osoby, które wykazują objawy choroby dolnych dróg oddechowych podczas oceny klinicznej lub obrazowania i mają SpO₂ ≥94% w powietrzu pokojowym na poziomie morza8
- Ciężka choroba: Osoby, które mają SpO₂ <94% w powietrzu pokojowym na poziomie morza, stosunek ciśnienia parcjalnego tlenu w tętnicach (PaO₂) do frakcji wdychanego tlenu (FiO₂) 30/min lub nacieki płucne >50%8
- Krytyczna choroba: Osoby, które mają niewydolność oddechową, wstrząs septyczny lub dysfunkcję wielu narządów8
Według danych z badań, około 81% przypadków COVID-19 to przypadki łagodne do umiarkowanych (do łagodnego zapalenia płuc), 14% to przypadki ciężkie (duszność, hipoksja lub >50% zajęcia płuc w obrazowaniu), a 5% to przypadki krytyczne (niewydolność oddechowa, wstrząs septyczny lub niewydolność wielonarządowa)1010.
Czynniki ryzyka ciężkiego przebiegu COVID-19
Niektóre osoby są bardziej narażone na ciężki przebieg COVID-19. Czynniki ryzyka ciężkiego przebiegu obejmują8202728:
- Wiek – ryzyko znacznie wzrasta w wieku około 60-70 lat829
- Brak szczepienia lub dawno otrzymane szczepienie1229
- Choroby współistniejące829:
- Choroby serca
- Nadciśnienie tętnicze
- Cukrzyca
- Otyłość
- Przewlekłe choroby płuc lub dróg oddechowych
- Nowotwory
- Przewlekła choroba nerek
- Stany obniżonej odporności
- Płeć męska – według danych CDC, wśród 1482 pacjentów hospitalizowanych z powodu COVID-19, 54,4% stanowili mężczyźni8
Ryzyko ciężkiej choroby wzrasta wraz z liczbą, ciężkością i charakterem chorób współistniejących29. Badania porównujące COVID-19 z grypą wykazały, że COVID-19 był częstszy wśród mężczyzn (OR=1,46) i osób z wyższym wskaźnikiem masy ciała (MD=1,43)30.
Powikłania COVID-19
COVID-19 może prowadzić do różnych powikłań, które mogą być krótko- lub długoterminowe759. Do najczęstszych powikłań należą:
- Zapalenie płuc39
- Ostry zespół niewydolności oddechowej (ARDS)98
- Uszkodzenie serca i zaburzenia rytmu serca928
- Zakrzepy krwi, w tym zatorowość płucna (PE) lub zakrzepica żył głębokich (DVT)528
- Wstrząs septyczny910
- Niewydolność wielonarządowa, w tym uszkodzenie wątroby i nerek92
- Długotrwała utrata smaku i węchu7
- Wysypki skórne i zmiany skórne7
- Zespół wieloukładowego stanu zapalnego u dzieci (MIS-C) i dorosłych (MIS-A)73132
Według danych z 81 śmiertelnych przypadków pacjentów z Wuhan, najczęstszą przyczyną zgonu była niewydolność oddechowa (46,91%), następnie wstrząs septyczny (19,75%), niewydolność wielonarządowa (16,05%) i zatrzymanie akcji serca (8,64%)18.
COVID-19 może zwiększyć ryzyko poważnych problemów zdrowotnych przez co najmniej 12 miesięcy po zachorowaniu, w tym znacznie zwiększone ryzyko ataków serca, udarów, zapalenia serca, zakrzepów krwi w płucach lub innych miejscach, uszkodzenia nerek i poważnych problemów ze zdrowiem psychicznym29.
Long COVID (długotrwały COVID-19)
Definicja i częstość występowania Long COVID
Long COVID, znany również jako zespół po-COVID-19 (post-COVID-19 condition, PCC), odnosi się do szerokiego zakresu objawów i schorzeń, które niektóre osoby doświadczają cztery lub więcej tygodni po początkowej infekcji SARS-CoV-2332. Objawy te mogą utrzymywać się przez tygodnie, miesiące lub lata33.
Różne definicje Long COVID obejmują346:
- Według Centers for Disease Control and Prevention, Long COVID definiuje się jako następstwa, które utrzymują się przez co najmniej trzy miesiące po początkowej infekcji34
- Inne badania sugerują, że post-ostry COVID-19 to objawy utrzymujące się do 120 dni po wyzdrowieniu34
- W Australii Long COVID definiuje się jako utrzymywanie się objawów COVID-19 po 12 tygodniach6
Szacuje się, że od 5% do 50% pacjentów z COVID-19 doświadcza Long COVID19. Badania sugerują, że około 17,6 miliona Amerykanów ma Long COVID25, a około jedna trzecia osób z COVID-19 miała utrzymujące się objawy przez nawet 9 miesięcy po infekcji17.
Choroba dotyka około 5-10% osób zakażonych SARS-CoV-2, które nadal doświadczają objawów utrzymujących się ponad 3 miesiące po początkowej infekcji lub rozwijają nowe objawy tygodnie do miesięcy po diagnozie29.
Objawy Long COVID
Objawy Long COVID mogą się różnić od objawów ostrego COVID-19 i mogą znacznie się różnić między pacjentami6. Objawy mogą być uporczywe (rozwinęły się podczas ostrej choroby COVID-19 i nie ustąpiły), nawracające (mogą ustąpić po początkowej chorobie, a następnie powrócić) lub nowe (nie były obecne początkowo, ale rozwinęły się później)33.
Najczęstsze objawy Long COVID obejmują3363434:
- Skrajne zmęczenie (asthenia)633
- Duszność634
- Problemy z pamięcią i koncentracją (tzw. „mgła mózgowa”)633
- Kołatanie serca633
- Ból lub ucisk w klatce piersiowej633
- Kaszel635
- Zmiany w smaku i węchu635
- Ból stawów i mięśni634
- Drętwienie lub mrowienie635
- Zmiany nastroju (lęk, depresja lub stres)635
- Bóle głowy3635
- Zaburzenia snu3335
- Objawy żołądkowo-jelitowe, w tym ból brzucha, biegunka i/lub zaparcia3335
- Nawracające gorączki35
- Wysypki35
- Zmiany w cyklu miesiączkowym3335
Badania wykazały, że zmęczenie, duszność i ból stawów są najczęstszymi utrzymującymi się objawami po ostrym COVID-1934. Według Światowej Organizacji Zdrowia (WHO), najczęściej zgłaszane objawy PCS obejmują zmęczenie, zmieniony węch/anosmię i lęk37.
Czynniki ryzyka Long COVID
Long COVID może dotknąć każdego, w tym dzieci, i może rozwinąć się u osób, które miały bezobjawowy, łagodny lub ciężki COVID-1933. Jednak niektóre osoby są bardziej narażone na ryzyko, w tym332629:
- Osoby po ciężkim COVID-192928
- Osoby nieszczepione2938
- Kobiety – płeć żeńska jest jednym z najważniejszych determinantów szybkości powrotu do zdrowia po objawach26
- Osoby z otyłością – otyłość jest jednym z najważniejszych determinantów szybkości powrotu do zdrowia po objawach26
Badania wykazały, że odsetek uczestników, którzy zgłaszali co najmniej 1 utrzymujący się objaw 12 tygodni po wystąpieniu choroby, był większy u osób z ciężką/krytyczną chorobą (86,7%) w porównaniu do osób z łagodną lub umiarkowaną chorobą (odpowiednio 30,7% i 63,8%)26.
Wpływ Long COVID na jakość życia
Long COVID może mieć istotny wpływ na jakość życia i codzienne funkcjonowanie3329. Objawy Long COVID mogą wahać się od łagodnych do wyniszczających33.
Niektóre osoby zgłaszają, że objawy Long COVID uniemożliwiają im powrót do pracy lub szkoły, a inne mają trudności z wykonywaniem codziennych obowiązków lub nawet chodzeniem na krótkie dystanse3333. Znaczna część osób doświadcza objawów na tyle ciężkich, że wpływają one na ich zwykłe aktywności29.
Badania porównujące dzieci z i bez wcześniejszych infekcji wykazały, że choć większość objawów związanych z PCS nie różniła się między grupami, wydajność fizyczna i problemy poznawcze wydawały się być bardziej upośledzone po infekcji wariantem Omikron niż w grupie kontrolnej3737.
COVID-19 w szczególnych populacjach
COVID-19 u dzieci
Objawy COVID-19 u dzieci są zazwyczaj łagodniejsze niż u dorosłych1816. Dzieci zwykle prezentują łagodne objawy, bez gorączki lub zapalenia płuc, a czas powrotu do zdrowia szacuje się na 1-2 tygodnie po pojawieniu się choroby1816.
Dzieci mogą prezentować podobne objawy jak dorośli, ale częstość występowania poszczególnych objawów może być różna16. Gorączka i kaszel wydają się być najczęstszymi objawami COVID-19, zgłaszanymi u dzieci16.
Rzadkim, ale poważnym powikłaniem COVID-19 u dzieci jest wieloukładowy zespół zapalny (MIS-C)313239. Objawy MIS-C mogą wystąpić dwa lub więcej tygodni po ostrym COVID-19 i obejmują32:
- Gorączkę32
- Przekrwienie oczu32
- Wysypkę skórną32
- Zapalenie błony śluzowej jamy ustnej32
- Ból brzucha32
- Biegunkę32
- Wymioty32
- Trudności z karmieniem (u niemowląt)32
W ciężkich przypadkach MIS-C mogą wystąpić32:
- Zmiana koloru skóry – stawanie się bladym, plamistym i/lub niebieskim32
- Problemy z oddychaniem lub bardzo szybkie oddychanie32
- Przyspieszona akcja serca lub ból w klatce piersiowej32
- Zmniejszona ilość lub częstotliwość oddawania moczu32
- Splątanie, nieprawidłowe zachowanie lub trudności z wybudzeniem się32
COVID-19 u osób starszych
Osoby starsze są bardziej narażone na ciężki przebieg COVID-19108. Ryzyko znacznie wzrasta w wieku około 60-70 lat29.
Objawy, które mogą prezentować się inaczej u osób starszych, obejmują12:
- Gorączka (może wystąpić z niższymi temperaturami)12
- Kaszel i duszność (należy odróżnić od przewlekłych chorób płuc)12
- Utrata smaku lub węchu (należy odróżnić, czy jest spowodowana lekami lub procesami neurodegeneracyjnymi powodującymi upośledzenie sensoryczne)12
- Zmęczenie i bóle ciała (powszechne u osób starszych)12
W wieloośrodkowym badaniu przeprowadzonym w siedmiu oddziałach ratunkowych w USA, majaczenie było jednym z objawów prezentacyjnych u 226 (28%) z 817 pacjentów z COVID-19 i wyłącznie główną skargą prezentacyjną u 16% pacjentów ze średnią wieku 78 lat12.
COVID-19 w ciąży
Ciąża powoduje zmiany w organizmie, które mogą ułatwić zachorowanie na bardzo ciężkie choroby układu oddechowego, takie jak ta wywoływana przez wirusa wywołującego COVID-1940. Osoby w ciąży i te, które niedawno były w ciąży, narażone są na zwiększone ryzyko, jeśli zachorują na COVID-1940.
Ryzyko te obejmują40:
- Wyższe ryzyko ciężkiej choroby lub śmierci z powodu COVID-1940
- Większe prawdopodobieństwo przyjęcia do szpitala lub na oddział intensywnej terapii (OIOM)40
- Większe prawdopodobieństwo potrzeby respiratora lub specjalnego sprzętu pomagającego w oddychaniu40
- Wyższe ryzyko przedwczesnego porodu i martwego urodzenia40
- Może występować wyższe ryzyko innych powikłań ciąży, takich jak stan przedrzucawkowy/rzucawka, zakrzepy krwi, problemy z krwawieniem po porodzie, problemy z sercem i poród przez cesarskie cięcie40
Różnice między COVID-19 a innymi infekcjami
Objawy COVID-19 mogą nakładać się z objawami innych infekcji wirusowych, w tym grypy i innych infekcji wirusowych układu oddechowego i jelitowego1231. Jednak istnieją pewne różnice, które mogą pomóc w rozróżnieniu COVID-19 od innych chorób2224.
Badania porównujące COVID-19 i grypę wykazały następujące różnice3030:
- Pacjenci z COVID-19 częściej mieli biegunkę (OR=1,65), podczas gdy katar (OR=0,38), odkrztuszanie (OR=0,29), kaszel (OR=0,54) i ból gardła (OR=0,64) były bardziej powszechne wśród pacjentów z grypą30
- Liczba płytek krwi (SMD=0,42), hemoglobina (SMD=0,24) i poziomy ALT (SMD=0,35) były wyższe u pacjentów z COVID-19 niż u pacjentów z grypą30
- Pacjenci z COVID-19 byli bardziej narażeni na rozwój cukrzycy (OR=1,09)30
- Pacjenci z COVID-19 mieli dłuższe pobyty w szpitalu (MD=3,20) i na OIT (MD=3,10), częściej wymagali wentylacji mechanicznej (OR=2,30) i mieli wyższą śmiertelność (OR=2,22)30
Badania sugerują również, że w przeciwieństwie do grypy, która zazwyczaj zaczyna się od kaszlu, pierwszym objawem COVID-19 jest zazwyczaj gorączka2241. Ponadto, COVID-19 ma tendencję do rozwijania się bardziej stopniowo i różnorodnie niż grypa24.
Objawy COVID-19 utrzymują się dłużej niż objawy grypy lub zapalenia płuc, a objawy takie jak zmęczenie, duszność i ból stawów są najczęstszymi utrzymującymi się objawami po ostrym COVID-193434.
Choroba koronawirusowa 2019 (COVID-19) – monitoring objawów
Osoby z objawami COVID-19 powinny monitorować swój stan i szukać pomocy medycznej, gdy jest to konieczne1320. Jeśli objawy się nasilają, zwłaszcza w przypadku objawów alarmowych, należy natychmiast szukać pomocy medycznej113.
Większość osób z łagodnym lub umiarkowanym COVID-19 może wrócić do zdrowia w domu35. Można wrócić do normalnych aktywności, gdy poczujesz się lepiej lub nie masz gorączki1342. Jednak niektóre osoby mogą doświadczać objawów, które utrzymują się przez dłuższy czas43.
CDC zaleca, aby osoby z COVID-19 pozostały w izolacji przez co najmniej 5 dni po wystąpieniu objawów, a następnie nosiły maskę przez dodatkowe 5 dni21. Według brytyjskiego NHS, można wrócić do normalnych aktywności, gdy czujesz się lepiej lub nie masz wysokiej temperatury13.
U osób z wysokim ryzykiem ciężkiej choroby, które doświadczają objawów COVID-19, zaleca się wczesne leczenie, które może pomóc zmniejszyć ryzyko hospitalizacji4440. Leczenie musi być rozpoczęte w ciągu 5-7 dni od pojawienia się pierwszych objawów44.
Kolejne rozdziały
Zapraszamy do dalszego czytania naszego leksykonu.
Wybierz kolejny rozdział z menu poniżej, aby otworzyć nową podstronę kompedium wiedzy i uzyskać szczegółowe informację o leku, substancji lub chorobie.
Materiały źródłowe
- #1 Symptoms of COVID-19 | COVID-19 | CDChttps://www.cdc.gov/covid/signs-symptoms/index.html
People with COVID-19 have a wide range of symptoms ranging from mild symptoms to severe illness. […] Symptoms may appear 2-14 days after exposure to the virus. […] Symptoms may start as mild, and some people will progress to more severe symptoms. […] Possible symptoms include: Fever or chills, Cough, Shortness of breath or difficulty breathing, Sore throat, Congestion or runny nose, New loss of taste or smell, Fatigue, Muscle or body aches, Headache, Nausea or vomiting, Diarrhea. […] Look for emergency warning signs for COVID 19: Trouble breathing, Persistent pain or pressure in the chest, New confusion, Inability to wake or stay awake, Depending on skin tone, lips, nail beds and skin may appear pale, gray, or blue. […] COVID-19 (coronavirus disease 2019) is a disease caused by a virus named SARS-CoV-2. It can be very contagious and spreads quickly.
- #2https://www.who.int/news-room/fact-sheets/detail/coronavirus-disease-(covid-19)
COVID-19 is a disease caused by a virus. The most common symptoms are fever, chills, and sore throat, but there are a range of others. […] Symptoms usually begin 5-6 days after exposure and last 1-14 days. […] The most common symptoms are: fever, chills, sore throat. […] Less common symptoms are: muscle aches and heavy arms or legs, severe fatigue or tiredness, runny or blocked nose, or sneezing, headache, sore eyes, dizziness, new and persistent cough, tight chest or chest pain, shortness of breath, hoarse voice, numbness or tingling, appetite loss, nausea, vomiting, abdominal pain or diarrhoea, loss or change of sense of taste or smell, difficulty sleeping. […] People with the following symptoms should seek immediate medical attention: difficulty breathing, especially at rest, or unable to speak in sentences, confusion, drowsiness or loss of consciousness, persistent pain or pressure in the chest, skin being cold or clammy, or turning pale or a bluish colour, loss of speech or movement.
- #2https://www.who.int/news-room/fact-sheets/detail/coronavirus-disease-(covid-19)
People with severe disease and those needing hospital treatment should receive treatment as soon as possible. The consequences of severe COVID-19 include death, respiratory failure, sepsis, thromboembolism (blood clots), and multiorgan failure, including injury of the heart, liver or kidneys. […] Some people who have had COVID-19, whether they have needed hospitalization or not, continue to experience symptoms. These long-term effects are called long COVID (or post COVID-19 condition). The most common symptoms associated with long COVID include fatigue, breathlessness and cognitive dysfunction (for example, confusion, forgetfulness, or a lack of mental focus or clarity). Long COVID can affect a person’s ability to perform daily activities such as work or household chores.
- #3 Coronavirus & COVID-19 Overview: Symptoms, Risks, Prevention, Treatment & Morehttps://www.webmd.com/covid/coronavirus
COVID-19 is a disease caused by SARS-CoV-2 that can trigger what doctors call a respiratory tract infection. It can affect your upper respiratory tract (sinuses, nose, and throat) or lower respiratory tract (windpipe and lungs). […] The main symptoms include: Fever, Coughing, Shortness of breath, Trouble breathing, Fatigue, Chills, sometimes with shaking, Body aches, Headache, Sore throat, Congestion/runny nose, Loss of smell or taste, Nausea, Diarrhea. […] The virus can lead to pneumonia, respiratory failure, heart problems, liver problems, septic shock, and death. Many COVID-19 complications may be caused by a condition known as cytokine release syndrome or a cytokine storm. […] If you notice the following severe symptoms in yourself or a loved one, get medical help right away: Trouble breathing or shortness of breath, Ongoing chest pain or pressure, Confusion, Can’t wake up fully, Bluish lips or face.
- #4 Mild to moderate COVID-19 – discharge – UF Healthhttps://ufhealth.org/care-sheets/mild-to-moderate-covid-19-discharge
You have recently been diagnosed with coronavirus disease 2019 (COVID-19). COVID-19 causes an infection in your lungs and may cause problems with other organs, including the kidneys, heart, and liver. Most often it causes a respiratory illness with fever, coughing, and shortness of breath. You may have mild to moderate symptoms or severe illness. […] Symptoms occur within 2 to 14 days from exposure to the virus and may include fever, cough, shortness of breath, chills, muscle pain, headache, sore throat, and new loss of sense of taste or smell. COVID-19 may be more severe in people who are older or who have chronic health conditions, such as heart disease or diabetes.
- #5 Coronavirus Disease (COVID-19): Symptoms & Treatmenthttps://my.clevelandclinic.org/health/diseases/21214-coronavirus-covid-19
COVID-19 is an illness caused by the SARS-CoV-2 virus. Symptoms include fever, cough, shortness of breath, runny or stuffy nose, body aches and more. COVID can cause mild to severe illness. COVID symptoms can range from mild and cold-like to severe and life-threatening. COVID symptoms include: Fever, Sore throat, Headache, Tiredness (fatigue), Body aches, Chills, Stuffy or runny nose, Cough, Shortness of breath, Loss of or altered sense of smell and taste, Difficulty thinking and focusing (brain fog), Digestive symptoms, like diarrhea, nausea and vomiting. COVID can cause serious complications, even if you dont feel very sick. These include: Pneumonia, Acute respiratory distress syndrome (ARDS), Blood clots, including pulmonary embolism (PE) or deep vein thrombosis (DVT), Heart inflammation (myocarditis/pericarditis), Cardiac arrest, Multisystem inflammatory syndrome in children (MIS-C), Long COVID, a condition where pain, extreme fatigue and other symptoms last for months or years after a COVID infection. Many people recover from symptoms like congestion, sore throat and cough in about two weeks. But tiredness, shortness of breath and other symptoms can linger for weeks or even months afterwards. The outlook for COVID is different for everyone. Some people have only mild symptoms. Some get very sick and need to be hospitalized. Sometimes, your symptoms seem to get better and then get much worse. Always seek emergency medical attention for severe symptoms, no matter when they happen.
- #6 COVID-19 symptoms, spread and prevention | Australian Government Department of Health and Aged Carehttps://www.health.gov.au/topics/covid-19/about
COVID-19 symptoms range from mild or moderate to severe. […] Common symptoms include: fever, cough, sore throat, shortness of breath. […] It is possible to have COVID-19 and not show any symptoms, or only have very mild symptoms. […] When COVID-19 symptoms persist after 12 weeks, this is called long COVID. Some people are at greater risk of long COVID. […] Long COVID symptoms are not the same as COVID-19 symptoms and can vary greatly between people. Symptoms can include: extreme fatigue (tiredness), shortness of breath, heart palpitations, chest pain or tightness, cough, problems with memory and concentration, changes to taste and smell, joint and muscle pain, numbness or pins and needles, changes in mood (anxiety, depression or stress).
- #7 Coronavirus disease 2019 (COVID-19) – Symptoms and causes – Mayo Clinichttps://www.mayoclinic.org/diseases-conditions/coronavirus/symptoms-causes/syc-20479963
People may only have a few symptoms or none. People who have no symptoms but test positive for COVID-19 are called asymptomatic. […] Most people with COVID-19 have mild to moderate symptoms. But COVID-19 can cause serious medical complications and lead to death. Older adults or people who already have medical conditions are at greater risk of serious illness. […] COVID-19 may be a mild, moderate, severe or critical illness. […] Rarely, people who catch the coronavirus can develop a group of symptoms linked to inflamed organs or tissues. The illness is called multisystem inflammatory syndrome. […] Some people may have symptoms that get worse about 7 to 14 days after symptoms start. […] Complications of COVID-19 include long-term loss of taste and smell, skin rashes, and sores. The illness can cause trouble breathing or pneumonia. Medical issues a person already manages may get worse. […] After a COVID-19 infection, some people report that symptoms continue for months, or they develop new symptoms. This syndrome has often been called long COVID, or post-COVID-19. […] Researchers do think that post-COVID-19 syndrome can happen after an illness of any severity.
- #7 Coronavirus disease 2019 (COVID-19) – Symptoms and causes – Mayo Clinichttps://www.mayoclinic.org/diseases-conditions/coronavirus/symptoms-causes/syc-20479963
COVID-19, also called coronavirus disease 2019, is an illness caused by a virus. […] The virus that causes COVID-19 spreads most commonly through the air in tiny droplets of fluid between people in close contact. Many people with COVID-19 have no symptoms or mild illness. But for older adults and people with certain medical conditions, COVID-19 can lead to the need for care in the hospital or death. […] Typical COVID-19 symptoms often show up 2 to 14 days after contact with the virus. Symptoms can include: Dry cough. Shortness of breath. Loss of taste or smell. Extreme tiredness, called fatigue. Digestive symptoms such as upset stomach, vomiting or loose stools, called diarrhea. Pain, such as headaches and body or muscle aches. Fever or chills. Cold-like symptoms such as congestion, runny nose or sore throat.
- #8 Severity and Progression of Disease | ACEPhttps://www.acep.org/corona/covid-19-field-guide/diagnosis/severity-and-progression-of-disease
The median incubation period for COVID-19 is 4 to 5 days; the range is 2 to 14 days. Some variants, like Omicron, appear to cause symptoms sooner than the original virus. […] Studies suggest that illness severity can range from mild to critical: Asymptomatic: Individuals who test positive for SARS-CoV-2 using a virologic test but never develop symptoms that are consistent with COVID-19. Presymptomatic infection: Patients appear to be infectious shortly before they are symptomatic. Mild illness: Individuals who have any of the various signs and symptoms of COVID-19 but do not have shortness of breath, dyspnea, or abnormal chest imaging. Moderate illness: Individuals who show evidence of lower respiratory disease during clinical assessment or imaging and have an SpO2 94% on room air at sea level. Severe illness: Individuals who have an SpO2 94% on room air at sea level, a ratio of arterial partial pressure of oxygen (PaO2) to fraction of inspired oxygen (FiO2) 300 mm Hg, respiratory frequency 30 breaths/min, or lung infiltrates 50%. Critical illness: Individuals who have respiratory failure, septic shock, or multiple organ dysfunction.
- #8 Severity and Progression of Disease | ACEPhttps://www.acep.org/corona/covid-19-field-guide/diagnosis/severity-and-progression-of-disease
During the pandemic, some patients with COVID-19 rapidly deteriorated 1 week after illness onset. Among patients who developed severe disease early in the pandemic, the medium time to dyspnea ranged from 5 to 8 days; the median time to acute respiratory distress syndrome (ARDS) ranged from 8 to 12 days; and the median time to ICU admission ranged from 10 to 12 days, with 26% to 32% of patients admitted to the ICU. There have been different reports, but mortality among patients admitted to the ICU ranged from 39% to 72%. The median length of hospitalization among survivors was 10 to 13 days. […] As of 2023, the most significant risk factor for severe COVID-19 is a lack of previous immunity from vaccination or infection. Age is the second strongest risk factor for severe illness, complications, and death. According to the CDC reports from early in the pandemic, among the 1,482 patients hospitalized with COVID-19, 74.5% were aged 50 years, and 54.4% were of male sex. Heart disease, hypertension, prior stroke, diabetes, chronic lung or respiratory disease, cancer, leukemia, chronic kidney disease, and obesity have all been associated with increased illness severity and adverse outcomes.
- #9 Coronavirus Disease 2019 (COVID-19) Clinical Presentation: History, Physical Examination, Complicationshttps://emedicine.medscape.com/article/2500114-clinical
COVID-19 can manifest with a range of symptoms from mild to severe, such as fever, cough, shortness of breath, malaise, and respiratory distress, typically appearing 2 days to 2 weeks after exposure. […] The following symptoms may indicate COVID-19: Fever or chills, Cough, Shortness of breath or difficulty breathing, Fatigue, Muscle or body aches, Headache, New loss of taste or smell, Sore throat, Congestion or runny nose, Nausea or vomiting, Diarrhea. […] An extensive analysis by Wu and McGoogan revealed that 81% of COVID-19 cases were mild, 14% severe, 5% critical, and 2.3% fatal, with consistent findings observed across multiple studies. […] Complications of COVID-19 include pneumonia, acute respiratory distress syndrome, cardiac injury, arrhythmia, septic shock, liver dysfunction, acute kidney injury, and multi-organ failure, among others.
- #10 COVID-19 – Wikipediahttps://en.wikipedia.org/wiki/COVID-19
The symptoms of COVID-19 can vary but often include fever, fatigue, cough, breathing difficulties, loss of smell, and loss of taste. Symptoms may begin one to fourteen days after exposure to the virus. At least a third of people who are infected do not develop noticeable symptoms. Of those who develop symptoms noticeable enough to be classified as patients, most (81%) develop mild to moderate symptoms (up to mild pneumonia), while 14% develop severe symptoms (dyspnea, hypoxia, or more than 50% lung involvement on imaging), and 5% develop critical symptoms (respiratory failure, shock, or multiorgan dysfunction). Older people have a higher risk of developing severe symptoms. Some complications result in death. Some people continue to experience a range of effects (long COVID) for months or years after infection, and damage to organs has been observed. Multi-year studies on the long-term effects are ongoing.
- #10 COVID-19 – Wikipediahttps://en.wikipedia.org/wiki/COVID-19
The symptoms of COVID-19 are variable depending on the type of variant contracted, ranging from mild symptoms to a potentially fatal illness. Common symptoms include coughing, fever, loss of smell (anosmia) and taste (ageusia), with less common ones including headaches, nasal congestion and runny nose, muscle pain, sore throat, diarrhea, eye irritation, and toes swelling or turning purple, and in moderate to severe cases, breathing difficulties. People with the COVID-19 infection may have different symptoms, and their symptoms may change over time. […] Of people who show symptoms, 81% develop only mild to moderate symptoms (up to mild pneumonia), while 14% develop severe symptoms (dyspnea, hypoxia, or more than 50% lung involvement on imaging) that require hospitalization, and 5% of patients develop critical symptoms (respiratory failure, septic shock, or multiorgan dysfunction) requiring ICU admission.
- #11https://www.sandiegocounty.gov/content/sdc/hhsa/programs/phs/community_epidemiology/dc/2019-nCoV/about.html
People with COVID-19 have reported a wide span of symptoms ranging from mild to severe. Anyone can have mild to severe symptoms. Symptoms may appear 2-14 days after exposure to the virus. […] This list does not include all possible symptoms. Symptoms may change with new COVID-19 variants and can vary depending on vaccination status.
- #12 COVID-19 signs, symptoms and severity of disease: A clinician guide – Canada.cahttps://www.canada.ca/en/public-health/services/diseases/2019-novel-coronavirus-infection/guidance-documents/signs-symptoms-severity.html
COVID-19 includes clinical features that present in varying ways with respect to frequency and severity and vary by age, vaccination status and variants of concern. […] Symptoms that are absent at the onset of illness may develop over time with disease progression. […] Typical symptoms reported during the Omicron wave included runny nose, headache, sneezing, and sore throat. […] This response is different than the predominant symptoms earlier in the pandemic, which included fever, cough, chills and muscle pain. […] With the Omicron variant, loss or altered sense of smell is less prevalent than with the Delta variant, and sore throat and hoarse voice were significantly more prevalent. […] Those infected during the Omicron wave are less likely to experience at least one out of the three classic COVID-19 symptoms (fever, loss of smell, and persistent cough) compared with individuals infected during the Delta wave.
- #12 COVID-19 signs, symptoms and severity of disease: A clinician guide – Canada.cahttps://www.canada.ca/en/public-health/services/diseases/2019-novel-coronavirus-infection/guidance-documents/signs-symptoms-severity.html
Omicron has been found to have an incubation period of a median of 2-4 days, and its associated viral loads have been reported to peak in saliva 1-2 days before positive results can be seen in PCR or rapid antigen tests. […] There is a spectrum of COVID-19 disease severity, ranging from asymptomatic, mild, moderate, to severe and critical disease. […] Severe disease occurs more often in older age and in those with underlying medical conditions, and the risk increases with the number of underlying medical conditions.
- #12 COVID-19 signs, symptoms and severity of disease: A clinician guide – Canada.cahttps://www.canada.ca/en/public-health/services/diseases/2019-novel-coronavirus-infection/guidance-documents/signs-symptoms-severity.html
Duration of acute symptoms for those with the Delta variant was longer than those with the Omicron variant (mean duration 9 days vs. 7 days). […] Some people can present symptoms for weeks of months after their initial recovery. […] Patients with mild disease should be informed to seek medical attention should they experience any of the following: trouble breathing or severe shortness of breath, persistent pressure or pain in the chest, new onset of confusion or altered level of consciousness, inability to wake up or stay awake, pale, gray, or blue-colored skin, lips, or nail beds. […] Symptoms typically occur around 2-6 weeks after the initial infection. […] Symptoms typically occur around 2-12 weeks after the initial infection. […] Most patients with MIS-A presented with fever (96%), hypotension (60%), cardiac dysfunction (54%), shortness of breath (52%), and/or diarrhea (52%).
- #12 COVID-19 signs, symptoms and severity of disease: A clinician guide – Canada.cahttps://www.canada.ca/en/public-health/services/diseases/2019-novel-coronavirus-infection/guidance-documents/signs-symptoms-severity.html
Symptoms of COVID-19 may overlap with that of other viral infections, including influenza and other respiratory and enteric viral infections. […] Symptoms that may present differently in older individuals include: fever (may present with lower temperatures), cough and shortness of breath (differentiate from chronic lung conditions), loss of taste or smell (differentiate if due to medications or neurodegenerative processes causing sensory impairment), and fatigue and body ache (common in older individuals). […] In a multicenter study of seven emergency departments in the US, delirium was one of the presenting symptoms in 226 (28%) of 817 patients with COVID-19 and exclusively the primary presenting complaint in 16% of patients with a mean age of 78 years. […] The pre-Omicron incubation period for COVID-19 had been estimated to range from 2 to 14 days, with a median of 4-7 days from exposure to symptom onset.
- #13 COVID-19 symptoms and what to do – NHShttps://www.nhs.uk/conditions/covid-19/covid-19-symptoms-and-what-to-do/
COVID-19 symptoms can include: a high temperature or shivering (chills) a high temperature means you feel hot to touch on your chest or back (you do not need to measure your temperature) […] a new, continuous cough this means coughing a lot for more than an hour, or 3 or more coughing episodes in 24 hours […] a loss or change to your sense of smell or taste […] shortness of breath […] feeling tired or exhausted […] an aching body […] a headache […] a sore throat […] a blocked or runny nose […] loss of appetite […] diarrhoea […] feeling sick or being sick. […] The symptoms are very similar to symptoms of other illnesses, such as colds and flu. Most people feel better within a few weeks, but it can take longer to recover. For some people, it can be a more serious illness and their symptoms can last longer.
- #13 COVID-19 symptoms and what to do – NHShttps://www.nhs.uk/conditions/covid-19/covid-19-symptoms-and-what-to-do/
It’s particularly important to get help if you’re at increased risk of getting ill from COVID-19, such as if you’re pregnant, aged 60 or over, or have a weakened immune system. […] Immediate action required: Call 999 or go to AE if you or a child: seems very unwell, is getting worse or you think there’s something seriously wrong […] are so breathless you’re unable to say short sentences when resting or your breathing has suddenly got worse […] start coughing up blood […] collapse, faint, or have a seizure or fit for the first time.
- #13 COVID-19 symptoms and what to do – NHShttps://www.nhs.uk/conditions/covid-19/covid-19-symptoms-and-what-to-do/
Try to stay at home and avoid contact with other people if you or your child have symptoms and either: have a high temperature […] do not feel well enough to go to work, school, childcare, or do your normal activities. […] You can go back to your normal activities when you feel better or do not have a high temperature. If your child has mild symptoms such as a runny nose, sore throat or mild cough, and they feel well enough, they can go to school or childcare. […] If you have a cough, you can ask a pharmacist for advice about cough treatments. […] If you or your child have tested positive for COVID-19: try to stay at home and avoid contact with other people for 3 days after the day the test was taken if you or your child are under 18 years old […] try to stay at home and avoid contact with other people for 5 days after the day you took your test if you are 18 years old or over […] avoid meeting people who are more likely to get seriously ill from viruses, such as people with a weakened immune system, for 10 days after the day you took your test.
- #14https://www.who.int/health-topics/coronavirus
COVID-19 affects different people in different ways. Most infected people will develop mild to moderate illness and recover without hospitalization. […] Most common symptoms: fever, cough, tiredness, loss of taste or smell. […] Less common symptoms: sore throat, headache, aches and pains, diarrhoea, a rash on skin, or discolouration of fingers or toes, red or irritated eyes. […] Serious symptoms: difficulty breathing or shortness of breath, loss of speech or mobility, or confusion, chest pain. […] Seek immediate medical attention if you have serious symptoms. Always call before visiting your doctor or health facility. […] People with mild symptoms who are otherwise healthy should manage their symptoms at home. […] On average it takes 56 days from when someone is infected with the virus for symptoms to show, however it can take up to 14 days.
- #15 COVID-19 symptoms: Timeline and progressionhttps://www.medicalnewstoday.com/articles/progression-of-covid-19-symptoms
Fever is the most common symptom of COVID-19, occurring in around 78% of COVID-19 cases, according to a 2020 review of data from almost 25,000 adults. […] COVID-19 may then cause a cough, sore throat, body aches, and headaches. […] In severe cases, COVID-19 can require hospitalization. Some people will experience acute respiratory distress syndrome. This is where the lungs fail to provide the body with sufficient oxygen. […] The type and order of symptoms will vary from person to person. For example, some people will experience nausea, vomiting, or diarrhea before fever or coughing. Others will experience no symptoms at all. Symptoms may be more severe for some people. […] According to the Centers for Disease Control and Prevention (CDC), other COVID-19 symptoms could include chills, tiredness, loss of taste or smell, and nasal congestion.
- #15 COVID-19 symptoms: Timeline and progressionhttps://www.medicalnewstoday.com/articles/progression-of-covid-19-symptoms
Some people will experience severe symptoms, such as shortness of breath, confusion, chest pain or pressure, and difficulty moving or talking. People who experience these symptoms must seek immediate medical attention. […] Most people will experience no long-term effects from COVID-19. However, others may experience long COVID. This is where symptoms persist for several weeks or months. […] The duration of time that symptoms must persist to constitute long COVID varies. The CDC states that symptoms lasting 4 or more weeks constitute long COVID. […] COVID-19 can cause a range of symptoms for around two weeks. The order of these symptoms will vary from case to case. However, some research suggests fever is most likely to occur first. […] Some cases of COVID-19 cause severe symptoms, which typically emerge after around a week. People with these symptoms must seek immediate medical attention.
- #15 COVID-19 symptoms: Timeline and progressionhttps://www.medicalnewstoday.com/articles/progression-of-covid-19-symptoms
Mild to moderate COVID-19 symptoms typically last for up to 2 weeks. The timeline for symptoms can vary, but they usually begin 2-14 days after contact with the virus. A person may experience cold- or flu-like symptoms. […] The type, severity, and progression of COVID-19 symptoms will determine how COVID-19 affects a person’s daily living. Some people may experience no symptoms at all, while others will require treatment in a hospital. […] COVID-19 symptoms typically occur 2-14 days after exposure to the virus, most commonly after 5-6 days. Most people will experience mild-to-moderate symptoms during this period. […] The first COVID-19 symptom to develop is likely to be fever, which is a temporary increase in body temperature. This differs from influenza, where the first symptom is typically a cough.
- #16 What are the early symptoms of coronavirus (COVID-19)?https://www.medicalnewstoday.com/articles/coronavirus-early-symptoms
According to 2020 research, the prevalence of some of these symptoms appears to be: Dry cough 60.4%, Shortness of breath or breathing difficulties 41.1%, Fever 55.5%, Muscle pain 44.6%, Headache 42.6%, Sore throat 31.2%, Smell and taste disturbance 64.4%, Fatigue 68.3%. […] Symptoms of COVID-19 in children and young adults are more likely to be mild. […] Early symptoms of coronavirus infection in children are similar to those in adults. […] Fever and cough appear to be the common symptoms of COVID-19 that people report in children. […] Children with COVID-19 are likely to recover in 1 to 2 weeks with no additional issues. […] However, around 1 in 5 people with a coronavirus infection will become seriously unwell and develop breathing difficulties. […] If a person with COVID-19 has trouble breathing, or experiences other concerning symptoms, they should call 911 and seek medical attention.
- #17 Coronavirus (COVID-19): Symptoms, Transmission, Treatment and Morehttps://www.healthline.com/health/coronavirus-covid-19
COVID-19 may not cause any symptoms for some people. A December 2020 literature review estimated that 17% of people with COVID-19 are asymptomatic. This means they have no symptoms at all. […] Among those who do have symptoms, symptoms may appear 2 to 14 days after exposure. […] Some common symptoms linked to COVID-19 include: shortness of breath, a cough that gets more severe over time, congestion or runny nose, fever, chills, fatigue. […] Less common symptoms include: shivering, sore throat, headache, muscle aches and pains, loss of taste or smell, a stuffy or runny nose, gastrointestinal symptoms such as diarrhea, nausea, and vomiting, discoloration of fingers or toes, pink eye, rash. […] However, individuals with COVID-19 may have some, all, or none of the above symptoms. […] The most common symptom of COVID-19 is fever. However, a 2020 study involving 213 participants with mild disease found that only 11.6% of them had a fever.
- #17 Coronavirus (COVID-19): Symptoms, Transmission, Treatment and Morehttps://www.healthline.com/health/coronavirus-covid-19
Most people with COVID-19 will only have a mild case. According to the National Institutes of Healths COVID-19 treatment guidelines, people are said to have a mild case if they have any of the typical symptoms of COVID-19 (such as cough, fatigue, or loss of taste or smell) and do not have shortness of breath or atypical chest imaging. […] That said, mild cases can still have long-lasting effects. People who experience symptoms months after first contracting the virus and after it is no longer detectable are referred to as long haulers. […] According to a 2021 study, approximately one-third of people with COVID-19 had persistent symptoms for as long as 9 months after infection. […] That said, call emergency medical services if you or someone you care for has severe or life threatening symptoms such as difficulty breathing, chest pain, or confusion. […] Typically, symptoms will appear within 5 to 6 days of exposure and can persist between 1 and 14 days. Those who develop long covid may experience long-term symptoms for weeks, months, and sometimes years.
- #18 COVID-19: Specific and Non-Specific Clinical Manifestations and Symptoms: The Current State of Knowledgehttps://pmc.ncbi.nlm.nih.gov/articles/PMC7356953/
Coronavirus disease 2019 (COVID-19), due to the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has become an epidemiological threat and a worldwide concern. COVID-19 might present different degrees of severity from mild or even asymptomatic carriers, even to fatal cases. The most common complications include pneumonia and acute respiratory distress syndrome. Fever, dry cough, muscle weakness, and chest pain are the most prevalent and typical symptoms of COVID-19. However, patients might also present atypical symptoms that can occur alone, which might indicate the possible SARS-CoV-2 infection. The majority of patients with COVID-19 present common symptoms that include fever, shortness of breath, cough (either with or without sputum), sore throat, nasal congestion, dizziness, chills, muscle ache, arthralgia, weakness, fatigue or myalgia, chest tightness, excessive mucus production with expectoration, hemoptysis, and dyspnea. Even though fever is not the only initial clinical manifestation of SARS-CoV-2 infection, it is considered to be critical. Fever, cough, and fatigue are the three most prevalent symptoms in COVID-19 patients. Other less characteristic symptoms include headache, diarrhea, abdominal pain, vomiting, chest pain, rhinorrhoea, or pharyngalgia. Approximately 90% of the patients present more than one symptom. It is suggested that an early onset of shortness of breath constitutes a poor prognostic factor for patients. Among 81 fatal cases of patients from Wuhan, the most common cause of death was a respiratory failure (46.91%), followed by septic shock (19.75%), multiple organ failure (16.05%), and cardiac arrest (8.64%). Clinical characteristics might differ between critically ill and non-critically ill patients. COVID-19 patients tend to have normal or decreased white blood cell counts, lymphopenia, or thrombocytopenia. The most prevalent cardiovascular complication of COVID-19 is an acute myocardial injury (usually defined as an increase in cardiac troponin I above the 99th percentile upper reference limit), with a prevalence of 8%12%. The Kawasaki-like disease has been recently described as a post-infectious inflammatory syndrome that might constitute a complication of the COVID-19 disease, especially among pediatric patients. The amount of literature regarding clinical manifestations of COVID-19 in pediatric patients is continually increasing. Children usually present mild symptoms or might remain asymptomatic. Pediatric patients with other comorbid diseases are much more vulnerable to SARS-CoV-2 infection and a more severe course of COVID-19. Generally, the majority of pediatric patients have mild symptoms, without fever or pneumonia, and the recovery time is estimated to be 12 weeks after the onset of the disease.
- #19 COVID-19 pandemic – Wikipediahttps://en.wikipedia.org/wiki/COVID-19_pandemic
COVID-19 symptoms range from asymptomatic to deadly, but most commonly include fever, sore throat, nocturnal cough, and fatigue. […] Common symptoms include headache, loss of smell and taste, nasal congestion and runny nose, cough, muscle pain, sore throat, fever, diarrhoea, and breathing difficulties. […] In people without prior ear, nose, and throat disorders, loss of taste combined with loss of smell is associated with COVID-19 and is reported in as many as 88% of cases. […] The time between symptom onset and death ranges from 6 to 41 days, typically about 14 days. Mortality rates increase as a function of age. People at the greatest mortality risk are the elderly and those with underlying conditions. […] Between 5% and 50% of COVID-19 patients experience long COVID, a condition characterised by long-term consequences persisting after the typical convalescence period of the disease. […] The most commonly reported clinical presentations are fatigue and memory problems, as well as malaise, headaches, shortness of breath, loss of smell, muscle weakness, low fever and cognitive dysfunction.
- #20 COVID-19 symptoms Information | Mount Sinai – New Yorkhttps://www.mountsinai.org/health-library/symptoms/covid-19-symptoms
More severe symptoms that require seeking medical help right away include: Trouble breathing, Chest pain or pressure that persists, Confusion, Inability to wake up, Blue, gray, or pale skin, lips, face, or nail beds, depending on your skin tone. Older people and people with certain existing health conditions have a higher risk of developing severe illness and death. Health conditions that increase your risk include cancer, COPD, diabetes, heart disease and stroke, a weak immune system (immunocompromised), and many others.
- #21 Coronavirus Disease 2019 (COVID-19): Practice Essentials, Background, Route of Transmissionhttps://emedicine.medscape.com/article/2500132-overview
In a study that included 172 patients diagnosed with COVID-19 in January 2022, the estimated median incubation period was 2.8 days (SD, 1.20) among those infected with the Omicron variant (primarily sublineage BA.1). Most infections fell between 1 and 6 days. The distribution was significantly longer in patients with the Alpha variant (4.5 days), and the researchers previous study that used contact tracing data estimated a median incubation period of 3.7 days for the Delta variant. […] The following symptoms may indicate COVID-19: Fever or chills (43-45%), Cough (63-83%), Shortness of breath or difficulty breathing (45.6%), Fatigue (63%), Muscle or body aches (36-63%), Headache (34-70%), New loss of taste (54.2%) or smell (70.2%), Sore throat (52.9%), Congestion (67.8%) or runny nose (60.1%), Nausea or vomiting (31.6%), Diarrhea (17.8%).
- #21 Coronavirus Disease 2019 (COVID-19): Practice Essentials, Background, Route of Transmissionhttps://emedicine.medscape.com/article/2500132-overview
The data align with current recommendations from the World Health Organization (WHO) and the Centers for Disease Control and Prevention (CDC), advocating for a shortened isolation period of 5 days following symptom onset, supplemented by an additional 5 days of mask-wearing for COVID-19 patients. […] A systematic review conducted a comprehensive analysis of SARS-CoV-2 shedding patterns using viral culture data from studies up to February 16, 2023. […] The review identified that positive viral cultures were predominantly detected within 14 days of symptom onset, with peak shedding occurring between days 5 and 9 post-symptom onset or diagnosis.
- #22 New Covid Variants: Symptoms May Show Up In This Orderhttps://www.healthline.com/health-news/covid-19-symptoms-usually-show-up-in-this-order
According to the study, while influenza typically begins with a cough or muscle pain, the first symptom of COVID-19 is fever. […] It’s critically important to understand the progression of symptoms of people with the COVID-19 infection so you stop the spread of the disease in effect, isolate and then initiate effective contact tracing. […] In general, while fever is usually the most commonly described initial symptom of COVID-19 infection, the reality of what I see on the front lines is more variable. […] The onset of nausea, vomiting, and diarrhea after onset of respiratory symptoms such as fever and cough may also suggest that a person may have COVID-19. […] According to Glatter, healthcare professionals need to be vigilant and keep an open mind when evaluating patients who may have symptoms associated with COVID-19 particularly as new subvariants emerge.
- #22 New Covid Variants: Symptoms May Show Up In This Orderhttps://www.healthline.com/health-news/covid-19-symptoms-usually-show-up-in-this-order
COVID-19 symptoms often start in a certain order. […] While influenza typically begins with a cough, the first symptom of COVID-19 is generally fever, though symptoms may vary. […] Symptoms of COVID-19 may resemble common respiratory viruses, but there are some key differences. […] In general, COVID-19 symptoms may include upper respiratory tract symptoms such as fever, coughing, sneezing, and runny nose. […] If you display any of the above symptoms and test positive for COVID-19, you may have contracted one of the new subvariants and should self-isolate for at least 5 days, which is the current recommended period of isolation. […] A 2020 study from the University of Southern California (USC) shed light on how COVID-19 symptoms present, which may help individuals recognize whether their cough is just a cough or something worse. The researchers determined that COVID-19 symptoms often start in a certain order: fever, cough, sore throat, muscle pain, or headache, nausea or vomiting, diarrhea.
- #23 COVID-19 Symptoms May Follow a Specific Order, Study Findshttps://www.verywellhealth.com/covid-19-symptom-order-5076014
COVID-19 symptoms may appear in a specific order, usually starting with fever, according to a new study. […] The order in which COVID-19 symptoms appear may help medical providers distinguish the disease from other illnesses such as the flu, according to a new study from the University of Southern California. […] Researchers determined COVID-19 symptoms are most likely to follow this trajectory: Fever, Cough, Nausea/vomiting, Diarrhea. […] COVID-19 patients who did not follow the typical symptom progression and exhibited diarrhea first tended to have more severe cases of COVID-19. […] It’s important to remember that these are just predictions of what symptom progression may look like. COVID-19, in particular, can present very differently from other illnesses, and there is still much that remains unknown about the disease.
- #23 COVID-19 Symptoms May Follow a Specific Order, Study Findshttps://www.verywellhealth.com/covid-19-symptom-order-5076014
While researchers still can’t say there’s a „normal” symptom progression for COVID-19, data analysis indicates it often starts with a fever. […] If you suspect COVID-19, do not delay testing, regardless of the order in which your symptoms appear. Early identification aids in containing the spread of the virus.
- #24 How COVID-19 Symptoms Day-by-Day Evolve | +MEDRITEhttps://medriteurgentcare.com/covid-19-symptoms-day-by-day/
With the ongoing mutations and variations of COVID-19, itâs more important than ever to understand how the virus may affect us on a day-to-day basis. Rapid changes in symptoms can occur, and staying ahead means being able to recognize early signs and know when to act swiftly to seek medical intervention. […] Day 1: Onset of mild symptoms like low-grade fever or fatigue. […] Day 2: Increase in fatigue, onset of throat irritation. […] Day 3: Appearance of respiratory symptoms like dry cough and possible mild breathing difficulties. […] Day 4-5: Symptoms become more pronounced; fever, cough, and fatigue intensify. […] Day 6: Potential appearance of gastrointestinal symptoms like nausea or diarrhea. […] Day 7: Heightened symptoms which may include difficulty breathing and persistent chest pain.
- #24 How COVID-19 Symptoms Day-by-Day Evolve | +MEDRITEhttps://medriteurgentcare.com/covid-19-symptoms-day-by-day/
Day 8-10: Symptoms may peak, including high fever and significant respiratory distress. […] Day 11-12: Plateau of symptoms; monitoring required for any signs of improvement or worsening. […] Day 13-14: Some individuals may begin to notice gradual improvement, especially if supportive care and treatment are effective. […] Day 15-17: Marked improvement in symptoms; gradual reduction in fever, cough, and breathing difficulties. […] Day 18-20: Continued recovery with significant reduction in symptoms, increased energy levels. […] Day 21: Most individuals may return to normal activities if symptoms have resolved, though fatigue may linger. […] Many begin to see improvements post the first week, yet it remains essential to monitor for any fluctuations in symptoms or persisting fatigue, which could linger and affect daily activities.
- #24 How COVID-19 Symptoms Day-by-Day Evolve | +MEDRITEhttps://medriteurgentcare.com/covid-19-symptoms-day-by-day/
For some, symptoms extend beyond the usual two-week period, a phenomenon known as âLong COVIDâ, which varies greatly between individuals and may involve prolonged medical supervision. […] COVID-19 symptoms tend to develop more gradually and diversely than the flu, making vigilance and tailored responses essential. […] While several respiratory viruses share initial symptoms with COVID-19, the latterâs potential severity and long-term implications set it apart, requiring specific and immediate attention. […] Understanding each phase of symptom development can lead to more effective interventions and ultimately, better health outcomes.
- #25 Coronavirus Recovery: Rate, Time, & Outlookhttps://www.webmd.com/covid/covid-recovery-overview
Most people who get COVID-19, the disease caused by a coronavirus called SARS-CoV-2, will have only mild illness. But what exactly does that mean? […] COVID-19 lasts anywhere from a few days to a few weeks. Once symptoms (if you have them) clear up, it usually means that COVID-19 isn’t in your body anymore. Some people may develop long COVID a wide range of symptoms that last weeks, months, or years after COVID-19 illness. […] Not everyone who catches COVID will notice symptoms. If you do get them, they may show up 2-14 days after your infection. And those symptoms can vary from one person to the next. […] Symptoms may include: Fever (100.4 F or higher for adults) or chills, A dry cough (the kind that doesn’t bring up any mucus or phlegm) or a cough with mucus, Fatigue, Sore throat, Headache, Muscle and joint pain, Nausea, vomiting, or diarrhea, Chest tightness, Labored breathing, Shortness of breath, Loss of taste and/or sense of smell.
- #25 Coronavirus Recovery: Rate, Time, & Outlookhttps://www.webmd.com/covid/covid-recovery-overview
Early research suggested that it could take two weeks for your body to get over a mild illness or up to six weeks for severe or critical cases. Recovery varies for different people, depending on things like your age and overall health. Fatigue, headache, and troubled breathing are the symptoms most likely to linger. […] You’ll know you’re getting better once your symptoms lessen or disappear altogether. […] Long COVID happens when a range of symptoms linger after recovery and affect your quality of life. Experts estimate that 17.6 million Americans have long COVID. You may notice symptoms like: Mild headaches, Overall feeling of being unwell, Fatigue, Trouble concentrating, Shortness of breath. […] COVID-19 symptoms (if you have them) typically start 2-14 days after infection and clear up within a few days or weeks. The severity and length of illness varies from person to person, and there’s no certainty about how long COVID-19 stays in your body. Staying hydrated, eating healthy, and resting will help you recover faster. Contact your doctor if your symptoms are severe or last longer than a few weeks.
- #26 Evolution of Coronavirus Disease 2019 (COVID-19) Symptoms During the First 12 Months After Illness Onset – PubMedhttps://pubmed.ncbi.nlm.nih.gov/34473245/
Few robust longitudinal data on long-term coronavirus disease 2019 (COVID-19) symptoms are available. […] We evaluated symptom onset, severity and recovery across the full spectrum of disease severity, up to one year after illness onset. […] The proportion of participants who reported at least 1 persistent symptom at 12 weeks after illness onset was greater in those with severe/critical disease (86.7% [95% confidence interval {CI} = 76.5-92.7%]) compared to those with mild or moderate disease (30.7% [95% CI = 21.1-40.9%] and 63.8% [95% CI = 54.8-71.5%], respectively). […] At 12 months after illness onset, two-fifths of participants (40.7% [95% CI = 34.2-7.1]) continued to report 1 symptom. […] COVID-19 symptoms persisted for one year after illness onset, even in some individuals with mild disease. […] Female sex and obesity were the most important determinants of speed of recovery from symptoms.
- #27 COVID-19: symptoms, treatment, prevention – Institut Pasteurhttps://www.pasteur.fr/en/medical-center/disease-sheets/covid-19-sars-cov-2-virus
30 to 60% of people who carry the virus, especially young children, are asymptomatic. Others present mild, non-specific symptoms, including headache, fever, cough, diarrhea and fatigue. A sudden loss of smell and/or taste may occur in a number of infected individuals. […] COVID-19 may progress to severe respiratory distress, sometimes requiring hospitalization or treatment in intensive care. […] The most severe forms of the disease are mainly observed in elderly people and/or those with obesity, high blood pressure or diabetes. […] As well as the short-term effects, some symptoms chronic fatigue, neurological symptoms and breathing difficulties can last for several weeks or even months. This is known as long COVID.
- #28 COVID-19 – Infections – Merck Manual Consumer Versionhttps://www.merckmanuals.com/home/infections/covid-19/covid-19
COVID-19 is an acute respiratory illness that can be mild or severe and is caused by a coronavirus named SARS-CoV-2. […] Symptoms of COVID-19 vary significantly. […] Symptoms vary in people with COVID-19 and may include the following: Fever, Cough, Sore throat, Congestion or runny nose, Shortness of breath or difficulty breathing, Chills or repeated shaking with chills, New loss of smell or taste, Fatigue, Muscle pain, Headache, Nausea or vomiting, Diarrhea. […] If people develop symptoms, they usually appear about 2 to 10 days (incubation period) after being infected. For the Omicron variant, symptoms usually appear in only 2 to 4 days. Many infected people have no symptoms or have only mild disease. […] The risk of serious disease and death in people with COVID-19 increases with age, in people who smoke or previously smoked cigarettes, and in people with other serious medical disorders, such as cancer or chronic heart, lung, kidney, or liver disease, sickle cell disease, cystic fibrosis, diabetes, obesity, or immunocompromising disorders.
- #28 COVID-19 – Infections – Merck Manual Consumer Versionhttps://www.merckmanuals.com/home/infections/covid-19/covid-19
For all age groups, risk of serious disease and death decreases in people who are vaccinated against COVID-19. […] In addition to respiratory disease that can be severe and lead to death, other serious complications include heart disorders including arrhythmias, heart muscle disorders, and acute heart injury, coagulation disorders including blood clots in small and large blood vessels as well as bleeding, and Guillain-Barr syndrome (rare). […] Some people with COVID-19 develop Long COVID. Long COVID is defined as a chronic condition that occurs after SARS-CoV-2 infection and is present for at least 3 months. Long COVID includes a wide range of symptoms or conditions that may improve, worsen, or be ongoing. Long COVID occurs more often in people who had severe COVID-19 illness, but anyone who gets COVID-19 can experience it, including children.
- #29 COVID-19 (Coronavirus disease 2019) | health.vic.gov.auhttps://www.health.vic.gov.au/infectious-diseases/covid-19-coronavirus-disease-2019
COVID-19 usually presents with symptoms similar to other acute respiratory infections (ARI) as defined by recent onset of new or worsening of acute respiratory and other symptoms, such as: cough, runny nose, breathing difficulty, sore throat, chills and/or sweats, fever (37.5C) can occur but is less common in the elderly. […] Other symptoms may include: headache, muscle aches, fatigue, nausea, vomiting, diarrhoea, loss of smell and taste, loss of appetite. […] Symptoms can take days to weeks to resolve. Some people may have no symptoms. […] Increasing age is the most important risk factor for severe illness, with risk significantly increasing around 60-70 years of age. […] People who are unvaccinated or who have not been vaccinated recently are at greater risk of severe illness. […] Risk of severe illness also increases with the number, severity, and nature of comorbidities such as diabetes, heart diseases and obesity, immunosuppression, disability, and frailty.
- #29 COVID-19 (Coronavirus disease 2019) | health.vic.gov.auhttps://www.health.vic.gov.au/infectious-diseases/covid-19-coronavirus-disease-2019
COVID-19 can increase the risk of serious health problems for at least 12 months after getting sick, including a significantly increased risk of heart attacks, strokes or heart inflammation, blood clots in the lungs or elsewhere, kidney damage and severe mental health issues. […] Long COVID is a multi-organ condition that some people have after having COVID-19. Approximately 5-10% of people infected with SARS-CoV-2 continue to experience symptoms that last beyond 3 months after the initial infection or develop new symptoms weeks to months after their diagnosis. […] There are a wide range of symptoms, such as fatigue, shortness of breath, changes in smell or taste, chest pain, difficulty sleeping, anxiety or depression, headache, and cognitive dysfunction. […] A significant proportion of people experience symptoms so severe it affects their usual activities. […] SARS-CoV-2 can cause severe complications including pneumonia, acute respiratory distress syndrome (ARDS), complications affecting other organ systems, and long-term health issues.
- #30 Differences in clinical characteristics between coronavirus disease 2019 (COVID-19) and influenza: a systematic review and meta-analysis | npj Primary Care Respiratory Medicinehttps://www.nature.com/articles/s41533-025-00414-0
COVID-19 was more common among men (OR=1.46, 95% CI: 1.231.74) and people with a higher body mass index (MD=1.43, 95% CI: 1.091.77). […] Patients with COVID-19 had longer stays in the hospital (MD=3.20, 95% CI: 2.583.82) and ICU (MD=3.10, 95% CI: 1.444.76), required mechanical ventilation more frequently (OR=2.30, 95% CI: 1.773.00), and had higher mortality (OR=2.22, 95% CI: 1.932.55). […] There are some differences in the major characteristics, symptoms, laboratory findings and comorbidities between COVID-19 patients and influenza patients. COVID-19 patients often require more medical resources and have worse clinical outcomes. […] COVID-19 patients often present with influenza-like symptoms. […] Patients with COVID-19 were more likely to have diarrhea (OR=1.65, 95% CI: 1.302.08, I2=19.6%, p=0.001), while rhinorrhea (OR=0.38, 95% CI: 0.190.75, I2=78.7%, p=0.005), expectoration (OR=0.29, 95% CI: 0.220.39, I2=47.3%, p=0.001), cough (OR=0.54, 95% CI: 0.400.72, I2=78.1%, p=0.001) and sore throat (OR=0.64, 95% CI: 0.440.93, I2=73.0%, p=0.020) were more common among influenza patients.
- #30 Differences in clinical characteristics between coronavirus disease 2019 (COVID-19) and influenza: a systematic review and meta-analysis | npj Primary Care Respiratory Medicinehttps://www.nature.com/articles/s41533-025-00414-0
Our study showed that platelet counts (SMD=0.42, 95% CI: 0.280.56, I2=92.2%, p=0.001) and hemoglobin (SMD=0.24, 95% CI: 0.070.41, I2=91.5%, p=0.006) and ALT (SMD=0.35, 95% CI: 0.170.54, I2=88.6%, p=0.001) levels were higher in COVID-19 patients than in influenza patients. […] We compared 11 comorbidities between patients with COVID-19 and those with influenza and found that patients with COVID-19 were more likely to develop diabetes (OR=1.09, 95% CI: 1.01 1.17, I2=86.2%, p=0.028).
- #31 Coronavirus Disease 2019 (COVID-19) | Airborne Disease Surveillance Epidemiology Program | MeCDC | Maine DHHShttps://www.maine.gov/dhhs/mecdc/infectious-disease/epi/airborne/coronavirus.shtml
Signs and symptoms of COVID-19 are similar to influenza (flu) and include: Coughing into elbow, Headache, Shortness of breath or difficulty breathing, Sore throat, Fever or Chills, New loss of taste or smell, Fatigue, Congestion or runny nose, Muscle or body aches, Nausea or vomiting, Diarrhea. […] Symptoms may appear 2-14 days after exposure. […] Most patients experience relatively mild symptoms and can recover at home. Some patients, like those with underlying medical conditions, may experience more severe respiratory illness. […] Multisystem Inflammatory Syndrome in Children, MIS-C, is a serious but rare complication of COVID-19. It causes inflammation of certain body parts.
- #32 Multisystem Inflammatory Syndrome in Children (MIS-C) | Department of Healthhttps://coronavirus.health.ny.gov/multisystem-inflammatory-syndrome-children-mis-c
Though most children who get COVID-19 experience only mild symptoms, some children experience severe illness after an apparent recovery from COVID-19 infection. Symptoms of MIS-C may occur two or more weeks after acute COVID-19 illness. […] Should your child develop any of the following symptoms following COVID-19 illness, you should seek immediate care for your child from your childs healthcare provider: Fever, Bloodshot eyes, Skin Rash, Inflammation of oral mucosa, Stomach Pain, Diarrhea, Vomiting, Difficulty feeding (infants) or is too sick to drink fluids. […] Should your child develop any of the following severe symptoms, you should seek emergency medical care when the child has: Change in skin color – becoming pale, patchy and/or blue, Trouble breathing or is breathing very quickly, Racing heart or chest pain, Decreased amount or frequency of urine, Confusion, not acting right, or wont wake up or stay awake. […] Early recognition by pediatricians and referral to a specialist including to critical care are essential.
- #33 Long COVID (Post-COVID Conditions, PCC) > Fact Sheets > Yale Medicinehttps://www.yalemedicine.org/conditions/long-covid-post-covid-conditions-pcc
Long COVID, also known as Post-COVID Conditions (PCC), refers to the wide range of symptoms and conditions that some people experience four or more weeks after an initial infection by SARS-CoV-2, the virus that causes COVID-19. The symptoms and conditions, which may last for weeks, months, or years, can be persistent (meaning they developed during an acute COVID-19 illness and haven’t gone away), recurrent (meaning they may go away after the initial illness then return), or new (meaning they were not present initially but developed later). […] Symptoms of Long COVID can range in severity from mild to debilitating. Some people report that Long COVID symptoms prevent them from returning to work or school, and others have difficulties performing everyday chores or even walking short distances.
- #33 Long COVID (Post-COVID Conditions, PCC) > Fact Sheets > Yale Medicinehttps://www.yalemedicine.org/conditions/long-covid-post-covid-conditions-pcc
Long COVID can affect anyone, including children, and it can develop in people who had asymptomatic, mild, or severe COVID-19. Some people, however, are at increased risk, including: […] COVID-19 can affect the function of multiple organs in the body, including the lungs, heart, brain, kidneys, and liver. Because of this, Long COVID is associated with a broad range of symptoms, including respiratory, neurological, cardiac, and psychological problems, among others. […] Symptoms of Long COVID may include: Fatigue, feeling tired; Weakness; Brain fog (problems concentrating or thinking); Headaches; Tremor; Rapid or pounding heartbeat, feeling of skipped heartbeats (palpitations); Dizziness upon standing; Symptoms that worsen after physical or mental activity (known as post-exertional malaise, PEM); Gastrointestinal symptoms including stomach pain, diarrhea, and/or constipation; Loss of or change in smell and/or taste; Thirst (for instance, dry mouth); Cough; Changes in comfort or capacity for sex and/or desire for sex; Chest pain, tightness, or pressure; Hearing problems, including hearing loss or ringing in the ears (tinnitus); Shortness of breath; Muscle and/or joint pain; Back pain; Sleep apnea; Fever, sweats, and/or chills; Hair loss; Sleep problems, including insomnia; Bladder problems, including difficulty urinating or incontinence; Vision problems, such as blurry vision, sensitivity to light, floaters, flashing lights, or difficulty reading or focusing eyes; Depression; Anxiety; Swelling of the legs; Problems with teeth; Foot pain; Skin rash; Abnormal movements; Skin color changes (for instance, skin that is red, white, or purple); Changes in menstrual cycle.
- #33 Long COVID (Post-COVID Conditions, PCC) > Fact Sheets > Yale Medicinehttps://www.yalemedicine.org/conditions/long-covid-post-covid-conditions-pcc
Some people report that Long COVID symptoms prevent them from returning to work or school, and some with Long COVID have difficulties performing everyday chores or even walking short distances. […] COVID-19 can damage multiple organs throughout the body, including the brain, heart, lungs, liver, and kidneys, among others. When this happens, it can increase the risk of the development of new medical conditions, including: Diabetes; Kidney disease; Heart conditions; Neurological conditions; Blood clots; Postural orthostatic tachycardia syndrome (POTS), a condition in which the heart beats faster when standing up from a lying down position and can cause lightheadedness and fainting.
- #34 Azthena logo with the word Azthenahttps://www.news-medical.net/news/20250501/COVID-19-leaves-longer-lasting-symptoms-than-flu-or-pneumonia-study-finds.aspx
Even mild COVID-19 cases can trigger lingering symptoms, especially in women and younger adults, while severe cases show a strong link to long-term fatigue, brain fog, and joint pain, setting COVID-19 apart from other respiratory infections. […] Among symptomatic COVID-19 patients, nearly two-thirds regain their usual health status within one or two months, while others experience protracted recoveries. […] According to the United States Centers for Disease Control and Prevention, long COVID is defined as sequelae that persist for at least three months following the initial infection. However, other studies suggest post-acute COVID-19 as symptoms lasting up to 120 days after recovery. […] In the COVID-19 cohort, fatigue, dyspnea, and joint pain were the most common symptoms after four weeks.
- #34 Azthena logo with the word Azthenahttps://www.news-medical.net/news/20250501/COVID-19-leaves-longer-lasting-symptoms-than-flu-or-pneumonia-study-finds.aspx
While symptoms tended to decrease over time, they persisted across all severity levels at three and six months, although the increased odds of having symptoms remained highest for the most severe initial cases (levels 7 and 8) compared to the least severe (level 3). […] The findings corroborate prior observations that fatigue, dyspnea, and joint pain are the most common persistent symptoms after acute COVID-19. […] Symptoms observed four weeks after initial COVID-19 were likely to improve later. However, appreciable levels of symptoms lingered that correlated with the severity of the initial COVID-19 episode. […] Overall, COVID-19 symptomatology cannot be perfectly described by pneumonia or influenza symptomatology, and there are differences in symptom prevalence and the time to resolution that better characterize long COVID, indicating that this persistence is unique to COVID-19.
- #35 Minimizing COVID-19 Symptoms: Prevention and Treatment Optionshttps://www.lvhn.org/conditions/covid-19-infection
However, some people at high risk for developing or who are experiencing severe symptoms may need specialized care and treatment, including antiviral medications, steroids/anti-inflammatory drugs, remote monitoring or hospitalization. […] Some people who develop COVID-19 go on to experience long-term symptoms and conditions related to their initial illness. Known as post-acute sequelae of COVID (PASC), or Long COVID, these ongoing health problems can last for weeks, months or years and include: Anxiety/depression, Blood clots, Changes in smell or taste, Changes in your menstrual cycle, Chest pain, Cough, Diarrhea, Difficulty thinking or concentrating, Dizziness, Fatigue that interferes with daily life, Headaches, Heart palpitations, Muscle and/or joint pain, Rashes, Recurrent fevers, Shortness of breath/difficulty breathing, Sleep problems, Stomach pain, Tingling, burning or numbness of the skin. […] If you are experiencing ongoing health concerns after facing COVID-19, be sure to speak with your family doctor for additional evaluation and care.
- #35 Minimizing COVID-19 Symptoms: Prevention and Treatment Optionshttps://www.lvhn.org/conditions/covid-19-infection
While most individuals will only experience mild symptoms of COVID-19, some will develop severe symptoms, including: Change in mental status (such as confusion), Extreme sleepiness, trouble waking up or difficulty staying awake, Pale, gray or blue-colored skin, lips or nail beds, Persistent chest pain or pressure, Persistent or worsening cough, Persistent or worsening difficulty breathing, Persistent or worsening fever, Shortness of breath while resting. […] If you are experiencing any of the urgent symptoms above, call 911 or go to your closest emergency room. […] If you have any of these risk factors and experience symptoms of COVID-19, itâs important to get tested as soon as possible and let your family doctor know if you are positive. […] Most people with COVID-19 can recover at home and take over-the-counter medications, increase their fluid intake and get more rest to improve their mild symptoms.
- #36 Coronavirus Resource Center – Harvard Healthhttps://www.health.harvard.edu/diseases-and-conditions/coronavirus-resource-center
COVID-19 (coronavirus disease 2019) is a respiratory illness caused by the SARS-CoV-2 virus. It is very contagious, and spreads quickly. […] Most people with COVID-19 have mild respiratory symptoms that feel much like a cold or flu. But it can be much more serious for older adults, people with underlying medical conditions, and those who haven’t been vaccinated against COVID-19. Some people may go on to suffer from post-COVID conditions, known as long COVID. […] Long COVID: the constellation of symptoms experienced by COVID long-haulers. These symptoms may include brain fog, shortness of breath, chills, body ache, headache, joint pain, chest pain, cough, and lingering loss of taste or smell. […] Long-haulers: people who have not fully recovered from COVID-19 weeks or even months after first experiencing symptoms.
- #37https://link.springer.com/article/10.1007/s00431-024-05919-3
Lack of a control group(s) and selection bias were the main criticisms of previous studies investigating the prevalence of post-coronavirus disease 2019 (COVID-19) syndrome (PCS). […] The number of children with1 PCS symptom(s) was comparable between the COVID-19 (n=114 [62.1%]) and control (n=66 [64.9%]) groups. Concentration disorders were reported more frequently in the COVID-19 group (12.3% versus 1.5%; p=0.012) and physical performance was significantly impaired (p=0.016) regardless of age, sex, and SARS-CoV-2 vaccination. […] Children with and without previous infections did not differ in most PCS-associated symptoms. Exceptions included physical performance and cognitive problems, which appeared to be more impaired after Omicron infection than in controls. […] According to the WHO, the most frequently reported symptoms of PCS include fatigue, altered smell/anosmia, and anxiety. In addition, many other sometimes nonspecific symptoms may occur in different organ systems, including chest pain, cognitive difficulties, dyspnoea, headache, abdominal pain, and sore eyes and throat.
- #37https://link.springer.com/article/10.1007/s00431-024-05919-3
The analysis of the score physical performance (i.e. derived from the parameters dyspnoea during exertion, limited physical capacity, circulatory problems during exertion, and assessment of own fitness) revealed a significant impaired physical performance (OR 3.08 [95% CI 1.337.15]; p=0.016) in the COVID-19 group. […] Despite the increase in SARS-CoV-2 infections during the Omicron wave, the number of children with1 typical PCS symptom(s) was similar in both groups, as was the frequency of the symptoms reported individually. However, impaired concentration and reduced physical performance were significantly more common among children with Omicron infection. […] Compared with the initial years of the pandemic, the incidence of PCS decreased significantly in the Omicron era. However, following infection with the Omicron variant, PCS-associated symptoms, such as fatigue and dermatological, gastrointestinal, sleep, and sensory manifestations, have also been described in children and adolescents. […] Children in the COVID-19 group rated their fitness as worse, with otherwise equal ratings of QoL regarding general and mental health.
- #38 COVID-19 | Communicable Diseases Agencyhttps://www.moh.gov.sg/covid-19
The signs and symptoms of a COVID-19 infection range from mild respiratory symptoms to severe illnesses such as pneumonia. […] Common symptoms of COVID-19 include: Fever, Chills, Sore throat, Cough, Nasal congestion, runny nose, Headache, Loss of taste or smell, Fatigue, Muscle aches, Nausea, Diarrhoea. […] In severe cases, COVID-19 can manifest as pneumonia with shortness of breath and chest pain. […] Some may experience long-term effects from COVID-19 infection known as Long COVID or Post-Acute Sequelae of COVID-19 (PASC). „Long COVID” or PASC is a general reference to new or persistent symptoms experienced by some persons 4 weeks or more after a COVID-19 infection with no alternate diagnosis. […] Such persistent symptoms are more commonly seen after severe COVID-19 and among unvaccinated persons. Most symptoms, such as cough and fatigue, resolve on their own over time. However, persons with more severe symptoms, such as shortness of breath or chest pain, may require further medical assessment and care, and are advised to seek medical attention.
- #39 Coronavirus Disease 2019 (COVID-19) in Children | Children’s Hospital of Philadelphiahttps://www.chop.edu/conditions-diseases/coronavirus-disease-2019-covid-19-in-children
Please refer to this helpful information about COVID-19 symptoms and what to do if your child is exposed to COVID-19. […] Symptoms can range from mild to severe respiratory illness. […] Symptoms concerning for COVID-19 in children include: Cough, Shortness of breath, Difficulty breathing, Loss of taste or smell. […] Additional non-specific symptoms may be due to COVID-19, but may also be due to another infection. These symptoms include: Fever, Sore throat, Runny nose, Headache or body aches, Chills, Fatigue, Gastrointestinal symptoms such as vomiting or diarrhea. […] It is important to review your child’s symptoms with their doctor to determine if they should be tested for COVID-19. Vaccinated children have milder symptoms than unvaccinated children. […] In many cases, this virus can cause infection (pneumonia) in both lungs. […] Rarely, some children have developed severe complications called multisystem inflammatory syndrome in children (MIS-C).
- #40 Coronavirus Disease (COVID-19) | March of Dimeshttps://www.marchofdimes.org/find-support/topics/pregnancy/coronavirus-disease-covid-19
The symptoms of COVID-19 may be similar to symptoms of the flu, including these possible symptoms listed on the CDC website. Symptoms can be mild or severe. They can appear 2 to 14 days after exposure to the virus. Some people with COVID-19 have no symptoms. […] Pregnancy causes changes in the body that could make it easier to get very sick from respiratory viruses like the one that causes COVID-19. Pregnant people and those who were recently pregnant face increased risks if they get COVID-19. These risks include: Higher risk of severe illness or death from COVID-19, More likely to be admitted to the hospital or the intensive care unit (ICU), More likely to need a ventilator or special equipment to help them breathe, Higher risk of preterm birth and stillbirth, There may be a higher risk of other pregnancy complications, such as preeclampsia/eclampsia, blood clots, bleeding problems after birth, heart problems and cesarean (C-section) birth.
- #40 Coronavirus Disease (COVID-19) | March of Dimeshttps://www.marchofdimes.org/find-support/topics/pregnancy/coronavirus-disease-covid-19
Data shows that symptoms of COVID-19 may be less severe in babies and children than in adults, but some babies and children can get very sick from COVID-19. Babies younger than one year of age are at a higher risk for severe illness from COVID-19 than older children. […] If you have a fever, cough or other flu-like symptoms, you may have COVID-19. Call your health care provider and ask what you should do. Your provider may recommend certain treatments, especially if you’re at high risk for serious illness. […] If you have COVID-19 and are at high risk for severe illness or hospitalization, your provider may recommend certain treatments to help reduce these risks. These medicines are most effective when started within a few days after symptoms begin. These prescription medicines can help reduce the spread of the COVID-19 virus in the body.
- #41 COVID-19 symptoms appear in a specific order, study finds – Big Thinkhttps://bigthink.com/health/covid-symptoms-sequence/
COVID-19 symptoms appear in a specific order, study finds. One reason to suspect you have COVID-19 may be the order in which the symptoms appear. USC researchers identify a distinct order in which COVID-19 symptoms present themselves. If you experience these symptoms in this order, call your doctor. According to their investigation, it’s likely that coronavirus symptoms present in a particular order. This is unusual; other illnesses that produce these symptoms don’t follow any known sequence and if a person gets these symptoms in this particular order, they should self-isolate and get tested. The USC team says that coronavirus symptoms present in this order: fever, cough and muscle pain, nausea and/or vomiting, diarrhea. What really sets apart COVID-19 from other diseases is the timing of the nausea/vomiting and diarrhea. COVID-19 attacks the upper GI tract first, causing nausea/vomiting before moving down to the lower GI tract, producing diarrhea. This order is especially important to know when we have overlapping cycles of illnesses like the flu that coincide with infections of COVID-19. The order of the symptoms matter. Knowing that each illness progresses differently means that doctors can identify sooner whether someone likely has COVID-19, or another illness, which can help them make better treatment decisions.
- #42 Updates | Programs and initiatives | City of Philadelphiahttps://www.phila.gov/programs/coronavirus-disease-2019-covid-19/updates/
If you are sick, you should stay home. […] Follow the latest CDC guidance for what to do if you have symptoms of a respiratory virus (COVID-19, flu, or Respiratory Syncytial Virus (RSV) or have tested positive for a respiratory virus. […] If you are sick, you should stay home. You can return to normal activities when, for at least 24 hours: […] Your symptoms are getting better overall AND […] You are fever-free without fever-reducing medicine. […] When you go back to your normal activities, take added precautions over the next 5 days, such as taking additional steps for cleaner air, hygiene, masks, physical distancing, and/or testing when you will be around other people indoors. […] If you are exposed to someone with a respiratory virus, monitor your symptoms and take added precautions for 1-2 weeks (see above). In case you did get the virus, this will help reduce the risk of getting anyone else sick.
- #43 About COVID-19 – MN Dept. of Healthhttps://www.health.state.mn.us/diseases/coronavirus/basics.html
COVID-19 affects a persons nose and throat and can sometimes affect a persons lungs and can make it hard to breathe normally. […] Symptoms of COVID-19 can include fever, cough, shortness of breath, chills, headache, muscle pain, congestion or runny nose, sore throat, fatigue, or loss of taste or smell. Other less common symptoms include stomach symptoms like nausea, vomiting, or diarrhea. […] These symptoms may show up 2-14 days after you are around someone who has COVID-19. […] Not everyone with COVID-19 has all of these symptoms, and some people may not have any symptoms. […] Even after recovering from COVID-19, some people may have symptoms that continue for a long time such as fatigue, cough, or joint pain. […] The virus that causes COVID-19 can affect people in different ways. Some can get very sick, while most have mild or moderate symptoms and get better without going to a clinic or into a hospital. Some have no symptoms. Some people die.
- #44 CoxHealth | COVID-â19https://www.coxhealth.com/condition/coronavirus-disease-2019-covid-19/
COVID-19 is an infectious disease that most often causes a respiratory illness. Symptoms can range from mild to severe respiratory illness. Symptoms can vary a lot from person to person. Some people have no symptoms (this is called asymptomatic). Some people have mild symptoms, and some people report feeling very sick. Symptoms may appear 2 to 14 days after contact with the virus. Symptoms can include: […] Symptoms include fever, coughing, and trouble breathing. Some people report digestive upset, loss of appetite, runny nose, headache and body aches, chills or repeated shaking with chills, and new loss of taste and smell. In some cases, this virus can cause lung infection (pneumonia). […] If you have COVID-19 and are more likely to get very sick, contact your health care provider or seek care right away. There are treatments available to reduce your risk of getting very sick or being hospitalized. Don’t delay contacting your provider or seeking care. Treatment must be started within 5 to 7 days after you first develop symptoms.